interleukin 4 receptor

Summary

Gene Symbol: interleukin 4 receptor
Description: interleukin 4 receptor
Alias: Il4ra, interleukin-4 receptor subunit alpha, IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, interleukin 4 receptor, alpha, interleukin-4 receptor alpha chain
Species: rat

Top Publications

  1. doi IL-4 is proangiogenic in the lung under hypoxic conditions
    Kazuyo Yamaji-Kegan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    J Immunol 182:5469-76. 2009
  2. pmc Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma
    Raffi Tachdjian
    Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Exp Med 206:2191-204. 2009
  3. doi Interleukin-4 receptor polymorphisms in asthma and allergy: relation to different disease phenotypes
    B Hesselmar
    Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden
    Acta Paediatr 99:399-403. 2010
  4. pmc Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 70:230-6. 2002
  5. ncbi Haplotypes of the interleukin-4 receptor alpha chain gene associate with susceptibility to and severity of atopic asthma
    A M Hytönen
    Department of Clinical Immunology, Sahlgrenska University Hospital, University of Goteborg, Goteborg, Sweden
    Clin Exp Allergy 34:1570-5. 2004
  6. ncbi Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms
    Barbara Hoebee
    Laboratory for Health Effects Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 187:2-11. 2003
  7. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
  8. ncbi Association of IL4R gene polymorphisms with asthma in Chinese populations
    Haibing Zhang
    Institute of Health Science, Shanghai Institutes for Biological Sciences of CAS and Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China
    Hum Mutat 28:1046. 2007
  9. ncbi V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function
    Kimberly A Risma
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 169:1604-10. 2002
  10. ncbi The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor
    G K Hershey
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 337:1720-5. 1997

Scientific Experts

  • Tian pen Cui
  • Ahmad A Al Robaee
  • Elizabeth E Brown
  • Hoke W Pollock
  • Louis N Irwin
  • Sally Wenzel
  • Kathleen M Eyster
  • Ann Marie Bergin
  • B Hesselmar
  • Carolyn Hoppe
  • Barbara Hoebee
  • D B Mirel
  • M Arvidsson
  • M J Loza
  • T Silvestri
  • Yuji Nakamaru
  • Raj K Puri
  • Teresa García-Berrocoso
  • Jan Leipe
  • O T Burton
  • H Chu
  • Armando Mendez
  • Xiaobo Li
  • Guilan Wang
  • K A Shirey
  • Frank Kirstein
  • Michael J Ripple
  • Seung Ihm Lee
  • M Vargiolu
  • Frank Brombacher
  • K L Limer
  • Andrea Formentini
  • Kazuyo Yamaji-Kegan
  • Shruthi Mohan
  • Sabrina Shandley
  • Raffi Tachdjian
  • Anna Kaminski
  • A Facchini
  • Kazunori Ishige
  • L Pulsatelli
  • Uwe Muller
  • Isabel C J de Faria
  • R Meliconi
  • P Dolzani
  • Haibing Zhang
  • Takeshi Shimamura
  • Kin Wai Lai
  • Sung Il Nam
  • Charles Perkins
  • Maria Isidoro-Garcia
  • T A Chatila
  • Bernd Woitsch
  • Tracy Forster
  • A M Hytönen
  • Claudia Jakubzick
  • Shigetsugu Hatakeyama
  • Dai Takagi
  • Satoshi Fukuda
  • Akihiro Homma
  • Eijiro Nakamura
  • Marta Rubiera
  • Iryna Prots
  • Alla Skapenko
  • Cristina Boada
  • Dolors Giralt
  • Carlos Molina
  • Alejandro Bustamante
  • Victor Llombart
  • Timothy D Howard
  • Markus A Schramm
  • Marc Espadaler
  • Anna Penalba
  • Hendrik Schulze-Koops
  • Joan Montaner
  • Kimberly A Risma
  • T G Jones
  • M Noval-Rivas
  • H C Oettgen
  • A R Darling
  • J S Zhou
  • M F Gurish
  • H Hackstein
  • D Shi
  • L Ma
  • F Yan
  • C P Leo
  • L C Borish
  • M Wang
  • D L Radu
  • C Qin

Detail Information

Publications60

  1. doi IL-4 is proangiogenic in the lung under hypoxic conditions
    Kazuyo Yamaji-Kegan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    J Immunol 182:5469-76. 2009
    ..In conclusion, IL-4 has proangiogenic properties in the lung under hypoxic conditions via the VEGF pathway, and this is independent of the STAT6 pathway...
  2. pmc Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma
    Raffi Tachdjian
    Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Exp Med 206:2191-204. 2009
    ..Our findings indicate that the Q576R polymorphism directly promotes asthma in carrier populations by selectively augmenting IL-4R alpha-dependent signaling...
  3. doi Interleukin-4 receptor polymorphisms in asthma and allergy: relation to different disease phenotypes
    B Hesselmar
    Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden
    Acta Paediatr 99:399-403. 2010
    ..We tested if single nucleotide polymorphisms (SNPs) in the IL4R gene were associated with susceptibility to such diseases, or if they were related to the phenotypic presentation of asthma and allergic rhinoconjunctivitis (ARC)...
  4. pmc Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 70:230-6. 2002
    ..These cytokines also share a common receptor component, IL4R alpha. We have investigated five IL4RA single-nucleotide polymorphisms in a population of Dutch families ascertained through a proband with asthma...
  5. ncbi Haplotypes of the interleukin-4 receptor alpha chain gene associate with susceptibility to and severity of atopic asthma
    A M Hytönen
    Department of Clinical Immunology, Sahlgrenska University Hospital, University of Goteborg, Goteborg, Sweden
    Clin Exp Allergy 34:1570-5. 2004
    ..Several groups have suggested the gene of the IL-4 receptor alpha chain (IL4R) as a candidate gene for the development of asthma, although association with single polymorphisms has shown contradicting results...
  6. ncbi Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms
    Barbara Hoebee
    Laboratory for Health Effects Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 187:2-11. 2003
    ..These results indicate that gain-of-function variants of T helper type 2 cytokine genes may play a role in increasing the severity of RSV disease, which appears more pronounced after the first half-year of life...
  7. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
    ..However, an effect on exacerbations and tissue inflammation has not been shown...
  8. ncbi Association of IL4R gene polymorphisms with asthma in Chinese populations
    Haibing Zhang
    Institute of Health Science, Shanghai Institutes for Biological Sciences of CAS and Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China
    Hum Mutat 28:1046. 2007
    ..00023). Further analysis indicates that these six polymorphisms segregated in strong linkage disequilibrium. The genetic association of IL4R with asthma might provide valuable insights into the pathogenesis of asthma...
  9. ncbi V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function
    Kimberly A Risma
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 169:1604-10. 2002
    ..These data illustrate the importance of studying snps in combination, because the functional significance of a given snp may only be evident in a specific setting of additional snps in the same or different genes...
  10. ncbi The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor
    G K Hershey
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 337:1720-5. 1997
    ..Atopic diseases are very common, and atopy has a strong genetic predisposition...
  11. ncbi Polymorphisms in the IL-4 and IL-4R [alpha] genes and allergic asthma
    Tianpen Cui
    Immunology Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R of China
    Clin Chem Lab Med 41:888-92. 2003
    ..16; p < 0.01), and also total plasma immunoglobulin E (IgE) level was increased in allergic asthma patients. These data suggest that the IL-4R alpha chain 576R/R genotypes confer genetic susceptibility to allergic asthma in Chinese...
  12. doi Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis
    M Vargiolu
    Unità di Genetica Medica, Policlinico Universitario S Orsola Malpighi, Bologna, Italy
    Osteoarthritis Cartilage 18:810-6. 2010
    ..IL-13/IL-4/IL-4R system has strong chondroprotective activity. We investigated polymorphisms in these genes as potential hand osteoarthritis (OA) susceptibility loci by performing a case-control association study...
  13. doi Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study)
    K L Limer
    Department of Public Health and Epidemiology, Nottingham University Medical School, Nottingham NG7 2UH, UK
    Osteoarthritis Cartilage 17:782-9. 2009
    ..Using a new case-control study, our aim was to attempt the replication of findings from 12 genes reported to have significant genetic association with OA and to further examine the role of genetic variation in six of these genes...
  14. doi Oxidative stress regulates IL-4 gene expression in mast cells through the reduction of histone deacetylase
    Yuji Nakamaru
    Department of Otolaryngology Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Otolaryngol Head Neck Surg 152:48-52. 2015
    ..We also examined whether oxidative stress has any impact on HDAC activity...
  15. ncbi Association of interleukin 4 (-590 T/C) and interleukin 4 receptor (Q551R A/G) gene polymorphisms with acne vulgaris
    Ahmad A Al Robaee
    Department of Dermatology, College of Medicine, Qassim University, Saudi Arabia
    Ann Saudi Med 32:349-54. 2012
    ..This study aimed to investigate the association of genetic polymorphisms related to interleukin 4 (IL-4) promotor and receptor (IL-4R) genes as inflammatory modulators with acne vulgaris...
  16. pmc Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy
    O T Burton
    Department of Pediatrics, Boston Children s Hospital, Boston, MA, USA
    Mucosal Immunol 6:740-50. 2013
    ..Our results demonstrate that IL-4-signaling is a key determinant of mast cell expansion in food allergy...
  17. ncbi Common variants in genes that mediate immunity and risk of multiple myeloma
    Elizabeth E Brown
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Int J Cancer 120:2715-22. 2007
    ..Our findings provide preliminary evidence that common genetic variants in specific immune-mediated pathways could influence the risk of MM...
  18. doi Role of beta-defensin 2 and interleukin-4 receptor as stroke outcome biomarkers
    Teresa García-Berrocoso
    Neurovascular Research Laboratory, Vall d Hebron Institute of Research VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Neurochem 129:463-72. 2014
    ..Both biomarkers improve the prediction of poor-outcome over clinical variables in the acute phase of stroke...
  19. doi Increased Th17 cell frequency and poor clinical outcome in rheumatoid arthritis are associated with a genetic variant in the IL4R gene, rs1805010
    Jan Leipe
    Medizinische Klinik and Poliklinik IV, University of Munich, Munich, Germany
    Arthritis Rheumatol 66:1165-75. 2014
    ..The purpose of the present study was to investigate whether rs1805010 modulates Th17 cell development and, hence, subsequent clinical outcome in RA...
  20. ncbi Elevated serum levels of soluble interleukin-4 receptor in osteoarthritis
    T Silvestri
    Laboratorio di Immunologia e Genetica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Osteoarthritis Cartilage 14:717-9. 2006
    ..To test the importance of the interleukin-4 (IL-4)/IL-4 receptor (IL-4R) system in osteoarthritis (OA) we evaluated soluble IL-4R (sIL-4R) levels in sera of patients with different forms of OA and healthy individuals...
  21. ncbi IL4 receptor polymorphism is associated with increased risk of sudden deafness in Korean population
    Sung Il Nam
    Department of Otolaryngology, School of Medicine, Keimyung University, Daegu, Republic of Korea
    Life Sci 78:664-7. 2006
    The interleukin 4 receptor (IL4R) polymorphism Q576R (rs 180275) has been well known to be associated with atopy and other inflammatory diseases...
  22. ncbi Common variants within the interleukin 4 receptor alpha gene (IL4R) are associated with susceptibility to osteoarthritis
    Tracy Forster
    Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, UK
    Hum Genet 114:391-5. 2004
    ..we searched the interval for plausible candidates and concluded that the gene encoding the interleukin 4 receptor alpha chain (IL4R) was a particularly strong candidate based on its known role in cartilage homeostasis...
  23. ncbi Gene interactions and stroke risk in children with sickle cell anemia
    Carolyn Hoppe
    Department of Hematology Oncology, Children s Hospital and Research Center at Oakland, 747 52nd St, Oakland, CA 94609, USA
    Blood 103:2391-6. 2004
    ..If confirmed, these results provide a basis for population screening and targeted intervention to prevent stroke in SCA...
  24. ncbi The role of soluble interleukin-4 receptor and interleukin-5 antibody in preventing late-phase allergy-induced eustachian tube dysfunction
    Hoke W Pollock
    Department of Surgery, Division of Otolaryngology HNS, University of North Carolina Hospitals, Chapel Hill 27599 7070, USA
    Otolaryngol Head Neck Surg 127:169-76. 2002
    ..We investigated the role of soluble interleukin (IL)-4 receptors (sIL-4R) and IL-5 antibodies (IL-5Ab) in preventing allergic eustachian tube dysfunction (ETD) and middle ear effusion (MEE)...
  25. ncbi Interleukin-4-receptor alpha gene polymorphism and the risk of renal cell carcinoma in a South Indian population
    Shruthi Mohan
    Department of Human Genetics, Sri Ramachandra University, Chennai, Tamil Nadu, India
    Asian Pac J Cancer Prev 10:295-8. 2009
    ..Stratified analysis based on the genotypes and the stage of tumor revealed no significant association. Thus, the present study indicates that IL4Ralpha could be a candidate gene for assessing the risk of RCC...
  26. doi Polymorphisms in the IL-13 and IL-4R genes are associated with the development of renal cell carcinoma
    H Chu
    State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Department of Molecular and Genetic Toxicology, School of Public Health, Nanjing Medical University, and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Ann Oncol 23:2114-21. 2012
    ..It has been suggested that the imbalance of immune system of the host might affect the generation of diseases, including cancers...
  27. ncbi Genetic polymorphisms of the interleukin-4 receptor alpha gene are associated with an increasing risk and a poor prognosis of sporadic renal cell carcinoma in a Japanese population
    Eijiro Nakamura
    Department of Urology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Clin Cancer Res 8:2620-5. 2002
    ..The significance of the polymorphisms on the incidence and prognosis in sporadic RCC patients were examined to clarify the role of IL-4 as well as that of the Th1/Th2 immune system in this disease...
  28. pmc Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus
    Louis N Irwin
    Department of Biological Sciences, University of Texas at El Paso, Texas 79968, USA
    Brain Res 1489:1-7. 2012
    ..This suggests considerable variation in the way that olfactory information is processed at the cellular level in different brain regions and by the two sexes...
  29. ncbi Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells
    J G van den Berg
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Am Soc Nephrol 11:413-22. 2000
    ..It is concluded that by binding to specific IL-4/ IL-13 receptors, IL-4 and IL-13 can exert specific effects on GVEC function, which could be of pathogenetic relevance for glomerular injury in MCN...
  30. ncbi Identification of soluble interleukin-4 receptor in rat glomerular epithelial cells(1)
    G Chen
    Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo, Japan
    Biochim Biophys Acta 1452:79-88. 1999
    ..By using this recombinant sIL-4R, we proved that sIL-4R can antagonize the IL-4-induced proliferation of spleen cells. Present study demonstrated that sIL-4R is expressed in kidney cells and antagonistically functional...
  31. ncbi Identification of regulated genes in rat heart after myocardial infarction by means of differential mRNA display
    Y Z Zhu
    Department of Pharmacology, Christian Albrechts University of Kiel, Germany
    Jpn Heart J 41:59-66. 2000
    ..The remaining clones have no similarity to known sequences. These data suggest that certain genes which were not previously being associated with cardiac hypertrophy are turned on during the process of cardiac remodeling after MI...
  32. pmc Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia
    Claudia Jakubzick
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    Am J Pathol 164:1989-2001. 2004
    ....
  33. doi CCL2, CCL18 and sIL-4R in renal, meningeal and pulmonary TB; a 2 year study of patients and contacts
    Armando Mendez
    Universidad Veracruzana, Xalapa, Veracruz, Mexico
    Tuberculosis (Edinb) 91:140-5. 2011
    ..However contacts had raised expression of IL-4δ2 as previously found. These results indicate vigorous and previously unrecorded activity within the Th2 axis, and further investigation is warranted...
  34. doi Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma
    Guilan Wang
    Department of Pediatrics, Zhongshan Boai Hospital, Zhongshan, China
    Sci China Life Sci 53:1215-20. 2010
    ..This suggests that gene therapy is a therapeutic option for treating and controlling chronic airway inflammation and asthma symptoms...
  35. pmc Asthma susceptible genes in Chinese population: a meta-analysis
    Xiaobo Li
    Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
    Respir Res 11:129. 2010
    ..Published data regarding the associations between genetic variants and asthma risk in Chinese population were inconclusive. The aim of this study was to investigate asthma susceptible genes in Chinese population...
  36. pmc Immunomodulation with IL-4R alpha antisense oligonucleotide prevents respiratory syncytial virus-mediated pulmonary disease
    Michael J Ripple
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 185:4804-11. 2010
    ....
  37. doi Endogenous expression of interleukin-4 regulates macrophage activation and confines cavity formation after traumatic spinal cord injury
    Seung Ihm Lee
    Brain Disease Research Center, Institute for Medical Sciences, and Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea
    J Neurosci Res 88:2409-19. 2010
    ..These results suggest that endogenous expression of antiinflammatory cytokine IL-4 regulates the extent of acute macrophage activation and confines the ensuing secondary cavity formation after spinal cord trauma...
  38. pmc Anisakis pegreffii-induced airway hyperresponsiveness is mediated by gamma interferon in the absence of interleukin-4 receptor alpha responsiveness
    Frank Kirstein
    Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Health Sciences Faculty, University of Cape Town and International Centre for Genetic Engineering and Biotechnology ICGEB, 7925 Cape Town, South Africa
    Infect Immun 78:4077-86. 2010
    ..Importantly for diagnosis, allergic airway inflammation can be independent of detectable Anisakis-specific antibodies. Moreover, depending on the route of sensitization, AHR can be induced either by IL-4/IL-13 or by IFN-gamma...
  39. pmc Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent
    K A Shirey
    Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, Baltimore, MD, USA
    Mucosal Immunol 3:291-300. 2010
    ..RSV-infected cotton rats treated with a cyclooxygenase-2 inhibitor increased expression of lung AA-M phi. These data suggest new treatment strategies for RSV that promote AA-M phi differentiation...
  40. ncbi Analysis of interleukin-4 receptor alpha chain variants in multiple sclerosis
    H Hackstein
    Institute of Clinical Immunology and Transfusion Medicine, Justus Liebig University, Langhansstrasse 7, D 35392, Giessen, Germany
    J Neuroimmunol 113:240-8. 2001
    ..These results indicate, that the IL4R variant R551 may influence the genetic predisposition for PPMS but does not represent a general genetic risk factor for MS...
  41. ncbi Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
    L C Borish
    National Jewish Medical and Research Center, University of Colorado, Health Sciences Center, Denver, CO, USA
    J Allergy Clin Immunol 107:963-70. 2001
    ....
  42. ncbi The rat interleukin 4 receptor: coevolution of ligand and receptor
    G Richter
    Institute of Immunology, Klinikum Steglitz, Free University, Berlin, Germany
    Cytokine 7:237-41. 1995
    A rat interleukin 4 receptor (IL-4R) cDNA was cloned by polymerase chain reaction (PCR) using RNA of Con A activated T cells and primers deduced from mouse and human IL-4R sequences...
  43. ncbi Cellular mechanisms involved in experimental insulin-dependent diabetes mellitus
    D L Radu
    Cantacuzino Institute, Department of Immunology Bucharest, Romania
    Roum Arch Microbiol Immunol 60:203-26. 2001
    ..These studies demonstrate that TCR-HA, INS-HA double transgenic mice may provide a useful model to evaluate new strategies for the prevention of diabetes...
  44. ncbi A comprehensive analysis of interleukin-4 receptor polymorphisms and their association with atopy and IgE regulation in childhood
    Bernd Woitsch
    University Children s Hospital Munich, Munich, Germany
    Int Arch Allergy Immunol 135:319-24. 2004
    ..Numerous polymorphisms have been identified in the coding region of the IL4 receptor alpha chain (IL4Ra) and previous association studies have shown conflicting results...
  45. ncbi Analysis of IL4R haplotypes in predisposition to multiple sclerosis
    D B Mirel
    Department of Human Genetics, Roche Molecular Systems, Alameda, CA 94501, USA
    Genes Immun 5:138-41. 2004
    ..009). These findings suggest a potentially important role for the IL4R gene in predisposition to MS, and provide further evidence of its relevance as a candidate gene for immune-related diseases...
  46. pmc Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study
    Maria Isidoro-Garcia
    Department of Medicine, Faculty of Medicine, University of Salamanca, Campus Miguel de Unamuno, Salamanca 37008, Spain
    Clin Mol Allergy 3:15. 2005
    IL4/IL4RA pathway plays an important role in atopy and asthma. Different polymorphisms in IL4 and IL4RA genes have been described. Particularly, -33C>TIL4 and 576Q>RIL4RA SNPs have been independently associated to atopy and asthma...
  47. ncbi IL-4 induces IL-13-independent allergic airway inflammation
    Charles Perkins
    Division of Immunology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Allergy Clin Immunol 118:410-9. 2006
    ..The nonredundant role of IL-13 could reflect unique IL-13 activation of a signaling pathway, inhibitory effects induced by IL-4 but not IL-13, or greater production-potency of IL-13 than IL-4...
  48. ncbi Common variations in the IL4R gene affect splicing and influence natural expression of the soluble isoform
    Ann Marie Bergin
    Department of Clinical Immunology, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Hum Mutat 27:990-8. 2006
    We previously found the soluble interleukin 4 receptor (sIL4R) to be differently expressed in allergic asthma patients compared to healthy individuals. Here we present data demonstrating the involvement of the sequence variations, c...
  49. ncbi Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats
    Kin Wai Lai
    Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Am Soc Nephrol 18:1476-85. 2007
    ....
  50. ncbi Association between Q551R IL4R genetic variants and atopic asthma risk demonstrated by meta-analysis
    Matthew J Loza
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Allergy Clin Immunol 120:578-85. 2007
    ..However, the results from studies testing for associations of the I50V and Q551R IL4R genetic variants are conflicting...
  51. pmc The effects of estrogen and testosterone on gene expression in the rat mesenteric arteries
    Kathleen M Eyster
    Division of Basic Biomedical Science, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA
    Vascul Pharmacol 47:238-47. 2007
    ..3 alpha-hydroxysteroid dehydrogenase, interleukin 4 receptor, JunB and c-Fos expression were increased by estrogen but not by testosterone...
  52. doi Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways
    Anna Kaminski
    Institute of Biomedical and Clinical Science, John Bull Building, Peninsula Medical School, Plymouth, Devon PL6 8BU, UK
    Biosci Rep 30:169-75. 2009
    ..These findings may have implications for future therapeutic strategies for the management of diabetes...
  53. ncbi Interleukin-4 cytotoxin therapy synergizes with gemcitabine in a mouse model of pancreatic ductal adenocarcinoma
    Takeshi Shimamura
    Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH, Bethesda, MD 20892, USA
    Cancer Res 67:9903-12. 2007
    ..These results indicate that IL-4 cytotoxin combined with gemcitabine may provide effective therapy for the treatment of patients with PDA...
  54. doi Association of TGF-beta1, CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents
    Isabel C J de Faria
    Departamento de Genetica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP
    J Pediatr (Rio J) 84:203-10. 2008
    ....
  55. doi Interleukin-13 exerts autocrine growth-promoting effects on human pancreatic cancer, and its expression correlates with a propensity for lymph node metastases
    Andrea Formentini
    Clinic of General, Visceral, and Transplantation Surgery, University of Ulm, Steinhoevelstrasse 9, 89075, Ulm, Germany
    Int J Colorectal Dis 24:57-67. 2009
    ..It is not known whether pancreatic cancer cells produce IL-13 or whether IL-13 can modulate pancreatic cancer cell growth and influence the frequency of lymph node metastases...
  56. doi Potent in vitro and in vivo antitumor activity of interleukin-4-conjugated Pseudomonas exotoxin against human biliary tract carcinoma
    Kazunori Ishige
    Department of Gastroenterology, Institute of Clinical Medicine, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba shi, Ibaraki, Japan
    Int J Cancer 123:2915-22. 2008
    ..5 weeks in treated and untreated mice, respectively). These results indicate that IL-4 receptor-targeted cytotoxin is a potent agent that may provide a new therapeutic option for BTC...
  57. doi A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis
    Uwe Muller
    Institute of Immunology, College of Veterinary Medicine, University of Leipzig, An den Tierkliniken 11, Leipzig, Germany
    J Infect Dis 198:1714-21. 2008
    ..mice and no expression in IL-4Ralpha(-/-) mice, indicating biallelic expression of the gene for IL-4Ralpha (Il4ra)...
  58. ncbi DNA array analysis of changes in preovulatory gene expression in the rat ovary
    C P Leo
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University Medical Center, Stanford, California 94305 5317, USA
    Biol Reprod 65:269-76. 2001
    ..These results demonstrate that DNA arrays can be used to identify genes regulated during the periovulatory period, thus contributing to a more detailed understanding of the molecular mechanisms of ovulation...
  59. pmc IL-4 receptor as a bridge between the immune system and muscle in experimental myasthenia gravis I: up-regulation of muscle IL-15 by IL-4
    Sabrina Shandley
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Clin Immunol 132:246-56. 2009
    ..A model is proposed in which these muscle activities participate in disease progression in experimental myasthenia gravis...

Research Grants5

  1. Inflammation of Myofibroblasts and Loss of Elastic Recoil in Severe Asthma
    Sally E Wenzel; Fiscal Year: 2010
    ..Completing these aims should lead to an improved understanding of the contribution of inflammation and injury repair in the small airways/alveoli to the development of severe asthma. These findings may improve therapy as well. ..
  2. PHASE I/II STUDY OF SIMVASTATIN (ZOCOR) THERAPY IN SICKLE CELL DISEASE
    Carolyn Hoppe; Fiscal Year: 2008
    ..unreadable] [unreadable] 2. To assess the safety and tolerability of oral simvastatin in patients with SCD. [unreadable] [unreadable] [unreadable]..
  3. Gene Expession in Conditioned Taste Aversion
    Louis Irwin; Fiscal Year: 2002
    ..As such, it represents a more realistic view of the way in which a system as complex as the brain likely processes and encodes experiential information. ..
  4. TGF-BETA AND MATRIX METALLOPROTEINASES IN AIRWAY REPAIR
    Sally Wenzel; Fiscal Year: 2002
    ..abstract_text> ..
  5. Th2 effects on eicosanoid pathways: implications for altered innate responses in
    Sally E Wenzel; Fiscal Year: 2010
    ..These three aims should provide new insights into how relationships between innate and adaptive/allergic immune responses influence inflammatory/repair, and finally clinical outcomes in chronic and acute asthma. ..