Mapk1

Summary

Gene Symbol: Mapk1
Description: mitogen activated protein kinase 1
Alias: ERK-2, ERT1, Erk2, p42-MAPK, mitogen-activated protein kinase 1, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAPK 1, MAPK 2, extracellular-signal-regulated kinase 2, mitogen-activated protein kinase 2
Species: rat

Top Publications

  1. ncbi ERK 1/2 signaling pathway is involved in nicotine-mediated neuroprotection in spinal cord neurons
    Michal Toborek
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    J Cell Biochem 100:279-92. 2007
  2. doi SOCS-1 inhibits TNF-alpha-induced cardiomyocyte apoptosis via ERK1/2 pathway activation
    Ling Yan
    Department of Cardiology, Renmin Hospital of Wuhan University School of Medicine, 238 Jiefang Road, Wuchang, Wuhan 430060, People s Republic of China
    Inflammation 31:180-8. 2008
  3. ncbi 1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase
    Z Schwartz
    Department of Orthopedics, University of Texas Health Science Center, San Antonio 78229, USA
    Endocrinology 143:2775-86. 2002
  4. ncbi Role of megakaryoblastic acute leukemia-1 in ERK1/2-dependent stimulation of serum response factor-driven transcription by BDNF or increased synaptic activity
    Katarzyna Kalita
    Kentucky Spinal Cord Injury Research Center and Department of Neurological Surgery, University of Louisville, Louisville, Kentucky 40292, USA
    J Neurosci 26:10020-32. 2006
  5. pmc Selective inhibition of mitogen-activated protein kinase phosphatases by zinc accounts for extracellular signal-regulated kinase 1/2-dependent oxidative neuronal cell death
    Yeung Ho
    Department of Neuroscience, University of Pittsburgh School of Medicine, 7041 BST 3, 3501 Fifth Ave, Pittsburgh, PA 15261, USA
    Mol Pharmacol 74:1141-51. 2008
  6. doi IL-17 stimulates migration of carotid artery vascular smooth muscle cells in an MMP-9 dependent manner via p38 MAPK and ERK1/2-dependent NF-kappaB and AP-1 activation
    Gao Cheng
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Cell Mol Neurobiol 29:1161-8. 2009
  7. ncbi Phosphatidylinositol 3-kinase and ERK1/2 are not involved in adenosine A1, A2A or A3 receptor-mediated preconditioning in rat ventricle strips
    Laura Button
    School of Biomedical and Natural Sciences, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK
    Exp Physiol 90:747-54. 2005
  8. pmc Axonal outgrowth is associated with increased ERK 1/2 activation but decreased caspase 3 linked cell death in Schwann cells after immediate nerve repair in rats
    Yoshifumi Tsuda
    Department of Orthopedic Surgery, National Defense Medical College, Saitama, Japan
    BMC Neurosci 12:12. 2011
  9. ncbi Acetaminophen recruits spinal p42/p44 MAPKs and GH/IGF-1 receptors to produce analgesia via the serotonergic system
    Jérôme Bonnefont
    INSERM U766 Pharmacologie Fondamentale et Clinique de la Douleur, Facultes de Medecine et de Pharmacie, 28 Place Henri Dunant, 63001 Clermont Ferrand, France
    Mol Pharmacol 71:407-15. 2007
  10. pmc The luteinizing hormone receptor-activated extracellularly regulated kinase-1/2 cascade stimulates epiregulin release from granulosa cells
    Nebojsa Andric
    Department of Pharmacology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 149:5549-56. 2008

Research Grants

  1. GLU6PASE AND 6P2K/FBASE GENE REGULATION IN SEPSIS
    SUBIR MAITRA; Fiscal Year: 2001
  2. Identification of a new protein that binds Src and PKC
    STEPHEN SOLTOFF; Fiscal Year: 2004
  3. Neural regulation of effort in goal-directed behaviors
    Jeremy Day; Fiscal Year: 2008
  4. Cellular Regulation of Angiotensin Converting Enzyme 2 (ACE2)
    Patricia Gallagher; Fiscal Year: 2009
  5. Tat-mediated brain endothelial cell dysfunction
    Michal Toborek; Fiscal Year: 2009
  6. The function of RhoBTB proteins
    STEPHEN PAUL SOLTOFF; Fiscal Year: 2010

Detail Information

Publications183 found, 100 shown here

  1. ncbi ERK 1/2 signaling pathway is involved in nicotine-mediated neuroprotection in spinal cord neurons
    Michal Toborek
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    J Cell Biochem 100:279-92. 2007
    ..Results of the present study indicate that the ERK1/2 pathway is involved in anti-apoptotic effects of nicotine in spinal cord neurons and may be involved in therapeutic effects of nicotine in spinal cord trauma...
  2. doi SOCS-1 inhibits TNF-alpha-induced cardiomyocyte apoptosis via ERK1/2 pathway activation
    Ling Yan
    Department of Cardiology, Renmin Hospital of Wuhan University School of Medicine, 238 Jiefang Road, Wuchang, Wuhan 430060, People s Republic of China
    Inflammation 31:180-8. 2008
    ..These findings suggest that SOCS-1 prevents TNF-alpha-induced apoptosis in cardiac myocytes via ERK1/2 pathway activation...
  3. ncbi 1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase
    Z Schwartz
    Department of Orthopedics, University of Texas Health Science Center, San Antonio 78229, USA
    Endocrinology 143:2775-86. 2002
    ..The cell specificity, metabolite stereospecificity, and the dependence on PKC argue for the participation of membrane receptors for 1alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) in the regulation of ERK1/2 in the growth plate...
  4. ncbi Role of megakaryoblastic acute leukemia-1 in ERK1/2-dependent stimulation of serum response factor-driven transcription by BDNF or increased synaptic activity
    Katarzyna Kalita
    Kentucky Spinal Cord Injury Research Center and Department of Neurological Surgery, University of Louisville, Louisville, Kentucky 40292, USA
    J Neurosci 26:10020-32. 2006
    ..In addition, MKL1 appears as a novel mediator of the signaling between ERK1/2 and SRF. Moreover, MKL1 is a likely regulator of SRF-driven transcription programs that underlie neuronal plasticity...
  5. pmc Selective inhibition of mitogen-activated protein kinase phosphatases by zinc accounts for extracellular signal-regulated kinase 1/2-dependent oxidative neuronal cell death
    Yeung Ho
    Department of Neuroscience, University of Pittsburgh School of Medicine, 7041 BST 3, 3501 Fifth Ave, Pittsburgh, PA 15261, USA
    Mol Pharmacol 74:1141-51. 2008
    ..Thus, the elevation of intracellular zinc within neurons subjected to oxidative stress can trigger a robust positive feedback loop operating through activated ERK1/2 that rapidly sets into motion a zinc-dependent pathway of cell death...
  6. doi IL-17 stimulates migration of carotid artery vascular smooth muscle cells in an MMP-9 dependent manner via p38 MAPK and ERK1/2-dependent NF-kappaB and AP-1 activation
    Gao Cheng
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Cell Mol Neurobiol 29:1161-8. 2009
    ..The present results demonstrated that IL-17 may play a role in vascular remodeling and targeting IL-17 or its specific downstream mediators is a potentially novel therapeutic pathway for attenuating the post-angioplastic restenosis...
  7. ncbi Phosphatidylinositol 3-kinase and ERK1/2 are not involved in adenosine A1, A2A or A3 receptor-mediated preconditioning in rat ventricle strips
    Laura Button
    School of Biomedical and Natural Sciences, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK
    Exp Physiol 90:747-54. 2005
    ..In contrast ERK1/2 and PI3-kinase-dependent pathways do appear to be involved in early hypoxic preconditioning...
  8. pmc Axonal outgrowth is associated with increased ERK 1/2 activation but decreased caspase 3 linked cell death in Schwann cells after immediate nerve repair in rats
    Yoshifumi Tsuda
    Department of Orthopedic Surgery, National Defense Medical College, Saitama, Japan
    BMC Neurosci 12:12. 2011
    ..In the present study, axonal outgrowth, activation of ERK1/2 by phosphorylation (p-ERK 1/2 ) and immunoreactivity of cleaved caspase 3 were examined after immediate, delayed, or no repair of transected rat sciatic nerves...
  9. ncbi Acetaminophen recruits spinal p42/p44 MAPKs and GH/IGF-1 receptors to produce analgesia via the serotonergic system
    Jérôme Bonnefont
    INSERM U766 Pharmacologie Fondamentale et Clinique de la Douleur, Facultes de Medecine et de Pharmacie, 28 Place Henri Dunant, 63001 Clermont Ferrand, France
    Mol Pharmacol 71:407-15. 2007
    ....
  10. pmc The luteinizing hormone receptor-activated extracellularly regulated kinase-1/2 cascade stimulates epiregulin release from granulosa cells
    Nebojsa Andric
    Department of Pharmacology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 149:5549-56. 2008
    ..These results show that the LHR-stimulated ERK1/2 pathway stimulates epiregulin release...
  11. pmc Mitogen-activated protein kinases mediate upregulation of hypothalamic angiotensin II type 1 receptors in heart failure rats
    Shun Guang Wei
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Hypertension 52:679-86. 2008
    ..These data indicate that MAPK plays an important role in the upregulation of AT(1)-R in the rat forebrain in HF and suggest that Ang II upregulates its own receptor by this mechanism...
  12. pmc Transforming growth factor-β1 induces matrix metalloproteinase-9 and cell migration in astrocytes: roles of ROS-dependent ERK- and JNK-NF-κB pathways
    Hsi Lung Hsieh
    Department of Nursing, Division of Basic Medical Sciences, Chang Gung Institute of Technology, Tao Yuan, Taiwan
    J Neuroinflammation 7:88. 2010
    ..Both TGF-β and MMPs have been shown to play crucial roles in brain pathological changes. Thus, we investigated the molecular mechanisms underlying TGF-β1-induced MMP-9 expression in brain astrocytes...
  13. doi A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis
    Yuko Komiya
    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Yamazaki 2641, Noda shi, Chiba 278 8510, Japan
    J Biol Chem 283:18753-64. 2008
    ..These results indicate that FBI1 promotes sustained ERK1/2 activation through repression of MKP-1 transcription, resulting in promotion of tumorigenicity and metastasis...
  14. pmc ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation
    H Gille
    Max Planck Institut fur Immunbiologie, Spemann Laboratories, Freiburg, Germany
    EMBO J 14:951-62. 1995
    ..closely related to p62TCF in function, is a nuclear target of two members of the MAP kinase family, ERK1 and ERK2. Phosphorylation of Elk-1 increases the yield of ternary complex in vitro...
  15. ncbi Atomic structure of the MAP kinase ERK2 at 2.3 A resolution
    F Zhang
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas
    Nature 367:704-11. 1994
    The structure of the MAP kinase ERK2, a ubiquitous protein kinase target for regulation by Ras and Raf, has been solved in its unphosphorylated low-activity conformation to a resolution of 2.3 A...
  16. ncbi ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures
    Young Hae Chong
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, Yangcheonku, Seoul, 158 710, Korea
    J Biol Chem 281:20315-25. 2006
    ....
  17. doi Phosphorylation of phosphatidylinositol-3-kinase-protein kinase B and extracellular signal-regulated kinases 1/2 mediate reoxygenation-induced cardioprotection during hypoxia
    Giuseppina Milano
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Exp Biol Med (Maywood) 235:401-10. 2010
    ..Selective inhibition of Akt and ERK1/2 phosphorylation abolishes the beneficial effects of the reoxygenation. Therefore, Akt and ERK1/2 have an important role to mediate cardioprotection by reoxygenation during CH in vivo...
  18. ncbi p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
    D E Richard
    Institute of Signaling, Developmental Biology and Cancer Research, UMR CNRS 6543, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    J Biol Chem 274:32631-7. 1999
    ..This interaction between HIF-1alpha and p42/p44 MAPK suggests a cooperation between hypoxic and growth factor signals that ultimately leads to the increase in HIF-1-mediated gene expression...
  19. ncbi Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart
    Olli Tenhunen
    Department of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, P O Box 5000, FIN 90014 University of Oulu, Finland
    J Biol Chem 279:24852-60. 2004
    ..In conclusion, the present study demonstrates that both p38 and extracellular signal-regulated protein kinase are required for the stretch-induced GATA-4 binding in intact heart...
  20. ncbi Differential pathways of angiotensin II-induced extracellularly regulated kinase 1/2 phosphorylation in specific cell types: role of heparin-binding epidermal growth factor
    Bukhtiar H Shah
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, Building 49, Room 6A36, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    Mol Endocrinol 18:2035-48. 2004
    ..These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of MMP-dependent HB-EGF release...
  21. ncbi Reactive oxygen species mediate Endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells
    Grace Bou Daou
    Research Center, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Department of Medicine and Physiology, Universite de Montreal, Quebec, Canada
    Free Radic Biol Med 37:208-15. 2004
    ..These results demonstrate that ROS are critical mediators of ET-1-induced signaling events linked to growth-promoting proliferative and hypertrophic pathways in VSMCs...
  22. pmc Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvement
    Sophia T Papadeas
    Neurobiology Curriculum, Department of Psychiatry and University of North Carolina Neuroscience Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    J Neurosci 24:5863-76. 2004
    ..Ultimately, long-lasting phosphorylation of ERK and CREB in MPC may play a pivotal role in any permanent adaptive change(s) in these animals...
  23. ncbi Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase 1/2 activation in rat C6 glioma cells
    Seung Ju Yang
    Department of Biomedical Laboratory Science, College of Health Science, Wonju College of Medicine, Yonsei University, Wonju 220 710, Korea
    J Biochem Mol Biol 37:480-6. 2004
    ..These results suggest that cobalt chloride is able to induce the apoptotic activity in C6 glioma cells, and its apoptotic mechanism may be associated with signal transduction via MAP kinase (ERK 1/2)...
  24. ncbi Extracellularly regulated kinases 1/2 (p44/42 mitogen-activated protein kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 beta-cell line and islets of Langerhans
    Christine Longuet
    Unité Institut National de la Santé et de la Recherche Médecale U376, Centre Hospitalier Universitaire Arnaud de Villeneuve, 371 rue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
    Endocrinology 146:643-54. 2005
    ..using MEK1/2, the MAPK kinase inhibitor PD98059 or using small interfering RNA-mediated silencing of ERK1 and ERK2 expressions resulted in partial inhibition of glucose-induced insulin release, indicating that ERK1/2 pathway ..
  25. ncbi Reactive oxygen species and ERK 1/2 mediate monocyte chemotactic protein-1-stimulated smooth muscle cell migration
    I Chung Lo
    Department of Cell Biology and Anatomy, National Cheng Kung University Medical College, Taiwan
    J Biomed Sci 12:377-88. 2005
    ....
  26. ncbi Extracellular signal-regulated kinase-1 and -2 are activated by gastric luminal injury in dorsal root ganglion neurons via N-methyl-D-aspartate receptors
    R Schicho
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Neuroscience 134:505-14. 2005
    ..The extracellular signal-regulated kinase-1 and -2 pathway therefore may not only be of importance for somatic but also for visceral nociception...
  27. pmc Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2
    Tiina M Kauppinen
    Department of Neurology, University of California, San Francisco, and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Proc Natl Acad Sci U S A 103:7136-41. 2006
    ..These inhibitors also blocked PARP-1 activation and PARP-1-mediated death in astrocytes. siRNA down-regulation of ERK2 expression in astrocytes also blocked PARP-1 activation and cell death...
  28. pmc Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta stimulate extracellular signal-regulated kinase 1/2 signaling by accelerating recycling through the endocytic recycling compartment
    Yaara Kapp-Barnea
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Biol Cell 17:4130-41. 2006
    ..Together, our results demonstrate a novel role for NCS-1 and PI4Kbeta in regulating ERK1/2 signaling and inflammatory reactions in mast cells. Our results further identify the ERC as a crucial determinant in controlling ERK1/2 signaling...
  29. ncbi DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation
    Malka Cohen-Armon
    Neufeld Cardiac Research Institute, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Cell 25:297-308. 2007
    ..PARP-1 was intensively activated and thereby polyADP-ribosylated by a direct interaction with phosphorylated ERK2, and the activated PARP-1 dramatically increased ERK2-catalyzed phosphorylation of the transcription factor Elk1...
  30. pmc Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Mol Pain 3:4. 2007
    ..The stimuli were mechanical (repeated pinching), thermal (immersion in water at 52 degrees C) or chemical (injection of 2% formaldehyde)...
  31. ncbi Nitric oxide attenuates endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 in vascular smooth muscle cells by a cGMP-dependent pathway
    Ali Bouallegue
    Laboratory of Cell Signaling, Montreal Diabetes Research Centre, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Technopole Angus Campus, and Department of Medicine, University of Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 293:H2072-9. 2007
    ..It may be suggested that NO-induced generation of cGMP contributes to the inhibition of ET-1-induced mitogenic and hypertrophic responses in VSMCs...
  32. doi Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts
    Erik R Olson
    Department of Physiology and Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272 0095, USA
    Hypertension 51:704-11. 2008
    ....
  33. pmc Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells
    Muyao Li
    Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont
    J Cell Physiol 217:377-87. 2008
    ..Therefore, activation of IGF-1R signaling influences VSMC function in old rats and may contribute to the increased risk for atherosclerosis...
  34. pmc Stimulus-specific activation and actin dependency of distinct, spatially separated ERK1/2 fractions in A7r5 smooth muscle cells
    Susanne Vetterkind
    Department of Health Sciences, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 7:e30409. 2012
    ..Our results show that (1) at least two ERK1/2 fractions are regulated separately by specific stimuli, and that (2) the association of ERK1/2 with the actin cytoskeleton regulates the outcome of ERK1/2 signaling...
  35. ncbi Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice
    F Karim
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 21:3771-9. 2001
    ..We show that activation of mGluR1 and mGluR5 leads to activation of ERK1 and ERK2 in the spinal cord...
  36. ncbi The receptor for advanced glycation end-products (RAGE) directly binds to ERK by a D-domain-like docking site
    Katsuya Ishihara
    Discovery Biology, Tsukuba Research Institute, Novartis Pharma K K, Okubo 8, Tsukuba shi, Ibaraki 300 2611, Japan
    FEBS Lett 550:107-13. 2003
    ..These data suggest that ERK may play a role in RAGE signaling through direct interaction with RAGE...
  37. ncbi Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
    Silvia D M Santos
    European Molecular Biology Laboratory EMBL, Cell Biology and Biophysics, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nat Cell Biol 9:324-30. 2007
    ..These results show that growth factor context determines the topology of the MAPK signalling network and that the resulting dynamics govern cell fate...
  38. doi Estrogen-dependent facilitation on spinal reflex potentiation involves the Cdk5/ERK1/2/NR2B cascade in anesthetized rats
    Hsien Yu Peng
    Department of Physiology, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan
    Am J Physiol Endocrinol Metab 297:E416-26. 2009
    ....
  39. doi Static pressure drives proliferation of vascular smooth muscle cells via caveolin-1/ERK1/2 pathway
    Di Xian Luo
    Division of Pharmacoproteomics, Institute of Pharmacy and Pharmacology, Research Center of Life Science, University of South China, Hengyang, Hunan 421001, China
    Biochem Biophys Res Commun 391:1693-7. 2010
    ..Our data also showed that a siRNA-mediated caveolin-1 knock down increased ERK1/2 phosphorylation and VSMC proliferation. These results demonstrate that static pressure promotes VSMC proliferation via the Caveolin-1/ERK1/2 pathway...
  40. pmc Shear stress modulation of smooth muscle cell marker genes in 2-D and 3-D depends on mechanotransduction by heparan sulfate proteoglycans and ERK1/2
    Zhong Dong Shi
    Department of Biomedical Engineering, The City College of New York, The City University of New York, New York, New York, United States of America
    PLoS ONE 5:e12196. 2010
    ..We investigate the effects of these two types of fluid flows on the phenotypes of SMCs and MFBs and the underlying mechanotransduction mechanisms...
  41. doi Extracellular signal-regulated kinase 1/2 signaling promotes oligodendrocyte myelination in vitro
    Junhua Xiao
    Centre for Neuroscience Research, The University of Melbourne, Victoria, Australia
    J Neurochem 122:1167-80. 2012
    ..Collectively, these data identify that Erk1/2 signaling within oligodendrocytes exerts an important and direct effect to promote myelination...
  42. doi Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex
    Shingo Nemoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 303:H893-902. 2012
    ..These results suggest that in type 2 diabetic rats, pravastatin normalizes ET-1-induced contraction in aortic smooth muscle via a suppression of PP2A/KSR1/ERK activities after an enhancement of Src kinase activity...
  43. ncbi Vessel-specific stimulation of protein synthesis by nitric oxide synthase inhibition: role of extracellular signal-regulated kinases 1/2
    Fabrice M A C Martens
    Faculty of Pharmacy, Department of Pharmacology, Faculty of Medicine Université de Montréal, Montreal, Canada
    Hypertension 39:16-21. 2002
    ..This heterogeneous role of NO on vascular growth may explain the heterogeneity of vascular remodeling observed in essential hypertension, a condition associated with endothelial dysfunction...
  44. ncbi Mitochondrial extracellular signal-regulated kinases 1/2 (ERK1/2) are modulated during brain development
    Mariana Alonso
    Institute of Cellular Biology and Neurosciences, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    J Neurochem 89:248-56. 2004
    ....
  45. ncbi Blockade of rapid versus prolonged extracellularly regulated kinase 1/2 activation has differential effects on insulin-induced gene expression
    Adam B Keeton
    Department of Pathology, Division of Molecular and Cellular Pathology, Volker Hall, G019, 1670 University Boulevard, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Endocrinology 146:2716-25. 2005
    ....
  46. pmc Ethanol-induced modulation of hepatocellular extracellular signal-regulated kinase-1/2 activity via 4-hydroxynonenal
    Brante P Sampey
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver and Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 282:1925-37. 2007
    ....
  47. pmc Expanding the repertoire of an ERK2 recruitment site: cysteine footprinting identifies the D-recruitment site as a mediator of Ets-1 binding
    Olga Abramczyk
    Division of Medicinal Chemistry, University of Texas at Austin, Texas 78712, USA
    Biochemistry 46:9174-86. 2007
    Many substrates of ERK2 contain a D-site, a sequence recognized by ERK2 that is used to promote catalysis. Despite lacking a canonical D-site, the substrate Ets-1 is displaced from ERK2 by peptides containing one...
  48. pmc Extracellular signal-regulated kinase 1/2 activation, via downregulation of mitogen-activated protein kinase phosphatase 1, mediates sex differences in desoxycorticosterone acetate-salt hypertension vascular reactivity
    Fernanda R Giachini
    Medical College of Georgia, Department of Physiology, 1120 Fifteenth St, CA 2095, Augusta, GA 30912 3000, USA
    Hypertension 55:172-9. 2010
    ..In addition, mitogen-activated protein kinase phosphatase 1 and interleukin 10 play regulatory roles in this process...
  49. ncbi Altered extracellular signal-regulated kinase signal transduction by the muscarinic acetylcholine and metabotropic glutamate receptors after cerebral ischemia
    Norio Takagi
    Faculty of Pharmaceutical Sciences, Department of Pharmacology, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Biol Chem 277:6382-90. 2002
    ....
  50. pmc Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase
    Thomais Markou
    Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
    Biochem J 365:757-63. 2002
    ..However, the lack of phosphorylation at Ser-360, an identified phosphorylation site targeted by MAPKs, may indicate that MSK1 is not a direct substrate of ERK1/2 and p38 MAPK in adult rat cardiomyocytes...
  51. ncbi Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells
    Isabelle Briaud
    Pacific Northwest Research Institute, Seattle, Washington, USA
    Diabetes 52:974-83. 2003
    ..In contrast, glucose-induced p70(S6K) activation, in the same beta-cells, was mediated by a distinct signaling pathway independent of Ca(2+)/cAMP, most likely via mTOR-kinase acting as an "ATP-sensor."..
  52. ncbi ERK and p38 mediate high-glucose-induced hypertrophy and TGF-beta expression in renal tubular cells
    Hisayo Fujita
    Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Physiol Renal Physiol 286:F120-6. 2004
    ..These results demonstrate that ERK and p38 are activated in renal tubular cells of DM and may mediate HG-induced cellular hypertrophy and TGF-beta expression...
  53. ncbi Asymmetric activation of extracellular signal-regulated kinase 1/2 in rat vestibular nuclei by unilateral labyrinthectomy
    Min Sun Kim
    Vestibulocochlear Research Center and Department of Physiology, Wonkwang University School of Medicine, 344 2 Shinyong dong, Iksan 570 749, South Korea
    Brain Res 1011:238-42. 2004
    ..These results suggest that unilateral deafferentation of the vestibular system triggers intracellular signal pathways that activate ERK 1/2 in the VN...
  54. pmc Rapid effects of retinoic acid on CREB and ERK phosphorylation in neuronal cells
    Estela Cañón
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, 28029 Madrid, Spain
    Mol Biol Cell 15:5583-92. 2004
    ..These results demonstrate that RA, by a nongenomic mechanism, stimulates signaling pathways that lead to phosphorylation of transcription factors, which in turn activate the transcription of genes involved in neuronal differentiation...
  55. ncbi Extracellular signal-regulated kinase 1/2 signaling pathway in solitary nucleus mediates cholecystokinin-induced suppression of food intake in rats
    Gregory M Sutton
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Neurosci 24:10240-7. 2004
    ....
  56. ncbi Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes
    Natalia V Giltiay
    Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    J Lipid Res 46:2497-505. 2005
    ..These results suggest that ceramide and ERK mediate a pathway in the IL-1beta signaling cascade, which results in rapid posttranslational activation of C/EBPbeta...
  57. ncbi Insulin enhances growth hormone induction of the MEK/ERK signaling pathway
    Jie Xu
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, 35294, USA
    J Biol Chem 281:982-92. 2006
    ..These findings suggest that insulin may be necessary for sensitization of cells to GH-induced ERK1/2 activation and provides a potential cellular mechanism by which insulin promotes growth...
  58. ncbi MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBP
    Tsung Ting Tsai
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania19107, USA
    J Bone Miner Res 22:965-74. 2007
    ..However, the mechanism of hyperosmotic activation of TonEBP in disc cells is not known. Results of this study show that hypertonic activation of ERK signaling regulates transactivation activity of TonEBP, modulating its function...
  59. ncbi ERK1/2 signaling pathway modulates the airway smooth muscle cell phenotype in the rat model of chronic asthma
    Min Xie
    Department of Respiratory Medicine, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Respiration 74:680-90. 2007
    ..The extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway is one of the most important transduction pathways involved in the process of asthma; however, its role in the phenotypic transition of ASMCs remains unclear...
  60. ncbi Fas Ag-FasL coupling leads to ERK1/2-mediated proliferation of gastric mucosal cells
    Hanchen Li
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Am J Physiol Gastrointest Liver Physiol 294:G263-75. 2008
    ....
  61. ncbi Protection of transplant-induced hepatic ischemia/reperfusion injury with carbon monoxide via MEK/ERK1/2 pathway downregulation
    Takashi Kaizu
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Physiol Gastrointest Liver Physiol 294:G236-44. 2008
    ..The possible mechanism may include the downregulation of MEK/ERK1/2 signaling pathway with CO...
  62. ncbi Remote vs. ischaemic preconditioning: the differential role of mitogen-activated protein kinase pathways
    Marc Heidbreder
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Cardiovasc Res 78:108-15. 2008
    ..Since mitogen-activated protein kinases (MAPKs) were found to be implicated in the signalling of ischaemic preconditioning (IPC), we tested the hypothesis of a contribution of these protein kinases to remote preconditioning (RPC)...
  63. doi D1 receptor regulation of preprotachykinin-A gene by extracellular signal-regulated kinase pathway in striatal cultures
    Mihaela Sin
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Neuroreport 19:187-91. 2008
    ....
  64. doi Artepillin C derived from propolis induces neurite outgrowth in PC12m3 cells via ERK and p38 MAPK pathways
    Yoshio Kano
    Department of Occupational Therapy, School of Health Science, Kibi International University, 8 Iga machi, Takahashi City, Okayama, 716 8508, Japan
    Neurochem Res 33:1795-803. 2008
    ..These findings suggest that artepillin C-induced activation of p38 MAPK through the ERK signaling pathway is responsible for the neurite outgrowth of PC12m3 cells...
  65. doi Preischemic induction of TNF-alpha by physical exercise reduces blood-brain barrier dysfunction in stroke
    Miao Guo
    Department of Neurosurgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Cereb Blood Flow Metab 28:1422-30. 2008
    ..These results were negated and returned toward nonexercised values once TNF-alpha or ERK1/2 was blocked. We concluded that preischemic, exercise-induced TNF-alpha markedly decreases BBB dysfunction by using the ERK1/2 pathway...
  66. pmc The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts
    P Almela
    Department of Pharmacology, University School of Medicine, Murcia University, Murcia, Spain
    Br J Pharmacol 155:73-83. 2008
    ..The purpose of the present study was to evaluate the effects of morphine withdrawal on site-specific phosphorylation of TH in the heart...
  67. pmc MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides
    Patricia E Gallagher
    The Hypertension and Vascular Disease Center, Wake Forest Univ School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1032, USA
    Am J Physiol Cell Physiol 295:C1169-74. 2008
    ..Treatment of VSMCs with ANG II increased ERK1/ERK2 activity, which was significantly reduced by pretreatment with ANG-(1-7)...
  68. doi GAP1(IP4BP)/RASA3 mediates Galphai-induced inhibition of mitogen-activated protein kinase
    Houman Nafisi
    Ottawa Health Research Institute Neuroscience, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa K1H 8M5, Canada
    J Biol Chem 283:35908-17. 2008
    ..Our results provide a novel mechanism for dopamine D2S-induced inhibition of ERK1/2 and indicate that RASA3 links Galphai proteins to inhibit Gq-induced Ras/ERK1/2 activation...
  69. doi Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2
    Christophe Frémin
    INSERM U522, UPRES SeRAIC, IFR 140 Université de Rennes, Rennes, France
    Hepatology 49:930-9. 2009
    ..the specific role of the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase 1 (ERK1)/ERK2 pathway in the regulation of multiple cell cycles and long-term survival of normal hepatocytes...
  70. doi Erk1/2 promotes proliferation and inhibits neuronal differentiation of neural stem cells
    Bin Wang
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100190, China
    Neurosci Lett 461:252-7. 2009
    ..Our results showed that Erk1/2 played an important role in the interplay between cell-extrinsic cues and cell-intrinsic genetic mechanisms in neural stem cell biology...
  71. doi Involvement of ERK1/2 pathway in neuroprotection by salidroside against hydrogen peroxide-induced apoptotic cell death
    Shu Yu
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, 226001, People s Republic of China
    J Mol Neurosci 40:321-31. 2010
    ..Taken together, the results suggest that the neuroprotective effects of salidroside might be modulated by ERK signaling pathway, especially at the level or upstream of the caspase-3 activation...
  72. doi Role of angiotensin II in the remodeling induced by a chronic increase in flow in rat mesenteric resistance arteries
    Maud Cousin
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 6214, Institut National de la Santé et de la Recherche Médicale U771, Universite d Angers, Angers, France
    Hypertension 55:109-15. 2010
    ..Thus, a chronic rise in blood flow in resistance arteries induces a diameter enlargement involving NO and superoxide, whereas hypertrophy was associated with extracellular signal-regulated kinase 1/2 activation by angiotensin II...
  73. pmc High-glucose stimulation increases reactive oxygen species production through the calcium and mitogen-activated protein kinase-mediated activation of mitochondrial fission
    Tianzheng Yu
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Antioxid Redox Signal 14:425-37. 2011
    ..These results demonstrate that high-glucose stimulation induces the activation of mitochondrial fission via signals mediated by intracellular Ca(2+) and ERK1/2...
  74. pmc Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways
    Feng Gao
    Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    J Zhejiang Univ Sci B 11:608-17. 2010
    ..These findings demonstrated a novel and effective treatment strategy against MSC apoptosis in cell transplantation...
  75. doi Effect of Chaihu Shugan San and its components on expression of ERK1/2 mRNA in the hippocampus of rats with chronic mild unpredicted stress depression
    Su E Wang
    Institute of Integrated Medicine Key Unit of SATCM for Traditional Chinese Medicine Gan, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:93-100. 2011
    ..To explore the antidepressant effect and mechanism of Chaihu Shugan San (CHSGS) composition, a compound traditional Chinese herb medicine and its components...
  76. doi Matrine inhibits disturbed flow-enhanced migration via downregulation of ERK1/2-MLCK signaling vascular smooth muscle cells
    Ping Zhu
    Cardiovascular Surgery Department, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academic of Medical Sciences, Guangzhou, People s Republic of China
    Ann Vasc Surg 26:268-75. 2012
    ..To investigate the effects of matrine on the vascular smooth muscle cell (VSMC) migration modulated by disturbed flow and their underlying molecular mechanisms in vitro...
  77. pmc Phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 may not always represent its kinase activity in a rat model of focal cerebral ischemia with or without ischemic preconditioning
    T Takahashi
    Department of Neurosurgery and Stanford Stroke Center, Stanford University, Stanford, CA, USA
    Neuroscience 209:155-60. 2012
    ..In conclusion, protein phosphorylation levels of ERK1/2 do not always correspond to kinase activity, thus, measuring the true kinase activity is essential...
  78. doi The adipokine chemerin augments vascular reactivity to contractile stimuli via activation of the MEK-ERK1/2 pathway
    N S Lobato
    Department of Biological Sciences, Federal University of Goias, Jataí, GO, Brazil
    Life Sci 91:600-6. 2012
    ..In the present study we tested the hypothesis that the adipokine chemerin increases vascular contractile responses via activation of ET-1/ET-1 receptors-mediated pathways...
  79. doi The expression of NR2B subunit of NMDA receptor in the suprachiasmatic nucleus of Wistar rats and its role in glutamate-induced CREB and ERK1/2 phosphorylation
    Zdenka Bendova
    Institute of Physiology, Academy of Sciences of the Czech Republic v v i, Prague, Czech Republic
    Neurochem Int 61:43-7. 2012
    ....
  80. doi GIT1Y321 phosphorylation is required for ERK1/2- and PDGF-dependent VEGF secretion from osteoblasts to promote angiogenesis and bone healing
    Ze Rui
    Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, Nanjing 210029, PR China
    Int J Mol Med 30:819-25. 2012
    ..Furthermore, GIT1 is a seminal signaling protein regulating bone healing...
  81. doi Magnetic labeling of pancreatic β-cells modulates the glucose- and insulin-induced phosphorylation of ERK1/2 and AKT
    Hoe Suk Kim
    Department of Radiology, Seoul National University Hospital, Daehangno, Jongno gu, Korea
    Contrast Media Mol Imaging 8:20-6. 2013
    ..This study demonstrates that SPIO labeling alters some fundamental functional variables, at least in INS-1 cells, through modulation of the glucose- or insulin-induced activation of ERK1/2 and AKT, which leads to insulin biosynthesis...
  82. doi Activation of spinal chemokine receptor CXCR3 mediates bone cancer pain through an Akt-ERK crosstalk pathway in rats
    Xue Hai Guan
    Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan 430030, PR China
    Exp Neurol 263:39-49. 2015
    ..Our results demonstrated that the activation of spinal chemokine receptor CXCR3 mediated BCP through Akt and ERK 1/2 kinase, and also indicated a crosstalk between PI3K/Akt and Raf/MEK/ERK signaling pathways under the BCP condition. ..
  83. pmc Sevoflurane post-conditioning protects isolated rat hearts against ischemia-reperfusion injury via activation of the ERK1/2 pathway
    Hong Xie
    Department of Anesthesiology, the Second Affiliated Hospital of Soochow University, Suzhou 215000, China
    Acta Pharmacol Sin 35:1504-13. 2014
    ..To investigate the role of extracellular signal-regulated kinases (ERKs) in sevoflurane post-conditioning induced cardioprotection in vitro...
  84. pmc Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen Activator Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis
    Faith Hannah Nutter
    Academic Unit of Nephrology, Department of Infection and Immunity, Medical School, University of Sheffield, Sheffield, England
    PLoS ONE 10:e0137321. 2015
    ..Thus inhibition of ERK1/2 activation has no therapeutic effect on kidney fibrosis in SNx possibly due to increased compensatory activation of the p38 and JNK signalling pathways with subsequent upregulation of PAI-1. ..
  85. doi Mitogen-Activated Protein Kinases Are Activated in Placental Injury in Rat Model of Acute Pancreatitis in Pregnancy
    Teng Zuo
    From the Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China
    Pancreas 45:850-7. 2016
    ..To establish a rat model of acute pancreatitis in pregnancy (APIP) and evaluate its general presentations, assess placental injury, and discuss possible mechanisms...
  86. ncbi Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activation
    S P Soltoff
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Biol Chem 273:23110-7. 1998
    ..that the activation of G-protein-coupled P2Y2 receptors by extracellular ATP and UTP stimulated MAP (p42 ERK2) kinase by a mechanism that was dependent on the elevation of [Ca2+]i and the activation of related adhesion focal ..
  87. ncbi Prostacyclin induces apoptosis of vascular smooth muscle cells by a cAMP-mediated inhibition of extracellular signal-regulated kinase activity and can counteract the mitogenic activity of endothelin-1 or basic fibroblast growth factor
    Rung Chi Li
    Babraham Institute, Babraham, Cambridge, UK
    Circ Res 94:759-67. 2004
    ..However, ERK stimulation by a selective EP4 receptor agonist, suggests that prostanoids may have diverse and complex roles in VSMC physiology...
  88. ncbi Activation of the extracellular-signal regulated protein kinase pathway in human glomerulopathies
    Takao Masaki
    Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia
    J Am Soc Nephrol 15:1835-43. 2004
    ..ERK activation may promote renal repair through tubular proliferation while promoting renal fibrosis via proliferation of glomerular and interstitial myofibroblasts...
  89. ncbi Conditional overexpression of the wild-type Gs alpha as the gsp oncogene initiates chronic extracellularly regulated kinase 1/2 activation and hormone hypersecretion in pituitary cell lines
    D Romano
    Unite Mixte de Recherche 6544, Institut Federatif de Recherche Jean Roche, Faculte de Medecine Nord, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
    Endocrinology 148:2973-83. 2007
    ..Overexpression of the wild-type G(s)alpha protein as the gsp oncogene initiated chronic activation of endogenous prolactin synthesis and release, as well as chronic activation of ERK1/2-sensitive human prolactin and GH promoters...
  90. ncbi Sequential actions of ERK1/2 on the AP-1 transcription factor allow temporal integration of metabolic signals in pancreatic beta cells
    Dominique A Glauser
    Fondation pour Recherches Medicales, University of Geneva, Switzerland
    FASEB J 21:3240-9. 2007
    ..This ERK1/2-AP-1 module can function as a temporal integrator converting metabolic stimuli of different durations into differential transcriptional outputs...
  91. ncbi 17beta-estradiol induces the translocation of the estrogen receptors ESR1 and ESR2 to the cell membrane, MAPK3/1 phosphorylation and proliferation of cultured immature rat Sertoli cells
    Thaís F G Lucas
    Section of Experimental Endocrinology, Department of Pharmacology, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil
    Biol Reprod 78:101-14. 2008
    ..In addition, activation of ESR1 and/or ESR2 by E(2) is involved in proliferation of immature Sertoli cells. The estrogen actions in Sertoli cells might be a key step mediating cellular events important for spermatogenesis and fertility...
  92. doi Estrogen exerts concentration-dependent pro-and anti-hypertrophic effects on adult cultured ventricular myocytes. Role of NHE-1 in estrogen-induced hypertrophy
    Ana Kilic
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Medical Sciences Building, University of Western Ontario, London, Ontario, Canada N6A 5C1
    J Mol Cell Cardiol 46:360-9. 2009
    ..These effects may further our understanding of the role of estrogen in heart disease particularly associated with hypertrophy...
  93. doi SH2B1beta enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway
    Wei Fan Lin
    Institute of Molecular Medicine, Department of Life Science and Brain Research Center, National Tsing Hua University, 101 Section 2 Kuang Fu Road, Hsinchu, Taiwan
    Cell Signal 21:1060-72. 2009
    ..Taken together, our results demonstrate, for the first time, that SH2B1beta enhances FGF1-induced neurite outgrowth in PC12 cells mainly through MEK-ERK1/2-STAT3-Egr1 pathway...
  94. pmc Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway
    Herng Sheng Lee
    Department of Pathology, Tri Service General Hospital and National Defense Medical Center, Neihu District, Taipei City, Taiwan
    Arthritis Res Ther 11:R48. 2009
    ..Synovial cells are potential sources of inflammatory mediators in bacterial-induced arthritis but their involvement in the inflammatory response to Candida albicans-induced septic arthritis is largely unknown...
  95. doi Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect
    Youngmi Kim
    School of Biological Sciences, College of Natural Sciences, Kangwon National University, Chunchon 200 701, Republic of Korea
    Eur J Pharmacol 612:131-42. 2009
    ..A molecular dynamics simulation showed binding of celastrol to a large pocket in ERK2, which serves as the ATP-binding site...
  96. doi SDF-1α inhibits hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells through PI3K/Akt and ERK1/2 signaling pathways
    Qi Yin
    Research Center for Cardiac Regenerative Medicine, the Ministry of Health, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China
    Mol Biol Rep 38:9-16. 2011
    ..These data also imply that the anti-apoptotic effect mediated by SDF-1α may enhance cell survival after cell transplantation...
  97. ncbi [Effects of free fatty acids on insulin signaling proteins in rat islet cells]
    Qi Yu Guo
    Departmnent of Endocrinology, Navy General Hospital, Beijing 100037, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 18:283-6. 2002
    ..To investigate whether free fatty acid impair insulin signaling proteins to inhibit insulin action in rat islet cells...
  98. pmc Elevated activation of ERK1 and ERK2 accompany enhanced liver injury following alcohol binge in chronically ethanol-fed rats
    Annayya R Aroor
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, 65212, USA
    Alcohol Clin Exp Res 35:2128-38. 2011
    ..We have therefore examined in rats the effect of single and repeat ethanol binge superimposed on chronic ethanol intake on liver injury, activation of mitogen-activated protein kinases (MAPKs), and gene expression...
  99. pmc Tonic, but not phasic corticosterone, constrains stress activatedextracellular-regulated-kinase 1/ 2 immunoreactivity within the hypothalamic paraventricular nucleus
    C D Osterlund
    Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, CO 80309, USA
    J Neuroendocrinol 23:1241-51. 2011
    ....
  100. pmc Extracellular signal-regulated kinase 2 signaling in the hippocampal dentate gyrus mediates the antidepressant effects of testosterone
    Nicole Carrier
    Department of Biomedical Sciences, Program in Neurosciences, College of Medicine, Florida State University, USA
    Biol Psychiatry 71:642-51. 2012
    ..In this study, we sought to investigate the molecular mechanisms underlying the antidepressant effects of testosterone within the hippocampus, an area that is fundamental in the etiology of depression...
  101. pmc Selective inhibition of extracellular signal-regulated kinases 1/2 blocks nerve growth factor to brain-derived neurotrophic factor signaling and suppresses the development of and reverses already established pain behavior in rats
    Y Matsuoka
    Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Neuroscience 206:224-36. 2012
    ..siRNA experiments indicated that both ERK1 or ERK2 can signal suggesting that both pathways must be blocked to prevent NGF-induced increase in BDNF mRNA. I.p...

Research Grants6

  1. GLU6PASE AND 6P2K/FBASE GENE REGULATION IN SEPSIS
    SUBIR MAITRA; Fiscal Year: 2001
    ..The results of this study are essential to understand the molecular basis of deranged metabolism in sepsis. Understanding the mechanism might be useful for developing appropriate therapeutic intervention during sepsis. ..
  2. Identification of a new protein that binds Src and PKC
    STEPHEN SOLTOFF; Fiscal Year: 2004
    ..Future efforts will determine if this new protein alters cell morphology, tight junction formation, or other functions in salivary cells. ..
  3. Neural regulation of effort in goal-directed behaviors
    Jeremy Day; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  4. Cellular Regulation of Angiotensin Converting Enzyme 2 (ACE2)
    Patricia Gallagher; Fiscal Year: 2009
    ..The regulation of ACE2 may be critical to maintaining the normal function of the renin-angiotensin system in the brain. ..
  5. Tat-mediated brain endothelial cell dysfunction
    Michal Toborek; Fiscal Year: 2009
    ..In a broader aspect, this proposal will contribute to better knowledge of how injury to brain endothelium can contribute to the development of neuroAIDS. ..
  6. The function of RhoBTB proteins
    STEPHEN PAUL SOLTOFF; Fiscal Year: 2010
    ..The results of these studies may reveal a new pathway involved in the development of cancer and advance our understanding of the basic biology of transformation. ..