Hrh3

Summary

Gene Symbol: Hrh3
Description: histamine receptor H3
Alias: histamine H3 receptor, H3R, HH3R
Species: rat

Top Publications

  1. ncbi Cloning and functional expression of the human histamine H3 receptor
    T W Lovenberg
    R W Johnson Pharmaceutical Research Institute, San Diego, California, USA
    Mol Pharmacol 55:1101-7. 1999
  2. ncbi Identification of rat H3 receptor isoforms with different brain expression and signaling properties
    G Drutel
    Leiden Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands
    Mol Pharmacol 59:1-8. 2001
  3. ncbi Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata
    Sarah Threlfell
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom
    J Neurosci 24:8704-10. 2004
  4. ncbi Pre-synaptic histamine H3 receptors regulate glutamate, but not GABA release in rat thalamus
    Belén Garduño-Torres
    Departamento de Fisiologia, Biofisica y Neurociencias, Centro de Investigación y de Estudios Avanzados Cinvestav, Apdo Postal 14 740, 07000 Mexico, D F, Mexico
    Neuropharmacology 52:527-35. 2007
  5. doi H3 receptor renal expression in normal and diabetic rats
    Alessandro Pini
    Dipartimento di Medicina Sperimentale e Clinica Sezione di Anatomia e Istologia Università degli Studi di Firenze, Largo Brambilla 3, 50134, Florence, Italy
    Inflamm Res 64:271-3. 2015
  6. doi Histamine H3 receptor activation prevents dopamine D1 receptor-mediated inhibition of dopamine release in the rat striatum: a microdialysis study
    Alfonso Alfaro-Rodriguez
    Departamento de Neurorrehabilitación, Instituto Nacional de Rehabilitacion, SSA, Mexico
    Neurosci Lett 552:5-9. 2013
  7. pmc Expression of histamine receptor genes Hrh3 and Hrh4 in rat brain endothelial cells
    K Karlstedt
    Institute of Biomedicine, Physiology, Biomedicum Helsinki, University of Helsinki, Finland
    Br J Pharmacol 170:58-66. 2013
  8. doi The role of cortical and hypothalamic histamine-3 receptors in the modulation of central histamine neurotransmission: an in vivo electrophysiology and microdialysis study
    Gunnar Flik
    Department of Biomonitoring and Sensoring, Groningen Research Institute of Pharmacy GRIP, University of Groningen, Groningen, The Netherlands
    Eur J Neurosci 34:1747-55. 2011
  9. ncbi Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles
    T W Lovenberg
    R W Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 293:771-8. 2000
  10. pmc Identification and characterization of ZEL-H16 as a novel agonist of the histamine H3 receptor
    Ying Shi
    College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang Province, China
    PLoS ONE 7:e42185. 2012

Scientific Experts

  • T W Lovenberg
  • Ryo Shimada
  • G Coruzzi
  • Kjell Malmlöf
  • Ren Iwata
  • Nikolai E Lazarov
  • A D Medhurst
  • Kaj Karlstedt
  • Siavoush Dastmalchi
  • H S Sharma
  • G Morini
  • Artur Dembinski
  • Hiroshi Azuma
  • M Hajos
  • W W Pawlik
  • Belén Garduño-Torres
  • F Gbahou
  • Pertti Panula
  • Minnamaija Lintunen
  • Paul L Chazot
  • Jose Antonio Arias-Montaño
  • Alessandro Pini
  • Alfonso Alfaro-Rodriguez
  • Ying Shi
  • J M Arrang
  • S Morisset
  • Pengyuan Sun
  • Gunnar Flik
  • Estefania Moreno
  • Patrizia Giannoni
  • Wenyong Ding
  • D Moreno-Delgado
  • S Suzuki
  • Jordi Ortiz
  • Kay Maeda
  • Fiona C Shenton
  • Kazuhiko Yanai
  • P Chazot
  • Yoshihito Funaki
  • Keyue Liu
  • Takumi Nagaro
  • Naoto Adachi
  • Liang Huang
  • Tatsuru Arai
  • Norihito Hiraga
  • J B Shaw
  • Haibin Dai
  • Patrizio Blandina
  • Rob Leurs
  • Remko A Bakker
  • Sayaka Ito
  • Daniela Grandi
  • A Rouleau
  • Tiina Kaisa Kukko-Lukjanov
  • Walter Schunack
  • Anna Torrent
  • Elisabetta Baldi
  • F C Shenton
  • A Lozada
  • Congyu Jin
  • Satoshi Yamamoto
  • C Harada
  • Sarah Threlfell
  • W Schunack
  • P Panula
  • R Leurs
  • Aldo Moggio
  • Eleonora Veglia
  • Arianna Carolina Rosa
  • Antonio Bueno-Nava
  • Emilio Arch-Tirado
  • Rigoberto Gonzalez-Pina
  • María Alonso-Spilsbury
  • G Drutel
  • Fenyan Yang
  • Yu Xu
  • Tingting Zhong
  • Dong Yang
  • Yi Sun
  • Yongzhou Hu
  • T Yamano
  • Xiaopan Chen
  • Rong Sheng
  • Naiming Zhou
  • J C Schwartz
  • Joost H A Folgering
  • Sergi Ferre
  • J Tardivel-Lacombe
  • Panot Tangsucharit
  • Hiromu Kawasaki

Detail Information

Publications57

  1. ncbi Cloning and functional expression of the human histamine H3 receptor
    T W Lovenberg
    R W Johnson Pharmaceutical Research Institute, San Diego, California, USA
    Mol Pharmacol 55:1101-7. 1999
    ..The existence of the histamine H3 receptor was demonstrated pharmacologically 15 years ago, yet despite intensive efforts, its molecular identity has ..
  2. ncbi Identification of rat H3 receptor isoforms with different brain expression and signaling properties
    G Drutel
    Leiden Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands
    Mol Pharmacol 59:1-8. 2001
    ..The heterogeneous distribution of the isoforms suggests that H3 receptor isoform-specific regulation is important in several brain functions...
  3. ncbi Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata
    Sarah Threlfell
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom
    J Neurosci 24:8704-10. 2004
    ..Selective H3R agonists (R)-(-)-alpha-methyl-histamine or immepip inhibited evoked 5-HT release by up to 60%...
  4. ncbi Pre-synaptic histamine H3 receptors regulate glutamate, but not GABA release in rat thalamus
    Belén Garduño-Torres
    Departamento de Fisiologia, Biofisica y Neurociencias, Centro de Investigación y de Estudios Avanzados Cinvestav, Apdo Postal 14 740, 07000 Mexico, D F, Mexico
    Neuropharmacology 52:527-35. 2007
    ..38+/-0.05) in a paired-pulse paradigm. Taken together, our results confirm the presence of H(3)Rs on thalamic nerve terminals and show that their activation modulates pre-synaptically glutamatergic, but not GABAergic neurotransmission...
  5. doi H3 receptor renal expression in normal and diabetic rats
    Alessandro Pini
    Dipartimento di Medicina Sperimentale e Clinica Sezione di Anatomia e Istologia Università degli Studi di Firenze, Largo Brambilla 3, 50134, Florence, Italy
    Inflamm Res 64:271-3. 2015
    To extend our previous observation of H4R upregulation in the kidney of diabetic rats, we evaluated in the same specimens the presence of the H3R.
  6. doi Histamine H3 receptor activation prevents dopamine D1 receptor-mediated inhibition of dopamine release in the rat striatum: a microdialysis study
    Alfonso Alfaro-Rodriguez
    Departamento de Neurorrehabilitación, Instituto Nacional de Rehabilitacion, SSA, Mexico
    Neurosci Lett 552:5-9. 2013
    ..5 and 1 μM) significantly reduced DA release (26-58%), and this effect was prevented by co-administration of the H3R agonist immepip (10 μM). In turn, the effect of immepip was blocked by the H3R antagonist thioperamide (10 μM)...
  7. pmc Expression of histamine receptor genes Hrh3 and Hrh4 in rat brain endothelial cells
    K Karlstedt
    Institute of Biomedicine, Physiology, Biomedicum Helsinki, University of Helsinki, Finland
    Br J Pharmacol 170:58-66. 2013
    ..We investigated whether H3 and H4 receptors are also expressed in these cells and may thus play a role in permeability regulation...
  8. doi The role of cortical and hypothalamic histamine-3 receptors in the modulation of central histamine neurotransmission: an in vivo electrophysiology and microdialysis study
    Gunnar Flik
    Department of Biomonitoring and Sensoring, Groningen Research Institute of Pharmacy GRIP, University of Groningen, Groningen, The Netherlands
    Eur J Neurosci 34:1747-55. 2011
    ..As the brain histamine system has a role in pathophysiology of psychotic, affective, cognitive, sleep and eating disorders, H(3) receptors are potential targets for future CNS medications...
  9. ncbi Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles
    T W Lovenberg
    R W Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 293:771-8. 2000
    ..It also was found that chloroproxyfan behaved as a full agonist at the rat recombinant receptor. These findings highlight the significance of validating the pharmacology of experimental compounds at both the rat and human H(3) receptors...
  10. pmc Identification and characterization of ZEL-H16 as a novel agonist of the histamine H3 receptor
    Ying Shi
    College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang Province, China
    PLoS ONE 7:e42185. 2012
    The histamine H3 receptor (H3R) has been recognized as a promising target for the treatment of various central and peripheral nervous system diseases...
  11. pmc The histamine autoreceptor is a short isoform of the H₃ receptor
    F Gbahou
    Laboratoire de Neurobiologie et Pharmacologie Moléculaire, Centre de Psychiatrie et Neurosciences CPN, U 894, INSERM, Paris, France
    Br J Pharmacol 166:1860-71. 2012
    ..Development of drugs selectively targeting autoreceptors might enhance their therapeutic efficacy and/or decrease incidence of side effects...
  12. doi A rat model of changes in dural mast cells and brain histamine receptor H3 expression following traumatic brain injury
    Ryo Shimada
    Department of Legal Medicine, School of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    J Clin Neurosci 19:447-51. 2012
    ..Histamine plays a role in the development of brain edema and can induce histamine receptor H3 (HRH3) expression in the brain to provide protective feedback effects against histamine neurotoxicity...
  13. ncbi The rat H3 receptor: gene organization and multiple isoforms
    S Morisset
    Unité de Neurobiologie et Pharmacologie Moléculaire U109 de L INSERM, Centre Paul Broca, 2 ter rue d Alesia, Paris, 75014, France
    Biochem Biophys Res Commun 280:75-80. 2001
    Genomic DNA analysis revealed that the coding region of the rat histamine H3 receptor comprises three exons interrupted by two introns of approximately 1 kb each...
  14. doi Selective histamine H₃ and H₄ receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach
    Gabriella Coruzzi
    Department of Human Anatomy, Pharmacology and Forensic Medicine, Section of Pharmacology, University of Parma, 43100 Parma, Italy
    Eur J Pharmacol 669:121-7. 2011
    ..Finally, the species-dependent variations in affinity and receptor selectivity observed for most ligands need to be carefully addressed in the pharmacological characterization of histamine H(3) and H(4) receptor functions in vivo...
  15. doi Different role of cAMP dependent protein kinase and CaMKII in H3 receptor regulation of histamine synthesis and release
    D Moreno-Delgado
    Universitat Autonoma de Barcelona, Neuroscience Institute and Department of Biochemistry and Molecular Biology, School of Medicine, 08193 Bellaterra, Spain
    Neuroscience 164:1244-51. 2009
    ..These results indicate that H(3) autoreceptors regulate neuronal histamine release (1) independently of the cAMP/PKA cascade, and (2) through modulation of calcium entry and CaMKII activation during depolarization...
  16. ncbi The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons
    Haibin Dai
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, and Department of Pharmacy, Second Affiliated Hospital, China
    Eur J Pharmacol 563:117-23. 2007
    Using the histamine H3 receptor antagonist clobenpropit, the roles of histamine H3 receptors in NMDA-induced necrosis were investigated in rat cultured cortical neurons...
  17. ncbi Heterogeneity of histamine H3 receptor genomic expression in the cerebral cortex of spontaneously hypertensive rat
    J B Shaw
    Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA
    Cell Mol Biol (Noisy-le-grand) 53:45-50. 2007
    ....
  18. ncbi Molecular modeling of histamine H3 receptor and QSAR studies on arylbenzofuran derived H3 antagonists
    Siavoush Dastmalchi
    School of Pharmacy, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz 51664, Iran
    J Mol Graph Model 26:834-44. 2008
    ..The results of this investigation are expected to be useful in the process of design and development of new potent H3 receptor antagonists...
  19. ncbi Influence of (R)-alpha-methylhistamine on the histamine H3 receptor in the rat gastrointestinal tract
    P Chazot
    Center for Integrative Neurosciences CINS, School of Biological and Biomedical Sciences, Durham University, Durham, DH15NQ, UK
    Inflamm Res 56:S19-20. 2007
  20. ncbi Modulation of hippocampal theta oscillation by histamine H3 receptors
    M Hajos
    Department of Neuroscience, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    J Pharmacol Exp Ther 324:391-8. 2008
    ....
  21. ncbi Evaluation of the binding characteristics of [18F]fluoroproxyfan in the rat brain for in vivo visualization of histamine H3 receptor
    Yoshihito Funaki
    Department of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai 980 8578, Japan
    Nucl Med Biol 34:981-7. 2007
    ..These data suggest that [18F]fluoroproxyfan can be potentially useful to image histamine H3 receptor noninvasively in the human brain by positron emission tomography.
  22. doi CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression
    Kay Maeda
    Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 369:603-8. 2008
    b>Histamine H3 receptor (H3R), one of G protein-coupled receptors (GPCRs), has been known to regulate neurotransmitter release negatively in central and peripheral nervous systems...
  23. doi Histamine H3 and H4 receptors are expressed on distinct endocrine cell types in the rat fundic mucosa
    G Morini
    Department of Human Anatomy, Pharmacology and Forensic Medicine, University of Parma, 43100 Parma, Italy
    Inflamm Res 57:S57-8. 2008
  24. doi Localization and function of histamine H3 receptor in the nasal mucosa
    S Suzuki
    Department of Otorhinolaryngology Head and Neck Surgery, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Clin Exp Allergy 38:1476-82. 2008
    ..However, little is known about the localization and function of H(3)R in the upper airway...
  25. doi Multiple sequence elements determine the intron retention in histamine H3 receptors in rats and mice
    Wenyong Ding
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China
    Int J Biochem Cell Biol 41:2281-6. 2009
    ..The results provide insight into special alternative splicing regulation in H(3) receptors...
  26. doi Heterogeneity of histaminergic neurons in the tuberomammillary nucleus of the rat
    Patrizia Giannoni
    Dipartimento di Farmacologia Preclinica e Clinica, V le G Pieraccini 6, Universita di Firenze, 50139 Firenze, Italy
    Eur J Neurosci 29:2363-74. 2009
    ..This is the first evidence that histaminergic neurons are organized into functionally distinct circuits that influence different brain regions, and display selective control mechanisms...
  27. ncbi Histaminergic involvement in neuropathic pain produced by partial ligation of the sciatic nerve in rats
    Liang Huang
    Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
    Reg Anesth Pain Med 32:124-9. 2007
    ..Because the histaminergic system in the brain is involved in regulation of pain, the relationship between central histaminergic activity and neuropathic pain is of interest...
  28. pmc Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway
    Estefania Moreno
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Diagonal 645, 08028 Barcelona, Spain
    J Biol Chem 286:5846-54. 2011
    ..These results indicate that D(1)-H(3) receptor heteromers work as processors integrating dopamine- and histamine-related signals involved in controlling the function of striatal neurons of the direct striatal pathway...
  29. doi Histamine H(3) receptor-mediated modulation of perivascular nerve transmission in rat mesenteric arteries
    Pengyuan Sun
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Eur J Pharmacol 655:67-73. 2011
    ..These results suggest that the stimulation of H(3) receptors located in rat perivascular nerves inhibits presynaptically the neurotransmission of not only adrenergic nerves, but also CGRP nerves, by decreasing neurotransmitters...
  30. ncbi High constitutive activity of native H3 receptors regulates histamine neurons in brain
    S Morisset
    Unité de Neurobiologie et Pharmacologie Moléculaire U 109 de l INSERM, Centre Paul Broca, Paris, France
    Nature 408:860-4. 2000
    ..Inverse agonists may therefore find therapeutic applications, even in the case of diseases involving non-mutated receptors expressed at normal levels...
  31. ncbi Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats
    G Godlewski
    Zaklad Farmakodynamiki, Akademia Medyczna, Bialystok, Poland
    Naunyn Schmiedebergs Arch Pharmacol 355:261-6. 1997
    ..Moreover, it demonstrates that these H3 receptors are probably activated by endogenous histamine and appear to be operative in hypertension...
  32. ncbi Presynaptic localization of histamine H3-receptors in rat brain
    K Fujimoto
    Department of Pharmacology II, Faculty of Medicine, Osaka University, Japan
    Biochem Biophys Res Commun 177:907-12. 1991
    ..Only a negligible amount was recovered in the MYE fraction, unlike the histamine H3- and adrenaline alpha 2-receptors...
  33. ncbi Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor
    Sayaka Ito
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Tsukuba, Ibaraki 300 2611, Japan
    Eur J Pharmacol 529:40-6. 2006
    ..Thus, GT-2331 displayed the spectrum of pharmacological activities from full agonism to full antagonism, these observations suggest that histamine H(3) receptor ligands need to be carefully evaluated in various paradigms...
  34. ncbi Role of histamine H3 receptors during ischemia/reperfusion in isolated rat hearts
    Satoshi Yamamoto
    Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Osaka, Japan
    J Cardiovasc Pharmacol 43:353-7. 2004
    ..Thus, it seems likely that the ischemia/reperfusion-induced carrier-mediated NE release in rat hearts is negatively regulated by the activation of H3 receptors, probably located on cardiac noradrenergic nerve endings...
  35. ncbi Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia
    C Harada
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Methods Find Exp Clin Pharmacol 26:263-70. 2004
    ..These results indicate that some H3 antagonists may be useful as antiepileptic drugs, especially for secondary generalized seizures and/or tonic-clonic seizures in humans...
  36. ncbi Histamine H3 receptors modulate reactive hyperemia in rat gut
    W W Pawlik
    Department of Physiology, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 55:651-61. 2004
    ..Hyperemia parameters were determined before and after administration of the selective histamine H3 receptor antagonist clobenpropit...
  37. ncbi H3 autoreceptors modulate histamine synthesis through calcium/calmodulin- and cAMP-dependent protein kinase pathways
    Anna Torrent
    Universitat Autonoma de Barcelona, Dept Biochemistry and Molecular Biology, School of Medicine, Neuroscience Institute, Room M2 120, E 08193 Bellaterra, Spain
    Mol Pharmacol 67:195-203. 2005
    ..These results show how depolarization activates histamine synthesis in nerve endings and demonstrate that both pathways modulating neurotransmitter synthesis are controlled by H(3) autoreceptors...
  38. ncbi Expression of mRNA encoding the H1, H2, and H3 histamine receptors in the rat cochlea
    Hiroshi Azuma
    Department of Otolaryngology, Kochi Medical School, Japan
    Neuroreport 14:423-5. 2003
    ..This is the first evidence of H1, H2, and H3 histamine receptor mRNA in the rat cochlea. These findings support the suggestion that histamine may play a physiological role in the cochlea...
  39. ncbi Role of capsaicin-sensitive nerves and histamine H1, H2, and H3 receptors in the gastroprotective effect of histamine against stress ulcers in rats
    Artur Dembinski
    Department of Physiology, Jagiellonian University Medical School, 16 Grzegorzecka Street, Krakow 31 531, Poland
    Eur J Pharmacol 508:211-21. 2005
    ..antagonist pyrilamine (100 micromol/kg), histamine H2 receptor antagonist ranitidine (100 micromol/kg), histamine H3 receptor antagonist thioperamide (100 micromol/kg), or a combination of histamine with these histamine receptor ..
  40. ncbi The H3 receptor protean agonist proxyfan enhances the expression of fear memory in the rat
    Elisabetta Baldi
    Dipartimento di Science Fisiologiche, Universita di Firenze, Viale Morgagni 63, 50134 Firenze, Italy
    Neuropharmacology 48:246-51. 2005
    ..The histamine H3 receptor is a G-protein-coupled receptor (GPCR) displaying high constitutive activity that regulates histamine ..
  41. ncbi Histamine H(1) and H(3) receptors in the rat thalamus and their modulation after systemic kainic acid administration
    Congyu Jin
    Department of Biology, Abo Akademi University, BioCity, Tykistokatu 6A, FIN 20520 Turku, Finland
    Exp Neurol 194:43-56. 2005
    ..The elevations in H(3) binding were evident in the intralaminar area, laterodorsal, lateral posterior, posterior and geniculate nuclei, and were likely to be related to the cortical and subcortical inputs to thalamus...
  42. ncbi Evidence for native and cloned H3 histamine receptor higher oligomers
    F C Shenton
    School of Biological and Biomedical Sciences, University of Durham, South Road, DH1 3LE, Durham, UK
    Inflamm Res 54:S48-9. 2005
  43. ncbi Transient changes in the limbic histaminergic system after systemic kainic acid-induced seizures
    Minnamaija Lintunen
    Department of Biology, Abo Akademi University, BioCity, Tykistokatu 6A, FIN 20520 Turku, Finland
    Neurobiol Dis 20:155-69. 2005
    ..These results suggest that histamine and H3 receptors, which also control the release of GABA and glutamate, might be involved in convulsive SE...
  44. ncbi Postischemic regulation of central histamine receptors
    A Lozada
    Department of Biology, Abo Akademi University, BioCity, Artillerigatan 6A, FIN 20520 Turku, Finland
    Neuroscience 136:371-9. 2005
    ..Our data suggest that central histamine receptor expression and ligand binding are altered in brain ischemia in distinct areas, and may participate in neuroprotection and/or ischemia-associated neuronal damage...
  45. ncbi Expression of the H3 receptor in the developing CNS and brown fat suggests novel roles for histamine
    Kaj Karlstedt
    Department of Biology, Abo Akademi University, BioCity, Artillerigatan 6A, FIN 20520 Turku, Finland
    Mol Cell Neurosci 24:614-22. 2003
    ....
  46. ncbi Discovery of naturally occurring splice variants of the rat histamine H3 receptor that act as dominant-negative isoforms
    Remko A Bakker
    The Leiden Amsterdam Center for Drug Research, Department of Medicinal Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081HV Amsterdam, The Netherlands
    Mol Pharmacol 69:1194-206. 2006
    We described previously the cDNA cloning of three functional rat histamine H3 receptor (rH3R) isoforms as well as the differential brain expression patterns of their corresponding mRNAs and signaling properties of the resulting rH3A, ..
  47. ncbi Histaminergic neurons protect the developing hippocampus from kainic acid-induced neuronal damage in an organotypic coculture system
    Tiina Kaisa Kukko-Lukjanov
    Department of Pharmacology and Clinical Pharmacology, University of Turku, FIN 20520 Turku, Finland
    J Neurosci 26:1088-97. 2006
    ..Our results suggest that histaminergic neurons protect the developing hippocampus from KA-induced neuronal damage, with regulation of neuronal survival being at least partly mediated through H1 and H3 receptors...
  48. ncbi Histamine receptors influence blood-spinal cord barrier permeability, edema formation, and spinal cord blood flow following trauma to the rat spinal cord
    H S Sharma
    Department of Surgical Sciences, Anesthesiology and Intensive Care, University Hospital, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 96:316-21. 2006
    ..The effects of ranitidine were far superior to cimetidine in identical doses. Pretreatment with a histamine H3 receptor agonist alpha-methylhistamine (1 mg and 2 mg/kg/i.p...
  49. ncbi Epithelial cell proliferation is promoted by the histamine H(3) receptor agonist (R)-alpha-methylhistamine throughout the rat gastrointestinal tract
    Daniela Grandi
    Department of Human Anatomy, Pharmacology and Forensic Medicine, University of Parma, 43100 Parma, Italy
    Eur J Pharmacol 538:141-7. 2006
    ..Present data support a role of histamine H(3) receptors in the normal regulation of cell cycle in epithelial tissue...
  50. ncbi Homologous down-regulation of histamine H3 receptors in rat striatal slices
    Belén Garduño-Torres
    Departamento de Fisiologia, Biofisica y Neurociencias, Centro de Investigacion y de Estudios Avanzados, Apdo Postal 14 740, 07000 Mexico, D F, Mexico
    Synapse 60:165-71. 2006
    ..76% +/- 4% of control values). Taken together our results indicate that agonist binding promotes the down-regulation of striatal H3 receptors resulting in a significant loss of function...
  51. ncbi Selective expression of histamine receptors in rat mesencephalic trigeminal neurons
    Nikolai E Lazarov
    Department of Anatomy, Faculty of Medicine, Thracian University, Stara Zagora, Bulgaria
    Neurosci Lett 404:67-71. 2006
    ..It can be inferred that processing of proprioceptive information at the level of the MTN is controlled via histamine H1 and H3 receptors through different postsynaptic mechanisms...
  52. ncbi Effect of L-carnosine on the hyperglycemia caused by intracranial injection of 2-deoxy-D-glucose in rats
    T Yamano
    Division of Protein Metabolism, Institute for Protein Research, Osaka University, 3 2 Yamada Oka, Suita, Osaka 565 0871, Japan
    Neurosci Lett 313:78-82. 2001
    ..Considering mammalian muscles contain L-carnosine, these facts suggest a possibility that L-carnosine might be an endogenous control factor of the blood glucose level through autonomic nerves via H3-receptor...
  53. ncbi Suppression of inflammatory cell recruitment by histamine receptor stimulation in ischemic rat brains
    Norihito Hiraga
    Department of Anesthesiology and Resuscitology, Ehime University Graduate School of Medicine, Shitsukawa, Touon shi, Ehime 791 0295, Japan
    Eur J Pharmacol 557:236-44. 2007
    ..effects of postischemic administration of L-histidine, a precursor of histamine, and thioperamide, a histamine H3 receptor antagonist, on inflammatory cell infiltration were evaluated in a rat model of transient occlusion of the ..
  54. ncbi Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides
    Kjell Malmlöf
    Department of Diabetes Pharmacology, Novo Nordisk A S, Novo Nordisk Park, 2760 Måløv, Denmark
    Obesity (Silver Spring) 14:2154-62. 2006
    ..The purpose of the present study was to examine the metabolic effects of a specific histamine H(3) receptor antagonist, the cinnamic amide NNC 0038-0000-1202 (NNC 38-1202)...
  55. ncbi Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats
    Andrew D Medhurst
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Avenue, Harlow, Essex CM19 5AW, UK
    Biochem Pharmacol 73:1182-94. 2007
    ..Novel H(3) receptor antagonists such as GSK207040 and GSK334429 may therefore have therapeutic potential not only in dementia but also in neuropathic pain...
  56. ncbi GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models
    Andrew D Medhurst
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Ave, Harlow, Essex, CM19 5AW, UK
    J Pharmacol Exp Ther 321:1032-45. 2007
    ..3 and 1 mg/kg p.o.), and attentional set shift (1 mg/kg p.o.). These data suggest that GSK189254 may have therapeutic potential for the symptomatic treatment of dementia in Alzheimer's disease and other cognitive disorders...