Irf4

Summary

Gene Symbol: Irf4
Description: interferon regulatory factor 4
Alias: interferon regulatory factor 4
Species: rat

Top Publications

  1. ncbi Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
    S Iida
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nat Genet 17:226-30. 1997
  2. ncbi MUM1/IRF4 expression is an unfavorable prognostic factor in B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
    Masato Ito
    Second Department of Internal Medicine, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601
    Jpn J Cancer Res 93:685-94. 2002
  3. ncbi Expression of MUM1/IRF4 correlates with clinical outcome in patients with B-cell chronic lymphocytic leukemia
    Chung Che Chang
    Department of Pathology, Division of Hematology Oncology, and Division of Biostatistics, Medical College of Wisconsin, Milwaukee 53226, USA
    Blood 100:4671-5. 2002
  4. doi An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males
    Thuy N Do
    Genomic Immunoepidemiology Laboratory, HUMIGEN LLC, The Institute for Genetic Immunology, 2439 Kuser Road, Hamilton, NJ 08690 3303, USA
    Biochim Biophys Acta 1802:292-300. 2010
  5. pmc Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis
    Seung Hee Jo
    Rosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, MA, USA
    Blood 116:2759-67. 2010
  6. ncbi Detection of MUM1/IRF4-IgH fusion in multiple myeloma
    S Yoshida
    Second Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan
    Leukemia 13:1812-6. 1999
  7. doi Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke
    Yinyao Lin
    Department of Neurology, The Third Affiliated Hospital of Sun Yat Sen University, NO 600 TianHe Road, Guangzhou, Guangdong, China
    Neurol Sci 36:913-20. 2015
  8. pmc Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias
    Alex Yick Lun So
    Department of Biology, California Institute of Technology, Pasadena, CA
    Blood 124:1502-12. 2014
  9. doi A key role for interferon regulatory factors in mediating early-life metabolic defects in male offspring of maternal protein restricted rats
    M F P Silvestre
    Centre for Diabetes, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Horm Metab Res 46:252-8. 2014
  10. pmc Implication of IRF4 aberrant gene expression in the acute leukemias of childhood
    Maria Adamaki
    Pediatric Hematology Oncology Unit, First Department of Pediatrics, University of Athens, Aghia Sofia Children s Hospital, Athens, Greece
    PLoS ONE 8:e72326. 2013

Scientific Experts

  • Uma N Sundram
  • Qing Lan
  • Antonia Lopez-Girona
  • Maria Adamaki
  • Chung Che Chang
  • A L Feldman
  • Shibin Ma
  • Vipul Shukla
  • Runqing Lu
  • Shantaram S Joshi
  • Yinyao Lin
  • Alex Yick Lun So
  • M F P Silvestre
  • Mark J Roberts
  • Ding Sheng Jiang
  • Violaine Havelange
  • Simanta Pathak
  • Thuy N Do
  • Seung Hee Jo
  • Dalemari Crowther-Swanepoel
  • D Heintel
  • Kikkeri N Naresh
  • Yanqiang Wang
  • Suqin Chen
  • Haiyan Li
  • Lei Zhang
  • Yongqiang Dai
  • Bingjun Zhang
  • Zhengqi Lu
  • P W Caton
  • Reeshelle Sookram
  • Ee Lyn Lim
  • Shuai Jiang
  • M J Holness
  • David Baltimore
  • Masato Ito
  • Christopher Keown
  • Parameswaran Ramakrishnan
  • Jocelyn Tammy Kim
  • M C Sugden
  • Aarathi Minisandram
  • Yvette Garcia Flores
  • Aadel A Chaudhuri
  • David Cheng
  • J Kieswich
  • M M Yaqoob
  • Catherine Xie
  • Qinglin Yang
  • Rui Zhang
  • Shu Min Zhang
  • Richard R Hardy
  • Shuo Ma
  • Yan Zhang
  • Yi Liu
  • Zhou Yan Bian
  • Leilei Fang
  • Amy Chadburn
  • S Iida
  • LoAnn C Peterson
  • Yingjie Chen
  • Hongliang Li
  • Elizabeth Hyjek
  • Xiao Dong Zhang
  • Guo Chang Fan
  • Karen A Gould
  • Carlo M Croce
  • Hansjuerg Alder
  • Tatsuya Nakamura
  • Long Trinh
  • Yuri Pekarsky
  • James Eudy
  • Laura Rassenti
  • Thomas Kipps
  • Alexey Palamarchuk
  • Kay Uwe Wagner
  • Mobshra Qureshi
  • Harinder Singh
  • Ruibao Ren
  • Yussanne Ma
  • Charronne F Davis
  • Jayaram Vijayakrishnan
  • Jonathan H Schatz
  • Peter Broderick
  • Brittany A Morrison
  • Estella Matutes
  • Daniel Catovsky
  • Lindsay Robertson
  • Claire Dearden
  • Richard S Houlston
  • Jaime Acquaviva

Detail Information

Publications24

  1. ncbi Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
    S Iida
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nat Genet 17:226-30. 1997
    ..The translocation juxtaposes the immunoglobulin heavy-chain (IgH) locus to MUM1 (multiple myeloma oncogene 1)/IRF4 gene, a member of the interferon regulatory factor (IRF) family known to be active in the control of B-cell ..
  2. ncbi MUM1/IRF4 expression is an unfavorable prognostic factor in B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
    Masato Ito
    Second Department of Internal Medicine, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601
    Jpn J Cancer Res 93:685-94. 2002
    ..The biological role and mechanism of action of MUM1 in B-CLL / SLL need to be clarified for the development of therapies for patients with the poor prognostic subtype...
  3. ncbi Expression of MUM1/IRF4 correlates with clinical outcome in patients with B-cell chronic lymphocytic leukemia
    Chung Che Chang
    Department of Pathology, Division of Hematology Oncology, and Division of Biostatistics, Medical College of Wisconsin, Milwaukee 53226, USA
    Blood 100:4671-5. 2002
    In this study, we evaluated the prognostic significance of multiple myeloma-1/interferon regulatory factor-4 (MUM1/IRF4) expression in B-cell chronic lymphocytic leukemia (B-CLL)...
  4. doi An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males
    Thuy N Do
    Genomic Immunoepidemiology Laboratory, HUMIGEN LLC, The Institute for Genetic Immunology, 2439 Kuser Road, Hamilton, NJ 08690 3303, USA
    Biochim Biophys Acta 1802:292-300. 2010
    ..b>IRF4 is involved in the differentiation of B and T cells and is overexpressed in B-cell malignancies as a result of c-..
  5. pmc Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis
    Seung Hee Jo
    Rosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, MA, USA
    Blood 116:2759-67. 2010
    b>Interferon regulatory factor 4 (IRF-4) plays important functions in B- and T-cell development and immune response regulation and was originally identified as the product of a proto-oncogene involved in chromosomal translocations in ..
  6. ncbi Detection of MUM1/IRF4-IgH fusion in multiple myeloma
    S Yoshida
    Second Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan
    Leukemia 13:1812-6. 1999
    MUM1 (multiple myeloma oncogene 1)/IRF4 (interferon regulatory factor 4) gene has been identified as an oncogene transcriptionally activated by t(6;14)(p25;q32) chromosomal translocation in multiple myeloma (MM)...
  7. doi Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke
    Yinyao Lin
    Department of Neurology, The Third Affiliated Hospital of Sun Yat Sen University, NO 600 TianHe Road, Guangzhou, Guangdong, China
    Neurol Sci 36:913-20. 2015
    ..Comparing with sham-operated group, the levels of IL-4, TGF-β, PU.1, IRF4, OX40, NIK, RelB-p52 and IL-9 in experimental groups were significantly higher after middle cerebral artery ..
  8. pmc Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias
    Alex Yick Lun So
    Department of Biology, California Institute of Technology, Pasadena, CA
    Blood 124:1502-12. 2014
    ..and genetic analyses, we demonstrated that miR-125b induces myeloid and B-cell leukemia by inhibiting interferon regulatory factor 4 (IRF4) but through distinct mechanisms; it induces myeloid leukemia through repressing IRF4 at the ..
  9. doi A key role for interferon regulatory factors in mediating early-life metabolic defects in male offspring of maternal protein restricted rats
    M F P Silvestre
    Centre for Diabetes, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Horm Metab Res 46:252-8. 2014
    ..Recent studies have demonstrated that interferon regulatory factors 3 (IRF3) and 4 (IRF4) function to repress adipogenesis...
  10. pmc Implication of IRF4 aberrant gene expression in the acute leukemias of childhood
    Maria Adamaki
    Pediatric Hematology Oncology Unit, First Department of Pediatrics, University of Athens, Aghia Sofia Children s Hospital, Athens, Greece
    PLoS ONE 8:e72326. 2013
    ..The Interferon Regulatory Factor 4 (IRF4) gene encodes a transcription factor important for key developmental stages of hematopoiesis, ..
  11. pmc A role for IRF4 in the development of CLL
    Vipul Shukla
    Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, NE and
    Blood 122:2848-55. 2013
    b>Interferon regulatory factor 4 (IRF4) is a critical transcriptional regulator of B-cell development and function...
  12. pmc Accelerated development of chronic lymphocytic leukemia in New Zealand Black mice expressing a low level of interferon regulatory factor 4
    Shibin Ma
    From the Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198
    J Biol Chem 288:26430-40. 2013
    A recent genome-wide SNP association study identified IRF4 as a major susceptibility gene for chronic lymphocytic leukemia (CLL). Moreover, the SNPs located in the 3' UTR of the IRF4 gene have been linked to a down-regulation of IRF4...
  13. doi Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia
    Mark J Roberts
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Clin Pathol 139:210-9. 2013
    ..In this study, the expression patterns of PAX5/BSAP, MUM1/IRF4, and PRDM1/BLIMP1 were analyzed in plasma cells and lymphocytes in 29 cases of newly diagnosed LPL/WM by double ..
  14. pmc IRF4 is a suppressor of c-Myc induced B cell leukemia
    Simanta Pathak
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e22628. 2011
    b>Interferon regulatory factor 4 (IRF4) is a critical transcriptional regulator in B cell development and function...
  15. pmc IRF4 mutations in chronic lymphocytic leukemia
    Violaine Havelange
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Blood 118:2827-9. 2011
    b>Interferon regulatory factor 4 (IRF4) is a member of the interferon regulatory factor family of transcription factors and has been shown to have critical functions at several stages of B-cell development...
  16. doi Fine-scale mapping of the 6p25.3 chronic lymphocytic leukaemia susceptibility locus
    Dalemari Crowther-Swanepoel
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Hum Mol Genet 19:1840-5. 2010
    ..the association signal to a 18 kb DNA segment within the 3'-untranslated region (UTR) of the IRF4 (interferon regulatory factor 4) gene...
  17. pmc Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas
    A L Feldman
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 23:574-80. 2009
    ..we identified recurrent translocations involving the multiple myeloma oncogene-1/interferon regulatory factor-4 (IRF4) locus in PTCLs...
  18. ncbi Expression of MUM1/IRF4 mRNA as a prognostic marker in patients with multiple myeloma
    D Heintel
    Leukemia 22:441-5. 2008
  19. ncbi MUM1 expression dichotomises follicular lymphoma into predominantly, MUM1-negative low-grade and MUM1-positive high-grade subtypes
    Kikkeri N Naresh
    Haematologica 92:267-8. 2007
    We investigated the expression of MUM1 (multiple myeloma oncogene 1)/IRF4 (interferon regulatory factor 4) in 46 cases of follicular lymphoma (FL) and correlated this with grade and expression of CD10, Bcl-6 and Ki-67...
  20. doi Lenalidomide downregulates the cell survival factor, interferon regulatory factor-4, providing a potential mechanistic link for predicting response
    Antonia Lopez-Girona
    Translational Development Department, Celgene, San Diego, CA 92122, USA
    Br J Haematol 154:325-36. 2011
    Overexpression of the transcription factor interferon regulatory factor-4 (IRF4), which is common in multiple myeloma (MM), is associated with poor prognosis...
  21. pmc Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Eur J Haematol 85:492-5. 2010
    ..The rs872071 variant (Odds Ratio (95% Confidence Interval) = 1.78 (1.25-2.53), P = 0.0013) in the IRF4 gene region showed the strongest association, similar to that reported in the UK study...
  22. pmc Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy
    Ding Sheng Jiang
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0575, USA
    Hypertension 61:1193-202. 2013
    b>IRF4, a member of the interferon regulatory factor (IRF) family, was previously shown to be restricted in the immune system and involved in the differentiation of immune cells...
  23. ncbi Expression of the bcl-6 and MUM1/IRF4 proteins correlate with overall and disease-specific survival in patients with primary cutaneous large B-cell lymphoma: a tissue microarray study
    Uma Sundram
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    J Cutan Pathol 32:227-34. 2005
    ..Initial microarray studies of these lymphomas have implicated several genes as important predictors of outcome. In this study, we used a tissue microarray (TMA) to characterize primary cutaneous large B-cell lymphomas (PCLBCL)...