ICAM

Summary

Gene Symbol: ICAM
Description: intercellular adhesion molecule 1
Alias: CD54, ICAM, intercellular adhesion molecule 1, ICAM-1
Species: rat

Top Publications

  1. doi Early induction of moderate hypothermia suppresses systemic inflammatory cytokines and intracellular adhesion molecule-1 in rats with caerulein-induced pancreatitis and endotoxemia
    Kenji Fujimoto
    Department of Critical Care and Emergency Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Pancreas 37:176-81. 2008
  2. ncbi Acute urinary bladder distension triggers ICAM-1-mediated renal oxidative injury via the norepinephrine-renin-angiotensin II system in rats
    Show Shing Chen
    Department of Surgery, Kuang Tien General Hospital, Taichung, Taiwan
    J Formos Med Assoc 108:627-35. 2009
  3. pmc Intercellular adhesion molecule-1-dependent neutrophil adhesion to endothelial cells induces caveolae-mediated pulmonary vascular hyperpermeability
    Guochang Hu
    Department of Pharmacology, University of Illinois College of Medicine, 835 S Wolcott Ave, Chicago, IL 60612, USA
    Circ Res 102:e120-31. 2008
  4. doi Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats
    Chin Yi Cheng
    Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
    Brain Res 1209:136-50. 2008
  5. doi Vaspin prevents TNF-α-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-κB and PKCθ activation in cultured rat vascular smooth muscle cells
    Sukanya Phalitakul
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Pharmacol Res 64:493-500. 2011
  6. pmc PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells
    Jean Pierre Couty
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Neurochem 103:793-801. 2007
  7. pmc Diminished ICAM-1 expression and impaired pulmonary clearance of nontypeable Haemophilus influenzae in a mouse model of chronic obstructive pulmonary disease/emphysema
    Bing Pang
    Departments of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Infect Immun 76:4959-67. 2008
  8. ncbi K469E polymorphism of the intracellular adhesion molecule 1 gene is associated with proliferative diabetic retinopathy in Caucasians with type 2 diabetes
    Mojca Globocnik Petrovic
    Eye Clinic, University Medical Centre Ljubljana, Slovenia
    Clin Exp Ophthalmol 36:468-72. 2008
  9. doi Involvement of the peripheral sensory and sympathetic nervous system in the vascular endothelial expression of ICAM-1 and the recruitment of opioid-containing immune cells to inhibit inflammatory pain
    Shaaban A Mousa
    Department of Anaesthesiology and Intensive Care Medicine, Charite University Berlin, Campus Virchow Klinikum and Campus Charite Mitte, Berlin, Germany
    Brain Behav Immun 24:1310-23. 2010
  10. ncbi Intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 at the early stages of atherosclerosis in a rat model
    Lampros Fotis
    Laboratory for Experimental Surgery and Surgical Research N S Christeas, Athens University Medical School, Athens, Greece
    In Vivo 26:243-50. 2012

Research Grants

  1. The Effects of Resveratrol on Presbyacusis
    Michael Seidman; Fiscal Year: 2004
  2. Baltimore VIRAHEP-C Clinical Center
    Charles Howell; Fiscal Year: 2005
  3. DETERMINANTS OF CORONARY DISEASE IN HIGH RISK FAMILIES
    Lewis Becker; Fiscal Year: 2001
  4. Alveolar Epithelium in Acute Lung Injury
    Lorraine Ware; Fiscal Year: 2005
  5. Murine CMV Pneumonitis in Allogeneic BMT
    Oliver Oakley; Fiscal Year: 2005
  6. Coronary Disease Detection by Thalluim SPECT and Fast CT
    Lewis Becker; Fiscal Year: 2006
  7. Biomarker Profiles in the Diagnosis/Prognosis of ARDS
    Lorraine Ware; Fiscal Year: 2008
  8. Genotypic Determinants of Aspirin Response in High Risk Families
    Lewis Becker; Fiscal Year: 2008
  9. Genome-Wide Association of Platelet Phenotypes
    Lewis Becker; Fiscal Year: 2009

Detail Information

Publications144 found, 100 shown here

  1. doi Early induction of moderate hypothermia suppresses systemic inflammatory cytokines and intracellular adhesion molecule-1 in rats with caerulein-induced pancreatitis and endotoxemia
    Kenji Fujimoto
    Department of Critical Care and Emergency Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Pancreas 37:176-81. 2008
    ..To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats...
  2. ncbi Acute urinary bladder distension triggers ICAM-1-mediated renal oxidative injury via the norepinephrine-renin-angiotensin II system in rats
    Show Shing Chen
    Department of Surgery, Kuang Tien General Hospital, Taichung, Taiwan
    J Formos Med Assoc 108:627-35. 2009
    ..renal sympathetic activation may contribute to inflammatory responses and end-organ damage via activation of angiotensin-II-receptor-mediated intercellular adhesion molecule-1 (ICAM-1) expression and leukocyte infiltration in the kidney.
  3. pmc Intercellular adhesion molecule-1-dependent neutrophil adhesion to endothelial cells induces caveolae-mediated pulmonary vascular hyperpermeability
    Guochang Hu
    Department of Pharmacology, University of Illinois College of Medicine, 835 S Wolcott Ave, Chicago, IL 60612, USA
    Circ Res 102:e120-31. 2008
    ..To address the role of PMN interaction with endothelial cells, we used an intercellular adhesion molecule (ICAM)-1 blocking monoclonal antibody...
  4. doi Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats
    Chin Yi Cheng
    Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
    Brain Res 1209:136-50. 2008
    ..have shown that ferulic acid (4-hydroxy-3-methoxycinnamic acid, FA) inhibits intercellular adhesion molecule-1 (ICAM-1) expression in the ischemic striatum after 2 h of reperfusion in a transient middle cerebral artery occlusion ..
  5. doi Vaspin prevents TNF-α-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-κB and PKCθ activation in cultured rat vascular smooth muscle cells
    Sukanya Phalitakul
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Pharmacol Res 64:493-500. 2011
    ..Vaspin significantly inhibited the protein expression of intracellular adhesion molecule (ICAM)-1 and the phosphorylation of NF-κB and protein kinase C (PKC)θ induced by TNF-α...
  6. pmc PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells
    Jean Pierre Couty
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Neurochem 103:793-801. 2007
    ..by the engagement of adhesion molecules expressed on brain endothelial cells, we previously documented the role of ICAM-1 in activation of the tyrosine phosphorylation of several actin-binding proteins and subsequent rearrangements of ..
  7. pmc Diminished ICAM-1 expression and impaired pulmonary clearance of nontypeable Haemophilus influenzae in a mouse model of chronic obstructive pulmonary disease/emphysema
    Bing Pang
    Departments of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Infect Immun 76:4959-67. 2008
    ..revealed minimal differences in localized lung inflammation between the two groups, lower levels of intercellular adhesion molecule 1 (ICAM-1) were observed for the airway epithelial surface of elastase-treated mice than for those of ..
  8. ncbi K469E polymorphism of the intracellular adhesion molecule 1 gene is associated with proliferative diabetic retinopathy in Caucasians with type 2 diabetes
    Mojca Globocnik Petrovic
    Eye Clinic, University Medical Centre Ljubljana, Slovenia
    Clin Exp Ophthalmol 36:468-72. 2008
    ..molecules (CAMs)The objective of this study was to investigate the association between the polymorphisms of the ICAM-1 gene (K469E, G241A) and the development of PDR among patients with type 2 diabetes in the Slovenian population (..
  9. doi Involvement of the peripheral sensory and sympathetic nervous system in the vascular endothelial expression of ICAM-1 and the recruitment of opioid-containing immune cells to inhibit inflammatory pain
    Shaaban A Mousa
    Department of Anaesthesiology and Intensive Care Medicine, Charite University Berlin, Campus Virchow Klinikum and Campus Charite Mitte, Berlin, Germany
    Brain Behav Immun 24:1310-23. 2010
    ..prerequisite for the recruitment of such leukocytes is the expression of intracellular adhesion molecule-1 (ICAM-1) in blood vessels of inflamed tissue...
  10. ncbi Intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 at the early stages of atherosclerosis in a rat model
    Lampros Fotis
    Laboratory for Experimental Surgery and Surgical Research N S Christeas, Athens University Medical School, Athens, Greece
    In Vivo 26:243-50. 2012
    ..endothelial adhesion molecules, vascular cell adhesion molecule (VCAM-1) and intercellular cell adhesion molecule (ICAM-1), participate in leukocyte adhesion to the endothelium and play an important role in all stages of ..
  11. pmc Increased expression of ICAM-1, VCAM-1, MCP-1, and MIP-1 alpha by spinal perivascular macrophages during experimental allergic encephalomyelitis in rats
    Nils Hofmann
    Institut für Anatomie der Universität zu Köln, Germany
    BMC Immunol 3:11. 2002
    ..Apart from the poor spatial and optical resolution, no differentiation between the resident SPM (mabs ED1+, ED2+) and the just recruited monocytes/macrophages (mab ED1+) was possible...
  12. ncbi Concomitant upregulation of nuclear factor-kB activity, proinflammatory cytokines and ICAM-1 in the injured brain after cortical contusion trauma in a rat model
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, China
    Neurol India 53:312-7. 2005
    Nuclear factor kappa B (NF-kB), proinflammatory cytokines and intercellular adhesion molecule 1 (ICAM-1) are frequently upregulated in the injured brain after traumatic brain injury (TBI)...
  13. pmc ICAM-1-mediated endothelial nitric oxide synthase activation via calcium and AMP-activated protein kinase is required for transendothelial lymphocyte migration
    Roberta Martinelli
    Division of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Mol Biol Cell 20:995-1005. 2009
    ..We have recently shown that paracellular transendothelial lymphocyte migration is controlled by intercellular adhesion molecule 1 (ICAM-1)-mediated vascular endothelial cadherin (VEC) phosphorylation [Turowski et al., J. Cell Sci...
  14. pmc The transcription factor ETS-1 mediates proinflammatory responses and neointima formation in carotid artery endoluminal vascular injury
    Wenguang Feng
    Division of Nephrology and Hypertension, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hypertension 55:1381-8. 2010
    ..This study unveils the role of ETS-1 as a mediator of inflammation and neointima formation in a model of carotid artery balloon injury and may result in the development of novel strategies in the treatment of vascular injury...
  15. doi Pro-healing potential of hemin: an inducer of heme oxygenase-1
    Azad A Ahanger
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar UP, PIN 243 122, India
    Eur J Pharmacol 645:165-70. 2010
    ..mRNA expression of cytokines endorsed fast healing as was indicated by inhibition of pro-inflammatory cytokines such as ICAM-1 and TNF-alpha and up-regulation of anti-inflammatory cytokine IL-10.
  16. pmc Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpain
    Amanda R Smolock
    Department of Physiology and the Cardiovascular Research Center, School of Medicine, Temple University, 3500 N Broad St, Philadelphia, PA 19041, USA
    Arterioscler Thromb Vasc Biol 31:289-96. 2011
    ..We tested the hypothesis of a role for the calcium-dependent protease calpain in the endothelial dysfunction induced by hyperglycemic activation of protein kinase C (PKC)...
  17. ncbi Decreased expression of intercellular adhesion molecule-1 (ICAM-1) and urokinase-type plasminogen activator receptor (uPAR) is associated with tumor cell spreading in vivo
    Ana C Donadio
    Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Pabellón Argentina ala I subsuelo, CP 5000, Cordoba, Argentina
    Clin Exp Metastasis 19:437-44. 2002
    ..from a spontaneous rat sarcoma revealed, by flow cytometry, a high frequency of intercellular adhesion molecule-1 (ICAM-1, 70.1 +/- 8.7%) and urokinase-type plaminogen activator receptor (uPAR, 51.2 +/- 5...
  18. ncbi Intercellular adhesion molecule-1 K469E gene polymorphism and Alzheimer's disease
    Roberto Pola
    Laboratory of Vascular Biology and Genetics, Istituto di Patologia Speciale Medica, Universita Cattolica del Sacro Cuore, A Gemelli University Hospital, L go A Gemelli 8, 00168 Rome, Italy
    Neurobiol Aging 24:385-7. 2003
    ..Intercellular adhesion molecule-1 (ICAM-1) is an important mediator of inflammatory response and immune cell activation, is expressed on cerebrovascular ..
  19. ncbi Periovulatory expression of intercellular adhesion molecule-1 in the rat ovary
    Nigel Bonello
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia
    Biol Reprod 71:1384-90. 2004
    ..investigates the ovarian localization and potential gonadotropin regulation of intercellular adhesion molecule-1 (ICAM-1), an important factor in neutrophil and monocyte attachment to endothelium...
  20. ncbi Intercellular adhesion molecule 1 gene polymorphisms in inflammatory bowel disease
    A Papa
    Department of Internal Medicine, Catholic University of Rome Italy
    Eur Rev Med Pharmacol Sci 8:187-91. 2004
    Intercellular adhesion molecule (ICAM)-1 is a single-chain cell surface glycoprotein that plays an important role in the recruitment of leukocytes at sites of inflammation and is up-regulated in intestinal mucosa of inflammatory bowel ..
  21. ncbi Angiotensin II stimulates intercellular adhesion molecule-1 via an AT1 receptor/nuclear factor-kappaB pathway in brain microvascular endothelial cells
    Hui Qing Liu
    Department of Pharmacology, School of Medicine, Shandong University, Jinan, Shandong 250012, PR China
    Life Sci 78:1293-8. 2006
    ..injures brain microvascular endothelial cells (BMEC) partially via stimulating intercellular adhesion molecule-1 (ICAM-1) expression. However, the signaling cascade leading to Ang II-induced ICAM-1 expression in BMEC was unclear...
  22. ncbi ICAM-1 expression and leukocyte behavior in the microcirculation of chronically ischemic rat skeletal muscles
    Stephen I Anderson
    University of Wolverhampton, UK
    Microvasc Res 71:205-11. 2006
    ..known to upregulate leukocyte and endothelial adhesion molecules, but little is known about leukocyte adherence and ICAM-1 expression during chronic ischemia or any likely effect of muscle activity which is recommended in chronic ..
  23. pmc Evaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKinD population
    Jun Ma
    Rolf Luft Center for Diabetes Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    BMC Med Genet 9:47. 2008
    The ICAM-1 gene is a strong positional and biological candidate for susceptibility to the development of T1D and DN...
  24. doi Platelet-derived growth factor BB promotes the migration of bone marrow-derived mesenchymal stem cells towards C6 glioma and up-regulates the expression of intracellular adhesion molecule-1
    Peng Cheng
    Department of Neurosurgery, The First Affiliated Hospital, China Medical University, Nanjingbei Street, No 151, Heping District, Shenyang, Liaoning Province 110001, PR China
    Neurosci Lett 451:52-6. 2009
    ..C6 glioma and evaluate the effect of PDGFBB on the migrating capacity and intercellular adhesion molecule-1 (ICAM-1) expression of BMSCs...
  25. ncbi Involvement of MAPKs in ICAM-1 expression in glomerular endothelial cells in diabetic nephropathy
    Naomi Watanabe
    Departments of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Acta Med Okayama 65:247-57. 2011
    ..the role of mitogen-activated protein kinase (MAPK) pathways for induction of intercellular adhesion molecule-1 (ICAM-1) expression in glomerular endothelial cells under diabetic conditions...
  26. pmc CD18/ICAM-1-dependent oxidative NF-kappaB activation leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells
    I Kurose
    Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    J Clin Invest 99:867-78. 1997
    ..Monoclonal antibodies directed against rat CD18 and ICAM-1, as well as TMB-8, a calcium inhibitor, prevented the calcium mobilization, active oxygen production, and NF-..
  27. ncbi Lactobacillus casei prevents the upregulation of ICAM-1 expression and leukocyte recruitment in experimental colitis
    Sandra Angulo
    Department of Gastroenterology, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain
    Am J Physiol Gastrointest Liver Physiol 291:G1155-62. 2006
    ..cell interactions were characterized in the colonic microcirculation by intravital microscopy, and ICAM-1 and VCAM-1 expression was measured by the radiolabeled antibody technique...
  28. ncbi Renoprotective effect of rosiglitazone through the suppression of renal intercellular adhesion molecule-1 expression in streptozotocin-induced diabetic rats
    Y Qian
    Department of Endocrinology, Anhui Provincial Hospital, Hefei, China
    J Endocrinol Invest 31:1069-74. 2008
    To observe the effect of rosiglitazone on serum intercellular adhesion molecule-1 (SICAM-1) level, urinary excretion of ICAM-1, and renal expression of ICAM-1, and investigate its possible renoprotective mechanisms in diabetic rats.
  29. doi Lower bone mineral density in children with type 1 diabetes is associated with poor glycemic control and higher serum ICAM-1 and urinary isoprostane levels
    Kaire Heilman
    Department of Paediatrics, University of Tartu, 6 Lunini Street, Tartu, 51014, Estonia
    J Bone Miner Metab 27:598-604. 2009
    ..total mineral content adjusted for age and height (BMCadj), and measured plasma intercellular adhesion molecule-1 (ICAM-1), high sensitivity C-reactive protein (hs-CRP), and urinary 8-iso-prostaglandin F(2a) (F(2)-IsoPs)...
  30. doi Association of soluble intercellular adhesion molecule-1 with insulin resistance and metabolic syndrome in Taiwanese
    Lung An Hsu
    Department of Internal Medicine, The First Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Metabolism 58:983-8. 2009
    ..In conclusion, our data revealed that insulin resistance and metabolic syndrome were associated with sICAM-1 levels in Taiwanese. These data provide further evidence of the mechanisms of sICAM-1 as a molecular marker for atherosclerosis...
  31. doi Black tea polyphenol theaflavin suppresses LPS-induced ICAM-1 and VCAM-1 expression via blockage of NF-κB and JNK activation in intestinal epithelial cells
    Young A Song
    Department of Internal Medicine, Chonnam National University Medical School, 8 Hak Dong, Dong Ku, 501 757, Gwangju, Korea
    Inflamm Res 60:493-500. 2011
    ..The aim of this study was to determine the impact of the black tea polyphenol, theaflavin, on the expression of adhesion molecules and activation of lipopolysaccharide (LPS)-induced innate signaling in rat intestinal epithelial (RIE) cells...
  32. ncbi Sequence and expression of rat ICAM-1
    Y Kita
    Molecular Biology Research Laboratory, Tokyo R and D Center, Daiichi Pharmaceutical Co, Japan
    Biochim Biophys Acta 1131:108-10. 1992
    ..molecule-1 (RICAM-1) from a cDNA library constructed from rat Ax cells stimulated with IL-1 beta using the mouse ICAM-1 cDNA as a hybridization probe. The RICAM-1 sequence shows 79.1% homology with mouse ICAM-1 and 55...
  33. ncbi The effect of intestinal ischemia and reperfusion injury on ICAM-1 expression, endothelial barrier function, neutrophil tissue influx, and protease inhibitor levels in rats
    Knut Olanders
    Department of Anesthesiology, Lund University Hospital, Sweden
    Shock 18:86-92. 2002
    ..b>ICAM-1 (intercellular adhesion molecule-1) mediates firm adhesion and transendothelial migration of activated leukocytes ..
  34. ncbi [Concentration of serum soluble forms of ICAM-1 (sVCAM-1) and VCAM-1 (sVCAM-1) in patients with chronic pancreatitis and in patients with pancreatic carcinoma]
    Krystyna Markocka-Maczka
    Katedry i Kliniki Chirurgii Przewodu Pokarmowego i Chirurgii Ogólnej Akademii Medycznej we Wrocławiu
    Wiad Lek 56:147-51. 2003
    ..The selected adhesion molecules concentrations were assessed using immunoassay of solid phase (ELISA)...
  35. ncbi Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia
    Ryon M Bateman
    University of British Columbia Critical Care Research Laboratories, Department of Medicine, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Physiol Heart Circ Physiol 293:H448-56. 2007
    ..05) in the left ventricle. Tissue regions expressing ICAM-1, obtained by using laser-capture microdissection, had increased HIF-1alpha and GLUT1 (P < 0...
  36. ncbi Contribution of soluble intercellular adhesion molecule-1 to the migration of vascular smooth muscle cells
    Hwan Myung Lee
    Department of Medicine, College of Medicine, Konkuk University, 322 Danwol dong, Chungju City, Chungbuk 380 701, South Korea
    Eur J Pharmacol 579:260-8. 2008
    Soluble intercellular adhesion molecule-1 (sICAM-1), a circulating form of ICAM-1, has been known to be involved in the development of vascular diseases that are associated with vascular smooth muscle cell migration, such as hypertension ..
  37. doi The effect of simvastatin on the serum monocyte chemoattractant protein-1 and intracellular adhesion molecule-1 levels in diabetic rats
    Yang Lin
    Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, 230001, China
    J Diabetes Complications 23:214-8. 2009
    This study aimed to observe the effect of simvastatin on the serum monocyte chemoattractant protein-1 (MCP-1) and intracellular adhesion molecule-1 (ICAM-1) levels and to probe its protective mechanisms on macroangiopathy in diabetic rats.
  38. doi Insulin regulates cytokines and intercellular adhesion molecule-1 gene expression through nuclear factor-kappaB activation in LPS-induced acute lung injury in rats
    Joilson O Martins
    Research Division, Heart Institute InCor, LIM 11, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Shock 31:404-9. 2009
    ..The goal of this study was to investigate whether insulin regulates transcription of cytokines and intercellular adhesion molecule 1 (ICAM-1) via nuclear factor-kappaB (NF-kappaB) signaling pathway in Escherichia coli LPS-induced ..
  39. doi Effects of Salvia miltiorrhiza on intercellular adhesion molecule 1 protein expression in the lungs of rats with severe acute pancreatitis or obstructive jaundice
    Zhang Xiping
    Department of General Surgery, Hangzhou First People s Hospital, Hangzhou, Zhejiang Province, China
    Pancreas 38:309-17. 2009
    The objective of the study was to observe the effects of Salvia miltiorrhiza on intercellular adhesion molecule 1 (ICAM-1) protein expression in the lungs of rats with severe acute pancreatitis (SAP) or obstructive jaundice (OJ).
  40. pmc Activation of epithelial and myoepithelial cells in the salivary glands of patients with Sjögren's syndrome: high expression of intercellular adhesion molecule-1 (ICAM.1) in biopsy specimens and cultured cells
    E K Kapsogeorgou
    Laboratory of Immunology, Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece
    Clin Exp Immunol 124:126-33. 2001
    b>ICAM.1 (CD54) is a surface protein expressed on epithelial and other nonhematopoietic cells upon activation and is known to play an important role in the stimulation of T cells by the provision of cellular adhesion and costimulatory ..
  41. pmc Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo
    Antonia M Joussen
    Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Am J Pathol 160:501-9. 2002
    ..Previous work has shown that intercellular adhesion molecule-1 (ICAM-1) and CD18 are required for these processes...
  42. ncbi Activated rat pancreatic stellate cells express intercellular adhesion molecule-1 (ICAM-1) in vitro
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 25:78-85. 2002
    ..Activated pancreatic stellate cells (PSCs) have recently been implicated in the pathogenesis of pancreatic fibrosis...
  43. pmc Genetic influences of the intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in development of Type 1 diabetes and diabetic nephropathy
    J Ma
    Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden
    Diabet Med 23:1093-9. 2006
    The intercellular adhesion molecule-1 (ICAM-1) gene is located on chromosome 19p13, which is linked to Type 1 diabetes (T1D). ICAM-1 expression is related to development of T1D and diabetic nephropathy...
  44. ncbi Novel regulatory mechanism of cardiomyocyte contractility involving ICAM-1 and the cytoskeleton
    Ehsan Y Davani
    Critical Care Research Laboratories, St Paul s Hospital, University of British Columbia, Vancouver, Canada V6Z 1Y6
    Am J Physiol Heart Circ Physiol 287:H1013-22. 2004
    b>ICAM-1 mediates interaction of cardiomyocytes with the extracellular matrix and leukocytes and may play a role in altering contractility...
  45. ncbi Intercellular adhesion molecule-1 and blood-spinal cord barrier disruption in central nervous system radiation injury
    Robert A Nordal
    Department of Radiation Oncology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Neuropathol Exp Neurol 63:474-83. 2004
    ..Increased expression of intercellular adhesion molecule-1 (ICAM-1) accompanies and is believed to be important in BBB disruption in other CNS injuries...
  46. pmc Up-regulation of intestinal nuclear factor kappa B and intercellular adhesion molecule-1 following traumatic brain injury in rats
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 11:1149-54. 2005
    ..to critical illnesses, but it is not known if and how NF-kappaB is activated and intercellular adhesion molecule-1 (ICAM-1) expressed in the gut following traumatic brain injury (TBI)...
  47. pmc Effect of nuclear factor kappa B on intercellular adhesion molecule-1 expression and neutrophil infiltration in lung injury induced by intestinal ischemia/reperfusion in rats
    Xiao Feng Tian
    Department of General Surgery, Second Affiliated Hospital, Dalian Medical University, Dalian 116027, Liaoning Province, China
    World J Gastroenterol 12:388-92. 2006
    ..the role of nuclear factor kappa B (NF-kappaB) in the pathogenesis of lung injury induced by intestinal ischemia/reperfusion (I/R), and its effect on intercellular adhesion molecule-1 (ICAM-1) expression and neutrophil infiltration.
  48. doi Taurine rescues vascular endothelial dysfunction in streptozocin-induced diabetic rats: correlated with downregulation of LOX-1 and ICAM-1 expression on aortas
    Li Jun Wang
    Department of Pediatrics, Provincial Hospital affiliated to Shandong University, Jinan 250021, China
    Eur J Pharmacol 597:75-80. 2008
    ..oxLDL and soluble intercellular adhesion molecule (sICAM-l) levels, LOX-1 and intercellular adhesion molecule (ICAM-1) expression on aortas were determined respectively...
  49. pmc Regional gene expression of LOX-1, VCAM-1, and ICAM-1 in aorta of HIV-1 transgenic rats
    Anne Mette Fisker Hag
    Cluster for Molecular Imaging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e8170. 2009
    ..As clinical studies are complicated by a multiplicity of risk-factors and a low incidence of hard endpoints, studies in animal models could be attractive alternatives...
  50. ncbi Amelioration of chronic and spontaneous intestinal inflammation with an antisense oligonucleotide (ISIS 9125) to intracellular adhesion molecule-1 in the HLA-B27/beta2 microglobulin transgenic rat model
    Mary Beth Bowen-Yacyshyn
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
    J Pharmacol Exp Ther 302:908-17. 2002
    ..Intracellular adhesion molecule-1 (ICAM-1 or CD54) is constitutively expressed on endothelial cells and is up-regulated during acute and chronic ..
  51. pmc Adhesion molecule expression in psoriatic skin lesions and the influence of cyclosporin A
    C Horrocks
    Department of Pathology, University of Aberdeen, Scotland, UK
    Clin Exp Immunol 84:157-62. 1991
    ..In uninvolved skin, weak expression of CD54 (intercellular adhesion molecule 1, ICAM-1) was noted on vascular endothelium...
  52. ncbi Monoclonal antibodies against CD54 (ICAM-1) and CD11a (LFA-1) prevent and inhibit endotoxin-induced uveitis
    S M Whitcup
    National Eye Institute, National Institutes of Health, Bethesda, MD
    Exp Eye Res 60:597-601. 1995
    We studied the effect of monoclonal antibodies (mAbs) against CD54 (intercellular adhesion molecule-1; ICAM-1) and CD11a (lymphocyte function-associated antigen-1; LFA-1) on the prevention and treatment of endotoxin-induced uveitis (EIU)...
  53. ncbi Expression on leukemic cells and serum circulating levels of intercellular adhesion molecule-1 (ICAM-1) in B-cell chronic lymphocytic leukemia: implications for prognosis
    S Molica
    Divisione di Ematologia, Ospedale Regionale A Pugliese, Catanzaro, Italy
    Leuk Res 19:573-80. 1995
    Expression of intercellular adhesion molecule-1 (ICAM-1) has been correlated clinical and laboratory characteristics of 62 patients with untreated CD5+ chronic lymphocytic leukemia (CLL)...
  54. ncbi Monoclonal antibodies against ICAM-1 (CD54) and LFA-1 (CD11a/CD18) inhibit experimental autoimmune uveitis
    S M Whitcup
    Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892
    Clin Immunol Immunopathol 67:143-50. 1993
    ..We studied the expression of two cell adhesion molecules: intercellular adhesion molecule-1 (ICAM-1, CD54) and lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18) in mice with experimental autoimmune ..
  55. ncbi The critical role of intercellular adhesion molecule-1 in Masugi nephritis in rats
    J Wada
    Third Department of Internal Medicine, Okayama University Medical School, Japan
    Nephron 73:264-72. 1996
    Intercellular adhesion molecule-1 (ICAM-1, CD54), an adhesion molecule of the immunoglobulin superfamily, is an endothelial cell surface ligand for such leukocyte integrins as lymphocyte-function-associated molecule 1 (LFA-1, CD11a/CD18), ..
  56. ncbi Glutathione depletion prevents lipopolysaccharide-induced local skin inflammation
    J J Jones
    Department of Surgery, Toronto Hospital, Ontario
    Arch Surg 132:1165-9; discussion 1170. 1997
    We have previously shown that the thiol-oxidizing agent diethyl maleate prevents lipopolysaccharide (LPS)-induced up-regulation of endothelial cell intercellular adhesion molecule-1 (ICAM-1) in vitro.
  57. ncbi Soluble E-selectin, ICAM-1 and VCAM-1 levels in systemic and coronary circulation in patients with variant angina
    K Miwa
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan
    Cardiovasc Res 36:37-44. 1997
    ..whether the plasma levels of soluble adhesion molecules including E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are elevated in patients with variant angina and whether they are ..
  58. pmc Vitreous intercellular adhesion molecule 1 in uveitis complicated by retinal detachment
    L Webster
    Department of Ophthalmology, Rayne Institute, UMDS, St Thomas s Hospital, London
    Br J Ophthalmol 82:438-43. 1998
    The vitreous levels of soluble intercellular adhesion molecule 1 (sICAM-1) were investigated in uveitic eyes undergoing vitrectomy for retinal detachment (RD) or other complications, and the presence of this molecule was related to ..
  59. ncbi Intercellular adhesion molecule-1 gene polymorphisms in Behçet's disease
    D H Verity
    Guy s and St Thomas Hospitals, London, UK
    Eur J Immunogenet 27:73-6. 2000
    Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms have been implicated in the susceptibility to inflammatory diseases, including multiple sclerosis and inflammatory bowel disease...
  60. ncbi Elevated soluble intercellular adhesion molecule-1 levels in obesity: relationship to insulin resistance and tumor necrosis factor-alpha system activity
    Marek Straczkowski
    Departments of Endocrinology and Pediatric Neurology, Medical Academy, Bialystok, Poland and the Max Planck Institute for Experimental Medicine, Goettingen, Germany
    Metabolism 51:75-8. 2002
    Intercellular adhesion molecule-1 (ICAM-1) is 1 of the possible factors linking obesity and diabetes with cardiovascular disease, however, the mechanism of the increase in ICAM-1 concentration in obesity remains unclear...
  61. ncbi Opioid control of inflammatory pain regulated by intercellular adhesion molecule-1
    Halina Machelska
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Klinikum Benjamin Franklin, Freie Universitat Berlin, D 12200 Berlin, Germany
    J Neurosci 22:5588-96. 2002
    ..Intercellular adhesion molecule-1 [ICAM-1 (or CD54)] is expressed by endothelium and mediates adhesion and extravasation of leukocytes...
  62. ncbi Ezrin and moesin co-localise with ICAM-1 in brain endothelial cells but are not directly associated
    Ignacio A Romero
    Endothelial and Epithelial Cell Biology Unit, Department of Cell Biology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Brain Res Mol Brain Res 105:47-59. 2002
    The precise mechanism by which ICAM-1 transduces signals from adherent lymphocytes remains elusive...
  63. ncbi The upregulation of ICAM-1 and P-selectin requires high blood pressure but not circulating renin-angiotensin system in vivo
    Huan Wang
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    J Hypertens 22:1323-32. 2004
    ..To investigate the separate contributions of blood pressure and the circulating renin-angiotensin system to the upregulation of vascular endothelial adhesion molecules in vivo...
  64. ncbi Inhibition of tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression in diabetic rats: role of insulin
    E A Anjos-Valotta
    Research Division, Institute of Heart InCor, LIM 11, University of Sao Paulo Medical School, Av Dr Eneas de Carvalho Aguiar 44, 05403 000 Sao Paulo, SP, Brazil
    Inflamm Res 55:16-22. 2006
    The effects of insulin on intercellular adhesion molecule (ICAM)-1-mediated leukocyte adhesion and migration were investigated.
  65. ncbi Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium
    Yaojiong Wu
    Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Circ Res 99:315-22. 2006
    ..Among them, CD18 and its ligand ICAM-1 are particularly intriguing because CD18 and its heterodimer binding chains CD11a and CD11b were correspondingly ..
  66. pmc Expression and significance of ICAM-1 and its counter receptors LFA-1 and Mac-1 in experimental acute pancreatitis of rats
    Wei Sun
    Department of Pediatric Surgery, Kagawa Medical University, Japan
    World J Gastroenterol 12:5005-9. 2006
    To investigate the role of intercellular adhesion molecule-1 (ICAM-1) and its counter receptors LFA-1 and Mac-1 in acute pancreatitis (AP).
  67. ncbi Intercellular adhesion molecule 1 gene polymorphisms do not contribute to Graves' disease in Chinese patients
    Shu Wang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, PR China
    Endocrine 31:114-8. 2007
    In order to study the association of G241R polymorphism of ICAM-1 gene with an earlier onset of Graves' disease (GD) and the susceptibility of K469E polymorphism to Graves' ophthalmopathy (GO) in Chinese population.
  68. doi Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure
    Ping Chia Li
    Dept of Occupational Therapy, I Shou Univ, No 8 E Da Road, Jiau Shu Tsuen, Yan Chau Shiang, Kaohsiung County 824, Tainan City, Republic of China Taiwan
    Am J Physiol Lung Cell Mol Physiol 294:L912-20. 2008
    ..SP) acts via neurokinin (NK)-1 and NK-2 receptors to stimulate neurogenic inflammation (indicated by formation of ICAM-1 expression and oxidative stress) following oil smoke exposure (OSE) in rats; and 2) determine if pretreatment ..
  69. pmc Fructose induces the inflammatory molecule ICAM-1 in endothelial cells
    Olena Glushakova
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 19:1712-20. 2008
    ..endothelial inflammatory processes by upregulating the inflammatory molecule intercellular adhesion molecule-1 (ICAM-1)...
  70. ncbi [Levels of soluble adhesion molecules among normal and hypertensive type 2 diabetic patients]
    Alberto Francisco Rubio-Guerra
    Clínica de Hipertensión Arterial, Hospital General de Ticoman, Secretaria de Salud, Mexico D F, Mexico
    Gac Med Mex 144:11-4. 2008
    ..The aim of this study was to assess soluble adhesion molecule levels among normotensive and hypertensive diabetic patients...
  71. doi Endothelial/lymphocyte activation leads to prominent CD4+ T cell infiltration in the gastric mucosa of patients with systemic sclerosis
    Mirko Manetti
    University of Florence, Florence, Italy
    Arthritis Rheum 58:2866-73. 2008
    ..The aim of the present study was to investigate whether immune and/or microvascular abnormalities may account for tissue damage in gastric wall specimens obtained from patients with SSc...
  72. doi Inflammatory markers in exhaled breath condensate following lung resection for bronchial carcinoma
    Wolfgang Jungraithmayr
    Department of Thoracic Surgery, University Hospital Freiburg, Freiburg, Germany
    Respirology 13:1022-7. 2008
    ..This study investigated the pattern of serum inflammatory markers and exhaled breath condensate (EBC) in patients undergoing major lung resection due to bronchial carcinoma compared with minimally invasive thoracic surgery...
  73. doi Immunohistochemical analysis of cellular adhesion molecules (ICAM-1, VCAM-1) and VEGF in fibrovascular membranes of patients with proliferative diabetic retinopathy: preliminary study
    T Khalfaoui
    Service d Ophtalmologie, Hopital Charles Nicolle, Boulevard du 9 Avril, Bab Souika, 1006 Tunis, Tunisia
    Pathol Biol (Paris) 57:513-7. 2009
    ..To this end, we analyzed the simultaneous expression of ICAM-1, VCAM-1 and VEGF within tissues of diabetic fibrovascular membranes.
  74. ncbi [Changes of ICAM-1 mRNA expression in rats' skin and muscle after contusion]
    Jun Hong Sun
    School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China
    Fa Yi Xue Za Zhi 24:407-10. 2008
    To investigate the expression of intercellular adhesion molecule-1 (ICAM-1) mRNA in contused skin and muscle of rats and the relationship between the ICAM-1 expression and the wound age.
  75. pmc The effects of aerosolized STAT1 antisense oligodeoxynucleotides on rat pulmonary fibrosis
    Wen Jun Wang
    The Department of Respiratory Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China
    Cell Mol Immunol 6:51-9. 2009
    ..activator of transcription-1 (STAT1) antisense oligodeoxynucleotide (ASON) inhibited the expression of STAT1 and ICAM-1 mRNA and protein in alveolar macrophages (AMs) and decreased the concentrations of TGF-beta, PDGF and TNF-alpha ..
  76. doi NK cells from tuberculous pleurisy express high ICAM-1 levels and exert stimulatory effect on local T cells
    Pablo Schierloh
    Departamento de Inmunologia, Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, Argentina
    Eur J Immunol 39:2450-8. 2009
    ..We found that endogenously activated pleural fluid-derived NK cells express high ICAM-1 levels and induce T-cell activation ex vivo through ICAM-1...
  77. ncbi [Effects of curcumin on the expression of nuclear factor-kappaB and intercellular adhesion molecular 1 in rats with cerebral ischemia-reperfusion injury]
    Rong Zhuang
    Department of Intensive Care Unit, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:1153-5. 2009
    To investigate the effects of curcumin on the expression of nuclear factor-kappaB (NF-kappaB) and intercellular adhesion molecular 1 (ICAM-1) in rats with cerebral ischemia-reperfusion (IR) injury.
  78. doi Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling
    Yan Sun
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Lab Invest 90:68-82. 2010
    ..collagen remodeling and pulmonary vascular endothelial cell nuclear factor-kappaB (NF-kappaB), and intercellular adhesion molecule 1 (ICAM-1) expressions...
  79. doi Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo
    Tomoaki Hattori
    Department of Ophthalmology and Visual Sciences, Nagoya City University Graduate School of Medicine, 1 Kawasumi, Nagoya, Japan
    Curr Eye Res 35:146-54. 2010
    ..In this study, we investigated the effect of fidarestat on leukocyte-endothelial cell interactions in an in vivo experimental model for diabetic retina...
  80. doi Increased cytokines, chemokines and soluble adhesion molecules in exhaled breath condensate of asthmatic children
    C M H H T Robroeks
    Department of Paediatric Pulmonology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Clin Exp Allergy 40:77-84. 2010
    ..However, the use of a glass condenser system combined with a sensitive analytical technique may increase the possibility to assess these biomarkers in EBC in a reliable way...
  81. doi RILLKKMPSV influences the vasculature, neurons and glia, and (pro)renin receptor expression in the retina
    Jennifer L Wilkinson-Berka
    Department of Immunology, Monash University, Melbourne, Victoria, Australia
    Hypertension 55:1454-60. 2010
    ....
  82. pmc Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain
    Won Hee Lee
    School of Biomedical Engineering and Sciences, Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University Virginia Tech, Blacksburg, VA 24061, USA
    Neurosci Lett 476:89-93. 2010
    ..factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, monocyte chemoattractant protein-1 (MCP-1), and matrix ..
  83. pmc Elevated mineralocorticoid receptor activity in aged rat vascular smooth muscle cells promotes a proinflammatory phenotype via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase and epidermal growth factor receptor-dependent pathwa
    Alexander W Krug
    National Institutes of Health, National Institute on Aging, Laboratory of Cardiovascular Science, Baltimore, MD 21224, USA
    Hypertension 55:1476-83. 2010
    ..protein kinase inhibition prevent age-associated increases of transforming growth factor-beta, intercellular adhesion molecule 1, and procollagen 1...
  84. doi G/R 241 polymorphism of intercellular adhesion molecule 1 (ICAM-1) is associated with Fuchs uveitis
    Luca Cimino
    Ocular Immunology Unit, Arcispedale S Maria Nuova REggion emilia, Italy
    Invest Ophthalmol Vis Sci 51:4447-50. 2010
    To investigate potential associations of the ICAM-1 gene polymorphisms and Fuchs uveitis in a cohort of Italian patients.
  85. doi Pentoxifylline inhibits intercellular adhesion molecule-1 (ICAM-1) and lung injury in experimental phosgene-exposure rats
    Xiao di Zhang
    Department of Toxicology, The Fourth Military Medical University, Xi an, PR China
    Inhal Toxicol 22:889-95. 2010
    ..Inflammatory cells play an important role in the ALI caused by phosgene. Intercellular adhesion molecule-1 (ICAM-1) is a critical factor for inflammatory organ injury...
  86. doi Glutamine treatment attenuates the development of ischaemia/reperfusion injury of the gut
    Stefania Mondello
    Department of Internal Medicine, University of Messina, Italy
    Eur J Pharmacol 643:304-15. 2010
    ..of the reperfused intestine (MPO activity); (3) NF-kappaB activation and cytokines production; (4) expression of ICAM-1 and P-selectin during reperfusion; (5) nitrotyrosine and poly-ADP-ribose formation; (6) pro-inflammatory cytokine ..
  87. ncbi Effects of long-term ethanol consumption on adhesion molecules in liver
    Subir Kumar Das
    Department of Biochemistry, Agartala Govt Medical College, Kunjaban P O, Agartala 799 006, India
    Indian J Exp Biol 48:394-401. 2010
    ..The results suggest that the adhesion molecules may be associated with the initiation of hepatic injury during alcohol intoxication...
  88. doi Protective effect of carnosol on lung injury induced by intestinal ischemia/reperfusion
    Xiao Feng Tian
    Department of General Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian, PR China
    Surg Today 40:858-65. 2010
    ..The purpose of this study was to investigate the preconditioning effects of carnosol on lung injury induced by intestinal ischemia/reperfusion (II/R)...
  89. doi Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion
    Yufeng Zhang
    Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China
    Int J Cardiol 148:91-5. 2011
    ..To study the possible anti-inflammatory effect of hydrogen-rich saline (H(2) saline) on rat hearts with regional myocardial ischemia and reperfusion (I/R)...
  90. doi Platelet activating factor induces blood brain barrier permeability alteration in vitro
    Weirong Fang
    Department of Physiology, China Pharmaceutical University, Nanjing 210009, PR China
    J Neuroimmunol 230:42-7. 2011
    ..Intercellular adhesion molecule-1 (ICAM-1) mRNA and protein expression levels in RBMECs were assayed by RT-PCR and flow cytometry respectively...
  91. pmc Curcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-κB activation
    Wei Bing Song
    Department of Gerontology, General Hospital of Guangzhou Military Command of People s Liberation Army, Guangzhou, China
    PLoS ONE 5:e12969. 2010
    ..We studied curcumin's protective effect on IMB and examined its mechanism by using methotrexate (MTX) induced rat enteritis model and lipopolysaccharide (LPS) treated cell death model...
  92. doi Amphetamine modulates cellular recruitment and airway reactivity in a rat model of allergic lung inflammation
    Ana Paula Ligeiro de Oliveira
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Toxicol Lett 200:117-23. 2011
    ..the OVA challenge reduced cell recruitment into the lung, the vascular permeability and the cellular expression of ICAM-1 and Mac-1...
  93. doi Effects of intercellular adhesion molecule-1 on renal damage in spontaneously hypertensive rats
    Ding Wu Zhang
    Department of Nephrology, The Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
    Ren Fail 34:915-20. 2012
    Intercellular adhesion molecule-1 (ICAM-1) plays an important role in the inflammatory process and immune response...
  94. pmc Involvement of nuclear factor kappa B in high-fat diet-related pancreatic fibrosis in rats
    Ming Xian Yan
    Department of Gastroenterology, Shandong Qianfoshan Hospital, Shandong University School of Medicine, Shandong, China
    Gut Liver 6:381-7. 2012
    ..High-fat diets contribute to pancreatic fibrogenesis, but the pathogenesis remains unclear. This study investigated the role of nuclear factor kappa B (NF-κB) in high-fat diet-induced pancreatic fibrosis in rats...
  95. pmc Intercellular adhesion molecule-1 inhibits osteogenic differentiation of mesenchymal stem cells and impairs bio-scaffold-mediated bone regeneration in vivo
    Fen Fen Xu
    1 Department of Cell Biology, Institute of Basic Medical Sciences, Beijing, People s Republic of China
    Tissue Eng Part A 20:2768-82. 2014
    ..interleukin-1α, interleukin-1β, and tumor necrosis factor α, stimulated intercellular adhesion molecule-1(ICAM-1) expression and impaired osteogenic differentiation of MSCs...
  96. doi Microvascular abnormalities in adjuvant-induced arthritis: relationship to macrovascular endothelial function and markers of endothelial activation
    Perle Totoson
    EA 4267, FHU INCREASE, Besancon, France
    Arthritis Rheumatol 67:1203-13. 2015
    ..To determine the time course of microvascular abnormalities and the link with macrovascular endothelial function and circulating markers of endothelial activation in adjuvant-induced arthritis (AIA) in rats...
  97. pmc Platelet-derived Wnt antagonist Dickkopf-1 is implicated in ICAM-1/VCAM-1-mediated neutrophilic acute lung inflammation
    Yujie Guo
    Lundberg Kienlen Lung Biology and Toxicology Laboratory, Department of Physiological Sciences and Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, OK
    Blood 126:2220-9. 2015
    ..Activation of Wnt/β-catenin signaling in AECs attenuated intercellular adhesion molecule 1 (ICAM-1)/vascular cell adhesion molecule 1 (VCAM-1)-mediated adhesion of both macrophages and ..
  98. doi Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression
    L Meng
    Department of Anesthesiology, Wuhan Union Hospital of China, Wuhan, China
    Genet Mol Res 15:. 2016
    ..Serum intercellular adhesion molecule (ICAM)-1 and macrophage inflammatory protein 2 (MIP-2) levels were detected and ICAM-1 and MIP-2 mRNA expression in lung ..
  99. ncbi MiR-146a Regulates Inflammatory Infiltration by Macrophages in Polymyositis/Dermatomyositis by Targeting TRAF6 and Affecting IL-17/ICAM-1 Pathway
    Yuanqin Yin
    Cancer Institute, First Affiliated Hospital, China Medical University, Shenyang, China
    Cell Physiol Biochem 40:486-498. 2016
    ..of macrophages in polymyositis/dermatomyositis (PM/DM) through targeting TNF receptor associated factor 6 (TRAF6), which may further down-regulate the Interleukin-17 (IL-17)/Intercellular Adhesion Molecule 1 (ICAM-1) pathway.
  100. ncbi Upregulated Expression of Rat Heart Intercellular Adhesion Molecule-1 in Angiotensin II- but Not Phenylephrine- Induced Hypertension
    Arash Kiarash
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich
    Hypertension 37:58-65. 2001
    Intercellular adhesion molecule-1 (ICAM-1), part of an immunoglobulin-like superfamily of adhesion molecules, is involved in several cardiovascular diseases...

Research Grants9

  1. The Effects of Resveratrol on Presbyacusis
    Michael Seidman; Fiscal Year: 2004
    ..Furthermore, these data will provide novel strategies to impart greater wellness in the elderly population and perhaps have a positive effect on health care expenses. ..
  2. Baltimore VIRAHEP-C Clinical Center
    Charles Howell; Fiscal Year: 2005
    ..These studies may provide important new insights into the pathogenesis of HCV and lead to novel therapies for chronic HCV. ..
  3. DETERMINANTS OF CORONARY DISEASE IN HIGH RISK FAMILIES
    Lewis Becker; Fiscal Year: 2001
    ..This study will provide important insights into the phenotypic and genetic determinants of clinical and occult CHD in families with premature CHD. ..
  4. Alveolar Epithelium in Acute Lung Injury
    Lorraine Ware; Fiscal Year: 2005
    ..Combined with a compelling research project, the training will -provide the skills necessary for a successful career in biomedical research. ..
  5. Murine CMV Pneumonitis in Allogeneic BMT
    Oliver Oakley; Fiscal Year: 2005
    ..This research will also provide the opportunity for students to participate actively in the solution to an important clinical problem. ..
  6. Coronary Disease Detection by Thalluim SPECT and Fast CT
    Lewis Becker; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  7. Biomarker Profiles in the Diagnosis/Prognosis of ARDS
    Lorraine Ware; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  8. Genotypic Determinants of Aspirin Response in High Risk Families
    Lewis Becker; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. Genome-Wide Association of Platelet Phenotypes
    Lewis Becker; Fiscal Year: 2009
    ..This study represents the first genome -wide SNP association study of comprehensive platelet function and should lead to novel tailored anti-platelet therapy for the prevention of vascular thromboses. (End of Abstract) ..