Ltc4s

Summary

Gene Symbol: Ltc4s
Description: leukotriene C4 synthase
Alias: leukotriene C4 synthase, LTC4 synthase, leukotriene-C(4) synthase
Species: rat

Top Publications

  1. ncbi Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis
    R Petric
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, QC, Canada
    Biochim Biophys Acta 1254:207-15. 1995
  2. pmc Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia
    Wei Zhang
    From the The State University of New York College of Nanoscale Science and Engineering, Albany, New York 12203, Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, and
    J Biol Chem 290:5015-27. 2015
  3. ncbi [Expression of 5-lipoxygenase in hippocampal CA1 neuronal damage following global cerebral ischemia in rats]
    Wenjian Chen
    Department of Pharmacology, Hangzhou Normal University, Hangzhou, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 42:61-6. 2013
  4. ncbi Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats
    Shu Long Yang
    Institute of Pharmacology Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
    J Surg Res 140:36-44. 2007
  5. doi Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain
    Masamichi Okubo
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Glia 58:599-610. 2010
  6. pmc Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model
    Kui Fen Ma
    Institute of Pharmacology and Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang Province, China
    World J Gastroenterol 14:2748-56. 2008
  7. doi High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris
    Anders Wetterholm
    Department of Medical Biochemistry and Biophysics, Division for Chemistry 2, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Protein Expr Purif 60:1-6. 2008
  8. ncbi Leukotriene C4 synthase promoter driven expression of GFP reveals cell specificity
    Tobias Strid
    Division of Cell Biology, Department of Clinical and Experimental Medicine, Linkoping University, SE 58185 Linkoping, Sweden
    Biochem Biophys Res Commun 366:80-5. 2008
  9. ncbi Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4
    A J Jame
    Division of Infection, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 37:880-92. 2007
  10. ncbi Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway
    Shu Long Yang
    Institute of Pharmacology and Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
    Pharmacology 80:11-20. 2007

Scientific Experts

  • Masayoshi Abe
  • Shu Long Yang
  • Yi Jia Lou
  • Wei Zhang
  • Wenjian Chen
  • Masamichi Okubo
  • Anders Wetterholm
  • Tobias Strid
  • Kui Fen Ma
  • Yin Kong
  • Sven Hammarstrom
  • Li Jun Chen
  • A J Jame
  • Dan Xu
  • Mats Soderstrom
  • Jesper Svartz
  • Jesper Z Haeggstrom
  • O Schroder
  • Asim K Mandal
  • Oliver Schroder
  • Judith A Stolwijk
  • José C Gonzalez-Cobos
  • Xuexin Zhang
  • Khalid Matrougui
  • Mohamed Trebak
  • Chengtan Li
  • Jianbo Zhao
  • Xiaoyan Zhang
  • Lihui Zhang
  • Huayang Han
  • Erqing Wei
  • Kimiko Kobayashi
  • Koichi Noguchi
  • Hiroki Yamanaka
  • Hong Yu Yang
  • Dan Yan Zhu
  • Luo Yang Qi
  • Said Eshaghi
  • Zhe Chen
  • Pär Nordlund
  • Daniel Martinez Molina
  • S T Holgate
  • I Sayers
  • P M Lackie
  • A M Cazaly
  • A P Sampson
  • Xin Huang
  • Hai fei Chen
  • J F Penrose
  • Yixuan Shi
  • Elisabeth Hallin
  • K Shimada
  • P J Jakobsson
  • J Z Haeggstrom
  • H Qiu
  • M Sjostrom
  • Jilly F Evans
  • Douglas Wisniewski
  • Douglas Miller
  • Peter Christmas
  • Roy J Soberman
  • Bradley T Hyman
  • Jesse Skoch
  • Shihua Xu
  • Brian J Bacskai
  • Ting ting D Yamin
  • Mattias Sjöström
  • Hong Qiu
  • Jurgen Stein
  • Per Johan Jakobsson
  • R Petric
  • S B Mustafa
  • S A Weinman
  • P H Weigel
  • J Navarro
  • D E Goeger
  • A W Ford-Hutchinson
  • D W Nicholson

Detail Information

Publications18

  1. ncbi Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis
    R Petric
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, QC, Canada
    Biochim Biophys Acta 1254:207-15. 1995
    ..We have partially purified and characterized LTC4 synthase, the enzyme responsible for cysteinyl LT formation, from rat renal microsomes and have investigated this ..
  2. pmc Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia
    Wei Zhang
    From the The State University of New York College of Nanoscale Science and Engineering, Albany, New York 12203, Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, and
    J Biol Chem 290:5015-27. 2015
    Leukotriene-C4 synthase (LTC4S) generates LTC4 from arachidonic acid metabolism. LTC4 is a proinflammatory factor that acts on plasma membrane cysteinyl leukotriene receptors...
  3. ncbi [Expression of 5-lipoxygenase in hippocampal CA1 neuronal damage following global cerebral ischemia in rats]
    Wenjian Chen
    Department of Pharmacology, Hangzhou Normal University, Hangzhou, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 42:61-6. 2013
    ..To determine 5-lipoxygenase (5-LOX) expression and the effect of zileuton, a selective 5-LOX inhibitor,on hippocampal neuron injury induced by global cerebral ischemia in rats...
  4. ncbi Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats
    Shu Long Yang
    Institute of Pharmacology Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
    J Surg Res 140:36-44. 2007
    ..leukotrienes (LTs), the first committed synthesis step of which is that LTC4 synthesis enzymes including leukotriene C4 synthase (LTC4S), microsomal glutathione-S-transferase (mGST)2, and mGST3-catalyzed LTA4 and reduced glutathione (..
  5. doi Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain
    Masamichi Okubo
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Glia 58:599-610. 2010
    ..of LT synthases (5-lipoxygenase; 5-LO, Five lipoxygenase activating protein; FLAP, LTA4 hydrolase; LTA4h and LTC4 synthase; LTC4s) and receptors (BLT1, 2 and CysLT1, 2) mRNAs in the rat spinal cord...
  6. pmc Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model
    Kui Fen Ma
    Institute of Pharmacology and Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang Province, China
    World J Gastroenterol 14:2748-56. 2008
    ....
  7. doi High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris
    Anders Wetterholm
    Department of Medical Biochemistry and Biophysics, Division for Chemistry 2, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Protein Expr Purif 60:1-6. 2008
    Leukotriene C(4) synthase (LTC4S) is a member of the MAPEG family of integral membrane proteins and catalyzes the conjugation of leukotriene A(4) with glutathione to form leukotriene C(4), a powerful mediator of allergic inflammation and ..
  8. ncbi Leukotriene C4 synthase promoter driven expression of GFP reveals cell specificity
    Tobias Strid
    Division of Cell Biology, Department of Clinical and Experimental Medicine, Linkoping University, SE 58185 Linkoping, Sweden
    Biochem Biophys Res Commun 366:80-5. 2008
    ..In contrast dimethyl sulfoxide did not affect promoter activity...
  9. ncbi Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4
    A J Jame
    Division of Infection, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 37:880-92. 2007
    ....
  10. ncbi Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway
    Shu Long Yang
    Institute of Pharmacology and Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
    Pharmacology 80:11-20. 2007
    Leukotriene (LT) C4 (LTC4) synthesis enzymes including LTC4 synthase (LTC4S), microsomal glutathione S-transferase (MGST) 2 and MGST3 can all conjugate LTA4 and reduced glutathione (GSH) to form LTC4, which is related to hepatic ischemia/..
  11. ncbi Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats
    Shu Long Yang
    Institute of Pharmacology Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
    Biochem Pharmacol 73:724-35. 2007
    ..The protein expressions of LTC4 synthesis enzymes including LTC4 synthase (LTC4S), microsomal glutathione-S-transferase (mGST)2 and mGST3 were detected with immunoblotting, the LTC4 ..
  12. ncbi Identification of regions of leukotriene C4 synthase which direct the enzyme to its nuclear envelope localization
    Jesper Svartz
    Division of Cell Biology, Department of Biomedicine and Surgery, Linkoping University, Linkoping, Sweden
    J Cell Biochem 98:1517-27. 2006
    ..converted to LTC4 by conjugation with glutathione, a reaction catalyzed by the integral membrane protein LTC4 synthase (LTC4S), which is localized on the NE and endoplasmic reticulum (ER)...
  13. ncbi Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis
    O Schroder
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, 17 177 Stockholm, Sweden
    Cell Mol Life Sci 62:87-94. 2005
    ..The committed step in cys-LT biosynthesis is catalyzed by leukotriene C(4) synthase (LTC4S) as well as microsomal glutathione S-transferase type 2 (MGST2) and type 3 (MGST3)...
  14. pmc The membrane organization of leukotriene synthesis
    Asim K Mandal
    Department of Medicine, Massachusetts General Hospital, 149 The Navy Yard, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:6587-92. 2004
    ..The results indicate that the formation of LTC(4) and LTB(4) may be determined by the compartmentalization of biosynthetic enzymes in discrete molecular complexes...
  15. ncbi Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs
    Oliver Schroder
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, S 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 312:271-6. 2003
    ..Hence, it seems feasible to design enzyme inhibitors, which simultaneously target several members of this protein family to yield compounds with increased anti-inflammatory action...
  16. ncbi Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone
    Masayoshi Abe
    Department of Pharmacology, School of Medicine, Fukuoka University, Fukuoka, Japan
    J Cell Physiol 196:154-64. 2003
    ..In consideration of RA-differentiation therapy, it may be of pathophysiological relevance that the antineoplastic agents potentiate RA-induced, steroid-sensitive, induction of LTC(4) S in RBL-1 cells...
  17. ncbi cDNA cloning and expression of rat leukotriene C(4) synthase: elevated expression in rat basophilic leukemia-1 cells after treatment with retinoic acid
    M Abe
    Department of Pharmacology, School of Medicine, Fukuoka University, Japan
    Prostaglandins Leukot Essent Fatty Acids 67:319-26. 2002
    ..This cDNA probe and antibody may be useful for investigating the roles of cysLTs in various experimental models of rats...
  18. ncbi Expression and regulation of leukotriene-synthesis enzymes in rat liver cells
    K Shimada
    Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX, USA
    Hepatology 28:1275-81. 1998
    ..cLT production are poorly defined, and the expression of the LT-synthesis enzymes, 5-lipoxygenase (5-LO) and LTC4 synthase (LTC4-S), in liver cells has never been demonstrated...