Mdk

Summary

Gene Symbol: Mdk
Description: midkine
Alias: midkine
Species: rat

Top Publications

  1. ncbi The growth factor midkine is modulated by both glucocorticoid and retinoid in fetal lung development
    Feige Kaplan
    McGill University Montreal Children s Hospital Research Institute, Department of Human Genetics, McGill University Health Centre, Montreal, Quebec, Canada
    Am J Respir Cell Mol Biol 28:33-41. 2003
  2. doi Expression of the heparin-binding growth factor midkine and its receptor, Ptprz1, in adult rat pituitary
    Ken Fujiwara
    Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke, Tochigi, 329 0498, Japan
    Cell Tissue Res 359:909-14. 2015
  3. ncbi Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: temporally distinct expression of midkine and pleiotrophin
    X Liu
    Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Glia 24:390-7. 1998
  4. doi Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration
    Daniel García-Pérez
    Group of Molecular and Cellular Pharmacology, Medical Faculty of Murcia, Campus de Espinardo, 30100 Murcia, Spain Instituto Murciano de Investigación Biosanitaria IMIB, Murcia, Spain Electronic address
    J Neuroimmunol 274:244-8. 2014
  5. ncbi Interaction between the protein kinase B-Raf and the alpha-subunit of the 11S proteasome regulator
    A Kalmes
    Institut fur Medizinische Strahlenkunde und Zellforschung, University of Wurzburg, Germany
    Cancer Res 58:2986-90. 1998
  6. ncbi alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor
    Hisako Muramatsu
    Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Cell Sci 117:5405-15. 2004
  7. doi Downregulation of Midkine gene expression and its response to retinoic acid treatment in the nitrofen-induced hypoplastic lung
    Takashi Doi
    National Children s Research Centre, Our Lady s Children s Hospital, Dublin 12, Ireland
    Pediatr Surg Int 27:199-204. 2011
  8. doi Apolipoprotein A-V modulates insulin secretion in pancreatic beta-cells through its interaction with midkine
    Audrey Helleboid-Chapman
    Universite Lille Nord de France, INSERM, UDSL and Institut Pasteur de Lille, France
    Cell Physiol Biochem 24:451-60. 2009
  9. pmc The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells
    Huayan Zhang
    Division of Neonatology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Respir Res 10:77. 2009
  10. doi Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain
    Laura Ezquerra
    Department of Molecular and Experimental Medicine and Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    Growth Factors 26:44-8. 2008

Scientific Experts

  • Daniel García-Pérez
  • Harutoshi Sakakima
  • Huayan Zhang
  • Deanna M Marchionini
  • Laura Ezquerra
  • Takashi Muramatsu
  • Ken Fujiwara
  • Hisako Muramatsu
  • Takashi Doi
  • T Muramatsu
  • Audrey Helleboid-Chapman
  • Manabu Wada
  • Thomas F Deuel
  • Luis F Alguacil
  • Gonzalo Herradon
  • Takafumi Yuki
  • Yasushi Hirota
  • Waichi Sato
  • Sadatoshi Sakuma
  • Miklós Palotás
  • Kae Kikuchi-Horie
  • Brandon K Harvey
  • Kiyoko Maruyama
  • Kiyomitsu Oyanagi
  • Feige Kaplan
  • Makiko Kamata
  • Alimuddin Tofrizal
  • Rahimi Syaidah
  • Kotaro Horiguchi
  • Takashi Yashiro
  • Dini Ramadhani
  • Motoshi Kikuchi
  • Takehiro Tsukada
  • Rita Maliza
  • Khongorzul Batchuluun
  • Morio Azuma
  • M Qi
  • S Sakuma
  • S Ikematsu
  • Mika Shintaku
  • Prem Puri
  • K Kadomatsu
  • Jens Dingemann
  • Elke Ruttenstock
  • M Horiba
  • P Dewing
  • C Ueoka
  • Stephane Helleboid
  • Emmanuelle Moitrot
  • Hervé Drobecq
  • Helene Dehondt
  • Maxime Nowak
  • Jean Charles Fruchart
  • Corinne Rommens
  • Jamila Fruchart-Najib
  • Laurent Heliot
  • Trang Nguyen
  • Inmaculada Silos-Santiago
  • Elisa Garrido
  • Carmen Díez-Fernández
  • Carmen Perez-Garcia
  • M A K Rumi
  • X Liu
  • Yuji Amano
  • Norihisa Ishimura
  • A Kalmes
  • Nobuyuki Moriyama
  • Yoshikazu Kinoshita
  • H Obama
  • Yasunori Kadowaki
  • Shunji Ishihara
  • Cesar F Ortega-Cava
  • Hideaki Kazumori
  • Yukio Yuzawa
  • Yutaka Osuga
  • Seiichi Matsuo
  • Tetsu Yano
  • Osamu Yoshino
  • Yoshifumi Takei
  • Tetsuya Hirata
  • Osamu Tsutsumi
  • Miyuki Harada
  • Chieko Morimoto
  • Kaori Koga
  • Kenji Kadomatsu
  • Yuji Taketani
  • Hachiro Nakagawa
  • Magdolna Pakaski
  • Laszlo G Puskas
  • Guo Yun Chen

Detail Information

Publications28

  1. ncbi The growth factor midkine is modulated by both glucocorticoid and retinoid in fetal lung development
    Feige Kaplan
    McGill University Montreal Children s Hospital Research Institute, Department of Human Genetics, McGill University Health Centre, Montreal, Quebec, Canada
    Am J Respir Cell Mol Biol 28:33-41. 2003
    ..cDNA microarray analysis showed organ-specific upregulation of the retinoic acid responsive gene midkine (MK) and its chondroitin-sulfate binding partner PG-M/versican at fetal day 18 and at neonatal day 1 in lungs of ..
  2. doi Expression of the heparin-binding growth factor midkine and its receptor, Ptprz1, in adult rat pituitary
    Ken Fujiwara
    Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke, Tochigi, 329 0498, Japan
    Cell Tissue Res 359:909-14. 2015
    b>Midkine (MK) belongs to a family of secreted heparin-binding growth factors and is highly expressed in various tissues during development...
  3. ncbi Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: temporally distinct expression of midkine and pleiotrophin
    X Liu
    Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Glia 24:390-7. 1998
    ..pattern and possible function in multiple sclerosis, the heparin-binding growth factors pleiotrophin (PTN), midkine (MK), basic fibroblast growth factor (FGF-2) and one of its receptors (FGFR1/flg) mRNA and protein levels were ..
  4. doi Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration
    Daniel García-Pérez
    Group of Molecular and Cellular Pharmacology, Medical Faculty of Murcia, Campus de Espinardo, 30100 Murcia, Spain Instituto Murciano de Investigación Biosanitaria IMIB, Murcia, Spain Electronic address
    J Neuroimmunol 274:244-8. 2014
    Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine ..
  5. ncbi Interaction between the protein kinase B-Raf and the alpha-subunit of the 11S proteasome regulator
    A Kalmes
    Institut fur Medizinische Strahlenkunde und Zellforschung, University of Wurzburg, Germany
    Cancer Res 58:2986-90. 1998
    ..No association could be found between PA28alpha and A-Raf or c-Raf-1. B-Raf binds to a region in PA28alpha that is important for its proteasome-activating function...
  6. ncbi alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor
    Hisako Muramatsu
    Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Cell Sci 117:5405-15. 2004
    b>Midkine is a heparin-binding growth factor that promotes the growth, survival, migration and differentiation of various target cells...
  7. doi Downregulation of Midkine gene expression and its response to retinoic acid treatment in the nitrofen-induced hypoplastic lung
    Takashi Doi
    National Children s Research Centre, Our Lady s Children s Hospital, Dublin 12, Ireland
    Pediatr Surg Int 27:199-204. 2011
    ..b>Midkine (MK), a RA-responsive growth factor, plays key roles in various organogenesis including lung development...
  8. doi Apolipoprotein A-V modulates insulin secretion in pancreatic beta-cells through its interaction with midkine
    Audrey Helleboid-Chapman
    Universite Lille Nord de France, INSERM, UDSL and Institut Pasteur de Lille, France
    Cell Physiol Biochem 24:451-60. 2009
    ..Results showed an interaction between apoA-V and midkine protein...
  9. pmc The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells
    Huayan Zhang
    Division of Neonatology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Respir Res 10:77. 2009
    ..The mechanisms controlling this balance are largely unknown, but recent evidence suggests that midkine (MK), a retinoic acid-regulated, pro-angiogenic growth factor, may function as a critical regulator...
  10. doi Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain
    Laura Ezquerra
    Department of Molecular and Experimental Medicine and Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    Growth Factors 26:44-8. 2008
    Pleiotrophin (PTN) and midkine (MK) are two growth factors highly redundant in function that exhibit neurotrophic actions and are upregulated at sites of nerve injury, both properties being compatible with a potential involvement in the ..
  11. ncbi Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease
    Deanna M Marchionini
    Dept Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Brain Res 1147:77-88. 2007
    ..b>Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were ..
  12. ncbi Morphine and yohimbine regulate midkine gene expression in the rat hippocampus
    Laura Ezquerra
    Department of Molecular and Experimental Medicine and Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    Eur J Pharmacol 557:147-50. 2007
    Pleiotrophin and midkine are two recently discovered growth factors that promote survival and differentiation of catecholaminergic neurons...
  13. ncbi Midkine and its receptor in regenerating rat skeletal muscle after bupivacaine injection
    Harutoshi Sakakima
    School of Health Sciences, Faculty of Medicine, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Acta Histochem 108:357-64. 2006
    b>Midkine (MK) is a multifunctional cytokine and heparin-binding growth factor with neurotrophic activity...
  14. ncbi Increased expression of midkine in the rat colon during healing of experimental colitis
    Takafumi Yuki
    Dept of Gastroenterology and Hepatology, Shimane Medical Univ School of Medicine, 89 1, Enya cho, Izumo, Shimane 693 0021, Japan
    Am J Physiol Gastrointest Liver Physiol 291:G735-43. 2006
    b>Midkine (MK) is a unique growth and differentiation factor that modulates the proliferation and migration of various cells; however, little is known regarding its relationship to intestinal diseases...
  15. ncbi Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion
    Waichi Sato
    Department of Clinical Immunology of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Kidney Int 67:1330-9. 2005
    b>Midkine, a heparin-binding growth factor, is involved in the migration of inflammatory cells...
  16. ncbi Possible implication of midkine in the development of endometriosis
    Yasushi Hirota
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Tokyo, 113 8655, Japan
    Hum Reprod 20:1084-9. 2005
    The present study was conducted to assess whether midkine (MK), a multifunctional molecule known to stimulate tumor growth, may be involved in the development of endometriosis.
  17. ncbi Midkine expression in rat spinal motor neurons following sciatic nerve injury
    Harutoshi Sakakima
    School of Medical Sciences, Faculty of Medicine, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima, 890 8520, Japan
    Brain Res Dev Brain Res 153:251-60. 2004
    b>Midkine (MK), a heparin-binding growth factor, is produced in the developing and damaged nervous system. However, the role of MK in peripheral nerve injury has not been clarified...
  18. ncbi Regulation and localization of midkine in rat ovary
    S Karino
    Department of Obstetrics and Gynecology, Gunma University School of Medicine, Japan
    FEBS Lett 362:147-50. 1995
    In a previous experiment, it was shown that midkine (MK) was quite abundant in the follicular fluid; the concentration of MK in bovine follicular fluid was estimated to be 125 micrograms/l...
  19. ncbi Midkine and retinoic acid reduce cerebral infarction induced by middle cerebral artery ligation in rats
    Brandon K Harvey
    Neural Protection and Regeneration Section, Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21124, USA
    Neurosci Lett 369:138-41. 2004
    The present study investigates the neuroprotective effects of midkine (MK) and retinoic acid (RA) against ischemia in the CNS...
  20. ncbi Gene expression profile analysis of the rat cortex following treatment with imipramine and citalopram
    Miklós Palotás
    Department of Psychiatry, Albert Szent Györgyi Medical and Pharmaceutical Centre, Faculty of Medicine, University of Szeged, H 6721 Szeged, Semmelweis u 6, Hungary
    Int J Neuropsychopharmacol 7:401-13. 2004
    ..g. midkine, stress-inducible protein), and determinants of membrane conductance and ion transport (e.g...
  21. ncbi Midkine, a heparin-binding growth factor, is fundamentally involved in the pathogenesis of rheumatoid arthritis
    Kiyoko Maruyama
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Arthritis Rheum 50:1420-9. 2004
    b>Midkine (MK), a heparin-binding growth factor, promotes growth, survival, and migration of various cells. The essential role of MK in migration of inflammatory cells has been shown using mice deficient in the MK gene (Mdk(-/-) mice)...
  22. ncbi Distinctive expression of midkine in the repair period of rat brain during neurogenesis: immunohistochemical and immunoelectron microscopic observations
    Kae Kikuchi-Horie
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Neurosci Res 75:678-87. 2004
    Distinctive expression of midkine (MK) was observed during the repair period of fetal brain neuroepithelium...
  23. ncbi Alteration of midkine expression in the ischemic brain of humans
    Manabu Wada
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    J Neurol Sci 200:67-73. 2002
    b>Midkine (MK) is a heparin-binding growth factor that occurs as a product of the retinoic acid-inducible gene...
  24. ncbi Haptotactic migration induced by midkine. Involvement of protein-tyrosine phosphatase zeta. Mitogen-activated protein kinase, and phosphatidylinositol 3-kinase
    M Qi
    Department of Biochemistry, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    J Biol Chem 276:15868-75. 2001
    b>Midkine, a heparin-binding growth factor, plays a critical role in cell migration causing suppression of neointima formation in midkine-deficient mice. Here we have determined the molecules essential for midkine-induced migration...
  25. ncbi Midkine is expressed early in rat fetal adrenal development
    P Dewing
    Department of Human Genetics, Los Angeles, California 90095, USA
    Mol Genet Metab 71:616-22. 2000
    ..One member of the extracellular PTN/MDK (pleiotrophin/midkine) heparin-binding protein family involved in regulation of growth and differentiation was selected for initial ..
  26. ncbi Neuronal cell adhesion, mediated by the heparin-binding neuroregulatory factor midkine, is specifically inhibited by chondroitin sulfate E. Structural ans functional implications of the over-sulfated chondroitin sulfate
    C Ueoka
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 275:37407-13. 2000
    The heparin-binding neurotrophic factor midkine (MK) has been proposed to mediate neuronal cell adhesion and neurite outgrowth promotion by interacting with cell-surface heparan sulfate...
  27. pmc Neointima formation in a restenosis model is suppressed in midkine-deficient mice
    M Horiba
    Department of Biochemistry, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    J Clin Invest 105:489-95. 2000
    ..To find a new target to suppress neointima formation, we investigated the possible role of midkine (MK), a heparin-binding growth factor with neurotrophic and chemotactic activities, in neointima formation...
  28. ncbi Myocardial infarction induces expression of midkine, a heparin-binding growth factor with reparative activity
    H Obama
    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan
    Anticancer Res 18:145-52. 1998
    We examined midkine (MK) expression in the rat heart upon experimental myocardial infarction...