Ldha

Summary

Gene Symbol: Ldha
Description: lactate dehydrogenase A
Alias: CDK1, Ldh1, L-lactate dehydrogenase A chain, LDH muscle subunit, LDH-A, LDH-M, lactate dehydrogenase A-like
Species: rat

Top Publications

  1. doi Lactate dehydrogenase regulation in aged skeletal muscle: Regulation by anabolic steroids and functional overload
    Tyrone A Washington
    Exercise Muscle Biology Laboratory, Human Performance Laboratory, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville AR 72701, United States Integrative Muscle Biology Laboratory, Exercise Science Department, Norman J Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, United States Electronic address
    Exp Gerontol 57:66-74. 2014
  2. pmc Lactate dehydrogenase a expression is necessary to sustain rapid angiogenesis of pulmonary microvascular endothelium
    Glenda Parra-Bonilla
    Department of Pharmacology, University of South Alabama, Mobile, Alabama, United States of America Center for Lung Biology, University of South Alabama, Mobile, Alabama, United States of America
    PLoS ONE 8:e75984. 2013
  3. ncbi Isolation of diabetes-associated kidney genes using differential display
    R Page
    Division of Life Sciences, Kings College London, United Kingdom
    Biochem Biophys Res Commun 232:49-53. 1997
  4. ncbi Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes
    D Ross Laybutt
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 278:2997-3005. 2003
  5. ncbi Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer
    Wen Lee Tan
    Cancer Science Institute of Singapore, Center for Life Sciences, National University of Singapore, Singapore
    Cancer Biol Ther 11:599-608. 2011
  6. doi Identification and physiological activity of survival factor released from cardiomyocytes during ischaemia and reperfusion
    Yoichi Mizukami
    Center for Gene Research, Yamaguchi University, Yamaguchi 755 8505, Japan
    Cardiovasc Res 79:589-99. 2008
  7. ncbi M-LDH serves as a regulatory subunit of the cytosolic substrate-channelling complex in vivo
    Sofija Jovanovic
    Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, UK
    J Mol Biol 371:349-61. 2007
  8. ncbi Effect of anabolic steroid nandrolone decanoate on the properties of certain enzymes in the heart, liver, and muscle of rats, and their effect on rats' cardiac electrophysiology
    A Tylicki
    Department of Animal Biochemistry, University of Bialystok, Ul Swierkowa 20B, Białystok, Poland
    Horm Metab Res 39:268-72. 2007
  9. pmc Identification of estrogen-regulated genes by microarray analysis of the uterus of immature rats exposed to endocrine disrupting chemicals
    Eui Ju Hong
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 361 763, Republic of Korea
    Reprod Biol Endocrinol 4:49. 2006
  10. ncbi Identification of mono-ubiquitinated LDH-A in skeletal muscle cells exposed to oxidative stress
    Yuko Onishi
    Department of Nutrition, The University of Tokushima School of Medicine, Tokushima 770 8503, Japan
    Biochem Biophys Res Commun 336:799-806. 2005

Scientific Experts

  • Tyrone A Washington
  • J C Jonas
  • Yoichi Mizukami
  • Adam Tylicki
  • Richard A Jungmann
  • Eui Ju Hong
  • Elisabeth Deindl
  • Glenda Parra-Bonilla
  • Wen Lee Tan
  • Sofija Jovanovic
  • Yuko Onishi
  • I P Lopez
  • B C Lewis
  • D Ross Laybutt
  • H Shim
  • Audrey Vasauskas
  • Mikhail Alexeyev
  • Diego F Alvarez
  • Troy Stevens
  • C E Peters
  • Richie Soong
  • Mohamed Akram
  • Iduna Fichtner
  • Limsoon Wong
  • Marie Loh
  • Bhavin Thakkar
  • Manuel Salto-Tellez
  • Bhaskar Bhattacharya
  • Difeng Dong
  • Ross A Soo
  • Barry Iacopetta
  • Indirikumar Balasubramanian
  • C V Dang
  • Russell M Crawford
  • Aleksandar Jovanovic
  • Harumi Furochi
  • Shunji Nakano
  • Kyoichi Kishi
  • Jumpei Goto
  • Takeshi Nikawa
  • Naoto Suzue
  • Takayuki Ogawa
  • Motoko Oarada
  • Katsuya Hirasaka
  • Kazumi Ishidoh
  • Ibuki Ishihara
  • R Page
  • F I Milagro
  • C de Miguel
  • A Marti
  • J A Martinez
  • M J Moreno-Aliaga
  • Yu Bai Ahn
  • Susan Bonner-Weir
  • Nitin Trivedi
  • Mariela Glandt
  • Gordon C Weir
  • Gang Xu
  • A W Gelb
  • J X Wilson
  • J Korcok
  • D Huang
  • S E Campbell
  • J E Prescott
  • R Z Orlowski
  • Y S Chun
  • A N Malik
  • C Morris
  • J Williams
  • C von Ruhland
  • T J Beebee
  • K R Williams
  • L M Matrisian
  • D S Carty
  • G L Patel
  • G Rautmann
  • B E Magun
  • R Breathnach
  • S Reddigari

Detail Information

Publications23

  1. doi Lactate dehydrogenase regulation in aged skeletal muscle: Regulation by anabolic steroids and functional overload
    Tyrone A Washington
    Exercise Muscle Biology Laboratory, Human Performance Laboratory, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville AR 72701, United States Integrative Muscle Biology Laboratory, Exercise Science Department, Norman J Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, United States Electronic address
    Exp Gerontol 57:66-74. 2014
    ..Our study provides evidence that aging alters aspects of skeletal muscle metabolic plasticity normally induced by overload and anabolic steroid administration. ..
  2. pmc Lactate dehydrogenase a expression is necessary to sustain rapid angiogenesis of pulmonary microvascular endothelium
    Glenda Parra-Bonilla
    Department of Pharmacology, University of South Alabama, Mobile, Alabama, United States of America Center for Lung Biology, University of South Alabama, Mobile, Alabama, United States of America
    PLoS ONE 8:e75984. 2013
    ..These findings demonstrate that LDH-A is critically important for sustaining the rapid angiogenesis of pulmonary microvascular endothelial cells. ..
  3. ncbi Isolation of diabetes-associated kidney genes using differential display
    R Page
    Division of Life Sciences, Kings College London, United Kingdom
    Biochem Biophys Res Commun 232:49-53. 1997
    ..Eight candidate diabetes-associated cDNA fragments, CDK1-8, were isolated and characterised...
  4. ncbi Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes
    D Ross Laybutt
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 278:2997-3005. 2003
    ..Thus, both the severity and duration of hyperglycemia appear to contribute to the deterioration of the beta-cell phenotype found in diabetes...
  5. ncbi Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer
    Wen Lee Tan
    Cancer Science Institute of Singapore, Center for Life Sciences, National University of Singapore, Singapore
    Cancer Biol Ther 11:599-608. 2011
    ..Patients with low CTPS2 did not gain a survival benefit from 5FU treatment (p=0.072), while those with high expression did (p=0.003). Low CTPS2 expression may be a rationally-based determinant of 5FU resistance...
  6. doi Identification and physiological activity of survival factor released from cardiomyocytes during ischaemia and reperfusion
    Yoichi Mizukami
    Center for Gene Research, Yamaguchi University, Yamaguchi 755 8505, Japan
    Cardiovasc Res 79:589-99. 2008
    ....
  7. ncbi M-LDH serves as a regulatory subunit of the cytosolic substrate-channelling complex in vivo
    Sofija Jovanovic
    Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, UK
    J Mol Biol 371:349-61. 2007
    ....
  8. ncbi Effect of anabolic steroid nandrolone decanoate on the properties of certain enzymes in the heart, liver, and muscle of rats, and their effect on rats' cardiac electrophysiology
    A Tylicki
    Department of Animal Biochemistry, University of Bialystok, Ul Swierkowa 20B, Białystok, Poland
    Horm Metab Res 39:268-72. 2007
    ..On the other hand, ND may cause activation of ATP synthesis in muscle by enhanced malate-aspartate shuttle action...
  9. pmc Identification of estrogen-regulated genes by microarray analysis of the uterus of immature rats exposed to endocrine disrupting chemicals
    Eui Ju Hong
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 361 763, Republic of Korea
    Reprod Biol Endocrinol 4:49. 2006
    ....
  10. ncbi Identification of mono-ubiquitinated LDH-A in skeletal muscle cells exposed to oxidative stress
    Yuko Onishi
    Department of Nutrition, The University of Tokushima School of Medicine, Tokushima 770 8503, Japan
    Biochem Biophys Res Commun 336:799-806. 2005
    ..Our results suggest that oxidative stress induces not only poly-ubiquitination but also mono-ubiquitination of LDH-A, which may be involved in its lysosomal degradation during unloading...
  11. ncbi Cyclic AMP and AKAP-mediated targeting of protein kinase A regulates lactate dehydrogenase subunit A mRNA stability
    Richard A Jungmann
    Department of Cellular and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    J Biol Chem 280:25170-7. 2005
    ....
  12. ncbi Gene expression changes in rat white adipose tissue after a high-fat diet determined by differential display
    I P Lopez
    Department of Biochemistry and Molecular Biology, University of Navarra, 31080 Pamplona, Navarra, Spain
    Biochem Biophys Res Commun 318:234-9. 2004
    ....
  13. ncbi Effect of intermittent high altitude hypoxia on gene expression in rat heart and lung
    E Deindl
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, W G Kerckhoff Institute, Bad Nauheim, Germany
    Physiol Res 52:147-57. 2003
    ..It differently regulates the expression of distinct genes not only in individual organs but even within one organ, i.e. in the heart...
  14. pmc Identification of a nucleic acid helix-destabilizing protein from rat liver as lactate dehydrogenase-5
    K R Williams
    Proc Natl Acad Sci U S A 82:5260-4. 1985
    ..These results indicate caution in ascribing in vivo roles solely on the basis of binding to ss DNA. Alternatively, they suggest that a single protein may play more than one biological role...
  15. ncbi High glucose stimulates early response gene c-Myc expression in rat pancreatic beta cells
    J C Jonas
    Unit of Endocrinology and Metabolism, University of Louvain, Brussels, Belgium
    J Biol Chem 276:35375-81. 2001
    ..c-Myc could therefore participate to the regulation of beta cell growth, apoptosis, and differentiation under physiological or pathophysiological conditions...
  16. ncbi Anesthetic concentrations of propofol protect against oxidative stress in primary astrocyte cultures: comparison with hypothermia
    C E Peters
    Department of Physiology, University of Western Ontario, London, Canada
    Anesthesiology 94:313-21. 2001
    ..This increase may be caused, in part, by changes in glutamate transport by astrocytes. The authors hypothesized that propofol and hypothermia mitigate the effects on astrocytes of oxidative stress...
  17. ncbi Tumor induction by the c-Myc target genes rcl and lactate dehydrogenase A
    B C Lewis
    Program in Human Genetics and Molecular Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 60:6178-83. 2000
    ..These findings confirm Rcl and LDH-A as critical components of the cell transformation program induced by c-Myc and suggest that Rcl is tumorigenic in cells that are provided with a permissive metabolic milieu...
  18. pmc A unique glucose-dependent apoptotic pathway induced by c-Myc
    H Shim
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:1511-6. 1998
    ..These studies provide insights on the coupling of glucose metabolism and the cell cycle in c-Myc-transformed cells and may in the future be exploited for cancer therapeutics...
  19. ncbi Transcriptional regulation of the lactate dehydrogenase A subunit gene by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate
    D Huang
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    Mol Cell Endocrinol 108:87-94. 1995
    ..1.1.27) isozymes occurs through a multitude of physiological signals. Here, we show that modulation of LDH A subunit occurs via the protein kinase C pathway...
  20. pmc Purification and radioimmunoassay of rat lactate dehydrogenase A and B subunits
    T J Beebee
    Biochem J 205:313-20. 1982
    ..The radioimmunoassays provide a sensitive method for measuring nanogram amounts of A-subunit and B-subunit polypeptides in tissue homogenates and were employed to characterize the enzyme purification procedures...
  21. ncbi A study of lactate dehydrogenase levels and turnover rates during postnatal development in the rat
    T J Beebee
    Biochim Biophys Acta 757:209-18. 1983
    ....
  22. ncbi Cyclic AMP regulation of lactate dehydrogenase. Isoproterenol and N6,O2-dibutyryl cyclic amp increase the rate of transcription and change the stability of lactate dehydrogenase a subunit messenger RNA in rat C6 glioma cells
    R A Jungmann
    J Biol Chem 258:5312-8. 1983
    ..5 h. These results indicate that both isoproterenol and dibutyrl cAMP regulate not only the rate of transcription of mRNALDH but that the stability of mRNALDH is increased during the induction phase...
  23. pmc Epidermal growth factor or serum stimulation of rat fibroblasts induces an elevation in mRNA levels for lactate dehydrogenase and other glycolytic enzymes
    L M Matrisian
    Nucleic Acids Res 13:711-26. 1985
    ..The complete nucleotide sequence of a rat fibroblast lactate dehydrogenase is presented...