Hsd3b1

Summary

Gene Symbol: Hsd3b1
Description: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Alias: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1, 3 beta-hydroxysteroid dehydrogenase 1, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I, 3-beta-HSD I, 3betaHSD, hydroxysteroid dehydrogenase-1, delta<5>-3-beta
Species: rat

Top Publications

  1. ncbi Ontogenesis of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in the rat adrenal as revealed by immunocytochemistry and in situ hybridization
    E Dupont
    MRC Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Endocrinology 129:2687-92. 1991
  2. ncbi Ontogenesis of 3 beta-hydroxysteroid dehydrogenase delta 5-delta 4 isomerase in the rat ovary as studied by immunocytochemistry and in situ hybridization
    C Juneau
    MRC Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Biol Reprod 48:226-34. 1993
  3. doi Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats
    Perumal Elumalai
    Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, 600 113, India
    Reprod Toxicol 27:41-5. 2009
  4. ncbi Evaluation of single intratesticular injection of calcium chloride for nonsurgical sterilization in adult albino rats
    Kuladip Jana
    Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Calcutta 700 037, West Bengal, India
    Contraception 73:289-300. 2006
  5. ncbi Hypothyroidism prolongs corpus luteum function in the pregnant rat
    María Belén Hapon
    Laboratorio de Reproduccion y Lactancia, IMBECU CONICET, Mendoza, Argentina
    Reproduction 133:197-205. 2007
  6. ncbi Strontium fructose 1,6-diphosphate rescues adenine-induced male hypogonadism and upregulates the testicular endothelin-1 system
    Yu Feng
    Research Division of Pharmacology, China Pharmaceutical University, Nanjing, China
    Clin Exp Pharmacol Physiol 34:1131-7. 2007
  7. doi The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue
    Scott M MacKenzie
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK
    J Endocrinol 196:123-30. 2008
  8. ncbi [Ginkgo biloba extract enhances testosterone synthesis of Leydig cells in type 2 diabetic rats]
    Xiao Ye Wu
    Department of Pathology, 1st Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang 325000, China
    Zhonghua Nan Ke Xue 14:371-6. 2008
  9. doi The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis
    A Adamsson
    Department of Physiology, University of Turku, Turku, Finland
    Int J Androl 32:575-85. 2009
  10. doi Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis
    Leon J S Brokken
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Endocrinology 150:445-51. 2009

Scientific Experts

  • Roland Rosmond
  • María Belén Hapon
  • A K Chandra
  • P J O'Shaughnessy
  • Kuladip Jana
  • Ann E Drummond
  • M Szołtys
  • Shinji Tsukahara
  • A Adamsson
  • Xiao Ye Wu
  • A Slominski
  • N Cherradi
  • Christine Chabrolle
  • Vikas Kumar
  • Rosalba Escamilla-Hernandez
  • Ren Shan Ge
  • Ye Chen Xiao
  • Partha Roy
  • María Guillermina Bilbao
  • Tatjana S Kostic
  • Anna Bolivar Victor-Costa
  • Tetsuya Kimoto
  • Eri Nakamura
  • Dianne O Hardy
  • L Pinilla
  • Guo Xin Hu
  • Perumal Elumalai
  • Graciela E Hurtado de Catalfo
  • Leon J S Brokken
  • Francisco M Zurvarra
  • Lynda Little-Ihrig
  • Yun Ju Chen
  • Prabhu Venkataraman
  • Laxmipriya P Nampoothiri
  • Jagadeesan Arunakaran
  • Anthony J Zeleznik
  • S Vaithinathan
  • Ping Zhao
  • Scott M MacKenzie
  • C Parthasarathy
  • Mark J McVey
  • Sivasankaran Rajeswary
  • Yu Feng
  • Palaniappan Murugesan
  • Zhimin Shi
  • D K Gautam
  • S S Swathy
  • K K Soma
  • Hui Ping Wang
  • Ethel Codner
  • S Chaudhuri-Sengupta
  • Norio Hashimoto
  • María Paula Di Yorio
  • Alicia Graciela Faletti
  • V L Nelson
  • Natasa J Stojkov
  • Silvana A Andric
  • Marija M Janjic
  • Maja M Bjelic
  • Aleksandar I Mihajlovic
  • Simone Miranda Carozzi Bandeira
  • Xiao Kun Li
  • Ryutaro Yamanaka
  • Shimpei Higo
  • Naoko Tsukamoto
  • Hirotaka Ishii
  • Suguru Kawato
  • Toshio Ogura
  • Germán Arturo Bohórquez Mahecha
  • Hirofumi Makino
  • Jiro Suzuki
  • Tomoko Miyoshi
  • André Gustavo Oliveira
  • Kenichi Inagaki
  • Ya dong Huang
  • Cleida Aparecida Oliveira
  • Fumio Otsuka
  • Yasushi Hojo
  • Carlos Alberto Marra
  • Bing Bing Chen
  • M Tena-Sempere
  • Maria J T de Alaniz
  • J Ian Mason
  • M Romero
  • J M Castellano
  • Melisa M L Velazquez
  • F Gaytan
  • Gunasekaran Krishnamoorthy
  • Howard H Kim
  • Hong Yu Zhou

Detail Information

Publications69

  1. ncbi Ontogenesis of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in the rat adrenal as revealed by immunocytochemistry and in situ hybridization
    E Dupont
    MRC Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Endocrinology 129:2687-92. 1991
    ..The present data suggest that 3 beta-HSD expression could well play a major role in regulating adrenal function during foetal and postnatal development...
  2. ncbi Ontogenesis of 3 beta-hydroxysteroid dehydrogenase delta 5-delta 4 isomerase in the rat ovary as studied by immunocytochemistry and in situ hybridization
    C Juneau
    MRC Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Biol Reprod 48:226-34. 1993
    ..Similar results were obtained in 40-day-old and adult animals. The present data indicate a progressive expression of 3 beta-HSD in different morphological structures during ovarian development in the rat...
  3. doi Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats
    Perumal Elumalai
    Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, 600 113, India
    Reprod Toxicol 27:41-5. 2009
    ..These results suggested that lycopene have ameliorative role against Aroclor 1254 induced Leydig cell dysfunction...
  4. ncbi Evaluation of single intratesticular injection of calcium chloride for nonsurgical sterilization in adult albino rats
    Kuladip Jana
    Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Calcutta 700 037, West Bengal, India
    Contraception 73:289-300. 2006
    ..To investigate a method of chemical sterilization and its efficacy in adult albino rats...
  5. ncbi Hypothyroidism prolongs corpus luteum function in the pregnant rat
    María Belén Hapon
    Laboratorio de Reproduccion y Lactancia, IMBECU CONICET, Mendoza, Argentina
    Reproduction 133:197-205. 2007
    ..pregnancy and, by semiquantitative RT-PCR, the expression of factors involved in P4 synthesis (CytP450scc, StAR, 3betaHSD, PRLR) and metabolism (20alphaHSD, PGF2alphaR, iNOS and COX2)...
  6. ncbi Strontium fructose 1,6-diphosphate rescues adenine-induced male hypogonadism and upregulates the testicular endothelin-1 system
    Yu Feng
    Research Division of Pharmacology, China Pharmaceutical University, Nanjing, China
    Clin Exp Pharmacol Physiol 34:1131-7. 2007
    ..These abnormalities were significantly restored by FDP-Sr in a dose-dependent manner. These data indicate the possibility of using FDP-Sr to treat male hypogonadism...
  7. doi The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue
    Scott M MacKenzie
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK
    J Endocrinol 196:123-30. 2008
    ..There is no evidence of a link between AD and altered steroid biosynthesis within human hippocampus and cerebellum...
  8. ncbi [Ginkgo biloba extract enhances testosterone synthesis of Leydig cells in type 2 diabetic rats]
    Xiao Ye Wu
    Department of Pathology, 1st Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang 325000, China
    Zhonghua Nan Ke Xue 14:371-6. 2008
    ..To investigate the effects of Ginkgo biloba extract (EGB) on the testosterone synthesis in the Leydig cells of type 2 diabetic rats...
  9. doi The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis
    A Adamsson
    Department of Physiology, University of Turku, Turku, Finland
    Int J Androl 32:575-85. 2009
    ..These changes can lead to impaired steroidogenesis and it may result in the maldevelopment of the testis and weaken masculinization...
  10. doi Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis
    Leon J S Brokken
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Endocrinology 150:445-51. 2009
    ..factor 1 (Sf1), cytochrome P450 side-chain cleavage (P450scc), 3beta-hydroxysteroid dehydrogenase type 1 (Hsd3b1), and insulin-like factor 3 (Insl3) were analyzed...
  11. ncbi Molecular study of the 3 beta-hydroxysteroid dehydrogenase gene type II in patients with hypospadias
    Ethel Codner
    Institute of Maternal and Child Research, School of Medicine, University of Chile and Hospital Clínico San Borja Arriarán, National Health Service, Santiago
    J Clin Endocrinol Metab 89:957-64. 2004
    ..We conclude that subtle molecular abnormalities in the HSD3B2 gene may be observed in some patients with apparent idiopathic hypospadias but that this finding is uncommon...
  12. ncbi Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury
    Norio Hashimoto
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Neurosci Lett 340:45-8. 2003
    ..Our results suggest that progesterone may have a role in the process against neuronal injury or in regeneration in the peripheral nervous system...
  13. ncbi Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Biochem Biophys Res Commun 293:629-32. 2002
    ..the present study was to examine the potential impact of a T-->C substitution at codon Leu(338) of the type I (HSD3B1) 3 beta-HSD gene on obesity, circulating hormones, and estimates of insulin, glucose, and lipid metabolism as well ..
  14. ncbi The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome
    V L Nelson
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 86:5925-33. 2001
    ....
  15. doi Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system
    L Pinilla
    Medical Research Council Human Reproductive Sciences Unit, Queen s Medical Research Institute, Edinburgh, United Kingdom
    Endocrinology 150:2889-97. 2009
    ....
  16. ncbi Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms
    B Viollet
    Institut Cochin de Genetique Moleculaire, U129 INSERM, Universite Rene Descartes, Paris, France
    J Biol Chem 271:1405-15. 1996
    ..Additionally, USF2b was an efficient as USF1 and USF2a homodimers in transactivating the liver-specific pyruvate kinase gene promoter...
  17. ncbi Mutations in the type II 3 beta-hydroxysteroid dehydrogenase gene in a patient with classic salt-wasting 3 beta-hydroxysteroid dehydrogenase deficiency congenital adrenal hyperplasia
    Y T Chang
    Department of Pediatrics, University of Illinois College of Medicine, Chicago 60612
    Pediatr Res 34:698-700. 1993
    ..These data indicate a homozygous combined missense/frameshift mutation in exon IV of the type II 3 beta-HSD gene resulting in severe salt-wasting adrenal and gonadal 3 beta-HSD deficiency in the patient...
  18. doi Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat
    Francisco M Zurvarra
    Department of Morphological Sciences and Center for Experimental Biology and Laboratory Animals Sciences, Faculty of Veterinary Sciences, Universidad Nacional del Litoral, Argentina
    Reprod Fertil Dev 21:827-39. 2009
    ....
  19. doi Changes in testicular morphology and steroidogenesis in adult rats exposed to Atrazine
    Anna Bolivar Victor-Costa
    Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Reprod Toxicol 29:323-31. 2010
    ..The results suggest that 3beta-HSD inhibition may represent an alternative mechanism through which Atrazine affects the testicular androgenesis, leading to changes in spermatogenesis...
  20. doi Glucocorticoid suppresses steroidogenesis in rat progenitor Leydig cells
    Ye Chen Xiao
    Population Council, New York, NY 10065, USA
    J Androl 31:365-71. 2010
    ..steady-state mRNA levels of steroidogenic acute regulatory protein (Star) and 3β-hydroxysteroid dehydrogenase 1 (Hsd3b1)...
  21. ncbi Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells
    Y Lachance
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Centre, Quebec, Canada
    J Biol Chem 265:20469-75. 1990
    ....
  22. doi A novel antagonistic effect of the bone morphogenetic protein system on prolactin actions in regulating steroidogenesis by granulosa cells
    Eri Nakamura
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama City, 700 8558, Japan
    Endocrinology 151:5506-18. 2010
    ..Considering that BMPs suppressed PRLR in granulosa cells, it is likely that the BMP system in growing follicles plays a key role in antagonizing PRLR signaling actions in the ovary exposed to high concentrations of PRL...
  23. ncbi Effects of human chorionic gonadotropin (hCG) and prolactin (PRL) on 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) expression and activity in the rat ovary
    C Martel
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Mol Cell Endocrinol 72:R7-13. 1990
    ..The present data show that hCG and PRL act synergistically to stimulate ovarian progesterone secretion via an increase in 3 beta-HSD mRNA levels, protein content and enzymatic activity...
  24. ncbi Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase cDNAs and differential tissue-specific expression of the corresponding mRNAs in steroidogenic and peripheral tissues
    H F Zhao
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Centre, Quebec, Canada
    J Biol Chem 266:583-93. 1991
    ..The present data indicate the existence of two mRNAs encoding rat 3 beta-HSD and their differential tissular distribution in both steroidogenic and peripheral tissues.(ABSTRACT TRUNCATED AT 400 WORDS)..
  25. ncbi 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase expression in rat and characterization of the testis isoform
    M C Lorence
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235 9051
    Mol Cell Endocrinol 80:21-31. 1991
    ..We conclude that while one gene product is highly expressed in testicular Leydig cells, and probably adrenal and ovary, accounting for their 3 beta-HSD content, a 3 beta-HSD is also expressed in liver in a sex-specific manner...
  26. doi Semicomprehensive analysis of the postnatal age-related changes in the mRNA expression of sex steroidogenic enzymes and sex steroid receptors in the male rat hippocampus
    Tetsuya Kimoto
    Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153 8902, Japan
    Endocrinology 151:5795-806. 2010
    ..These results suggest that the hippocampal sex steroidogenic properties are substantially altered during the postnatal development processes, which might contribute to brain sexual maturation...
  27. doi Different levels of leptin regulate different target enzymes involved in progesterone synthesis
    María Guillermina Bilbao
    Centro de Estudios Farmacológicos y Botánicos CEFYBO CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Fertil Steril 99:1460-6. 2013
    ....
  28. ncbi [Effect of L-tyrosine on 3beta-HSD activity of rat luteal cells in vitro]
    Hui Ping Wang
    Department of Physiology, Zhejiang University School of Medicine, Hangzhou 310031, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 20:190-3. 2004
    ..To study the effects of L-tyrosine on 3beta-HSD activity of rat luteal cells in vitro...
  29. doi Regulation of expression of 3β-hydroxysteroid dehydrogenase is mediated by cAMP in rat Leydig cells and H540 rat Leydig tumor cells
    D S Keeney
    Departments of Obstetrics and Gynecology and Biochemistry, Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75235 9051, USA
    J Steroid Biochem Mol Biol 43:915-22. 1992
    ..The implication of these in vitro studies is that, in vivo, LH is required to maintain optimal levels of expression of the gene encoding testicular 3βHSD...
  30. ncbi Enhanced stimulation of 5 alpha-reductase activity in cultured Leydig cell precursors by human chorionic gonadotropin
    E P Murono
    Research Service, Dorn Veterans Hospital, Columbia, SC
    J Steroid Biochem Mol Biol 48:377-84. 1994
    ....
  31. ncbi Lithium action on adrenomedullary and adrenocortical functions and serum ionic balance in different age-groups of albino rats
    S Chaudhuri-Sengupta
    Department of Zoology, University of Calcutta, Calcutta, India
    Arch Physiol Biochem 111:246-53. 2003
    ..Thus, the antimanic drug certainly disturbs both adrenomedullary and adrenocortical functions and, serum ionic balance in all the age-group of rats...
  32. doi Spearmint induced hypothalamic oxidative stress and testicular anti-androgenicity in male rats - altered levels of gene expression, enzymes and hormones
    Vikas Kumar
    Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247 667, Uttarakhand, India
    Food Chem Toxicol 46:3563-70. 2008
    ....
  33. doi Protective effect of sodium selenite and zinc sulfate on intensive swimming-induced testicular gamatogenic and steroidogenic disorders in mature male rats
    Kuladip Jana
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX 79430, USA
    Appl Physiol Nutr Metab 33:903-14. 2008
    ..It can be concluded that intensive-swimming-induced oxidative stress causes dysfunctions in the male reproductive system, which can be protected by the coadministration of sodium selenite and zinc sulfate...
  34. doi Biochemical effects of gestational coexposure to lead and cadmium on reproductive performance, placenta, and ovary
    Laxmipriya P Nampoothiri
    Department of Biochemistry, Faculty of Science, M S University of Baroda, Vadodara 390 002, Gujarat, India
    J Biochem Mol Toxicol 22:337-44. 2008
    ..Biochemical effects are correlated with metals accumulated in blood, reproductive tissue such as placenta and ovary...
  35. doi Effects of maternal toluene exposure on testosterone levels in fetal rats
    Shinji Tsukahara
    Research Center for Environmental Risk, National Institute for Environmental Studies, Onogawa 16 2, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Lett 185:79-84. 2009
    ..9 and 9 ppm, but not 0.09 ppm, toluene. These findings indicate that toluene reduced the synthesis and secretion of testosterone in fetal testes from rats possibly as a consequence of reduced 3beta-HSD expression...
  36. doi Influence of commercial dietary oils on lipid composition and testosterone production in interstitial cells isolated from rat testis
    Graciela E Hurtado de Catalfo
    Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, CCT La Plata CONICET UNLP, Catedra de Bioquimica, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, calles 60 y 120, La Plata, Argentina
    Lipids 44:345-57. 2009
    ..We conclude that dietary oils qualitatively and quantitatively modified the lipid composition of interstitial cells, producing either a direct or indirect regulatory effect on testicular steroidogenic function...
  37. pmc Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin
    Andrzej T Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 4:e4309. 2009
    ..effectively with cholesterol for the substrate binding site on P450scc and that the catalytic efficiency of 3betaHSD for 7DHP (V(m)/K(m)) is 40% of that for pregnenolone...
  38. ncbi Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome p450scc and 3beta-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cel
    N Cherradi
    Department of Internal Medicine, Faculty of Medicine, University Hospital, CH 1211 Geneva 14, Switzerland
    J Biol Chem 272:7899-907. 1997
    ....
  39. doi The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes
    Guo Xin Hu
    Institute of Molecular Toxicology and Pharmacology, Wenzhou Medical College, Zhejiang, PR China
    J Steroid Biochem Mol Biol 115:14-9. 2009
    ..As the reverse was true for the human enzymes, gossypol might be useful for treating metastatic prostate cancer...
  40. doi Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: probable mechanism of action
    Vikas Kumar
    Molecular Endocrinology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India
    Toxicology 250:124-31. 2008
    ..The study further confirmed the anti-androgenic activity of TCS in Leydig cells with highest effective concentration at 1 microM...
  41. doi Immunolocalization of androgen receptor and steroidogenic enzymes in cumuli oophori of pre- and post-ovulatory rats
    Maria Szołtys
    Department of Endocrinology and Tissue Culture, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Acta Histochem 112:576-82. 2010
    ..Simultaneous AR and cytochrome P450c17 immunolabelling in the pre- and post-ovulatory COCs is suggestive of an intra- and paracrine androgen regulation of the cumulus granulosa cell function...
  42. ncbi Identification and mechanism of action of phospholipids capable of modulating rat testicular microsomal 3 beta-hydroxysteroid dehydrogenase-isomerase activity in vitro
    G M Cooke
    Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, Quebec, Canada
    Biol Reprod 41:438-45. 1989
    ....
  43. ncbi Distribution of mercury and evaluation of testicular steroidogenesis in mercuric chloride and methylmercury administered rats
    K D Vachhrajani
    National Institute of Occupational Health, Meghani Nagar, Ahmedabad, India
    Indian J Exp Biol 28:746-51. 1990
    ..Moreover, a significant decrease in serum testosterone levels by day 90 confirmed steroidogenic impairment after MMC or MC treatment...
  44. ncbi Evidence that Leydig precursors localize in immature band two cells isolated on Percoll gradients
    E P Murono
    Research Service, Dorn Veterans Hospital, Columbia, SC
    J Steroid Biochem Mol Biol 37:675-80. 1990
    ..These results suggest that during a limited period of maturation precursor cells in Band 2, which are undetected by histochemical staining for 3 beta-HSD, can be converted to Leydig cells in culture by hCG...
  45. ncbi Regulation of expression of male-specific rat liver microsomal 3 beta-hydroxysteroid dehydrogenase
    D Naville
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics and Gynecology, University of Texas, Southwestern Medical Center, Dallas 75235 9051
    Mol Endocrinol 5:1090-100. 1991
    ..e. high apparent Km for dehydroepiandrosterone) and distinct from those of the high affinity gonadal type I 3 beta HSD.(ABSTRACT TRUNCATED AT 400 WORDS)..
  46. doi Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats
    Tatjana S Kostic
    Reproductive Endocrinology and Signaling Group, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Serbia
    Toxicol Sci 121:397-407. 2011
    ..The upregulation of AR and 3βHSD in testosterone-impaired Leydig cells steroidogenesis could be the possible mechanism that maintain and prevent loss of steroidogenic function...
  47. ncbi Expression of testicular 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase: regulation by luteinizing hormone and forskolin in Leydig cells of adult rats
    D S Keeney
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9051
    Endocrinology 130:2007-15. 1992
    ..Maximal responses were effected by 1 ng/ml ovine LH, 1 microM forskolin, 1 ng/ml cholera toxin, and 1 mM (Bu)2cAMP.(ABSTRACT TRUNCATED AT 400 WORDS)..
  48. ncbi Androgenic 17 beta-hydroxysteroid dehydrogenase activity of expressed rat type I 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase
    Y de Launoit
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Endocrinology 130:553-5. 1992
    ....
  49. doi Effects of corticosterone deficiency and its replacement on Leydig cell steroidogenesis
    C Parthasarathy
    Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, Tamil Nadu, India
    J Cell Biochem 104:1671-83. 2008
    ..Our results show that metyrapone-induced corticosterone deficiency impairs Leydig cell testosterone production by decreasing the activities of steroidogenic enzymes and their mRNA expression and glucose oxidation...
  50. ncbi Expression of androgen receptor and 3beta-hydroxysteroid dehydrogenase in corpora lutea during pregnancy in the rat
    M Szołtys
    Laboratory of Endocrinology and Tissue Culture, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Fertil Dev 19:356-65. 2007
    ..The present studies showed differences in AR and 3beta-HSD distribution within various generations of CLs and within particular regions of the same young CL...
  51. ncbi Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells
    Palaniappan Murugesan
    Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113, India
    Toxicology 232:170-82. 2007
    ..These observations suggest that vitamins C and E have ameliorative role against PCBs-induced testicular Leydig cells dysfunction...
  52. ncbi Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid
    Zhimin Shi
    Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Toxicol Sci 98:206-15. 2007
    ..Our results demonstrate that PFDoA affects the reproduction function of male rats via alterations in steroidogenesis genes, testosterone levels, and testes ultrastructure...
  53. ncbi Modulation of antioxidant defense system by the environmental fungicide carbendazim in Leydig cells of rats
    Sivasankaran Rajeswary
    Department of Zoology, Kanchi Mamunivar Centre for Post Graduate Studies, Tagore Arts College Campus, Lawspet, Pondicherry, India
    Reprod Toxicol 24:371-80. 2007
    ..Thus, the present study suggests that chronic low dose treatment of MBC is capable of inducing reproductive toxicity through increased oxidative stress, but is transient and reversible upon withdrawal of treatment...
  54. ncbi Fibroblast growth factor-9, a local regulator of ovarian function
    Ann E Drummond
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia
    Endocrinology 148:3711-21. 2007
    ..In summary, the data are consistent with a paracrine role for FGF9 in the ovary...
  55. ncbi Chromium induced testicular impairment in relation to adrenocortical activities in adult albino rats
    Amar K Chandra
    Endocrinology and Reproductive Physiology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, Kolkata 700009, West Bengal, India
    Reprod Toxicol 24:388-96. 2007
    ..Adrecortical hyperactivity accompanied by testicular oxidative stress might have a crucial role for Cr induced male reproductive impairment...
  56. pmc Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action
    Kuladip Jana
    Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, 37 and 68, K B Sarani, Calcutta 700 037, West Bengal, India
    Reprod Biol Endocrinol 4:9. 2006
    ..In this context, we evaluated the mode of action of chronic oral exposure of sodium arsenite on hypothalamo-pituitary- testicular activities in mature male albino rats...
  57. ncbi Effects of dietary fats and proteins on rat testicular steroidogenic enzymes and serum testosterone levels
    Mark J McVey
    Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Sir Fredrick G Banting Research Centre, 2202D1 Tunney s Pasture, Ottawa, ON, Canada K1A 0L2
    Food Chem Toxicol 46:259-69. 2008
    ....
  58. pmc In search of rat stem Leydig cells: identification, isolation, and lineage-specific development
    Ren Shan Ge
    Population Council, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:2719-24. 2006
    ..cells that exhibit some aspects of differentiated function, including 3beta-hydroxysteroid dehydrogenase (3betaHSD) activity...
  59. pmc Gonadotropin stimulation of ovarian fractalkine expression and fractalkine augmentation of progesterone biosynthesis by luteinizing granulosa cells
    Ping Zhao
    Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Endocrinology 149:2782-9. 2008
    ....
  60. ncbi Effect of exogenous selenium on the testicular toxicity induced by ethanol in rats
    S S Swathy
    Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram 695 001
    Indian J Physiol Pharmacol 50:215-24. 2006
    ..It also reduced the levels of testosterone and fructose. The activities of 3betaHSD, 17betaHSD in the testis and SDH in the seminal plasma were also reduced...
  61. pmc Effects of high levels of glucose on the steroidogenesis and the expression of adiponectin receptors in rat ovarian cells
    Christine Chabrolle
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    Reprod Biol Endocrinol 6:11. 2008
    ..We have recently identified AdipoR1 and AdipoR2 in rat ovary. However, their regulation in ovaries of diabetic female rat remains to be elucidated...
  62. doi Transient inhibitory effect of methoxychlor on testicular steroidogenesis in rat: an in vivo study
    S Vaithinathan
    Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry 605014, India
    Arch Toxicol 82:833-9. 2008
    ..The present study demonstrates transient effect of methoxychlor at LOAEL on testicular steroidogenesis and the possible role of hydrogen peroxide in mediating these effects...
  63. doi Inhibition of rat granulosa cell differentiation by overexpression of Galphaq
    Rosalba Escamilla-Hernandez
    Department of Cell Biology and Physiology, Magee Womens Research Institute B309, University of Pittsburgh, 204 Craft Ave, Pittsburgh, PA, 15213, USA
    Endocrine 33:21-31. 2008
    ....
  64. ncbi H2O2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis
    D K Gautam
    Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, New Mehrauli Road, Munirka, New Delhi
    Apoptosis 11:39-46. 2006
    ....
  65. doi Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis
    P J O'Shaughnessy
    Division of Cell Sciences, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Reproduction 135:851-8. 2008
    ..enzymes cytochrome P450 11a1 (Cyp11a1), cytochrome P450 17a1 (Cyp17a1), 3beta-hydroxysteroid dehydrogenase type 1 (Hsd3b1), 17beta-hydroxysteroid dehydrogenase type 3 (Hsd17b3) and the LH receptor...
  66. doi Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells
    Yun Ju Chen
    Institute of Physiology, School of Medicine, National Yang Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan
    Endocrinology 149:4658-68. 2008
    ....
  67. pmc Constitutively active protein kinase A qualitatively mimics the effects of follicle-stimulating hormone on granulosa cell differentiation
    Rosalba Escamilla-Hernandez
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Room B309, 204 Craft Avenue, Pittsburgh, Pennsylvania 15213, USA
    Mol Endocrinol 22:1842-52. 2008
    ..However, optimal induction of aromatase, the LHr, and other genes by FSH appears to require activation of additional signaling pathways...
  68. doi Effects of endocrine disrupting chemicals from leather industry effluents on male reproductive system
    Vikas Kumar
    Molecular Endocrinology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India
    J Steroid Biochem Mol Biol 111:208-16. 2008
    ..Our data suggests that the effluents from leather industry have potential EDC demonstrating androgenic activities...
  69. pmc Neurosteroids and female reproduction: estrogen increases 3beta-HSD mRNA and activity in rat hypothalamus
    K K Soma
    Department of Psychology and Zoology, Graduate Program in Neuroscience, University of British Columbia, Vancouver, Canada
    Endocrinology 146:4386-90. 2005
    ..These data support the hypothesis that PROG is a neurosteroid, produced locally in the hypothalamus from cholesterol, which functions in the estrogen positive-feedback mechanism driving the LH surge...