Igf1

Summary

Gene Symbol: Igf1
Description: insulin-like growth factor 1
Alias: IGF, insulin-like growth factor I, IGF-I, somatomedin
Species: rat

Top Publications

  1. ncbi Differential expression of TNF-alpha, IL-6, and IGF-1 by graded mechanical stress in normal rat myocardium
    Emiliano A Palmieri
    Department of Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, L Califano Facoltà di Medcina e Chirurgia, Universita degli Studi di Napoli Federico II, Naples, Italy
    Am J Physiol Heart Circ Physiol 282:H926-34. 2002
  2. ncbi Immunohistochemical localisation of growth hormone (GH), GH receptor (GHR), insulin-like growth factor I (IGF-I) and type I IGF-I receptor, and gene expression of GH and GHR in rat pre-antral follicles
    J Zhao
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Zygote 10:85-94. 2002
  3. ncbi Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2
    Kyung Song
    Ireland Cancer Center Research Laboratories and the Department of Pharmacology, Case Western Reserve University University Hospital of Cleveland, Cleveland, Ohio 44106, USA
    J Biol Chem 278:38342-51. 2003
  4. ncbi Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells
    Ken ichiro Hayashi
    Department of Neuroscience D13, Osaka University Graduate School of Medicine, Yamadaoka 2 2, Suita, Osaka 565 0871, Japan
    J Biol Chem 279:40807-18. 2004
  5. ncbi Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons
    Wen Hua Zheng
    Department of Psychiatry, Douglas Hospital Research Center, McGill University, Montreal, Quebec, Canada
    Mol Pharmacol 62:225-33. 2002
  6. ncbi Serum insulin-like growth factor I regulates brain amyloid-beta levels
    E Carro
    Laboratory of Neuroendocrinology, Cajal Institute, CSIC, Madrid, Spain
    Nat Med 8:1390-7. 2002
  7. ncbi Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neurons
    Angel Nunez
    Departamento de Morfologia, Facultad de Medicina, Universidad, Autonoma de Madrid, 28029, Spain
    J Neurophysiol 89:3008-17. 2003
  8. ncbi Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b
    Joachim Woelfle
    Molecular Medicine Division, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Biol Chem 278:22696-702. 2003
  9. ncbi Insulin-like growth factor-I and its receptor in neovascular age-related macular degeneration
    Antoinette C Lambooij
    Department of Ophthalmology, Erasmus Medical Center Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 44:2192-8. 2003
  10. ncbi Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation
    Joachim Woelfle
    Molecular Medicine Division, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Biol Chem 278:51261-6. 2003

Detail Information

Publications146 found, 100 shown here

  1. ncbi Differential expression of TNF-alpha, IL-6, and IGF-1 by graded mechanical stress in normal rat myocardium
    Emiliano A Palmieri
    Department of Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, L Califano Facoltà di Medcina e Chirurgia, Universita degli Studi di Napoli Federico II, Naples, Italy
    Am J Physiol Heart Circ Physiol 282:H926-34. 2002
    ..of myocardial expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and insulin-like growth factor (IGF)-1 and their cognate receptors...
  2. ncbi Immunohistochemical localisation of growth hormone (GH), GH receptor (GHR), insulin-like growth factor I (IGF-I) and type I IGF-I receptor, and gene expression of GH and GHR in rat pre-antral follicles
    J Zhao
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Zygote 10:85-94. 2002
    ..of cultured rat pre-antral follicles is stimulated by growth hormone (GH) and insulin-like growth factor-I (IGF-I) and that the mRNA of IGF-I and type I IGF receptor (IGFR) is present in the oocyte and wall of these follicles...
  3. ncbi Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2
    Kyung Song
    Ireland Cancer Center Research Laboratories and the Department of Pharmacology, Case Western Reserve University University Hospital of Cleveland, Cleveland, Ohio 44106, USA
    J Biol Chem 278:38342-51. 2003
    Insulin-like growth factor-I (IGF-I) and transforming growth factor-beta (TGF-beta) have been shown to be oncogenic and tumor suppressive, respectively, on prostate epithelial cells...
  4. ncbi Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells
    Ken ichiro Hayashi
    Department of Neuroscience D13, Osaka University Graduate School of Medicine, Yamadaoka 2 2, Suita, Osaka 565 0871, Japan
    J Biol Chem 279:40807-18. 2004
    Insulin-like growth factor-I (IGF-I) plays a role in mutually exclusive processes such as proliferation and differentiation in a variety of cell types...
  5. ncbi Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons
    Wen Hua Zheng
    Department of Psychiatry, Douglas Hospital Research Center, McGill University, Montreal, Quebec, Canada
    Mol Pharmacol 62:225-33. 2002
    Insulin-like growth factor-1 (IGF-1) is a trophic factor promoting cell survival by activating phosphatidylinositol 3-kinase (PI3K)/Akt kinase pathway...
  6. ncbi Serum insulin-like growth factor I regulates brain amyloid-beta levels
    E Carro
    Laboratory of Neuroendocrinology, Cajal Institute, CSIC, Madrid, Spain
    Nat Med 8:1390-7. 2002
    Levels of insulin-like growth factor I (IGF-I), a neuroprotective hormone, decrease in serum during aging, whereas amyloid-beta (Abeta), which is involved in the pathogenesis of Alzheimer disease, accumulates in the brain...
  7. ncbi Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neurons
    Angel Nunez
    Departamento de Morfologia, Facultad de Medicina, Universidad, Autonoma de Madrid, 28029, Spain
    J Neurophysiol 89:3008-17. 2003
    On systemic injection, insulin-like growth factor I (IGF-I) elicits a prolonged increase in the excitability of dorsal column nuclei (DCN) cells in the brain stem as well as other target neurons within the brain...
  8. ncbi Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b
    Joachim Woelfle
    Molecular Medicine Division, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Biol Chem 278:22696-702. 2003
    Many of the effects of growth hormone (GH) are mediated by insulin-like growth factor-I (IGF-I), a secreted peptide whose gene transcription is induced by GH by unknown mechanisms...
  9. ncbi Insulin-like growth factor-I and its receptor in neovascular age-related macular degeneration
    Antoinette C Lambooij
    Department of Ophthalmology, Erasmus Medical Center Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 44:2192-8. 2003
    The insulin-like growth factor (IGF)-I protein is a growth-promoting polypeptide that can act as an angiogenic agent in the eye...
  10. ncbi Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation
    Joachim Woelfle
    Molecular Medicine Division, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Biol Chem 278:51261-6. 2003
    ..of growth hormone (GH) on somatic growth and tissue maintenance are mediated by insulin-like growth factor-I (IGF-I), a secreted protein whose gene expression is rapidly and potently induced by GH by unknown mechanisms...
  11. pmc Expression of liver insulin-like growth factor 1 gene and its serum level in patients with diabetes
    Jian Bo Li
    Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
    World J Gastroenterol 10:255-9. 2004
    To explore the effect of diabetic duration and blood glucose level on insulin like growth factor 1 (IGF-1) gene expression and serum IGF-1 level.
  12. ncbi Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan
    J Am Geriatr Soc 53:1748-53. 2005
    To determine whether decreased serum insulin-like growth factor-1 (IGF-1) levels could be a risk factor for dementia in older people.
  13. ncbi Characterization of distinct Stat5b binding sites that mediate growth hormone-stimulated IGF-I gene transcription
    Dennis J Chia
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 281:3190-7. 2006
    A key agent in the anabolic actions of growth hormone (GH) is insulin-like growth factor-I (IGF-I), a 70-amino acid secreted protein with direct effects on somatic growth and tissue maintenance and repair...
  14. ncbi Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function
    Q Ding
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 140:823-33. 2006
    ..Our results illustrate a possible mechanism by which insulin-like growth factor-I interfaces with the brain-derived neurotrophic factor system to mediate exercise-induced synaptic and cognitive plasticity...
  15. ncbi An igf-I gene polymorphism modifies the risk of diabetic retinopathy
    Ingrid Rietveld
    Department of Internal Medicine, Erasmus Medical Center, Room D 436, Dr Molewaterplein 40, 3015 GD, Rotterdam, Netherlands
    Diabetes 55:2387-91. 2006
    The role of IGF-I in the pathogenesis of diabetic retinopathy is unclear...
  16. ncbi Insulin-like growth factor-1 is an endogenous mediator of focal ischemia-induced neural progenitor proliferation
    Yi Ping Yan
    Department of Neurological Surgery, University of Wisconsin Madison, WI 53792, USA
    Eur J Neurosci 24:45-54. 2006
    ..Of these, insulin-like growth factor-1 (IGF-1) showed increased protein expression in the activated astrocytes in the ischemic penumbra...
  17. ncbi Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats
    Alexander Scott
    University of British Columbia, Vancouver, British Columbia, Canada
    Arthritis Rheum 56:871-81. 2007
    ..To investigate tenocyte regulatory events during the development of overuse supraspinatus tendinosis in rats...
  18. ncbi Early downregulation of IGF-I decides the fate of rat retinal ganglion cells after optic nerve injury
    Keiko Homma
    Department of Molecular Neurobiology, Graduate School of Medicine, Kanazawa University, Kanazawa 920 8640, Japan
    Neurochem Int 50:741-8. 2007
    ..Furthermore, amount of insulin-like growth factor-I (IGF-I), an activator of the phosphatidyl inositol-3-kinase (PI3K)/Akt system, was initially decreased from RGCs 1-2 ..
  19. doi Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1
    Xi Yong Yu
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong 510080, PR China
    Biochem Biophys Res Commun 376:548-52. 2008
    ..could induce apoptosis of rat cardiomyocyte cell line H9C2 through microRNA regulated insulin-like growth factor (IGF-1) signaling pathway...
  20. doi Upregulated expression of miR-1/miR-206 in a rat model of myocardial infarction
    Zhi xin Shan
    Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, China
    Biochem Biophys Res Commun 381:597-601. 2009
    ..miR-1 and miR-206 expression were significantly increased, and insulin-like growth factor 1 (IGF-1) protein was markedly reduced without obvious change of its mRNA level after MI induction...
  21. pmc Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats
    Shuying Lin
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Exp Neurol 217:361-70. 2009
    ..rhIGF-1 enhanced proliferation of neuronal and oligodendroglial progenitors after cerebral HI as well. These data suggest that iN administration of IGF-1 has the potential to be used for clinical treatment.
  22. pmc Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I
    Michelle M Adams
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    Growth Factors 27:181-8. 2009
    Insulin-like growth factor-I (IGF-I), a functionally important neurotrophic factor, impacts tissues throughout the body including the central nervous system...
  23. pmc IGF-1 derived small neuropeptides and analogues: a novel strategy for the development of pharmaceuticals for neurological conditions
    Jian Guan
    Liggins Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Br J Pharmacol 157:881-91. 2009
    Insulin-like growth factor-1 (IGF-1) is neuroprotective and improves long-term function after brain injury...
  24. pmc Insulin-like growth factor-I prevents the accumulation of autophagic vesicles and cell death in Purkinje neurons by increasing the rate of autophagosome-to-lysosome fusion and degradation
    Mona Bains
    From the Department of Pharmacology, University of Colorado Denver, Aurora, Colorado 80045 6511, USA
    J Biol Chem 284:20398-407. 2009
    ..Here, we report that insulin-like growth factor-I (IGF-I) completely blocked the autophagy-associated cell death of Purkinje neurons...
  25. doi Serum levels of IGF1 are a useful predictor of retinopathy of prematurity
    A Pérez-Muñuzuri
    Neonatology Service, Clinical Hospital of Santiago de Compostela, Department of Paediatrics, University of Santiago de Compostela, Santiago de Compostela, Spain
    Acta Paediatr 99:519-25. 2010
    To ascertain whether insulin-like growth factor 1 (IGF1) is associated with retinopathy of prematurity (ROP) and is a useful predictor of the disease...
  26. pmc Dispersed Chromosomal Stat5b-binding elements mediate growth hormone-activated insulin-like growth factor-I gene transcription
    Dennis J Chia
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Biol Chem 285:17636-47. 2010
    ..We conclude that GH stimulates recruitment of Stat5b to multiple dispersed regions within the igf1 locus, including several with properties consistent with long range transcriptional enhancers that collectively ..
  27. pmc Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort
    Ravikanth Metlapally
    Center for Human GeneticsDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 51:4476-9. 2010
    ..modulated animal models, and observations of glycemic control in humans suggests that insulin-like growth factor (IGF)-1 plays a role in the control of eye growth...
  28. ncbi Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain
    S J Soscia
    Department of Pathology, Pierre Galletti Research Building, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA
    Cell Mol Life Sci 63:2039-56. 2006
    ..dose-effects on cerebellar development, expression of genes required for insulin and insulin-like growth factor (IGF) signaling, and the upstream mechanisms and downstream consequences of impaired signaling in relation to ..
  29. ncbi IGF-1 stimulates de novo fatty acid biosynthesis by Schwann cells during myelination
    Guoying Liang
    Division of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    Glia 55:632-41. 2007
    ..Insulin-like growth factor-1 (IGF-1) has been identified as a growth factor that stimulates the early events of myelination in SCs that signals via ..
  30. ncbi Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints
    Kari J Ekenstedt
    Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    Arthritis Rheum 54:3850-8. 2006
    To determine the effects of chronic deficiency of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) on osteoarthritis (OA) severity.
  31. ncbi Central insulin-like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats
    Brigitte J Todd
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biol Reprod 77:492-503. 2007
    ..of the LH surge in ovariectomized female rats requires concurrent activation of brain insulin-like growth factor 1 (IGF1) receptors...
  32. doi Age-impaired fluid homeostasis depends on the balance of IL-6/IGF-I in the rat supraoptic nuclei
    K Palin
    Laboratoire PsyNuGen, CNRS UMR5226, Universite de Bordeaux, INRA UMR1286, IFR8 Neurosciences, UFR de Pharmacie, 146 rue Leo Saignat, Bordeaux F 33077, France
    Neurobiol Aging 30:1677-92. 2009
    ..Conversely, insulin-like growth factor (IGF)-I, known to exhibit anti-inflammatory properties, decreases with age...
  33. doi MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats
    X H Wang
    Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China
    Clin Exp Pharmacol Physiol 36:181-8. 2009
    ..factors and/or receptors, including kinase insert domain containing receptor (Flk-1), insulin-like growth factor 1 (IGF-1) and insulin-like growth factor 1 receptor (IGF-1R)...
  34. doi Changes of human menisci in osteoarthritic knee joints
    Y Katsuragawa
    Department of Orthopaedic Surgery, National Center for Global Health and Medicine, Tokyo, Japan
    Osteoarthritis Cartilage 18:1133-43. 2010
    ..To investigate the changes of knee menisci in osteoarthritis (OA) in human...
  35. doi Comparative analysis of aqueous humor cytokine levels between patients with exudative age-related macular degeneration and normal controls
    Dong Min Cha
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    Invest Ophthalmol Vis Sci 54:7038-44. 2013
    ..To investigate the cytokine markers associated with exudative AMD present in aqueous humor. This goal was achieved by comparing the concentrations of more than 500 molecules in aqueous humor, between exudative AMD patients and controls...
  36. doi Role of IGF-1 in cortical plasticity and functional deficit induced by sensorimotor restriction
    Julien Mysoet
    Laboratoire Activité Physique, Muscle et Santé, EA 4488, IFR 114, Universite Lille 1, Sciences et Technologies, F 59650 Villeneuve d Ascq, France Unité de Recherche Pluridisciplinaire Sport, santé, Société URePSSS, Universite Lille Nord de France, F 59000 Lille, France Electronic address
    Behav Brain Res 290:117-23. 2015
    ..Recently, our team has demonstrated that IGF-1 level was decreased in the somatosensory cortex of rats submitted to a 14-day period of HU...
  37. ncbi Insulin-like growth factor-1: a prognostic factor of knee osteoarthritis
    J S Schouten
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Br J Rheumatol 32:274-80. 1993
    ..After 12 years a follow-up study was conducted to study the effect of circulating insulin-like growth factor-1 (IGF-1) on cartilage loss, osteophyte growth and overall progression in 141 persons with confirmed ROA of the knee...
  38. ncbi Expression of insulin-like growth factor I messenger ribonucleic acid in developing osteophytes in murine experimental osteoarthritis and in rats inoculated with growth hormone-secreting tumor
    K Okazaki
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Endocrinology 140:4821-30. 1999
    ..The aim of this study was to investigate insulin-like growth factor I (IGF-I) involvement in osteophyte formation...
  39. ncbi Co-administration of finasteride and the pure anti-oestrogen ICI 182,780 act synergistically in modulating the IGF system in rat prostate
    H Huynh
    Molecular Endocrinology Laboratory, Division of Cellular and Molecular Research, National Cancer Centre, Singapore 169610
    J Endocrinol 171:109-18. 2001
    ..We report herein that the pure anti-oestrogen ICI 182,780 (ICI) reduces Ki-67 labelling index and IGF-I receptor levels in rat prostate...
  40. ncbi Influence of varying degrees of malnutrition on IGF-I expression in the rat diaphragm
    Michael I Lewis
    Division of Pulmonary Critical Care Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Appl Physiol (1985) 95:555-62. 2003
    ..study evaluated the impact of varying degrees of prolonged malnutrition on the local insulin-like growth factor-I (IGF-I) system in the costal diaphragm muscle...
  41. ncbi NO plays a role in LPS-induced decreases in circulating IGF-I and IGFBP-3 and their gene expression in the liver
    Teresa Priego
    Departamento de Fisiologia, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Am J Physiol Endocrinol Metab 286:E50-6. 2004
    ..inducible nitric oxide synthase (iNOS) inhibitor, to study the role of nitric oxide (NO) in LPS-induced decrease in IGF-I and IGFBP-3...
  42. ncbi Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes
    Ashok K Shetty
    Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Glia 51:173-86. 2005
    ..We measured the concentrations of fibroblast growth factor-2 (FGF-2), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF) in the hippocampus of young, middle-aged, and aged F344 rats, ..
  43. ncbi The relationship of retinal VEGF and retinal IGF-1 mRNA with neovascularization in an acidosis-induced model of retinopathy of prematurity
    David A Leske
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Curr Eye Res 31:163-9. 2006
    ..We studied the relationship of vascular endothelial growth factor (VEGF) retinal mRNA and insulin-like growth factor-1 (IGF-1) retinal mRNA expression with the emergence of neovascularization (NV) in AIR.
  44. ncbi An insulin-like growth factor-I promoter polymorphism is associated with increased mortality in subjects with myocardial infarction in an elderly Caucasian population
    Mojgan Yazdanpanah
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Cardiol 97:1274-6. 2006
    We investigated whether an insulin-like growth factor I (IGF-I) promoter polymorphism is associated with excess mortality in elderly subjects with myocardial infarction (MI)...
  45. pmc Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction
    Michael E Davis
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Proc Natl Acad Sci U S A 103:8155-60. 2006
    ..injury, we designed self-assembling peptide nanofibers for prolonged delivery of insulin-like growth factor 1 (IGF-1), a cardiomyocyte growth and differentiation factor, to the myocardium, using a "biotin sandwich" approach...
  46. ncbi Effects of maternal undernutrition on lung growth and insulin-like growth factor system expression in rat offspring
    Chung Ming Chen
    Department of Pediatrics, Taipei Medical University Hospital, Taiwan
    Acta Paediatr Taiwan 48:62-7. 2007
    ..Maternal undernutrition may alter the development of the lung structure in rat offspring...
  47. doi Effect of electrical stimulation on IGF-1 transcription by L-type calcium channels in cultured retinal Müller cells
    Tatsuhiko Sato
    Department of Applied Visual Science, Osaka University Medical School, Suita, Osaka, Japan
    Jpn J Ophthalmol 52:217-23. 2008
    To investigate the effect of electrical stimulation (ES) on the induction of insulin-like growth factor 1 (IGF-1) in cultured retinal Müller cells.
  48. doi Immunolocalization of insulin-like growth factors and their receptors in the diabetic mouse oviduct and uterine tissues during the preimplantation period
    Rahimah Zakaria
    School of Medical Sciences, Universiti Sains Malaysia, 16150 Kota Bharu, Kelantan, Malaysia
    Acta Histochem 111:52-60. 2009
    The aim of the present study was to analyze the immunolocalization of insulin-like growth factor (IGF)-1 and IGF-2 and their receptors in the oviduct and uterus of control and diabetic mice...
  49. doi Setting the pace for retinal development: environmental enrichment acts through insulin-like growth factor 1 and brain-derived neurotrophic factor
    Silvia Landi
    Laboratorio di Neurobiologia, Scuola Normale Superiore National Enterprise for nano Science and nanoTechnology, I 56100 Pisa, Italy
    J Neurosci 29:10809-19. 2009
    ..Here, we show that early [postnatal day 1 (P1) to P7] insulin-like growth factor 1 (IGF-1) injections in the eyes of non-EE rat pups mimic EE effects both in increasing BDNF levels in the retinal ..
  50. pmc Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3
    Betul Ersoy
    Department of Pediatrics, Division of Pediatric Endocrinology, Faculty of Medicine, Celal Bayar University, Manisa 45010, Turkey
    World J Gastroenterol 15:5418-24. 2009
    To evaluate the effects of growth hormone (GH) on the histology of small intestines which might be related to the role of insulin like growth factor (IGF)-I, IGF-binding protein 3 (IGFBP-3) and its receptors.
  51. pmc Intracellular insulin-like growth factor-1 induces Bcl-2 expression in airway epithelial cells
    Hitendra S Chand
    Chronic Obstructive Pulmonary Disease Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    J Immunol 188:4581-9. 2012
    ..captured by laser microdissection showed that increased expression of IL-1β and insulin-like growth factor-1 (IGF-1) coincided with induced Bcl-2 expression compared with controls...
  52. pmc FoxO1 and FoxM1 transcription factors have antagonistic functions in neonatal cardiomyocyte cell-cycle withdrawal and IGF1 gene regulation
    Arunima Sengupta
    The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children s Medical Center, Cincinnati, OH 45229, USA
    Circ Res 112:267-77. 2013
    ..In the mammalian heart, cardiomyocytes withdraw from the cell cycle and initiate hypertrophic growth soon after birth, but the transcriptional regulatory mechanisms that control these neonatal transitions are not well-defined...
  53. doi Enriched early life experiences reduce adult anxiety-like behavior in rats: a role for insulin-like growth factor 1
    Sara Baldini
    Laboratory of Neurobiology, Scuola Normale Superiore, Pisa, Italy
    J Neurosci 33:11715-23. 2013
    ..We recently found that insulin-like growth factor 1 (IGF-1) is a key mediator of early EE or massage on brain development...
  54. doi Expression of FGF-2 and IGF-1 in diabetic rats with fracture
    Qing Quan Chen
    Department of Orthopaedics, Fuzhou General Hospital of Nanjing Military Area, Fuzhou 350025, China
    Asian Pac J Trop Med 7:71-5. 2014
    To observe the change of fibroblast growth factor-2 (FGF-2), insulin-like growth factor-1 (IGF-1) in serum and bone callus after fracture in diabetic rats, and to explore molecular biological mechanism of healing of diabetic fracture.
  55. doi Effects of Resveratrol on Ovarian Morphology, Plasma Anti-Mullerian Hormone, IGF-1 Levels, and Oxidative Stress Parameters in a Rat Model of Polycystic Ovary Syndrome
    Mete Ergenoglu
    Department of Obstetrics and Gynecology, Ege University, Izmir, Turkey
    Reprod Sci 22:942-7. 2015
    ..To evaluate the effects of resveratrol in a rat model of polycystic ovarian syndrome (PCOS)...
  56. doi Intrauterine low-functional programming of IGF1 by prenatal nicotine exposure mediates the susceptibility to osteoarthritis in female adult rat offspring
    Kai Tie
    Department of Orthopaedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China Department of Physiology and Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, China and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China
    FASEB J 30:785-97. 2016
    ..the expression of α1 chain of type II collagen (Col2A1), aggrecan, SRY-type high mobility group box 9 (Sox9), and IGF1 signaling molecules in the cartilage of PNE offspring were decreased...
  57. doi Restorative effect of intracerebroventricular insulin-like growth factor-I gene therapy on motor performance in aging rats
    F Nishida
    Institute of Pathology, School of Veterinary Sciences, National University of La Plata, La Plata 1900, Argentina
    Neuroscience 177:195-206. 2011
    Insulin-like growth factor-I (IGF-I) is a powerful neuroprotective molecule in the brain and spinal cord. We have previously shown that intracerebroventricular (i.c.v...
  58. pmc Regulation of IGF-1 but not TGF-β1 by NGF in the smooth muscle of the inflamed urinary bladder
    Qing L Zhang
    Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA, United States
    Regul Pept 177:73-8. 2012
    ..growth factors characterized in the current study include nerve growth factor (NGF), insulin-like growth factor (IGF)-1, and transforming growth factor (TGF)-β1...
  59. doi SIRT1 silencing confers neuroprotection through IGF-1 pathway activation
    Luigi Sansone
    Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
    J Cell Physiol 228:1754-61. 2013
    The following study demonstrated that, in in vitro differentiated neurons, SIRT1 silencing induced an increase of IGF-1 protein expression and secretion and of IGF-1R protein levels which, in turn, prolonged neuronal cell survival in ..
  60. pmc Impaired insulin/IGF signaling in experimental alcohol-related myopathy
    Van Anh Nguyen
    Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA
    Nutrients 4:1058-75. 2012
    ..We hypothesize that Alc-M is mediated by combined effects of insulin/IGF resistance and oxidative stress, similar to the effects of ethanol on liver and brain...
  61. pmc IGF-1 restores visual cortex plasticity in adult life by reducing local GABA levels
    José Fernando Maya-Vetencourt
    Laboratory of Neurobiology, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56100 Pisa, Italy
    Neural Plast 2012:250421. 2012
    ..Insulin-like growth factor 1 (IGF-1) is a peptide implicated in prenatal and postnatal phases of brain development such as neurogenesis, neuronal ..
  62. doi Toxicogenomic biomarkers for renal papillary injury in rats
    Takeki Uehara
    Drug Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Toxicology 303:1-8. 2013
    ..The three top-ranked genes, Timp1, Igf1, and Lamc2, exhibited the best prediction performance in an external data set with area under the curve (AUC) ..
  63. doi Osteogenic potential of bone marrow stromal cells derived from streptozotocin-induced diabetic rats
    Yan Fang Zhao
    Department of Prosthodontics, Ninth People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Int J Mol Med 31:614-20. 2013
    ..These changes may be partially related to impaired insulin and insulin-like growth factor 1 (IGF-1) signaling...
  64. doi Changes in serotoninergic and noradrenergic descending pain pathways during painful diabetic neuropathy: the preventive action of IGF1
    Carla Morgado
    Institute of Histology and Embryology, Faculty of Medicine of Porto, IBMC, University of Porto, Alameda Professor Hernani Monteiro, 4200 319 Porto, Portugal
    Neurobiol Dis 43:275-84. 2011
    ..Since, during diabetes, the levels of insulin growth factor 1 (IGF1) decrease, reducing its neurotrophic effect in the brain, we also studied the effects of IGF1 treatment...
  65. doi Insulin-like growth factor I signaling for brain recovery and exercise ability in brain ischemic rats
    Heng Chih Chang
    Department and Institute of Physiology, National Yang Ming University, Taipei, Taiwan
    Med Sci Sports Exerc 43:2274-80. 2011
    ..neuron survival and plasticity in the adult brain by enhancing the uptake of insulin-like growth factor I (IGF-I)...
  66. ncbi Primary structure of rat insulin-like growth factor-I and its biological activities
    K Tamura
    Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, Osaka, Japan
    J Biol Chem 264:5616-21. 1989
    Rat insulin-like growth factor-I (IGF-I), a serum polypeptide with growth promoting activity, was isolated from rat serum by a combination of acid/ethanol extraction, affinity chromatography, and a series of reversed phase high ..
  67. ncbi Rat IGF-I cDNA's contain multiple 5'-untranslated regions
    C T Roberts
    Biochem Biophys Res Commun 146:1154-9. 1987
    DNA sequencing of several independent rat IGF-I cDNA clones has revealed three different 5'-untranslated region sequences which contain multiple, upstream, in-frame initiation codons...
  68. ncbi Effects of insulin-like growth factor-I and its analogue, long-R3-IGF-I, on intestinal absorption of 3-O-methyl-D-glucose are less pronounced than gut mucosal growth responses
    Sonja M Garnaut
    Cooperative Research Center for Tissue Growth and Repair, Child Health Research Institute, North Adelaide, South Australia, Australia
    Growth Factors 20:17-25. 2002
    The relationship between insulin-like growth factor-I (IGF-I) peptide-induced increases in bowel mass and functional improvement is unclear...
  69. ncbi Mesenchymal IGF-I overexpression: paracrine effects in the intestine, distinct from endocrine actions
    Kristen L Williams
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599 7080, USA
    Am J Physiol Gastrointest Liver Physiol 283:G875-85. 2002
    Local IGF-I expression is frequently increased in intestinal mesenchyme during adaptive growth of intestinal epithelium, but paracrine growth effects of IGF-I in vivo are not defined...
  70. ncbi Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic beta-cell death
    Wenli Liu
    Department of Medicine, Veterans Affairs Chicago Healthcare System, Lakeside Division, Chicago, Illinois 60611, USA
    Endocrinology 143:3802-12. 2002
    To begin to determine whether IGF-I treatment represents a potential means of enhancing the survival of islet cell grafts after transplantation, the present studies established a model of beta-cell death secondary to loss of trophic ..
  71. ncbi Preferential expression of IGF-I in small DRG neurons and down-regulation following injury
    Matthew J Craner
    Department of Neurology LCI 707 and PVA EPVA Center for Neuroscience and Regeneration Research, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Neuroreport 13:1649-52. 2002
    In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (STZ) ..
  72. ncbi Effect of high-fat diet on body composition and hormone responses to glucose tolerance tests
    J L Brown
    Department of Nutritional Sciences, Oklahoma State University, Stillwater 74078, USA
    Endocrine 19:327-32. 2002
    ..HF rats secreted more insulin and leptin compared to MF animals. Lean body mass and serum GH and IGF-I concentrations were not different between the groups...
  73. ncbi Muscular levels of proinflammatory cytokines correlate with a reduced expression of insulinlike growth factor-I in chronic heart failure
    P Christian Schulze
    Cardiovascular Research, Partners Research Facility, 65 Landsdowne Street, Room 289, Cambridge, MA 02139, USA
    Basic Res Cardiol 98:267-74. 2003
    ..To assess the role of proinflammatory cytokines for the local expression of insulin-like growth factor-I (IGF-I) in this process, muscular and systemic levels of interleukin-1 beta (IL-1beta), tumor necrosis factor alpha (..
  74. ncbi TGF-beta 1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells
    Gabriella Mincione
    Dipartimento di Oncologia e Neuroscienze, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Via dei Vestini, 31, Chieti, Italy
    Exp Cell Res 287:411-23. 2003
    Transforming growth factor beta 1 (TGF-beta 1) and insulin-like growth factor I (IGF-I) have contrasting effects on cell cycle regulation in thyroid cells and TGF-beta 1 induces a dramatic decrease in IGF-I-induced cell proliferation...
  75. ncbi Age-dependent adaptation of the liver thyroid status and recovery of serum levels and hepatic insulin-like growth factor-I expression in neonatal and adult diabetic rats
    A M Pascual-Leone
    Instituto de Bioquimica, Centro Mixto CSIC UCM, Facultad de Farmacia, Ciudad Universitaria, Madrid, Spain
    Metabolism 52:1117-25. 2003
    ..on the hepatic deiodinase (5'D-I) activity and triiodothyronine (T(3)) content and on insulin-like growth factor-I (IGF-I) secretion and mRNA hepatic expression were studied in neonatal and adult diabetic (D) rats and compared with 4 ..
  76. ncbi Increased insulin-like growth factor-I gene expression precedes left ventricular cardiomyocyte hypertrophy in a rapidly-hypertrophying rat model system
    Chi Yang Huang
    Department of Molecular and Integrative Physiology, University of Illinois, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, IL 61801, USA
    Cell Biochem Funct 21:355-61. 2003
    ..However, the molecular mechanisms underlying this hypertrophy are not understood. Insulin-like growth factor-I (IGF-I) synthesized locally in the heart is known to be associated with the hypertrophic process...
  77. ncbi Modulation of brain insulin-like growth factor I (IGF-I) binding sites and hypothalamic GHRH and somatostatin levels by exogenous growth hormone and IGF-I in juvenile rats
    Rina Eshet
    Laboratory of Endocrinology and Diabetes, Felsenstein Medical Research Center, Petah Tikva, Israel
    J Mol Neurosci 22:179-88. 2004
    The effect of exogenous growth hormone (GH) and insulin-like growth factor I (IGF-I) on brain IGF-I binding sites (IGF-IR), and on the levels of growth hormone-releasing hormone (GHRH) and somatostatin was studied in hypophysectomized ..
  78. ncbi Stimulatory effect of IGF-I and VEGF on eNOS message, protein expression, eNOS phosphorylation and nitric oxide production in rat glomeruli, and the involvement of PI3-K signaling pathway
    Ying Wang
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Nitric Oxide 10:25-35. 2004
    ..We set out to determine whether IGF-I and/or VEGF165 directly stimulate NO production in rat glomeruli and whether the expression of NO synthase (NOS) ..
  79. ncbi Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease
    Frank Fischer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Clin Endocrinol (Oxf) 61:595-602. 2004
    ..IGFs and their binding proteins (IGFBPs) are produced both systemically and locally by cells of the cardiovascular system. As growth promoters, they may play a role in atherosclerosis...
  80. ncbi Insulin-like growth factor-1 increases endothelin receptor A levels and action in cultured rat aortic smooth muscle cells
    Ching Fai Kwok
    Department of Medicine, Division of Endocrinology and Metabolism, Taipei Veterans General Hospital, Taiwan
    J Cell Biochem 94:1126-34. 2005
    ..ET-1) receptors in vascular smooth muscle cells (SMCs), but the effect of insulin-like growth factor 1 (IGF-1) on ET-1 receptor expression is not known...
  81. ncbi Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytes
    Margaret L Shumate
    Dept of Surgery, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    Am J Physiol Gastrointest Liver Physiol 289:G227-39. 2005
    Sepsis results in hepatic "growth hormone (GH) resistance" with reductions in plasma IGF-I despite a two- to fourfold increase in circulating GH...
  82. ncbi Impaired IGF-I signalling of hypertrophic hearts in the developmental phase of hypertension in genetically hypertensive rats
    Wei Wen Kuo
    Institute of Biochemistry, Chung Shan Medical University, Taichung, Taiwan
    Cell Biochem Funct 23:325-31. 2005
    Insulin-like growth factor-I (IGF-I) signalling is reported to contribute to the modulation of blood pressure and set survival and hypertrophic responses in cardiac tissue...
  83. ncbi Corticotropin-releasing factor receptor subtype 1 and somatostatin modulating hypoxia-caused downregulated mRNA of pituitary growth hormone and upregulated mRNA of hepatic insulin-like growth factor-I of rats
    Xue Qun Chen
    Division of Neurobiology and Physiology, College of Life Sciences, Zhejiang University Yuquan Campus, Hangzhou 310027, China
    Mol Cell Endocrinol 242:50-8. 2005
    ..aims to examine the effects of restraint, cold, and in combination of hypoxia on pituitary GH mRNA and hepatic IGF-I mRNA and its protein in rats, and the potential involvement of corticotropin-releasing factor receptor subtype 1 (..
  84. ncbi IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB
    Carola Maldonado
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago
    Biochem Biophys Res Commun 336:1112-8. 2005
    ..a rapid and pronounced apoptosis in cardiac myocytes which is attenuated by insulin-like growth factor-1 (IGF-1)...
  85. ncbi Insulin receptor exon 11+/- is expressed in Zucker (fa/fa) rats, and chlorogenic acid modifies their plasma insulin and liver protein and DNA
    Delcy V Rodriguez de Sotillo
    Department of Chemistry, Minnesota State University, Mankato, 56001, USA
    J Nutr Biochem 17:63-71. 2006
    ..The insulin receptor exon 11(+) and the exon 11(-) variants were expressed in the liver of Zucker (fa/fa) rats without significant changes (P>.05). Chlorogenic acid improved some cellular mechanisms that are stimulated by insulin...
  86. ncbi Insulin-like growth factor-I downregulates embryonic myosin heavy chain (eMyHC) in myoblast nuclei
    Buel D Rodgers
    Department of Animal Sciences, Washington State University, Pullman, WA 99164 6351, USA
    Growth Horm IGF Res 15:377-83. 2005
    The obscure ability of the insulin-like growth factors (IGF-I & -II) to stimulate both myoblast proliferation and differentiation suggests that the latter effect may be mediated locally, possibly by IGF binding proteins (IGFBPs)...
  87. ncbi Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade
    Yijiang Shi
    Hematology Oncology Division, West Los Angeles Veteran s Administration, West Los Angeles Hospital, and University of California at Los Angeles Medical Center 90073, USA
    Mol Cancer Ther 4:1533-40. 2005
    ..serine phosphorylation of insulin receptor substrate-1 (IRS-1), they may enhance insulin-like growth factor-I (IGF-I) signaling and downstream phosphatidylinositol 3-kinase (PI3K)/AKT activation...
  88. ncbi Sepsis and inflammatory insults downregulate IGFBP-5, but not IGFBP-4, in skeletal muscle via a TNF-dependent mechanism
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 290:R963-72. 2006
    ..In contrast, exogenous administration of IGF-I as part of a binary complex composed of IGF-I/IGFBP-3 produced comparable increases in IGFBP-5 mRNA in both ..
  89. ncbi A potential inverse association between insulin-like growth factor I and hypertension in a cross-sectional study
    Kelly J Hunt
    Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, TX, USA
    Ann Epidemiol 16:563-71. 2006
    Elevated circulating insulin-like growth factor I (IGF-I) levels increasingly are being implicated as a potential risk factor for the development of some cancers; however, relatively few epidemiologic studies have focused on potential ..
  90. ncbi Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon
    Jens L Olesen
    Institute of Sports Medicine, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    J Appl Physiol (1985) 101:183-8. 2006
    Insulin-like growth factor I (IGF-I) is known to exert an anabolic effect on tendon fibroblast production of collagen. IGF-I's regulation is complex and involves six different IGF binding proteins (IGFBPs)...
  91. ncbi Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy
    Alessandro Fanzani
    Department of Biomedical Sciences and Biotechnology, Unit of Biochemistry, University of Brescia, Italy
    FEBS J 273:3709-21. 2006
    ..Here we show that insulin-like growth factor 1 (IGF1)-induced hypertrophy of myoblasts notably increases Neu2 synthesis by activation of the phosphatidylinositol 3-..
  92. pmc IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis
    Naira Baregamian
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 0353, USA
    J Surg Res 136:31-7. 2006
    ..Insulin-like growth factor (IGF)-1 activates PI3-K pathway to promote cell survival; however, the effects of IGF-1 treatment during gut injury are ..
  93. ncbi Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development
    Eugenia Colón
    Department of Woman and Child Health, Paediatric Endocrinology Unit, Astrid Lindgren Children s Hospital, Karolinska Institute and University Hospital, SE 17176 Stockholm, Sweden
    Endocrinology 148:128-39. 2007
    The present investigation examines the influence of IGF-I and the role of IGF-I receptor (IGF-IR) in the apoptosis/survival of Leydig cells...
  94. ncbi Influence of ghrelin on gastric and duodenal growth and expression of digestive enzymes in young mature rats
    Z Warzecha
    Department of Physiology, Jagiellonian University Medical College, Krakow, Poland
    J Physiol Pharmacol 57:425-37. 2006
    ..The aim of present study was to examine the influence of ghrelin administration on gastric and duodenal growth and expression of pepsin and enterokinase in young mature rats with intact or removed pituitary...
  95. ncbi Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: differential effects of specific contraction types
    K M Heinemeier
    Institute of Sports Medicine, Bispebjerg Hospital Bldg 8, 1st Floor, 23 Bispebjerg Bakke, DK 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 102:573-81. 2007
    In skeletal muscle, an increased expression of insulin like growth factor-I isoforms IGF-IEa and mechano-growth factor (MGF) combined with downregulation of myostatin is thought to be essential for training-induced hypertrophy...
  96. ncbi The effect of insulin-like growth factor-I on hepatocyte apoptosis after bile duct ligation in rat
    Shyr Ming Sheen-Chen
    Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung College of Medicine, Chang Gung University, Tao Yuan, Taiwan
    Dig Dis Sci 51:2220-4. 2006
    ..Exogenous administration of insulin-like growth factor-I (IGF-I) has been shown to enhance mucosal adaptation after small bowel resection in rats and also to accelerate repair ..
  97. ncbi Insulin-like growth factor I (IGF-I) and its receptor (IGF-1R) in the rat anterior pituitary
    Elisabeth Eppler
    Division of Neuroendocrinology, Institute of Anatomy, University of Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Eur J Neurosci 25:191-200. 2007
    Few and controversial results exist on the cellular sites of insulin-like growth factor (IGF)-I synthesis and the type 1 IGF receptor (IGF-1R) in mammalian anterior pituitary...
  98. ncbi Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes
    Zorica Zakula
    Institute Vinca, Laboratory for Molecular Genetics and Radiobiology, 11000 Belgrade, Serbia and Montenegro
    Med Hypotheses 69:302-6. 2007
    Insulin-like growth factor-1 (IGF-1) is a hormone and growth factor closely related to insulin...
  99. ncbi Influence of dichlorodiphenylchloroethylene on vascular endothelial growth factor and insulin-like growth factor in human and rat ovarian cells
    A C Holloway
    Department of Obstetrics and Gynaecology, Reproductive Biology Division, McMaster University, Health Sciences Centre, Hamilton, ON, Canada
    Reprod Toxicol 24:359-64. 2007
    ..of DDE on the expression of the ovarian vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF-1) in primary cultures of human granulosa cells and in the rat ovary...
  100. doi Effects of brief, clustered versus dispersed hypoxic episodes on systemic and ocular growth factors in a rat model of oxygen-induced retinopathy
    Rebecca J Coleman
    Department of Pediatrics, University of California Irvine, Irvine, California 92868, USA
    Pediatr Res 64:50-5. 2008
    ..and ocular vascular endothelial growth factor (VEGF), soluble VEGFR-1 (sVEGFR-1), insulin-like growth factor I (IGF-I), and growth hormone were examined. All hyperoxia-exposed retinas had evidence of neovascularization...
  101. pmc Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice
    Ekaterina Semenova
    European Molecular Biology Laboratory EMBL Mouse Biology Unit, Campus A Buzzati Traverso, Monterotondo Scalo, Roma, Italy
    Am J Pathol 173:1295-310. 2008
    Insulin-like growth factor 1 (IGF-1) is an important regulator of growth, survival, and differentiation in many tissues. It is produced in several isoforms that differ in their N-terminal signal peptide and C-terminal extension peptide...

Research Grants15

  1. Alcohol-Induced Regulation of Hepatic Protein Synthesis
    THOMAS VARY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. IGFBP5 AND INTEGRINS AND CONTROLLING IGF1 ACTIONS
    David Clemmons; Fiscal Year: 2002
    ..of intergrin receptors and high affinity binding proteins alter the capacity of insulin-like growth factor-I (IGF-I) to stimulate smooth muscle cell (SMC) replication and migration...
  3. SEX STEROID REGULATION OF IGF-I EXPRESSION IN BONE
    Thomas McCarthy; Fiscal Year: 2003
    ..Insulin-like growth factor-I (IGF-I) is an important bone growth factor that enhances replication of less differentiated bone cells and matrix ..
  4. ARTHEROSCLEROSIS IN INSULIN-RESISTANT, HYPERLIPIDEMIC P*
    David Clemmons; Fiscal Year: 2005
    ..In Aim III, insulin like growth factor-I (IGF-1) will be given to the CH-IR pigs to reduce IR, and the pigs will be fed a high fat atherogenic diet...
  5. NEUROPATHOLOGY OF THE AGING SYMPATHETIC NERVOUS SYSTEM
    Robert Schmidt; Fiscal Year: 2006
    ..We have found that short courses of IGF-I or NT-3 result in significant reduction in established sympathetic NAD in aged rats...
  6. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2006
    ..abstract_text> ..
  7. Repair of Chronially Injured Hippocampus by Grafts
    Ashok Shetty; Fiscal Year: 2006
    ..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. [unreadable] [unreadable]..
  8. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes
    David Clemmons; Fiscal Year: 2006
    ..Insulin-like growth factor-l (IGF-I) has been implicated in initiating the proliferative phase of atherosclerotic lesion development but inhibiting ..
  9. MECHANISMS BY WHICH IGF-I STIMULATES SMOOTH MUSCLE CELLS
    David Clemmons; Fiscal Year: 2007
    The purpose of these studies is to analyze the molecular mechanisms by which insulin-like growth factor-l (IGF-I) stimulates smooth muscle cell (SMC) migration and replication...
  10. Chaperones, ROS systems, & IGF-1:Roles in vascular aging
    David Clemmons; Fiscal Year: 2008
    ..These include reduction in insulin like growth factor I (IGF-I) signaling, which in lower organisms has been shown to enhance the heatshock protein response to ..
  11. EXPERIMENTAL DIABETIC AUTONOMIC NEUROPATHY
    ROBERT EDWARD SCHMIDT; Fiscal Year: 2010
    ..In the last funding period we have shown that diabetic rat sympathetic ganglia are IGF-I deficient and have significant defects in PI3K/Akt signaling pathway intermediates which are reversed by ..
  12. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    Charles H Lang; Fiscal Year: 2010
    ..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
  13. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles H Lang; Fiscal Year: 2010
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
  14. IGF-I and its binding proteins in vascular smooth muscle cells
    Cunming Duan; Fiscal Year: 2008
    ..These diverse actions of IGFs are mediated through the IGF-I receptor (IGF-IR), a transmembrane tyrosine kinase...
  15. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2005
    ..overproduction of tumor necrosis factor (TNF)a which alters the responsiveness of the heart to insulin-like growth (IGF)-l and growth hormone (GH), To address the questions implicit in this hypothesis, the proposed research has the ..