Mmp9

Summary

Gene Symbol: Mmp9
Description: matrix metallopeptidase 9
Alias: matrix metalloproteinase-9, 92 kDa gelatinase, 92-kDa type IV collagenase, GELB, MMP-9, gelatinase B, matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)
Species: rat

Top Publications

  1. ncbi S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death
    Zezong Gu
    Center for Neuroscience and Aging, Program in Cell Adhesion and Extracellular Matrix Biology, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 297:1186-90. 2002
  2. pmc Pancreatic trypsin increases matrix metalloproteinase-9 accumulation and activation during acute intestinal ischemia-reperfusion in the rat
    Henrique S Rosario
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, California 92093, USA
    Am J Pathol 164:1707-16. 2004
  3. ncbi Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice
    Mengzhou Xue
    Hotchkiss Brain Institute and Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Neurosci 26:10281-91. 2006
  4. ncbi The association of single nucleotide polymorphisms in the MMP-9 genes with susceptibility to acute primary angle closure glaucoma in Taiwanese patients
    I Jong Wang
    Department of Ophthalmology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Vis 12:1223-32. 2006
  5. doi Association of a nonsynonymous single-nucleotide polymorphism of matrix metalloproteinase 9 with giant cell arteritis
    A Rodriguez-Pla
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 58:1849-53. 2008
  6. pmc Genetic variations and plasma levels of gelatinase A (matrix metalloproteinase-2) and gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy
    Michal Beranek
    Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Mol Vis 14:1114-21. 2008
  7. doi Prevention of ischemia/reperfusion-induced accumulation of matrix metalloproteinases in rat lung by preconditioning with nitric oxide
    Thomas Waldow
    Clinic for Cardiac Surgery, University Hospital Dresden, Dresden, Germany
    J Surg Res 152:198-208. 2009
  8. pmc Matrix metalloproteinases with gelatinolytic activity induced by Paracoccidioides brasiliensis infection
    Angela Satie Nishikaku
    Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, SP, Brazil
    Int J Exp Pathol 90:527-37. 2009
  9. doi Matrix metalloproteinase-9 activity increased by two different types of epileptic seizures that do not induce neuronal death: a possible role in homeostatic synaptic plasticity
    Eszter Takács
    Laboratory of Proteomics, Institute of Biology, Eotvos Lorand University, Budapest, Hungary
    Neurochem Int 56:799-809. 2010
  10. pmc Calmodulin kinase II-dependent transactivation of PDGF receptors mediates astrocytic MMP-9 expression and cell motility induced by lipoteichoic acid
    Hui Hsin Wang
    Department of Physiology and Pharmacology, Chang Gung University, Tao Yuan, Taiwan
    J Neuroinflammation 7:84. 2010

Detail Information

Publications153 found, 100 shown here

  1. ncbi S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death
    Zezong Gu
    Center for Neuroscience and Aging, Program in Cell Adhesion and Extracellular Matrix Biology, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 297:1186-90. 2002
    ..These findings suggest a potential extracellular proteolysis pathway to neuronal cell death in which S-nitrosylation activates MMPs, and further oxidation results in a stable posttranslational modification with pathological activity...
  2. pmc Pancreatic trypsin increases matrix metalloproteinase-9 accumulation and activation during acute intestinal ischemia-reperfusion in the rat
    Henrique S Rosario
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, California 92093, USA
    Am J Pathol 164:1707-16. 2004
    ..This process represents a powerful in vivo pathophysiological mechanism for trypsin-induced MMP-9 activation and is likely to play a central role in the development of acute intestinal inflammation and shock...
  3. ncbi Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice
    Mengzhou Xue
    Hotchkiss Brain Institute and Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Neurosci 26:10281-91. 2006
    ..To improve the prognosis of ICH, the neurotoxic actions of thrombin and MMP-9 must be inhibited early and simultaneously after injury...
  4. ncbi The association of single nucleotide polymorphisms in the MMP-9 genes with susceptibility to acute primary angle closure glaucoma in Taiwanese patients
    I Jong Wang
    Department of Ophthalmology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Vis 12:1223-32. 2006
    ....
  5. doi Association of a nonsynonymous single-nucleotide polymorphism of matrix metalloproteinase 9 with giant cell arteritis
    A Rodriguez-Pla
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 58:1849-53. 2008
    Giant cell arteritis (GCA) is the most common type of primary vasculitis. Matrix metalloproteinase 9 (MMP-9) is present in arterial lesions of GCA and may be involved in its pathogenesis...
  6. pmc Genetic variations and plasma levels of gelatinase A (matrix metalloproteinase-2) and gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy
    Michal Beranek
    Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Mol Vis 14:1114-21. 2008
    ....
  7. doi Prevention of ischemia/reperfusion-induced accumulation of matrix metalloproteinases in rat lung by preconditioning with nitric oxide
    Thomas Waldow
    Clinic for Cardiac Surgery, University Hospital Dresden, Dresden, Germany
    J Surg Res 152:198-208. 2009
    ..The aim of this study was to evaluate the effects of NO preconditioning on I/R-induced changes of matrix metalloproteinase (MMP) activity...
  8. pmc Matrix metalloproteinases with gelatinolytic activity induced by Paracoccidioides brasiliensis infection
    Angela Satie Nishikaku
    Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, SP, Brazil
    Int J Exp Pathol 90:527-37. 2009
    ..Our findings demonstrate the induction of MMPs, particularly MMP-9, in experimental paracoccidioidomycosis, suggesting a possible influence in the pattern of granulomas and in fungal dissemination...
  9. doi Matrix metalloproteinase-9 activity increased by two different types of epileptic seizures that do not induce neuronal death: a possible role in homeostatic synaptic plasticity
    Eszter Takács
    Laboratory of Proteomics, Institute of Biology, Eotvos Lorand University, Budapest, Hungary
    Neurochem Int 56:799-809. 2010
    ..In these epilepsy models MMP-9 induction may therefore be associated with functions such as homeostatic synaptic plasticity rather than neuronal death...
  10. pmc Calmodulin kinase II-dependent transactivation of PDGF receptors mediates astrocytic MMP-9 expression and cell motility induced by lipoteichoic acid
    Hui Hsin Wang
    Department of Physiology and Pharmacology, Chang Gung University, Tao Yuan, Taiwan
    J Neuroinflammation 7:84. 2010
    ..However, the molecular mechanisms underlying LTA-induced MMP-9 expression in brain astrocytes remain unclear...
  11. pmc Transforming growth factor-β1 induces matrix metalloproteinase-9 and cell migration in astrocytes: roles of ROS-dependent ERK- and JNK-NF-κB pathways
    Hsi Lung Hsieh
    Department of Nursing, Division of Basic Medical Sciences, Chang Gung Institute of Technology, Tao Yuan, Taiwan
    J Neuroinflammation 7:88. 2010
    ..Both TGF-β and MMPs have been shown to play crucial roles in brain pathological changes. Thus, we investigated the molecular mechanisms underlying TGF-β1-induced MMP-9 expression in brain astrocytes...
  12. pmc Matrix metalloproteinase-9 genetic variation and primary angle closure glaucoma in a Caucasian population
    Mona S Awadalla
    Ophthalmology Department, Flinders University, Adelaide, South Australia, Australia
    Mol Vis 17:1420-4. 2011
    To investigate the association between genetic variation at the matrix metalloproteinase-9 (MMP9) locus and primary angle closure glaucoma (PACG) in an Australian Caucasian population.
  13. ncbi ProMMP-9 (92 kDa gelatinase) in vitreous fluid of patients with proliferative diabetic retinopathy
    H Kosano
    Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan
    Life Sci 64:2307-15. 1999
    ..16-7.61), declining in patients with 'quiescent' PDR (1.04 ng/ml, 0.16-3.77). These results suggest that MMP-9 is one of the noteworthy factors in relation to the progress of PDR, as well as angiogenic cytokines such as VEGF...
  14. ncbi Matrix metalloproteinase-9 undergoes expression and activation during dendritic remodeling in adult hippocampus
    Arek Szklarczyk
    Laboratory of Molecular Neurobiology, Nencki Institute, PL 02 093 Warsaw, Poland
    J Neurosci 22:920-30. 2002
    ..This unique spatiotemporal pattern of MMP-9 expression suggests its involvement in activity-dependent remodeling of dendritic architecture with possible effects on synaptic physiology...
  15. ncbi Gelatinase B and TIMP-1 are regulated in a cell- and time-dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia
    Santiago Rivera
    IFR Jean Roche, Faculte de Medecine Nord, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
    Eur J Neurosci 15:19-32. 2002
    ..vulnerable and resistant areas of the ischemic rat hippocampus, the kinetics and cellular distribution of gelatinase B and its principal inhibitor TIMP-1 and we assessed by in situ zymography, the net gelatinolytic activity at the ..
  16. pmc Matrix metalloproteinase-9 contributes to choroidal neovascularization
    Vincent Lambert
    Laboratory of Tumor and Development Biology, University of Liege, Liege, Belgium
    Am J Pathol 161:1247-53. 2002
    ..We report here that MMP-9 (gelatinase B) expression is induced and temporally regulated in the course of experimental choroidal neovascularization...
  17. ncbi Induction of matrix metalloproteinase-9 (MMP-9) in lipopolysaccharide-stimulated primary astrocytes is mediated by extracellular signal-regulated protein kinase 1/2 (Erk1/2)
    Woo Jong Lee
    Department of Pharmacology, College of Pharmacy, Seoul National University, Korea
    Glia 41:15-24. 2003
    ..The Erk1/2-mediated MMP-9 induction may provide insights into the regulation of MMP-9 production in CNS, which may occur in vivo in pathological situations such as CNS inflammation...
  18. ncbi Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1
    Hsi Lung Hsieh
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Cell Signal 16:1163-76. 2004
    ..This study may provide insights into the regulation of MMP-9 production in CNS, which may occur in vivo in pathological situations such as CNS inflammation and brain astrocytoma...
  19. ncbi High serum levels of matrix metalloproteinase-9 and matrix metalloproteinase-1 are associated with rapid progression in patients with metastatic melanoma
    Johanna Nikkola
    Department of Oncology and Radiotherapy, Turku University Hospital, Finland
    Clin Cancer Res 11:5158-66. 2005
    ..In the present work, we have studied the prognostic significance of serum levels of gelatinase B (MMP-9), collagenase-1 (MMP-1), and collagenase-3 (MMP-13) in patients with advanced melanoma.
  20. pmc Matrix metalloproteinase gelatinase B (MMP-9) is associated with leaking glaucoma filtering blebs
    Shravan K Chintala
    Eye Research Institute, Oakland University, 40g Dodge Hall, Rochester, MI, USA
    Exp Eye Res 81:429-36. 2005
    ..of a high molecular weight caseinase and a 92-kDa gelatinase of a size appropriate for the proenzyme form of gelatinase B (gelB; MMP-9), in extracts from leaking bleb tissue, but not in bleb leak fluid or aqueous humour samples...
  21. pmc Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory
    Vanja Nagy
    Fishberg Department of Neuroscience, The Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosci 26:1923-34. 2006
    ..Together, these data reveal new functions for MMPs in synaptic and behavioral plasticity...
  22. ncbi Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke
    Anna Rosell
    Department of Neurology, Vall d Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    Stroke 37:1399-406. 2006
    ..We aimed to investigate MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in brain parenchyma in both ischemic and hemorrhagic strokes.
  23. ncbi Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation
    Anna Pryczynicz
    Department of General Pathomorphology, Medical University of Białystok, Białystok, Poland
    Folia Histochem Cytobiol 45:37-40. 2007
    The objective of the current study was to assess the expression of matrix metalloproteinase 9 (MMP-9) in pancreatic ductal carcinoma and to examine its correlation with chosen clinico-anatomical parameters...
  24. pmc In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity
    Ozlem Bozdagi
    Fishberg Dept of Neuroscience, The Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Neurophysiol 98:334-44. 2007
    ..Taken together, our data reveal novel roles for MMP-mediated proteolysis in regulating nonpathological synaptic function and plasticity in mature hippocampus...
  25. ncbi Gelatinolytic activities (matrix metalloproteinase-2 and -9) and soluble extracellular domain of Her-2/neu in pleural effusions
    Angelina Di Carlo
    Dipartimento di Medicina Sperimentale, Universita di Roma La Sapienza, I 00161 Roma, Italy
    Oncol Rep 18:425-31. 2007
    ..The levels of HER-2/neu ECD were above the cut-off value in breast cancer patients. No correlation between gelatinolytic activities and high HER-2/neu ECD values was found...
  26. ncbi Matrix metalloproteinase-9 is involved in the development and plasticity of retinotectal projections in rats
    Priscilla Oliveira-Silva
    Neuroimmunology Program, Fluminense Federal University, Niteroi, Brazil
    Neuroimmunomodulation 14:144-9. 2007
    ..We studied the expression and role of MMPs during normal development of retinotectal projections and after monocular enucleation-induced plasticity...
  27. doi Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes
    Min Sik Choi
    Department of Pharmacology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea
    Brain Res Bull 76:368-75. 2008
    ..MMP-9 promoter reporter assay confirmed the positive effect of ERK1/2 on MMP-9 expression. These results suggest that the activation of PAR1 mediates thrombin-induced MMP-9 expression through the regulation of Erk1/2...
  28. pmc Early and late changes of MMP-2 and MMP-9 in bleomycin-induced pulmonary fibrosis
    Ji Young Kim
    Department of Pathology, Pochon CHA University, College of Medicine, Gyeonggi Do, Korea
    Yonsei Med J 50:68-77. 2009
    ....
  29. pmc Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat
    Aida Maddahi
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    BMC Neurosci 10:56. 2009
    ..The formation of oedema and opening of the blood-brain barrier in stroke is associated with enhanced expression of metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1)...
  30. pmc MMP-9 gene variants increase the risk for non-atopic asthma in children
    Leonardo A Pinto
    Department of Pediatric Pneumology and Neonatology, Hannover Medical School, Hannover, Germany
    Respir Res 11:23. 2010
    ..Both neutrophils as well as eosinophils may secrete matrix metalloproteinase 9 (MMP-9)...
  31. doi The role of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury
    Tetsuhiro Higashida
    Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosurg 114:92-101. 2011
    ....
  32. pmc Japanese encephalitis virus induces matrix metalloproteinase-9 in rat brain astrocytes via NF-κB signalling dependent on MAPKs and reactive oxygen species
    Wei Hsuan Tung
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    Br J Pharmacol 161:1566-83. 2010
    ..However, the detailed mechanisms underlying the inflammatory action of JEV are largely unclear...
  33. pmc Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucomas
    Georg Mossbock
    Department of Ophthalmology, Medical University of Graz, Graz, Austria
    Mol Vis 16:1764-70. 2010
    ..MMP1, MMP2, and MMP9 have previously been implicated in the pathogenesis of primary open angle glaucoma (POAG) and open angle glaucoma ..
  34. doi Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology
    Piotr Michaluk
    Department of Molecular and Cellular Neurobiology, The Nencki Institute, Pasteura 3, 02 093 Warsaw, Poland
    J Cell Sci 124:3369-80. 2011
    ..Our results, considered together with several recent studies, strongly imply that MMP-9 is functionally involved in synaptic remodelling...
  35. pmc Abrogation of MMP-9 gene protects against the development of retinopathy in diabetic mice by preventing mitochondrial damage
    Renu A Kowluru
    Kresge Eye Institute, Wayne State University, Detroit, Michigan, USA
    Diabetes 60:3023-33. 2011
    ..The objective of this study is to elucidate the plausible mechanism by which active MMP-9 contributes to the mitochondrial dysfunction in the retina...
  36. doi Cytokine concentration in aqueous humour of eyes with exudative age-related macular degeneration
    Jost B Jonas
    Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University Heidelberg, Germany
    Acta Ophthalmol 90:e381-8. 2012
    ..To measure the concentration of cytokines in the aqueous humour of eyes with exudative age-related macular degeneration (AMD)...
  37. pmc Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction
    Hiroshi Kamada
    Department of Neurosurgery, Stanford University, Stanford, CA 94305 5487, USA
    Stroke 38:1044-9. 2007
    ..Our present study was designed to clarify the relation among hyperglycemia, oxidative stress, and MMP-9 activation associated with BBB dysfunction after transient focal cerebral ischemia (tFCI)...
  38. ncbi Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis
    B C Kieseier
    Department of Neurology, Julius Maximilians Universitat, Wurzburg, Germany
    Brain 121:159-66. 1998
    ..Our findings indicate that 92-kDa gelatinase and matrilysin are selectively upregulated during AT-EAE and thus may contribute to the pathogenesis of inflammatory diseases of the CNS...
  39. ncbi Increased MMP-9 expression and activity by aortic smooth muscle cells after nitric oxide synthase inhibition is associated with increased nuclear factor-kappaB and activator protein-1 activity
    Brian S Knipp
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, Ann Arbor, Michigan 48109 0329, USA
    J Surg Res 116:70-80. 2004
    To determine the mechanism underlying increased expression and activity of matrix metalloproteinase 9 (MMP-9) by rat aortic smooth muscle cells (RA-SMC) after inhibition of inducible nitric oxide synthase (iNOS).
  40. ncbi Increased presence of matrix metalloproteinases 2 and 9 in short- and long-term experimental herpes simplex virus encephalitis
    Francisco J Martinez-Torres
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Neurosci Lett 368:274-8. 2004
    ..This study describes the protein and mRNA expression of MMP2 and MMP9 in experimental HSVE in the short and long term...
  41. ncbi Matrix metalloproteinases and tissue inhibitors of metalloproteinases in coxsackievirus-induced myocarditis
    Caroline Cheung
    Department of Pathology and Laboratory Medicine, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital Providence Health Care, University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
    Cardiovasc Pathol 15:63-74. 2006
    ..Matrix metalloproteinases (MMPs) are regulators of the ECM and can degrade all the components in the matrix...
  42. pmc Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction
    Sandro Goruppi
    Molecular Cardiology Research Institute, Tufts New England Medical Center, 750 Washington Street, Box 8486, Boston, MA 02111, USA
    Mol Cell Biol 27:993-1006. 2007
    ..containing c-Jun and with the cardiomyocyte atrial natriuretic factor (anf) promoter and the cardiac fibroblast mmp9 and mmp13 promoters, established activator protein 1 effectors...
  43. ncbi Plasma levels of matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) in age-related macular degeneration
    K Y Chau
    Institute of Ophthalmology, University College, London, UK
    Eye (Lond) 21:1511-5. 2007
    ..The aim of this study was to determine the role of systemic matrix metalloproteinases (MMPs) in AMD, given that MMPs are implicated in the pathogenesis of atherosclerosis...
  44. pmc Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanoma
    Javier Cotignola
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BMC Med Genet 8:10. 2007
    ..Some polymorphisms are known to influence gene expression, protein activity, stability, and interactions, and they were shown to be associated with certain tumor phenotypes and cancer risk...
  45. ncbi Endothelin and gelatinases in renal changes following blockade of nitric oxide synthase in hypertensive rats
    Yi Ling Yang
    Institute of Biotechnology, National Chia Yi University, Chiayi Republic of China
    Chin J Physiol 51:186-95. 2008
    ..L-NAME administration for 5 to 10 days resulted in decreases in MMP2 and MMP9 with increasing TIMP2...
  46. doi Matrix metalloproteinase-9 deficiency worsens lung injury in a model of bronchopulmonary dysplasia
    Heikki Lukkarinen
    Department of Pediatrics, University of Gothenburg, Medicinaregatan 1G, Gothenburg, Sweden
    Am J Respir Cell Mol Biol 41:59-68. 2009
    ..These results suggest that MMP-9 activity in the inflamed neonatal lung protects the lung against injury...
  47. doi Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model
    Liang Geng
    Department of Cardiology, Rui Jin Hospital, Jiao Tong University School of Medicine, Shanghai 200025, People s Republic of China
    Exp Mol Pathol 89:72-81. 2010
    ....
  48. doi Microscopical evaluation of extracellular matrix and its relation to the palatopharyngeal muscle in obstructive sleep apnea
    Fernando D Molina
    Department of Otorhinolaryngology and Service for Head and Neck Surgery, School of Medicine at Sao Jose do Rio Preto FAMERP, Sao Jose do Rio Preto, Sao Paulo, Brazil
    Microsc Res Tech 74:430-9. 2011
    ..Moreover, extracellular matrix components changes may contribute to muscle myopathy during SAHS progression...
  49. pmc Acute venous occlusion enhances matrix metalloprotease activity: Implications on endothelial dysfunction
    Tom Alsaigh
    Department of Bioengineering, The Institute for Engineering in Medicine, University of California San Diego, La Jolla, CA 92093 0412, USA
    Microvasc Res 81:108-16. 2011
    ..We conclude that venous pressure elevation increases enzymatic activity which may contribute to inflammation and endothelial dysfunction associated with this disease by influencing critical surface receptors...
  50. ncbi [The effect of prolactin on the expression of matrix metalloproteinase-9 in the synovium of adjuvant arthritis rats]
    Yong Feng Gong
    Department of Physiology, Binzhou Medical College, Binzhou 256603, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 24:95-8. 2008
    ....
  51. ncbi [Effects of dexamethasone pretreatment on expression of matrix metalloproteinase-9 in rats with acute lung injury induced by phosgene]
    Dai kun He
    Emergency and Intensive Care Centre for Chemical Accident of Jinshan Hospital Affiliated to Fudan University, Shanghai 200540, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 29:289-93. 2011
    ..To investigate the effects of dexamethasone on expression of matrix metalloproteinase-9 (MMP-9) in rats with acute lung injury induced by phosgene...
  52. doi Interaction between sympathetic nervous system and renin angiotensin system on MMPs expression in juvenile rat aorta
    Houcine Dab
    Université de Carthage, Tunisia
    Gen Physiol Biophys 30:271-7. 2011
    ..Combined inhibition of SNS and ANG II were more efficient than a single inhibition in reducing MMP amounts in rat vessels...
  53. ncbi Potential contribution of matrix metalloproteinase-9 (mmp-9) to cerebral vasospasm after experimental subarachnoid hemorrhage in rats
    Zhong Wang
    Suzhou, P R China
    Ann Clin Lab Sci 42:14-20. 2012
    This study investigated the possible involvement of matrix metalloproteinase 9 (MMP-9) in cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) in rats...
  54. doi Electroacupuncture improves behavioral recovery and increases SCF/c-kit expression in a rat model of focal cerebral ischemia/reperfusion
    Taoli Lu
    Chongqing Key Laboratory of Neurology, Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, 400016 Chongqing, China
    Neurol Sci 34:487-95. 2013
    ..EA may promote neurobehavioral recovery by increasing the protein and mRNA expression of SCF, c-kit and MMP-9 after cerebral ischemia/reperfusion...
  55. pmc Brain-derived neurotrophic factor induces matrix metalloproteinase 9 expression in neurons via the serum response factor/c-Fos pathway
    Bozena Kuzniewska
    Department of Molecular and Cellular Neurobiology, Polish Academy of Sciences, Warsaw, Poland
    Mol Cell Biol 33:2149-62. 2013
    ..study, we provide evidence that stimulation of rat primary cortical neurons with BDNF upregulates matrix metalloproteinase 9 (MMP-9) mRNA and protein levels and increases enzymatic activity...
  56. doi The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model
    Z Cavdar
    Department of Molecular Medicine, Health Sciences Institute
    Biotech Histochem 89:304-14. 2014
    ..TIMP-1 and TIMP-2 levels were increased significantly by LA administration. LA modulated increased MMP-2 and MMP-9 activities and decreased TIMP-1 and TIMP-2 levels during renal I-R...
  57. doi Curcumin attenuates liver warm ischemia and reperfusion-induced combined restrictive and obstructive lung disease by reducing matrix metalloprotease 9 activity
    N C Wu
    Division of Cardiovascular Surgery, Department of Surgery, Chi Mei Foundation Hospital, Tainan, Taiwan
    Transplant Proc 46:1135-8. 2014
    ..In this study, we aimed to investigate the protective efficacy of curcumin treatment against hepatic I/R-induced lung function impairment...
  58. ncbi Increased plasma metalloproteinase-9 concentrations precede development of microalbuminuria in non-insulin-dependent diabetes mellitus
    I Ebihara
    Department of Medicine, Koto Hospital, Tokyo, Japan
    Am J Kidney Dis 32:544-50. 1998
    ..01). However, serum MMP-1 and tissue inhibitor of MMP-1 showed no change during the study period. These data suggest that plasma MMP-9 concentrations preceded and may predict the development of microalbuminuria in NIDDM...
  59. ncbi Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure
    J T Peterson
    Departments of Cardiovascular Pharmacology, Pfizer Global Research and Development, Ann Arbor, Michigan, USA
    Circulation 103:2303-9. 2001
    ..The present study tested the hypothesis that MMP inhibition would influence LV remodeling and function in developing LV failure...
  60. pmc Functional polymorphisms in matrix metalloproteinases-1, -3, -9 are associated with arteriovenous fistula patency in hemodialysis patients
    Chih Ching Lin
    School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    Clin J Am Soc Nephrol 5:1805-14. 2010
    ..This study evaluated the association of genotype polymorphisms of MMPs and tissue inhibitors of metalloproteinases (TIMPs) in hemodialysis (HD) patients with arteriovenous fistula (AVF) failure...
  61. doi Physiological regulation of MMPs and tPA/PAI in the arterial wall of rats by noradrenergic tone and angiotensin II
    Houcine Dab
    Université de Carthage, Unité de Physiologie Intégrée, Laboratoire de Pathologies Vasculaires, Faculte des Sciences de Bizerte, Tunisia
    J Renin Angiotensin Aldosterone Syst 13:36-45. 2012
    ..Overall, there is a synergic inhibition of both systems on the level of MMP-2 in AA...
  62. ncbi Contrary regulation of TIMP-1 and MMP-9 by hepatocyte growth factor antibody after lung injury
    Yu Wei-Wei
    Institute of General Department, Tongji Hospital, Tongji Medical College, Huazhong, China
    Chin Med Sci J 26:216-20. 2011
    ..To study the influence of hepatocyte growth factor (HGF) antibody on the lung expression level of matrix metalloproteinases-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1)...
  63. doi Effect of hormone replacement therapy in matrix metalloproteinase expression and intimal hyperplasia development after vascular injury
    Deidra J H Mountain
    Department of Surgery, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA
    Ann Vasc Surg 27:337-45. 2013
    ..Herein we study the role of HRT in the development of IH in a postmenopausal rodent model of vascular injury and in the modulation of this MMP regulatory pathway in vivo...
  64. ncbi Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas
    A Nakano
    Department of Neurosurgery, Hyogo College of Medicine, Japan
    J Neurosurg 83:298-307. 1995
    ..The concomitant overexpression of gelatinase A, gelatinase B, and occasional matrilysin genes was associated with the malignancy of gliomas and accompanied by ..
  65. doi Characterization of fibrosis-promoting factors and siRNA-mediated therapies in C-protein-induced experimental autoimmune myocarditis
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Cell Immunol 279:70-7. 2012
    ..These findings suggest that in case of diseases characterized by initial inflammation and subsequent fibrosis, immunotherapies should target inflammation, not fibrosis, because the latter therapies exacerbate inflammation...
  66. ncbi Expression and in-situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer
    T M Gress
    Department of Internal Medicine I, University of Ulm, Germany
    Int J Cancer 62:407-13. 1995
    ..Both stromal and tumor cells appear to be the source of MMPs and TIMPs in human pancreatic cancer...
  67. ncbi Macrophage migration inhibitory factor up-regulates matrix metalloproteinase-9 and -13 in rat osteoblasts. Relevance to intracellular signaling pathways
    Shin Onodera
    Department of Orthopaedics, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Biol Chem 277:7865-74. 2002
    ..Taken together, these results suggest that MIF increases the MMP-13 mRNA level of rat osteoblasts via the Src-related tyrosine kinase-, Ras-, ERK1/2-, and AP-1-dependent pathway...
  68. ncbi Induced expression of MMP-9 in C6 glioma cells is inhibited by PDGF via a PI 3-kinase-dependent pathway
    Pierre Olivier Esteve
    INRS Institut Armand Frappier, Universite du Quebec, 531 Boulevard des Prairies, Laval, Quebec, Canada H7V 1B7
    Biochem Biophys Res Commun 296:864-9. 2002
    ..Taken together, these results suggest that PI 3-kinase may act as a negative regulator of MMP-9 expression in C6 glioma cells...
  69. ncbi Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-kappaB, AP-1 and Sp1
    Terumi Takahra
    Third Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930 0194, Toyama, Japan
    Int J Biochem Cell Biol 36:353-63. 2004
    ..It is concluded that 3D contact of activated HSC with collagen I stimulates MMP-9 expression by elevating NF-kappaB and AP-1 activities which are able to overcome the repressive influence of Sp1/Sp3 on MMP-9 gene transcription...
  70. ncbi Matrix metalloproteinase-9 promotes nerve growth factor-induced neurite elongation but not new sprout formation in vitro
    Veronica I Shubayev
    San Diego VA Healthcare System, San Diego, California, USA
    J Neurosci Res 77:229-39. 2004
    ..These findings suggest that MMP-9 regulates neurite extension in regenerating peripheral nerve fibers and, therefore, might be of therapeutic value in promoting regeneration in vivo...
  71. ncbi The effect of hindlimb immobilization on acid phosphatase, metalloproteinases and nuclear factor-kappaB in muscles of young and old rats
    Marina Bar-Shai
    Department of Anatomy and Cell Biology, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Haifa 31096, Israel
    Mech Ageing Dev 126:289-97. 2005
    ..In conclusion, it seems that the kinetics of activation of extracellular hydrolytic and proteolytic systems differ in muscles of old animals compared to young animals...
  72. ncbi Enhanced matrix metalloproteinase activity in skeletal muscles of rats with congestive heart failure
    Hanne M Schiøtz Thorud
    Institute for Experimental Medical Research, Ullevaal University Hospital, Oslo, Norway
    Am J Physiol Regul Integr Comp Physiol 289:R389-R394. 2005
    ..We conclude that development of CHF in rats enhances MMP activity, which in turn may distort the normal contractile function of skeletal muscle, thereby contributing to increased skeletal muscle fatigue...
  73. ncbi Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques
    Perttu J Pöllänen
    Laboratory of Atherosclerosis Genetics, FinnMedi 2, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, P O Box 2000, 33521 Tampere, Finland
    Atherosclerosis 180:73-8. 2005
    Matrix metalloproteinases 3 and 9 (MMP3 and MMP9) are present in atherosclerotic plaques and co-operate in the degradation of the fibrous cap of the atheroma, leading to fissuring and ultimately to acute coronary thrombosis...
  74. ncbi Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification
    Jesus Alvarez
    Departamento de Morfologia y Biologia Celular, Instituto Universitario de Oncologia del Principado de Asturias IUOPA, Universidad de Oviedo, Oviedo, Asturias, Spain
    J Bone Miner Res 20:1011-21. 2005
    ..MMPs were widely expressed during ossification of the secondary center, whereas expression of VEGF was restricted to later stages...
  75. ncbi L-arginine attenuates acute pulmonary embolism-induced increases in lung matrix metalloproteinase-2 and matrix metalloproteinase-9
    Debora C Souza-Costa
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Chest 128:3705-10. 2005
    ..To evaluate the effects of L-arginine on acute pulmonary embolism (APE)-induced pulmonary hypertension and increases in lung matrix metalloproteinase (MMP)-2 and MMP-9 activities...
  76. pmc TIMP-1/MMP-9 imbalance in brain edema in rats with fulminant hepatic failure
    Satoshi Yamamoto
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Surg Res 134:307-14. 2006
    ..We thus hypothesized that an imbalance in TIMP-1/MMP-9 relationship plays a role in the development of increased brain extravasation and edema in FHF...
  77. ncbi Effects of rosiglitazone alone and in combination with atorvastatin on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus
    Chih Sheng Chu
    The Section of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Taiwan
    Am J Cardiol 97:646-50. 2006
    ....
  78. pmc Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution
    Kengo Manase
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, South 1 West 16, Chuou ku, Sapporo 060 8543, Japan
    Reprod Biol Endocrinol 4:32. 2006
    ..To understand the expression patterns of matrix metalloproteinases (MMPs) in the rat uterus, we analyzed their activities in postpartum uterine involution...
  79. ncbi Sendai virus infection up-regulates trypsin I and matrix metalloproteinase-9, triggering viral multiplication and matrix degradation in rat lungs and lung L2 cells
    H Yamada
    Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima, Japan
    Arch Virol 151:2529-37. 2006
    ..Up-regulation of proMMP-9 and its active convertase trypsin I seems to synergistically enhance virus multiplication and the destruction of lung matrix, resulting in the progression of pneumonia...
  80. ncbi Effect of experimental genital mycoplasmosis on production of matrix metalloproteinases in membranes and amniotic fluid of Sprague-Dawley rats
    Morgan R Peltier
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Medicine and Dentistry, New Brunswick, NJ 08901, USA
    Am J Reprod Immunol 57:116-21. 2007
    ..We tested this hypothesis in a well-defined model system of genital infection with M. pulmonis, a natural reproductive pathogen of rats...
  81. ncbi Effect of respiratory syncytial virus on the activity of matrix metalloproteinase in mice
    Wen Li
    Department of Respiratory Medicine, Second Affiliated Hospital, Zhejiang University College of Medicine, Institute of Respiratory Diseases Zhejiang University, Hangzhou 310009, China
    Chin Med J (Engl) 120:5-11. 2007
    ..This study was undertaken to examine the effect of infection with RSV on matrix metalloproteinase (MMPs) in mice, and to explore the role of RSV in the pathogenesis of pulmonary diseases...
  82. ncbi [Correlation between matrix metalloproteinases activities and myocardial injury in neonatal rats after asphyxia]
    Shu Zhen Xu
    Department of Pediatrics, Qingdao Municipal Hospital, Qingdao 266011, China
    Zhonghua Er Ke Za Zhi 45:134-7. 2007
    ..To study possible correlation between matrix metalloproteinases (MMPs) activities and myocardial injury after asphyxia in neonatal Wistar rats...
  83. ncbi [Effect of curcumin on activity of matrix metalloproteinase 2, 9 and nuclear expression of RelA in rat hepatic stellate cells by activating peroxisome proliferator-activated receptor gamma signal]
    Yang Cheng
    Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai
    Zhongguo Zhong Xi Yi Jie He Za Zhi 27:439-43. 2007
    ....
  84. ncbi Visible light induces matrix metalloproteinase-9 expression in rat eye
    Andrea M Papp
    Laboratory of Proteomics, Institute of Biology, Eotvos Lorand University, Budapest, Hungary
    J Neurochem 103:2224-33. 2007
    Up-regulation of matrix metalloproteinase-9 (MMP-9, gelatinase B) in the nervous system has been demonstrated when excitotoxicity-induced tissue remodeling and neuronal death occurs...
  85. pmc The extracellular protease matrix metalloproteinase-9 is activated by inhibitory avoidance learning and required for long-term memory
    Vanja Nagy
    Fishberg Department of Neuroscience, The Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Learn Mem 14:655-64. 2007
    ....
  86. ncbi Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage
    Michael Hultström
    Renal Research Group, Department of Medicine, Haukeland University Hospital, Bergen, Norway
    Nephrol Dial Transplant 23:896-903. 2008
    ....
  87. ncbi [mRNA expression analysis of metastatic markers in clear-cell renal cell carcinoma]
    K Struckmann
    Institut für Klinische Pathologie, Universitatsspital Zurich, Schweiz
    Verh Dtsch Ges Pathol 89:178-83. 2005
    ..04 and p = 0.01, respectively). These preliminary results suggest the involvement of CXCR4, MMP-2, and MMP-9 in renal cancer progression...
  88. pmc Matrix metalloproteinase-2, -9 and -13 are involved in fibronectin degradation of rat lung granulomatous fibrosis caused by Angiostrongylus cantonensis
    Cheng Chin Hsu
    School of Nutrition, Chung Shan Medical University, Taichung, Taiwan
    Int J Exp Pathol 88:437-43. 2007
    ..These results suggest that MMP-2, -9 and -13 may participate in the fibronectin degradation of A. cantonensis-induced granulomatous fibrosis...
  89. doi Prognostic significance of MMP-9 and TIMP-1 serum and tissue expression in breast cancer
    Zheng Sheng Wu
    Department of Pathology, Anhui Medical University, Hefei, Anhui, People s Republic of China
    Int J Cancer 122:2050-6. 2008
    ..Our findings suggest that MMP-9 and TIMP-1 may further be evaluated as biomarkers for predicting progression and prognosis of breast cancer...
  90. doi Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury
    Guillermo M Albaiceta
    Department of Biologia Functional, Universidad de Oviedo, and Intensive Care Unit, Hospital Universitario Central de Asturias, Celestino Villamil s n, 33006 Oviedo, Spain
    Am J Physiol Lung Cell Mol Physiol 294:L535-43. 2008
    ..Cell count and myeloperoxidase activity were measured in BALF. There were no differences between wild-type and Mmp9-/- animals after low-pressure ventilation...
  91. doi Morphologic evaluation and expression of matrix metalloproteinases-2 and 9 and nitric oxide during experimental periodontal disease in rat
    Camila Oliveira Rodini
    Department of Stomatology Oral Pathology, Bauru School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil
    J Mol Histol 39:275-82. 2008
    ..Also, we may suggest that the exuberant presence of PMNs may be related to the important expression of iNOS and MMP-9 found at 3 days post induction...
  92. ncbi [Role of MMP-9 and TIMP-1 in renal tubular epithelial-myofibroblast transdifferentiation]
    Hen Xue
    Department of Nephrology, West China Hosipital, Shichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 39:34-8. 2008
    ..To investigate the dynamic changes of MMP-9 and TIMP-1 expressions in rat unilateral ureteral obstruction (UUO) model, and to explore the role of MMP-9 and TIMP-1 in tubular epithelialmyofibroblast transdifferentiation...
  93. pmc Role of matrix metalloprotease-9 in hyperoxic injury in developing lung
    Anne Chetty
    Dept of Pediatrics, Tufts Medical Center, Boston, MA 02111, USA
    Am J Physiol Lung Cell Mol Physiol 295:L584-92. 2008
    ..MMP-9 plays an important role in the structural changes consequent to oxygen-induced lung injury. Blocking MMP-9 activity may lead to novel therapeutic approaches in preventing bronchopulmonary dysplasia...
  94. pmc Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients
    Mei Tian
    Key Laboratory of Ministry of Health for Biotech Drug, Key Laboratory for Modern Medicine and Technology of Shandong Province, Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan 250062, PR China
    BMC Cancer 8:241. 2008
    ..Pancreatic juice is an ideal specimen for PDAC biomarkers discovery, because it is an exceptionally rich source of proteins released from pancreatic cancer cells...
  95. doi Regulation of matrix metalloproteinase-9 expression between gingival fibroblast cells from old and young rats
    Su Jung Kim
    Department of Orthodontics, Kyung Hee University School of Dentistry, Hoegi dong 1, Dongdaemoon Ku, Seoul, Republic of Korea
    Biochem Biophys Res Commun 378:152-6. 2009
    ..These results suggest that cell cycle dysregulation and down-regulation of MMP-9 expression in rGF may play a role in gingival remodeling during in vitro aging...
  96. pmc Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9
    Xue Qing Wang
    Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    Mol Biol Cell 20:791-800. 2009
    ....
  97. doi Metalloproteinases 2 and 9 activity during promotion and progression stages of rat liver carcinogenesis
    Kelly Silva Furtado
    School of Medicine, Department of Pathology, UNESP Sao Paulo State University, Botucatu, SP 18618 000, Brazil
    J Mol Histol 40:1-11. 2009
    ..Our findings suggest that MMP-2 may be associated with proliferative events induced by 2-AAF rather than with selective growth of PNL and that MMP-9 could be associated with progression of PNL and neoplastic mixed lesions...
  98. pmc MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway
    Sharmila Chattopadhyay
    Department of Anesthesiology, University of California, San Diego, California 92093 0629, USA
    Glia 57:1316-25. 2009
    ..We also report on the early changes of MMP-9 mRNA expression (within 24 h) after axotomy. These studies establish that MMP-9 controls critical trophic signal transduction pathways and phenotypic remodeling of Schwann cells...
  99. pmc Synapse loss regulated by matrix metalloproteinases in traumatic brain injury is associated with hypoxia inducible factor-1alpha expression
    Jamie Y Ding
    Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Brain Res 1268:125-34. 2009
    ..The data also supports a role for HIF-1alpha in the MMP regulatory cascade in synapse loss after TBI, suggesting potential targets for reducing loss of synaptic terminals...
  100. pmc Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract
    Sang Eun Kim
    Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Suwon 440 746, Korea
    Exp Mol Med 41:277-87. 2009
    ....

Research Grants12

  1. LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERS
    Jenny Mao; Fiscal Year: 2007
    ..The finding from this pilot project will provide important insight into the design and conduct of future chemopreventive trials. ..
  2. Mechanism of Endothelial Dysfunction in Diabetes
    Adviye Ergul; Fiscal Year: 2004
    ..The results will lead to the development of novel therapeutic targets for the high-risk diabetic patients and may identify subgroups of patients that would be more suitable for these new treatment strategies. ..
  3. MMP-9-Dependent Vessel Wall Remodeling is NO-Dependent
    Gilbert Upchurch; Fiscal Year: 2005
    ..Given recent evidence that MMP-9 (alternatively known as the 92 kD gelatinase or gelatinase B) plays a key role in aneurysm development in vivo, special emphasis will be placed on interactions between NO ..
  4. Oxidative Mechanisms of Arsenic-induced Carcinogenesis
    Ke Liu; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  5. Thrombus resolution is CXC chemokine dependent
    Peter Henke; Fiscal Year: 2006
    ..abstract_text> ..
  6. Cerebrovascular mechanisms of ischemic injury in diabetes
    Adviye Ergul; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. ACT,a pathophysiological inhibitor of MMP-9 activation
    Yuan Ping Han; Fiscal Year: 2008
    ..Understanding the function, structure and regulation of the inhibitor can provide information for future application in developing of therapy for abnormal wounds and cancer metastasis. ..
  8. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. Hepatic Stellate Cell Derived MMP9 in Liver Fibrogenesis
    Yuan Ping Han; Fiscal Year: 2008
    ..serve as potent dual signals to provoke and perpetuate early HSC activation via induction and activation of pro-MMP9 and MMP-13 while the loss of this MMP inducibility in fully-activated HSC underlie progressive fibrogenesis...
  10. Vein wall remodeling after DVT is matrix metalloproteinase dependent
    Peter Henke; Fiscal Year: 2009
    ..This proposal will provide important mechanistic insight into the pathophysiology of post-phelbitic syndrome with real potential translation to decreasing the morbidity from this under-acknowledged disease. ..
  11. INTEGRATIVE PROGRAM IN CNS PATHOPHYSIOLOGY RESEARCH
    Ke Jian Liu; Fiscal Year: 2010
    ..abstract_text> ..
  12. Vascular Protection & Endothelin B Receptors in Diabetes
    Adviye Ergul; Fiscal Year: 2009
    ..abstract_text> ..