Hmox1

Summary

Gene Symbol: Hmox1
Description: heme oxygenase 1
Alias: HEOXG, Heox, Hmox, Ho-1, Ho1, hsp32, heme oxygenase 1, heme oxygenase (decycling) 1, heme oxygenase (decyclizing) 1
Species: rat

Top Publications

  1. ncbi An analysis of the DOCA-salt model of hypertension in HO-1-/- mice and the Gunn rat
    Karl A Nath
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 293:H333-42. 2007
  2. ncbi Posttranslational and direct integration of heme oxygenase into microsomes
    T Yoshida
    Department of Molecular and Pathological Biochemistry, Yamagata University School of Medicine, Japan
    Biochem Biophys Res Commun 163:1086-92. 1989
  3. pmc Cloning and expression of cDNA for rat heme oxygenase
    S Shibahara
    Proc Natl Acad Sci U S A 82:7865-9. 1985
  4. ncbi Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis
    P K Datta
    Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick 08903, USA
    J Am Soc Nephrol 10:2540-50. 1999
  5. ncbi Heme oxygenase-1 reduces murine monocrotaline-induced pulmonary inflammatory responses and resultant right ventricular overload
    Jun Goto
    First Department of Internal Medicine, Fukushima Medical University, Fukushima, Japan
    Antioxid Redox Signal 4:563-8. 2002
  6. ncbi Facilitated angiogenesis induced by heme oxygenase-1 gene transfer in a rat model of hindlimb ischemia
    Masatoshi Suzuki
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo ku Hongo 7 3 1, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 302:138-43. 2003
  7. ncbi Heme oxygenase-1 and the ischemia-reperfusion injury in the rat heart
    Emanuela Masini
    Departments of Preclinical and Clinical Pharmacology, University of Florence, 50139, Florence, Italy
    Exp Biol Med (Maywood) 228:546-9. 2003
  8. ncbi Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse
    Jesus A Araujo
    Division of Cardiology, University of California, Los Angeles, CA 90095, USA
    J Immunol 171:1572-80. 2003
  9. ncbi Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection
    Tzong Shyuan Lee
    Division of Biomedical Sciences, University of California, Riverside, CA 92521 0121, USA
    Circulation 110:1296-302. 2004
  10. ncbi Protection from cardiac injury by induction of heme oxygenase-1 and nitric oxide synthase in a focal ischaemia-reperfusion model
    L Giannini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Cell Mol Biol (Noisy-le-grand) 51:393-401. 2005

Research Grants

  1. Karl A Nath; Fiscal Year: 2016
  2. Regulation of Vascular Tone During Cirrhosis
    ETHAN CARTER; Fiscal Year: 2003
  3. Regulation of Pulmonary Vascular Tone During Cirrhosis
    CHRYSTELLE GARAT CARTER; Fiscal Year: 2004
  4. Role of Cysteine-rich Protein 2 in Vascular Disease
    Shaw Fang Yet; Fiscal Year: 2005
  5. Development of neuromuscular junctions in children with cerebral palsy
    Robert Akins; Fiscal Year: 2008

Detail Information

Publications143 found, 100 shown here

  1. ncbi An analysis of the DOCA-salt model of hypertension in HO-1-/- mice and the Gunn rat
    Karl A Nath
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 293:H333-42. 2007
    ..DOCA salt stimulated vascular production of superoxide anion in wild-type but not in Gunn rats. We suggest that HO-1 and the product bilirubin may exert a countervailing effect in the DOCA-salt model of systemic hypertension...
  2. ncbi Posttranslational and direct integration of heme oxygenase into microsomes
    T Yoshida
    Department of Molecular and Pathological Biochemistry, Yamagata University School of Medicine, Japan
    Biochem Biophys Res Commun 163:1086-92. 1989
    ..Heme oxygenase synthesized in a cell-free system or purified from microsomes after detergent-solubilization was integrated into microsomal membranes posttranslationally and directly, like cytochrome b5...
  3. pmc Cloning and expression of cDNA for rat heme oxygenase
    S Shibahara
    Proc Natl Acad Sci U S A 82:7865-9. 1985
    ..RNA blot analysis showed that both CoCl2 and hemin increased the amount of hybridizable mRNA, suggesting that these substances may act at the transcriptional level to increase the amount of heme oxygenase...
  4. ncbi Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis
    P K Datta
    Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick 08903, USA
    J Am Soc Nephrol 10:2540-50. 1999
    ..The beneficial effect of hemin treatment on proteinuria could be linked to downregulation of iNOS...
  5. ncbi Heme oxygenase-1 reduces murine monocrotaline-induced pulmonary inflammatory responses and resultant right ventricular overload
    Jun Goto
    First Department of Internal Medicine, Fukushima Medical University, Fukushima, Japan
    Antioxid Redox Signal 4:563-8. 2002
    ..Interestingly, inhibition of HO activity promoted inflammatory changes in the lung and the resultant RV hypertrophy. HO-1 may play defensive roles against murine MT-induced pulmonary inflammation and the resultant RV overload...
  6. ncbi Facilitated angiogenesis induced by heme oxygenase-1 gene transfer in a rat model of hindlimb ischemia
    Masatoshi Suzuki
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo ku Hongo 7 3 1, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 302:138-43. 2003
    ..Thus, HO-1 gene transfer improves the blood flow in ischemic hindlimb, at least in part, via angiogenesis facilitated by the induction of this molecule...
  7. ncbi Heme oxygenase-1 and the ischemia-reperfusion injury in the rat heart
    Emanuela Masini
    Departments of Preclinical and Clinical Pharmacology, University of Florence, 50139, Florence, Italy
    Exp Biol Med (Maywood) 228:546-9. 2003
    ..These effects were prevented by the HO-1 inhibitor ZnPP-IX. The present experiments show that the concerted actions of CO, iron, and biliverdin/bilirubin modulate the FIR-induced myocardial injury...
  8. ncbi Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse
    Jesus A Araujo
    Division of Cardiology, University of California, Los Angeles, CA 90095, USA
    J Immunol 171:1572-80. 2003
    ..This Tg mouse provides a valuable tool to study mechanisms by which HO-1 exerts beneficial effects in organ transplantation...
  9. ncbi Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection
    Tzong Shyuan Lee
    Division of Biomedical Sciences, University of California, Riverside, CA 92521 0121, USA
    Circulation 110:1296-302. 2004
    ..Here, we studied whether heme oxygenase-1 (HO-1), an important cytoprotective molecule, is induced by simvastatin and the role of HO-1 in the pleiotropic effects of simvastatin...
  10. ncbi Protection from cardiac injury by induction of heme oxygenase-1 and nitric oxide synthase in a focal ischaemia-reperfusion model
    L Giannini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Cell Mol Biol (Noisy-le-grand) 51:393-401. 2005
    ....
  11. ncbi Increase in heme oxygenase-1 levels ameliorates renovascular hypertension
    Fady T Botros
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Kidney Int 68:2745-55. 2005
    ..We examined whether HO-1 overexpression, as a prophylactic approach, would attenuate renovascular hypertension and evaluated potential mechanisms that may account for its effect...
  12. ncbi Heme oxygenase-1 protects rat kidney from ureteral obstruction via an antiapoptotic pathway
    Jin Hyun Kim
    Department of Internal Medicine, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Chilam dong 92, Jinju, Gyeongnam 660 751, Republic of Korea
    J Am Soc Nephrol 17:1373-81. 2006
    ..This study demonstrates that upregulation of HO-1 provides protection against renal injury that follows UUO. This effect is dependent on modulation of the antiapoptotic pathway by HO-1 expression...
  13. ncbi Heme oxygenase 1 expression in rat liver during ageing and ethanol intoxication
    Stefania Patriarca
    Department of Experimental Medicine, Section of General Pathology, University of Genova, Via L B Alberti 2, 16132, Genova, Italy
    Biogerontology 8:365-72. 2007
    b>Heme oxygenase 1 (HO-1) expression is recognized as a marker of cellular response to oxidative stress; since ageing is believed to be related to oxidative "wear and tear", HO-1 may represent a candidate biomarker of ageing...
  14. ncbi Heme oxygenase-1 protects against radiocontrast-induced acute kidney injury by regulating anti-apoptotic proteins
    A I Goodman
    Department of Pharmacology, New York Medical College, Valhalla, New York, USA
    Kidney Int 72:945-53. 2007
    ..Our study suggests that increased levels of heme oxygenase-1 are protective against acute kidney injury due to radiocontrast exposure...
  15. ncbi Heme oxygenase-1 inducer hemin prevents vascular thrombosis
    Nicolas Desbuards
    LABPART EA 3852 IFR135 Université François Rabelais, Tours Cedex 1, France
    Thromb Haemost 98:614-20. 2007
    ..In conclusion, hemin by inducing HO-1 expression may be a preventive agent against clinical disorders associated to an increased risk of thrombosis events and may limit haemorrhagic risks...
  16. doi Cobalt protoporphyrin attenuates rat obstructive nephropathy: role of cellular infiltration
    Tomoaki Iwai
    Department of Urology, Osaka City University Medical School, Osaka, Japan
    Urology 72:432-8. 2008
    ..To elucidate the antifibrogenic mechanisms of HO-1, we examined the effect of HO-1 induction on renal interstitial inflammation...
  17. doi Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells
    Dong Hyun Kim
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 325:833-40. 2008
    ..These findings highlight the pivotal role and symbiotic relationship of HO-1 and adiponectin in the modulation of the metabolic syndrome phenotype...
  18. doi Pharmacological preconditioning with simvastatin protects liver from ischemia-reperfusion injury by heme oxygenase-1 induction
    I Rue Lai
    Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan 2
    Transplantation 85:732-8. 2008
    ..The feasible candidates who induce HO-1 and thorough which exert the protective effects are under investigation. The aim was to study the role of HO-1 in pharmacological preconditioning by simvastatin in a rat model...
  19. doi Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1
    Jun Te Hsu
    Dept of Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan corrected
    Am J Physiol Regul Integr Comp Physiol 294:R1825-31. 2008
    ..These results suggest that the p38 MAPK/HO-1 pathway plays a critical role in mediating the salutary effects of E(2) on shock-induced intestinal injury...
  20. doi Hypoxia-inducible factor 1/heme oxygenase 1 cascade as upstream signals in the prolife role of heat shock protein 70 at rostral ventrolateral medulla during experimental brain stem death
    Alice Y W Chang
    Center for Translational Research in Biomedical Sciences, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung County, Republic of China
    Shock 32:651-8. 2009
    ..significant hypoxia in RVLM, this study evaluated the hypothesis that the hypoxia-inducible factor 1 (HIF-1)/heme oxygenase 1 (HO-1) cascade acts as upstream signals in the prolife role of HSP70 at RVLM during experimental brain stem ..
  21. doi Elevation of heme oxygenase-1 by proteasome inhibition affords dopaminergic neuroprotection
    Noriyuki Yamamoto
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 88:1934-42. 2010
    ..These results suggest that mesencephalic HO-1 protein level is regulated by proteasome activity and the elevation by proteasome inhibition affords neuroprotection...
  22. pmc Postischemic cardiac recovery in heme oxygenase-1 transgenic ischemic/reperfused mouse myocardium
    Bela Juhasz
    Department of Pharmacology, Health Science Center, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary
    J Cell Mol Med 15:1973-82. 2011
    ..Immunohistochemical staining of HO-1 was intensified in HO-1 Tg compared to the NTg myocardium. Thus, the HO-1 Tg mouse model suggests a valuable therapeutic approach in the treatment of ischemic myocardium...
  23. pmc Lentiviral-human heme oxygenase targeting endothelium improved vascular function in angiotensin II animal model of hypertension
    Jian Cao
    Department of Physiology and Pharmacology, The University of Toledo, Toledo, OH 43614, USA
    Hum Gene Ther 22:271-82. 2011
    ....
  24. doi Heme oxygenase-1 mediates the protective effects of ischemic preconditioning on mitigating lung injury induced by lower limb ischemia-reperfusion in rats
    Tsui Chin Peng
    Department of Anesthesiology, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan
    J Surg Res 167:e245-53. 2011
    ..Ischemic preconditioning (IP), a process of transient I/R, mitigates the acute lung injury induced by I/R. We sought to elucidate whether the protective effects of IP involve heme oxygenase-1 (HO-1)...
  25. doi Ischemic postconditioning attenuates lung reperfusion injury and reduces systemic proinflammatory cytokine release via heme oxygenase 1
    Bo Xu
    Department of Respiratory Medicine, Beijing Friendship Hospital Affiliated to the Capital University of Medical Sciences, Beijing, China
    J Surg Res 166:e157-64. 2011
    ..We have shown that IPO can attenuate lung IRI by up-regulating the protein expression of heme oxygenase-1(HO-1). This study tested the hypothesis that IPO attenuates systemic inflammatory responses following lung IRI by activating HO-1...
  26. doi Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses
    Yen Mei Lee
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    J Ethnopharmacol 135:179-85. 2011
    ..To evaluate the protective effect of baicalein on myocardial dysfunction caused by endotoxaemia in rats and to explore the possible mechanisms...
  27. pmc Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against non-steroidal anti-inflammatory drug-induced mitochondrial oxidative stress, apoptosis, and gastric mucosal injury
    Samik Bindu
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India
    J Biol Chem 286:39387-402. 2011
    ..Thus, induction and mitochondrial localization of HO-1 are a novel cytoprotective mechanism against MOS-mediated apoptotic tissue injury...
  28. doi 2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction
    Jeong Seok Hwa
    Department of Urology, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea
    J Ethnopharmacol 139:605-15. 2012
    ..Cinnamomum cassia Blume has been used as a traditional Chinese herbal medicine for alleviation of fever, inflammation, chronic bronchitis, and to improve blood circulation...
  29. doi Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1
    Siyu Chen
    Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences, Nanjing Normal University, Nanjing 210046, China
    Food Chem Toxicol 50:3025-31. 2012
    ..These results suggest that naringenin may serve as a novel drug in the treatment of these pathologies by inducing HO-1 expression/activity and subsequently decreasing VSMC proliferation and migration...
  30. ncbi Overexpression of heme oxygenase-1 protects smooth muscle cells against oxidative injury and inhibits cell proliferation
    Min Zhang
    Institute of Sports Medicine, The Third Hospital, Peking University, Beijing, China
    Cell Res 12:123-32. 2002
    ....
  31. doi EP2 receptor activation by prostaglandin E2 leads to induction of HO-1 via PKA and PI3K pathways in C6 cells
    Min Kyu Park
    Department of Pharmacology, School of Medicine and Institute of Health Sciences, Gyeongsang National University, 92 Chilam dong, Jinju 660 751, Republic of Korea
    Biochem Biophys Res Commun 379:1043-7. 2009
    ..The induction of HO-1 along with increase of p-Bad by PGE(2) is responsible for anti-apoptosis against oxidant stress...
  32. doi Association of neonatal hypoxia with lasting changes in left ventricular gene expression: an animal model
    Danny Del Duca
    Division of Cardiovascular Surgery, Montreal Children s Hospital McGill University Health Centre, Montreal, Quebec, Canada
    J Thorac Cardiovasc Surg 138:538-46, 546.e1. 2009
    ..We hypothesized that hypoxemia in early life causes lasting changes in gene expression in the developing heart and that such changes may persist into later life, affecting the physiology of the adult myocardium...
  33. doi Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of hemeoxygenase-1 and NQO1 expression
    Jin Sun Park
    Department of Molecular Medicine and Tissue Injury Defense Research Center, Ewha Womans University Medical School, Seoul, Korea
    J Neurochem 119:909-19. 2011
    ..Our data collectively suggest that HO-1 and NQO1 play a critical role in antioxidant effects of isoflavone metabolites in rat brain astrocytes...
  34. doi Cerebral hemorrhage, brain edema, and heme oxygenase-1 expression after experimental traumatic brain injury
    Shuichi Okubo
    Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Acta Neurochir Suppl 118:83-7. 2013
    ..05). These results suggest that cerebral hematomas might play a role in brain injury after TBI. Future studies should determine the role of iron released from the cerebral hematoma in TBI...
  35. pmc Protective effect of hypercapnic acidosis in ischemia-reperfusion lung injury is attributable to upregulation of heme oxygenase-1
    Shu Yu Wu
    Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan
    PLoS ONE 8:e74742. 2013
    ..In conclusion, the protective effect of HCA in IR lung injury in rats was mediated in part by the anti-inflammatory and anti-apoptotic action of HO-1. ..
  36. ncbi cDNA microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles
    Eiko Koike
    Department of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Toxicol Sci 67:241-6. 2002
    ..Our results suggest that cDNA microarray analysis is a useful tool to investigate the biological responses to pulmonary toxicants...
  37. ncbi Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome
    Ethan P Carter
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262 USA
    Am J Physiol Lung Cell Mol Physiol 283:L346-53. 2002
    ..These data provide in vivo evidence for the NO-mediated upregulation of HO-1 expression and support the concept that hepatopulmonary syndrome is multifactorial, involving not only NO, but also HO-1 and CO...
  38. ncbi Immunocytochemical localization and expression of heme oxygenase-1 in primary astroglial cell cultures during differentiation: effect of glutamate
    Giovanni Li Volti
    Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Italy
    Biochem Biophys Res Commun 315:517-24. 2004
    ..Our results demonstrate that changes in HO-1 protein expression and localization in primary cultured astroglial cells may be part of the underlying mechanisms involved in brain development as well as in neurodegenerative diseases...
  39. ncbi Peroxynitrite induces HO-1 expression via PI3K/Akt-dependent activation of NF-E2-related factor 2 in PC12 cells
    Mei Hua Li
    National Research Laboratory, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Free Radic Biol Med 41:1079-91. 2006
    ..The SIN-1-induced HO-1 upregulation may confer the adaptive survival response against nitrosative stress...
  40. ncbi A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells
    Dominique Chabannes
    Institut National de la Sante et de la Recherche Medicale INSERM, U643, Nantes, France
    Blood 110:3691-4. 2007
    ..In conclusion, we show, for the first time, that HO-1 mediates the immunosuppressive properties of rat and human MSCs...
  41. doi Possible relation of hemin-induced HO-1 expression to the upregulation of VEGF and BDNF mRNA levels in rat C6 glioma cells
    Kyoji Morita
    Laboratory of Neuropharmacology, Department of Nursing, Shikoku University School of Health Sciences, Ohjin, Tokushima, 771 1192, Japan
    J Mol Neurosci 38:31-40. 2009
    ....
  42. pmc Heme oxygenase-1 inhibits pro-oxidant induced hypertrophy in HL-1 cardiomyocytes
    Keith R Brunt
    Department of Physiology, Queen s University, 431 Botterell Hall, Kingston, Ontario K7L 3N6, Canada
    Exp Biol Med (Maywood) 234:582-94. 2009
    ..Reactive oxygen species (ROS) activate multiple signaling pathways involved in cardiac hypertrophy. Since HO-1 exerts potent antioxidant effects, we hypothesized that this enzyme inhibits ROS-induced cardiomyocyte hypertrophy...
  43. ncbi Upregulation of heme oxygenase-1 in an animal model of Takotsubo cardiomyopathy
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University School of Medicine, Wakayama, Japan
    Circ J 73:1141-6. 2009
    ..Disturbance of the coronary microcirculation and catecholamine intoxication, which may be responsible for the pathogenesis of takotsubo cardiomyopathy, could trigger an oxidative stress response in the heart...
  44. doi Induction of heme oxygenase-1 with hemin attenuates hippocampal injury in rats after acute carbon monoxide poisoning
    Li Guan
    Research Center of Occupational Medicine, Peking University Third Hospital, Beijing, China
    Toxicology 262:146-52. 2009
    ..Though the precise mechanisms underlying hemin-mediated HO-1 induction and neuroprotection are not known, these may involve the anti-oxidant and anti-apoptotic effects of HO-1 enzyme activity...
  45. ncbi Role of heme oxygenase-1 in protection of the kidney after hemorrhagic shock
    Yutaka Arimori
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700 8558, Japan
    Int J Mol Med 26:27-32. 2010
    ....
  46. pmc Inhibition of cytochrome P450 1A2-mediated metabolism and production of reactive oxygen species by heme oxygenase-1 in rat liver microsomes
    James R Reed
    Department of Pharmacology and The Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    Drug Metab Lett 5:6-16. 2011
    ....
  47. ncbi [The role of endogenous carbon monoxide in vascular remodeling in hypoxic pulmonary hypertension]
    Guo hua Zhen
    Institue of Respiratory Disease, Tongji Hospital, Tongji Medical University, Wuban Hubei 430030, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 18:374-7. 2002
    ....
  48. ncbi [Genistein attenuates monocrotaline-induced pulmonary arterial hypertension in rats by up-regulating heme oxygenase-1 expression]
    Yukun Zhang
    Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Nan Fang Yi Ke Da Xue Xue Bao 32:151-4. 2012
    ..To study the effect of genistein on the expression of heme oxygenase-1 (HO-1) in rats with pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT)...
  49. pmc Brain death induces renal expression of heme oxygenase-1 and heat shock protein 70
    Leon F A van Dullemen
    Department of Surgery, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    J Transl Med 11:22. 2013
    ..We studied the role of stress-inducible genes Heme Oxygenase-1 (HO-1), HSP27, HSP40, and HSP70 in the kidney following a 4 hour period of brain death...
  50. doi The therapeutic effect of vascular endothelial growth factor gene- or heme oxygenase-1 gene-modified endothelial progenitor cells on neovascularization of rat hindlimb ischemia model
    Jianting Long
    Department of Vascular Surgery, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong, China
    J Vasc Surg 58:756-65.e2. 2013
    ..To explore the therapeutic potential of endothelial progenitor cells (EPCs) transfected with vascular endothelial growth factor A (VEGFA) and heme oxygenase-1 (HO-1) on rat hindlimb ischemia model...
  51. doi Heme oxygenase-1 induction by the ROS-JNK pathway plays a role in aluminum-induced anemia
    Chia Yeh Lin
    Ph D Program in Nutrition and Food Science, Fu Jen Catholic University, Hsinchuang, New Taipei City, Taiwan
    J Inorg Biochem 128:221-8. 2013
    ..Thus, Al enhances HO-1 expression through the ROS-JNK pathway, which may enhance HO activity and accelerate degradation of heme, leading to hypochromic anemia...
  52. doi Impaired autophagy contributes to hepatocellular damage during ischemia/reperfusion: heme oxygenase-1 as a possible regulator
    Nari Yun
    School of Pharmacy, Sungkyunkwan University, 300 Cheoncheon dong, Jangan gu, Suwon, Gyeonggi do 440 746, Republic of Korea
    Free Radic Biol Med 68:168-77. 2014
    ....
  53. doi Heme Oxygenase Improves Renal Function by Potentiating Podocyte-Associated Proteins in Nω-Nitro-l-Arginine-Methyl Ester (l-NAME)-Induced Hypertension
    Joseph Fomusi Ndisang
    Department of Physiology, University of Saskatchewan College of Medicine, Saskatoon, SK, Canada S7N 5E5
    Am J Hypertens 28:930-42. 2015
    ....
  54. pmc IL-10/HMOX1 signaling modulates cochlear inflammation via negative regulation of MCP-1/CCL2 expression in cochlear fibrocytes
    Jeong Im Woo
    Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095
    J Immunol 194:3953-61. 2015
    ..involved in cochlear protection from inflammation-mediated tissue damage, focusing on IL-10 and hemoxygenase-1 (HMOX1) signaling...
  55. pmc Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats
    Qing Ying Chen
    Medical Department, General Hospital of Jinan Military Command, 25 Shifan Road, Jinan, Shandong 250031, China
    J Diabetes Res 2016:9726503. 2016
    ..Furthermore, HO-1 increased the levels of VEGF and ICAM-1 and expressions of CBS and CSE protein. In summary, HO-1 promoted the wound closure by augmenting anti-inflammation, antioxidant, and angiogenesis in diabetic rats. ..
  56. pmc Protective effect of Xuebijing injection on D-galactosamine- and lipopolysaccharide-induced acute liver injury in rats through the regulation of p38 MAPK, MMP-9 and HO-1 expression by increasing TIPE2 expression
    Ming Wei Liu
    Department of Emergency Medicine, the First Hospital Affiliated to Kunming Medical University, Kunming, Yunnan 650032, P R China
    Int J Mol Med 38:1419-1432. 2016
    ..The marked protective effects of XBJ suggest that it has the potential to be used in the treatment of LPS-induced liver injury...
  57. doi Involvement of the heme oxygenase-carbon monoxide-cGMP pathway in the nociception induced by acute painful stimulus in rats
    Priscila G Carvalho
    Psychobiology Post graduation Program, School of Philosophy, Science and Literature of Ribeirão Preto, University of Sao Paulo, Ribeirão Preto 14040 901, SP, Brazil
    Brain Res 1385:107-13. 2011
    ..c.v. treatment with ZnDPBG or ODQ did not alter the AI. Therefore, we provide evidence consistent with the notion that HO-CO-cGMP pathway plays a key phasic antinociceptive role modulating noninflammatory acute pain...
  58. doi Melatonin inhibits type 1 interferon signaling of toll-like receptor 4 via heme oxygenase-1 induction in hepatic ischemia/reperfusion
    Jung Woo Kang
    School of Pharmacy, Sungkyunkwan University, Suwon, Korea
    J Pineal Res 53:67-76. 2012
    ..Our findings suggest that melatonin protects the liver against I/R injury by HO-1 overexpression, which suppresses the type 1 IFN signaling pathway downstream of TLR4...
  59. doi Up-regulation of heme oxygenase-1 attenuates brain damage after cerebral ischemia via simultaneous inhibition of superoxide production and preservation of NO bioavailability
    Xiaodong D Chao
    The Department of Neurosurgery, Xinjiang Military General Hospital, Urumqi, 830000, China
    Exp Neurol 239:163-9. 2013
    ..Together, our results suggest that Ad-HO-1 attenuates post-ischemic brain damage via simultaneous reduction of oxidative/nitrative stress and preservation of NO bioavailability...
  60. doi Postconditioning with far-infrared irradiation increases heme oxygenase-1 expression and protects against ischemia/reperfusion injury in rat testis
    Yuan Po Tu
    Department of Urology, Tao Yuan General Hospital, Department of Health, Taoyuan 330, Taiwan
    Life Sci 92:35-41. 2013
    ..We used a far-infrared radiation (FIR) heater to investigate the postconditioning protective role of HO-1 against ischemia/reperfusion (I/R) injury in rat testis...
  61. pmc Desipramine protects neuronal cell death and induces heme oxygenase-1 expression in Mes23.5 dopaminergic neurons
    Hsiao Yun Lin
    Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan
    PLoS ONE 7:e50138. 2012
    ..It has also been used in a number of other psychiatric and medical conditions. The present study is the first to investigate the neuroprotective effect of desipramine...
  62. doi Dietary α-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis
    Ayman Ibrahim
    Medicine University, Institute of Biomedical Research, Rouen, France
    Nutrition 28:799-802. 2012
    ..Therefore, we evaluated whether dietary ALA would decrease the expression of adhesion molecules by inducing the protective enzyme heme oxygenase-1 (HO-1) in a rat colitis model...
  63. doi [Effect of reduced glutathione on proliferation of rat hepatic stellate cells and the Nrf2/HO-1 signaling pathway]
    Li Zhang
    Department of Infectious Disease, The First Hospital of Shanxi Medical University, Taiyuan, China
    Zhonghua Gan Zang Bing Za Zhi 20:507-11. 2012
    ..To explore the effects of reduced glutathione (GSH) on the proliferation of hepatic stellate cells and the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway...
  64. ncbi Oxidant stress responses in influenza virus pneumonia: gene expression and transcription factor activation
    A M Choi
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Am J Physiol 271:L383-91. 1996
    ..Thus influenza pneumonia causes an oxidant stress response in the lungs, the nature of which is determined in part by the genetic background of the host...
  65. ncbi Gene transfection of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity
    Rio Hori
    Department of Biochemistry and Integrative Medical Biology, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 277:10712-8. 2002
    ..These results provided evidence that gene transfection of the activity-lacking mutant HO-1 protects cells against oxidative stress through multiple mechanisms involving up-regulation of catalase and glutathione contents...
  66. pmc Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress
    Nobuaki Ozawa
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan
    J Clin Invest 109:457-67. 2002
    ..Thus, Leydig cells appear to use HO-1-derived CO to trigger apoptosis of premeiotic germ cells and thereby modulate spermatogenesis under conditions of stress...
  67. ncbi Role of the haem oxygenase-carbon monoxide pathway in insulin-induced hypothermia: evidence for carbon monoxide involvement
    Camila Almeida
    Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, 14049 900, Brasil
    Pflugers Arch 444:244-50. 2002
    ....
  68. ncbi Selective regulation of blood pressure by heme oxygenase-1 in hypertension
    Joseph Fomusi Ndisang
    Department of Physiology, University of Saskatchewan, Saskatoon, Canada
    Hypertension 40:315-21. 2002
    ..The HO/CO-sGC/cGMP system appears normal in adult SHR, but desensitization of the downstream targets of the system to sGC/cGMP may endow SHR at this stage a persistent hypertension status...
  69. ncbi Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury
    Xuchen Zhang
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Lung Cell Mol Physiol 283:L815-29. 2002
    ..Together, our data show that I-R not only induces HO-1 gene expression in mouse lungs and vascular cells but that gene transcription occurs via the promoter and E1 enhancer and involves upstream MAPK pathways...
  70. ncbi Expression of heme oxygenase-1 in response to myocardial infarction in rats
    Päivi Lakkisto
    Department of Clinical Chemistry, University of Turku, Turku, Finland
    J Mol Cell Cardiol 34:1357-65. 2002
    ..The results suggest that the induction of HO-1 may have an important role in the heart during the first days after myocardial infarction...
  71. ncbi Heme oxygenase inhibitor restores arteriolar nitric oxide function in dahl rats
    Fruzsina K Johnson
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Hypertension 41:149-55. 2003
    ..These results suggest that elevated levels of endogenous CO contribute to arteriolar NO dysfunction in DS rats with salt-induced hypertension...
  72. ncbi Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes
    Thomas Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Georg August Universitat Gottingen, D 37073 Gottingen, Germany
    J Biol Chem 278:17927-36. 2003
    ..Thus, the HO-1 CRE/AP-1 element mediates HO-1 gene induction via activation of JNK/c-Jun whereas p38 isoforms act through a different mechanism via the E-box...
  73. ncbi Expression of heme oxygenase-1 in rat ontogeny
    Takaoki Watanabe
    Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata, Japan
    Arch Histol Cytol 66:155-62. 2003
    ..HO-1 expression in non-macrophagic cells may be required for other purposes such as protection from oxidative stress and various stimuli...
  74. ncbi Haeme-oxygenase 1 expression in rat pancreatic beta cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP
    J C Jonas
    Unit of Endocrinology and Metabolism, Faculty of Medicine, University of Louvain, Brussels, Belgium corrected
    Diabetologia 46:1234-44. 2003
    Increased expression of haeme-oxygenase 1 (HO1) and other antioxidant enzymes could improve pancreatic beta-cell survival under stressful conditions, including hyperglycaemia...
  75. ncbi Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling
    Shaw Fang Yet
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    FASEB J 17:1759-61. 2003
    ..VSMC isolated from HO-1-/- mice were susceptible to oxidant stress, leading to cell death. Our data demonstrate that HO-1 plays an essential protective role in the pathophysiology of atherosclerosis and vein graft stenosis...
  76. ncbi Right ventricle of patients undergoing congenital cardiac surgery differentially expresses haem oxygenase-1 and heat shock protein 70 genes
    M Takeuchi
    Department of Anaesthesiology and Resuscitology, Okayama University Medical School, Japan
    J Int Med Res 31:413-7. 2003
    ..Levels of HO-1 and HSP70 mRNA were significantly increased in all specimens, but the orders of magnitude of the increases were different, suggesting that the genes expressing HO-1 and HSP70 are regulated separately...
  77. ncbi Heme oxygenase induction protects liver against oxidative stress in x-irradiated aged rats
    Serdar Oztezcan
    Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Capa, Istanbul, Turkey
    Biogerontology 5:99-105. 2004
    ..These results suggest that the additional oxidative stress produced in irradiated rats may be compensated by HO-1 induction as decreased lipid peroxide levels were shown in the livers of aged animals...
  78. ncbi Mechanism of heme oxygenase-1 gene induction by quercetin in rat aortic smooth muscle cells
    Hui Chen Lin
    Department of Ophthalmology, Shin Kong Wu Ho Su Memorial Hospital, Taipei Medical University, Taiwan
    Pharmacology 71:107-12. 2004
    ..The level of quercetin-induced HO-1 expression was attenuated by SB202190 (a p38MAPK inhibitor). Taken together from the data in this study, we suggest that quercetin induced HO-1 expression, at least in part, through p38MAPK...
  79. ncbi Cardioprotective and vasomotor effects of HO activity during acute and chronic hypoxia
    Cynthia L Hartsfield
    Div of Pulmonary Sciences and Critical Care Medicine, Univ of Colorado Health Sciences Center, 4200 East Ninth Ave, B 133, Denver, CO 80262, USA
    Am J Physiol Heart Circ Physiol 287:H2009-15. 2004
    ....
  80. ncbi Exogenous metalloporphyrins alter the organization and function of cultured neonatal rat heart cells via modulation of heme oxygenase activity
    Robert Akins
    Department of Biomedical Research, A I duPont Hospital for Children, Wilmington, Delaware, USA
    J Cell Physiol 201:26-34. 2004
    ..These results suggest that heme and its catabolites act to modulate aspects of cardiac cell function and organization...
  81. ncbi Role of NF-kappaB and p38 MAP kinase signaling pathways in the lipopolysaccharide-dependent activation of heme oxygenase-1 gene expression
    Nastiti Wijayanti
    Institut fur Klinische Chemie und Pathobiochemie, Justus Liebig Universitat Giessen, D 35392 Giessen, Germany
    Antioxid Redox Signal 6:802-10. 2004
    ..The results suggest that the NF-kappaB and p38 MAPK signaling pathways mediate the LPS-dependent induction of HO-1 gene expression via DNA sequences of the proximal promoter region...
  82. ncbi Induction of heme oxygenase-1 is involved in anti-proliferative effects of paclitaxel on rat vascular smooth muscle cells
    Byung Min Choi
    Genomic Research Center for Immune Disorders, Wonkwang University, Iksan, Chonbuk, Republic of Korea
    Biochem Biophys Res Commun 321:132-7. 2004
    ..These results demonstrated that paclitaxel induces the expression of HO-1 via the JNK pathway in VSMC and that HO-1 expression might be responsible for the anti-proliferative effect of paclitaxel on VSMC...
  83. ncbi Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survival
    Xiao ming Liu
    Houston Veterans Affairs Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 280:872-7. 2005
    ..The capacity of ER stress to stimulate the HO-1/CO system provides a novel mechanism by which this organelle regulates cell survival...
  84. ncbi Extracellular acidosis induces heme oxygenase-1 expression in vascular smooth muscle cells
    Helen Christou
    Div of Newborn Medicine, Children s Hospital, 300 Longwood Ave, Enders 9, Boston, MA 02115, USA
    Am J Physiol Heart Circ Physiol 288:H2647-52. 2005
    ..We speculate that EA, as an important tissue and cellular stressor for VSMCs, may elicit changes in gene expression patterns that contribute to the maintenance or disruption of vascular homeostasis...
  85. ncbi Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism
    Akiko Kikuchi
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Hum Genet 116:354-60. 2005
    ..A (GT)(n) dinucleotide repeat in the 5'-flanking region of the human HO-1 gene (alias HMOX1) reduces HO-1 inducibility and shows length polymorphism, which is grouped into three classes: class S (<27 GT),..
  86. ncbi Thymidine phosphorylase gene transfer inhibits vascular smooth muscle cell proliferation by upregulating heme oxygenase-1 and p27KIP1
    Wei Li
    Second Department of Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Arterioscler Thromb Vasc Biol 25:1370-5. 2005
    ..However, its effect on vascular smooth muscle cells (VSMCs) is poorly understood. In this study, we examined the effect of TP on VSMCs in vitro and in vivo...
  87. ncbi Propofol inhibits caspase-3 in astroglial cells: role of heme oxygenase-1
    Rosaria Acquaviva
    Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, Italy
    Curr Neurovasc Res 2:141-8. 2005
    ..These findings indicate that propofol attenuates peroxynitrite-mediated apoptosis in astroglial cells, a property that may be relevant in both physiological and pathological processes in the CNS...
  88. ncbi [The regulation of carbon monoxide/heme oxygenase system by hydrogen sulfide in rats with hypoxic pulmonary hypertension]
    Qing you Zhang
    Department of Pediatrics, First Hospital, Peking University, Beijing, China
    Zhonghua Jie He He Hu Xi Za Zhi 27:659-63. 2004
    ..To explore the impact of hydrogen sulfide (H2S) on the carbon monoxide (CO)/heme oxygenase-1 (HO-1) system in pulmonary artery of hypoxic rats...
  89. ncbi Complementary regulation of heme oxygenase-1 and peroxiredoxin I gene expression by oxidative stress in the liver
    S Immenschuh
    Institute for Clinical Immunology und Transfusion Medicine, University of Giessen Langhansstr 7, 35392 Giessen, Germany
    Cell Mol Biol (Noisy-le-grand) 51:471-7. 2005
    ..Taken together, the complementary hepatic gene expression pattern of HO-1 and Prx I in response to oxidative stress may suggest a functional interplay of these antioxidant genes...
  90. ncbi Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels
    L E Fredenburgh
    Division of Pulmonary and Critical Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Biol (Noisy-le-grand) 51:513-20. 2005
    ..These findings have implications for our understanding of the pathophysiology of ARDS and may guide future therapeutic strategies...
  91. pmc Association of susceptibility to the development of pneumonia in the older Japanese population with haem oxygenase-1 gene promoter polymorphism
    H Yasuda
    J Med Genet 43:e17. 2006
    ....
  92. ncbi Differential nephron HO-1 expression following glomerular epithelial cell injury
    Prasun K Datta
    Laboratory of AIDS Pathogenesis and Molecular Therapeutics, Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA 19122, USA
    Nephron Exp Nephrol 103:e131-8. 2006
    ..In this model, we assessed nephron distribution of the expression of the inducible HO isoform, HO-1, and the role of free radicals in modulating HO-1 expression...
  93. ncbi Renal upregulation of HO-1 reduces albumin-driven MCP-1 production: implications for chronic kidney disease
    Narayana S Murali
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 292:F837-44. 2007
    ..These findings suggest that the induction of HO-1 in the proximal tubule, as occurs in chronic kidney disease, may be a countervailing response that reduces albumin-stimulated production of cytokines such as MCP-1...
  94. ncbi Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells
    Hyun Ock Pae
    Medicinal Resources Research Institute, Department of Microbiology and Immunology, Wonkwang University, Iksan 570 749, Korea
    Exp Mol Med 39:267-77. 2007
    ....
  95. ncbi Subcellular location of heme oxygenase 1 and 2 and divalent metal transporter 1 in relation to endocytotic markers during heme iron absorption
    Adrian R West
    School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Australia
    J Gastroenterol Hepatol 23:150-8. 2008
    ..Currently, the location of HO-1 and HO-2 in enterocytes is unknown...
  96. ncbi Effect of heme oxygenase-1 induction by octreotide on TNBS-induced colitis
    Yesim Erbil
    Department of General Surgery, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
    J Gastroenterol Hepatol 22:1852-8. 2007
    ..The aim of the present study was to investigate whether heme oxygenase-1 (HO-1) induction by octreotide could protect against oxidative and inflammatory damage from induced colitis...
  97. ncbi [Effect of heme oxygenase on apoptosis and apoptosis genes in hepatic ischemia reperfusion injury in rats]
    Yang Yang Wang
    Department of Gastroenterology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
    Zhonghua Gan Zang Bing Za Zhi 15:922-5. 2007
    ..To use heme oxygenase (HO) inducer hemin and a HO inhibitor zinc protoporphyrin (ZnPP) to investigate the effect of HO on apoptosis and apoptosis genes in hepatic ischemia reperfusion (IR) injury in rats...
  98. doi Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 10:1767-812. 2008
    ....
  99. pmc Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans
    Abdelhamid Almolki
    INSERM U700, Universite Paris 7, Paris, France
    Am J Pathol 173:981-92. 2008
    ..7% versus 8.6%, P = 0.047). No such results were observed in those who had never smoked (n = 297). We conclude that HO-1 has a significant protective effect against airway mucus hypersecretion in animals and humans exposed to CS...
  100. doi Carbon monoxide produced by intrasinusoidally located haem-oxygenase-1 regulates the vascular tone in cirrhotic rat liver
    Lien Van Landeghem
    Department of Hepatology, University Hospital Gasthuisberg, KU Leuven, Belgium
    Liver Int 29:650-60. 2009
    ..We aimed to elucidate the vasoregulatory role of CO in the microcirculation in normal and thioacetamide cirrhotic rat livers...
  101. pmc Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway
    Pedro Geraldes
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    J Biol Chem 283:34327-36. 2008
    b>Heme oxygenase 1 (HO-1) is a representative mediator of antioxidants and cytoprotectants against various stress stimuli including oxidants in vascular cells...

Research Grants5

  1. Karl A Nath; Fiscal Year: 2016
    ..Our proposed application thus continues to pursue the functionality of HO-1, as it utilized a new strategy, transgenic mice, and as it defines a new area of involvement namely, renal inflammation. ..
  2. Regulation of Vascular Tone During Cirrhosis
    ETHAN CARTER; Fiscal Year: 2003
    ..This project will not only define the cellular basis for hepatopulmonary syndrome, but will also contribute to our understanding of how pulmonary vascular tone is controlled at the most basic level. ..
  3. Regulation of Pulmonary Vascular Tone During Cirrhosis
    CHRYSTELLE GARAT CARTER; Fiscal Year: 2004
    ..This project will not only define the cellular basis for hepatopulmonary syndrome, but will also contribute to our understanding of how pulmonary vascular tone is controlled at the most basic level. ..
  4. Role of Cysteine-rich Protein 2 in Vascular Disease
    Shaw Fang Yet; Fiscal Year: 2005
    ..abstract_text> ..
  5. Development of neuromuscular junctions in children with cerebral palsy
    Robert Akins; Fiscal Year: 2008
    ..The PIs study these interactions in order to develop therapies and treatments that will improve and sustain the physical ability and health of patients with CP. [unreadable] [unreadable] [unreadable]..