Genomes and Genes
Gene Symbol: Kcna2
Description: potassium channel, voltage gated shaker related subfamily A, member 2
Alias: BK2, NGK1, Potassium (K+) channel protein alpha 2, voltage dependent, RAK, RBK2, RCK5, potassium voltage gated channel shaker related subfamily member 2, potassium voltage-gated channel subfamily A member 2, potassium voltage-gated channel, shaker-related subfamily, member 2, voltage-gated potassium channel subunit Kv1.2
- Crystal structure of a mammalian voltage-dependent Shaker family K+ channelStephen B Long
Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Science 309:897-903. 2005..Electrostatic properties of the side portals and positions of the T1 domain and beta subunit are consistent with electrophysiological studies of inactivation gating and with the possibility of K+ channel regulation by the beta subunit...
- Beta subunits promote K+ channel surface expression through effects early in biosynthesisG Shi
Department of Biochemistry and Cell Biology, State University of New York, Stony Brook 11794, USA
Neuron 16:843-52. 1996..These findings provide a molecular basis for recent genetic studies indicating that beta subunits are key determinants of neuronal excitability...
- Contributions of Kv1.2, Kv1.5 and Kv2.1 subunits to the native delayed rectifier K(+) current in rat mesenteric artery smooth muscle cellsYanjie Lu
Department of Physiology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5
Life Sci 71:1465-73. 2002..05). A control antibody (anti-GIRK1) also had no effect on the native Kv currents. This study demonstrates that Kv1.2, Kv1.5, and Kv2.1 subunit genes all contribute to the formation of the native Kv channels in rat mesenteric artery SMCs...
- Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellumMichael R Williams
Neuroscience Graduate Program, Department of Pharmacology, University of Vermont, Burlington, Vermont 05405, USA
J Neurosci 32:9228-37. 2012..2 endocytosis is supported by our finding that infusion into the cerebellar cortex of either the Kv1.2 inhibitor tityustoxin-Kα, or of the Kv1.2 regulator secretin, significantly enhances acquisition of eyeblink conditioning in rats...
- Dynamics of Kv1 channel transport in axonsYuanzheng Gu
Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, Ohio, USA
PLoS ONE 5:e11931. 2010..2 tetramers in axonal puncta. Taken together, our results suggest that proper amounts of Kv1 channels and their associated proteins are required for efficient transport of Kv1 channel proteins along axons...
- Trafficking-dependent phosphorylation of Kv1.2 regulates voltage-gated potassium channel cell surface expressionJae Won Yang
Section of Neurobiology, Physiology, and Behavior, College of Biological Sciences, School of Medicine, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 104:20055-60. 2007..These data support Kv1.2 phosphorylation at these clustered C-terminal sites as playing an important role in regulating trafficking of Kv1.2-containing Kv channels...
- Voltage gated K+ channel expression in arteries of Wistar-Kyoto and spontaneously hypertensive ratsRobert H Cox
Department of Pharmacology, Lankenau Institute for Medical Research, Main Line Health System, Wynnewood, Pennsylvania, USA
Am J Hypertens 21:213-8. 2008..X channel alpha-subunits in arteries from Wistar-Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs). The purpose of this study was to test the hypothesis that these differences are also present at the protein level...
- Atomic constraints between the voltage sensor and the pore domain in a voltage-gated K+ channel of known structureAnthony Lewis
Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
J Gen Physiol 131:549-61. 2008..2 x-ray structure. A structural model is provided for this conformation. The results further highlight the dynamic and flexible nature of the voltage sensor...
- Expression of Kv1.2 in microglia and its putative roles in modulating production of proinflammatory cytokines and reactive oxygen speciesFan Li
Faculty of Basic Medical Sciences, Kunming Medical College, Kunming, China
J Neurochem 106:2093-105. 2008..We conclude that Kv1.2 in microglia modulates IL-1beta and TNF-alpha expression and ROS production probably by regulating the intracellular potassium concentration...
- Clustering and activity tuning of Kv1 channels in myelinated hippocampal axonsChen Gu
Department of Neuroscience and Center for Molecular Neurobiology, Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 286:25835-47. 2011..This effect was eliminated by the Tyr⁴⁵⁸ mutation or by cholesterol depletion. Taken together, our studies suggest that myelin regulates both trafficking and activity of Kv1 channels along hippocampal axons through TAG-1...
- Functional analysis of Kv1.2 and paddle chimera Kv channels in planar lipid bilayersXiao Tao
Howard Hughes Medical Institute, Department of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
J Mol Biol 382:24-33. 2008..2. We find, however, that in several respects, the Kv1.2 channel exhibits functional properties that are distinct from Kv1.2 channels reported in the literature...
- Length-dependent regulation of the Kv1.2 channel activation by its C-terminusLi Li Zhao
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China
Mol Membr Biol 26:186-93. 2009..2 channel. These results imply that the dynamic interaction of the C-terminus with the S4-S5 linker from a neighboring subunit of the Kv1.2 channel provides a mechanism for its C-terminus to regulate the channel activation...
- Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammoniumAhmed Al-Sabi
International Centre for Neurotherapeutics, Dublin City University, Dublin 9, Ireland
J Gen Physiol 136:273-82. 2010..These collective findings indicate that assembly of alpha subunits can be directed by this optimized concatenation, and that subunit arrangement in heteromeric Kv channels affects TEA affinity...
- Regulatory role of the extreme C-terminal end of the S6 inner helix in C-terminal-truncated Kv1.2 channel activationLi Li Zhao
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Cell Biol Int 34:433-9. 2010..Hence, our results indicate that the extreme C-terminal end of the S6 inner helix plays an important regulatory role in the activation of the C-terminal-truncated Kv1.2 channel...
- Principles of conduction and hydrophobic gating in K+ channelsMorten Ø Jensen
DE Shaw Research, New York, NY 10036, USA
Proc Natl Acad Sci U S A 107:5833-8. 2010....
- Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinementXiaorui Chen
Graduate Program of Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 107:11352-7. 2010..2 between the internal and external solutions. This work also demonstrated the potential of the refinement method in bringing up large chunks of missing densities, thus beneficial to structural refinement of many difficult systems...
- Molecular basis of dysfunctional Kv channels in small coronary artery smooth muscle cells of streptozotocin-induced diabetic ratsQiang Chai
Department of Physiology, Shandong Academy of Medical Sciences, Jinan 250062, Shandong, People s Republic of China
Chin J Physiol 50:171-7. 2007....
- Molecular driving forces determining potassium channel slow inactivationJulio F Cordero-Morales
Department of Molecular Physiology and Biological Physics, University of Virginia, 1300 JPA, Charlottesville, Virginia 22908, USA
Nat Struct Mol Biol 14:1062-9. 2007..2 suggests that a similar mechanistic principle applies to other K+ channels. These observations provide a plausible physical framework for understanding C-type inactivation in K+ channels...
- Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brainW Stuhmer
Max Planck Institut fur biophysikalische Chemie, Abteilung Membranbiophysik, Gottingen, FRG
EMBO J 8:3235-44. 1989....
- Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene familyD McKinnon
Department of Pharmacology, Washington University Medical School, St Louis, Missouri 63110
J Biol Chem 264:8230-6. 1989..This new potassium channel is called BK2 to distinguish it from the previously described potassium channel (BK1)...
- Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinasesE Kim
Howard Hughes Medical Institute, Massachusetts General Hospital, Department of Neurobiology, Harvard Medical School, Boston 02114, USA
Nature 378:85-8. 1995..3) and syntrophin), suggest that PDZ-domain-containing polypeptides may be widely involved in the organization of proteins at sites of membrane specialization...
- Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channelsS Poliak
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
Neuron 24:1037-47. 1999..This association involves the C-terminal sequence of Caspr2, which contains a putative PDZ binding site. These results suggest a role for Caspr family members in the local differentiation of the axon into distinct functional subdomains...
- The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channelD L Minor
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco 94143, USA
Cell 102:657-70. 2000..Together, these data suggest that structural changes involving the buried polar T1 surfaces play a key role in the conformational changes leading to channel opening...
- KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expressionY A Kuryshev
The Rammelkamp Center for Education and Research, MetroHealth Campus, Cleveland, Ohio 44109, USA
Am J Physiol Cell Physiol 281:C290-9. 2001..2 may alter both sustained and transient cardiac Kv currents. The interaction of these two different classes of modulatory proteins may constitute a novel mechanism for regulating cardiac K+ currents...
- Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactinDavid Hattan
Department of Pharmacology, University of Vermont College of Medicine, Burlington, Vermont 04505, USA
J Biol Chem 277:38596-606. 2002..These results demonstrate a dynamic, phosphorylation-dependent interaction between Kv1.2 and the actin cytoskeleton-binding protein cortactin and suggest a role for that interaction in the regulation of Kv1.2 ionic current...
- Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasionPaul D Dodson
Department of Cell Physiology and Pharmacology, University of Leicester, PO Box 138, Leicester LE1 9HN, UK
J Physiol 550:27-33. 2003..We conclude that Kv1.2 channels have a general presynaptic function in suppressing terminal hyperexcitability during the depolarising after-potential...
- Developmental regulation and adult maintenance of potassium channel proteins (Kv 1.1 and Kv 1.2) in the cochlear nucleus of the ratElena Caminos
Facultad de Medicina and Centro Regional de Investigaciones Biomédicas CRIB, Universidad de Castilla La Mancha, 02006 Albacete, Spain
Brain Res 1056:118-31. 2005..Thus, normal excitatory synaptic input in adult animals is not a requirement to regulate the expression and cellular and subcellular distribution of these potassium channel proteins...
- Mu opioid receptor activation inhibits GABAergic inputs to basolateral amygdala neurons through Kv1.1/1.2 channelsThomas F Finnegan
Department of Anesthesiology, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey Pennsylvania, USA
J Neurophysiol 95:2032-41. 2006..This study provides new information that activation of presynaptic mu opioid receptors primarily attenuates GABAergic synaptic inputs to CeA-projecting neurons in the BLA through a signaling mechanism involving Kv1.1 and Kv1.2 channels...
- Glycosylation and cell surface expression of Kv1.2 potassium channel are regulated by determinants in the pore regionTetsuhiro Fujita
Department of Pharmacotherapeutics, Showa Pharmaceutical University, Tokyo, Machida, Japan
Neurochem Res 31:589-96. 2006..2 and cells coexpressing beta2and S360A. These results suggest that amino acids in the pore region help regulate ion permeability or cellular trafficking by affecting glycosylation of Kv1.2...
- Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic ratsAaron H Bubolz
Department of Medicine, The Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Am J Physiol Heart Circ Physiol 293:H2231-7. 2007..Eb may be beneficial for the therapeutic treatment of vascular complications in diabetes mellitus...
- Cloning and expression of a rat cardiac delayed rectifier potassium channelM Paulmichl
Department of Pharmacology, Mayo Foundation, Rochester, MN 55905
Proc Natl Acad Sci U S A 88:7892-5. 1991..RAK differs from the cloned rat brain K current, BK2 [McKinnon, D. (1989) J. Biol. Chem. 264, 8230-8236], by one amino acid at residue 411...
- HYPERTENSION: CONTRIBUTION OF ARTERIAL WALL CHANGESRobert Cox; Fiscal Year: 2007..These studies will define a novel therapeutic target for antihypertensive drug development based upon the mechanism(s) of Ca2+-Kv channel modulation. ..