Lpl

Summary

Gene Symbol: Lpl
Description: lipoprotein lipase
Alias: lipoprotein lipase
Species: rat

Top Publications

  1. ncbi Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats
    T Teruel
    Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, Complutense University, 28040, Madrid, Spain
    Diabetologia 48:1180-8. 2005
  2. pmc Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue
    Valentina Sukonina
    Department of Medical Biosciences, Umea University, SE 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 103:17450-5. 2006
  3. ncbi Acute diabetes moderates trafficking of cardiac lipoprotein lipase through p38 mitogen-activated protein kinase-dependent actin cytoskeleton organization
    Min Suk Kim
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada
    Diabetes 57:64-76. 2008
  4. doi Protein kinase D is a key regulator of cardiomyocyte lipoprotein lipase secretion after diabetes
    Min Suk Kim
    Faculty of Pharmaceutical Sciences, Vancouver, BC, Canada
    Circ Res 103:252-60. 2008
  5. pmc Cold acclimation induces physiological cardiac hypertrophy and increases assimilation of triacylglycerol metabolism through lipoprotein lipase
    Y Cheng
    Department of Physiology, Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Biochim Biophys Acta 1781:618-26. 2008
  6. ncbi The distribution of lipoprotein lipase in rat adipose tissue. Changes with nutritional state engage the extracellular enzyme
    Gengshu Wu
    Department of Medical Biosciences, Physiological Chemistry, Umea University, SE 90185 Umeå, Sweden
    J Biol Chem 278:11925-30. 2003
  7. ncbi Down-regulation of adipose tissue lipoprotein lipase during fasting requires that a gene, separate from the lipase gene, is switched on
    Martin Bergo
    Department of Medical Bioscience, Umea University, S 901 87 Umea, Sweden
    J Biol Chem 277:11927-32. 2002
  8. doi Maternal undernutrition leads to elevated hepatic triglycerides in male rat offspring due to increased expression of lipoprotein lipase
    Wei Fen Zhu
    Department of Pediatrics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P R China
    Mol Med Rep 13:4487-93. 2016
  9. pmc Changes in white adipose tissue metabolism induced by resveratrol in rats
    Goiuri Alberdi
    Department of Nutrition and Food Science, Faculty of Pharmacy, University of Pais Vasco, Paseo de la Universidad 7, 01006 Vitoria, Spain
    Nutr Metab (Lond) 8:29. 2011
  10. pmc ShRNA-mediated gene silencing of lipoprotein lipase improves insulin sensitivity in L6 skeletal muscle cells
    Majib Jan
    Department of Chemistry and Biochemistry, California State University Northridge, Northridge, CA 91330 8262, USA
    Biochem Biophys Res Commun 462:33-7. 2015

Scientific Experts

  • Brian Rodrigues
  • David Hauton
  • Nosratola D Vaziri
  • G Annuzzi
  • M Yamaguchi
  • Miquel Llobera
  • Gengshu Wu
  • G C Shearer
  • Maria C Izar
  • Weiwei Ma
  • Adam E Mullick
  • Ying Wang
  • Ashraf Abrahani
  • Amy Pei Ling Chiu
  • Dahai Zhang
  • Min Suk Kim
  • Thomas Olivecrona
  • Andrea Wan
  • Israel Vlodavsky
  • Thomas Pulinilkunnil
  • Su Jin Kim
  • David Ricart-Jané
  • Gunilla Olivecrona
  • Ding An
  • Mathieu Laplante
  • Prasanth Puthanveetil
  • Valentina Sukonina
  • Albert Casanovas
  • Wei Fen Zhu
  • Girish Kewalramani
  • Majib Jan
  • Roger Savonen
  • M Dolores López-Tejero
  • Fulong Wang
  • Nathaniel Lal
  • Yuanhui Ma
  • Katharina Neumaier
  • Olessia Kroupa
  • Jun Pil Jee
  • Sanjoy Ghosh
  • Riya Ganguly
  • Yves Deshaies
  • Goiuri Alberdi
  • Xuan Shi
  • Fang Wang
  • Hong Wang
  • Ujendra Kumar
  • You Guo Niu
  • Yoon Shin Cho
  • Y Cheng
  • P Perron
  • Robert Ringseis
  • Cuilan Nian
  • Takahiro Shimizu
  • Christopher H S McIntosh
  • M Panadero
  • M C Y Ng
  • Xue Hui Yu
  • T Teruel
  • Pei Chen
  • Dake Qi
  • Josee Lalonde
  • Tadashi Sato
  • Lionel Bey
  • Bahira Hussein
  • Zheng Shen
  • Ying Min Wang
  • Li Liang
  • Jian Fang Zhu
  • Magnus Hultin
  • Rudolf Zechner
  • Michaela Hiden
  • Jheem D Medh
  • Sanja Levak-Frank
  • James R Mead
  • Laura Blanco-Dolado
  • L Mantha
  • L D M C B Ferreira
  • Christian K Roberts
  • Frederic Picard
  • Martin Bergo
  • Shuaipeng Ma
  • Junniao Lv
  • Michael J Bround
  • Jintao Bao
  • Hongyan Shen
  • Xuyang Zhao
  • Shuxin Wang
  • Zeyang Li
  • James D Johnson

Detail Information

Publications64

  1. ncbi Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats
    T Teruel
    Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, Complutense University, 28040, Madrid, Spain
    Diabetologia 48:1180-8. 2005
    ..The genes studied were: (1) lipoprotein lipase (lpl), which is involved in lipid uptake; (2) hormone-sensitive lipase (hsl), which mobilises fatty acids ..
  2. pmc Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue
    Valentina Sukonina
    Department of Medical Biosciences, Umea University, SE 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 103:17450-5. 2006
    b>Lipoprotein lipase (LPL) has a central role in lipoprotein metabolism to maintain normal lipoprotein levels in blood and, through tissue specific regulation of its activity, to determine when and in what tissues triglycerides are unloaded...
  3. ncbi Acute diabetes moderates trafficking of cardiac lipoprotein lipase through p38 mitogen-activated protein kinase-dependent actin cytoskeleton organization
    Min Suk Kim
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada
    Diabetes 57:64-76. 2008
    ..Our objective was to determine the mechanisms by which AMP-activated protein kinase (AMPK) augments cardiac lipoprotein lipase (LPL), the enzyme that provides the heart with the majority of its fatty acid.
  4. doi Protein kinase D is a key regulator of cardiomyocyte lipoprotein lipase secretion after diabetes
    Min Suk Kim
    Faculty of Pharmaceutical Sciences, Vancouver, BC, Canada
    Circ Res 103:252-60. 2008
    ..fatty acid (FA) for energy supply and does so by multiple mechanisms including hydrolysis of lipoproteins by lipoprotein lipase (LPL) positioned at the vascular lumen...
  5. pmc Cold acclimation induces physiological cardiac hypertrophy and increases assimilation of triacylglycerol metabolism through lipoprotein lipase
    Y Cheng
    Department of Physiology, Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Biochim Biophys Acta 1781:618-26. 2008
    The contribution of triacylglycerol to energy provision in the hypertrophied heart, mediated through lipoprotein lipase (LPL) is largely unknown and the contribution of very-low-density lipoprotein (VLDL) receptor to control of LPL ..
  6. ncbi The distribution of lipoprotein lipase in rat adipose tissue. Changes with nutritional state engage the extracellular enzyme
    Gengshu Wu
    Department of Medical Biosciences, Physiological Chemistry, Umea University, SE 90185 Umeå, Sweden
    J Biol Chem 278:11925-30. 2003
    b>Lipoprotein lipase (LPL) acts at the vascular endothelium. Earlier studies have shown that down-regulation of adipose tissue LPL during fasting is post-translational and involves a shift from active to inactive forms of the lipase...
  7. ncbi Down-regulation of adipose tissue lipoprotein lipase during fasting requires that a gene, separate from the lipase gene, is switched on
    Martin Bergo
    Department of Medical Bioscience, Umea University, S 901 87 Umea, Sweden
    J Biol Chem 277:11927-32. 2002
    During short term fasting, lipoprotein lipase (LPL) activity in rat adipose tissue is rapidly down-regulated. This down-regulation occurs on a posttranslational level; it is not accompanied by changes in LPL mRNA or protein levels...
  8. doi Maternal undernutrition leads to elevated hepatic triglycerides in male rat offspring due to increased expression of lipoprotein lipase
    Wei Fen Zhu
    Department of Pediatrics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P R China
    Mol Med Rep 13:4487-93. 2016
    ..pregnancy may lead to alterations in hepatic triglyceride content and the gene expression levels of hepatic lipoprotein lipase (LPL) in SGA male offspring...
  9. pmc Changes in white adipose tissue metabolism induced by resveratrol in rats
    Goiuri Alberdi
    Department of Nutrition and Food Science, Faculty of Pharmacy, University of Pais Vasco, Paseo de la Universidad 7, 01006 Vitoria, Spain
    Nutr Metab (Lond) 8:29. 2011
    ..Recently, this polyphenol has been shown to have body fat lowering effects. The aim of the present study was to assess some of the potential underlying mechanisms of action which take place in adipose tissue...
  10. pmc ShRNA-mediated gene silencing of lipoprotein lipase improves insulin sensitivity in L6 skeletal muscle cells
    Majib Jan
    Department of Chemistry and Biochemistry, California State University Northridge, Northridge, CA 91330 8262, USA
    Biochem Biophys Res Commun 462:33-7. 2015
    In previous studies, we demonstrated that down-regulation of lipoprotein lipase in L6 muscle cells increased insulin-stimulated glucose uptake...
  11. pmc The tissue distribution of lipoprotein lipase determines where chylomicrons bind
    Roger Savonen
    Department of Medical Biosciences, Physiological Chemistry, Umea University, Umea, Sweden
    J Lipid Res 56:588-98. 2015
    To determine the role of LPL for binding of lipoproteins to the vascular endothelium, and for the distribution of lipids from lipoproteins, four lines of induced mutant mice were used...
  12. pmc Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissue
    Olessia Kroupa
    Department of Medical Biosciences Physiological Chemistry, Umea University, Umeå SE 90187, Sweden
    BMC Physiol 12:13. 2012
    b>Lipoprotein lipase (LPL) hydrolyzes triglycerides in lipoproteins and makes fatty acids available for tissue metabolism. The activity of the enzyme is modulated in a tissue specific manner by interaction with other proteins...
  13. doi Hyperglycemia-induced secretion of endothelial heparanase stimulates a vascular endothelial growth factor autocrine network in cardiomyocytes that promotes recruitment of lipoprotein lipase
    Dahai Zhang
    From the Faculty of Pharmaceutical Sciences D Z, A W, A P L C, Y W, F W, K N, N L, B R, and Department of Cellular and Physiological Sciences M J B, J D J, University of British Columbia, Canada and Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Israel I V
    Arterioscler Thromb Vasc Biol 33:2830-8. 2013
    During diabetes mellitus, coronary lipoprotein lipase increases to promote the predominant use of fatty acids...
  14. doi Cardiomyocyte VEGF Regulates Endothelial Cell GPIHBP1 to Relocate Lipoprotein Lipase to the Coronary Lumen During Diabetes Mellitus
    Amy Pei Ling Chiu
    From the Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada A P L C, A W, N L, D Z, F W, B H, B R and Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel I V
    Arterioscler Thromb Vasc Biol 36:145-55. 2016
    b>Lipoprotein lipase (LPL)-mediated triglyceride hydrolysis is the major source of fatty acid for cardiac energy...
  15. pmc Activated cyclin-dependent kinase 5 promotes microglial phagocytosis of fibrillar β-amyloid by up-regulating lipoprotein lipase expression
    Yuanhui Ma
    State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China
    Mol Cell Proteomics 12:2833-44. 2013
    ..Bioinformatic analysis revealed strong over-representation of membrane proteins, including lipoprotein lipase (LPL), among proteins regulated by the Aβ stimulus...
  16. pmc Lipoprotein lipase deficiency in chronic kidney disease is accompanied by down-regulation of endothelial GPIHBP1 expression
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Irvine, CA, USA
    Clin Exp Nephrol 16:238-43. 2012
    ..and impaired clearance of very low density lipoprotein (VLDL) and chylomicrons which are largely due to lipoprotein lipase (LPL) deficiency/dysfunction...
  17. doi Endothelial heparanase regulates heart metabolism by stimulating lipoprotein lipase secretion from cardiomyocytes
    Ying Wang
    Faculty of Pharmaceutical Sciences, The University of British Columbia, 2405 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 1Z3
    Arterioscler Thromb Vasc Biol 33:894-902. 2013
    After diabetes mellitus, transfer of lipoprotein lipase (LPL) from cardiomyocytes to the coronary lumen increases, and this requires liberation of LPL from the myocyte surface heparan sulfate proteoglycans with subsequent replenishment of ..
  18. ncbi Association of lipoprotein lipase S447X, apolipoprotein E exon 4, and apoC3 -455T>C polymorphisms on the susceptibility to diabetic nephropathy
    M C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Genet 70:20-8. 2006
    ..In DN patients, triglyceride (TG) level is elevated and lipoprotein lipase (LPL) activity, which hydrolyzes TG, is decreased...
  19. ncbi Protein restriction and AST-120 improve lipoprotein lipase and VLDL receptor in focal glomerulosclerosis
    Tadashi Sato
    Department of Pediatrics, Saga Medical School, Saga City, Japan
    Kidney Int 64:1780-6. 2003
    ..Recently, we reported marked down-regulations of skeletal muscle and adipose tissue lipoprotein lipase (LPL) and very low-density lipoprotein (VLDL) receptor in male Imai rats at 32 weeks of age...
  20. doi Simplified analysis of lipoprotein lipase activity: evaluation of lipasemic activity of low molecular weight heparin in rats
    Jun Pil Jee
    College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Arch Pharm Res 35:1107-14. 2012
    A simple procedure for measuring lipoprotein lipase activity was developed by using newly formulated substrate with turbidimetry method...
  21. pmc Cardiac lipoprotein lipase activity in the hypertrophied heart may be regulated by fatty acid flux
    David Hauton
    School of Clinical and Experimental Medicine, College of Medicinal and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
    Biochim Biophys Acta 1821:627-36. 2012
    ..It is unclear whether uptake mechanisms such as lipoprotein lipase (LPL) can be attenuated to diminish this uptake...
  22. ncbi Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes. A role for a protein kinase B, LKB1, and AMP-activated protein kinase cascade
    Su Jin Kim
    Department of Cellular and Physiological Sciences, The Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 282:8557-67. 2007
    ..and the present study was directed at identifying the mechanisms underlying its stimulatory action on lipoprotein lipase (LPL)...
  23. ncbi Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes
    Su Jin Kim
    Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Biol Chem 282:34139-47. 2007
    ..In previous studies on the stimulatory effect of GIP on adipocyte lipoprotein lipase (LPL), a pathway was identified involving increased phosphorylation of protein kinase B (PKB) and reduced ..
  24. ncbi Apolipoprotein E and lipoprotein lipase gene polymorphisms interaction on the atherogenic combined expression of hypertriglyceridemia and hyperapobetalipoproteinemia phenotypes
    P Perron
    Department of Medicine, University of Montreal, University of Montreal Community Genomic Medicine Center and Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Quebec, Canada G7H5H6
    J Endocrinol Invest 30:551-7. 2007
    ..Apolipoprotein (apo) E and lipoprotein lipase (LPL) genes are involved in the catabolism of triglycerides (TG)-rich apoB-containing lipoproteins (VLDL)...
  25. doi Postprandial chylomicrons and adipose tissue lipoprotein lipase are altered in type 2 diabetes independently of obesity and whole-body insulin resistance
    Giovanni Annuzzi
    Department of Clinical and Experimental Medicine, Federico II University, Via Pansini 5, 80131 Naples, Italy
    Nutr Metab Cardiovasc Dis 18:531-8. 2008
    ..The aim of this study is to differentiate the effects of whole-body insulin resistance, obesity, and type 2 diabetes on postprandial dyslipidaemia and lipoprotein lipase (LPL) in adipose tissue.
  26. ncbi [Gene expression of hormone sensitive lipase and lipoprotein lipase in obesity-prone and obesity-resistant rats induced by high-fat diet]
    Weiwei Ma
    Department of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin 150081, China
    Wei Sheng Yan Jiu 36:320-2. 2007
    To explore the gene expression of hormone sensitive lipase (HSL) and lipoprotein lipase (LPL) between obesity-prone (OP) and obesity-resistant (OR) rats induced by a high-fat diet.
  27. ncbi Oxidized fat reduces milk triacylglycerol concentrations by inhibiting gene expression of lipoprotein lipase and fatty acid transporters in the mammary gland of rats
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University, D 06108 Halle Saale, Germany
    J Nutr 137:2056-61. 2007
    ..of triacylglycerols and nonesterified fatty acids (NEFA) in plasma and lower mRNA concentrations of lipoprotein lipase and fatty acid transporters in the mammary gland than the FF group (P < 0.05)...
  28. doi Metabolism of very-low-density lipoprotein and chylomicrons by streptozotocin-induced diabetic rat heart: effects of diabetes and lipoprotein preference
    You Guo Niu
    Department of Clinical Aerospace Medicine, The Fourth Military Medical University, Xi an, China
    Am J Physiol Endocrinol Metab 295:E1106-16. 2008
    ..Heparin-releasable lipoprotein lipase (HR-LPL) activity was increased in STZ-induced diabetic hearts, but tissue residual LPL activity was ..
  29. doi Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes: the genetics, outcomes, and lipids in type 2 diabetes (GOLD) study
    Maria C Izar
    Cardiology Division, Department of Medicine, Rua Pedro de Toledo 276, Sao Paulo, SP, Brazil
    Atherosclerosis 204:165-70. 2009
    ..APO A1 (A/G -75 and C/T +83) and APO C3 (C/G 3'UTR) non-coding sequences, CETP (Taq 1B), LPL (D9N), APO E (epsilon2, epsilon3, epsilon4,), PON-1 (Q192R), and two LCAT variants Arg(147)-->Trp and Tyr(171)--&..
  30. pmc Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues
    Hong Wang
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA
    Diabetes 58:116-24. 2009
    Skeletal muscle-specific LPL knockout mouse (SMLPL(-/-)) were created to study the systemic impact of reduced lipoprotein lipid delivery in skeletal muscle on insulin sensitivity, body weight, and composition.
  31. pmc Association of lipoprotein lipase (LPL) single nucleotide polymorphisms with type 2 diabetes mellitus
    Yoon Shin Cho
    National Genome Research Institute, National Institute of Health, Seoul 122 701, Korea
    Exp Mol Med 40:523-32. 2008
    ..b>Lipoprotein lipase (LPL) is a key enzyme in human lipid metabolism that facilitates the removal of triglyceride-rich ..
  32. doi Nitric oxide and the release of lipoprotein lipase from white adipose tissue
    David Ricart-Jané
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Cell Physiol Biochem 22:525-30. 2008
    b>Lipoprotein lipase (LPL) is the main enzyme responsible for the distribution of circulating triacylglycerides in tissues. Its regulation via release from active sites in the vascular endothelium is poorly understood...
  33. ncbi [Lipoprotein lipase expression in the hippocampus and its effects on vitamin E levels in rats with epilepsy]
    Xuan Shi
    Department of Pediatrics, People s Hospital of Wuhan University, Wuhan, China
    Zhongguo Dang Dai Er Ke Za Zhi 12:377-81. 2010
    To investigate the dynamic changes of lipoprotein lipase (LPL) expression in the hippocampus of epileptic rats and to study its effect on vitamin E levels in rats following status epilepticus (SE).
  34. doi Adiponectin increases LPL activity via RhoA/ROCK-mediated actin remodelling in adult rat cardiomyocytes
    Riya Ganguly
    Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3
    Endocrinology 152:247-54. 2011
    ..Here we investigated mechanisms whereby adiponectin mediates a particular metabolic effect by focusing on lipoprotein lipase (LPL), an enzyme that increases free fatty acid availability to the heart by breakdown of chylomicrons and ..
  35. pmc Severity of diabetes governs vascular lipoprotein lipase by affecting enzyme dimerization and disassembly
    Ying Wang
    Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada
    Diabetes 60:2041-50. 2011
    ..FA provided to the heart comes from the breakdown of circulating triglyceride (TG), a process catalyzed by lipoprotein lipase (LPL) located at the vascular lumen...
  36. ncbi PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion
    Mathieu Laplante
    Department of Anatomy and Physiology, Laval Hospital Research Center, School of Medicine, Laval University, Quebec, Canada
    Diabetes 52:291-9. 2003
    ..proliferator-activated receptor-gamma (PPAR-gamma) agonists on fat deposition extends to the expression of lipoprotein lipase (LPL) and other key adipose lipid metabolism genes, and whether changes in LPL impact triglyceridemia...
  37. ncbi [Lipoprotein lipase deficiencies]
    J Etienne
    Laboratoire de Biochimie et Biologie Moleculaire, CHU St Antoine Tenon, Faculte de Medecine, Paris, France
    Ann Biol Clin (Paris) 50:299-309. 1992
    b>Lipoprotein lipase (LPL) is an enzyme which plays a major role in the metabolism of circulating triglyceride-rich lipoproteins...
  38. ncbi Catalytic triad residue mutation (Asp156----Gly) causing familial lipoprotein lipase deficiency. Co-inheritance with a nonsense mutation (Ser447----Ter) in a Turkish family
    F Faustinella
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 266:14418-24. 1991
    ..of Turkish descent who had normal plasma apolipoprotein C-II levels and undetectable plasma post-heparin lipoprotein lipase (LPL) activity...
  39. ncbi Lipoprotein lipase gene expression in rat adipocytes is regulated by isoproterenol and insulin through different mechanisms
    M V Raynolds
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262
    Mol Endocrinol 4:1416-22. 1990
    b>Lipoprotein lipase (LPL) is highly regulated by catecholamines and insulin in adipocytes. Isoproterenol, a beta-adrenergic agonist, decreases LPL enzyme activity, whereas insulin increases LPL activity...
  40. pmc Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice
    S Levak-Frank
    Institute of Medical Biochemistry, Karl Franzens University, Graz, Austria
    J Clin Invest 96:976-86. 1995
    In extrahepatic tissues lipoprotein lipase (LPL) hydrolyzes triglycerides thereby generating FFA for tissue uptake and metabolism...
  41. ncbi Common DNA polymorphisms at the lipoprotein lipase gene. Association with severity of coronary artery disease and diabetes
    X L Wang
    Department of Cardiovascular Medicine, University of New South Wales, Prince Henry Prince of Wales Hospitals, Sydney, Australia
    Circulation 93:1339-45. 1996
    DNA variants of the lipoprotein lipase gene are associated with changes in lipid metabolism similar to those in diabetes and may relate to the development of atherosclerotic lesions, particularly premature lesions.
  42. ncbi Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia
    K A Scribner
    Shaman Pharmaceuticals, South San Francisco, CA 94080 4812, USA
    Metabolism 49:1106-10. 2000
    ..05). In addition adipose tissue lipoprotein lipase (LPL) activity was increased in masoprocol-treated rats and adipose tissue hormone-sensitive lipase (HSL) ..
  43. ncbi Resistance of adipose tissue lipoprotein lipase to insulin action in rats fed an obesity-promoting diet
    Frederic Picard
    Centre de Recherche de l Hôpital Laval et Centre de Recherche sur le Métabolisme Energétique, Département d anatomie et physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Am J Physiol Endocrinol Metab 282:E412-8. 2002
    This study aimed to assess whether adipose lipoprotein lipase (LPL) becomes resistant to insulin in a nutritional model of resistance of glucose metabolism to insulin...
  44. ncbi Effect of diet on adipose tissue and skeletal muscle VLDL receptor and LPL: implications for obesity and hyperlipidemia
    Christian K Roberts
    Department of Physiological Science, UCLA, University of California, PO Box 951606, Los Angeles, CA 90095 1606, USA
    Atherosclerosis 161:133-41. 2002
    ..diet (HFS), which is known to induce obesity and hyperlipidemia, on adipose tissue and skeletal muscle lipoprotein lipase (LPL) and very-low density lipoprotein receptor (VLDL-R) protein expressions...
  45. ncbi Developmental changes in adipose and muscle lipoprotein lipase activity in the atherosclerosis-prone JCR:LA-corpulent rat
    L Mantha
    Centre de recherche sur le métabolisme énergétique, Département d anatomie et physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Int J Obes Relat Metab Disord 26:308-17. 2002
    To characterize the developmental changes in adipose and muscle lipoprotein lipase (LPL) activity in the atherosclerosis-prone JCR:LA-corpulent rat, and to test the hypothesis that tissue-specific abnormalities in LPL activity precede the ..
  46. ncbi Sciatic nerve lipoprotein lipase is reduced in streptozotocin-induced diabetes and corrected by insulin
    L D M C B Ferreira
    University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Endocrinology 143:1213-7. 2002
    The metabolic abnormalities underlying the cause of diabetic neuropathy have been the subject of much debate. Lipoprotein lipase (LPL) is a 56-kDa enzyme produced by several tissues in the body and has recently been shown in vitro to be ..
  47. pmc Streptozotocin-induced diabetes decreases mammary gland lipoprotein lipase activity and messenger ribonucleic acid in pregnant and nonpregnant rats
    Laura Blanco-Dolado
    Servicio de Bioquímica Investigación, Hospital Ramon y Cajal, Madrid, Spain
    Int J Exp Diabetes Res 3:61-8. 2002
    Diabetes mellitus is associated with a reduction of lipoprotein lipase (LPL) activity in adipose tissue and development of hypertriglyceridemia...
  48. ncbi The hormonal responses of lipoprotein lipase activity and lipolysis in adipose tissue differ depending on the stage of the estrous cycle in female rats
    M Yamaguchi
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu, Onsen gun, Ehime, Japan
    Int J Obes Relat Metab Disord 26:610-7. 2002
    ....
  49. ncbi Apolipoprotein E and lipoprotein lipase increase triglyceride-rich particle binding but decrease particle penetration in arterial wall
    Adam E Mullick
    Division of Endocrinology, University of California, Davis 95616, USA
    Arterioscler Thromb Vasc Biol 22:2080-5. 2002
    ..We evaluated the effects of apoE and lipoprotein lipase (LpL) on the interactions of triglyceride-rich particles (TGRPs) in the arterial wall.
  50. ncbi Lipoprotein lipase: structure, function, regulation, and role in disease
    James R Mead
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, UK
    J Mol Med (Berl) 80:753-69. 2002
    b>Lipoprotein lipase (LPL) catalyses the hydrolysis of the triacylglycerol component of circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified fatty acids and 2-monoacylglycerol for tissue utilisation...
  51. ncbi Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats
    Takahiro Shimizu
    Department of Pharmacology, Graduate School of Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    Eur J Pharmacol 571:138-44. 2007
    ..c.v.) had no effect. These results suggest the involvement of brain phosphatidylinositol-specific PLC and diacylglycerol lipase in the centrally administered histamine-induced activation of the adrenomedullary outflow in rats...
  52. pmc Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low-intensity activity
    Lionel Bey
    Department of Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri Columbia, MO, USA
    J Physiol 551:673-82. 2003
    We have examined the regulation of lipoprotein lipase (LPL) activity in skeletal muscle during physical inactivity in comparison to low-intensity contractile activity of ambulatory controls...
  53. ncbi Evidence for rapid "metabolic switching" through lipoprotein lipase occupation of endothelial-binding sites
    Thomas Pulinilkunnil
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, British Columbia, Canada V6T 1Z3
    J Mol Cell Cardiol 35:1093-103. 2003
    ..In the current study, we examined the contribution of cardiac lipoprotein lipase (LPL) towards providing FA to the diabetic heart...
  54. ncbi The metabolic "switch" AMPK regulates cardiac heparin-releasable lipoprotein lipase
    Ding An
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Endocrinol Metab 288:E246-53. 2005
    ..Given the importance of lipoprotein lipase (LPL) in providing hearts with fatty acids (FA), the preferred substrate consumed by the heart, the ..
  55. pmc Extracellular degradation of lipoprotein lipase in rat adipose tissue
    Gengshu Wu
    Department of Medical Biosciences, Physiological Chemistry, Umea University, SE 90187 Umea, Sweden
    BMC Cell Biol 6:4. 2005
    Recent studies in vivo indicate that short-term regulation of lipoprotein lipase (LPL) in rat adipose tissue is post-translational and occurs by a shift of the lipase protein towards an inactive form under the influence of another gene ..
  56. ncbi Lysophosphatidic acid-mediated augmentation of cardiomyocyte lipoprotein lipase involves actin cytoskeleton reorganization
    Thomas Pulinilkunnil
    Div of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The Univ of British Columbia, 2146 East Mall, Vancouver, British Columbia, Canada
    Am J Physiol Heart Circ Physiol 288:H2802-10. 2005
    The lipoprotein lipase (LPL)-augmenting property of lysophosphatidylcholine requires the formation of lysophosphatidic acid (LPA) (J Mol Cell Cardiol 37: 931-938, 2004)...
  57. ncbi Changes in lipoprotein lipase modulate tissue energy supply during stress
    David Ricart-Jané
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    J Appl Physiol (1985) 99:1343-51. 2005
    We studied the variations caused by stress in lipoprotein lipase (LPL) activity, LPL-mRNA, and local blood flow in LPL-rich tissues in the rat...
  58. ncbi Lipoprotein lipase gene is linked and associated with hypertension in Taiwan young-onset hypertension genetic study
    Pei Chen
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    J Biomed Sci 12:651-8. 2005
    ..However, the mechanism behind it is poorly understood. A positive linkage signal between Lipoprotein lipase (LPL) and young-onset hypertension has been identified by us as the strongest among 18 candidate genes...
  59. ncbi A novel substitution at the translation initiator codon (ATG-->ATC) of the lipoprotein lipase gene is mainly responsible for lipoprotein lipase deficiency in a patient with severe hypertriglyceridemia and recurrent pancreatitis
    Xue Hui Yu
    Department of Pathophysiology, School of Medicine, Shandong University, Jinan, PR China
    Biochem Biophys Res Commun 341:82-7. 2006
    ..with severe hypertriglyceridemia and recurrent pancreatitis was found to have significantly decreased lipoprotein lipase (LPL) activity and normal apolipoprotein C-II concentration in post-heparin plasma...
  60. ncbi Endothelial bound lipoprotein lipase (LpL) depletion in hypoalbuminemia results from decreased endothelial binding, not decreased secretion
    G C Shearer
    Department of Veterans Affairs Northern California Health Care System, Mather, California 95616, USA
    Kidney Int 70:647-53. 2006
    ..The heparin releasable lipoprotein lipase (LpL) pool in both models is greatly reduced, suggesting reduced LpL is related to low albumin or pi and not ..
  61. ncbi Involvement of adipose tissues in the early hypolipidemic action of PPARgamma agonism in the rat
    Mathieu Laplante
    Laval Hospital Research Center, Laval Hospital d Youville Y3110, 2725 Chemin Sainte Foy, Quebec, QC, Canada, G1V 4G5
    Am J Physiol Regul Integr Comp Physiol 292:R1408-17. 2007
    ..Accelerated TG clearance was associated with increased lipoprotein lipase (LPL) activity mostly in BAT...
  62. ncbi Sequence of rat lipoprotein lipase-encoding cDNA
    D Brault
    Laboratoire de Biochimie et Biologie Moleculaire, Faculté de médecine St Antoine, Paris, France
    Gene 121:237-46. 1992
    A rat lipoprotein lipase (LPL)-encoding cDNA (LPL) has been entirely sequenced and compared to the sequences of all the LPL cDNAs reported in other species. As expected, high homology was found between the coding exons...
  63. ncbi Retroperitoneal white adipose tissue lipoprotein lipase activity is rapidly down-regulated in response to acute stress
    Albert Casanovas
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    J Lipid Res 48:863-8. 2007
    Tissue-specific regulation of LPL has been widely studied in rats...
  64. ncbi Relationship between lipoprotein lipase and peroxisome proliferator-activated receptor-alpha expression in rat liver during development
    M Panadero
    Facultad de Farmacia, Universidad San Pablo CEU, E 28668 Boadilla del Monte, Madrid, Spain
    J Physiol Biochem 62:189-98. 2006
    ..receptor-alpha (PPAR-alpha) in rat liver during the perinatal stage plays a role in the induction of liver lipoprotein lipase (LPL) expression and activity...