Mmp3

Summary

Gene Symbol: Mmp3
Description: matrix metallopeptidase 3
Alias: stromelysin-1, MMP-3, PTR1 protein, SL-1, matrix metalloproteinase-3, transin-1
Species: rat

Top Publications

  1. pmc Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death
    Dong Hee Choi
    Neurology Neuroscience Department, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Biol Chem 286:14168-77. 2011
  2. ncbi The 5A/6A polymorphism of the matrix metalloproteinase 3 gene promoter and breast cancer
    Peter Krippl
    Department of Internal Medicine, Division of Oncology, Medical University Graz, Graz, Austria
    Clin Cancer Res 10:3518-20. 2004
  3. ncbi Activation of matrix metalloproteinase-3 and agrin cleavage in cerebral ischemia/reperfusion
    Sonia Sole
    Departament de Farmacologia i Toxicologia, IIBB CSIC, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    J Neuropathol Exp Neurol 63:338-49. 2004
  4. pmc Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion
    Daniel J Leong
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Matrix Biol 29:420-6. 2010
  5. ncbi Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma
    Hiroshi Hirata
    Department of Urology, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Carcinogenesis 25:2379-84. 2004
  6. ncbi Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases
    Jee Young Sung
    Department of Biology, College of Science, Yonsei University, Seoul 120 749, Korea
    J Biol Chem 280:25216-24. 2005
  7. ncbi Elevation of hippocampal MMP-3 expression and activity during trauma-induced synaptogenesis
    H J Kim
    Department of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University Medical Center, Medical Sciences Building Room 736, 1217 E Marshall Street, PO Box 980709, Richmond, VA 23298, USA
    Exp Neurol 192:60-72. 2005
  8. pmc Polymorphism of matrix metalloproteinase-3 promoter gene as a risk factor for coronary artery lesions in Kawasaki disease
    Jeong Ah Park
    Department of Pediatrics, Seoul National University College of Medicine, Korea
    J Korean Med Sci 20:607-11. 2005
  9. doi Prolonged upright posture induces degenerative changes in intervertebral discs of rat cervical spine
    Qian Qian Liang
    Department of Orthopaedics and Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People s Republic of China
    Spine (Phila Pa 1976) 36:E14-9. 2011
  10. pmc Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats
    Guo Xin Ni
    Department of Orthopeadics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou Road 1838, 510515, Guangzhou, China
    Arthritis Res Ther 13:R192. 2011

Research Grants

Scientific Experts

Detail Information

Publications90

  1. pmc Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death
    Dong Hee Choi
    Neurology Neuroscience Department, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Biol Chem 286:14168-77. 2011
    ..Our previous results showed that an endopeptidase, matrix metalloproteinase-3 (MMP3), was induced and activated in dopaminergic (DA) cells upon stress conditions...
  2. ncbi The 5A/6A polymorphism of the matrix metalloproteinase 3 gene promoter and breast cancer
    Peter Krippl
    Department of Internal Medicine, Division of Oncology, Medical University Graz, Graz, Austria
    Clin Cancer Res 10:3518-20. 2004
    The matrix metalloproteinase 3 (MMP3), also known as stromelysin-I, is a key-player for carcinogenesis and tumor growth...
  3. ncbi Activation of matrix metalloproteinase-3 and agrin cleavage in cerebral ischemia/reperfusion
    Sonia Sole
    Departament de Farmacologia i Toxicologia, IIBB CSIC, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    J Neuropathol Exp Neurol 63:338-49. 2004
    ..In addition, the finding that MMP-3 cleaves brain agrin strongly suggests that ischemia-induced MMP-3 activation causes agrin cleavage...
  4. pmc Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion
    Daniel J Leong
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Matrix Biol 29:420-6. 2010
    ..These results suggest that biomechanical forces have the potential to combat cartilage destruction and can be critical in developing effective therapeutic strategies...
  5. ncbi Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma
    Hiroshi Hirata
    Department of Urology, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Carcinogenesis 25:2379-84. 2004
    ..95, CI = 1.31-2.91). These findings suggest that this haplotype of MMP-1 and MMP-3 variants may be associated with the risk of developing RCC...
  6. ncbi Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases
    Jee Young Sung
    Department of Biology, College of Science, Yonsei University, Seoul 120 749, Korea
    J Biol Chem 280:25216-24. 2005
    ..The present study suggests that the extracellularly secreted alpha-synuclein could be processed via the activation of MMP-3 in a selective manner...
  7. ncbi Elevation of hippocampal MMP-3 expression and activity during trauma-induced synaptogenesis
    H J Kim
    Department of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University Medical Center, Medical Sciences Building Room 736, 1217 E Marshall Street, PO Box 980709, Richmond, VA 23298, USA
    Exp Neurol 192:60-72. 2005
    ..Notably, these effects are both transcriptional and translational and are correlated with functionally active enzyme...
  8. pmc Polymorphism of matrix metalloproteinase-3 promoter gene as a risk factor for coronary artery lesions in Kawasaki disease
    Jeong Ah Park
    Department of Pediatrics, Seoul National University College of Medicine, Korea
    J Korean Med Sci 20:607-11. 2005
    ..0036). However, no significant differences in the allele and genotype distributions of the MMP-9 polymorphism were observed. These findings suggest that MMP-3 6A/6A genotype may be an independent risk factor for CAL formation in KD...
  9. doi Prolonged upright posture induces degenerative changes in intervertebral discs of rat cervical spine
    Qian Qian Liang
    Department of Orthopaedics and Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People s Republic of China
    Spine (Phila Pa 1976) 36:E14-9. 2011
    ..An in vivo study of the cervical intervertebral discs (IVDs) response to upright posture was performed using an amputated bipedal rat model...
  10. pmc Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats
    Guo Xin Ni
    Department of Orthopeadics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou Road 1838, 510515, Guangzhou, China
    Arthritis Res Ther 13:R192. 2011
    ..The effect of intra-articular injection of matrix metalloproteinase (MMP)-3 inhibitor was investigated in a rat model to understand the role of MMP-3 in cartilage degradation induced by excessive loading from running...
  11. pmc Myelin loss associated with neuroinflammation in hypertensive rats
    Fakhreya Y Jalal
    Department of Neurology, MSC10 5620, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Stroke 43:1115-22. 2012
    ..Therefore, we used spontaneously hypertensive stroke-prone rats to study the role of neuroinflammation in white matter damage...
  12. doi Full and partial peroxisome proliferation-activated receptor-γ agonists, but not δ agonist, rescue of dopaminergic neurons in the 6-OHDA parkinsonian model is associated with inhibition of microglial activation and MMP expression
    M Sadeghian
    Parkinson s Disease Research Group, Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Imperial College London, UK
    J Neuroimmunol 246:69-77. 2012
    ..However, no studies have looked at the effects of partial PPARγ agonists...
  13. pmc Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism
    C A Christianson
    Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, MC 0818, La Jolla, CA 92093 0818, USA
    Neuroscience 200:199-210. 2012
    ..These findings thus present direct evidence implicating MMP-3 in the coordination of spinal nociceptive processing via a spinal TNF-dependent mechanism...
  14. doi Imbalance of matrix metalloproteinases/tissue inhibitor of metalloproteinase-1 and loss of fibronectin expression in patients with congestive heart failure
    Da chun Yang
    Department of Cardiology, General Hospital of PLA Chengdu Military Area Command, Chengdu, China
    Cardiology 116:133-41. 2010
    ..The present study was designed to examine this issue in patients with congestive heart failure (CHF)...
  15. ncbi Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model
    Odete Mendes
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Clin Exp Metastasis 22:237-46. 2005
    In order to study the expression of MMP2, MMP3 and MMP9 in breast cancer brain metastasis, we used a syngeneic rat model of distant metastasis of ENU1564, a carcinogen-induced mammary adenocarcinoma cell line...
  16. doi Zucker diabetic fatty rat: a new model of impaired cutaneous wound repair with type II diabetes mellitus and obesity
    Rastislav Slavkovsky
    Laboratory of Wound healing, CPN, Dolni Dobrouc, Czech Republic
    Wound Repair Regen 19:515-25. 2011
    ..Taken together, Zucker diabetic fatty rats exhibited impairments in wound-size reduction, inflammatory response, tissue organization, and connective tissue turnover and are thus proposed as a new model for studying impaired repair...
  17. pmc Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, Salt Lake City, UT 84143, USA
    Am Heart J 154:751-8. 2007
    ..Furthermore, differentiation of predictive ability by end point (MI vs CAD) has not been addressed. This study evaluated the association with MI of SNPs in genes encoding MMPs 1, 2, 3, and 9 and TIMPs 1, 2, and 3...
  18. doi Matrix metalloproteinase and cytokine expression in Tenon fibroblasts during scar formation after glaucoma filtration or implant surgery in rats
    Momoko Nakamura-Shibasaki
    Department of Ophthalmology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima City, Hiroshima, Japan
    Cell Biochem Funct 31:482-8. 2013
    ..These results thus suggest that the expression of MMP-1 and MMP-3 in Tenon fibroblasts is regulated by IL-6 during, and may play an important role in, scar formation after glaucoma surgery...
  19. doi Long-Term Selenium-Deficient Diet Induces Liver Damage by Altering Hepatocyte Ultrastructure and MMP1/3 and TIMP1/3 Expression in Growing Rats
    Jing Han
    School of Public Health, Health Science Center, Xi an Jiaotong University, Xi an, Shaanxi, 710061, People s Republic of China
    Biol Trace Elem Res 175:396-404. 2017
    ..In conclusion, Se-deficient diet could cause low Se concentration in the liver, alterations of hepatocyte ultrastructure, differential expressions of MMP1/3 and TIMP1/3 as well as fibrosis in the liver hepatic periportal...
  20. doi Novel phosphoinositide 3-kinase δ,γ inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis
    David L Boyle
    Division of Rheumatology, Allergy, and Immunology, School of Medicine, University of California San Diego, La Jolla, California
    J Pharmacol Exp Ther 348:271-80. 2014
    ..These data show that PI3Kδ,γ inhibition suppresses inflammatory arthritis, as well as bone and cartilage damage, through effects on innate and adaptive immunity and that IPI-145 is a potential therapy for RA. ..
  21. doi Therapeutic effects of p75 tumor necrosis factor receptor monoclonal antibody on a rat model of traumatic arthritis
    Yi Xin Wang
    First aid Center, Shanghai Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
    J Surg Res 186:234-9. 2014
    ..The aim of the present study was to investigate the therapeutic effects of p75 tumor necrosis factor receptor monoclonal antibody D8F2 on a traumatic arthritis model in rats, and to explore the underlying mechanism...
  22. doi Autoantibody and biopsy grading are associated with expression of ICAM-1, MMP-3, and TRAIL in salivary gland mononuclear cells of Chinese patients with Sjogren's syndrome
    Wei Sheng Chen
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Beitou District, Taipei, Taiwan
    J Rheumatol 36:989-96. 2009
    ..Sjögren's syndrome (SS) is an inflammatory autoimmune disease. We investigated important factors associated with the expression of inflammation-related molecules in minor salivary gland (MSG) mononuclear cells in patients with SS...
  23. ncbi Expression of matrix metalloproteinases and their inhibitor TIMP-1 in the rat carotid artery after balloon injury
    K E Webb
    Centre for Genetics of Cardiovascular Disorders, University College London Medical School, Rayne Institute, United Kingdom
    Arterioscler Thromb Vasc Biol 17:1837-44. 1997
    ....
  24. doi The role of oxidative stress and inflammation in conjunctivochalasis
    Samantha K Ward
    Keio University School of Medicine, Johnson and Johnson Ocular Surface and Visual Optics Department, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:1994-2002. 2010
    ..Increased tear inflammation seemed to coexist with loss of conjunctival epithelial cohesiveness and increased collagenolytic activity, which may explain the conjunctival laxity observed in patients with conjunctivochalasis...
  25. pmc Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis
    Yury Popov
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Gastrointest Liver Physiol 298:G323-34. 2010
    ....
  26. ncbi The association of serum matrix metalloproteinases and their tissue inhibitor levels with scleroderma disease severity
    E Toubi
    Division of Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion Haifa, Israel
    Clin Exp Rheumatol 20:221-4. 2002
    b>Matrix metalloproteinase 3 (MMP-3) is reported to play an important role in the pathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)...
  27. pmc MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3
    Xuguang Zheng
    Department of Neurology, Henry Ford Hospital, Detroit, MI, USA
    Cancer Lett 329:146-54. 2013
    ..In vitro tube formation assay data showed that miR-15b reduced tube formation. A preliminary pathway study indicated that miR-15b and miR-152 deactivated the MEK-ERK pathway via NRP-2 and MMP-3 in 9L cells, respectively...
  28. ncbi Diagnosis and assessment of Takayasu arteritis by multiple biomarkers
    Takashi Ishihara
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ J 77:477-83. 2013
    ..There is a report that matrix metalloproteinase (MMP)-2, MMP-3, MMP-9 and pentraxin3 (PTX3) could be sensitive biomarkers, but the characteristics of these biomarkers have not been established...
  29. pmc Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis
    Penelope A Bradbury
    Medical Oncology and Hematology, Biostatistics, Princess Margaret Hospital and Department of Medicine, Dalla Lama School of Public Health and University of Toronto, Ontario, Canada
    Carcinogenesis 30:793-8. 2009
    ..A total of 313 EA cases and 455 age and gender frequency-matched controls were genotyped for MMP1 1G/2G, MMP3 6A/5A, MMP12 -82A/G and MMP12 1082A/G...
  30. pmc Functional polymorphisms in matrix metalloproteinases-1, -3, -9 are associated with arteriovenous fistula patency in hemodialysis patients
    Chih Ching Lin
    School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    Clin J Am Soc Nephrol 5:1805-14. 2010
    ..This study evaluated the association of genotype polymorphisms of MMPs and tissue inhibitors of metalloproteinases (TIMPs) in hemodialysis (HD) patients with arteriovenous fistula (AVF) failure...
  31. pmc Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma
    Christopher Ricketts
    Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK
    PLoS ONE 4:e6037. 2009
    ..Hence we hypothesised that low-penetrance functional genetic variants in pathways related to the VHL protein (pVHL) function might (a) modify the phenotypic expression of VHL disease and/or (b) predispose to sporadic RCC...
  32. pmc Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma
    Astrid Lievre
    INSERM U775 et Université René Descartes, Paris, France
    BMC Cancer 6:270. 2006
    Matrix metalloproteinases (MMP) have been shown to play a role in colorectal cancer (CRC). More recently, MMP1, MMP3 and MMP7 functional gene promoter polymorphisms have been found to be associated with CRC occurrence and prognosis...
  33. ncbi [Effect of progesterone on MMP-3 expression in neonatal rat brain after hypoxic-ischemia]
    Chun yang Xu
    Department of Physiology, Xinxiang Medical College, Xinxiang 453003, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 26:370-3. 2010
    ..To study the effect of progesterone on matrix metalloproteinase-3 (MMP-3) expression in neonatal rat brain after hypoxic-ischemia...
  34. ncbi Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis
    Daniel Henri Manicourt
    Department of Rheumatology, Universite Catholique de Louvain, Saint Luc University Hospital Saint Luc, Brussels, Belgium
    Drugs R D 6:261-71. 2005
    ....
  35. ncbi Matrix metalloproteinases and mesangial remodeling in light chain-related glomerular damage
    John Keeling
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Kidney Int 68:1590-603. 2005
    ..Alterations of the mesangial ECM in AL-amyloidosis (AL-Am) and light chain deposition disease (LCDD) are crucial in their pathogeneses as two divergent entities...
  36. ncbi Levels of circulating collagenase, stromelysin-1, and tissue inhibitor of matrix metalloproteinases 1 in patients with rheumatoid arthritis. Relationship to serum levels of antigenic keratan sulfate and systemic parameters of inflammation
    D H Manicourt
    Saint Luc University Hospital, University of Louvain, Brussels, Belgium
    Arthritis Rheum 38:1031-9. 1995
    ....
  37. ncbi Expression of matrix metalloproteinase-9 associated with ets-1 proto-oncogene in rat tubulointerstitial cells
    Takashi Naito
    Department of Medicine, Tokyo Women s Medical University Daini Hospital, Arakawaku, Tokyo, Japan
    Nephrol Dial Transplant 20:2333-48. 2005
    ..However, the role of the Ets-1-MMP axis in advanced renal diseases is uncertain. In the present study, we investigated whether Ets-1 is involved in interleukin (IL)-1-mediated expression of MMPs in tubulointerstitial cells...
  38. doi Impaired biomechanical properties correlate with neoangiogenesis as well as VEGF and MMP-3 expression during rat patellar tendon healing
    Hacer Sahin
    Department of Trauma, Hand and Reconstructive Surgery, WWU Muenster, Germany
    J Orthop Res 30:1952-7. 2012
    ..The therapeutical modulation of neoangiogenesis by influencing the level of VEGF and MMP-3 might be a promising target for new approaches in degenerative tendon diseases. 30:1952-1957, 2012...
  39. ncbi Changes in matrix metalloproteinases and their inhibitors in kidney transplant recipients
    Aimun K Ahmed
    Department of Renal Medicine, Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom
    Exp Clin Transplant 10:332-43. 2012
    ..This study sought to determine if a change in the matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases system contributes to chronic allograft nephropathy-associated progressive kidney scarring...
  40. doi Angiotensin II induces the production of MMP-3 and MMP-13 through the MAPK signaling pathways via the AT(1) receptor in osteoblasts
    Kumiko Nakai
    Division of Oral Health Sciences, Nihon University Graduate School of Dentistry, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Biochimie 95:922-33. 2013
    ..Furthermore, our findings suggest that Ang II does not influence the plasminogen/plasmin pathway in osteoblasts...
  41. pmc MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis
    I Tchetverikov
    TNO Prevention and Health, PO Box 2215, 2301 CE, Leiden, The Netherlands
    Ann Rheum Dis 63:881-3. 2004
    ....
  42. pmc Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    PLoS Med 3:e100. 2006
    ..The pathological mechanisms by which such mutations lead to eventual kidney failure are not completely understood...
  43. pmc Retinoic acid and the transcription factor MafB act together and differentially to regulate aggrecan and matrix metalloproteinase gene expression in neonatal chondrocytes
    Yao Zhang
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Cell Biochem 114:471-9. 2013
    ..These results support a role for MafB as a regulator of chondrocyte gene expression and matrix formation via control of aggrecan, MMP3 and MMP13 expression, and indicate an important role for RA in the regulation of MafB.
  44. pmc Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment
    C Ribbens
    Department of Rheumatology, University of Liege, Belgium
    Ann Rheum Dis 61:161-6. 2002
    ..To determine matrix metalloproteinase-3 (MMP-3) serum levels in patients with rheumatic diseases and to study the relation between MMP-3 and C reactive protein (CRP) levels...
  45. ncbi Renal expression of the Ets-1 proto-oncogene during progression of rat crescentic glomerulonephritis
    T Naito
    Second Department of Pathology, Nagasaki University School of Medicine, Nagasaki, Japan
    J Am Soc Nephrol 11:2243-55. 2000
    ..These results indicate that overexpression of the ets-1 proto-oncogene by phenotypically altered renal cells might be associated with the pathogenesis of rat crescentic glomerulonephritis...
  46. ncbi In situ hybridization studies of matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-1 and type IV collagen in diabetic nephropathy
    D Suzuki
    Department of Internal Medicine, School of Medicine, Tokai University, Kanagawa, Japan
    Kidney Int 52:111-9. 1997
    ..Altered expression of MMP-3 and TIMP-1 may be associated with the progression of DN...
  47. doi Matrix metalloproteinase (MMP)-3 gene up-regulation in a rat tail compression loading-induced disc degeneration model
    Takashi Yurube
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Orthop Res 28:1026-32. 2010
    ..This model should prove useful for investigating the pathomechanism and for evaluating molecular therapies for degenerative disc disease...
  48. doi Increased MMP-3 and CTGF expression during lipopolysaccharide-induced dopaminergic neurodegeneration
    Justin A McClain
    Virginia Commonwealth University, Department of Physiology and Biophysics, United States
    Neurosci Lett 460:27-31. 2009
    ..The temporal changes in MMP-3 and CTGF expression corresponded to the neurodegenerative phase of this model, suggesting that these two proteins may participate in neuroinflammation-induced DA neurotoxicity...
  49. pmc Matrix metalloproteinase-3 accelerates wound healing following dental pulp injury
    Li Zheng
    Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Aichi, Japan
    Am J Pathol 175:1905-14. 2009
    ..These results provide suggestive evidence that MMP-3 released from endothelial cells and/or endothelial progenitor cells in injured pulp plays critical roles in angiogenesis and pulp wound healing...
  50. pmc Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus
    Louise A Russo
    Villanova University Department of Biology, 800 Lancaster Avenue, Villanova, PA 19085, USA
    Reprod Biol Endocrinol 7:124. 2009
    ....
  51. ncbi [Establishment and analysis of chronic periodontitis and atherosclerosis model in Wistar rat]
    Liang Jun Zhong
    Department of Stomatology, Xinjiang Medical University, Urumqi 830054, China
    Zhonghua Kou Qiang Yi Xue Za Zhi 44:464-8. 2009
    ..To investigate the possible correlation between atherosclerosis and chronic periodontitis by establishing an animal model of chronic periodontitis and atherosclerosis in Wistar rat...
  52. pmc Pleural fluid analysis of lung cancer vs benign inflammatory disease patients
    R Kremer
    Department of General Thoracic Surgery, Rambam Health Care Campus, Haifa, Israel
    Br J Cancer 102:1180-4. 2010
    ..Correct diagnosis of pleural effusion (PE) as either benign or malignant is crucial, although conventional cytological evaluation is of limited diagnostic accuracy, with relatively low sensitivity rates...
  53. ncbi Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats
    Qian Qian Liang
    Department of Orthopaedics and Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, China
    J Pharmacol Sci 113:23-31. 2010
    ..These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease...
  54. ncbi Expression changes and roles of matrix metalloproteinases in a rat model of traumatic deep vein thrombosis
    Yu bing Zhang
    Department of Orthopaedics, First Affiliated Hospital of Kunming Medical College, China
    Chin J Traumatol 13:188-92. 2010
    ..To study the expression changes of matrix metalloproteinases (MMPs) in traumatic deep vein thrombosis (TDVT) in a rat model with the aid of gene chip technology and to explore the roles of MMPs in TDVT...
  55. pmc Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene
    Takanori Eguchi
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1, Shikata cho, Okayama City, Okayama, Japan
    Mol Cell Biol 28:2391-413. 2008
    b>Matrix metalloproteinase 3 (MMP3) is well known as a secretory endopeptidase that degrades extracellular matrices. Recent reports indicated the presence of MMPs in the nucleus (A. J. Kwon et al., FASEB J...
  56. doi Substrate stiffness regulates apoptosis and the mRNA expression of extracellular matrix regulatory genes in the rat annular cells
    Yue Hui Zhang
    Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, China
    Matrix Biol 30:135-44. 2011
    ....
  57. ncbi Aortic adaptation to pregnancy: elevated expression of matrix metalloproteinases-2 and -3 in rat gestation
    B A Kelly
    Maternal and Fetal Research Unit, Department of Women s Health, Guy s, King s and St Thomas School of Medicine, 10th Floor St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Mol Hum Reprod 10:331-7. 2004
    ..These data suggest that MMP-2 and MMP-3 may contribute to adaptive processes in the maternal rat aorta at different gestations and further support a role for this family of enzymes in physiological vascular remodelling...
  58. ncbi Identification of a calcium-dependent matrix metalloproteinase complex in rat chorioallantoid membranes during labour
    N Meraz-Cruz
    Direccion de Investigacion, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico
    Mol Hum Reprod 12:633-41. 2006
    ..This complex provides a potential mechanism for the enzymatic regulation of MMPs, which may participate in connective tissue degradation leading to the rupture of the fetal membranes during labour...
  59. pmc Regulation of matrix metalloproteinase expression by dynamic tensile strain in rat fibrochondrocytes
    J Deschner
    The Ohio State University, Oral Biology and Orthopedics, 4171 Postle Hall, 305 West 12th Avenue, Columbus, OH 43210, USA
    Osteoarthritis Cartilage 14:264-72. 2006
    ..Furthermore, we examined whether the effects of biomechanical strain on MMP gene expression are sustained...
  60. ncbi Matrix-degrading enzymes tissue plasminogen activator and matrix metalloprotease-3 in the hypothalamo-neurohypophysial system
    Seiji Miyata
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Kyoto, Japan
    Brain Res 1058:1-9. 2005
    ....
  61. ncbi Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques
    Perttu J Pöllänen
    Laboratory of Atherosclerosis Genetics, FinnMedi 2, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, P O Box 2000, 33521 Tampere, Finland
    Atherosclerosis 180:73-8. 2005
    Matrix metalloproteinases 3 and 9 (MMP3 and MMP9) are present in atherosclerotic plaques and co-operate in the degradation of the fibrous cap of the atheroma, leading to fissuring and ultimately to acute coronary thrombosis...
  62. ncbi Expression of matrix metalloproteinase-3 in the rat cervix during pregnancy and in response to prostaglandin E2
    Edward K Chien
    Department of Obstetrics and Gynecology, Section of Maternal Fetal Medicine, University of Vermont, Burlington, VT 05405, USA
    Am J Obstet Gynecol 192:309-17. 2005
    ....
  63. ncbi Peptide YY and neuropeptide Y induce villin expression, reduce adhesion, and enhance migration in small intestinal cells through the regulation of CD63, matrix metalloproteinase-3, and Cdc42 activity
    Mike Lee
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720 3104, USA
    J Biol Chem 280:125-36. 2005
    ....
  64. ncbi Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population. The Beijing atherosclerosis study
    Xiaoyang Zhou
    Division of Popluation Genetics and Prevention, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Thromb Haemost 92:867-73. 2004
    ..Up to now, there has been conflicting data regarding the possible contribution of the MMP3 -1612 5A/6A promoter polymorphism to MI...
  65. ncbi Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis
    Elena Kaschina
    Center for Cardiovascular Research Institute of Pharmacology and Toxicology, Campus Charite Mitte, Charite University Medicine Berlin, 10115 Berlin, Germany
    Physiol Genomics 19:41-9. 2004
    ..These findings suggest that genetic kininogen deficiency renders vascular tissue prone to aneurysmatic but not to atherosclerotic lesions...
  66. ncbi Gene expression profiling of skin and draining lymph nodes of rats affected with cutaneous contact hypersensitivity
    B Hartmann
    Novartis Institutes of Biomedical Research ATDA, Brunnerstrasse 59, 1230, Vienna, Austria
    Inflamm Res 55:322-34. 2006
    ..The present study aimed at a broad genome expression analysis of rat skin and draining lymph nodes affected with allergic contact dermatitis (ACD)...
  67. ncbi Modulation of matrix metalloproteinase-9 in hepatic stellate cells by three-dimensional type I collagen: its activation and signaling pathway
    Terumi Takahara
    Third Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama City, 930 0194, Toyama, Japan
    Hepatol Res 26:318-326. 2003
    ..CONCLUSIONS: MMP-9 expression and activation is induced in HSCs by 3D-gel and this observed collagen-dependent induction of MMP-9 requires ERK1,2 activity...
  68. ncbi Temperospatial expression of matrix metalloproteinases 1, 2, 3, and 9 during early tooth development
    L E Randall
    Department of Basic Dental Science, University of Wales College of Medicine, Dental School, Heath Park, Cardiff, CF4 4XY, United Kingdom
    Connect Tissue Res 43:205-11. 2002
    ..Later on, during the cap stage, differential expression was observed; of note was the expression of MMP 3 within the enamel knot...
  69. ncbi Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis
    Giorgio Ghilardi
    Dipartimento di Medicina, Chirurgia, e Odontoiatria, Clinica Chirurgica Generale, Università degli Studi di Milano Polo S Paolo, Milan, Italy
    Stroke 33:2408-12. 2002
    ..The aim of this study was to investigate a possible association between MMP polymorphisms and increased risk of internal carotid artery (ICA) stenosis...
  70. ncbi Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells
    Y Y Li
    Research Laboratories, University of Pittsburgh School of Medicine, PA 15213, USA
    Cardiovasc Res 42:162-72. 1999
    ..Tissue inhibitors of metalloproteinases (TIMPs) are downregulated in the failing human heart. The objective of the present study was to test the hypothesis that cytokines might be involved in the regulation of TIMPs in cardiac cells...
  71. pmc Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts
    L M Matrisian
    EMBO J 4:1435-40. 1985
    ..Our results point to the existence of intracellular mechanisms that are common to the action of both growth factors and oncogenes...
  72. ncbi Structure-function relationships in the collagenase family member transin
    R Sanchez-Lopez
    Laboratoire de Genetique Moleculaire des Eucaryotes, Institut National de la Sante et de la Recherche Medicale, Faculte de Medecine, Strasbourg, France
    J Biol Chem 263:11892-9. 1988
    ....
  73. pmc Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts
    L M Matrisian
    Mol Cell Biol 6:1679-86. 1986
    ..The protein sequence encoded by the last four exons of the transin gene shows some homology to two regions of the heme-binding protein hemopexin...
  74. ncbi Purification and properties of extracellular matrix-degrading metallo-proteinase overproduced by Rous sarcoma virus-transformed rat liver cell line, and its identification as transin
    F Umenishi
    Division of Cell Biology, Kihara Institute for Biological Research, Yokohama City University, Kanagawa
    J Biochem 108:537-43. 1990
    ..Analysis of its partial amino acid sequence and amino acid composition showed that the 57k proenzyme was identical or closely related to the putative protein transin, a rat homologue of stromelysin...
  75. doi Habituation-induced neural plasticity in the hippocampus and prefrontal cortex mediated by MMP-3
    John W Wright
    Department of Psychology, Washington State University, Pullman, WA 99164 4820, United States
    Behav Brain Res 203:27-34. 2009
    ..These results suggest that elevations in hippocampus and prefrontal cortex MMP-3 expression contribute to this simplest form of learning and may be a mechanism underlying spontaneous recovery...
  76. doi Cholinoceptor modulation on nitric oxide regulates prostaglandin E(2) and metalloproteinase-3 production in experimentally induced inflammation of rat dental pulp
    Alejandra De Couto Pita
    Pharmacology Unit, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina
    J Endod 35:529-36. 2009
    ..The capacity of pilocarpine to prevent iNOS activity, PGE(2), and MMP-3 by acting on mAChR mutation induced by pulpitis might be useful therapeutically as a local treatment...
  77. pmc Keratinocyte expression of MMP3 enhances differentiation and prevents tumor establishment
    Lisa J McCawley
    Vanderbilt University, Department of Cancer Biology, Nashville, TN 37232 6840, USA
    Am J Pathol 173:1528-39. 2008
    ..We previously demonstrated that MMP3-null animals have an increased sensitivity to the development of squamous cell carcinoma, suggesting that overall, ..
  78. pmc 1,25-Dihydroxy vitamin D3 is an autocrine regulator of extracellular matrix turnover and growth factor release via ERp60-activated matrix vesicle matrix metalloproteinases
    B D Boyan
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Cells Tissues Organs 189:70-4. 2009
    ..Chondrocytes secrete 1,25(OH)(2)D(3), which acts directly on MV-membranes via ERp60, releasing MMPs. MMP-specific ECM components are hydrolyzed, resulting in release and activation of growth factors that can act back on the cells...
  79. doi Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy
    Kentaro Nishida
    Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Services, Kagoshima University, Kagoshima, Japan
    Cancer Sci 99:1618-25. 2008
    ..Taken together, the up-regulation of MMP-3 and following macrophage activation caused in the dorsal root ganglion might be a significant event to trigger a series of reactions developing paclitaxel-induced peripheral neuropathic pain...
  80. pmc Activity-dependent shedding of the NMDA receptor glycine binding site by matrix metalloproteinase 3: a PUTATIVE mechanism of postsynaptic plasticity
    Thorsten Pauly
    Department of Anatomy and Cellular Neurobiology, University of Ulm, Ulm, Germany
    PLoS ONE 3:e2681. 2008
    ..In conclusion, our data indicate that MMPs, and in particular MMP-3, are involved in the activity dependent alteration of NMDA receptor structure at postsynaptic membrane specializations in the CNS...
  81. doi Endothelins stimulate the production of stromelysin-1 in cultured rat astrocytes
    Yutaka Koyama
    Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Nishikiori Kita 3 11 1, Tonda bayashi, Osaka 584 8540, Japan
    Biochem Biophys Res Commun 371:659-63. 2008
    ..These results show that activation of astrocytic ET receptors stimulates the production of stromelysin-1, suggesting a role for ETs in stromelysin production in brain pathologies...
  82. doi Changes in gene expression of individual matrix metalloproteinases differ in response to mechanical unloading of tendon fascicles in explant culture
    Diane R Leigh
    Department of Biomedical Engineering, Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Orthop Res 26:1306-12. 2008
    ..However, changes in both MMP3 and MMP13 gene expression are rapid, dramatic, sustained, and changing during at least the first 48 h of unloaded ..
  83. ncbi [Expression of matrix metalloproteinase-3 after brain contusion in rats]
    Xiao chong Guo
    Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China
    Fa Yi Xue Za Zhi 25:1-5. 2009
    ..To investigate the expression of matrix metalloproteinase-3 after brain contusion and its applicability for estimating the age of brain contusion...
  84. ncbi Matrix metalloproteinase-3 induction in rat brain astrocytes: focus on the role of two AP-1 elements
    Kwang Soo Kim
    Department of Pharmacology and Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea 442 721
    Biochem J 410:605-11. 2008
    ....
  85. pmc Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat
    Eduardo Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    J Pharmacol Exp Ther 323:488-98. 2007
    ..Modulation of COX in brain injury by COX inhibitors or agents modulating prostaglandin E(2) formation/signaling may be useful in clinical settings associated with BBB disruption...
  86. ncbi [Identification of extracellular matrix metalloprotease 3 in the fetal membrane of the rat and its possible implication in the rupture of chorioamniotic membranes]
    Noemí Meraz Cruz
    Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Lomas de Virreyes, Mexico, DF
    Ginecol Obstet Mex 74:671-7. 2006
    ..Human corioamniotic membranes, or their equivalent in the rat, function as selective barrier during gestation and their rupture is part of the mechanisms implied in the labor. Molecular mechanisms carried out in this process are unknown...
  87. ncbi [Correlation between matrix metalloproteinases activities and myocardial injury in neonatal rats after asphyxia]
    Shu Zhen Xu
    Department of Pediatrics, Qingdao Municipal Hospital, Qingdao 266011, China
    Zhonghua Er Ke Za Zhi 45:134-7. 2007
    ..To study possible correlation between matrix metalloproteinases (MMPs) activities and myocardial injury after asphyxia in neonatal Wistar rats...
  88. ncbi Kinetics of MMP-1 and MMP-3 produced by mast cells and macrophages in liver fibrogenesis of rat
    Won Il Jeong
    Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 702 701, Republic of Korea
    Anticancer Res 26:3517-26. 2006
    ..The involvement of whether macrophages and mast cells in the kinetics of matrix metalloproteinases-1 (MMP-1), MMP-3 and MMP-9, tissue inhibitors of metalloproteinases-1 (TIMP-1) and TIMP-2 in hepatic fibrosis/cirrhosis was examined...
  89. ncbi [Effects of glutamine on matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-3 expressions in myocardium of rats with sepsis]
    Hong Wang
    Department of Pediatrics, 2nd Affiliated Hospital, China Medical University, Shenyang 110004, China
    Zhonghua Er Ke Za Zhi 44:587-91. 2006
    ..The aim of the present study was to examine the effects of Gln on the expressions of matrix metalloproteinase-3 (MMP-3), tissue inhibitor of metalloproteinase-3 (TIMP-3) and their mRNA in myocardium of rats with sepsis...
  90. ncbi Modulation of extracellular matrix components by metalloproteinases and their tissue inhibitors during degeneration and regeneration of rat sural nerve
    M A V Gantus
    Departamento de Histologia e Embriologia, Centro de Ciencias da Saude, Bloco F, Universidade Federal do Rio de Janeiro, Av Brigadeiro Trompowsky s n, 21941 540, Rio de Janeiro, Brazil
    Brain Res 1122:36-46. 2006
    ..These results indicate that the modifications of ECM components, which are favorable for nerve regeneration, are correlated with changes on the balance between MMPs and TIMPs...

Research Grants4

  1. ROLE OF MEMBRANES AND MINERALIZATION OF BONES AND TEETH
    Barbara Boyan; Fiscal Year: 2001
    ..This work will have major implications for our understanding of MV and how cells that calcify their matrix are able to regulate these extracellular organelles at distant sites. ..
  2. BONE FACTORS AND ENDOCHONDRAL OSSIFICATION
    Barbara Boyan; Fiscal Year: 2001
    ..It is suggested that these results will provide insight into the role these factors play in bone development and repair. ..
  3. Influence of Sex and Gender on Musculoskeletal Health
    Barbara Boyan; Fiscal Year: 2004
    ..Worldwide current and future clinical trials will be discussed. Short papers on the workshop topics, future directions, and scientific updates will be published via Internet and summary papers in peer-reviewed journals. ..
  4. Development of Hydrogel Spinal Disc Replacement
    Barbara Boyan; Fiscal Year: 2004
    ..abstract_text> ..