Igf2

Summary

Gene Symbol: Igf2
Description: insulin-like growth factor 2
Alias: IGFII, RNIGF2, insulin-like growth factor II, IGF-II, Insulin-like growth factor II (somatomedin A), MSA, insulin-like growth factor II (IGF-II), insulin-like growth factor II isoform 2 variant 4 preprotein, multiplication-stimulating activity, multiplication-stimulating polypeptide
Species: rat

Top Publications

  1. pmc Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways by modulating IGF-2
    Ramaswamy Suvasini
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560 012, India
    J Biol Chem 286:25882-90. 2011
  2. pmc A critical role for IGF-II in memory consolidation and enhancement
    Dillon Y Chen
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 469:491-7. 2011
  3. doi Insulin resistance in experimental alcohol-induced liver disease
    Suzanne M de la Monte
    Departments of Medicine, Liver Research Center, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Gastroenterol Hepatol 23:e477-86. 2008
  4. pmc Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer
    Lopamudra Das Roy
    University of North Carolina at Charlotte, Dept, of Biology, 9201 University City Blvd, NC 29223, USA
    BMC Cancer 11:365. 2011
  5. ncbi In utero radiation-induced changes in growth factor levels in the developing rat brain
    A Benekou
    Laboratory of Biology Biochemistry, Faculty of Nursing, University of Athens, Greece
    Int J Radiat Biol 77:83-93. 2001
  6. ncbi Changes in systemic levels of insulin-like growth factors and their binding proteins in patients with rheumatoid arthritis
    J Neidel
    Klinik für Orthopädie, Charite University Hospital, Schumannstrasse 20, D 10117 Berlin, Germany
    Clin Exp Rheumatol 19:81-4. 2001
  7. ncbi Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease
    Nataniel Lester-Coll
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Alzheimers Dis 9:13-33. 2006
  8. ncbi IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor
    L E Diaz
    Hormone Laboratory, Department of Chemistry, Universidad Nacional de Colombia, Bogota, Colombia
    Mol Hum Reprod 13:567-76. 2007
  9. doi Immunolocalization of insulin-like growth factors and their receptors in the diabetic mouse oviduct and uterine tissues during the preimplantation period
    Rahimah Zakaria
    School of Medical Sciences, Universiti Sains Malaysia, 16150 Kota Bharu, Kelantan, Malaysia
    Acta Histochem 111:52-60. 2009
  10. ncbi Tissue-specific regulation of insulin-like growth factors and insulin-like growth factor binding proteins in male diabetic rats in vivo and in vitro
    Ho Jae Han
    Bio therapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju, Korea
    Clin Exp Pharmacol Physiol 33:1172-9. 2006

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Detail Information

Publications91

  1. pmc Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways by modulating IGF-2
    Ramaswamy Suvasini
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560 012, India
    J Biol Chem 286:25882-90. 2011
    ..Thus, we have identified IMP3 as a GBM-specific proproliferative and proinvasive marker acting through IGF-2 resulting in the activation of oncogenic PI3K and MAPK pathways...
  2. pmc A critical role for IGF-II in memory consolidation and enhancement
    Dillon Y Chen
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 469:491-7. 2011
    We report that, in the rat, administering insulin-like growth factor II (IGF-II, also known as IGF2) significantly enhances memory retention and prevents forgetting...
  3. doi Insulin resistance in experimental alcohol-induced liver disease
    Suzanne M de la Monte
    Departments of Medicine, Liver Research Center, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Gastroenterol Hepatol 23:e477-86. 2008
    ..This study characterizes the mechanisms and consequences of ethanol-impaired insulin signaling in relation to oxidative injury and altered gene expression...
  4. pmc Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer
    Lopamudra Das Roy
    University of North Carolina at Charlotte, Dept, of Biology, 9201 University City Blvd, NC 29223, USA
    BMC Cancer 11:365. 2011
    ..Despite this knowledge being available, there has been minimal research linking breast cancer, arthritis, and metastasis associated with breast cancer. Notably both diseases are extremely prevalent in older post-menopausal women...
  5. ncbi In utero radiation-induced changes in growth factor levels in the developing rat brain
    A Benekou
    Laboratory of Biology Biochemistry, Faculty of Nursing, University of Athens, Greece
    Int J Radiat Biol 77:83-93. 2001
    ..To investigate the role of growth factors in the compensatory response to radiation injury during development of the brain. Levels of gene expression in the embryonic rat brain were assessed for IGF-I, IGF-II, BDNF and NT-3...
  6. ncbi Changes in systemic levels of insulin-like growth factors and their binding proteins in patients with rheumatoid arthritis
    J Neidel
    Klinik für Orthopädie, Charite University Hospital, Schumannstrasse 20, D 10117 Berlin, Germany
    Clin Exp Rheumatol 19:81-4. 2001
    ..To determine whether circulating levels of insulin-like growth factors and their binding proteins are altered in patients with adult onset rheumatoid arthritis...
  7. ncbi Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease
    Nataniel Lester-Coll
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Alzheimers Dis 9:13-33. 2006
    ..e. Type 3 diabetes...
  8. ncbi IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor
    L E Diaz
    Hormone Laboratory, Department of Chemistry, Universidad Nacional de Colombia, Bogota, Colombia
    Mol Hum Reprod 13:567-76. 2007
    ..The actions of IGF-II but not those of IGF-I were sensitive to inhibition by the insulin receptor inhibitor HNMPA(AM)3. Our results demonstrate that the insulin receptor regulates choriocarcinoma cell invasion...
  9. doi Immunolocalization of insulin-like growth factors and their receptors in the diabetic mouse oviduct and uterine tissues during the preimplantation period
    Rahimah Zakaria
    School of Medical Sciences, Universiti Sains Malaysia, 16150 Kota Bharu, Kelantan, Malaysia
    Acta Histochem 111:52-60. 2009
    ..In conclusion, the oviductal immunolabelling for IGFs and their receptors was significantly altered by maternal diabetes, which may be of importance in the pathogenesis of preimplantation diabetic embryopathy...
  10. ncbi Tissue-specific regulation of insulin-like growth factors and insulin-like growth factor binding proteins in male diabetic rats in vivo and in vitro
    Ho Jae Han
    Bio therapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju, Korea
    Clin Exp Pharmacol Physiol 33:1172-9. 2006
    ..6. In conclusion, diabetes tissue-specifically alters the IGF system in the liver, heart and kidney in rats; this effect can be recovered by insulin treatment...
  11. pmc Induction of insulin-like growth factor 2 expression in a mesenchymal cell line co-cultured with an ameloblast cell line
    Asako Matsumoto
    Cell Materials Interaction Group, Biomaterials Unit, National Institute for Materials Science, 1 1 Namiki, Tsukuba, Ibaraki, 305 0044, Japan
    In Vitro Cell Dev Biol Anim 47:675-80. 2011
    ..In the present study, we used the SW system to analyze the expression of IGFs and IGFRs. We demonstrate that IGF2 expression in mesenchymal cells was increased by SW...
  12. doi Effects of paternal folate deficiency on the expression of insulin-like growth factor-2 and global DNA methylation in the fetal brain
    Hye Won Kim
    Department of Nutritional Science and Food Management, Ewha Womans University, Seodaemun gu, Seoul, Republic of Korea
    Mol Nutr Food Res 57:671-6. 2013
    ....
  13. doi Acetyl-L-carnitine rescues scopolamine-induced memory deficits by restoring insulin-like growth factor II via decreasing p53 oxidation
    Xiang Wang
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Neuropharmacology 76:80-7. 2014
    ..This article is part of the Special Issue entitled 'The Synaptic Basis of Neurodegenerative Disorders'...
  14. pmc Changes in cerebrospinal fluid and blood plasma levels of IGF-II and its binding proteins in Alzheimer's disease: an observational study
    Joakim Hertze
    Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmo, Sweden
    BMC Neurol 14:64. 2014
    ..In this study we explored changes in the IGF-related system in patients with Alzheimer's disease (AD), including changes in IGF-II levels...
  15. pmc Intergenerational and parent of origin effects of maternal calorie restriction on Igf2 expression in the adult rat hippocampus
    Kathryn M Harper
    The Asher Center, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States
    Psychoneuroendocrinology 45:187-91. 2014
    Insulin-like growth factor 2 (Igf2) regulates development, memory and adult neurogenesis in the hippocampus...
  16. doi Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease
    Ignacio Pedrós
    Unitats de Bioquímica i Farmacologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Tarragona, Spain Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Spain Laboratorio de Regeneración y Desarrollo Neural, Instituto de Neurobiologia, Departamento de Biologia Celular y Molecular, CUCBA, Mexico
    Biochim Biophys Acta 1842:1556-66. 2014
    ..insulin receptor (Insr), Irs1 and Irs2, as well as genes involved in insulin growth factor pathways, such as Igf1, Igf2, Igfr and Igfbp2...
  17. doi Diabetes-associated changes in the fetal insulin/insulin-like growth factor system are organ specific in rats
    Veronica White
    Laboratory of Reproduction and Metabolism, Center for Pharmacological and Botanical Studies, CEFYBO CONICET, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Pediatr Res 77:48-55. 2015
    ..This study tested the hypothesis that maternal diabetes alters the fetal insulin/IGF system in a tissue-specific manner...
  18. pmc Insulin Like Growth Factor 2 Expression in the Rat Brain Both in Basal Condition and following Learning Predominantly Derives from the Maternal Allele
    Xiaojing Ye
    Center for Neural Science, New York University, New York, NY, 10003, United States of America
    PLoS ONE 10:e0141078. 2015
    Insulin like growth factor 2 (Igf2) is known as a maternally imprinted gene involved in growth and development...
  19. ncbi Isolation of a biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors
    J F Wang
    Molecular, Cellular and Nutritional Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, MD 20892
    Biochem Biophys Res Commun 157:718-26. 1988
    ..It corresponds to the carboxy terminus of the native binding protein (residues 148-270), and is thought to arise by proteolysis. We infer that this region of the native binding protein contains, at least in part, the IGF binding domain...
  20. pmc Impaired insulin/IGF signaling in experimental alcohol-related myopathy
    Van Anh Nguyen
    Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA
    Nutrients 4:1058-75. 2012
    ..Moreover, the increased oxidative stress, which could be mediated by mitochondrial dysfunction, may have led to inhibition of acetylcholinesterase, which itself is sufficient to cause myofiber atrophy and degeneration...
  21. pmc Experimental alcohol-related peripheral neuropathy: role of insulin/IGF resistance
    Van Anh Nguyen
    Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA
    Nutrients 4:1042-57. 2012
    ..Therefore, ALPN is likely mediated by molecular and signal transduction abnormalities similar to those identified in alcoholic liver and brain degeneration...
  22. pmc Effects of oxidative stress on intestinal type I insulin-like growth factor receptor expression
    N Baregamian
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 37232, USA
    Eur J Pediatr Surg 22:97-104. 2012
    ..However, the effects of oxidative stress on IGF receptor type I (IGF-IR) activation and expression in the neonatal intestine during NEC are unknown...
  23. doi Potential role of estrogen in regulation of the insulin-like growth factor2-H19 locus in the rat testis
    Shilpa Pathak
    Division of Neuroendocrinology, National Institute for Research in Reproductive Health, Indian Council of Medical Research, JM Road, Parel, Mumbai, Maharashtra 400 012, India
    Mol Cell Endocrinol 314:110-7. 2010
    ..has been shown to reduce DNA methylation at Insulin-like growth factor 2/H19 differentially methylated region (Igf2/H19 DMR) in the spermatozoa of the Holtzman rats...
  24. doi Comparative effects of probiotics, prebiotics, and synbiotics on growth factors in the large bowel in a rat model of formula-induced bowel inflammation
    Lawrence Fordjour
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
    J Pediatr Gastroenterol Nutr 51:507-13. 2010
    ..We tested the hypothesis that probiotics, prebiotics, or synbiotics supplementation preserves intestinal insulin-like growth factors (IGFs) and epidermal growth factors (EGFs) in formula-fed neonatal rats...
  25. doi Maternal undernutrition increases pancreatic IGF-2 and partially suppresses the physiological wave of {beta}-cell apoptosis during the neonatal period
    Laura de Miguel-Santos
    Departamento de Bioquimica y Biologia Molecular II, Universidad Complutense de Madrid, Spain
    J Mol Endocrinol 44:25-36. 2010
    ..In addition, decreased pancreatic levels of IGFBP-1/-2/-3 in undernourished neonates could enhance IGF availability for interacting with IGF-1R/IR...
  26. doi High sensitivity of beta-cell replication to the inhibitory effects of interleukin-1beta: modulation by adenoviral overexpression of IGF2 in rat islets
    Elisabet Estil les
    Laboratory of Diabetes and Experimental Endocrinology, Department of Clinical Sciences, IDIBELL University of Barcelona, Feixa Llarga s n 08907 L Hospitalet de Llobregat, Barcelona, Spain
    J Endocrinol 203:55-63. 2009
    ..b>IGF2 stimulates beta-cell proliferation and survival...
  27. doi Loss of imprinting of IGF2 characterises high IGF2 mRNA-expressing type of fibroblast-like synoviocytes in rheumatoid arthritis
    Alejandro Martin-Trujillo
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Rheum Dis 69:1239-42. 2010
    Increased expression of insulin-like growth factor 2 (IGF2) by fibroblast-like synoviocytes (FLS) was associated with low inflammatory synovium of patients with rheumatoid arthritis (RA)...
  28. doi Effect of nicotine exposure during pregnancy and lactation on maternal, fetal, and postnatal rat IGF-II profile
    Andree Gruslin
    Division Maternal Fetal Medicine, Department OBS GYN and Newborn Care, The Ottawa Hospital University of Ottawa, Ontario, Canada
    Reprod Sci 16:875-82. 2009
    ..Our postnatal findings of suppressed IGF-II may help explain some of the long-term health complications seen in individuals exposed to smoking in utero...
  29. ncbi Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus
    Chikari Takeo
    Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Japan
    Endocr J 56:113-20. 2009
    ..that mRNA levels of ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2), insulin like growth factor 2 (Igf2) and insulin-like growth factor binding protein 2 (Igfbp2) were increased by estrogen in the hippocampus...
  30. doi Effect of tamoxifen treatment on global and insulin-like growth factor 2-H19 locus-specific DNA methylation in rat spermatozoa and its association with embryo loss
    Shilpa Pathak
    National Institute for Research in Reproductive Health, Indian Council for Medical Research, Mumbai, India
    Fertil Steril 91:2253-63. 2009
    To determine the effect of tamoxifen treatment on global and insulin-like growth factor 2-H19 imprinting control region (Igf2-H19 ICR)-specific DNA methylation in rat spermatozoa and analyze its association with postimplantation loss.
  31. pmc Alterations in methylation and expression levels of imprinted genes H19 and Igf2 in the fetuses of diabetic mice
    Wei Juan Shao
    Key Laboratory of Animal Physiology and Biochemistry, Nanjing Agricultural University, Nanjing, PR China
    Comp Med 58:341-6. 2008
    ..aimed to reveal alterations in expression and methylation levels of the growth-related imprinted genes H19 and Igf2 in fetuses of diabetic mice. Diabetes was induced in female mice by intraperitoneal injection of streptozotocin...
  32. ncbi Abnormal expression of insulin-like growth factor-II and its dynamic quantitative analysis at different stages of hepatocellular carcinoma development
    Li Wei Qiu
    Research Center of Clinical Molecular Biology, Affiliated Hospital of Nantong University, Nantong 226001, China
    Hepatobiliary Pancreat Dis Int 7:406-11. 2008
    ..The aim of this study was to investigate the dynamic expression of insulin-like growth factor-II (IGF-II) and its abnormal alteration in the early stages of HCC development...
  33. ncbi Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II
    H Marquardt
    J Biol Chem 256:6859-65. 1981
    A low molecular weight polypeptide with multiplication-stimulating activity (MSA) was isolated from serum-free media conditioned by a clone of normal Buffalo rat liver cells...
  34. doi Various components of the insulin-like growth factor system in tumor tissue, cerebrospinal fluid and peripheral blood of pediatric medulloblastoma and ependymoma patients
    Judith M de Bont
    Department of Pediatric Oncology and Hematology, Erasmus MC University Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
    Int J Cancer 123:594-600. 2008
    ..Larger studies should be conducted to validate the predictive values of the levels of intact IGFBP-3 and proteolytic fragments in CSF in the follow-up of medulloblastomas...
  35. ncbi Gene expression profiling distinguishes between spontaneous and radiation-induced rat mammary carcinomas
    Tatsuhiko Imaoka
    Experimental Radiobiology for Children s Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences
    J Radiat Res 49:349-60. 2008
    ..S100A9 and Pou3f3 showed high expression in a subset of radiation-induced carcinomas; and increased Gp2, Areg and Igf2 expression, as well as decreased expression of Ca3 and non-coding RNA Mg1, were common to all carcinomas...
  36. ncbi Re-emergence of a fetal pattern of insulin-like growth factor expression during hyperoxic rat lung injury
    K A Veness-Meehan
    Department of Pediatrics, University of North Carolina at Chapel Hill, 27599 7596, USA
    Am J Respir Cell Mol Biol 16:538-48. 1997
    ....
  37. ncbi Connective tissue growth factor and insulin-like growth factor 2 show upregulation in early growth plate radiorecovery response following irradiation
    Yan Wang
    Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, Syracuse, NY 13202, USA
    Cells Tissues Organs 186:192-203. 2007
    ..The hypothesis was that a limited number of growth factors and cytokines play a role in growth plate proliferative and hypertrophic chondrocyte radio-recovery...
  38. pmc Insulin-like growth factor-II regulates maternal hemodynamic adaptation to pregnancy in rats
    Tim Van Mieghem
    Department of Obstetrics and Gynecology, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Physiol Regul Integr Comp Physiol 297:R1615-21. 2009
    ..Further studies should clarify whether IGF-II directly affects vascular function and/or indirectly promotes the secretion of placenta-derived vasoactive substances...
  39. ncbi Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation
    Li Gong
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Epigenetics 5:619-26. 2010
    ..Insulin-like growth factor II (Igf2) and H19 are subject to epigenetic modifications leading to genomic imprinting...
  40. ncbi Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression
    Vesela P Kovacheva
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 282:31777-88. 2007
    ..that the prenatal choline supply affects the expression of multiple genes, including insulin-like growth factor 2 (Igf2), whose expression is regulated in a DNA methylation-dependent manner...
  41. doi Multiple system atrophy is associated with changes in peripheral insulin-like growth factor system
    Maria Teresa Pellecchia
    Department of Neurological Sciences, Federico II University, Naples, Italy
    Mov Disord 25:2621-6. 2010
    ..The aim of this study was to investigate the IGF system in patients with MSA and to evaluate correlations between this endocrine system and clinical features of the disease...
  42. pmc Expression of bone-related genes in bone marrow MSCs after cyclic mechanical strain: implications for distraction osteogenesis
    Meng chun Qi
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China
    Int J Oral Sci 1:143-50. 2009
    ..Understanding the response of mesenchymal stem cells (MSCs) to mechanical strain and their consequent gene expression patterns will broaden our knowledge of the mechanobiology of distraction osteogenesis...
  43. ncbi Insulin-like growth factor II precursor gene organization in relation to insulin gene family
    T J Dull
    Nature 310:777-81. 1984
    ..As this polypeptide, termed multiplication stimulating activity (MSA), differs from human IGF-II by only five amino acid residues, MSA probably represents the rat ..
  44. doi Differential gene expression and immunolocalization of insulin-like growth factors and insulin-like growth factor binding proteins between experimental nonunions and standard healing fractures
    Akihiro Koh
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    J Orthop Res 29:1820-6. 2011
    ..In contrast, that of IGFBP-6 was barely detected in the fracture callus. In conclusion, our results suggest that IGFs/IGFBPs may have important roles not only in fracture healing but also in nonunion formation...
  45. pmc Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA
    M B Soares
    Nucleic Acids Res 13:1119-34. 1985
    ..75 and 1.1 kb). All four RNAs are differentially expressed in all of the neonatal tissues that were examined, while the 3.4 kb pre-pro-rIGF-II mRNA and the 1.1 kb transcript are absent from adult tissues...
  46. ncbi A new leader exon identified in the rat insulin-like growth factor II gene
    T Ueno
    Department of Biochemistry, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 148:344-9. 1987
    ....
  47. ncbi Structure of the rat insulin-like growth factor II transcriptional unit: heterogeneous transcripts are generated from two promoters by use of multiple polyadenylation sites and differential ribonucleic acid splicing
    L Chiariotti
    Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio, Nazionale delle Ricerche, Universita Degli Studi Di Napoli, Italy
    Mol Endocrinol 2:1115-26. 1988
    ..These posttranscriptional modifications of RNAs arising from the rIGF-II transcription unit may generate molecules with different functional potential...
  48. ncbi Transcriptional deviation of the rat insulin-like growth factor II gene initiated at three alternative leader-exons between neonatal tissues and ascites hepatomas
    T Ueno
    Department of Biochemistry, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 950:411-9. 1988
    Insulin-like growth factor II (IGFII) is a mitogenic polypeptide, the mRNAs of which are present in multiple forms, despite derivation from a single gene...
  49. ncbi Structure and expression of the rat insulin-like growth factor II (rIGF-II) gene. rIGF-II RNAs are transcribed from two promoters
    R Frunzio
    J Biol Chem 261:17138-49. 1986
    ..The two promoters are transcribed with different efficiencies but exhibit similar tissue-specific expression and regulation with developmental age...
  50. ncbi Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors
    A L Brown
    Molecular, Cellular, and Nutritional Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892
    J Biol Chem 264:5148-54. 1989
    ..Thus, the rat IGF binding protein that we have cloned appears to be a distinct member of a family of related IGF binding proteins. We postulate that the structurally distinct IGF binding proteins may have different biological functions...
  51. ncbi Rat insulin-like growth factor II gene. A single gene with two promoters expressing a multitranscript family
    M B Soares
    J Mol Biol 192:737-52. 1986
    ..The possible occurrence of differential splicing or differential polyadenylation (or both) in this region is discussed...
  52. ncbi The primary structure of the rat insulin-like growth factor II gene region
    K Ikejiri
    Department of Biochemistry, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 1049:350-3. 1990
    ..They were: (1) twelve repetitions of about 100 base pair (bp) units; (2) duplication of 60 bp units; (3) triplication of a 24 bp unit; and (4) 41-fold expansion of 12-15 bp units...
  53. ncbi Brain insulin-like growth factor-II mRNA content is reduced in insulin-dependent and non-insulin-dependent diabetes mellitus
    L Wuarin
    Department of Physiology, Colorado State University, Fort Collins 805231, USA
    J Neurochem 67:742-51. 1996
    ..We speculate that this early biochemical lesion may contribute to the development of diabetic encephalopathy...
  54. ncbi Insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosis
    Robert Z Spaczynski
    Department of Gynecology and Obstetrics, Division of Infertility and Reproductive Endocrinology, Poznan University of Medical Sciences, 60 535 Poznan, Poland
    Mol Hum Reprod 11:319-24. 2005
    ..Moreover, excessive levels of insulin and free IGFs may lead to T-I cell hyperplasia characteristic of conditions such as polycystic ovary syndrome...
  55. ncbi Insulin-like growth factors and their binding proteins in the circulation of patients with echinococcosis, trichinellosis and toxoplasmosis
    Olgica Nedić
    INEP Institute for the Application of Nuclear Energy, Banatska 31b, 11080 Zemun, Yugoslavia
    Clin Chim Acta 335:83-8. 2003
    ..The liver is regarded as the main source of circulating forms and the levels change in various disease states. The aim of the study was to explore the effects of parasitic infections on the circulating IGFs and IGFBPs...
  56. ncbi Changes in the mRNA expressions of insulin-like growth factors, their receptors, and binding proteins during the postnatal development of rat masseter muscle
    Takashi Saito
    Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine, Yokohama, Japan
    Zoolog Sci 20:441-7. 2003
    ..Thus, the drastic changes in the quantities of IGF, IGFR, and IGFBP mRNAs in the rat masseter muscle between 14 and 19 days of age seem to be involved in the shift of rat feeding behavior...
  57. ncbi The insulin-like growth factor axis in children with inflammatory bowel disease
    Mark R Corkins
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, 702 Barnhill Drive, Room ROC 4210, Indianapolis, IN 46202 5225, USA
    J Pediatr Gastroenterol Nutr 36:228-34. 2003
    ..Malnutrition and inflammation alter the IGF axis. The authors evaluated circulating IGFs and IGFBPs in patients with inflammatory bowel disease (IBD) at the time of presentation and compared them with values obtained during remission...
  58. ncbi Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males
    T R Gaunt
    Human Genetics Research Division, University of Southampton School of Medicine, Duthie Building MP 808, Southampton General Hospital, Tremona Road, Southampton S016 6YD, UK
    Hum Mol Genet 10:1491-501. 2001
    We previously demonstrated an association between the insulin-like growth factor 2 (IGF2) gene 3'-untranslated region (3'-UTR) ApaI polymorphism and body mass index (BMI) in over 2500 middle-aged Caucasoid males...
  59. ncbi Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes
    O Kecha-Kamoun
    University of Liege, Department of Medicine and Center of Immunology, Institute of Pathology CHU B23, B 4000 Liege 1 Sart Tilman, Belgium
    Diabetes Metab Res Rev 17:146-52. 2001
    ..This hypothesis was investigated in a classic animal model of type 1 diabetes, the Bio-Breeding (BB) rat...
  60. pmc Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1
    L Gu
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699, USA
    J Clin Invest 97:777-88. 1996
    ....
  61. ncbi The insulin-like growth factor system in human immunodeficiency virus infection: relations to immunological parameters, disease progression, and antiretroviral therapy
    S I Helle
    Department of Oncology, Haukeland University Hospital, N 5021 Bergen, Norway
    J Clin Endocrinol Metab 86:227-33. 2001
    ..Our results reveal several alterations in the IGF system during HIV infection with decreased IGF-II levels, increased concentration of IGFBP-2, and an increased IGFBP-3 protease activity in advanced disease...
  62. ncbi Effects of maternal undernutrition on lung growth and insulin-like growth factor system expression in rat offspring
    Chung Ming Chen
    Department of Pediatrics, Taipei Medical University Hospital, Taiwan
    Acta Paediatr Taiwan 48:62-7. 2007
    ..Maternal undernutrition may alter the development of the lung structure in rat offspring...
  63. ncbi NMDA receptor mediated changes in IGF-II gene expression in the rat brain after injury and the possible role of nitric oxide
    M Giannakopoulou
    Laboratory of Biology Biochemistry, Faculty of Nursing, University of Athens, Athens, Greece
    Neuropathol Appl Neurobiol 26:513-21. 2000
    ..These results suggest that IGF-II, c-fos, NMDA receptors and nNOS are involved in the cellular responses to brain injury...
  64. pmc Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes
    J C Devedjian
    Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    J Clin Invest 105:731-40. 2000
    ..These results indicate that local overexpression of IGF-II in islets might lead to type 2 diabetes and that islet hyperplasia and hypersecretion of insulin might occur early in the pathogenesis of this disease...
  65. ncbi Uptake of circulating insulin-like growth factor-I into the cerebrospinal fluid of normal and diabetic rats and normalization of IGF-II mRNA content in diabetic rat brain
    C S Armstrong
    Department of Biochemistry and Molecular Biology and Department of Physiology, Colorado State University, Fort Collins 80523, USA
    J Neurosci Res 59:649-60. 2000
    ..These data support the hypothesis that circulating IGF-I supports the brain indirectly through regulation of IGF-II gene expression as well as by uptake into the CSF...
  66. ncbi Insulin-like growth factors and binding proteins in multiple sclerosis plaques
    D Gveric
    The Multiple Sclerosis Laboratory, Institute of Neurology, London, UK
    Neuropathol Appl Neurobiol 25:215-25. 1999
    ..As the remyelinating capacity of oligodendrocytes could be impaired owing to the absence of IGF-IR, the prevailing role of IGFs in inflammatory demyelination may be to promote phagocytosis of myelin and astrogliosis...
  67. ncbi Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat
    E St Lezin
    Department of Laboratory Medicine, University of California, San Francisco, USA
    Hypertension 30:854-9. 1997
    ..To investigate this possibility, we replaced a region of chromosome 1 in the SHR (defined by the markers D1Mit3 and Igf2) with the corresponding chromosome segment from the normotensive Brown-Norway (BN) strain...
  68. ncbi Insulin-like growth factor (IGF) gene expression is reduced in neural tissues and liver from rats with non-insulin-dependent diabetes mellitus, and IGF treatment ameliorates diabetic neuropathy
    H X Zhuang
    Department of Physiology, Colorado State University, Fort Collins 80523, USA
    J Pharmacol Exp Ther 283:366-74. 1997
    ..These data suggest that IGF treatment may provide rational therapy for diabetic neuropathy and that therapy may be effective even in patients unable to adequately control their hyperglycemia...
  69. ncbi Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18
    P Kovacs
    Department of Laboratory Animal Sciences, Institute of Pathophysiology, University of Greifswald, Karlsburg, Germany
    Biochem Biophys Res Commun 235:343-8. 1997
    ..The strongest evidence for linkage was observed between loci Igf2 and D1Mgh12...
  70. ncbi Functional analysis of multiple promoters of the rat insulin-like factor II gene
    T Matsuguchi
    Department of Biochemistry, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 1048:165-70. 1990
    ....
  71. ncbi Activation of endoproteolytic processing of insulin-like growth factor-II in fetal, early postnatal, and pregnant rats and persistence of circulating levels in postnatal life
    Qing Qiu
    Department of Obstetrics and Gynecology, The Ottawa Hospital, 501 Smyth Road, Ottawa, Ontario, Canada
    Endocrinology 148:4803-11. 2007
    ..g. mature IGF-II) that are required for their distinct biological functions. Taken together, our data also suggest that serum IGF-II profiles may reflect underlying physiological conditions...
  72. ncbi Concentrations of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3), IGF, and IGFBP-3 protease activity in cerebrospinal fluid of children with leukemia, central nervous system tumor, or meningitis
    H L Muller
    Department of Pediatrics, Stanford University School of Medicine, California 94305
    J Clin Endocrinol Metab 77:1113-9. 1993
    ..More likely possibilities are 1) local production of IGFBP-3 by CNS tumor tissue and secretion into the CSF, or 2) local production of IGFBP-3 by malignant cells within the CSF...
  73. ncbi Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes
    S Calderari
    Laboratory of Physiopathology of Nutrition, UMR CNRS 7059, University of Paris 7, 2 place Jussieu, 75251, Paris Cedex 05, France
    Diabetologia 50:1463-71. 2007
    ..5 and E18.5; (2) IGF2 and IGF1 receptor (IGF1R) pancreatic protein production on E13.5 and E18...
  74. ncbi [The role of insulin-like growth factor-2 gene differentially methylated regions in TCDD-induced malformation]
    Jun Wang
    Department of Medical Genetics, China Medical University, Shenyang, Liaoning, 110001 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:162-6. 2007
    ..7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on the development of fetal rats and to explore the relationship between TCDD-induced abnormal development in rats and the expression and the methylation of insulin-like growth factor 2 gene (Igf2).
  75. ncbi Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation
    Shin Da Lee
    School of Physical Therapy, China Medical University, Taichung, Taiwan
    Am J Physiol Endocrinol Metab 291:E306-14. 2006
    ..The increased cardiac IGF-II, IGF-IIR, caspase 9, and cellular apoptosis were also found in hypertensive rats with abdominal aorta ligation...
  76. ncbi [Changes of serum and cerebrospinal fluid insulin-like growth factor-II levels in neonates with hypoxic-ischemic encephalopathy]
    Bo Bai
    Department of Neonatology, Huadu District People s Hosptial, Guangzhou 510800, China
    Zhongguo Dang Dai Er Ke Za Zhi 8:187-90. 2006
    ..This study was designed to observe the changes of serum and cerebrospinal fluid (CSF) IGF-II levels in neonates with hypoxic-ischemic encephalopathy (HIE) and to investigate its effects on HIE...
  77. ncbi Insulin-like growth factor II is induced during wound repair following hypoxic-ischemic injury in the developing rat brain
    E J Beilharz
    Department of Paediatrics, Auckland University, New Zealand
    Brain Res Mol Brain Res 29:81-91. 1995
    ..IGF-II IR was associated with non-neuronal cells that appeared to be microglial-like cells and astrocytes. Together these data suggest that IGF-II may modulate the response of glial cells during recovery from cerebral infarction...
  78. ncbi Gastrointestinal inflammation and the circulating IGF system in humans
    I Baricevic
    Institute for the Application of Nuclear Energy INEP, Banatska 31b, Belgrade, Serbia and Montenegro
    Horm Metab Res 38:22-7. 2006
    ..These findings may help towards a better understanding of the metabolic outcome of the inflammatory process, and possibly in predicting the efficiency of patient recovery...
  79. ncbi The insulin-like growth factor system and markers of inflammation in adult patients with inflammatory bowel disease
    M Eivindson
    Department of Medicine, Vejle Hospital, Vejle, Denmark
    Horm Res 64:9-15. 2005
    ..Recent studies have demonstrated significant changes in the IGF system in IBD patients. The aim of the present study was to investigate correlations between the IGF system and markers of inflammation in IBD...
  80. ncbi Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions
    Cunming Duan
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Gen Comp Endocrinol 142:44-52. 2005
    ..In this article, we provide a brief overview of our current understanding of the IGF signaling system with particular reference to IGFBPs...
  81. ncbi Inverse correlation between insulin-like growth factor (IGF)-binding protein-5 and IGF-I and II during postnatal development of the anterior pituitary gland
    Silvia González-Parra
    Department of Pediatrics, Subdivision of Molecular Endocrinology, Erasmus University Rotterdam, The Netherlands
    Horm Res 57:10-4. 2002
    ..Because IGF-binding protein-5 (IGFBP-5) is one of the most highly expressed binding proteins in the anterior pituitary (AP), it might be of special importance in this gland...
  82. pmc Expression of IGF-II in early experimental hepatocellular carcinomas and its significance in early diagnosis
    Zheng Wang
    Department of Pathology, Tongji Medical College, 13 Hangkong Road, Wuhan 430030, Hubei Province, China
    World J Gastroenterol 9:267-70. 2003
    ..To investigate the serum level and expression of insulin growth factor II (IGF-II) in liver tissues of rats with early experimental hepatocellular carcinomas (HCC) and its significance in early diagnosis...
  83. ncbi Enhancement of AG1024-induced H9c2 cardiomyoblast cell apoptosis via the interaction of IGF2R with Galpha proteins and its downstream PKA and PLC-beta modulators by IGF-II
    Chun Hsien Chu
    Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan, Republic of China
    Chin J Physiol 52:31-7. 2009
    ..Improving IGF1R activity and suppressing IGF2R may be a good strategy to prevent the progression of heart disease with cardiomyocyte apoptosis...
  84. ncbi Hepatocellular carcinomas of the albumin SV40 T-antigen transgenic rat display fetal-like re-expression of lgf2 and deregulation of H19
    Matthew J Czarny
    McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA
    Mol Carcinog 46:747-57. 2007
    ..7-4.3, a region which contains the imprinted and coordinately regulated genes Igf2 and H19...
  85. ncbi Isolation of a cDNA clone encoding rat insulin-like growth factor-II precursor
    H J Whitfield
    Nature 312:277-80. 1984
    ..Our results indicate that pro-rIGF-II is synthesized as a 156 amino acid peptide precursor (17,619 Mr) containing mature rIGF-II 1-67 at its amino-terminus and an 89-residue carboxy-terminal peptide extension...
  86. ncbi Insulin-like growth factor I and II expression and modulation in amoeboid microglial cells by lipopolysaccharide and retinoic acid
    C Kaur
    Department of Anatomy, Yong Loo Lin School of Medicine, Blk MD10, 4 Medical Drive, National University of Singapore, Singapore 117597
    Neuroscience 138:1233-44. 2006
    ....
  87. ncbi Changes in the antioxidant defense and hepatic drug metabolizing enzyme and isoenzyme levels, 8-hydroxydeoxyguanosine formation and expressions of c-raf.1 and insulin-like growth factor II genes during the stages of development of hepatocellular carcinoma
    Biswajit Mukherjee
    Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India
    Eur J Cancer Prev 16:363-71. 2007
    ..It has been established that c-raf.1-induced signaling pathways activated by insulin-like growth factor II is implicated in the late stage of development of cancer...
  88. ncbi Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats
    M R Garrett
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614 5804 USA
    Genome Res 8:711-23. 1998
    ..Interactions between each QTL and every other locus in the genome scan yielded significant interactions between chromosomes 10 and 4, and between chromosomes 2 and 3...
  89. doi Abnormal Igf2 gene in Prague hereditary hypertriglyceridemic rats: its relation to blood pressure and plasma lipids
    Michaela Kadlecová
    Institute of Physiology, Academy of Sciences of the Czech Republic and Cardiovascular Research Center, Prague 4, Czech Republic
    Mol Cell Biochem 314:37-43. 2008
    ..derived from HTG and Lewis progenitors to investigate the relationship between respective polymorphism(s) of Igf2 gene and blood pressure (BP) or other cardiovascular phenotypes...
  90. ncbi Multiple polyadenylation sites in a large 3'-most exon of the rat insulin-like growth factor II gene
    T Ueno
    Department of Biochemistry, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 1009:27-34. 1989
    ..Thus, the main parts of submature materials are a collection of discrete species of RNAs, most, if not all, of which are produced by alternative polyadenylation site selection...
  91. doi Undernutrition of the GK rat during gestation improves pancreatic IGF-2 and beta-cell mass in the fetuses
    Elisa Fernández-Millán
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Barcelona, Spain
    Growth Factors 27:409-18. 2009
    ..Further studies are needed to determine whether maternal undernutrition is sufficient to delay or decrease the risk of the GK rat for developing diabetes...

Research Grants2

  1. IGF-I and its binding proteins in vascular smooth muscle cells
    Cunming Duan; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  2. ETHANOL, INSULIN/IGF SIGNALING AND NEURONAL MIGRATION
    Suzanne de la Monte; Fiscal Year: 2008
    ..abstract_text> ..