Mapt

Summary

Gene Symbol: Mapt
Description: microtubule-associated protein tau
Alias: Mtapt, RNPTAU, Tau, pTau, microtubule-associated protein tau, PHF-tau, Tau microtubule-associated protein, neurofibrillary tangle protein, paired helical filament-tau
Species: rat

Top Publications

  1. pmc Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system
    M Goedert
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 89:1983-7. 1992
  2. ncbi Expression of high molecular weight tau in the central and peripheral nervous systems
    I S Georgieff
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    J Cell Sci 105:729-37. 1993
  3. ncbi Molecular motors implicated in the axonal transport of tau and alpha-synuclein
    Michelle A Utton
    Department of Neuroscience, King s College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    J Cell Sci 118:4645-54. 2005
  4. doi Tau hyperphosphorylation affects Smad 2/3 translocation
    S Baig
    Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Bristol BS16 1LE, UK
    Neuroscience 163:561-70. 2009
  5. doi Dopamine D1 receptor activation induces tau phosphorylation via cdk5 and GSK3 signaling pathways
    Manon Lebel
    Department of Chemistry Biology, Medical Biology Section, Universite du Quebec a Trois Rivieres, Trois Rivieres, QC G9A 5H7, Canada
    Neuropharmacology 57:392-402. 2009
  6. ncbi Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis
    Christian Barbato
    Istituto di Neurobiologia e Medicina Molecolare, CNR, Viale Marx 43, 00137 Rome, Italy
    Mol Cell Neurosci 24:1038-50. 2003
  7. pmc Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau
    Ying C Yang
    Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    Mol Cell Biol 26:8357-70. 2006
  8. ncbi Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17
    M Hutton
    Mayo Clinic Jacksonville, Florida 32224, USA
    Nature 393:702-5. 1998
  9. ncbi Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments
    T Maas
    Department of Neurobiology, Interdisziplinäres Zentrum für Neurowissenschaften IZN, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    J Biol Chem 275:15733-40. 2000
  10. ncbi Specific tau phosphorylation sites in hippocampus correlate with impairment of step-down inhibitory avoidance task in rats
    Yi Gang Chen
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, HUST 13 HangKong Road, Wuhan 430030, PR China
    Behav Brain Res 158:277-84. 2005

Research Grants

  1. Tangle Formation in P301L Transgenic Mice
    Michael Hutton; Fiscal Year: 2005
  2. Amyloid and tau pathology in a transgenic model
    Michael Hutton; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications112 found, 100 shown here

  1. pmc Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system
    M Goedert
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 89:1983-7. 1992
    Microtubule-associated protein tau consists in brain of a series of isoforms of 48- to 67-kDa apparent molecular mass that are encoded by mRNAs of approximately 6 kilobases (kb) and that are generated from a single gene by alternative ..
  2. ncbi Expression of high molecular weight tau in the central and peripheral nervous systems
    I S Georgieff
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    J Cell Sci 105:729-37. 1993
    Using a novel PCR approach, we have cloned a cDNA encoding the entire high molecular weight tau molecule from rat dorsal root ganglia...
  3. ncbi Molecular motors implicated in the axonal transport of tau and alpha-synuclein
    Michelle A Utton
    Department of Neuroscience, King s College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    J Cell Sci 118:4645-54. 2005
    b>Tau and alpha-synuclein are both proteins implicated in the pathology of neurodegenerative disease...
  4. doi Tau hyperphosphorylation affects Smad 2/3 translocation
    S Baig
    Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Bristol BS16 1LE, UK
    Neuroscience 163:561-70. 2009
    ..However, recent observations suggest that TGFbeta-Smad signalling is disrupted by the hyperphosphorylation of tau, the primary component of neurofibrillary tangles: phosphorylated Smad2/3 (pSmad 2/3) co-localises with ..
  5. doi Dopamine D1 receptor activation induces tau phosphorylation via cdk5 and GSK3 signaling pathways
    Manon Lebel
    Department of Chemistry Biology, Medical Biology Section, Universite du Quebec a Trois Rivieres, Trois Rivieres, QC G9A 5H7, Canada
    Neuropharmacology 57:392-402. 2009
    ..of events that links dopamine D1 receptor activation to hyperphosphorylation of the microtubule-associated protein tau, which is normally involved in microtubules stabilization...
  6. ncbi Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis
    Christian Barbato
    Istituto di Neurobiologia e Medicina Molecolare, CNR, Viale Marx 43, 00137 Rome, Italy
    Mol Cell Neurosci 24:1038-50. 2003
    ..We have investigated the expression of Che-1 in neuronal cells and we showed that Che-1 directly interacts with Tau. Tau is a microtubule-associated protein involved in the assembly and stabilization of neuronal microtubules ..
  7. pmc Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau
    Ying C Yang
    Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    Mol Cell Biol 26:8357-70. 2006
    ..Second, SGK1 indirectly depolymerized MTs through the phosphorylation of tau at Ser214. An in vitro kinase assay revealed that active SGK1 phosphorylated tau Ser214 specifically...
  8. ncbi Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17
    M Hutton
    Mayo Clinic Jacksonville, Florida 32224, USA
    Nature 393:702-5. 1998
    ..and/or glial inclusions that stain positively with antibodies raised against the microtubule-associated protein Tau, although the Tau pathology varies considerably in both its quantity (or severity) and characteristics...
  9. ncbi Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments
    T Maas
    Department of Neurobiology, Interdisziplinäres Zentrum für Neurowissenschaften IZN, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    J Biol Chem 275:15733-40. 2000
    The axonal microtubule-associated phosphoprotein tau interacts with neural plasma membrane (PM) components during neuronal development (Brandt, R., Léger, J., and Lee, G. (1995) J. Cell Biol. 131, 1327-1340)...
  10. ncbi Specific tau phosphorylation sites in hippocampus correlate with impairment of step-down inhibitory avoidance task in rats
    Yi Gang Chen
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, HUST 13 HangKong Road, Wuhan 430030, PR China
    Behav Brain Res 158:277-84. 2005
    b>Microtubule associated protein tau is abnormally phosphorylated in Alzheimer's disease (AD) and aggregates as paired helical filaments (PHFs) in neurofibrillary tangles (NFTs), which are one of the pathological signatures of AD and their ..
  11. ncbi Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
    Diane P Hanger
    MRC Centre for Neurodegeneration Research, Department of Neuroscience, King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    J Biol Chem 282:23645-54. 2007
    b>Tau in Alzheimer disease brain is highly phosphorylated and aggregated into paired helical filaments comprising characteristic neurofibrillary tangles...
  12. ncbi Association of MAPT haplotype-tagging SNPs with sporadic Parkinson's disease
    Jana Vandrovcova
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK
    Neurobiol Aging 30:1477-82. 2009
    Mutations in the tau gene (MAPT) have been found in families with frontotemporal dementia with parkinsonism linked to chromosome 17...
  13. pmc Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease
    Yanqiu Deng
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, NY 10314, USA
    Am J Pathol 175:2089-98. 2009
    ..we investigated insulin signaling, glucose transporters, protein O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain...
  14. pmc Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture
    C J Garwood
    Department of Neuroscience, King s College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London, UK
    Cell Death Dis 2:e167. 2011
    ..characterised by the age-dependent deposition of β-amyloid (Aβ) in senile plaques, intraneuronal accumulation of tau as neurofibrillary tangles, synaptic dysfunction and neuronal death...
  15. pmc Microtubule bundling by tau proteins in vivo: analysis of functional domains
    Y Kanai
    Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan
    EMBO J 11:3953-61. 1992
    b>Tau varies both in the N-terminal region (three types) and in the C-terminal repeated microtubule binding domain (two types), generating six isoforms through alternative splicing...
  16. ncbi Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner
    M Kempf
    Institute of Neurobiology, University of Heidelberg, Germany
    J Neurosci 16:5583-92. 1996
    Microtubule-associated protein tau is localized to the axon in situ and has been implicated in the development of neuronal polarity...
  17. ncbi Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations
    M Goedert
    Medical Research Council Laboratory of Molecular Biology, Cambridge, England
    J Neurochem 75:2155-62. 2000
    Coding region and intronic mutations in the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)...
  18. ncbi Interaction of Tau with Fe65 links tau to APP
    Christian Barbato
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Roma, Italy
    Neurobiol Dis 18:399-408. 2005
    The beta-amyloid precursor protein APP and the microtubule-associated protein Tau play a crucial role in the pathogenesis of Alzheimer's disease (AD). However, the possible molecular events linking these two proteins are still unknown...
  19. pmc Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration
    A M Pittman
    Reta Lila Weston Institute of Neurological Studies, University College London, London, UK
    J Med Genet 42:837-46. 2005
    The haplotype H1 of the tau gene, MAPT, is highly associated with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD).
  20. ncbi Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM)
    Anna M Canudas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Mech Ageing Dev 126:1300-4. 2005
    b>Tau is a neuronal microtubule-associated protein found predominantly on axons. Tau phosphorylation regulates both normal and pathological functions of this protein...
  21. doi Binding of Hsp90 to tau promotes a conformational change and aggregation of tau protein
    Elena Tortosa
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    J Alzheimers Dis 17:319-25. 2009
    b>Tau pathology, associated with Alzheimer's disease, is characterized by the presence of phosphorylated and aggregated tau...
  22. doi Different MAPT haplotypes are associated with Parkinson's disease and progressive supranuclear palsy
    Mario Ezquerra
    Institut Clínic de Neurociències, Hospital Clinic de Barcelona, Department of Medicine, Universitat de Barcelona, IDIBAPS, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Barcelona, Catalonia, Spain
    Neurobiol Aging 32:547.e11-6. 2011
    The H1 MAPT haplotype in the 17q21 chromosomal region has been associated with several neurodegenerative diseases...
  23. doi The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia
    Lluis Samaranch
    Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    J Alzheimers Dis 22:1065-71. 2010
    Microtubule-associated protein tau (MAPT) and apolipoprotein E (APOE) are involved in the pathogenic mechanisms of Alzheimer's disease (AD)...
  24. ncbi [Effects of estrogen on P-Tau, ChAT and nerve growth factor protein expressions in the brain tissue of rats with Alzheimer's disease]
    Yue Huagn
    Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:2408-10. 2010
    To examine the effect of estrogen on the expressions of phosphorylated Tau (P-Tau), ChAT and nerve growth factor (NGF) protein in the brain tissue of rat models of Alzheimer disease (AD).
  25. doi Relationship of adult neurogenesis with tau phosphorylation and GSK-3β activity in subventricular zone
    Xiao ping Hong
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Neurochem Res 36:288-96. 2011
    ..in Alzheimer disease (AD), the most common neurodegenerative disorder characterized with hyperphosphorylated tau and accumulation of β-amyloid (Aβ)...
  26. pmc Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain
    Yifan Lu
    The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 286:20569-81. 2011
    In the normal brain, tau protein is phosphorylated at a number of proline- and non-proline directed sites, which reduce tau microtubule binding and thus regulate microtubule dynamics...
  27. ncbi [Involvement of Cdk5/p35 and tau protein in the hippocampal mossy fiber sprouting in the PTZ kindling model]
    Fa fa Tian
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhonghua Yi Xue Za Zhi 91:1197-202. 2011
    To observe the expression of cyclin-dependent kinase 5 (Cdk5), p35, tau protein and the activity of Cdk5 in rat hippocampus during pentylenetetrazole (PTZ) kindling process and their correlation with mossy fiber sprouting (MFS) so as to ..
  28. pmc Vector-mediated expression of erythropoietin improves functional outcome after cervical spinal cord contusion injury
    S Wang
    Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, MI 48109, USA
    Gene Ther 19:907-14. 2012
    ..Microtubule-associated protein tau, phosphorylated and nonphosphorylated neurofilament protein and the synaptic proteins synaptophysin and PSD-95 were ..
  29. doi Effect of neuronal induction on NSE, Tau, and Oct4 promoter methylation in bone marrow mesenchymal stem cells
    Ping Duan
    Stem Cells Research Center, Zhengzhou University, Zhengzhou, People s Republic of China
    In Vitro Cell Dev Biol Anim 48:251-8. 2012
    ..the methylation status of the promoter regions in neuron-specific enolase (NSE), microtubule-associated protein Tau, and Oct4 genes in MSCs pre- and post-chemical induction...
  30. doi An exploratory study on STX6, MOBP, MAPT, and EIF2AK3 and late-onset Alzheimer's disease
    Qiu Yan Liu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province, China
    Neurobiol Aging 34:1519.e13-7. 2013
    ..A recent genome-wide association study reported several single-nucleotide polymorphisms at the STX6, MOBP, MAPT, and EIF2AK3 in association with PSP...
  31. pmc Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies
    Bridget E Hawkins
    Sealy Center for Vaccine Development University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 288:17042-50. 2013
    ..Here, we used antibodies to detect oligomeric and phosphorylated Tau proteins in a non-transgenic rodent model of parasagittal fluid percussion injury...
  32. pmc Microtubule-associated protein tau is essential for long-term depression in the hippocampus
    Tetsuya Kimura
    Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 35 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Philos Trans R Soc Lond B Biol Sci 369:20130144. 2014
    The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies...
  33. doi Hyperphosphorylation of tau protein in hippocampus of central insulin-resistant rats is associated with cognitive impairment
    Dantao Peng
    Department of Neurology, Beijing Hospital, Ministry of Health, Beijing, China
    Cell Physiol Biochem 32:1417-25. 2013
    ..Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Peripheral insulin resistance increases the risk for memory impairment and the development of AD...
  34. pmc Extracellular α-synuclein leads to microtubule destabilization via GSK-3β-dependent Tau phosphorylation in PC12 cells
    Magdalena Gassowska
    Department of Cellular Signalling, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
    PLoS ONE 9:e94259. 2014
    ..Novel and most interesting data showed elevated tauopathy in PD and suggested relationship between ASN and Tau protein. However, the mechanism of ASN-evoked Tau protein modification is not fully elucidated...
  35. pmc Glycogen synthase kinase-3 regulates production of amyloid-β peptides and tau phosphorylation in diabetic rat brain
    Zhong sen Qu
    Department of Neurology, The Sixth People s Hospital Affiliated Shanghai Jiao Tong University, Yi Shan Road 600, Shanghai 200233, China
    ScientificWorldJournal 2014:878123. 2014
    ..to investigate the production of amyloid-β peptides (A β) and phosphorylation of microtubule-associated protein tau in DM rats and elucidate the role of GSK-3 and Akt (protein kinase B, PKB) in these processes...
  36. pmc The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios
    Heike J Wobst
    AstraZeneca Tufts Lab for Basic and Translational Medicine, Boston, MA, USA 1 Max Delbrück Center for Molecular Medicine, Berlin, Germany
    FEBS Lett 589:77-83. 2015
    The accumulation of amyloid-beta (Aβ) and tau aggregates is a pathological hallmark of Alzheimer's disease...
  37. pmc Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase
    Haoling Qi
    From Lille University, CNRS UMR8576, F 59000 Lille, France
    J Biol Chem 291:7742-53. 2016
    b>Tau neuronal protein has a central role in neurodegeneration and is implicated in Alzheimer disease development...
  38. ncbi Genetic analysis of MAPT haplotype diversity in frontotemporal dementia
    S M Laws
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München TU München, Ismaningerstr 22, D 81675 Munchen, Germany
    Neurobiol Aging 29:1276-8. 2008
    The H1 haplotype of the tau gene, MAPT, has been linked to the sporadic tauopathies corticobasal degeneration and progressive supranuclear palsy; however, there have been inconsistent findings regarding association with frontotemporal ..
  39. doi Gene expression of estrogen receptor, progesterone receptor and microtubule-associated protein Tau in high-risk early breast cancer: a quest for molecular predictors of treatment benefit in the context of a Hellenic Cooperative Oncology Group trial
    George Pentheroudakis
    Department of Medical Oncology, Ioannina University Hospital, Ioannina, Greece
    Breast Cancer Res Treat 116:131-43. 2009
    ..We sought to study the predictive significance and correlations of transcriptional profiling of the ER, PgR and microtubule-associated protein Tau (MAP-Tau) genes in early breast cancer.
  40. ncbi [Aberrant neuronal expression of mitotic protein, tau and Bax in the rat brain after injection of Abeta(25-35) into the amygdala]
    Dao jun Hong
    National Key Laboratory of Medical Neurobiology, Shanghai Medical College of Fudan University, Shanghai, PR China
    Sheng Li Xue Bao 55:142-6. 2003
    ..Results showed that the levels of neurofibrillary tangle (NFT) related phosphorylated tau protein and apoptosis related protein Bax were increased in Abeta(25-35) injected rat brains, meanwhile the ..
  41. doi Differential impact of REM sleep deprivation on cytoskeletal proteins of brain regions involved in sleep regulation
    Jennifer Rodríguez-Vázquez
    Area de Neurociencias, Departamento de Biologia de la Reproduccion, Universidad Autonoma Metropolitana Iztapalapa, Ciudad de Mexico, Mexico
    Neuropsychobiology 65:161-7. 2012
    ..In this study, the effects of REMSD on the content of the cytoskeletal proteins MAP2 and TAU were analyzed. Adult female rats were submitted to selective REMSD by using the multiple platform technique...
  42. doi Bip enhanced the association of GSK-3β with tau during ER stress both in vivo and in vitro
    Zan Chao Liu
    Department of Pathology and Pathophysiology, Key Laboratory of Neurological Disease of National Education Ministry and Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 29:727-40. 2012
    Hyperphosphorylated tau is the major component of intracellular neurofibrillary tangles, which is positively correlated with the cognitive decline in Alzheimer's disease (AD)...
  43. pmc Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion
    Xiaomin Yin
    Jiangsu Key Laboratory of Neuroregeneration, Medical School, Nantong University, Nantong, Jiangsu, 226001, China
    J Biol Chem 287:30497-506. 2012
    b>Tau exon 10, which encodes the second microtubule-binding repeat, is regulated by alternative splicing. Its alternative splicing generates Tau isoforms with three- or four-microtubule-binding repeats, named 3R-tau and 4R-tau...
  44. pmc Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation
    Siddhartha Mondragón-Rodríguez
    Departement de Physiologie, Universite de Montreal, Montreal, Quebec H3T 1J4, Canada
    J Biol Chem 287:32040-53. 2012
    Amyloid-β and tau protein are the two most prominent factors in the pathology of Alzheimer disease. Recent studies indicate that phosphorylated tau might affect synaptic function...
  45. doi Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation
    Yan Xiong
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Neurobiol Aging 34:745-56. 2013
    The activity of protein phosphatase (PP) 2A is downregulated and promotes the hyperphosphorylation of tau in the brains of Alzheimer's disease (AD), but the mechanism for PP2A inactivation has not been elucidated...
  46. pmc Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway
    Takayoshi Tokutake
    Department of Neurology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Biol Chem 287:35222-33. 2012
    ..by the formation of senile plaques from amyloid-β (Aβ) and neurofibrillary tangles composed of phosphorylated Tau. Although there is growing evidence for the pathogenic role of soluble Aβ species in AD, the major question of how ..
  47. doi Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains
    Minjie Tian
    Department of Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, PR China
    FEBS Lett 586:3737-45. 2012
    ..significant amyloid production in our laboratory, although amyloid neurotoxicity depended on phosphorylated tau (p-tau) in recent studies...
  48. doi Early postnatal lead exposure induces tau phosphorylation in the brain of young rats
    A Rahman
    Department of Family Sciences, College for Women, Kuwait University, Kuwait
    Acta Biol Hung 63:411-25. 2012
    Cognitive impairment is a common feature of both lead exposure and hyperphosphorylation of tau. We, therefore, investigated whether lead exposure would induce tau hyperphosphorylation. Wistar rat pups were exposed to 0...
  49. pmc Physiological release of endogenous tau is stimulated by neuronal activity
    Amy M Pooler
    Department of Neuroscience PO37, King s College London, Institute of Psychiatry, London SE5 8AF, UK
    EMBO Rep 14:389-94. 2013
    Propagation of tau pathology is linked with progressive neurodegeneration, but the mechanism underlying trans-synaptic spread of tau is unknown...
  50. ncbi Developmentally regulated expression of specific tau sequences
    K S Kosik
    Department of Neurology Neuroscience, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Neuron 2:1389-97. 1989
    b>Tau protein undergoes a shift in its molecular mass and its electrophoretic complexity during early postnatal development. We have sequenced a tau cDNA from an adult rat brain expression library and have found two inserted sequences...
  51. ncbi Diversity of high-molecular-weight tau proteins in different regions of the nervous system
    C Mavilia
    INSERM U282 associée au CNRS, Hopital Henri Mondor, Creteil, France
    J Neurochem 63:2300-6. 1994
    We show in this work that high-molecular-weight (HMW) tau transcripts are present in all the regions of the CNS and PNS studied, i.e., the dorsal root ganglia (DRG), spinal cord, cerebellum, and forebrain...
  52. ncbi Complete sequence of 3'-untranslated region of Tau from rat central nervous system. Implications for mRNA heterogeneity
    E Sadot
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    J Mol Biol 241:325-31. 1994
    b>Tau is a family of microtubule associated proteins, heterogeneous in molecular weights, which are expressed specifically in neurons...
  53. ncbi Identification of a tau promoter region mediating tissue-specific-regulated expression in PC12 cells
    E Sadot
    Department of Neurobiology The Weizmann Institute of Science, Rehovot, Israel
    J Mol Biol 256:805-12. 1996
    b>Tau, a microtubule-associated protein, is encoded by a single gene, the expression of which is neuron-specific and developmentally regulated...
  54. ncbi AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis
    G Page
    Institute of Genetics, University of Bonn, Roemerstr 164, D 53117, Bonn, Germany
    FEBS Lett 462:187-91. 1999
    ..Indeed, a Gal4-BD-AATF fusion protein exhibited strong transactivation activity. Interestingly, AATF interfered with Dlk-induced apoptosis...
  55. ncbi The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons
    Michelle A Utton
    Department of Neuroscience, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    J Neurosci 22:6394-400. 2002
    We demonstrate that the microtubule-associated protein tau, in the form of enhanced green fluorescent protein (EGFP) tau, is transported along axons of neurons in culture in the slow component of axonal transport with a speed comparable ..
  56. ncbi Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies
    Victoria Makrides
    Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    J Biol Chem 278:33298-304. 2003
    The accumulation of abnormal tau filaments is a pathological hallmark of many neurodegenerative diseases...
  57. ncbi Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Brain Res 1022:30-8. 2004
    ..Here we show that after a transient cerebral ischemia, hyperphosphorylated tau accumulates in cortical neurons in a site-specific manner...
  58. ncbi Linking alterations in tau phosphorylation and cleavage during neuronal apoptosis
    Armelle Rametti
    EA 3842, Homéostasie Cellulaire et Pathologie, Department of Histology and Cell Biology, Faculty of Medicine, Limoges 87025, France
    J Biol Chem 279:54518-28. 2004
    ..NFTs are bundles of abnormally phosphorylated tau, the paired helical filaments. The initiating mechanisms of NFTs and their role in neuronal loss are still unknown...
  59. ncbi Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis
    Anja Schneider
    Department of Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    J Biol Chem 279:55833-9. 2004
    ..Hyperphosphorylation and pathological aggregation of microtubule-associated protein tau is a common feature of many neurodegenerative diseases with axonal degeneration including Alzheimer's disease...
  60. ncbi The effect of cdk-5 overexpression on tau phosphorylation and spatial memory of rat
    Xiaomei Liao
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Sci China C Life Sci 47:251-7. 2004
    In Alzheimer's disease (AD), hyperphosphorylation of tau may be the underlying mechanism for the cytoskeletal abnormalities and neuronal death...
  61. ncbi Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau
    Deguang Zhu
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Biol Chem 279:54983-6. 2004
    ..PP2A dephosphorylates multiple substrates including tau, a microtubule-associated protein that is hyperphosphorylated in neurofibrillary tangles...
  62. ncbi Interaction of microtubule-associated protein-2 and p63: a new link between microtubules and rough endoplasmic reticulum membranes in neurons
    Carole Abi Farah
    Departement de pathologie et biologie cellulaire, Universite de Montreal, CP 6128, Succ Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 280:9439-49. 2005
    ..assay, MAP2-containing microtubules were observed to bind to RER membranes in contrast to microtubules containing tau, the axonal MAP. This binding of MAP2c microtubules was reduced when an anti-p63 antibody was added to the assay...
  63. ncbi Apoptotic effect of caspase-3 cleaved tau in hippocampal neurons and its potentiation by tau FTDP-mutation N279K
    Luisa Fasulo
    Laboratory Molecular Neurobiology LMN, International School for Advanced Studies S I S S A, Area Science Park, Padriciano 99, 34013 Trieste, Italy
    J Alzheimers Dis 7:3-13. 2005
    Pathological changes in the microtubule associated protein tau are a major hallmark of many human dementias collectively defined as tauopathies...
  64. ncbi Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons
    Sachin Patil
    Cellular and Biomolecular Laboratory, Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA
    Neurosci Lett 384:288-93. 2005
    ..The present study examines the role of fatty acids in causing hyperphosphorylation of the tau protein, one of the characteristic signatures of AD pathology...
  65. ncbi Correlation of Alzheimer-like tau hyperphosphorylation and fMRI bold intensity
    Wang Xiao-Chuan
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China
    Curr Alzheimer Res 1:143-8. 2004
    ..functional alterations revealed by functional magnetic resonance imaging (fMRI) and Alzheimer disease- (AD)-like tau hyperphosphorylation, we injected bilaterally 2 microl each of 20 mM isoproterenol (IP), a PKA activator, or of ..
  66. pmc Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat
    Ronald L Klein
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Neurobiol Dis 20:64-73. 2005
    Using a viral vector for mutant (P301L) tau, we studied the effects of gene transfer to the rat substantia nigra in terms of structural and functional properties of dopaminergic neurons...
  67. ncbi The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells
    Giuseppe Esposito
    Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Mol Med (Berl) 84:253-8. 2006
    ..Here, we report that cannabidiol inhibits hyperphosphorylation of tau protein in Abeta-stimulated PC12 neuronal cells, which is one of the most representative hallmarks in AD...
  68. ncbi The spice sage and its active ingredient rosmarinic acid protect PC12 cells from amyloid-beta peptide-induced neurotoxicity
    Teresa Iuvone
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Pharmacol Exp Ther 317:1143-9. 2006
    ..These include reactive oxygen species formation, lipid peroxidation, DNA fragmentation, caspase-3 activation, and tau protein hyperphosphorylation...
  69. ncbi Tau protects microtubules in the axon from severing by katanin
    Liang Qiang
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 26:3120-9. 2006
    ..We have hypothesized that this is because of the presence of tau on axonal microtubules...
  70. ncbi ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures
    Young Hae Chong
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, Yangcheonku, Seoul, 158 710, Korea
    J Biol Chem 281:20315-25. 2006
    ..Notably, this resulted in caspase-3 activation by a process that led to proteolytic cleavage of Tau, which was recently confirmed to occur in AD brains...
  71. ncbi Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo
    Norbert Zilka
    Axon Neuroscience GmbH, Rennweg 95B, 1030 Vienna, Austria
    FEBS Lett 580:3582-8. 2006
    Truncated tau protein is the characteristic feature of human sporadic Alzheimer's disease. We have identified truncated tau proteins conformationally different from normal healthy tau...
  72. ncbi Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms
    Yong Jie Zhang
    Pathophysiology Department, Key Laboratory of Neurological Disease of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    FASEB J 20:1431-42. 2006
    To investigate the upstream effector that led to tau hyperphosphorylation, nitration, and accumulation as seen in Alzheimer's disease brain, and the underlying mechanisms, we bilaterally injected SIN-1, a recognized peroxynitrite donor, ..
  73. ncbi Tau associates with actin in differentiating PC12 cells
    Jiang Zhou Yu
    Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, 835 S Wolcott Ave M C 901, Chicago, Illinois 60612 7342, USA
    FASEB J 20:1452-61. 2006
    The microtubule-associated protein tau may be involved in cell morphogenesis and axonal maintenance. In addition to microtubules, tau has been shown to interact with actin in vitro...
  74. ncbi Calpain- and caspase-mediated alphaII-spectrin and tau proteolysis in rat cerebrocortical neuronal cultures after ecstasy or methamphetamine exposure
    Matthew W Warren
    Center for Traumatic Brain Injury Studies, Department of Neuroscience, McKnight Brain Institute of the University of Florida, Gainesville, FL, USA
    Int J Neuropsychopharmacol 10:479-89. 2007
    ..Immunoblot analysis using biomarkers of cell death showed significant proteolysis of both alphaII-spectrin and tau proteins...
  75. ncbi Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus
    Chang E Zhang
    Department of Pathology and Pathophysiology, Hubei Provincial Key Laboratory of Neurological Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Neurobiol Aging 29:1654-65. 2008
    ..Here, we found that high plasma homocysteine induced by vena caudalis injection for 2 weeks could induce AD-like tau hyperphosphorylation at multiple sites in rat brain hippocampus...
  76. ncbi Homocysteine induces tau hyperphosphorylation in rats
    Yougen Luo
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Neuroreport 18:2005-8. 2007
    ..To investigate the effect of Hcy on phosphorylation of tau, we injected Hcy into the lateral cerebral ventricle of rats...
  77. doi Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons
    Xiaochun Chen
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China
    Brain Res 1200:99-106. 2008
    Increasing evidence have shown that beta-amyloid (Abeta) induced hyperphosphorylation of tau, which eventually resulted in the disruption of microtubule (MT) integrity...
  78. doi Lithium down-regulates tau in cultured cortical neurons: a possible mechanism of neuroprotection
    A Rametti
    Unite de Neurobiologie Cellulaire, EA 3842, Homéostasie Cellulaire et Pathologies, Faculte de Medecine, Universite de Limoges, 87025 Limoges, France
    Neurosci Lett 434:93-8. 2008
    In tauopathies such as Alzheimer's disease (AD), the moleccular mechanisms of tau protein agregation into neurofibrillary tangles (NFTs) and their contribution to neurodegeneration are not fully understood...
  79. doi Proteasome inhibition increases tau accumulation independent of phosphorylation
    Ying Hua Liu
    Department of Pathophysiology, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Neurobiol Aging 30:1949-61. 2009
    An intrinsic link between proteasome and tau degradation in Alzheimer's disease (AD) has been suggested, however, the role of proteasome in the proteolysis of tau is still uncertain...
  80. doi Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2
    Thomas Timm
    Max Planck Unit for Structural Molecular Biology, Notkestrasse 85, 22607 Hamburg, Germany
    J Biol Chem 283:18873-82. 2008
    ..Because of its role in abnormal phosphorylation of the Tau protein in Alzheimer disease, we searched for regulatory kinases...
  81. pmc Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation
    Adam R Cole
    Neurosciences Institute, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK
    J Biol Chem 283:18227-37. 2008
    ..Similar sequences in Tau are also highly resistant to phosphatase treatment...
  82. doi Age-dependent changes in neuronal distribution of CacyBP/SIP: comparison to tubulin and the tau protein
    Anna Filipek
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    J Neural Transm (Vienna) 115:1257-64. 2008
    ..neurons and in brain neurons of young and aged rats, and compared this localization with that of tubulin and the tau protein...
  83. doi Memantine protects rat cortical cultured neurons against beta-amyloid-induced toxicity by attenuating tau phosphorylation
    M S Song
    Department of Medicine, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada
    Eur J Neurosci 28:1989-2002. 2008
    ..We subsequently demonstrated that Abeta toxicity is induced by increased phosphorylation of tau protein and activation of tau kinases, i.e...
  84. pmc PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models
    Ronald L Klein
    Department of Pharmacology, LSUHSC, Shreveport, LA 71130, USA
    Brain Res 1259:113-22. 2009
    ..6-hydroxydopamine (6-OHDA) lesioning and the other was direct gene transfer of the microtubule-associated protein tau to the substantia nigra using an adeno-associated virus vector (AAV9)...
  85. pmc Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway
    Tsuyoshi Morita
    Department of Neuroscience, Osaka University Graduate School of Medicine, Yamadaoka 2 2, Suita, Osaka 565 0871, Japan
    J Biol Chem 284:27734-45. 2009
    ..pathway of mTOR-dependent axon specification, in which the collapsing response mediator protein 2 (CRMP2) and Tau are major downstream targets...
  86. pmc Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry
    Zihao Wang
    Department of Biological Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Proteomics 9:153-60. 2010
    ..Using this strategy, eight O-GlcNAc sites were mapped from a tau-enriched sample from rat brain...
  87. doi Amyloid and Tau accumulate in the brains of aged hydrocephalic rats
    Gerald D Silverberg
    Department of Clinical Neuroscience, Rhode Island Hospital and the Warren Alpert Medical School, Brown University, Providence, RI, USA
    Brain Res 1317:286-96. 2010
    ..In an aged animal model of NPH, we quantify Abeta and pTau accumulation and describe its temporal and spatial distribution...
  88. doi SSeCKS promote beta-amyloid-induced PC12 cells neurotoxicity by up-regulating tau phosphorylation in Alzheimer's disease
    Zhiming Cui
    Department of Osteology, The Second Affiliated Hospital of Nantong University, Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, People s Republic of China
    Mol Cell Biochem 340:257-63. 2010
    In Alzheimer's disease, beta-amyloid peptide (Abeta) could induce tau hyperphosphorylation which is the major cause of neuron apoptosis. However, the underlying mechanisms in the process remain unclear...
  89. pmc CSF phospho-tau correlates with behavioural decline and brain insoluble phospho-tau levels in a rat model of tauopathy
    Norbert Zilka
    Institute of Neuroimmunology, Centre of Excellence for Alzheimer s Disease and Related Disorders, Slovak Academy of Sciences, Dubravska 9, 84510 Bratislava, Slovak Republic
    Acta Neuropathol 119:679-87. 2010
    ..aim of the present study was to identify the relationship between progressive neurobehavioural decline and phospho-tau levels (p-tau(181)) in the cerebrospinal fluid (CSF) and the brain in transgenic rats expressing human truncated ..
  90. doi Diabetes synergistically exacerbates poststroke dementia and tau abnormality in brain
    Ting Zhang
    Department of Neurobiology, Institute of Biomedical Sciences, State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Rd, Shanghai 200032, PR China
    Neurochem Int 56:955-61. 2010
    This study investigated whether exacerbation of poststroke dementia by diabetes associated abnormal tau phosphorylation and its mechanism...
  91. doi Expression of the embryonal isoform (0N/3R) of the microtubule-associated protein tau in the adult rat central nervous system
    Torsten Bullmann
    Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, 04109 Leipzig, Germany
    J Comp Neurol 518:2538-53. 2010
    b>Tau is a microtubule-associated protein expressed predominantly in neurons. The transcript of the tau gene is alternatively spliced. Resulting isoforms contain three or four microtubule-binding repeats...
  92. pmc Blockade of NR2A-containing NMDA receptors induces Tau phosphorylation in rat hippocampal slices
    Julie Allyson
    Departement de Chimie Biologie, Universite du Quebec a Trois Rivieres, Trois Rivieres, QC, Canada
    Neural Plast 2010:340168. 2010
    ..of NR2A and NR2B subunits in the modulatory effect of basal NMDA receptor activity on the phosphorylation of Tau proteins...
  93. doi Chronic restraint stress alters the expression and distribution of phosphorylated tau and MAP2 in cortex and hippocampus of rat brain
    Jie Yan
    State Key Laboratory of Medical Neurobiology and Department of Neurobiology, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, PR China
    Brain Res 1347:132-41. 2010
    ..the effects of the emotional stressor, chronic restraint stress, on the expression levels and localization of tau and MAP2...
  94. doi Compression alters kinase and phosphatase activity and tau and MAP2 phosphorylation transiently while inducing the fast adaptive dendritic remodeling of underlying cortical neurons
    Li Jin Chen
    Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Neurotrauma 27:1657-69. 2010
    ..proteins (MAPs) at sites known to destabilize microtubules, including MAP2 from 30 min to 1 h, and tau from 10 min to 12 h following compression...
  95. pmc A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation
    Ya Li Zheng
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:34202-12. 2010
    ..a p10 N-terminal domain induces deregulated Cdk5 hyperactivity and perikaryal aggregations of hyperphosphorylated Tau and neurofilaments, pathogenic hallmarks in neurodegenerative diseases, such as Alzheimer disease and amyotrophic ..
  96. doi Increased expression of three-repeat isoforms of tau contributes to tau pathology in a rat model of chronic type 2 diabetes
    Hyun Jung Jung
    Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon 420 767, Korea
    Exp Neurol 228:232-41. 2011
    The imbalance between three-repeat (3R) and four-repeat (4R) tau isoforms produced by the alternative splicing of tau exon 10 leads to neuronal instability and eventual neurodegeneration in tauopathy...
  97. pmc Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation
    Jack Reifert
    Neuroscience Research Institute and Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    J Biol Chem 286:20797-811. 2011
    A variety of genetic and biochemical evidence suggests that amyloid β (Aβ) oligomers promote downstream errors in Tau action, in turn inducing neuronal dysfunction and cell death in Alzheimer and related dementias...
  98. doi Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits
    Ioannis Sotiropoulos
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 31:7840-7. 2011
    ..cognitive deficits in AD correlates strongly with levels of hyperphosphorylated forms of the cytoskeletal protein TAU, an essential mediator of the actions of amyloid β (Aβ), another molecule with a key pathogenic role in AD...
  99. doi Short- and long-term treatment with estradiol or progesterone modifies the expression of GFAP, MAP2 and Tau in prefrontal cortex and hippocampus
    Ignacio Camacho-Arroyo
    Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Coyoacan, Mexico
    Life Sci 89:123-8. 2011
    We analyzed the effects of the short- and long-term administration of estradiol (E2) or progesterone (P4) after ovariectomy on the expression of MAP2, Tau and GFAP in prefrontal cortex and hippocampus.
  100. pmc Decreases in valosin-containing protein result in increased levels of tau phosphorylated at Ser262/356
    Philip J Dolan
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA
    FEBS Lett 585:3424-9. 2011
    ..and frontotemporal dementia (IBMPFD) led us to examine the possible linkage of VCP to the AD-relevant protein, tau. VCP levels were reduced in AD brains, but not in the cerebral cortex of an AD mouse model, suggesting that VCP ..
  101. pmc Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA
    Y Kanai
    Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan
    J Cell Biol 109:1173-84. 1989
    b>Tau proteins are a class of low molecular mass microtubule-associated proteins that are specifically expressed in the nervous system. A cDNA clone of adult rat tau was isolated and sequenced...

Research Grants2

  1. Tangle Formation in P301L Transgenic Mice
    Michael Hutton; Fiscal Year: 2005
    b>Tau pathology is a key feature in numerous neurodegenerative disease including Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal dementia and parkinsonism linked to chromosome 17...
  2. Amyloid and tau pathology in a transgenic model
    Michael Hutton; Fiscal Year: 2006
    We recently developed a transgenic mouse model of neurofibrillary tangle formation by expressing mutant tau (P301L)...