Kir5 1

Summary

Gene Symbol: Kir5 1
Description: potassium voltage-gated channel subfamily J member 16
Alias: Kir5.1, inward rectifier potassium channel 16, BIR9, inward rectifier K(+) channel Kir5.1, potassium channel, inwardly rectifying subfamily J member 16, potassium inwardly-rectifying channel, subfamily J, member 16
Species: rat

Top Publications

  1. pmc In vivo formation of a proton-sensitive K+ channel by heteromeric subunit assembly of Kir5.1 with Kir4.1
    M Tanemoto
    Department of Pharmacology II, Graduate School of Medicine, Osaka University, Yamada oka 2 2, Suita, Osaka 565 0871, Japan
    J Physiol 525:587-92. 2000
  2. ncbi Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels
    Angelos Aristeidis Konstas
    University Laboratory of Physiology, Oxford, OX1 3PT, United Kingdom
    Am J Physiol Cell Physiol 284:C910-7. 2003
  3. ncbi pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia
    S J Tucker
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, United Kingdom
    J Biol Chem 275:16404-7. 2000
  4. ncbi Expression of an inwardly rectifying K+ channel, Kir5.1, in specific types of fibrocytes in the cochlear lateral wall suggests its functional importance in the establishment of endocochlear potential
    Hiroshi Hibino
    Department of Pharmacology II, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Eur J Neurosci 19:76-84. 2004
  5. pmc Astrocytes in the retrotrapezoid nucleus sense H+ by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism
    Ian C Wenker
    University of Connecticut, Department of Physiology and Neurobiology, 75 N Eagleville Rd, Storrs, CT 06269, USA
    J Neurophysiol 104:3042-52. 2010
  6. pmc Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis
    Lijun Shang
    Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, United Kingdom
    Biochem Biophys Res Commun 388:501-5. 2009
  7. ncbi Cloning and expression of a family of inward rectifier potassium channels
    C T Bond
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Receptors Channels 2:183-91. 1994
  8. ncbi PDZ binding motif-dependent localization of K+ channel on the basolateral side in distal tubules
    Masayuki Tanemoto
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    Am J Physiol Renal Physiol 287:F1148-53. 2004
  9. pmc Novel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces
    Ke Dong
    Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT, USA
    EMBO J 24:1318-29. 2005

Scientific Experts

  • Masayuki Tanemoto
  • S J Tucker
  • Ian C Wenker
  • Lijun Shang
  • Ke Dong
  • Hiroshi Hibino
  • Angelos Aristeidis Konstas
  • Daniel K Mulkey
  • Orsolya KrĂ©neisz
  • Akiko Nishiyama
  • Sarah V Ranson
  • Qiang Leng
  • Gordon G MacGregor
  • Lie Qi Tang
  • Steven C Hebert
  • Akikazu Fujita
  • Masaru Ishii
  • Kayoko Higashi-Shingai
  • Yoshihisa Kurachi
  • Kaori Iwai
  • Christoph Korbmacher
  • C T Bond
  • M Pessia
  • A Lagrutta
  • M P Kavanaugh
  • J P Adelman
  • X M Xia

Detail Information

Publications9

  1. pmc In vivo formation of a proton-sensitive K+ channel by heteromeric subunit assembly of Kir5.1 with Kir4.1
    M Tanemoto
    Department of Pharmacology II, Graduate School of Medicine, Osaka University, Yamada oka 2 2, Suita, Osaka 565 0871, Japan
    J Physiol 525:587-92. 2000
    ..1 with Kir4.1 occurs in vivo, at least in kidney. The heteromeric Kir4. 1/Kir5.1 channel may therefore sense intracellular pH in renal epithelium and be involved in the regulation of acid-base homeostasis...
  2. ncbi Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels
    Angelos Aristeidis Konstas
    University Laboratory of Physiology, Oxford, OX1 3PT, United Kingdom
    Am J Physiol Cell Physiol 284:C910-7. 2003
    ....
  3. ncbi pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia
    S J Tucker
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, United Kingdom
    J Biol Chem 275:16404-7. 2000
    ..1 subunit. These findings suggest that Kir5.1/Kir4.1 heteromeric channels are likely to exist in vivo and implicate an important and novel functional role for the Kir5.1 subunit...
  4. ncbi Expression of an inwardly rectifying K+ channel, Kir5.1, in specific types of fibrocytes in the cochlear lateral wall suggests its functional importance in the establishment of endocochlear potential
    Hiroshi Hibino
    Department of Pharmacology II, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Eur J Neurosci 19:76-84. 2004
    ..1 and was correlated with the 'rapid' phase of the elevation of endocochlear potential (EP). Kir5.1 and Kir4.1 channel-subunits may therefore play distinct functional roles in K+ circulation in the cochlear lateral wall...
  5. pmc Astrocytes in the retrotrapezoid nucleus sense H+ by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism
    Ian C Wenker
    University of Connecticut, Department of Physiology and Neurobiology, 75 N Eagleville Rd, Storrs, CT 06269, USA
    J Neurophysiol 104:3042-52. 2010
    ..We conclude that RTN astrocytes sense CO(2)/H(+) in part by inhibition of a Kir4.1-Kir5.1-like current and may provide an excitatory purinergic drive to pH-sensitive neurons...
  6. pmc Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis
    Lijun Shang
    Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, United Kingdom
    Biochem Biophys Res Commun 388:501-5. 2009
    ..These novel channels now provide an excellent model system to determine the structural basis of subconductance levels and contribution of heteromeric pore architecture to this process...
  7. ncbi Cloning and expression of a family of inward rectifier potassium channels
    C T Bond
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Receptors Channels 2:183-91. 1994
    ..The results demonstrate the existence of a large and widely expressed family of inward rectifier potassium channel subunits with distinct tissue distributions and functional properties...
  8. ncbi PDZ binding motif-dependent localization of K+ channel on the basolateral side in distal tubules
    Masayuki Tanemoto
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    Am J Physiol Renal Physiol 287:F1148-53. 2004
    ..1 was responsible for this intracellular localization. These data suggest the signals on the COOH terminus of Kir4.1, including PDZ binding motif, determine the intracellular localization of Kir5.1/Kir4.1 heteromer in distal tubules...
  9. pmc Novel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces
    Ke Dong
    Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT, USA
    EMBO J 24:1318-29. 2005
    ..The short N- and C-terminal segments comprising the novel intermolecular NBS are next to helices that likely move with channel opening/closing, suggesting a lock-and-key model for ligand gating...