Itga2

Summary

Gene Symbol: Itga2
Description: integrin subunit alpha 2
Alias: CD49B, GPIa, HPA-5, integrin alpha-2, integrin alpha 2, platelet glycoprotein Ia
Species: rat

Top Publications

  1. ncbi Type I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-alpha2beta1 integrin interaction
    M Mizuno
    Department of Biochemistry, School of Dentistry, Hokkaido University, Sapporo, Japan
    J Cell Physiol 184:207-13. 2000
  2. ncbi Decreased expression of alpha2 integrin in fibroblasts isolated from cyclosporin A- induced gingival overgrowth in rats
    Masatoshi Kataoka
    Department of Periodontology and Endodontology, Tokushima University School of Dentistry, Kuramoto, Tokushima, Japan
    J Periodontal Res 38:533-7. 2003
  3. ncbi Integrin alpha2beta1 affects mechano-transduction in slowly and rapidly adapting cutaneous mechanoreceptors in rat hairy skin
    P S Khalsa
    Department of Biomedical Engineering, State University of New York, HSC T18 031, Stony Brook, NY 11794 8181, USA
    Neuroscience 129:447-59. 2004
  4. ncbi The expression of mesenchymal, neural and haematopoietic stem cell markers in adult hepatocytes proliferating in vitro
    Sarah Koenig
    Department of General Surgery, Georg August University Goettingen, Germany
    J Hepatol 44:1115-24. 2006
  5. ncbi Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 47:1959-66. 2006
  6. pmc EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes
    Haitao Li
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong, China
    Mol Vis 14:1698-704. 2008
  7. ncbi Glomerular epithelial and mesangial cells differentially modulate the binding specificities of VLA-1 and VLA-2
    D L Mendrick
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts
    Lab Invest 72:367-75. 1995
  8. pmc Association analysis of genetic variations of eNOS and α2β1 integrin genes with type 2 diabetic retinopathy
    Rania Azmy
    Medical Biochemistry Department, Menoufiya University, Shebin Elkom, Egypt
    Appl Clin Genet 5:55-65. 2012
  9. doi Idiopathic sudden sensorineural hearing loss: classic cardiovascular and new genetic risk factors
    F Ballesteros
    Department of Otorhinolaryngology, Head and Neck Surgery, Hospital Clinic, Barcelona, Spain
    Audiol Neurootol 17:400-8. 2012
  10. pmc Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection
    Outi Laine
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Thromb Res 129:611-5. 2012

Research Grants

  1. MOLECULAR BIOLOGY OF COLLAGEN RECEPTORS
    Thomas Kunicki; Fiscal Year: 2004
  2. Molecular Genetics of Integrin Collagen Receptors
    Thomas Kunicki; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications70

  1. ncbi Type I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-alpha2beta1 integrin interaction
    M Mizuno
    Department of Biochemistry, School of Dentistry, Hokkaido University, Sapporo, Japan
    J Cell Physiol 184:207-13. 2000
    ..These findings imply that collagen-alpha 2 beta 1 integrin interaction is an important signal for the osteoblastic differentiation of bone marrow cells...
  2. ncbi Decreased expression of alpha2 integrin in fibroblasts isolated from cyclosporin A- induced gingival overgrowth in rats
    Masatoshi Kataoka
    Department of Periodontology and Endodontology, Tokushima University School of Dentistry, Kuramoto, Tokushima, Japan
    J Periodontal Res 38:533-7. 2003
    ..To elucidate the role of alpha2beta1 integrin in CsA-induced gingival overgrowth, we investigated collagen phagocytosis and alpha2beta1 integrin expression in rat gingival fibroblasts...
  3. ncbi Integrin alpha2beta1 affects mechano-transduction in slowly and rapidly adapting cutaneous mechanoreceptors in rat hairy skin
    P S Khalsa
    Department of Biomedical Engineering, State University of New York, HSC T18 031, Stony Brook, NY 11794 8181, USA
    Neuroscience 129:447-59. 2004
    ..Taken together, the data from this study support the hypothesis that integrin alpha2beta1 plays a significant role in modulating mechanoreceptive response to compressive indentation...
  4. ncbi The expression of mesenchymal, neural and haematopoietic stem cell markers in adult hepatocytes proliferating in vitro
    Sarah Koenig
    Department of General Surgery, Georg August University Goettingen, Germany
    J Hepatol 44:1115-24. 2006
    ..Cultured adult hepatocytes may be stimulated into clonal expansion. We raise the question whether adult hepatocytes proliferating in vitro recapitulate the early process of hepatic development...
  5. ncbi Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 47:1959-66. 2006
    The aim of this research was to evaluate the effect of genetic polymorphisms C807T and G1648A of platelet glycoprotein Ia (GPIa), on the risk for myocardial infarction (MI) and on the release of soluble CD40 ligand (sCD40L) during the ..
  6. pmc EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes
    Haitao Li
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong, China
    Mol Vis 14:1698-704. 2008
    ..We tested the hypothesis that genetic variants in vasoactive and angiogenic factors regulating the retina vasculature contribute to the development of diabetic retinopathy (DR)...
  7. ncbi Glomerular epithelial and mesangial cells differentially modulate the binding specificities of VLA-1 and VLA-2
    D L Mendrick
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts
    Lab Invest 72:367-75. 1995
    ..Because little is known about the receptors utilized by glomerular cells, we examined the attachment of cultured glomerular cells to extracellular matrix proteins...
  8. pmc Association analysis of genetic variations of eNOS and α2β1 integrin genes with type 2 diabetic retinopathy
    Rania Azmy
    Medical Biochemistry Department, Menoufiya University, Shebin Elkom, Egypt
    Appl Clin Genet 5:55-65. 2012
    ..It has been suggested that nitric oxide (NO) and α2β1 integrin (a platelet receptor for collagen) play an important role in the pathogenesis of microvascular complications in DR...
  9. doi Idiopathic sudden sensorineural hearing loss: classic cardiovascular and new genetic risk factors
    F Ballesteros
    Department of Otorhinolaryngology, Head and Neck Surgery, Hospital Clinic, Barcelona, Spain
    Audiol Neurootol 17:400-8. 2012
    ..The clinical picture supports vascular involvement, but obvious limitations of inner ear study make this difficult to corroborate...
  10. pmc Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection
    Outi Laine
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Thromb Res 129:611-5. 2012
    ..The associations of the rarer alleles with variables reflecting the severity of the disease were analyzed...
  11. doi Placental gene expression in a rat 'model' of placental insufficiency
    R Goyal
    Center for Perinatal Biology, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Placenta 31:568-75. 2010
    ..Recent studies have identified the Brown Norway (BN) rat as a natural 'model' of placental insufficiency associated with decreased trophoblast remodeling of maternal uterine arteries...
  12. pmc Infiltrating cells and IFNgamma production in the injected eye after uniocular anterior chamber inoculation of HSV-1
    Heather M Cathcart
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    Invest Ophthalmol Vis Sci 50:2269-75. 2009
    ..The purpose of this study was to identify early infiltrating cells and to determine whether infiltrating cells produce interferon (IFN)gamma...
  13. ncbi Integrin alpha2beta1 regulates neutrophil recruitment and inflammatory activity in experimental colitis in mice
    Sofie Lundberg
    Department of Medicine, Unit of Gastroenterology and Hepatology, Karolinska Institutet, Karolinska University Hospital, Stockholm
    Inflamm Bowel Dis 12:172-7. 2006
    ..The aim of this study was to investigate the role of the collagen-binding alpha2beta1 integrin (CD49b/CD29) in dextran sodium sulfate-induced colitis in mice.
  14. ncbi Smooth muscle actin determines mechanical force-induced p38 activation
    Jiaxu Wang
    Canadian Institutes of Health, Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Ontario, Canada
    J Biol Chem 280:7273-84. 2005
    ..We conclude that force-induced p38 phosphorylation is dependent on an SMA filament-dependent pathway that uses a feed-forward amplification loop to synergize force-induced SMA expression with p38 activation...
  15. ncbi Platelet membrane glycoprotein polymorphisms do not influence the clinical expressivity of von Willebrand disease type 1
    Jaime Pereira
    Department of Haematology Oncology, School of Medicine, Catholic University of Chile, P O Box 114 D, Santiago Chile
    Thromb Haemost 90:1135-40. 2003
    ..PltGPs, HPA-1, 2 and 5 and C807T of GPIa were determined by fluorophore-labelled hybridization probes on a LightCycler...
  16. ncbi Differential effects of CD18, CD29, and CD49 integrin subunit inhibition on neutrophil migration in pulmonary inflammation
    V C Ridger
    Cardiovascular Research Group, Division of Clinical Sciences, Northern General Hospital, University of Sheffield, Sheffield, United Kingdom
    J Immunol 166:3484-90. 2001
    ..mAbs to CD49e and CD49f inhibited both responses, while anti-CD49b and CD49d significantly inhibited responses to KC only...
  17. ncbi The platelet glycoprotein Ia/IIa gene polymorphism C807T/G873A: a novel risk factor for retinal vein occlusion
    P M Dodson
    Department of Medical Ophthalmology Heartlands Hospital Bordesley Green East Birmingham B9 5SS, UK
    Eye (Lond) 17:772-7. 2003
    ..b>Platelet glycoprotein Ia/IIa (GpIa/IIa) is an adhesion molecule mediating platelet-collagen interactions and is key to the ..
  18. ncbi An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees
    T J Kunicki
    Department of Molecular and Experimental Medicine, The Division of Experimental Hemostasis and Thrombosis, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Thromb Haemost 4:137-47. 2006
    ..After Bonferroni correction for multiple testing, only ITGA2 promoter haplotype -52T was associated with an increased bleeding severity score (P < 0.01)...
  19. ncbi Iron deficiency anaemia in young women
    Lena E Carlsson
    Department of Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Eur J Haematol 68:341-4. 2002
    ..density of GPIaIIa, the primary platelet collagen receptor (integrin alpha2beta1), is linked to two polymorphisms (GPIa-807C/T and HPA-5a/b)...
  20. ncbi Predominance of NK1.1+TCR alpha beta+ or DX5+TCR alpha beta+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: "natural suppressor" cells
    F Lan
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 167:2087-96. 2001
    ..1+ and DX5+asialo-GM1+ T cells derived from either donors or hosts conditioned with lymphoid irradiation is dependent on their secretion of high levels of IL-4...
  21. doi Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia
    Nicole Alessandri-Haber
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, San Francisco, California 94143 0440, USA
    J Neurosci 28:1046-57. 2008
    ..We suggest that TRPV4 plays a role in mechanotransduction, as a component of a molecular complex that functions only in the setting of inflammation or nerve injury...
  22. ncbi The role of alpha1beta1 integrin in wound contraction. A quantitative analysis of liver myofibroblasts in vivo and in primary culture
    L Racine-Samson
    Liver Center Laboratory, San Francisco General Hospital, and the Department of Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 272:30911-7. 1997
    ..Although alpha2beta1 is capable of mediating contraction, its expression by myofibroblasts occurs largely, if not exclusively, in response to culture...
  23. ncbi Blocking alpha2 integrins on rat CC531s colon carcinoma cells prevents operation-induced augmentation of liver metastases outgrowth
    Gerben J van der Bij
    Department of Surgical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Hepatology 47:532-43. 2008
    ..As such, we postulate that blood vessel integrity in the liver is compromised after abdominal trauma, resulting in enhanced ECM exposure, which enables tumor cell adhesion and metastases outgrowth...
  24. ncbi Enhanced laminin carbonylation by monocytes in diabetes mellitus
    Elena Kostidou
    Laboratory of Animal Physiology, School of Biology, Aristotle University, Thessaloniki 54124, Greece
    Clin Biochem 40:671-9. 2007
    ..Moreover, reactive oxygen species production was measured. Monocyte attachment and migration through oxidized and non-oxidized laminin were also studied...
  25. ncbi Crucial role of fibroblast integrins alpha2 and beta1 in maintaining the structural and mechanical properties of the skin
    Tsutomu Fujimura
    Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi 321 3497, Japan
    J Dermatol Sci 45:45-53. 2007
    ..However, there are few studies to clarify actual in vivo functions of integrins in the dermis using normal type animals...
  26. ncbi A mandibular propulsive appliance modulates collagen-binding integrins distribution in the young rat condylar cartilage
    Mara Rúbia Marques
    Cell and Developmental Biology Department, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil
    Biorheology 43:293-302. 2006
    ..These results suggest that integrins containing the alpha1 and alpha2 subunits are modulated by forces promoted by the MPA, participating of the biological response to this therapy...
  27. pmc The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells
    X Q Wang
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Biol Cell 9:865-74. 1998
    ..Complex formation between alpha2 beta1 and IAP was detected by the coimmunoprecipitation of both alpha2 and beta1 integrin subunits with IAP. These data suggest that IAP can associate with alpha2 beta1 integrin and modulate its function...
  28. ncbi Vascular risk factors in sudden hearing loss
    Claudia Rudack
    Department of Otorhinolaryngology, Head and Neck Surgery, Munster, Germany
    Thromb Haemost 95:454-61. 2006
    ..In addition, we determined the platelet glycoprotein Ia (GPIa) C807T polymorphism, which was recently proposed to be a genetic risk factor for SHL, and we ..
  29. ncbi Polymorphism of the glycoprotein Ia and IIIa in the group of women in childbirth does not correlate with an increased risk of developing thrombosis
    Lech Podciechowski
    Department of Fetal Maternal Medicine and Gynecology, Polish Mother s Health Research Insitute, Lodz, Poland
    Neuro Endocrinol Lett 26:789-94. 2005
    ..The aim of the study was to evaluate the prevalence of the GP Ia and GP IIIa polymorphisms in the group of women in labor, and to assess the risk of thrombosis associated with their occurrence...
  30. ncbi Hypoxia activates MAPK activity in rat nucleus pulposus cells: regulation of integrin expression and cell survival
    Makarand V Risbud
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Spine (Phila Pa 1976) 30:2503-9. 2005
    ..The aim of the present study was to investigate whether activation of MAPK subtypes ERK and p38 influences integrin expression and promotes nucleus pulposus cell survival in hypoxia...
  31. ncbi Phenotypic heterogeneity influences the behavior of rat aortic smooth muscle cells in collagen lattice
    Augusto Orlandi
    Anatomic Pathology, Dept of Biopathology and Image Diagnostics, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy
    Exp Cell Res 311:317-27. 2005
    ..Heterogeneity in proliferation and cytoskeleton as well the capacity to remodel the extracellular matrix are maintained, when SMCs are suspended in PCLs...
  32. pmc Plasmacytoid precursor dendritic cells from NOD mice exhibit impaired function: are they a component of diabetes pathogenesis?
    Yiming Huang
    Institute for Cellular Therapeutics, University of Louisville, Louisville, Kentucky, USA
    Diabetes 57:2360-70. 2008
    ..Here, we evaluated the phenotype and function of CD8(+)/TCR(-) FCs from NOD mice...
  33. ncbi Collagen phagocytosis by fibroblasts is regulated by decorin
    Vinay M Bhide
    Canadian Institutes of Health Research Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Ontario
    J Biol Chem 280:23103-13. 2005
    ..Thus a novel collagen binding domain in decorin acts cooperatively with leucine-rich repeat 4 to mask the alpha2beta1 integrin-binding site on collagen, an important sequence for the phagocytosis of collagen fibrils...
  34. doi Role of MT1-MMP in the osteogenic differentiation
    Paola Manduca
    Genetics, DIBIO, University of Genoa, 26, C Europa, Genoa 16132, Italy
    Bone 44:251-65. 2009
    ..MT1-MMP has multiple functions and is implicated in multiple steps of the differentiation process, acting to regulate homeostasis of the osteogenic differentiation...
  35. ncbi Improvement of fertility with adoptive CD25+ natural killer cell transfer in subfertile non-obese diabetic mice
    Wenjing Wang
    Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou, China
    Reprod Biomed Online 18:95-103. 2009
    ..0%; P < 0.01). Improved fertility was concomitant with an increase in placental CD49b(+) NK cells expressing Foxp3. Foxp3 expression was confirmed in the CD25(+) NK cells before the transfer...
  36. pmc The integrin alpha2beta1 agonist, aggretin, promotes proliferation and migration of VSMC through NF-kB translocation and PDGF production
    Ching Hu Chung
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Br J Pharmacol 156:846-56. 2009
    ..Here, we investigate the mechanism of VSMC migration and proliferation caused by aggretin, a snake venom integrin alpha2beta1 agonist...
  37. doi Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2(+)ISG20(+) natural killer-cell transfer
    Yi Lin
    Department of Obstetrics and Gynecology, School of Medicine, Institute of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiaotong University, Shanghai, People s Republic of China
    Reproduction 137:943-55. 2009
    ..ganglio-N-tetraosylceramide to deplete NK cells, but was decreased by the adoptive transfer of ITGA2(+)ISG20(+) (CD49b(+) CD25(+)) NK cells from normal mice. No such trend was observed in syngeneic pregnant NOD mice...
  38. ncbi Collagen phagocytosis and apoptosis are induced by high level alkaline phosphatase expression in rat fibroblasts
    M Z Hui
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Cell Physiol 172:323-33. 1997
    ..High-level AP expression promotes cell deletion by apoptosis. We suggest that the expression of AP by fibroblasts indicates a novel role for this enzyme in collagen degradation by phagocytosis...
  39. doi Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin alpha2
    Sojoong Choi
    Department of Life Sciences, Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul 120 750, Republic of Korea
    Biochem Biophys Res Commun 384:231-5. 2009
    ..This interactive dynamic might be a possible mechanism underlying the tumorigenic activities of colon cancer cells...
  40. ncbi Ascorbic acid alters collagen integrins in bone culture
    D R Ganta
    Department of Orthopaedics, University of Connecticut Health Center, Farmington 06032, USA
    Endocrinology 138:3606-12. 1997
    ..Integrin assays for specific extracellular proteins may be useful tools in detecting matrix defects in various metabolic bone diseases...
  41. doi Progesterone modulates integrin {alpha}2 (ITGA2) and {alpha}11 (ITGA11) in the pregnant cervix
    Huiling Ji
    Department of Obstetrics and Gynecology, Section of Maternal Fetal Medicine, The Warren Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, RI 02905, USA
    Reprod Sci 18:156-63. 2011
    ..We investigated the expression of collagen-binding integrins in the normal rat gestation and after treatment with mifepristone to determine whether integrin modulation is involved in changes in tissue resistance...
  42. ncbi Polyamines are important for attachment of IEC-6 cells to extracellular matrix
    M F Santos
    Department of Physiology and Biophysics, College of Medicine, University of Tennessee, Memphis 38163, USA
    Am J Physiol 273:G175-83. 1997
    ..This study demonstrates that polyamines are important for cell attachment and expression of the integrin alpha 2 beta 1, a putative receptor for collagen and laminin...
  43. ncbi Distribution of integrin subunits in human diabetic kidneys
    D K Jin
    Department of Pediatrics, Samsung Medical Center, Seoul, Korea
    J Am Soc Nephrol 7:2636-45. 1996
    ..Given the role of integrins in cell-surface interactions with extracellular matrix components, abnormalities in the expression of these molecules may be important in the pathogenesis of diabetic nephropathy...
  44. ncbi Alpha 2 beta 1 integrin is required for the collagen and FGF-1 induced cell dispersion in a rat bladder carcinoma cell line
    A M Valles
    UMR 144, CNRS, Subcellular Structure and Cellular Dynamics, Institute Curie Research Division, Paris, France
    Cell Adhes Commun 4:187-99. 1996
    ..They also indicate that a functional alpha 2 integrin is essential for the motile behavior of NBT-II cells during the FGF-1 induced EMT...
  45. ncbi Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development
    J E Wu
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110
    Dev Dyn 199:292-314. 1994
    ..The developmental expression pattern of the alpha 2 beta 1 integrin suggests roles for the integrin in placental development and matrix assembly and remodeling...
  46. ncbi [The effect of mechanical stimulation on the expression of alpha 2, beta 1, beta 3 integrins and the proliferation, synthetic function in rat osteoblasts]
    Liang Li
    Institute of Biomedical Engineering, Basic Medicine and Forensic Medicine College, Sichuan University, Chengdu 610041
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 20:187-92. 2003
    ..Accordingly it indicates that integrins have a important role in regulation of signal transduction pathway in osteoblasts as a result of mechanical strain...
  47. ncbi Time course of changes in serum glucose, insulin, lipids and tissue lipase activities in macrosomic offspring of rats with streptozotocin-induced diabetes
    H Merzouk
    Laboratoire de Physiologie Animale, université de Tlemcen, Algerie
    Clin Sci (Lond) 98:21-30. 2000
    ..In conclusion, macrosomia was associated with alterations in glucose and lipid metabolism through to adulthood. It should be considered as an important potential risk factor for obesity and its metabolic complications...
  48. ncbi Integrin alpha(2)beta(1) (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue
    J Werr
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Blood 95:1804-9. 2000
    ..Blood. 2000;95:1804-1809)..
  49. ncbi Platelet glycoprotein Ia gene dimorphism alpha2-807 in malignant arrhythmia in coronary artery disease
    A Anvari
    Clinic of Internal Medicine II, Department of Cardiology, Vienna, Austria
    Thromb Res 98:281-6. 2000
    ..There was no overrepresentation of an allele in any group. The inherited dimorphism that is associated with the levels of platelet integrin alpha2beta1 is not associated with malignant arrhythmia in coronary artery disease patients...
  50. ncbi Distinct structural forms of type I collagen modulate cell cycle regulatory proteins in mesangial cells
    H O Schöcklmann
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Erlangen, Germany
    Kidney Int 58:1108-20. 2000
    ..In glomerulonephritis, type I collagen accumulates in the mesangium and is constantly structurally modified and degraded during the course of the disease...
  51. ncbi Identification of a heparin binding site and the biological activities of the laminin alpha1 chain carboxy-terminal globular domain
    I Yoshida
    Department of Neuro Psychiatry, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Cell Physiol 179:18-28. 1999
    ....
  52. ncbi Modulation of alpha2beta1 integrin changes during mammary gland development by beta-oestradiol
    T Iype
    Department of Biochemistry, University of Kerala, India
    Biochim Biophys Acta 1499:232-41. 2001
    ..These results indicate that oestrogen, apart from directly affecting the cellular activity, can influence mammary tissue function by affecting cell-ECM interactions through the modulation of integrin receptors for matrix proteins...
  53. ncbi Parathyroid hormone (1-34) regulates integrin expression in vivo in rat osteoblasts
    E Kaiser
    Gene Regulation, Bone, and Inflammation Research, DC0403, Lilly Research Laboratories, Eli Lilly and Company, Corporate Center, Indianapolis, IN 46285, USA
    J Cell Biochem 83:617-30. 2001
    ....
  54. ncbi Differential integrin expression by cardiac fibroblasts from hypertensive and exercise-trained rat hearts
    Maria Lonnett Burgess
    Laboratory of Cardiovascular Biology, Department of Health Sciences, Boston University, 675 Commonwealth Ave, Boston, MA 02215, USA
    Cardiovasc Pathol 11:78-87. 2002
    ..They also suggest a pragmatic use for primary cardiac fibroblasts as a model to study the cardiac matrix remodeled by physiological (exercise) and pathological (hypertension) stressors...
  55. ncbi The 807T allele in alpha2 integrin is protective against atherosclerotic arterial wall thickening and the occurrence of plaque in patients with type 2 diabetes
    Takaaki Maeno
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Diabetes 51:1523-8. 2002
    ..These results suggest that the number of 807T alleles in alpha2 integrin is protective against atherosclerotic arterial wall thickening and the occurrence of plaque in patients with type 2 diabetes...
  56. ncbi Association of the platelet glycoprotein Ia C807T/G873A gene polymorphism and thrombosis in Behçet patients
    Gurbuz Polat
    Mersin University, Medical Faculty, Department of Biochemistry, Turkey
    Haematologia (Budap) 32:121-8. 2002
    ..We determined the prevalence of platelet glycoprotein Ia C807T/G873A gene polymorphism in Behçet patients...
  57. ncbi Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Thromb Haemost 89:142-8. 2003
    ..019). These results suggest the hypothesis that genetic variation of platelet glycoprotein Ia may play a particularly important role during the advanced stages of diabetic retinopathy.
  58. ncbi Distribution of alpha and beta integrin subunits in the adult rat hippocampus after pilocarpine-induced neuronal cell loss, axonal reorganization and reactive astrogliosis
    K Fasen
    Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Str 25, 53127 Bonn, Germany
    Acta Neuropathol 106:319-22. 2003
    ....
  59. ncbi Role of thrombophilic gene polymorphisms in branch retinal vein occlusion
    Martin Weger
    Department of Ophthalmology, Medical University Graz, Graz, Austria
    Ophthalmology 112:1910-5. 2005
    ..The present study was therefore done to determine the prevalence of genetic polymorphisms in factors implicated in hypercoagulability among patients with BRVO...
  60. ncbi Collagen platelet receptor polymorphisms integrin alpha2beta1 C807T and GPVI Q317L and risk of ischemic stroke
    V J Cole
    Thrombosis and Haemophilia Unit, Royal Perth Hospital, Perth, Australia
    J Thromb Haemost 1:963-70. 2003
    ..Our results do not support a role for the integrin alpha2 C807T and GPVI Q317L polymorphisms in the development of first-ever ischemic stroke. However, larger studies are required to confirm this...
  61. ncbi Induction of cellular processes containing collagenase and retinoid by integrin-binding to interstitial collagen in hepatic stellate cell culture
    M Sato
    Department of Anatomy, Akita University School of Medicine, Akita, 010 8543, Japan
    Cell Biol Int 22:115-25. 1998
    ..The lipid droplets and vitamin A-autofluorescence were increased by retinyl acetate addition to the culture medium, suggesting an important role of processes in hepatic stellate cell function...
  62. ncbi Glanzmann's thrombasthenia: modulation of clinical phenotype by alpha2C807T gene polymorphism
    Giovanna D'Andrea
    Unità di Aterosclerosi e Trombosi IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, San Giovanni Rotondo, Foggia
    Haematologica 88:1378-82. 2003
    ..The expression of Glanzmann's thromboasthenia (GT) varies, even among patients carrying the same mutation. It is conceivable that other gene loci may influence the clinical expression of GT and lead to specific phenotypes...
  63. ncbi Improved metabolic control decreases platelet activation markers in patients with type-2 diabetes
    N Eibl
    Rudolfstiftung Hospital, Vienna, Austria
    Eur J Clin Invest 34:205-9. 2004
    ..Our study attempts to clarify the effect of improved metabolic control on platelet activation markers in patients with type-2 diabetes...
  64. ncbi Differential susceptibility of osteosarcoma cells and primary osteoblasts to cell detachment caused by snake venom metalloproteinase protein
    Chih Hsin Tang
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Sec 1 Jen Ai Road, Taipei 100, Taiwan
    Toxicon 43:11-20. 2004
    ..8 is much more susceptible to be detached by crovidisin. The matrix degradation by crovidisin may be responsible for the preferential detachment of ROS 17/2.8 osteosarcoma cells...
  65. ncbi Correlation between the polymorphism of glycoprotein Ia gene and acute coronary syndrome
    Yonghui Zhao
    Department of Cardiology, First Hospital, Xi an Jiaotong University, Xi an 710061
    Chin Med Sci J 19:13-8. 2004
    ..Previous studies indicated that variations of GPIa/IIa density and function are associated with the 807 C/T polymorphism of GPIa gene in American and Spanish ..
  66. ncbi Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population
    Sungha Park
    Division of Cardiology, Yonsei University College of Medicine, Seoul 120 752, South Korea
    Yonsei Med J 45:428-34. 2004
    ..In this study, we investigated the role of GPIa, HPA-1 and HPA-3 polymorphisms as putative risk factors for myocardial infarction (MI) and the extent of coronary ..
  67. ncbi Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy
    Makarand V Risbud
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Spine (Phila Pa 1976) 29:2627-32. 2004
    ..Because mesenchymal stem cells can differentiate into chondrocyte-like cells, we ask the question, can mesenchymal stem cells commit to the nucleus pulposus phenotype?..
  68. ncbi Inherited platelet glycoprotein polymorphisms and a risk for coronary heart disease in young central Europeans
    W R Sperr
    Department of Cardiology, University of Vienna, Austria
    Thromb Res 90:117-23. 1998
    Among central Europeans polymorphisms of GPIIIa, GPIb, GPIIb, and GPIa named human platelet antigen-1 (HPA-1), -2, -3, and -5 are the clinically most relevant systems in which alloimmunization occurs...
  69. ncbi Association of the platelet glycoprotein Ia C807T gene polymorphism with nonfatal myocardial infarction in younger patients
    S Santoso
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University Giessen, Giessen, Germany
    Blood 93:2449-53. 1999
    ..two alleles of the glycoprotein (GP) Ia gene, designated C807 and T807, are associated with low or high platelet GPIa-IIa density and consequently with slower or faster rate of platelet adhesion to type I collagen, respectively...

Research Grants2

  1. MOLECULAR BIOLOGY OF COLLAGEN RECEPTORS
    Thomas Kunicki; Fiscal Year: 2004
    DESCRIPTION: (Investigator's abstract) Platelet GPVI and integrin alpha 2/beta 1 cooperate closely to mediate effective platelet adhesion to collagens and subsequent platelet procoagulant activity...
  2. Molecular Genetics of Integrin Collagen Receptors
    Thomas Kunicki; Fiscal Year: 2007
    The integrin alpha-1 gene (ITGA1) and alpha-2 gene (ITGA2) each encode a subunit that directs specificity for collagens...