Genomes and Genes

Species

Mafa

Summary

Gene Symbol: Mafa
Description: MAF bZIP transcription factor A
Alias: RGD1562627, transcription factor MafA, v-maf avian musculoaponeurotic fibrosarcoma oncogene A, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A, v-maf musculoaponeurotic fibrosarcoma oncogene homolog A
Species: rat

Top Publications

  1. ncbi GSK-3-mediated phosphorylation enhances Maf-transforming activity
    Nathalie Rocques
    Institut Curie, Centre de Recherche, Orsay F 91405, France
    Mol Cell 28:584-97. 2007
  2. doi Activation of PPARδ up-regulates the expression of insulin gene transcription factor MafA and ameliorates glucose-induced insulin secretion impaired by palmitate
    Mingming Cao
    Division of Endocrinology, West China Hospital of Sichuan University, 37 Guoxuexiang, Chengdu 610041, Sichuan, China
    Mol Cell Biochem 366:183-9. 2012
  3. pmc Preventing p38 MAPK-mediated MafA degradation ameliorates β-cell dysfunction under oxidative stress
    Ilham El Khattabi
    Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Endocrinol 27:1078-90. 2013
  4. pmc Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells
    Chunli Shao
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    J Biol Chem 284:3117-24. 2009
  5. pmc p38 MAPK is a major regulator of MafA protein stability under oxidative stress
    Takuma Kondo
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Endocrinol 23:1281-90. 2009
  6. pmc Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells
    C Aguayo-Mazzucato
    Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetologia 54:583-93. 2011

Detail Information

Publications6

  1. ncbi GSK-3-mediated phosphorylation enhances Maf-transforming activity
    Nathalie Rocques
    Institut Curie, Centre de Recherche, Orsay F 91405, France
    Mol Cell 28:584-97. 2007
    ..We also demonstrate that GSK-3 triggers MafA sequential phosphorylation on residues S61, T57, T53, and S49, inducing its ubiquitination and degradation...
  2. doi Activation of PPARδ up-regulates the expression of insulin gene transcription factor MafA and ameliorates glucose-induced insulin secretion impaired by palmitate
    Mingming Cao
    Division of Endocrinology, West China Hospital of Sichuan University, 37 Guoxuexiang, Chengdu 610041, Sichuan, China
    Mol Cell Biochem 366:183-9. 2012
    ..Therefore, PPARδ may represent a new target for the treatment of obesity, hyperlipidemia, and type 2 diabetes. MafA is a β-cell-specific and glucose-regulated transcriptional activator for insulin gene expression and plays a ..
  3. pmc Preventing p38 MAPK-mediated MafA degradation ameliorates β-cell dysfunction under oxidative stress
    Ilham El Khattabi
    Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Endocrinol 27:1078-90. 2013
    The reduction in the expression of glucose-responsive insulin gene transcription factor MafA accompanies the development of β-cell dysfunction under oxidative stress/diabetic milieu...
  4. pmc Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells
    Chunli Shao
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    J Biol Chem 284:3117-24. 2009
    b>MafA is a transcriptional regulator expressed primarily in pancreatic beta cells. It binds to the RIPE3b/C1-binding site within the ins gene promoter, which plays a critical role in regulating ins gene expression in response to glucose...
  5. pmc p38 MAPK is a major regulator of MafA protein stability under oxidative stress
    Takuma Kondo
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Endocrinol 23:1281-90. 2009
    Mammalian MafA/RIPE3b1 is an important glucose-responsive transcription factor that regulates function, maturation, and survival of beta-cells...
  6. pmc Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells
    C Aguayo-Mazzucato
    Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetologia 54:583-93. 2011
    ..Important glucose-responsive transcription factors, Mafa and Pdx1, regulate genes involved in insulin synthesis and secretion, and have been implicated in late beta cell ..