Il6

Summary

Gene Symbol: Il6
Description: interleukin 6
Alias: ILg6, Ifnb2, interleukin-6, IL-6, Interleukin 6 (interferon, beta 2)
Species: rat

Top Publications

  1. ncbi Induction and regulation of interleukin-6 gene expression in rat astrocytes
    E N Benveniste
    Department of Neurology, University of Alabama, Birmingham 35294
    J Neuroimmunol 30:201-12. 1990
  2. ncbi Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjögren's syndrome and correlate with the clinical manifestations of the disease
    J Hulkkonen
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    Rheumatology (Oxford) 40:656-61. 2001
  3. pmc Interleukin-6 regulates pancreatic alpha-cell mass expansion
    Helga Ellingsgaard
    Division of Endocrinology and Diabetes and Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 105:13163-8. 2008
  4. doi Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK
    Xiao Qin Wang
    Department of Physiology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong 226001, China
    Neurosci Lett 450:122-6. 2009
  5. doi Bilateral changes in IL-6 protein, but not in its receptor gp130, in rat dorsal root ganglia following sciatic nerve ligature
    Vaclav Brazda
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic
    Cell Mol Neurobiol 29:1053-62. 2009
  6. pmc Expression of IL-1alpha, IL-6, TGF-beta, FasL and ZNF265 during sertoli cell infection by ureaplasma urealyticum
    Rongping Li
    Shanghai Jiao Tong University School of Medicine, Department of Immunology, Shanghai Institute of Immunology, Shanghai 200025, China
    Cell Mol Immunol 6:215-21. 2009
  7. doi Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Neuron Glia Biol 6:73-83. 2010
  8. doi Neuroprotection of interleukin-6 against NMDA-induced apoptosis and its signal-transduction mechanisms
    Zhan Liu
    Department of Physiology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong, China
    Neurotox Res 19:484-95. 2011
  9. doi Habitual physical exercise improves macrophage IL-6 and TNF-α deregulated release in the obese zucker rat model of the metabolic syndrome
    Leticia Martín-Cordero
    Departamento de Fisiologia, Grupo de Investigación de Inmunofisiología, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Espana
    Neuroimmunomodulation 18:123-30. 2011
  10. doi IL-6/IL-6 receptor system and its role in physiological and pathological conditions
    Masahiko Mihara
    Fuji Gotemba Research Laboratories, Product Research Department, Chugai Pharmaceutical Co Ltd, Gotemba, Japan
    Clin Sci (Lond) 122:143-59. 2012

Research Grants

  1. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
  2. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  3. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  4. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
  5. NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONS
    Catherine Rivier; Fiscal Year: 2004
  6. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2008
  7. CELLULAR INTERACTIONS IN PULMONARY OXYGEN TOXICITY
    ANBUKILI CHETTY; Fiscal Year: 2006
  8. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
  9. Cell-targeting peptide nucleic acids for hormone-refractory prostate cancer
    Beverly Barton; Fiscal Year: 2008
  10. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009

Detail Information

Publications157 found, 100 shown here

  1. ncbi Induction and regulation of interleukin-6 gene expression in rat astrocytes
    E N Benveniste
    Department of Neurology, University of Alabama, Birmingham 35294
    J Neuroimmunol 30:201-12. 1990
    ..IL-6 may act to promote terminal differentiation of B cells in the CNS, leading to immunoglobulin synthesis...
  2. ncbi Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjögren's syndrome and correlate with the clinical manifestations of the disease
    J Hulkkonen
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    Rheumatology (Oxford) 40:656-61. 2001
    To determine whether plasma interleukin-6 (IL-6) and G/C base exchange polymorphism at position -174 of the IL6 gene have an effect on the clinical manifestations of primary Sjögren's syndrome (pSS).
  3. pmc Interleukin-6 regulates pancreatic alpha-cell mass expansion
    Helga Ellingsgaard
    Division of Endocrinology and Diabetes and Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 105:13163-8. 2008
    ....
  4. doi Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK
    Xiao Qin Wang
    Department of Physiology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong 226001, China
    Neurosci Lett 450:122-6. 2009
    ..These findings suggest that IL-6 protects neurons from NMDA-induced excitoxicity and the IL-6 neuroprotection may be transduced by both JAK/STAT3 and RAS/MAPK pathways...
  5. doi Bilateral changes in IL-6 protein, but not in its receptor gp130, in rat dorsal root ganglia following sciatic nerve ligature
    Vaclav Brazda
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic
    Cell Mol Neurobiol 29:1053-62. 2009
    ..The data provide evidence for changes in IL-6 levels not only in the DRG associated with the damaged nerve but also in those unassociated with nerve injury during the experimental neuropathic pain model...
  6. pmc Expression of IL-1alpha, IL-6, TGF-beta, FasL and ZNF265 during sertoli cell infection by ureaplasma urealyticum
    Rongping Li
    Shanghai Jiao Tong University School of Medicine, Department of Immunology, Shanghai Institute of Immunology, Shanghai 200025, China
    Cell Mol Immunol 6:215-21. 2009
    ..The trend of varied expression of ZNF265 was similar to those of TGF-beta and FasL in vitro and in vivo for Sertoli cells infected with UU...
  7. doi Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Neuron Glia Biol 6:73-83. 2010
    ..The results may suggest that unilateral CCI of the sciatic nerve induces bilateral activation of SGC in L4-L5 DRG to transduce IL-6 signalling during neuroinflammation...
  8. doi Neuroprotection of interleukin-6 against NMDA-induced apoptosis and its signal-transduction mechanisms
    Zhan Liu
    Department of Physiology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong, China
    Neurotox Res 19:484-95. 2011
    ..These results suggest that IL-6 protects neurons against NMDA-induced apoptosis, and that the IL-6 neuroprotection is jointly mediated by JAK-STAT3 and PI3K-Akt signaling pathways...
  9. doi Habitual physical exercise improves macrophage IL-6 and TNF-α deregulated release in the obese zucker rat model of the metabolic syndrome
    Leticia Martín-Cordero
    Departamento de Fisiologia, Grupo de Investigación de Inmunofisiología, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Espana
    Neuroimmunomodulation 18:123-30. 2011
    ..The second purpose was to evaluate in the obese rats the effects of habitual exercise and of a bout of acute exercise on the observed MS-associated deregulation in the release of TNF-α and IL-6 by peritoneal macrophages...
  10. doi IL-6/IL-6 receptor system and its role in physiological and pathological conditions
    Masahiko Mihara
    Fuji Gotemba Research Laboratories, Product Research Department, Chugai Pharmaceutical Co Ltd, Gotemba, Japan
    Clin Sci (Lond) 122:143-59. 2012
    ..In the present review, we first summarize the IL-6/IL-6R system and IL-6 signal transduction, and then go on to discuss the physiological and pathological roles of IL-6...
  11. doi Loss of occludin expression and impairment of blood-testis barrier permeability in rats with autoimmune orchitis: effect of interleukin 6 on Sertoli cell tight junctions
    Cecilia Valeria Pérez
    Instituto de Investigaciones Biomedicas, Universidad de Buenos Aires, Buenos Aires, Argentina
    Biol Reprod 87:122. 2012
    ..The role of IL6 as modulator of tight junction dynamics was also evaluated because intratesticular content of this cytokine is ..
  12. pmc Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve
    Petr Dubovy
    Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, Brno, 62500, Czech Republic
    J Neuroinflammation 10:55. 2013
    ..Current research implicates interleukin (IL)-6 as a key component of the nervous-system response to injury with various effects...
  13. ncbi Interleukin 6 and its soluble receptor are elevated in aqueous humor of patients with uveitis
    J Petrinović-Doresić
    General Hospital Sveti Duh Department of Ophthalmology
    Ocul Immunol Inflamm 7:75-84. 1999
    To determine the levels of interleukin 6 (IL-6) and its soluble receptor (sIL-6R) in the aqueous humor (AH) of patients with different uveitis entities.
  14. ncbi Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca
    S C Pflugfelder
    Ocular Surface and Tear Center Bascom Palmer Eye Institute University of Miami School of Medicine Department of Ophthalmology Miami, FL 33136, USA
    Curr Eye Res 19:201-11. 1999
    ..To compare epidermal growth factor (EGF) concentration in tear fluid and levels of inflammatory cytokines in the conjunctival epithelium of patients with Sjögren's syndrome keratoconjunctivitis sicca with those of normal controls...
  15. ncbi Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome
    J C Bensadoun
    Division of Surgical Research and Gene Therapy Center, Lausanne Medical School, Pavillon 4, CHUV, 1011 Lausanne, Switzerland
    Eur J Neurosci 14:1753-61. 2001
    ..Interleukin-6, another member of the cytokine family, and the chimeric molecule (IL6/IL6R) in which interleukin-6 and its soluble receptor are fused, have been shown to exert trophic action on various ..
  16. ncbi [Serum levels of interleukin 6 (IL-6) and soluble IL-6 receptor (sIL-6R) in children and adolescents with Graves-Basedow disease]
    A Bossowski
    Klinika Chorób Dzieci AM, Ul Waszyngtona 17, 15 274 Białystok
    Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw 5:85-93. 1999
    The concentration of interleukin 6 (IL-6), soluble IL-6 receptor (sIL-6R) and intercellular adhesion molecule-1 (sICAM-1) was assayed in 24 children with Graves' disease, aged 6...
  17. ncbi Oxidative stress stimulates IL-4 and IL-6 production in mast cells by an APE/Ref-1-dependent pathway
    Barbara Frossi
    Dipartimento di Scienze e Tecnologie Biomediche, Universita Degli Studi di Udine, Udine, Italy
    Eur J Immunol 33:2168-77. 2003
    ..Nonetheless, H(2)O(2) and FcepsilonRI signalings are additive in augmenting IL-4 production. Most importantly, oxidative stress can induce a pro-type 2 inflammatory response from mast cells that is independent of FcepsilonRI stimulation...
  18. pmc Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes
    Xin Wen Yu
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    J Physiol 566:327-40. 2005
    ..Thus, these results suggest that activation of iNOS mediates IL-6-induced inhibition of SR function in ARVM during chronic exposure...
  19. pmc Intestinal inflammation-induced growth retardation acts through IL-6 in rats and depends on the -174 IL-6 G/C polymorphism in children
    Andrew Sawczenko
    Research Centre for Gastroenterology, Institute of Cell and Molecular Science, University of London, London E1 2AD, United Kingdom
    Proc Natl Acad Sci U S A 102:13260-5. 2005
    ..028). However, their risk of developing Crohn's disease was similar to other genotypes when compared with 351 healthy controls (P = 0.7). Thus, the IL-6 -174 genotype mediates growth failure in children with Crohn's disease...
  20. pmc The interleukin-6 gene -174G>C and -572G>C promoter polymorphisms are related to cerebral aneurysms
    L Morgan
    The Victor Horsley Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 77:915-7. 2006
    ..The hypothesis that there is an association of the proinflammatory cytokine interleukin-6 (IL-6) genotypes (-572G>C and -174G>C) with intracranial aneurysms was tested...
  21. ncbi Immunoglobulin preparations attenuate organ dysfunction and hemostatic abnormality by suppressing the production of cytokines in lipopolysaccharide-induced disseminated intravascular coagulation in rats
    Hidesaku Asakura
    Department of Internal Medicine III, Kanazawa University School of Medicine, Ishikawa, Japan
    Crit Care Med 34:2421-5. 2006
    ..We attempted to clarify the effect of immunoglobulin concentrates on the rat lipopolysaccharide (LPS)-induced disseminated intravascular coagulation (DIC) model...
  22. ncbi No interplay between the pathways mediating coagulation and inflammation in tissue factor-induced disseminated intravascular coagulation in rats
    Yasuo Ontachi
    Department of Internal Medicine III, Kanazawa University School of Medicine, Japan
    Crit Care Med 34:2646-50. 2006
    ....
  23. ncbi [The assessment of the correlation between vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF-alpha), interleukin 6 (IL-6), glycaemic control (HbA1c) and the development of the diabetic retinopathy in children with diabetes mellitus typ
    Małgorzata Myśliwiec
    Kliniki Pediatrii, Hematologii, Onkologii i Endokrynologii Akademii Medycznej w Gdańsku
    Klin Oczna 109:150-4. 2007
    ....
  24. ncbi The proinflammatory cytokine tumor necrosis factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6
    Nerea Roher
    Departament de Fisiologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Endocrinology 149:1880-9. 2008
    ....
  25. doi The role of IL-6 and IL-11 in hyperoxic injury in developing lung
    Anne Chetty
    Department of Pediatrics, Floating Hospital for Children, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Pediatr Pulmonol 43:297-304. 2008
    ..IL-11 and IL-6 provide protective effects against oxidant-mediated injury in fetal type II cells and IL-11 provides protection in vivo by down-regulation of caspase-mediated cell death...
  26. doi Combination therapy with renin-angiotensin system inhibitors and the calcium channel blocker azelnidipine decreases plasma inflammatory markers and urinary oxidative stress markers in patients with diabetic nephropathy
    Susumu Ogawa
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Hospital, Aoba ku, Sendai, Japan
    Hypertens Res 31:1147-55. 2008
    ....
  27. ncbi Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes
    Midori Kurohara
    Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Japan
    Kobe J Med Sci 54:E1-13. 2008
    ..In conclusion, low-dose warfarin is a potential immunomodulator which can prevent autoimmune diabetes...
  28. doi Increased levels of proinflammatory cytokines in the aged rat brain attenuate injury-induced cytokine response after excitotoxic damage
    O Campuzano
    Medical Histology, Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Autonomous University of Barcelona, Bellaterra, Spain
    J Neurosci Res 87:2484-97. 2009
    ..This study highlights the particular inflammatory response of the aged brain and suggests an important role of increased basal levels of proinflammatory cytokines in the reduced ability to induce their expression after damage...
  29. doi IL-6-trans-signalling increases rapid-eye-movement sleep in rats
    Ulrike May
    Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    Eur J Pharmacol 613:141-5. 2009
    b>Interleukin 6 (IL-6), a cytokine of the gp130-signalling-family, plays an important role in immediate immunological functions, in metabolism and in the central nervous system...
  30. doi Functional implication of BAFF synthesis and release in gangliosides-stimulated microglia
    Kwang Soo Kim
    Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea
    J Leukoc Biol 86:349-59. 2009
    ..These findings imply that BAFF secreted by microglia may play important roles in CNS inflammation by regulating microglia as well as infiltrated B cells...
  31. pmc Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates
    Gareth J Hathway
    UCL Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Pain 144:110-8. 2009
    ..These results demonstrate that a brief period of low frequency C-fibre stimulation, in the absence of nerve damage, is sufficient to activate microglia resulting in behavioural hyperalgesia...
  32. doi A new regulation of IL-6 production in adult cardiomyocytes by beta-adrenergic and IL-1 beta receptors and induction of cellular hypertrophy by IL-6 trans-signalling
    Nicolas Szabo-Fresnais
    INSERM UMR S 769, F 92296, Chatenay Malabry, France
    Cell Signal 22:1143-52. 2010
    ..The IL-6 soluble receptor may thus serve as a switch for IL-6 to activate STAT3 phosphorylation and hypertrophy...
  33. doi Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart
    Youde Jiang
    Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Can J Physiol Pharmacol 88:553-61. 2010
    ....
  34. pmc Tissue-derived proinflammatory effect of adenosine A2B receptor in lung ischemia-reperfusion injury
    Farshad Anvari
    Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 140:871-7. 2010
    ..This study tests the hypothesis that the adenosine A(2B) receptor exacerbates the proinflammatory response to lung ischemia-reperfusion injury...
  35. pmc Elevated maternal soluble Gp130 and IL-6 levels and reduced Gp130 and SOCS-3 expressions in women complicated with preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, LSUHSC Shreveport, Shreveport, LA 71130, USA
    Hypertension 57:336-42. 2011
    ..Thus, reduced gp130 and SOCS-3 expressions may offer, at least in part, a plausible explanation of reduced antiinflammatory protection in the maternal vascular system in preeclampsia...
  36. doi Activation of a pro-survival pathway IL-6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin-induced differentiation of C6 malignant glioma cells
    Minfeng Shu
    Department of Pharmacology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, PR China
    Mol Oncol 5:265-72. 2011
    ....
  37. pmc The social environment and IL-6 in rats and humans
    Katherine B Saxton
    School of Public Health, University of California, Berkeley, CA 94720, United States
    Brain Behav Immun 25:1617-25. 2011
    ..Adversity early in life may not have a monotonically negative effect on adult health, but may alter biological sensitivity to later social experiences...
  38. pmc Excessive food intake, obesity and inflammation process in Zucker fa/fa rat pancreatic islets
    Myriam Chentouf
    Centre National de la Recherche Scientifique Formation de Recherche en Evolution 3400, Centre de Pharmacologie et Innovation pour le Diabète, Faculte de Pharmacie, Montpellier, France
    PLoS ONE 6:e22954. 2011
    ..That the latter could contribute to β-cell hyperactivity/proliferation and possibly lead to progressive β-cell failure in these animals, deserves further investigations...
  39. pmc Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
    Simon A Jones
    Department of Infection, Immunity and Biochemistry, The School of Medicine, Cardiff University, Cardiff, United Kingdom
    J Clin Invest 121:3375-83. 2011
    ..Attention will be given to the role of the soluble IL-6R, and we will provide a perspective into the clinical blockade of IL-6 activity in autoimmunity, inflammation, and cancer...
  40. doi Vascular endothelial growth factor and interleukin-6 are correlated with serous retinal detachment in central retinal vein occlusion
    Hidetaka Noma
    Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women s Medical University, Chiba, Japan
    Curr Eye Res 37:62-7. 2012
    ..To investigate aqueous humour and vitreous fluid levels of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) in patients with central retinal vein occlusion (CRVO) and serous retinal detachment...
  41. doi The roles of aerobic exercise training and suppression IL-6 gene expression by RNA interference in the development of insulin resistance
    Hui Tang
    Department of Physical Education, Hunan University of Science and Technology, Xiangtan, Hunan Province, China
    Cytokine 61:394-405. 2013
    ..To demonstrate the hypothesis that aerobic exercise training inhibits the development of insulin resistance through IL-6 and probe into the possible molecular mechanism about it...
  42. doi The effect of ischemic precondition to IL-6 on rat liver ischemia-reperfusion injury in transplantation
    Lin Zhong Cui
    Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510000, Guangdong Province, China
    Asian Pac J Trop Med 6:395-9. 2013
    ..To investigate the effect of ischemic precondition to protect ischemia-reperfusion injury and reduce IL-6 expression in the rats liver transplantation...
  43. pmc Interleukin-6 downregulation with mesenchymal stem cell differentiation results in loss of immunoprivilege
    Peng Li
    Department of Cardiac Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Division of Cardiovascular Surgery and Toronto General Research Institute, University Health Network and Department of Surgery, Division of Cardiac Surgery, University of Toronto, Toronto, ON, Canada
    J Cell Mol Med 17:1136-45. 2013
    ..These findings suggest that rejection of allogeneic MSCs after implantation may be because of a reduction in cellular IL-6 levels, and restoration of IL-6 may be a new target to retain MSC immunoprivilege. ..
  44. doi Dynamic expression of the suppressor of cytokine signaling-3 and cytokines in the cerebral basilar artery of rats with subarachnoid hemorrhage, and the effect of acetylcholine
    Jin ning Song
    Department of Neurosurgery, The First Affiliated Hospital, Medical School of Xi an Jiaotong University, Xi an, Shaanxi, People s Republic of China
    Acta Neurochir (Wien) 156:941-9; discussion 949. 2014
    ..Therefore, we aimed to describe and clarify the dynamic expression of SOCS-3 and cytokines after SAH, as well as the relationships between the levels of SOCS-3, cytokines, and ACh...
  45. doi IL-6 up-regulates the expression of rat LH receptors during granulosa cell differentiation
    Fumiharu Imai
    Department of Obstetrics and Gynecology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Endocrinology 155:1436-44. 2014
    ..These results suggest that IL-6 up-regulates FSH-induced LHR production by increasing mRNA transcription, and JAK/signal transducer and activator of transcription 3 signaling is required for up-regulation by IL-6 in granulosa cells. ..
  46. pmc Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF- β in rat strains with different susceptibilities to experimental autoimmune encephalomyelitis
    Tanja Grubić-Kezele
    Department of Physiology and Immunology, Medical Faculty, University of Rijeka, B Branchetta 22, 51 000 Rijeka, Croatia
    Clin Dev Immunol 2013:750406. 2013
    ....
  47. doi Severe acute pancreatitis: a possible role of intramyocardial cytokine production
    Alberto Meyer
    Department of Gastroenterology LIM 37, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    JOP 15:237-42. 2014
    ..The aim was to evaluate local myocardial cytokine production, as well as, functional and histological myocardial alterations in severe acute pancreatitis...
  48. pmc Tumour necrosis factor, interleukin-6 and interleukin-10 are possibly involved in Plasmodium vivax-associated thrombocytopaenia in southern Pakistani population
    Afsheen Raza
    Department of Pathology and Microbiology, Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    Malar J 13:323. 2014
    ..vivax-induced thrombocytopaenia. However, study on correlation of cytokines and thrombocytopaenia in P. vivax, particularly in patients with severe signs and symptoms has not been reported from Pakistan...
  49. doi Sporothrix schenckii yeasts induce ERK pathway activation and secretion of IL-6 and TNF-α in rat mast cells, but no degranulation
    Yolanda Romo-Lozano
    Departamento de Microbiologia, Centro de Ciencias Basicas, Universidad Autonoma de Aguascalientes, Aguascalientes, Mexico
    Med Mycol 52:862-8. 2014
    ..schenckii infection...
  50. pmc Effects of Nogo-A Silencing on TNF-α and IL-6 Secretion and TH Downregulation in Lipopolysaccharide-Stimulated PC12 Cells
    Jianbin Zhong
    Neurology Department, People s Hospital of Zengcheng City Boji Hospital Affiliated to Sun Yat sen University, Guangzhou 511300, China
    Biomed Res Int 2015:817914. 2015
    ..Nogo-A silencing might provide new ideas for PD treatment in the future. ..
  51. doi TLR2/NFκB signalling regulates endogenous IL-6 release from marrow-derived mesenchymal stromal cells to suppress the apoptosis of PC12 cells injured by oxygen and glucose deprivation
    Xia Shi
    Children s Nutrition Research Centre, Children s Hospital of Chongqing Medical University, Chongqing 400014, P R China
    Mol Med Rep 13:5358-64. 2016
    ..The present study has reported a novel immunomodulatory effect of the microenvironment of neural damage during MSC cytotherapy. ..
  52. ncbi [Changes of alveolar macrophage phagocytosis and TNF-alpha, IL-6 of rats with Pneumocystis pneumonia]
    Zhi min Lu
    Department of Parasitology, Hebei North University, Zhangjiakou 075000, China
    Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 23:428-30. 2011
    ..To observe the changes of alveolar macrophage (AM) phagocytosis and the levels of TNF-alpha and IL-6 in AM supernatants and bronchoalveolar lavage fluid (BALF) of rats with Pneumocystis pneumonia (PCP)...
  53. pmc Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylate
    Youngchul Kim
    Division of Liver Diseases, Department of Medicine, The Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Liver Int 32:1008-17. 2012
    ..The hepatic stellate cell (HSC) is a key target of anti-fibrotic therapies. Imatinib mesylate is a small molecule receptor tyrosine kinase inhibitor indicated for treatment of chronic myelogenous leukaemia and GI stromal tumours...
  54. pmc Lentiviral vector-mediated down-regulation of IL-17A receptor in hepatic stellate cells results in decreased secretion of IL-6
    Sheng Chu Zhang
    Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
    World J Gastroenterol 18:3696-704. 2012
    ..To investigate the mechanism of interleukin (IL)-6 secretion through blocking the IL-17A/IL-17A receptor (IL-17RA) signaling pathway with a short hairpin RNA (shRNA) in hepatic stellate cells (HSCs) in vitro...
  55. pmc Mitigation of isolation-associated adipocyte interleukin-6 secretion following rapid dissociation of adipose tissue
    Airlia C S Thompson
    Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA
    J Lipid Res 53:2797-805. 2012
    ....
  56. ncbi Interleukin 6 mediated differentiation and rescue of cell redox in PC12 cells exposed to ionizing radiation
    K Abeyama
    Department of Laboratory Medicine, Faculty of Medicine, Kagoshima University, Japan
    FEBS Lett 364:298-300. 1995
    ..Increases in the DNA binding activity of nuclear factor kappa B (NF-kappa B) and increased Interleukin 6 (IL-6) mRNA levels were observed at a dose of 15 Gy...
  57. ncbi Differential expression of TNF-alpha, IL-6, and IGF-1 by graded mechanical stress in normal rat myocardium
    Emiliano A Palmieri
    Department of Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, L Califano Facoltà di Medcina e Chirurgia, Universita degli Studi di Napoli Federico II, Naples, Italy
    Am J Physiol Heart Circ Physiol 282:H926-34. 2002
    ..Such findings may have potential implications with regard to compensatory hypertrophy and failure...
  58. ncbi Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis
    Susan E Malley
    University of Vermont, College of Medicine, Department of Neurology, Burlington, Vermont 05405, USA
    Physiol Genomics 9:5-13. 2002
    ..Increased cytokine expression after CYP-induced cystitis, alone or in combination with other inflammatory mediators or growth factors, may contribute to altered lower urinary tract function after cystitis...
  59. pmc The role of endotoxin, TNF-alpha, and IL-6 in inducing the state of growth hormone insensitivity
    Ping Wang
    Research Institute of General Surgery, Jinling Hospital, 305 Zhong Shan East Road, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 8:531-6. 2002
    ..The objective of this current study was to investigate the role of endotoxin, TNF-alpha and IL-6 in inducing the growth hormone insensitivity at the receptor and post-receptor levels...
  60. ncbi Expression of leukemia inhibitory factor (LIF)/interleukin-6 family cytokines and receptors during in vitro osteogenesis: differential regulation by dexamethasone and LIF
    F Liu
    INSERM U403, Hopital E Herriot, Lyon, France
    Bone 31:212-9. 2002
    ....
  61. ncbi Interleukin-6 gene expression is increased in insulin-resistant rat skeletal muscle following insulin stimulation
    A L Carey
    Department of Physiology, The University of Melbourne, Parkville 3010, Vic, Australia
    Biochem Biophys Res Commun 302:837-40. 2003
    ..It is likely that the differences observed when comparing healthy with insulin resistant muscle are due to the differential activation of insulin sensitive signalling proteins responsible for activating IL-6...
  62. pmc Principles of interleukin (IL)-6-type cytokine signalling and its regulation
    Peter C Heinrich
    Institut fur Biochemie, RWTH Aachen, Universitatsklinikum, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Biochem J 374:1-20. 2003
    ..Also the cross-talk between the JAK/STAT pathway with other signalling cascades is discussed...
  63. ncbi Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Shock 19:538-46. 2003
    ..Collectively these data indicate that skeletal muscle possesses many of the components of the innate immune system, including increases in both early- and late-phase cytokines and the presence of toll-like receptors...
  64. ncbi Hypothalamic interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Endocrinology 144:4868-75. 2003
    ..These results strongly suggest that IL-1 beta and TNF-alpha may represent the major proinflammatory cytokines mediating the LPS-induced suppression of GnRH and LH release, whereas the role of IL-6 seems to be insignificant...
  65. ncbi Diagnostic role of serum interleukin 6 and CA 19-9 in patients with cholangiocarcinoma
    Pisit Tangkijvanich
    Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Hepatogastroenterology 51:15-9. 2004
    ..The first marker represents the commonly used serum marker in cholangiocarcinoma and the second marker is a multi-functional cytokine associated with cancer development...
  66. ncbi Interleukin-6: a cytokine to forget
    D Balschun
    Leibniz Institute for Neurobiology, Magdeburg, Germany
    FASEB J 18:1788-90. 2004
    ..In view of the suggested role of LTP in memory formation, these data implicate IL-6 in the mechanisms controlling the kinetics and amount of information storage...
  67. ncbi Mechanism of cardiac depression after trauma-hemorrhage: increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac function
    Shaolong Yang
    Center for Surgical Research, The Univ of Alabama at Birmingham, 1670 Univ Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Heart Circ Physiol 287:H2183-91. 2004
    ..Thus there is an inverse correlation between cardiomyocyte IL-6 levels and cardiac function after T-H. The salutary effects of E2 on cardiac function after T-H may be due in part to decreased IL-6 synthesis in cardiomyocytes...
  68. ncbi Interleukin-6, interleukin-8, and soluble tumor necrosis factor receptor-I in the cord blood as predictors of chronic lung disease in premature infants
    Hiromi An
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Japan
    Am J Obstet Gynecol 191:1649-54. 2004
    ..In order to predict the late-development of chronic lung disease of prematurity (CLD), cytokines in the cord blood were assessed in this study...
  69. ncbi AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway
    Roser Gorina
    Departament de Farmacologia i Toxicologia, IIBB CSIC, IDIBAPS, Rossello 161, Planta 6, 08036 Barcelona, Spain
    J Neurochem 92:505-18. 2005
    ....
  70. pmc Fibre-type specificity of interleukin-6 gene transcription during muscle contraction in rat: association with calcineurin activity
    Sébastien Banzet
    Department of Human Factors, Centre de Recherches du Service de Sante des Armees, BP 87, 38702 La Tronche Cedex, France
    J Physiol 566:839-47. 2005
    ..Our data clearly suggest that IL-6 gene transcription was mainly observed in early recruited myofibres and that contraction-induced IL-6 transcription could be associated with enhanced calcineurin activity...
  71. ncbi Interleukin-6 in neurons of the pterygopalatine ganglion of the rat
    I G Charyeva
    Department of Morphology, Russian State Medical University, Moscow
    Neurosci Behav Physiol 35:465-7. 2005
    ....
  72. ncbi The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia
    H Ashdown
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Montreal, Quebec, Canada H4H 1R3
    Mol Psychiatry 11:47-55. 2006
    ..Collectively, these data suggest that effects of maternal LPS exposure on the developing fetal brain are not mediated by the direct action of LPS, but via indirect actions at the level of the maternal circulation or placenta...
  73. ncbi Depolarization-induced slow Ca2+ transients stimulate transcription of IL-6 gene in skeletal muscle cells
    Nevenka Juretic
    Programa de Biologia Celular y Molecular, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 70086 Santiago 7, Santiago, Chile
    Am J Physiol Cell Physiol 290:C1428-36. 2006
    ..Our results provide evidence for involvement of IP(3)-mediated Ca(2+) signals on IL-6 transcription in skeletal muscle cells...
  74. ncbi The systemic inflammatory response to exercise in adults with cystic fibrosis
    Alina A Ionescu
    Respiratory Medicine, Cardiff University, Academic Centre, Llandough Hospital, Cardiff, CF64 2XX, United Kingdom
    J Cyst Fibros 5:105-12. 2006
    ..We report greater increments in circulating concentrations of some cytokines with moderate exercise in adults with cystic fibrosis compared to healthy subjects...
  75. ncbi Activation of the JAK-STAT signaling pathway in the rat basilar artery after subarachnoid hemorrhage
    Koji Osuka
    Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Brain Res 1072:1-7. 2006
    ..These results indicate that SAH produces the proinflammatory cytokine IL-6 in the CSF, which activates the JAK-STAT signaling pathway in the basilar artery and induces transcription of immediate early genes...
  76. ncbi Interleukin-6 g.-174G>C promoter polymorphism is associated with obesity in the EPIC-Potsdam Study
    Kerstin Klipstein-Grobusch
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal
    Obesity (Silver Spring) 14:14-8. 2006
    ..044) and was most pronounced in subjects with the CC genotype, suggesting that the IL-6 g.-174G>C promoter polymorphism is a susceptibility or modifying locus for common obesity and weight gain...
  77. ncbi IL-6 is constitutively expressed during lung morphogenesis and enhances fetal lung explant branching
    Cristina Nogueira-Silva
    Fetal and Neonatal Physiology, Life and Health Sciences Research Institute ICVS, University of Minho, 4709 057 Braga, Portugal
    Pediatr Res 60:530-6. 2006
    ..IL-6 enhanced p38-MAPK phosphorylation without changing MEK1/2 and JNK pathways. The present study suggests a physiological role for IL-6 on pulmonary branching mechanisms most likely involving p38-MAPK intracellular signalling pathway...
  78. ncbi Up regulation of IL-6 by ischemic preconditioning in normal and fatty rat livers: association with reduction of oxidative stress
    Lorenza Tacchini
    Institute of General Pathology, University of Milano, Via Mangiagalli 31, 20133, Milano, Italy
    Free Radic Res 40:1206-17. 2006
    ..In conclusion, IP modulates the activity of transcription factors and triggers IL-6 production; this may prevent hepatic I/R damage in a oxidative stress-dependent way, particularly in fatty livers...
  79. ncbi Contraction-induced interleukin-6 transcription in rat slow-type muscle is partly dependent on calcineurin activation
    Sébastien Banzet
    Department of Human Factors, Centre de Recherches du Service de Sante des Armees, La Tronche, France
    J Cell Physiol 210:596-601. 2007
    ..Taken together, these results demonstrate that in addition to p38 MAPK, increased calcineurin activity is one of the signalling events involved in IL-6 gene transcription...
  80. ncbi HB-EGF induces delayed STAT3 activation via NF-kappaB mediated IL-6 secretion in vascular smooth muscle cell
    Kuy Sook Lee
    Center for Biomedical Sciences, Division of Cardiovascular Diseases, National Institute of Health, Seoul, Korea
    Biochim Biophys Acta 1773:1637-44. 2007
    ..In conclusion, IL-6 plays an important role in the delayed activation of STAT3 and VSMC proliferation induced by HB-EGF...
  81. pmc Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury
    Kathleen D Liu
    Division of Nephrology, University of California, San Francisco, CA, USA
    Crit Care Med 35:2755-61. 2007
    ..To identify biological and clinical predictors of acute kidney injury in subjects with acute lung injury...
  82. ncbi [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers]
    Hyun Ho Joo
    Department of Surgery, Inje University Pusan Paik Hospital, Inje University College of Medicine, Busanjin Gu, Busan, Korea
    Korean J Gastroenterol 50:370-8. 2007
    ..We aimed to analyze the expressions of each marker and their relationships with clinicopathologic factors...
  83. doi TNFalpha antagonist upregulates interleukin-6 in rats with hypertensive heart failure
    Espen Haugen
    Department of Molecular and Clinical Medicine and Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Sweden
    Int J Cardiol 130:64-8. 2008
    ..Hypertension is one of most common causes to chronic heart failure in humans...
  84. doi Interleukin-6, TNF-alpha and interleukin-1 beta levels in blood and tissue in severely burned rats
    Diane Agay
    Centre de Recherches du Service de Sante des Armees, 24 Avenue des Maquis du Gresivaudan, BP87, 38702 La Tronche Cedex, France
    Eur Cytokine Netw 19:1-7. 2008
    ....
  85. doi Intrinsic catch-up growth of hypoplastic fetal lungs is mediated by interleukin-6
    Cristina Nogueira-Silva
    Life and Health Sciences Research Institute, ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Pediatr Pulmonol 43:680-9. 2008
    ....
  86. doi Psychological stress induces hypoferremia through the IL-6-hepcidin axis in rats
    Min Zhao
    Department of Naval Medicine, Second Military Medical University, 800 Xiangxin Road, Shanghai 200433, PR China
    Biochem Biophys Res Commun 373:90-3. 2008
    ..These changes were blocked by the injection of IL-6 monoclonal antibody. In conclusion, the IL-6-hepcidin axis is up-regulated by psychological stress in rats, resulting in hypoferremia and increase of hepatic iron storage...
  87. pmc Gamma-aminobutyric acid inhibits synergistic interleukin-6 release but not transcriptional activation in astrocytoma cells
    Joseph D Roach
    Department of Chemistry, University of Nevada, Las Vegas, Nevada 89154 4003, USA
    Neuroimmunomodulation 15:117-24. 2008
    ..We investigated the GABA-mediated suppression of the synergistic release of interleukin (IL)-6 due to interleukin 1-beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha)...
  88. doi Particle-induced cytokine responses in cardiac cell cultures--the effect of particles versus soluble mediators released by particle-exposed lung cells
    Annike I Totlandsdal
    Department of Air Pollution and Noise, Division of Environmental Medicine, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Toxicol Sci 106:233-41. 2008
    ..These in vitro findings lend support to the hypothesis that particle-induced cardiac inflammation and disease may involve lung-derived mediators...
  89. doi [Effects of Quyu Jiedu Granule on expressions of tumor necrosis factor-alpha and interleukin-6 mRNAs in ovarian granulosa cells of endometriosis rats]
    Xin Ling Li
    Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250014, China
    Zhong Xi Yi Jie He Xue Bao 6:960-3. 2008
    ....
  90. pmc Sepsis-induced inflammation is exacerbated in an animal model of type 2 diabetes
    Asha Jacob
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center and The Feinstein Institute for Medical Research Manhasset, NY 11030, USA
    Int J Clin Exp Med 1:22-31. 2008
    ..These studies suggest that sepsis-induced inflammation is exacerbated in an animal model of Type 2 diabetes...
  91. doi The -174G>C IL-6 gene promoter polymorphism and diabetic microvascular complications
    G Rudofsky
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Horm Metab Res 41:308-13. 2009
    ..In conclusion these data suggest no major influence of the -174G>C variant in the promoter region of the IL-6 gene on the development of microvascular complications in patients with diabetes...
  92. pmc alpha1-Adrenergic receptor stimulates interleukin-6 expression and secretion through both mRNA stability and transcriptional regulation: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB
    Dianne M Perez
    Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mol Pharmacol 76:144-52. 2009
    ..Our results indicate that alpha(1)-ARs stimulated IL-6 expression and secretion through regulating both mRNA transcription and stability, involving p38 MAPK and NF-kappaB pathways...
  93. doi Pre-existing lipopolysaccharide may increase the risk of heatstroke in rats
    Xiao Jing Lin
    Department of Nursing, Nanfang Hospital, Southern University, Guangzhou, Guangdong, China
    Am J Med Sci 337:265-70. 2009
    ..We attempted to ascertain whether pre-existing inflammatory state [caused by exogenous administration of lipopolysaccharide (LPS)] exacerbated multiorgan dysfunction in experimental heatstroke...
  94. doi Switch from a dominant Th1-associated immune profile during the pre-diabetic phase in favour of a temporary increase of a Th3-associated and inflammatory immune profile at the onset of type 1 diabetes
    Anna Ryden
    Division of Paediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Diabetes Metab Res Rev 25:335-43. 2009
    ..Further, to follow the immune response from onset to 2 years duration, the study focused on spontaneous as well as autoantigen-induced immune profile...
  95. doi Interleukin-6 increases intracellular Ca2+ concentration and induces catecholamine secretion in rat carotid body glomus cells
    Juan Fan
    Institute of Neurosciences, Fourth Military Medical University, Xi an, Shaanxi, China
    J Neurosci Res 87:2757-62. 2009
    ..Our experiments provide further evidence for the responsiveness of the CB to proinflammatory cytokines and indicate that the CB might play a role in inflammation sensing and transmission of such information to the brain...
  96. doi Low-grade inflammation can partly explain the association between the metabolic syndrome and either coronary artery disease or severity of peripheral arterial disease: the CODAM study
    M Jacobs
    Laboratory for Metabolism and Vascular Medicine, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Invest 39:437-44. 2009
    ..The aim was to study whether the association between the metabolic syndrome and CAD or the severity of PAD can be explained by low-grade inflammation...
  97. doi Post-ischemic hypothermia for 24h in P7 rats rescues hippocampal neuron: association with decreased astrocyte activation and inflammatory cytokine expression
    Man Xiong
    Key Laboratory of Neonatal Diseases, Ministry of Health, Children s Hospital, Fudan University, 399 Wanyuan Road, Shanghai 201102, China
    Brain Res Bull 79:351-7. 2009
    ..The present findings highlight an apparent association between inhibition of hippocampal neuron loss by hypothermia and decreased astrocytosis and inflammatory cytokine release after hypoxia-ischemia in the developing brain...
  98. doi High weight differences between donor and recipient affect early kidney graft function--a role for enhanced IL-6 signaling
    W Gong
    Institute of Medical Immunology, Charite University Medicine, Campus Mitte, Berlin, Germany
    Am J Transplant 9:1742-51. 2009
    ..These findings have strong clinical implication as anti-IL6R treatment of patients receiving grafts from lower-weight donors could be used to improve primary graft function...
  99. doi Interleukin-6 is associated with liver lipid homeostasis but not with cell death in experimental hepatic steatosis
    Miguel A Sánchez-Garrido
    Reina Sofia University Hospital, Cordoba, Spain
    Innate Immun 15:337-49. 2009
    ..Furthermore, PC is identified as a new survival agent that reverses several TNFalpha-inducible responses that are likely to promote steatosis and necrosis...

Research Grants13

  1. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  2. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  3. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  4. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  5. NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONS
    Catherine Rivier; Fiscal Year: 2004
    ..Collectively, these results will provide novel and comprehensive information regarding the neurocircuitries through which NO or CO modulate the response of the rat HPA to a neurogenic stress. ..
  6. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2008
    ..Collectively, these studies will advance our understanding of the effects of alcohol on male reproductive functions and the mechanisms that mediate them. ..
  7. CELLULAR INTERACTIONS IN PULMONARY OXYGEN TOXICITY
    ANBUKILI CHETTY; Fiscal Year: 2006
    ..This mentored work will provide extensive education and technical experience in Molecular Biology and the development of a model of hyperoxic lung injury. ..
  8. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
    ..abstract_text> ..
  9. Cell-targeting peptide nucleic acids for hormone-refractory prostate cancer
    Beverly Barton; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009
    ..Results obtained from the proposed work should enhance our knowledge and establish a direct link of placental TC activity and EC dysfunction in PE. ..
  11. Communication between Kupffer cells and stellate cells
    Natalia Nieto; Fiscal Year: 2009
    ..We hope that this co-culture model will help us to define the effects of Kupffer cells on the stellate cell fibrogenic response and to dissect potential therapeutic targets for preventing liver disease. ..
  12. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2010
    ..The influence of CLP on placental sFlt-1 will be studied. Results obtained from the proposed work should enhance current knowledge of the role of the placenta and EC dysfunction in the pathogenesis of PE. ..
  13. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..