Il1b

Summary

Gene Symbol: Il1b
Description: interleukin 1 beta
Alias: IL-1F2, interleukin-1 beta, IL-1 beta
Species: rat

Top Publications

  1. pmc Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor
    Pablo Pelegrin
    Department of Biomedical Science, University of Sheffield, Sheffield, UK
    EMBO J 25:5071-82. 2006
  2. pmc Chronic neuropathic pain-like behavior correlates with IL-1β expression and disrupts cytokine interactions in the hippocampus
    Adriana del Rey
    Department of Immunophysiology, Institute of Physiology and Pathophysiology, Medical Faculty, 35037 Marburg, Germany
    Pain 152:2827-35. 2011
  3. ncbi Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus
    Aine Kelly
    Trinity College Institute of Neuroscience, Department of Physiology, Dublin 2, Ireland
    J Biol Chem 278:19453-62. 2003
  4. pmc IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
    J A Ehses
    Division of Endocrinology, Diabetes, and Nutrition and Center for Integrated Human Physiology, University Hospital of Zurich, 8045 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:13998-4003. 2009
  5. pmc Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction
    Liqi Tong
    University of California Irvine, Institute for Brain Aging and Dementia, Irvine, CA 92697 4540, USA
    Neurobiol Aging 29:1380-93. 2008
  6. ncbi Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade
    J A Frank
    Cardiovascular Research Institute, University of California, San Francisco VA Medical Center, 4150 Clement St, Box 111D, San Francisco, CA 94121, USA
    Thorax 63:147-53. 2008
  7. doi Expression of IL-1beta, MMP-9 and TIMP-1 on the pressure side of gingiva under orthodontic loading
    Tae Yeon Lee
    Department of Orthodontics, College of Dentistry, Yonsei University, Seoul, South Korea
    Angle Orthod 79:733-9. 2009
  8. ncbi Interleukin-1 beta modulates AMPA receptor expression and phosphorylation in hippocampal neurons
    Aaron Y Lai
    Department of Psychiatry, Neurochemical Research Unit, University of Alberta, Canada
    J Neuroimmunol 175:97-106. 2006
  9. doi Regulation of interleukin-1beta by the interleukin-1 receptor antagonist in the glutamate-injured spinal cord: endogenous neuroprotection
    Song Liu
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Brain Res 1231:63-74. 2008
  10. pmc Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1
    Julia Lichtnekert
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    PLoS ONE 6:e26778. 2011

Research Grants

  1. Effects of Acupuncture on Bone Cancer Pain in Mice
    Ruixin Zhang; Fiscal Year: 2004
  2. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2005
  3. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2009
  4. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
  5. Melanocortins, Energy Balance and Cancer Anorexia
    Brent Wisse; Fiscal Year: 2006
  6. VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURY
    James Frank; Fiscal Year: 2006
  7. MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSIS
    Deborah Carlson; Fiscal Year: 2006

Detail Information

Publications195 found, 100 shown here

  1. pmc Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor
    Pablo Pelegrin
    Department of Biomedical Science, University of Sheffield, Sheffield, UK
    EMBO J 25:5071-82. 2006
    ....
  2. pmc Chronic neuropathic pain-like behavior correlates with IL-1β expression and disrupts cytokine interactions in the hippocampus
    Adriana del Rey
    Department of Immunophysiology, Institute of Physiology and Pathophysiology, Medical Faculty, 35037 Marburg, Germany
    Pain 152:2827-35. 2011
    ....
  3. ncbi Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus
    Aine Kelly
    Trinity College Institute of Neuroscience, Department of Physiology, Dublin 2, Ireland
    J Biol Chem 278:19453-62. 2003
    ..The evidence is consistent with the idea that the LPS-induced impairment in LTP is mediated by IL-1 beta and is a consequence of activation of p38...
  4. pmc IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
    J A Ehses
    Division of Endocrinology, Diabetes, and Nutrition and Center for Integrated Human Physiology, University Hospital of Zurich, 8045 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:13998-4003. 2009
    ..Rather than being directly cytotoxic, IL-1beta may drive tissue inflammation that impacts on both beta cell functional mass and insulin sensitivity in type 2 diabetes...
  5. pmc Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction
    Liqi Tong
    University of California Irvine, Institute for Brain Aging and Dementia, Irvine, CA 92697 4540, USA
    Neurobiol Aging 29:1380-93. 2008
    ..These results suggest that IL-1 beta places neurons at risk by interfering with BDNF signaling involving a ceramide-associated mechanism...
  6. ncbi Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade
    J A Frank
    Cardiovascular Research Institute, University of California, San Francisco VA Medical Center, 4150 Clement St, Box 111D, San Francisco, CA 94121, USA
    Thorax 63:147-53. 2008
    ..A study was undertaken to determine if IL-1 signalling is a necessary early event in the pathogenesis of experimental ventilator-induced lung injury...
  7. doi Expression of IL-1beta, MMP-9 and TIMP-1 on the pressure side of gingiva under orthodontic loading
    Tae Yeon Lee
    Department of Orthodontics, College of Dentistry, Yonsei University, Seoul, South Korea
    Angle Orthod 79:733-9. 2009
    ..To test the hypothesis that orthodontic pressure does not induce gene transcription of IL-1beta, MMP-9, and TIMP-1 in pressure gingival soft tissue...
  8. ncbi Interleukin-1 beta modulates AMPA receptor expression and phosphorylation in hippocampal neurons
    Aaron Y Lai
    Department of Psychiatry, Neurochemical Research Unit, University of Alberta, Canada
    J Neuroimmunol 175:97-106. 2006
    ..These findings suggest that IL-1beta selectively regulates AMPA receptor phosphorylation and surface expression through extracellular calcium and an unknown mechanism involving NMDA receptor activity...
  9. doi Regulation of interleukin-1beta by the interleukin-1 receptor antagonist in the glutamate-injured spinal cord: endogenous neuroprotection
    Song Liu
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Brain Res 1231:63-74. 2008
    ..Our results demonstrate that IL-1beta contributes to glutamate damage following SCI; blocking IL-1beta may usefully counteract glutamate toxicity...
  10. pmc Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1
    Julia Lichtnekert
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    PLoS ONE 6:e26778. 2011
    ..Together, the NLRP3-ASC-caspase-1 axis does not contribute to intrinsic glomerular inflammation via glomerular parenchymal cells as these cannot produce IL-1β during sterile inflammation...
  11. pmc LPS-induced release of IL-6 from glia modulates production of IL-1β in a JAK2-dependent manner
    Aedin M Minogue
    Trinity College Institute for Neuroscience, Lloyd Building, University of Dublin, Trinity College, College Green, Dublin 2, Ireland
    J Neuroinflammation 9:126. 2012
    ..We sought to identify signaling kinases responsible for cytokine production and to delineate the complex interactions which govern time-related responses to lipopolysaccharide (LPS)...
  12. pmc Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats
    Ruth M Barrientos
    Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    J Neurosci 32:14641-8. 2012
    ..Furthermore, the long-lasting presence of IL-1RA in the brain (4 d) compared with in the blood (<24 h) underscores the value of intracisternal administration of IL-1RA for therapeutic purposes...
  13. ncbi Interleukin-1 beta induction of neuron apoptosis depends on p38 mitogen-activated protein kinase activity after spinal cord injury
    Xin jia Wang
    Department of Spine Surgery, The Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China
    Acta Pharmacol Sin 26:934-42. 2005
    ....
  14. doi Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription
    Bo Wang
    Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
    Arterioscler Thromb Vasc Biol 30:536-45. 2010
    ..EGR-1 autoregulation, and histone modification in the EGR-1 promoter, represent key mechanisms in EGR-1 control, but have not been explored...
  15. doi Differences in the relative involvement of peripherally released interleukin (IL)-6, brain IL-1β and prostanoids in mediating lipopolysaccharide-induced fever and sickness behavior
    Lois M Harden
    School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg, South Africa
    Psychoneuroendocrinology 36:608-22. 2011
    ....
  16. doi Anxiety-like behavior in the elevated-plus maze tests and enhanced IL-1β, IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats
    Martina Skurlova
    Department of Normal, Pathological, and Clinical Physiology, Charles University in Prague, 120 00 Prague, Czech Republic
    Neurosci Lett 487:250-4. 2011
    ....
  17. ncbi Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1 beta expression in a rat model
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Anesth Analg 105:1482-8, table of contents. 2007
    ....
  18. doi Interleukin 1 beta gene promoter SNPs are associated with risk of pancreatic cancer
    Rainer Hamacher
    Technische Universität of München, II Medizinische Klinik, Klinikum rechts der Isar, Ismaninger Str 22, 81675 Munich, Germany
    Cytokine 46:182-6. 2009
    ..These findings provide a first evidence for an association of the IL1beta gene promoter SNPs with risk for pancreatic cancer...
  19. doi Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy
    Won Ho Hahn
    Department of Pediatrics, East West Kidney Diseases Research Institute, School of Medicine, Kyung Hee University, Dondaemun gu, Hoegi dong 1, Seoul, 130 701, Korea
    Pediatr Nephrol 24:1329-36. 2009
    ..SNPs of the IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (RN) genes (IL1A, IL1B, and IL1RN, respectively) were analyzed in 182 patients with childhood IgAN and in 500 healthy controls...
  20. doi Serum levels of IL-1β, IL-6 and TNF-α in rats fed with Kashin-Beck disease-affected diet
    Denglu Yan
    Orthopedic Department West China Hospital of Sichuan University, Chengdu, Sichuan, China
    Int J Rheum Dis 13:406-11. 2010
    ..To investigate the serum level of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in rats which have been fed with Kashin-Beck disease (KBD) epidemic district food...
  21. ncbi Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways
    Ralph Andre
    School of Biological Sciences, 1 124 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Neuroreport 16:153-7. 2005
    ..These data suggest that the differential effects of IL-1alpha and IL-1beta on glial cells are mediated by alternative pathways to the classical IL-1 signalling cascade...
  22. ncbi Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism
    Emmanuel Pinteaux
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, UK
    J Neurochem 102:826-33. 2007
    ..These results confirm our earlier observations in vivo and demonstrate that microglia are an important source of IL-1beta in the brain in response to leptin...
  23. doi Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in Lewis rats
    Andrea Stofkova
    Department of Normal, Pathological, and Clinical Physiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
    Neuroimmunomodulation 16:377-84. 2009
    ..Since IL-1beta is involved in the central induction of anorexia, we studied its expression in the nARC as well...
  24. doi High glucose and interleukin-1beta downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism
    Célia Aveleira
    Center of Ophthalmology and Vision Sciences, Institute of Biomedical Research in Light and Image, University of Coimbra, Portugal
    Cytokine 49:279-86. 2010
    ..The downregulation of IL-1RI is triggered by its activation and is due, at least partially, to lysosomal degradation. High glucose and IL-1beta also enhance the translocation of IL-1RI to the nucleus...
  25. doi Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes
    K Luotola
    Department of Medicine, Helsinki University Hospital, Helsinki, Finland
    J Intern Med 269:322-32. 2011
    ..We further examined whether genetic variants at the interleukin-1 (IL-1) locus would predict clinically incident diabetes...
  26. doi Lipopolysaccharide-induced nigral inflammation leads to increased IL-1β tissue content and expression of astrocytic glial cell line-derived neurotrophic factor
    Mahmoud M Iravani
    Neurodegenerative Disease Research Centre, Institute of Pharmaceutical Sciences, School of Biomedical Sciences, King s College London, SE1 1UL London, UK
    Neurosci Lett 510:138-42. 2012
    ..The results suggest that inflammation is not only involved in neuronal loss but could promote neuronal survival through increased release of GDNF following up-regulation of IL-1β...
  27. pmc Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke
    Karsten Ruscher
    Department of Clinical Sciences, Division of Neurosurgery, Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    PLoS ONE 7:e45118. 2012
    ..Treatment did not affect the increased levels of the pro-inflammatory cytokines interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interleukin 4 (IL-4), interleukin ..
  28. doi Interleukin-6, TNF-alpha and interleukin-1 beta levels in blood and tissue in severely burned rats
    Diane Agay
    Centre de Recherches du Service de Sante des Armees, 24 Avenue des Maquis du Gresivaudan, BP87, 38702 La Tronche Cedex, France
    Eur Cytokine Netw 19:1-7. 2008
    ....
  29. pmc Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}
    Lei Diao
    From the Department of Pharmacokinetics, Dynamics, and Drug Metabolism, Pfizer Global Research and Development, Groton Laboratories, Pfizer Inc, Groton, Connecticut 06340
    J Biol Chem 285:31185-92. 2010
    ....
  30. doi TNF-α and IL-1β mediate Japanese encephalitis virus-induced RANTES gene expression in astrocytes
    Chun Jung Chen
    Department of Education and Research, Taichung Veterans General Hospital, Taichung 407, Taiwan
    Neurochem Int 58:234-42. 2011
    ..The released RANTES from glial cells might play a role in the recruitment of immune cells during JEV infection...
  31. doi Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1β pro-inflammatory effects
    Alice De Corato
    Institute of Pharmacology, Catholic University Medical School, L go F Vito 1, Rome, Italy
    J Neuroimmunol 237:39-46. 2011
    ..CGRP effects were reverted by a specific CGRP receptor antagonist and mimicked by elevation of intracellular cAMP levels. CGRP exerted also minor proinflammatory effects on cortical astrocytes...
  32. doi Oligomers of β-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1β, tumour necrosis factor-α, and a nuclear factor κ-B mechanism in the rat brain
    I Carrero
    Laboratory of Neuroanatomy, Institute of Neuroscience of Castilla and Leon, Valladolid University Campus of Soria, Spain
    Exp Neurol 236:215-27. 2012
    ....
  33. ncbi Hypothalamic interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Endocrinology 144:4868-75. 2003
    ..These results strongly suggest that IL-1 beta and TNF-alpha may represent the major proinflammatory cytokines mediating the LPS-induced suppression of GnRH and LH release, whereas the role of IL-6 seems to be insignificant...
  34. ncbi Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats
    R D McCall
    Department of Internal Medicine, University of North Carolina at Chapel Hill
    Gastroenterology 106:960-72. 1994
    ..Cecal interleukin 1 (IL-1) and IL-1 receptor antagonist (IL-1ra) expression was measured in inbred rats displaying differential susceptibility to experimental enterocolitis...
  35. doi Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities
    Franciszek Burdan
    Experimental Teratology Unit of the Human Anatomy Department, Medical University of Lublin, Lublin, Poland
    Folia Histochem Cytobiol 48:30-6. 2010
    ..It could be concluded that abnormal expression of the selected interleukins is associated with low placental weight and decrease of its thickness, especially labyrinth zone, as well as with high maternal urea level...
  36. doi Differential expression of pro-inflammatory cytokines, endothelin-1 and nitric oxide synthases in the rat carotid body exposed to intermittent hypoxia
    Rodrigo Del Rio
    Laboratorio de Neurobiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Brain Res 1395:74-85. 2011
    ..Thus, present results suggest that the local expression of chemosensory modulators and pro-inflammatory cytokines in the CB may have different temporal contribution to the CB chemosensory potentiation induced by CIH...
  37. ncbi Allergic rhinitis and polymorphisms of the interleukin 1 gene complex
    Veli Pekka Joki-Erkkilä
    Department of Otorhinolaryngology, Tampere University Hospital, Tampere, Finland
    Ann Allergy Asthma Immunol 91:275-9. 2003
    ..Allergic rhinitis is a chronic inflammatory disease with a genetic background. Inflammatory reactions are regulated by cytokines. Cytokine genes are polymorphic and have been implicated as candidate genes in allergy...
  38. ncbi [The expression of mucosal IL-1β, TNFα and serotonin transporter in chronic visceral hypersensitivity rats]
    Yan Chi
    Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China
    Zhonghua Nei Ke Za Zhi 49:781-4. 2010
    ....
  39. doi Association of interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Turkish children with atopic asthma
    Dost Zeyrek
    Division of Allergy and Pulmonology, Department of Pediatrics, Aegean University School of Medicine, Izmir, Turkey
    Allergy Asthma Proc 29:468-74. 2008
    ..Based on these findings, it has been proposed that IL-1beta -511C/T and IL-Ra intron 2 gene polymorphism are useful markers for prediction of asthma...
  40. doi Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis
    Rafael L Pereira
    Departamento de Medicina, Laboratório de Imunologia Clínica e Experimental, Disciplina de Nefrologia, Universidade Federal de Sao Paulo, Brazil
    Kidney Int 79:1217-27. 2011
    ..Thus, we propose that kinin has a crucial role in the pathogenesis of FSGS operating through bradykinin B1 receptor signaling...
  41. ncbi Interleukin-1 mediates endothelin-1-induced fever and prostaglandin production in the preoptic area of rats
    Aline S C Fabricio
    Institute of Pharmacology, Catholic University Medical School, Largo F Vito 1 00168 Rome, Italy
    Am J Physiol Regul Integr Comp Physiol 290:R1515-23. 2006
    ..In conclusion, our results show that ET-1 increases IL-1 production in the POA, and this effect appears to be correlated to ET-1-induced fever in vivo, as well as to PG production in vitro...
  42. doi Expressions of interleukin-1β and interleukin-6 within aortas and uteri of rats with various severities of ligature-induced periodontitis
    Shouzhi Ma
    School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian 350002, People s Republic of China
    Inflammation 34:260-8. 2011
    ....
  43. pmc Functional role for interleukin-1 in the injured peripheral taste system
    Liqiao Shi
    Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, GA 30912 3000, USA
    J Neurosci Res 90:816-30. 2012
    ..Cytokine actions in the taste system are largely unstudied. These results demonstrate that IL-1 has a beneficial effect on taste function after nearby injury, in contrast to its detrimental role in the injured central nervous system...
  44. ncbi Interleukin-1beta exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures
    Nils P Hailer
    Dr Senckenbergische Anatomie, Institute of Anatomy 2, Johann Wolfgang Goethe University, D 60590 Frankfurt am Main, Federal Republic of Germany
    Eur J Neurosci 21:2347-60. 2005
    ....
  45. ncbi Extracellular signal-regulated kinase-mediated IL-1-induced cortical neuron damage during traumatic brain injury
    Kwok Tung Lu
    Department of Life Science, National Taiwan Normal University, Taipei, Taiwan
    Neurosci Lett 386:40-5. 2005
    ..Our results suggest that TBI-induced cortical neuron death was mediated by the IL-1 receptor through ERK phosphorylation...
  46. ncbi Effect of interleukin-1 on traumatic brain injury-induced damage to hippocampal neurons
    Kwok Tung Lu
    Department of Life Science, National Taiwan Normal University, Taipei, Taiwan
    J Neurotrauma 22:885-95. 2005
    ..These results show that IL-1alpha and IL-1beta play important roles in the TBI-induced loss of hippocampal neurons...
  47. ncbi C-reactive protein levels and common polymorphisms of the interleukin-1 gene cluster and interleukin-6 gene in patients with coronary heart disease
    G Latkovskis
    Latvian Centre of Cardiology, P Stradins Clinical University Hospital, Riga
    Eur J Immunogenet 31:207-13. 2004
    ..Our data also suggest a possible relationship of IL-1RN(VNTR)*2 with lower CRP levels in the same patients...
  48. doi Contribution of IL-1 to resistance to Streptococcus pneumoniae infection
    Daniel Kafka
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva 84101, Israel
    Int Immunol 20:1139-46. 2008
    ..pneumoniae infection and suggest that IL-1beta has a major role in resistance to primary pneumococcal infection while the role of IL-1alpha is less important...
  49. ncbi IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 15:483-90. 2003
    ..These observations indicate that IL-1 plays important roles in the development of AHR...
  50. ncbi Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone
    Jung Won Park
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 30:830-6. 2004
    ..In summary, acute exposure to O(3) induces AHR, neutrophilic inflammation, epithelial damage, and IL-1. An IL-1Ra effectively prevents the development of altered airway function, inflammation, and structural damage...
  51. ncbi Heme oxygenase-1 attenuates interleukin-1beta-induced nitric oxide synthase expression in vascular smooth muscle cells
    Nian Chung Yang
    Division of Cardiovascular Research, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC
    J Biomed Sci 11:799-809. 2004
    ..CO appears to mediate the suppressive effect of HO-1, at least in part, through downregulating transcriptional activation of the iNOS gene via a cGMP-dependent pathway...
  52. ncbi Interleukin-1 alpha, interleukin-1 beta, and tumor necrosis factor gene expression in endotoxin-induced uveitis
    M Yoshida
    Department of Ophthalmology, Kyoto University Faculty of Medicine, Japan
    Invest Ophthalmol Vis Sci 35:1107-13. 1994
    ..To localize and determine the levels of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta), and tumor necrosis factor (TNF) gene expression in the process of endotoxin-induced uveitis (EIU) in rats...
  53. ncbi Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells
    Jose M Vela
    Neural Plasticity Unit, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Avenida Doctor Arce 37, Madrid, Spain
    Mol Cell Neurosci 20:489-502. 2002
    ..These results support a role for IL-1beta in promoting mitotic arrest and differentiation of oligodendrocyte progenitors as well as maturation and survival of differentiating oligodendrocytes...
  54. pmc Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway
    Yuekui Li
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurosci 23:1605-11. 2003
    ....
  55. ncbi Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases
    B Viviani
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Neurosci 23:8692-700. 2003
    ..These data suggest that IL-1beta increases NMDA receptor function through activation of tyrosine kinases and subsequent NR2A/B subunit phosphorylation. These effects may contribute to glutamate-mediated neurodegeneration...
  56. ncbi Interleukin-1beta enhances NMDA receptor-mediated current but inhibits excitatory synaptic transmission
    Sheng Yang
    Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Haidian District, Beijing 100850, China
    Brain Res 1034:172-9. 2005
    ..These data suggest that IL-1beta modulates hippocampus-related functions via its effect on synaptic activity and Ca2+ signaling in neurons...
  57. ncbi Peripheral inflammation modifies the effect of intrathecal IL-1beta on spinal PGE2 production mainly through cyclooxygenase-2 activity. A spinal microdialysis study in freely moving rats
    Lin Shi
    Department of Anesthesiology, Academic Hospital of Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    Pain 120:307-14. 2006
    ..Our study suggests that mainly the COX-2 enzyme mediates the IL-1beta-induced increase in spinal PGE(2) in the presence of peripheral formalin inflammation...
  58. ncbi Suppression of cell proliferation by interferon-alpha through interleukin-1 production in adult rat dentate gyrus
    Naoko Kaneko
    Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Nakakoma gun, Yamanashi, Japan
    Neuropsychopharmacology 31:2619-26. 2006
    ..The decreased cell proliferation caused by IFN-alpha-induced IL-1beta may be responsible, at least in part, for IFN-alpha-induced depression...
  59. pmc IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pain 135:232-9. 2008
    ..05) and inhibited NR1 phosphorylation compared to saline control. The results suggest that spinal IL-1beta is produced by astrocytes and enhances NR1 phosphorylation to facilitate inflammatory pain...
  60. ncbi Interleukin-1beta mediates proliferation and differentiation of multipotent neural precursor cells through the activation of SAPK/JNK pathway
    Xiaofei Wang
    Department of Neurobiology, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, PR China
    Mol Cell Neurosci 36:343-54. 2007
    ..These findings collectively suggest that the inflammatory environment following CNS injuries may influence the ability of NPCs to repair the damage...
  61. ncbi Interleukin-1beta enhances the effect of serum deprivation on rat annular cell apoptosis
    Chang Qing Zhao
    Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China
    Apoptosis 12:2155-61. 2007
    ....
  62. ncbi IL-1beta promotes neurite outgrowth by deactivating RhoA via p38 MAPK pathway
    Ko Temporin
    Department of Orthopaedics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 365:375-80. 2008
    ..These findings suggest that IL-1beta may contribute to nerve regeneration by promoting neurite outgrowth following nerve injury...
  63. pmc Interleukin-1-induced interleukin-6 synthesis is mediated by the neutral sphingomyelinase/Src kinase pathway in neurones
    N Tsakiri
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Br J Pharmacol 153:775-83. 2008
    ....
  64. pmc IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress
    Ja Wook Koo
    Department of Psychology, Yale University, New Haven, CT 06520 8205, USA
    Proc Natl Acad Sci U S A 105:751-6. 2008
    ..These findings demonstrate that IL-1beta is a critical mediator of the antineurogenic and depressive-like behavior caused by acute and chronic stress...
  65. doi The IL-1 family: regulators of immunity
    John E Sims
    Amgen, 1201 Amgen Court West, Seattle, Washington 98119, USA
    Nat Rev Immunol 10:89-102. 2010
    ..This Review provides an overview of both the long-established and more recently characterized members of the IL-1 family. In addition to their effects on immune cells, their involvement in human disease and disease models is discussed...
  66. doi A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells
    Holly F Green
    Department of Anatomy and Neuroscience, University College Cork, Ireland
    Mol Cell Neurosci 49:311-21. 2012
    ....
  67. doi Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway
    Michela Miani
    Laboratory of Experimental Medicine, Erasmus Hospital, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    Endocrinology 153:3017-28. 2012
    ..These observations link β-cell ER stress to the triggering of exacerbated local inflammation...
  68. doi GSK-3 mediates the release of IL-1β, TNF-α and IL-10 from cortical glia
    Holly F Green
    Department of Anatomy and Neuroscience, University College Cork, Ireland
    Neurochem Int 61:666-71. 2012
    ..These results demonstrate a role for GSK-3 as a modulator of inflammatory cytokine levels in the brain, and contribute to a mechanistic insight into neurological disorders in which neuroinflammation is a characteristic feature...
  69. ncbi Interleukin-1 expression during hyperoxic lung injury in the mouse
    B Piedboeuf
    Unité de Recherche de Pédiatrie, Centre de Recherche du CHUL, Centre Hospitalier Universitaire de Quebec, Ste Foy, Canada
    Free Radic Biol Med 24:1446-54. 1998
    ..However, it is not known whether increased synthesis of IL-1beta or the uncoupling of IL-1beta protein and mRNA accumulation has a role in pathophysiology of pulmonary O2 toxicity...
  70. ncbi Activated peripheral blood and endothelial cells in thalassemia patients
    D S Kyriakou
    Department of Hematology, University Hospital of Heraklion, Crete, Greece
    Ann Hematol 80:577-83. 2001
    ..We studied cell surface antigens on peripheral blood cells associated with the activation of these cells and soluble molecules produced by activated endothelium...
  71. ncbi Time of day differences in IL1beta and TNFalpha mRNA levels in specific regions of the rat brain
    Cassia Cearley
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, College of Veterinary Medicine, PO Box 646520, Pullman, WA 99164 6520, USA
    Neurosci Lett 352:61-3. 2003
    ..Time-of-day differences in TNFalpha mRNA levels were observed in all these brain regions. These results support the hypothesis that TNFalpha and IL1beta have physiological roles within the brain...
  72. ncbi A biphasic role of nuclear transcription factor (NF)-kappaB in the islet beta-cell apoptosis induced by interleukin (IL)-1beta
    Gianpaolo Papaccio
    Department of Experimental Medicine, Laboratory of Histology and Embriology, 2nd University of Naples, Naples, Italy
    J Cell Physiol 204:124-30. 2005
    ..Furthermore, when the IL-1beta stress impairs islet beta-cell function, NF-kappaB activation regulates the entrance of islet beta-cell into the cell death program...
  73. ncbi Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol
    Lea Sarov-Blat
    University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, K1Y 4W7, Canada
    Arterioscler Thromb Vasc Biol 27:1115-22. 2007
    ..Reduced plasma concentrations of high-density lipoprotein-cholesterol (HDL-C) are a significant risk factor for cardiovascular disease. Mechanisms that regulate HDL-C concentrations represent an important area of investigation...
  74. doi Increased levels of proinflammatory cytokines in the aged rat brain attenuate injury-induced cytokine response after excitotoxic damage
    O Campuzano
    Medical Histology, Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Autonomous University of Barcelona, Bellaterra, Spain
    J Neurosci Res 87:2484-97. 2009
    ..This study highlights the particular inflammatory response of the aged brain and suggests an important role of increased basal levels of proinflammatory cytokines in the reduced ability to induce their expression after damage...
  75. pmc IL1B polymorphisms modulate cystic fibrosis lung disease
    Hara Levy
    Division of Pulmonary Medicine, Children s Hospital, Boston, MA, USA
    Pediatr Pulmonol 44:580-93. 2009
    ....
  76. ncbi Stress-induced changes of interleukin-1beta within the limbic system in the rat
    E Badowska-Szalewska
    Deaprtment of Anatomy and Neurobiology, Medical University of Gdansk, Poland
    Folia Morphol (Warsz) 68:119-28. 2009
    ..These data demonstrate that only the levels of IL-1beta-ir in juvenile rat brains are affected by FS and OF. Additionally, there was no significant difference between FS and OF stimulation in IL-1beta-ir...
  77. doi Multiple antioxidants and L-arginine modulate inflammation and dyslipidemia in chronic renal failure rats
    Aida A Korish
    Department of Physiology, Faculty of Medicine, King Saud University, Saudi Arabia
    Ren Fail 32:203-13. 2010
    ..Indeed, the effects of L-arginine and the antioxidants on the reduction of proinflammatory cytokines may open new perspectives in the treatment of uremia...
  78. pmc Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice
    Suguru Yamamoto
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA
    Nephrol Dial Transplant 26:2491-7. 2011
    ..We, therefore, investigated whether AST-120 affects CKD-induced atherosclerosis...
  79. doi Free heme is a danger signal inducing expression of proinflammatory proteins in cultured cells derived from normal rat hearts
    Kazuhisa Hao
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8120, Japan
    Mol Immunol 48:1191-202. 2011
    ....
  80. doi An ex vivo approach to the differential parenchymal responses induced by cigarette whole smoke and its vapor phase
    James Chi Jen Lin
    Imperial Tobacco Canada Ltd, Montreal, QC, H4C 3P6, Canada
    Toxicology 293:125-31. 2012
    ..The 4% whole smoke deposited about 7.1 μg/cm² of total particulate matter (TPM) to the exposure chamber which may account for observed differential stress responses in the lung slices...
  81. doi Protective effects of sinomenine against doxorubicin-induced nephrosis in rats
    Jie Zhang
    Department of Pediatrics, Jingling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China
    J Asian Nat Prod Res 14:678-87. 2012
    ..SN ameliorates DOX-induced nephrotic syndrome in rats, resulting in a modulation of renal nephrin, podocin expression, and thereby protecting podocytes from injury...
  82. pmc The Notch pathway attenuates interleukin 1β (IL1β)-mediated induction of adenylyl cyclase 8 (AC8) expression during vascular smooth muscle cell (VSMC) trans-differentiation
    Zela Keuylian
    University Paris 06, UR4, Paris, France
    J Biol Chem 287:24978-89. 2012
    ....
  83. pmc Effect of endothelin receptor antagonist bosentan on chronic hypoxia-induced inflammation and chemoafferent neuron adaptation in rat carotid body
    Xuemei Liu
    Department of Physiology, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    High Alt Med Biol 13:209-16. 2012
    ..ET-1 may act in an autocrine/paracrine mechanism via ET-A receptors on chemosensory type I cells and immune cells to promote an inflammatory response...
  84. doi F-actin may play an important role in IL-1β-stimulated hippocampal neurons
    Xueping Zhang
    Department of Psychiatry, Renmin Hospital, Wuhan University, Jiefang Road 238, Wuhan 430060, China
    Behav Brain Res 243:165-70. 2013
    ..The aim of this study was to investigate whether IL-1β treatment affects F-actin in hippocampal neurons...
  85. doi The pro-inflammatory cytokines IL-1β and TNFα are neurotrophic for enteric neurons
    P Y Gougeon
    Gastrointestinal Diseases Research Unit, Department of Medicine, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Neurosci 33:3339-51. 2013
    ..Pro-inflammatory cytokines promote neurite growth through upregulation of GDNF, a novel process that may facilitate re-innervation of smooth muscle cells and a return to homeostasis following initial damage...
  86. doi Effect of interleukin-1β on peripheral blood leukocytes in rats with various behavioral characteristics during acute stress
    E V Koplik
    P K Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia
    Bull Exp Biol Med 156:435-40. 2014
    ....
  87. doi Effects of Wharton's jelly cells of the human umbilical cord on acute spinal cord injury in rats, and expression of interleukin-1β and nerve growth factor in spinal cord tissues
    Cheng Li
    a Department of Orthopedic Surgery, Changhai Hospital, The Second Military Medical University, Shanghai, P R China
    Artif Cells Nanomed Biotechnol 44:1254-8. 2016
    ..05). WJC transplantation changed the microenvironment of the SCI site, inhibited IL-1β expression, increased NGF expression, promoted the recovery of neurological function, and relieved secondary SCI. ..
  88. doi Inflammatory Cytokines Stimulate Bone Morphogenetic Protein-2 Expression and Release from Pancreatic Beta Cells
    Adriana Ibarra Urizar
    1 Section of Cellular and Metabolic Research, Department of Biomedical Sciences, University of Copenhagen, Copenhagen N, Denmark
    J Interferon Cytokine Res 36:20-9. 2016
    ..In conclusion, we suggest that NFκB stimulates BMP-2 mRNA expression in rat and human beta cells upon cytokine exposure. ..
  89. doi The stellate vascular smooth muscle cell phenotype is induced by IL-1β via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation
    Karl Blirando
    Sorbonne Universités, UPMC Univ Paris 06CNRS UMR 8256 B2A, IBPS, F 75005, Paris, France
    Biochim Biophys Acta 1853:3235-47. 2015
    ..Finally, by knocking down the expression of the regulatory subunit PKAR1α, thereby reproducing the effects of IL-1β and PGE₂ on VSMCs, we demonstrated the contribution of PKA activity to the observed behavior of VSMCs...
  90. doi Exercise preconditioning reduces neonatal incision surgery-induced enhanced hyperalgesia via inhibition of P38 mitogen-activated protein kinase and IL-1β, TNF-α release
    Xingrui Gong
    Department of Anesthesiology and Pediatric Clinical Pharmacology Laboratory, Shanghai Children s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Int J Dev Neurosci 52:46-54. 2016
    ..Exercise preconditioning is an effective approach to reducing enhanced adult hyperalgesia primed by neonatal surgery. The mechanism may be explained by exercise-induced inhibition of P-p38 activation and IL-1β, TNF-α release. ..
  91. ncbi Interleukin-1-beta gene, but not the interleukin-1 receptor antagonist gene, is associated with Graves' disease
    Rong Hsing Chen
    Department of Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan
    J Clin Lab Anal 19:133-8. 2005
    ..It is worthwhile to study the cytokine genes further because of the association between cytokines and Graves' disease...
  92. pmc Hyperglycemia in streptozotocin-induced diabetes leads to persistent inflammation and tissue damage following uveitis due to reduced levels of ciliary body heme oxygenase-1
    Settimio Rossi
    Department of Experimental Medicine, Second University of Naples, Naples, Italy
    Mediators Inflamm 2006:60285. 2006
    ..Impairment of the stress-sensitive enzyme HO-1 in STZ-hyperglycemic rats increases and prolongs the inflammatory response to EIU...
  93. ncbi Illuminating the interrelated immune and endocrine adaptations after multiple exposures to short immobilization stress by in vivo blocking of IL-6
    C Smith
    Department of Physiological Sciences, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa
    Am J Physiol Regul Integr Comp Physiol 292:R1439-47. 2007
    ....
  94. ncbi [Association of cytokines genes (ILL, IL1RN, TNF, LTA, IL6, IL8, IL0) polymorphic markers with chronic obstructive pulmonary disease]
    K V Danilko
    Mol Biol (Mosk) 41:26-36. 2007
    ..Polymorphisms in the genes encoding IL1B, IL1RN, TNFA, LTA, IL6, IL8 H IL10 were investigated in COPD patients (N = 319) and healthy individuals (N = 403) ..
  95. ncbi Gene expression profile related to inflammation in rat model of traumatic deep vein thrombosis
    Chun Qiang Zhang
    Department of Orthopaedics, First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan 650032, China
    Chin J Traumatol 10:206-12. 2007
    ..To study the relationship between inflammation and traumatic deep vein thrombosis (TDVT)...
  96. ncbi alpha-melanocyte-stimulating hormone gene transfer attenuates inflammation after bile duct ligation in the rat
    Chien Che Wang
    Department of Surgery, PoJen General Hospital, Taipei, Taiwan
    Dig Dis Sci 53:556-63. 2008
    ..Our findings show that gene transfer of alpha-MSH could attenuate hepatic inflammation after bile duct ligation in the rat...
  97. ncbi Notch3 and IL-1beta exert opposing effects on a vascular smooth muscle cell inflammatory pathway in which NF-kappaB drives crosstalk
    Nathalie Clement
    UMR 7079 de Physiologie et Physiopathologie, Universite Pierre et Marie Curie, CNRS, 7 quai Saint Bernard 75252 Paris, France
    J Cell Sci 120:3352-61. 2007
    ..These results demonstrate that the Notch3 pathway is attenuated through NF-kappaB activation, allowing vascular smooth muscle cells to switch into an inflammatory state...
  98. pmc Interleukin-1beta release in the supraoptic nucleus area during osmotic stimulation requires neural function
    J Y Summy-Long
    Department of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA 17033, USA
    J Neuroendocrinol 20:1224-32. 2008
    ....
  99. doi IL-1 gene polymorphisms and genetic susceptibility of gallbladder cancer in a north Indian population
    Monika Vishnoi
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareilly Road, Lucknow 226014, India
    Cancer Genet Cytogenet 186:63-8. 2008
    ..061; OR = 3.04; 95%CI = 0.95-9.70). Individuals with 1/C and 2/C haplotypes of IL-1RN VNTR and -511IL-1B C --> T polymorphisms were more susceptible to develop GBC with gallstones compared to healthy controls in north India...
  100. doi Reduced collagen biosynthesis is the hallmark of cerebral aneurysm: contribution of interleukin-1beta and nuclear factor-kappaB
    Tomohiro Aoki
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Arterioscler Thromb Vasc Biol 29:1080-6. 2009
    ..We previously reported excessive ECM degradation in CA walls. In the present study, we examined collagen biosynthesis in CA walls and the molecular mechanisms underlying it in CA progression...

Research Grants7

  1. Effects of Acupuncture on Bone Cancer Pain in Mice
    Ruixin Zhang; Fiscal Year: 2004
    ..These studies will set a stage for further studying the mechanisms of EA in the control and management of cancer pain. ..
  2. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2005
    ..abstract_text> ..
  3. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2009
    ..abstract_text> ..
  4. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..
  5. Melanocortins, Energy Balance and Cancer Anorexia
    Brent Wisse; Fiscal Year: 2006
    ..Schwartz and the Harborview Medical Center Energy Metabolism Laboratory, and by joining a large community of productive researchers in the field of energy homeostasis across the University of Washington campus. ..
  6. VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURY
    James Frank; Fiscal Year: 2006
    ..This research and comprehensive career development plan will prepare me to become an independent investigator in the mechanisms of alveolar epithelial injury and ventilator-associated lung injury. ..
  7. MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSIS
    Deborah Carlson; Fiscal Year: 2006
    ..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..