Il10

Summary

Gene Symbol: Il10
Description: interleukin 10
Alias: IL10X, interleukin-10, CSIF, IL-10, cytokine synthesis inhibitory factor
Species: rat

Top Publications

  1. ncbi Role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhage
    Yukihiro Yokoyama
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 35294 0019, USA
    Am J Physiol Gastrointest Liver Physiol 286:G942-6. 2004
  2. ncbi Suppression of experimental crescentic glomerulonephritis by interleukin-10 gene transfer
    Adel G A El-Shemi
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Kidney Int 65:1280-9. 2004
  3. ncbi Balance between plasma levels of tumor necrosis factor-alpha and interleukin-10 in rheumatic mitral stenosis
    Mien Cheng Chen
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Niao Sung Hsiang, Kaohsiung, Taiwan, ROC
    Cardiology 104:171-5. 2005
  4. ncbi Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309, USA
    Pain 126:294-308. 2006
  5. pmc Expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in hepatic stellate cells during rat hepatic fibrosis and its intervention by IL-10
    Wei Da Zheng
    Department of Gastroenterology, Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China
    World J Gastroenterol 11:1753-8. 2005
  6. ncbi Systemic perfluorohexane attenuates lung injury induced by lipopolysaccharide in rats: the role of heme oxygenase-1
    Zhi Jun Ge
    Department of Anesthesiology, Affiliated Yixing People s Hospital, Jiangsu University, Yixing City, Jiangsu Province 214200, China
    Pharmacol Rep 62:170-7. 2010
  7. doi GSK-3 mediates the release of IL-1β, TNF-α and IL-10 from cortical glia
    Holly F Green
    Department of Anatomy and Neuroscience, University College Cork, Ireland
    Neurochem Int 61:666-71. 2012
  8. ncbi Impaired cytokine production by peripheral blood mononuclear cells in type 1 diabetic patients
    N T Foss
    Division of Dermatology, Department of Medicine, Ribeirao Preto Medical School, Sao Paulo University, Av Bandeirantes, 3900 Monte Alegre, 14049 900 Monte Alegre, Brazil
    Diabetes Metab 33:439-43. 2007
  9. doi The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats
    Li Feng Huang
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, People s Republic of China
    Shock 31:322-9. 2009
  10. doi Genetic determined downregulation of both type 1 and type 2 cytokine pathways might be protective against pancreatic cancer
    Letizia Scola
    Cattedra di Patologia Clinica, General Pathology Section, Department of Pathobiology and Biomedical Methodologies, University of Palermo, Corso Tukory, Palermo, Italy
    Ann N Y Acad Sci 1155:284-8. 2009

Research Grants

Detail Information

Publications150 found, 100 shown here

  1. ncbi Role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhage
    Yukihiro Yokoyama
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 35294 0019, USA
    Am J Physiol Gastrointest Liver Physiol 286:G942-6. 2004
    ..These results indicate that IL-10 production by Kupffer cells early after T-H may play a pivotal role in attenuating the proinflammatory cytokine environment, possibly in an autocrine/paracrine manner...
  2. ncbi Suppression of experimental crescentic glomerulonephritis by interleukin-10 gene transfer
    Adel G A El-Shemi
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Kidney Int 65:1280-9. 2004
    ..Investigated were effects of overexpression of interleukin-10 (IL-10) on the outcome and progression of crescentic glomerulonephritis in Wistar-Kyoto (WKY) rats...
  3. ncbi Balance between plasma levels of tumor necrosis factor-alpha and interleukin-10 in rheumatic mitral stenosis
    Mien Cheng Chen
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Niao Sung Hsiang, Kaohsiung, Taiwan, ROC
    Cardiology 104:171-5. 2005
    ....
  4. ncbi Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309, USA
    Pain 126:294-308. 2006
    ..Together, these data suggest that intrathecal IL-10 gene therapy may provide a novel approach for prolonged clinical pain control...
  5. pmc Expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in hepatic stellate cells during rat hepatic fibrosis and its intervention by IL-10
    Wei Da Zheng
    Department of Gastroenterology, Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China
    World J Gastroenterol 11:1753-8. 2005
    ..To investigate the expression of matrix metallopr-oteinase-2 and tissue inhibitor of metalloproteinase-1 in hepatic fibrosis and the antifibrogenic role of exogenous interleukin-10 (IL-10)...
  6. ncbi Systemic perfluorohexane attenuates lung injury induced by lipopolysaccharide in rats: the role of heme oxygenase-1
    Zhi Jun Ge
    Department of Anesthesiology, Affiliated Yixing People s Hospital, Jiangsu University, Yixing City, Jiangsu Province 214200, China
    Pharmacol Rep 62:170-7. 2010
    ..In summary, systemic perfluorohexane alleviates LPS-induced lung injury in rats, and HO-1 may be involved in the mechanism of this reduction...
  7. doi GSK-3 mediates the release of IL-1β, TNF-α and IL-10 from cortical glia
    Holly F Green
    Department of Anatomy and Neuroscience, University College Cork, Ireland
    Neurochem Int 61:666-71. 2012
    ..These results demonstrate a role for GSK-3 as a modulator of inflammatory cytokine levels in the brain, and contribute to a mechanistic insight into neurological disorders in which neuroinflammation is a characteristic feature...
  8. ncbi Impaired cytokine production by peripheral blood mononuclear cells in type 1 diabetic patients
    N T Foss
    Division of Dermatology, Department of Medicine, Ribeirao Preto Medical School, Sao Paulo University, Av Bandeirantes, 3900 Monte Alegre, 14049 900 Monte Alegre, Brazil
    Diabetes Metab 33:439-43. 2007
    ....
  9. doi The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats
    Li Feng Huang
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, People s Republic of China
    Shock 31:322-9. 2009
    ..The excessively released HMGB1 might stimulate CD4+CD25+Treg activity via binding RAGE on the surface of Tregs and trigger a shift of T(H)1 to T(H)2 with suppression of T-lymphocyte immune function after burn injury...
  10. doi Genetic determined downregulation of both type 1 and type 2 cytokine pathways might be protective against pancreatic cancer
    Letizia Scola
    Cattedra di Patologia Clinica, General Pathology Section, Department of Pathobiology and Biomedical Methodologies, University of Palermo, Corso Tukory, Palermo, Italy
    Ann N Y Acad Sci 1155:284-8. 2009
    ..These results strongly suggest that a genetic background associated to a mild downregulation of type 1 and type 2 inflammatory signals might be protective against pancreatic cancer...
  11. ncbi Myocardial expression of TNF-alpha, IL-1beta, IL-6, IL-8, IL-10 and MCP-1 after a single MDMA dose administered in a rat model
    Margherita Neri
    Department of Forensic Pathology, University of Foggia, Ospedale Colonnello D Avanzo, 71100 Foggia, Italy
    Curr Pharm Biotechnol 11:413-20. 2010
    ..The rise of the selective cardioinhibitory cytokines may be interpreted as the adaptive response of jeopardized myocardium to the cardiac dysfunction resulting from MDMA injection...
  12. ncbi IL-1-driven endogenous IL-10 production protects against the systemic and local acute inflammatory response following intestinal reperfusion injury
    Danielle G Souza
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    J Immunol 170:4759-66. 2003
    ..Thus, IL-1 plays a major role in driving endogenous IL-10 production and protects against the TNF-alpha-dependent systemic and local acute inflammatory response following intestinal reperfusion injury...
  13. ncbi The activity of N-acetyl-beta-D-glucosaminidase and tumor necrosis factor-alpha at early stage of diabetic retinopathy development in type 1 diabetes mellitus children
    Małgorzata Myśliwiec
    Institute of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk, ul Debinki 7, 80 952 Gdansk, Poland
    Clin Biochem 39:851-6. 2006
    ..The assessment of the clinical significance of TNF-alpha, IL-10 and NAG with its A and B isoforms concentrations in children with DM type 1 for the detection of early stages of both diabetic retinopathy and nephropathy...
  14. doi Insulin regulates cytokines and intercellular adhesion molecule-1 gene expression through nuclear factor-kappaB activation in LPS-induced acute lung injury in rats
    Joilson O Martins
    Research Division, Heart Institute InCor, LIM 11, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Shock 31:404-9. 2009
    ..In conclusion, data presented suggest that insulin regulates transcription of proinflammatory (IL-1 beta, TNF-alpha) and anti-inflammatory (IL-10) cytokines, and expression of ICAM-1 via the NF-kappaB signaling pathway...
  15. ncbi Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: evidence for decreased platelet production
    J A Sosman
    Section of Hematology Oncology, University of Illinois at Chicago College of Medicine, 60612, USA
    Br J Haematol 111:104-11. 2000
    Recombinant human interleukin 10 (rhuIL-10) inhibits the production of proinflammatory cytokines and has shown promise in the treatment of inflammatory bowel disease...
  16. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
    ..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
  17. ncbi Expression and regulation of interleukin-10 and interleukin-10 receptor in rat astroglial and microglial cells
    Annemarie Ledeboer
    Department of Medical Pharmacology, Research Institute Neurosciences Free University, VUMC, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Eur J Neurosci 16:1175-85. 2002
    ..Together the findings support the concept that IL-10, produced by activated microglial and astroglial cells, modulates glia-mediated inflammatory responses through high-affinity IL-10 receptors via paracrine and autocrine interactions...
  18. pmc Endogenous interleukin-10 is required for the defervescence of fever evoked by local lipopolysaccharide-induced and Staphylococcus aureus-induced inflammation in rats
    T Cartmell
    National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
    J Physiol 549:653-64. 2003
    ..Our data support a crucial regulatory role for endogenous IL-10 in limiting the fever responses during both Gram-negative and Gram-positive infections...
  19. ncbi Interleukin-10 and related cytokines and receptors
    Sidney Pestka
    Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Annu Rev Immunol 22:929-79. 2004
    ..Further investigation of these critical intercellular signaling molecules will provide important information to enable these proteins to be used more extensively in therapy for a variety of diseases...
  20. pmc Effects of platelet-derived growth factor and interleukin-10 on Fas/Fas-ligand and Bcl-2/Bax mRNA expression in rat hepatic stellate cells in vitro
    Xiao Zhong Wang
    Department of Gastroenterology, Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China
    World J Gastroenterol 10:2706-10. 2004
    ..To investigate the effects of platelet-derived growth factor(PDGF) and interleukin-10 (IL-10) on Fas/Fas-ligand and Bcl-2/Bax mRNA expressions in rat hepatic stellate cells...
  21. ncbi Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis
    Cathryn A Broderick
    Division of Molecular Therapy, Institute of Ophthalmology, University College, London, 11 43 Bath Street, London EC1V 9EL, UK
    Mol Ther 12:369-73. 2005
    ....
  22. ncbi Regulation of interleukin IL-4, IL-13, IL-10, and their downstream components in lipopolysaccharide-exposed rat lungs. Comparison of the constitutive expression between rats and humans
    Andreas C Hocke
    Department of Internal Medicine Infectious and Pulmonary Diseases, Charite Universitatsmedizin Berlin, Campus Mitte, Schumannstrasse 20 21, 10117 Berlin, Germany
    Cytokine 33:199-211. 2006
    ..We conclude that non-leukocytic cells in the organism play an important role in the regulation of organ-specific inflammatory reactions, especially in lungs...
  23. pmc Macrophages inhibit neovascularization in a murine model of age-related macular degeneration
    Rajendra S Apte
    Department of Ophthalmology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Med 3:e310. 2006
    ..The current theory is that macrophage infiltration promotes the development of neovascularization in CNV...
  24. pmc Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Brain Behav Immun 21:686-98. 2007
    ..We propose that targeting the production of proinflammatory cytokines by intrathecal IL-10 gene therapy may be a promising therapeutic strategy for the relief of paclitaxel-induced neuropathic pain...
  25. doi Physical exercise improves plasmatic levels of IL-10, left ventricular end-diastolic pressure, and muscle lipid peroxidation in chronic heart failure rats
    R B Nunes
    Physiological Sciences Dept, UFCSPA, Sarmento Leite, 245 308, 90050 170, Porto Alegre, RS, Brazil
    J Appl Physiol (1985) 104:1641-7. 2008
    ..05). These findings demonstrate that regular physical training using a swimming protocol, with duration of 8 wk, improves the cardiac function and the anti-inflammatory response and reduces muscle cellular damage...
  26. pmc Expression of IL-10 and TNF-alpha in rats with cerebral infarction after transplantation with mesenchymal stem cells
    Nan Liu
    Department of Neurology, Union Hospital, Fujian Medical University, Fuzhou 350001, China
    Cell Mol Immunol 6:207-13. 2009
    ..This study strongly suggested transplantation with MSCs could reduce neuronal injury post focal cerebral ischemia in rats partly by regulating the expressions of IL-10 and TNF-alpha in the brain...
  27. pmc Interleukin-10 provides direct trophic support to neurons
    Zhigang Zhou
    Department of Neurology, University of Michigan and Ann Arbor VA Healthcare System, Ann Arbor, Michigan, USA
    J Neurochem 110:1617-27. 2009
    ..These data indicate that in addition to known anti-inflammatory effects through astroglia in other inflammatory cells, IL-10 has direct neuronal effects with important implications for development and neuroprotection...
  28. pmc IL-10 promotes neuronal survival following spinal cord injury
    Zhigang Zhou
    Department of Neurology, University of Michigan and Ann Arbor VA Healthcare System, 5027 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Exp Neurol 220:183-90. 2009
    ....
  29. doi Exercise training changes IL-10/TNF-alpha ratio in the skeletal muscle of post-MI rats
    M L Batista
    Cell and Developmental Biology Department, Institute of Biomedical Sciences I, University of Sao Paulo, Sao Paulo, Brazil
    Cytokine 49:102-8. 2010
    ..6-fold, P<0.001) in post-MI HF rats. As a consequence, the IL-10/TNF-alpha ratio was increased. This "anti-inflammatory effect" was more pronounced in the soleus than in the EDL, suggesting a fiber composition dependent response...
  30. pmc Herpes simplex virus vector-mediated expression of interleukin-10 reduces below-level central neuropathic pain after spinal cord injury
    Darryl Lau
    Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Neurorehabil Neural Repair 26:889-97. 2012
    ..Neuroimmune activation in the spinal dorsal horn plays an important role in the pathogenesis of chronic pain after peripheral nerve injury...
  31. pmc Extracellular signal-regulated kinase 1/2 activation, via downregulation of mitogen-activated protein kinase phosphatase 1, mediates sex differences in desoxycorticosterone acetate-salt hypertension vascular reactivity
    Fernanda R Giachini
    Medical College of Georgia, Department of Physiology, 1120 Fifteenth St, CA 2095, Augusta, GA 30912 3000, USA
    Hypertension 55:172-9. 2010
    ..In addition, mitogen-activated protein kinase phosphatase 1 and interleukin 10 play regulatory roles in this process.
  32. pmc Production of interleukin-10 by human bronchogenic carcinoma
    D R Smith
    Department of Medicine, University of Michigan Medical Center, Ann Arbor 48109 0360
    Am J Pathol 145:18-25. 1994
    ..These findings demonstrate that human bronchogenic carcinomas elaborate functional IL-10, which may significantly impair immune effector cell function and enable the tumor to evade host defenses...
  33. ncbi Serum levels of tetranectin, intercellular adhesion molecule-1 and interleukin-10 in B-chronic lymphocytic leukemia
    E F Kamper
    Department of Experimental Physiology, School of Medicine, National and Kapodistrian University of Athens, Greece
    Clin Biochem 32:639-45. 1999
    ..Our aim was to investigate the potential usefulness of these molecules as prognostic markers in B-CLL...
  34. pmc Identification of Th2-type suppressor T cells among in vivo expanded ocular T cells in mice with experimental autoimmune uveoretinitis
    H Keino
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Clin Exp Immunol 124:1-8. 2001
    ..These findings demonstrate that p518-529 reactive Th2-type T cells expand oligoclonally in the uveitic eyes in the late stage of EAU and may function as Th2-type suppressor T cells for improvement of the disease...
  35. ncbi Polymorphisms of interleukin 4 receptor gene and interleukin 10 gene are not associated with Graves' disease in the UK
    Karen F Tait
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TH, UK
    Autoimmunity 37:189-94. 2004
    ..Cytokines, such as interleukin 4 (IL-4) and interleukin 10 (IL-10), are involved in the immune response and may be implicated in the autoimmune disease process...
  36. ncbi Down-regulation of IFN-gamma-producing CD56+ T cells after combined low-dose cyclosporine/prednisone treatment in patients with Behçet's uveitis
    Jae Kyoun Ahn
    Department of Ophthalmology, Seoul National University College Medicine, Seoul, Korea
    Invest Ophthalmol Vis Sci 46:2458-64. 2005
    ..To investigate the effects of combined low-dose cyclosporine and prednisone (Cs/Pd) treatment on circulating CD56+ T cells in patients with Behçet's uveitis...
  37. ncbi Interleukin-10 gene therapy attenuates pulmonary tissue injury caused by mesenteric ischemia-reperfusion in a mouse model
    Burhan Kabay
    Department of General Surgery, Pamukkale University Faculty of Medicine, Denizli, Turkey
    Tohoku J Exp Med 207:133-42. 2005
    ..Plasmid DNA encoding human IL10 (hIL-10) or empy vector was injected intraperitoneally 24 h before the study...
  38. pmc Interleukin 10 and transforming growth factor beta contribute to the development of experimentally induced allergic conjunctivitis in mice during the effector phase
    A Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Nankoku, Japan
    Br J Ophthalmol 90:1535-41. 2006
    ..To investigate the involvement of interleukin (IL)10 and transforming growth factor (TGF) beta in the development of experimentally induced allergic conjunctivitis in mice...
  39. pmc Role of secreted conjunctival mucosal cytokine and chemokine proteins in different stages of trachomatous disease
    Troy A Skwor
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
    PLoS Negl Trop Dis 2:e264. 2008
    ..Vaccine development requires, in part, knowledge of the mucosal host immune responses in both healthy and trachomatous conjuctivae-an area of research that remains insufficiently studied...
  40. doi Regulatory function of CpG-activated B cells in late-phase experimental allergic conjunctivitis
    Dai Miyazaki
    Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, 36 1 Nishicho Yonago, Tottori, Japan
    Invest Ophthalmol Vis Sci 50:1626-35. 2009
    ..To determine how CpG, an immunostimulatory sequence, affects experimental allergic conjunctivitis and to determine the mechanisms of its action...
  41. pmc The relationship between thyroid function, serum monokine induced by interferon gamma and soluble interleukin-2 receptor in thyroid autoimmune diseases
    J Jiskra
    3rd Clinic of Medicine, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague, Czech Republic
    Clin Exp Immunol 156:211-6. 2009
    ..573, P = 0.00234) and positively with TSH (R = 0.462, P = 0.0179). The results suggest that serum concentrations of sIL-2R and MIG are related to thyroid function rather than to activation of autoimmunity...
  42. doi Attenuation of lipopolysaccharide-induced acute lung injury by treatment with IL-10
    Chieh Liang Wu
    Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Respirology 14:511-21. 2009
    ..The aim of this study was to characterize the changes in neutrophils and cytokines in BAL fluid following acute lung injury (ALI), and to determine the protective effect of post-injury treatment with IL-10...
  43. doi Neutralization of IL-10 exacerbates cycloheximide-induced hepatocellular apoptosis and necrosis
    Kazuyoshi Kumagai
    Medicinal Safety Research Laboratories, Daiichi Sankyo Co, Ltd, Fukuroi, Shizuoka 437 0065, Japan
    Toxicol Pathol 37:536-46. 2009
    ..These results demonstrate that IL-10 plays an important role in counteracting the effect of proinflammatory cytokines, such as a TNF signaling cascade, and in attenuating the CHX-induced liver injury...
  44. doi Cytokine production from sputum cells and blood leukocytes in asthmatics according to disease severity
    M Manise
    Department of Respiratory Medicine, CHU Sart Tilman, University of Liege, GIGA, Research Group i3, Liege, Belgium
    Allergy 65:889-96. 2010
    ..Although mild to moderate asthma is known to be Th2 driven, cytokines produced in refractory asthma might not fit the classical Th2 pattern...
  45. doi Noradrenaline acting at central beta-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: implications for neurodegeneration
    Eoin N McNamee
    Neuroimmunology Research Group, Trinity College Institute of Neuroscience, Department of Physiology and School of Medicine, Trinity College, Dublin 2, Ireland
    Brain Behav Immun 24:660-71. 2010
    ..In all, these data indicate that increasing central noradrenergic tone induces IL-10 production and signaling in the CNS, which may protect against neurodegeneration...
  46. doi IL-10 delivery by AAV5 vector attenuates inflammation in mice with Pseudomonas pneumonia
    S M Buff
    Department of Microbiology and Immunology, Darby Children s Research Institute, Medical University of South Carolina, Charleston, SC, USA
    Gene Ther 17:567-76. 2010
    ..These results suggest that AAV5.Cbeta-mIL10 induces IL-10 levels in the lungs mediating a significant anti-inflammatory response and making AAV-IL-10 gene transfer a potentially useful therapy in the treatment of CF lung disease...
  47. doi Factors associated with inflammatory cytokine patterns in community-acquired pneumonia
    R Martinez
    Servicio de Neumologia, Hospital Universitario La Fe, Valencia, Spain
    Eur Respir J 37:393-9. 2011
    ....
  48. doi Genetic susceptibility to Graves' ophthalmopathy: The role of polymorphisms in anti-inflammatory cytokine genes
    Omid Khalilzadeh
    Endocrinology and Metabolism Research Center EMRC, Vali Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Ophthalmic Genet 31:215-20. 2010
    ..In this study, we investigated the association between 8 polymorphisms within the mentioned cytokines and GO...
  49. doi Advantages of promoting interleukin-10 by silence of histone deacetylase 11 in inducing tolerance in orthotopic liver transplantation in rats
    X Lai
    Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
    Transplant Proc 43:2728-32. 2011
    ..The aims of this study were to study the role of histone deacetylase 11 (HDAC11) in tolerance induction in orthotopic liver transplantation (OLT) in rats and to assess the advantages of gene therapy over the immunosuppressant FK506...
  50. doi Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat
    Gerard F Curley
    Anaesthesia, School of Medicine, Clinical Sciences Institute, National University of Ireland, Galway, Ireland
    Thorax 67:496-501. 2012
    ..A study was undertaken to determine the potential for MSCs to enhance repair after ventilator-induced lung injury (VILI) and elucidate the mechanisms underlying these effects...
  51. doi Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice
    M Uchiyama
    Department of Cardiovascular Surgery, Juntendo University Hospital, Tokyo, Japan
    Transplant Proc 44:1076-9. 2012
    ..In conclusion, exposure to some types of music may induce prolonged survival of fully allogeneic cardiac allografts and generate CD4(+)CD25(+)Foxp3(+) regulatory cells...
  52. pmc Adjunctive daptomycin attenuates brain damage and hearing loss more efficiently than rifampin in infant rat pneumococcal meningitis
    Denis Grandgirard
    Neuroinfection Laboratory, Institute for Infectious Diseases, University of Bern, Switzerland
    Antimicrob Agents Chemother 56:4289-95. 2012
    ..02 for IL-6 at 6 h), it had no significant effect on apoptosis and hearing capacity. Adjuvant daptomycin could therefore offer added benefits for the treatment of pediatric pneumococcal meningitis...
  53. pmc Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice
    Janhavi Athale
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 53:1584-94. 2012
    ..Absence of Nrf2 suppresses the alveolar transcriptional network for mitochondrial biogenesis and anti-inflammation, which worsens ALI. The findings link redox activation of mitochondrial biogenesis to ALI resolution...
  54. pmc Peripheral blood and tissue T regulatory cells in chronic rhinosinusitis
    Shilpy Sharma
    Section of Otolaryngology Head and Neck Surgery, Department of Surgery, The University of Chicago, Chicago, Illinois, USA
    Am J Rhinol Allergy 26:371-9. 2012
    ..Increased inflammatory cell infiltration and decreased numbers and/or impaired function of T regulatory cells (Tregs) have been reported. This study aimed to determine the role of Tregs in CRS in peripheral blood (PB) and sinus tissue...
  55. doi Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model
    A Kleinjan
    Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
    Allergy 68:204-12. 2013
    ..FTY720 exploits S1P biology by acting as a S1P1 and S1P 3 agonist and by inhibiting S1P breakdown by SL...
  56. doi Cytokine profiles in acute myeloid leukemia patients at diagnosis: survival is inversely correlated with IL-6 and directly correlated with IL-10 levels
    Beatriz Sanchez-Correa
    Immunology Unit, Department of Physiology, University of Extremadura, 10003 Caceres, Spain
    Cytokine 61:885-91. 2013
    ..Several evidences support the existence of cytokine deregulation in acute myeloid leukemia (AML) patients that may be associated with pathogenesis, disease progression and patient survival...
  57. doi Dietary GD3 ganglioside reduces the incidence and severity of necrotizing enterocolitis by sustaining regulatory immune responses
    Jiliu Xu
    Departments of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition Department of Pathology, SUNY Downstate Medical Center, Brooklyn, NY
    J Pediatr Gastroenterol Nutr 57:550-6. 2013
    ....
  58. doi Pro-inflammatory cytokines in glaucomatous aqueous and encysted Molteno implant blebs and their relationship to pressure
    Jeffrey Freedman
    Department of Ophthalmology, State University of New York, Downstate Medical Center, Brooklyn, New York 11201, USA
    Invest Ophthalmol Vis Sci 54:4851-5. 2013
    ..To ascertain the presence of additional pro-inflammatory cytokines in glaucomatous aqueous, and their relationship with IOP...
  59. pmc Erosive arthritis and hepatic granuloma formation induced by peptidoglycan polysaccharide in rats is aggravated by prasugrel treatment
    ANALIA E GARCIA
    Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Temple University Hospital, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e69093. 2013
    ....
  60. doi Aging affects AO rat splenic conventional dendritic cell subset composition, cytokine synthesis and T-helper polarizing capacity
    Zorica Stojić-Vukanić
    Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Serbia
    Biogerontology 14:443-59. 2013
    ..Moreover, in MLR, OX62+ DCs from aged rats exhibited enhanced Th1/Th17 driving force and diminished allostimulatory capacity compared with those from young rats...
  61. doi Mesenchymal stromal cells infusions improve refractory chronic graft versus host disease through an increase of CD5+ regulatory B cells producing interleukin 10
    Y Peng
    Center for Stem Cell Biology and Tissue Engineering, The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou, China
    Leukemia 29:636-46. 2015
    ..Thus, CD5+ Breg cells may have an important role in the process of MSC-induced amelioration of refractory cGVHD and may provide new clues to reveal novel mechanisms of action for MSCs. ..
  62. pmc Peritoneal exudate cells from long-lived rats exhibit increased IL-10/IL-1β expression ratio and preserved NO/urea ratio following LPS-stimulation in vitro
    Mirjana Dimitrijević
    Institute of Virology, Vaccines and Sera, Torlak, Immunology Research Center Branislav Jankovic, Vojvode Stepe 458, 11152, Belgrade, Serbia
    Age (Dordr) 36:9696. 2014
    ..The study suggests that macrophages from long-lived rats, differently from those of old ones, have substantial ability to limit proinflammatory mediator production, which may contribute to their longevity...
  63. pmc Tumour necrosis factor, interleukin-6 and interleukin-10 are possibly involved in Plasmodium vivax-associated thrombocytopaenia in southern Pakistani population
    Afsheen Raza
    Department of Pathology and Microbiology, Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    Malar J 13:323. 2014
    ..vivax-induced thrombocytopaenia. However, study on correlation of cytokines and thrombocytopaenia in P. vivax, particularly in patients with severe signs and symptoms has not been reported from Pakistan...
  64. pmc Mesenchymal stem cells suppress neuronal apoptosis and decrease IL-10 release via the TLR2/NFκB pathway in rats with hypoxic-ischemic brain damage
    Yan Gu
    Children Nutrition Research Centre, Children s Hospital of Chongqing Medical University, Chongqing, 400014, China
    Mol Brain 8:65. 2015
    ..This study aimed to elucidate the mechanisms by which MSCs mediate immunomodulation via the key effectors Toll-like receptor 2 (TLR2) and interleukin-10 (IL-10)...
  65. ncbi Involvement of CD40-CD40L signaling in postischemic lung injury
    Timothy M Moore
    Department of Physiology, University of Alabama College of Medicine, Mobile, Alabama 36688 0002, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1255-62. 2002
    ..Thus acute lymphocyte involvement in lung I/R injury involves CD40-CD40L signaling mechanisms, and these events may be influenced by local IL-10 generation...
  66. doi Interleukin-10 activates Toll-like receptor 4 and requires MyD88 for cardiomyocyte survival
    Ashim K Bagchi
    Institute of Cardiovascular Sciences, Department of Physiology, St Boniface Research Centre, Faculty of Medicine, University of Manitoba, 351 Tache Avenue, Winnipeg, MB, Canada R2H 2A6
    Cytokine 61:304-14. 2013
    ..These data in cardiomyocytes suggest that IL-10 induced anti-apoptotic signaling involves upregulation of TLR4 through MyD88 activation...
  67. ncbi Modulation of IL-10/IL-10R expression by mafosfamide, a derivative of 4-hydroxycyclophosphamide, in a rat B-cell lymphoma
    María J Rico
    Instituto de Genética Experimental, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Santa Fe 3100, 2000 Rosario, Argentina
    Biocell 36:91-5. 2012
    ..These results may have a considerable impact on the design of new therapies for metastatic lymphomas...
  68. doi Lipopolysaccharide-stimulated interleukin-10 release from neonatal spinal cord microglia is potentiated by glutamate
    E L Werry
    The University of Sydney, NSW, Australia
    Neuroscience 175:93-103. 2011
    ..These results show that glutamate substantially increases the release of an anti-inflammatory cytokine from neonatal spinal cord microglia activated by a high concentration of LPS...
  69. ncbi Synthesis and characterization of rat interleukin-10 (IL-10) cDNA clones from the RNA of cultured OX8- OX22- thoracic duct T cells
    R E Goodman
    James A Baker Institute, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853
    Biochem Biophys Res Commun 189:1-7. 1992
    ..The sequence of the coding region of the amplified, cloned rat IL-10 cDNA is 90% identical to the mouse and 82% identical to the human IL-10 cDNA coding regions...
  70. pmc Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes
    A C Fluckiger
    Laboratory for Immunological Research, Schering Plough, Dardilly, France
    J Exp Med 178:1473-81. 1993
    b>Interleukin 10 (IL-10) has recently been shown to induce normal human B lymphocytes to proliferate and differentiate into immunoglobulin (Ig)-secreting cells...
  71. ncbi Human interleukin-10 can directly inhibit T-cell growth
    K Taga
    Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892
    Blood 81:2964-71. 1993
    ..Secretion of IL-2 under these conditions was inhibited by IL-10 (51.5% inhibition). Thus, IL-10 can directly inhibit growth and IL-2 production in T cells triggered by immobilized OKT3 MoAb in the absence of monocytes...
  72. ncbi IL-4 and IL-10 inhibition of IFN-gamma- and TNF-alpha-dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merozoites
    W L Goff
    Animal Disease Research Unit, USDA ARS, Washington State University, 3003 ADBF, P O Box 646630, Pullman, WA 99164 6630, USA
    Vet Immunol Immunopathol 84:237-51. 2002
    ..However, while merozoites plus IFN-gamma induced TNF-alpha mRNA expression in MDM, NO was not produced. Both IL-4 and IL-10 inhibited expression of iNOS and production of NO in merozoite-stimulated monocytes...
  73. ncbi Novel genetic association of Wegener's granulomatosis with the interleukin 10 gene
    Yihua Zhou
    Immunological Research Unit, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    J Rheumatol 29:317-20. 2002
    ..We investigated the polymorphisms in the genes of 2 cytokines, interleukin 4 (IL-4) and IL-10, which are essential for the polarization of T cells towards Th2 development and for the Ig production by B cells...
  74. ncbi Inhibition of microglial CD40 expression by pituitary adenylate cyclase-activating polypeptide is mediated by interleukin-10
    Woong Ki Kim
    Department of Biological Sciences, Rutgers University, 101 Warren Street, Newark, NJ 07102, USA
    J Neuroimmunol 126:16-24. 2002
    ..These data indicate that PACAP, through an increase in IL-10 protein, can down-regulate important costimulatory molecule expression on microglia, thereby possibly affecting CNS immunity...
  75. ncbi Endogenous regulation of the acute inflammatory response
    Peter A Ward
    Department of Pathology, University of Michigan, Ann Arbor 48109, USA
    Mol Cell Biochem 234:225-8. 2002
    ..These data indicate that endogenous IL-10, IL-13 and SLPI are important regulators of the inflammatory response by reducing gene activation with resultant generation of peptide mediators/cytokines and chemokines...
  76. ncbi Kupffer cells modulate splenic interleukin-10 production in endotoxin-induced liver injury after partial hepatectomy
    Kiyotaka Kurachi
    Second Department of Surgery, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    J Hepatol 38:193-9. 2003
    ..This study was conducted to investigate the implication of Kupffer cells and the spleen in interleukin (IL)-10 production in endotoxin-induced liver injury after hepatectomy...
  77. ncbi Regulatory role of IL-10 in experimental obliterative bronchiolitis in rats
    Babu Naidu
    Department of Cardiothoracic Surgery, University of Washington Medical School, Seattle, Washington 98115, USA
    Exp Mol Pathol 73:164-70. 2002
    ..These findings suggest that endogenous IL-10 plays a regulatory role in the development of experimental OB...
  78. ncbi Production of the novel mesangial autocrine growth factors GDNF and IL-10 is regulated by the immunomodulator AS101
    Yona Kalechman
    C A I R Institute, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    J Am Soc Nephrol 14:620-30. 2003
    ..In vivo animal studies using AS101, currently undergoing phase II clinical trials on cancer patients, are warranted to determine its potential in the management of glomerular diseases associated with mesangial cell proliferation...
  79. pmc Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice
    Giuseppina Caligiuri
    INSERM U460, Paris, France
    Mol Med 9:10-7. 2003
    ..The early phase of lesion development was increased, and the proteolytic and procoagulant activity was elevated in advanced lesions. These data show that IL-10 may reduce atherogenesis and improve the stability of plaques...
  80. ncbi Interleukin-10 gene -627 allele variants, not interleukin-I beta gene and receptor antagonist gene polymorphisms, are associated with atopic bronchial asthma
    Liang Wen Hang
    Department of Chest, China Medical College Hospital, Taichung, Taiwan
    J Clin Lab Anal 17:168-73. 2003
    ..The results revealed no significant differences between normal individuals and asthma patients (P=0.454, Fisher's exact test). The IL-10 gene -627 "A" allele is an associated risk factor of developing atopic asthma...
  81. ncbi Promoter haplotypes of interleukin-10 gene and sporadic Alzheimer's disease
    Catia Scassellati
    Genetics Unit, I R C C S Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurosci Lett 356:119-22. 2004
    ..Our results provide new insights on a possible involvement of the IL-10 gene in susceptibility to sporadic AD even though further functional and genetic investigations are necessary to clarify its role in AD...
  82. pmc Down-modulation of lung immune responses by interleukin-10 and transforming growth factor beta (TGF-beta) and analysis of TGF-beta receptors I and II in active tuberculosis
    M Glória Bonecini-Almeida
    Instituto de Pesquisas, Clinica Evandro Chagas, Serviço de Immulogia, FIOCRUZ, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Infect Immun 72:2628-34. 2004
    ..Delineating the underlying mechanisms of M. tuberculosis-triggered expression of these immune elements may provide a molecular-level understanding of TB immunopathogenesis...
  83. ncbi Kupffer cell cytokines interleukin-1beta and interleukin-10 combine to inhibit phosphoenolpyruvate carboxykinase and gluconeogenesis in cultured hepatocytes
    Stephanie T Yerkovich
    Biochemistry and Molecular Biology, University of Western Australia, Nedlands, 35 Stirling Highway, Crawley 6009, WA, Australia
    Int J Biochem Cell Biol 36:1462-72. 2004
    ....
  84. pmc The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10
    Maria K Dahle
    Institute for Surgical Research, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Infect Immun 72:5704-11. 2004
    ....
  85. ncbi Carcinoembryonic antigen promotes tumor cell survival in liver through an IL-10-dependent pathway
    J Milburn Jessup
    Department of Oncology, Georgetown University Medical Center, Washington, DC, USA
    Clin Exp Metastasis 21:709-17. 2004
    ..IL-10 but not IL-6 enhanced CRC survival in nude mouse liver in vivo. Thus, CEA enhanced metastasis by inducing IL-10 to inhibit iNOS upregulation in host liver...
  86. ncbi Lack of association of genetic polymorphisms in the interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4, and interleukin-10 genes with risk of rheumatic heart disease in Taiwan Chinese
    Hsiang Tai Chou
    Division of Cardiology, Department of Medicine, China Medical University Hospital, Taichung, Taiwan
    Int Heart J 46:397-406. 2005
    ..These findings suggest that the IL-1beta, IL-1Ra, IL-4, or IL-10 gene polymorphisms are not suitable genetic markers for RHD in Taiwan Chinese...
  87. ncbi The IL-6 G-174C polymorphism may be associated with ischaemic stroke in patients without a history of hypertension
    J Balding
    Thrombosis and Haemostasis Laboratory, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    Ir J Med Sci 173:200-3. 2004
    ..Recent data suggest that inflammatory reactions are involved in the pathogenesis of cerebral ischaemia...
  88. ncbi Effect of interleukin-10 on gene expression of osteoclastogenic regulatory molecules in the rat dental follicle
    Dawen Liu
    Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, 70803, USA
    Eur J Oral Sci 114:42-9. 2006
    ..In these knockdowns, RANKL expression was increased and OPG expression was decreased. All of these results suggest that IL-10 inhibits bone resorption by up-regulating OPG expression while down-regulating expression of RANKL and CSF-1...
  89. ncbi Interleukin-10 promoter polymorphism and venous thrombosis: a case-control study
    Eva Cochery-Nouvellon
    Laboratoire Central d Hématologie, CHU Robert Debre, Universite de Reims Champagne Ardenne, France
    Thromb Haemost 96:24-8. 2006
    ..33, p = 0.003 and OR = 2.83, p = 0.03, respectively). Furthermore, IL-10 G10 allele is more frequent in recurrent disease...
  90. ncbi Role of microglia in inflammation-mediated degeneration of dopaminergic neurons: neuroprotective effect of interleukin 10
    L Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Neural Transm Suppl . 2006
    ..IL-10 significantly inhibited the microglial production of tumor necrosis factor alpha (TNF-alpha), nitric oxide, ROS and superoxide free radicals after LPS stimulation...
  91. ncbi Antigen-specific tolerance induced by IL-10 gene modified immature dendritic cells in experimental autoimmune myocarditis in rats
    Wei Min Li
    Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, China
    Chin Med J (Engl) 119:1646-52. 2006
    ..This study was designed to test the hypothesis that IL-10 gene modified bone marrow-derived immature dendritic cells (iDCs) ameliorate EAM and to explore the underlying mechanisms...
  92. pmc IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency
    Dawn L DeMeo
    Brigham and Women s Hospital, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 38:114-20. 2008
    ..performed family-based association analyses for 10 genes previously associated with asthma and/or COPD, including IL10, TNF, GSTP1, NOS1, NOS3, SERPINA3, SERPINE2, SFTPB, TGFB1, and EPHX1...
  93. pmc Cross talk between P2 purinergic receptors modulates extracellular ATP-mediated interleukin-10 production in rat microglial cells
    Dong Reoyl Seo
    Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 443 721, Korea
    Exp Mol Med 40:19-26. 2008
    ....
  94. doi Reduced cytokine production by glycogen-elicited peritoneal cells from diabetic rats
    Tatiana Carolina Alba-Loureiro
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Shock 30:308-10. 2008
    ..These changes were abolished by insulin treatment of diabetic rats. The alterations observed might be involved in the impaired inflammatory response and high occurrence of apoptosis observed in neutrophils under diabetic states...
  95. pmc Dynamic changes of IL-2/IL-10, sFas and expression of Fas in intestinal mucosa in rats with acute necrotizing pancreatitis
    Sheng Chun Dang
    Department of General Surgery, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China
    World J Gastroenterol 14:2246-50. 2008
    ..To investigate dynamic changes of serum IL-2, IL-10, IL-2/IL-10 and sFas in rats with acute necrotizing pancreatitis. To explore the expression of Fas in intestinal mucosa of rats with acute necrotizing pancreatitis (ANP)...
  96. doi Poly (lactide-co-glycolide)-polymethacrylate nanoparticles for intramuscular delivery of plasmid encoding interleukin-10 to prevent autoimmune diabetes in mice
    Ashwin Basarkar
    Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, North Dakota 58105, USA
    Pharm Res 26:72-81. 2009
    ..Determine the efficiency of cationic nanoparticles prepared by blending poly (lactide-co-glycolide; PLGA) and methacrylate copolymer (Eudragit(R) E100) to deliver a therapeutic gene encoding mouse interleukin-10, in vitro and in vivo...
  97. doi Tyrosine phosphorylation of vitreous inflammatory and angiogenic peptides and proteins in diabetic retinopathy
    Jordi L Reverter
    Endocrinology and Nutrition Department, Germans Trias i Pujol University Hospital, Universitat Autonoma de Barcelona, Badalona, Spain
    Invest Ophthalmol Vis Sci 50:1378-82. 2009
    ..To evaluate the degree of phosphorylation of vitreous proteins in patients with type 2 diabetes mellitus and diabetic retinopathy compared with a group of control subjects without diabetes and of similar age and sex...
  98. ncbi Is IL-10-819C/T gene polymorphism modulating the risk of gallbladder disease in north Indian population?
    Monika Vishnoi
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
    J Gastrointest Cancer 38:46-51. 2007
    ..Anti-inflammatory cytokine interleukin-10 (IL-10) gene polymorphisms have been associated with susceptibility to various inflammatory diseases and cancers...
  99. ncbi [Effect of danpu capsule on inflammatory factors in rat model of autoimmune prostatitis]
    Min Li
    Guang anmen Hospital, China Academy of Chinese Medical Sciences, Beijing
    Zhongguo Zhong Xi Yi Jie He Za Zhi 28:1018-21. 2008
    ..To explore the acting mechanism of Danpu Capsule (DPC) in treating chronic prostatitis by observing its effect on inflammatory factors in autoimmune prostatitis rat model...
  100. doi Association of inflammatory and anti-inflammatory cytokines with insulin resistance in chronic hepatitis C
    Chao Hung Hung
    Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Liver Int 29:1086-93. 2009
    ..We investigated the association of inflammatory [tumour necrosis factor (TNF)-alpha, interleukin (IL)-6] and anti-inflammatory cytokines (adiponectin and IL-10) with IR in chronic HCV infection...

Research Grants2

  1. Role of Virus and Genetic Susceptibility in Otitis Media
    Cuneyt Alper; Fiscal Year: 2006
    ..These results will be used in the design of future studies that prevent OM by moderating vURI pathogenesis. [unreadable] [unreadable]..
  2. Asthma Candidate Genes in Alpha 1-Antitrypsin Deficiency
    Dawn DeMeo; Fiscal Year: 2007
    ..The identification of modifying factors of COPD in AAT deficiency may have significant public health relevance to COPD patients without AAT deficiency. ..