Species

Mir145

Summary

Gene Symbol: Mir145
Description: microRNA 145
Alias: rno-mir-145
Species: rat

Top Publications

  1. pmc MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation
    Yunhui Cheng
    Department of Anesthesiology, New Jersey Medical School, UMDNJ, 185 South Orange Ave, MSB E548, Newark, NJ 07101, USA
    Circ Res 105:158-66. 2009
  2. doi Identification of novel MicroRNA signatures linked to experimental autoimmune myasthenia gravis pathogenesis: down-regulated miR-145 promotes pathogenetic Th17 cell response
    Jiao Wang
    Department of Neurology, the Affiliated Hospital of Xuzhou Medical College, 99 West Huai hai Rd, Xuzhou, China, 221002
    J Neuroimmune Pharmacol 8:1287-302. 2013
  3. doi General principles and methods for routine automated microRNA in situ hybridization and double labeling with immunohistochemistry
    U Singh
    Toxicology and Pathology, Non Clinical Safety, Hoffmann La Roche Inc, Nutley, NJ
    Biotech Histochem 89:259-66. 2014
  4. pmc Flank sequences of miR-145/143 and their aberrant expression in vascular disease: mechanism and therapeutic application
    Xiaojun Liu
    Department of Pharmacology and Cardiovascular Research Center, Rush University Medical Center, Chicago, IL
    J Am Heart Assoc 2:e000407. 2013
  5. doi MicroRNA-145 as one negative regulator of astrogliosis
    Chih Yen Wang
    Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan
    Glia 63:194-205. 2015
  6. pmc Mutual induction of transcription factor PPARγ and microRNAs miR-145 and miR-329
    Ashutosh Dharap
    Department of Neurological Surgery and Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin, USA
    J Neurochem 135:139-46. 2015
  7. doi MicroRNA-145 repairs infarcted myocardium by accelerating cardiomyocyte autophagy
    Kenshi Higashi
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan and
    Am J Physiol Heart Circ Physiol 309:H1813-26. 2015
  8. ncbi [Role of miR-145 in erectile dysfunction in diabetic rats]
    An yang Wei
    Division of Urinary Surgery, Huiqiao Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1051-4. 2011
  9. pmc miR-145 is differentially regulated by TGF-β1 and ischaemia and targets Disabled-2 expression and wnt/β-catenin activity
    Maritza E Mayorga
    Skirball Laboratory for Cardiovascular Cellular Therapeutics, Cleveland, OH, USA
    J Cell Mol Med 16:1106-13. 2012
  10. doi MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKIIδ
    Min Ji Cha
    Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun gu, Seoul 120 752, Republic of Korea
    Biochem Biophys Res Commun 435:720-6. 2013

Scientific Experts

  • Xiaojun Liu
  • Yunhui Cheng
  • Chih Yen Wang
  • Kenshi Higashi
  • Ashutosh Dharap
  • U Singh
  • Min Ji Cha
  • Jiao Wang
  • Maritza E Mayorga
  • Hai Ying Zhang
  • Jian Yang
  • An yang Wei
  • Chunxiang Zhang
  • Courtney Pokrzywa
  • Shun Fen Tzeng
  • Genzou Takemura
  • Kazuhiko Nishigaki
  • Shinya Baba
  • Masanori Kawasaki
  • Shang Hsun Yang
  • Raghu Vemuganti
  • Yoshihisa Yamada
  • Shingo Minatoguchi
  • Masamitsu Iwasa
  • Shinya Minatoguchi
  • Shruthi Murali
  • Yukihiro Akao
  • Balarama Kaimal
  • Hiromitsu Kanamori
  • Minami Kumazaki
  • M Albassam
  • N Keirstead
  • R Garrido
  • M Odin
  • A Wolujczyk
  • Shanshan Qin
  • Jun Hee Park
  • Shuangshuang Zheng
  • Hyang Hee Seo
  • Yang Lu
  • Jiyun Lee
  • Jinhua Wang
  • Ning Xin
  • Xiuying Zhang
  • Changxin Dou
  • Jing Chen
  • Hyun Taek Shin
  • Eunmi Choi
  • Xiangyu Zhou
  • Ruiguo Dong
  • Onju Ham
  • Eunhyun Choi
  • Hye Jin Hwang
  • Xiaojun Tang
  • Guiyun Cui
  • Deqin Geng
  • Byeong Wook Song
  • Jin Kyung Jang
  • Linlin Fu
  • Xiuwei Chen
  • Woo Min Jeon
  • Chenghua Xiao
  • Ki Chul Hwang
  • Yuehua Qiao
  • Thomas J Krall
  • Se Yeon Lee
  • Xia Shen
  • Yanyan Zhang
  • Yong Zhang
  • Chang Yeon Lee
  • Marc S Penn
  • Dan Zhao
  • Jiu Hong Zhao
  • Lin Feng Zheng
  • Wei Zhao
  • Zhi Bin Chen
  • Xin Gui Luo
  • Yang Liu
  • Shu hua He
  • Tao Zhang
  • Su Juan Zheng
  • Xian Fang Zhang
  • Jian Ming Li
  • Xi Nan Yi
  • Yong Yang
  • Yuqing Huo
  • Ying Lin
  • Edwin A Deitch
  • Qi Lu
  • Da Zhong Xu

Detail Information

Publications11

  1. pmc MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation
    Yunhui Cheng
    Department of Anesthesiology, New Jersey Medical School, UMDNJ, 185 South Orange Ave, MSB E548, Newark, NJ 07101, USA
    Circ Res 105:158-66. 2009
    ..These novel findings may have extensive implications for the diagnosis and therapy of a variety of proliferative vascular diseases...
  2. doi Identification of novel MicroRNA signatures linked to experimental autoimmune myasthenia gravis pathogenesis: down-regulated miR-145 promotes pathogenetic Th17 cell response
    Jiao Wang
    Department of Neurology, the Affiliated Hospital of Xuzhou Medical College, 99 West Huai hai Rd, Xuzhou, China, 221002
    J Neuroimmune Pharmacol 8:1287-302. 2013
    ..Our studies provide an important new insight into the pathogenesis of EAMG and MG, which may open a new perspective for the development of effective gene therapy for EAMG/MG. ..
  3. doi General principles and methods for routine automated microRNA in situ hybridization and double labeling with immunohistochemistry
    U Singh
    Toxicology and Pathology, Non Clinical Safety, Hoffmann La Roche Inc, Nutley, NJ
    Biotech Histochem 89:259-66. 2014
    ..These methods may be used routinely for exploratory studies of biomarker development, sample screening and understanding the role of miRNA in the pathophysiology of specific diseases...
  4. pmc Flank sequences of miR-145/143 and their aberrant expression in vascular disease: mechanism and therapeutic application
    Xiaojun Liu
    Department of Pharmacology and Cardiovascular Research Center, Rush University Medical Center, Chicago, IL
    J Am Heart Assoc 2:e000407. 2013
    ..The purpose of this study was to determine the molecular mechanisms responsible for their downregulation and to overcome the therapeutic barrier...
  5. doi MicroRNA-145 as one negative regulator of astrogliosis
    Chih Yen Wang
    Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan
    Glia 63:194-205. 2015
    ..glia 2015;63:194-205...
  6. pmc Mutual induction of transcription factor PPARγ and microRNAs miR-145 and miR-329
    Ashutosh Dharap
    Department of Neurological Surgery and Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin, USA
    J Neurochem 135:139-46. 2015
    ..Two such PPARγ-responsive microRNAs (miR-145 and miR-329) bind to PPARγ promoter to induce its expression. This indicates the presence of a feedback loop by which transcription factors and microRNAs can modulate each other. ..
  7. doi MicroRNA-145 repairs infarcted myocardium by accelerating cardiomyocyte autophagy
    Kenshi Higashi
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan and
    Am J Physiol Heart Circ Physiol 309:H1813-26. 2015
    ..In conclusion, post-MI treatment with miR-145 protected the heart through the induction of cardiomyocyte autophagy by targeting fibroblast growth factor receptor substrate 2. ..
  8. ncbi [Role of miR-145 in erectile dysfunction in diabetic rats]
    An yang Wei
    Division of Urinary Surgery, Huiqiao Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1051-4. 2011
    ..To investigate the role of miR-145 in the corpus cavernosum smooth muscle tissue in the pathogenesis of erectile dysfunction (ED) in diabetic rats...
  9. pmc miR-145 is differentially regulated by TGF-β1 and ischaemia and targets Disabled-2 expression and wnt/β-catenin activity
    Maritza E Mayorga
    Skirball Laboratory for Cardiovascular Cellular Therapeutics, Cleveland, OH, USA
    J Cell Mol Med 16:1106-13. 2012
    ..Our data demonstrate a novel and critical role for miR-145 expression as a regulator of Dab2 expression and β-catenin activity in response to TGF-β(1) and hypoxia...
  10. doi MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKIIδ
    Min Ji Cha
    Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun gu, Seoul 120 752, Republic of Korea
    Biochem Biophys Res Commun 435:720-6. 2013
    ..This study demonstrates that miR-145 regulates reactive oxygen species (ROS)-induced Ca(2+) overload in cardiomyocytes. Thus, miR-145 affects ROS-mediated gene regulation and cellular injury responses...
  11. doi MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection
    Hai Ying Zhang
    Department of Anatomy, Hainan Medical College, Haikou 571101, Hainan, China
    Brain Res 1383:62-70. 2011
    ..Finding from this study suggested that miRNAs of DRG can mediated the course of regeneration including through Slit-Robo-srGAP signaling pathway after injury...