Hmgb1

Summary

Gene Symbol: Hmgb1
Description: high mobility group box 1
Alias: Ac2-008, Hmg1, HMG-1, amphoterin, heparin-binding protein p30, high mobility group 1, high mobility group protein 1, high mobility group protein B1
Species: rat

Top Publications

  1. ncbi The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system
    O Hori
    Department of Physiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 270:25752-61. 1995
  2. doi Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Oita, Japan
    Crit Care Med 36:2407-13. 2008
  3. doi Intraocular expression and release of high-mobility group box 1 protein in retinal detachment
    Noboru Arimura
    Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Lab Invest 89:278-89. 2009
  4. ncbi Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    Paola Scaffidi
    DIBIT, Istituto Scientifico San Raffaele, 20132 Milano, Italy
    Nature 418:191-5. 2002
  5. ncbi High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity
    Kazuyuki Takata
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    J Neurosci Res 78:880-91. 2004
  6. ncbi Induction and subcellular localization of high-mobility group box-1 (HMGB1) in the postischemic rat brain
    Jung Bin Kim
    Department of Anatomy and Center for Advanced Medical Education BK21 project, Inha University School of Medicine, Inchon, Korea
    J Neurosci Res 86:1125-31. 2008
  7. doi Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 34:402-6. 2010
  8. pmc Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1
    Sarah A Steer
    The Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri, USA
    PLoS Med 3:e17. 2006
  9. doi Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart
    Kunihiko Takahashi
    Translational Cardiovascular Therapeutics, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK
    Circulation 118:S106-14. 2008
  10. doi Spinal high-mobility group box 1 contributes to mechanical allodynia in a rat model of bone cancer pain
    Wei Tong
    Department of Out Patient, Xijing Hospital, Fourth Military Medical University, Xi an 710032, PR China
    Biochem Biophys Res Commun 395:572-6. 2010

Scientific Experts

  • Satoshi Hagiwara
  • Anthony J Bell
  • Yi Ming Shao
  • Runkuan Yang
  • Hui Ming Gao
  • Mitsuya Watanabe
  • Guo Min Li
  • Ken ichi Otoshi
  • Zhong Fu Zhao
  • M Stros
  • Ping Li
  • Marc G Jeschke
  • G Hoppe
  • Hiroki Kuniyasu
  • Bernard Degryse
  • I Grigorov
  • Yong ming Yao
  • Iva Ugrinova
  • Li Feng Huang
  • Li Tian Zhang
  • Iliya G Pashev
  • Zhi yong Sheng
  • Evdokia Pasheva
  • Marco E Bianchi
  • Ikuro Maruyama
  • Ko ichi Kawahara
  • Petar Pelovsky
  • Ning Dong
  • Jung Bin Kim
  • R Kokkola
  • Yan Yu
  • Francesca Riuzzi
  • Safa Lotfi
  • Xiangqian Kong
  • Kazuhide Hayakawa
  • Guglielmo Sorci
  • Ying Yu
  • Hui Juan He
  • Noureddine Loukili
  • Hui Fang Guo
  • Ke Bing Chen
  • Junghyun Kim
  • Anding Liu
  • Wen Song Ge
  • Ivan Elenkov
  • Tuanzhu Ha
  • Ya xin Yin
  • H Christian Volz
  • Yoko Oyama
  • Wei Tong
  • Hideyuki Kawabata
  • Il Doo Kim
  • Masayuki Shibasaki
  • Lina Wang
  • Paola Scaffidi
  • Kamal K Biswas
  • Teruto Hashiguchi
  • Li chao Hou
  • Yan Bo Wang
  • Chae Moon Lim
  • Hulda Sigridur Hreggvidsdottir
  • Noboru Arimura
  • Qiang Wang
  • Takashi Kohno
  • Ja Kyeong Lee
  • Evdokia A Pasheva
  • Yingkai Feng
  • K Y Chung
  • Y H Kao
  • Madhuri Pahuja
  • Dessislava Topalova
  • Asa Andersson
  • Kunihiko Takahashi
  • Jieping Yang
  • R Sugars
  • Keyue Liu
  • Joseph P Bidwell
  • Matthew Watson
  • Micah J McCauley
  • Alexander G Robling
  • Rita Shah
  • Kanokwan Charoonpatrapong
  • Cecilia K Zetterström
  • Sarah A Steer
  • Alessandra Agresti
  • Rosario Donato
  • Yan Dai
  • Evo K Lindersson
  • Roberta Palumbo
  • Kazuyuki Takata

Detail Information

Publications89

  1. ncbi The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system
    O Hori
    Department of Physiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 270:25752-61. 1995
    ..NH2-terminal and internal protein sequence data for p23 matched that reported previously for amphoterin. Amphoterin purified from rat brain or recombinant rat amphoterin bound to purified sRAGE in a saturable and ..
  2. doi Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Oita, Japan
    Crit Care Med 36:2407-13. 2008
    ..High mobility group box 1 (HMGB1) protein has been shown to play a key role as a significant factor in sepsis pathogenesis...
  3. doi Intraocular expression and release of high-mobility group box 1 protein in retinal detachment
    Noboru Arimura
    Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Lab Invest 89:278-89. 2009
    High-mobility group box 1 (HMGB1) protein is a multifunctional protein, which is mainly present in the nucleus and is released extracellularly by dying cells and/or activated immune cells...
  4. ncbi Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    Paola Scaffidi
    DIBIT, Istituto Scientifico San Raffaele, 20132 Milano, Italy
    Nature 418:191-5. 2002
    b>High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets...
  5. ncbi High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity
    Kazuyuki Takata
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    J Neurosci Res 78:880-91. 2004
    ..High mobility group box protein-1 (HMGB1) is an abundant nonhistone chromosomal protein...
  6. ncbi Induction and subcellular localization of high-mobility group box-1 (HMGB1) in the postischemic rat brain
    Jung Bin Kim
    Department of Anatomy and Center for Advanced Medical Education BK21 project, Inha University School of Medicine, Inchon, Korea
    J Neurosci Res 86:1125-31. 2008
    High-mobility group box-1 (HMGB1) was originally identified as a ubiquitously expressed, abundant nonhistone DNA-binding protein...
  7. doi Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 34:402-6. 2010
    ..Serum concentrations of cytokines (IL-1β, IL-6, and TNF-α), NO, and high-mobility group box 1 (HMGB1) protein were measured at various time points after treatment...
  8. pmc Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1
    Sarah A Steer
    The Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri, USA
    PLoS Med 3:e17. 2006
    ..IL-1, known to inhibit glucose-induced insulin secretion by stimulating inducible nitric oxide synthase expression and increased production of nitric oxide by beta-cells, also induces beta-cell death...
  9. doi Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart
    Kunihiko Takahashi
    Translational Cardiovascular Therapeutics, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK
    Circulation 118:S106-14. 2008
    ..High-mobility group box 1 (HMGB1) is a nuclear protein, which has recently been uncovered to also act as a modifier of inflammation when released...
  10. doi Spinal high-mobility group box 1 contributes to mechanical allodynia in a rat model of bone cancer pain
    Wei Tong
    Department of Out Patient, Xijing Hospital, Fourth Military Medical University, Xi an 710032, PR China
    Biochem Biophys Res Commun 395:572-6. 2010
    ..Being first reported as a nonhistone chromosomal protein, high-mobility group box 1 (HMGB1) is now implicated as a mediator of inflammation...
  11. doi Bile high-mobility group box 1 contributes to gut barrier dysfunction in experimental endotoxemia
    Runkuan Yang
    Dept of Critical Care Medicine, Univ of Pittsburgh Medical School, 1055 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Regul Integr Comp Physiol 297:R362-9. 2009
    ..cells and extrahepatic macrophages release a large amount of the inflammatory cytokine high-mobility group box 1 (HMGB1) into the bile and that bile containing HMGB1 contributes to gut barrier dysfunction in experimental endotoxemia...
  12. ncbi The significance of changes in high mobility group-1 protein mRNA expression in rats after thermal injury
    Wen Hui Fang
    The Department of Microbiology and Immunology, Trauma Research Center, Postgraduate Medical College, Beijing, People s Republic of China
    Shock 17:329-33. 2002
    ..Up-regulation of HMG-1 expression may be involved in the pathogenesis of endogenous endotoxin-mediated multiple organ damage secondary to major burns...
  13. doi The effect of experimental diabetes on high mobility group box 1 protein expression in endotoxin-induced acute lung injury
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 168:111-8. 2011
    ..For instance, diabetes is associated with altered immune and hemostatic responses. High mobility group box 1 (HMGB1) protein plays a key role in various inflammatory diseases...
  14. doi Surgery upregulates high mobility group box-1 and disrupts the blood-brain barrier causing cognitive dysfunction in aged rats
    Hui Juan He
    Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China
    CNS Neurosci Ther 18:994-1002. 2012
    ..Herein, we sought to determine the relationship between cognitive decline, blood-brain barrier (BBB) permeability, and inflammation, namely high mobility group box-1 (HMGB1), after surgery in aged rats.
  15. doi Expression analysis of high mobility group box-1 protein (HMGB-1) in the cerebral cortex, hippocampus, and cerebellum of the congenital hydrocephalus (H-Tx) rat
    Mitsuya Watanabe
    Department of Neurosurgery, Juntendo University, Bunkyoku, Tokyo, Japan
    Acta Neurochir Suppl 113:91-6. 2012
    ..We expect that, in the future, regulating the expression or functions of HMGB-1 will lead to the possibility of impeding the progress of neuronal damage caused by hydrocephalus...
  16. doi The role of high-mobility group box-1 protein in the development of diabetic nephropathy
    Junghyun Kim
    Diabetic Complications Research Center, Division of Traditional Korean Medicine Integrated Research, Korea Institute of Oriental Medicine, Daejeon, South Korea
    Am J Nephrol 33:524-9. 2011
    The purpose of the experiment reported here was to assess the involvement of high-mobility group box-1 (HMGB1), receptor for advanced glycation end products (RAGE) and nuclear factor (NF)-κB signaling pathway in the development of rat ..
  17. doi [Effect of qinghuobaiduyin on the expression of high mobility group box chromosomal protein 1 in macrophage]
    Ping Li
    Department of Burn and Plastics Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:766-70. 2010
    To observe the expression of high mobility group box chromosomal protein 1(HMGB1) in RAW264...
  18. ncbi [The effect of simvastatin on the expression of high mobility group box-1 protein in atherosclerotic rats]
    Ya xin Yin
    First Affiliated Hospital of General Hospital of PLA, Beijing 100048, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:306-8. 2010
    To observe the effect of simvastatin on the expression of high mobility group box-1 protein (HMGB1) and morphology of atherosclerotic plaques in atherosclerotic rats, to ascertain whether HMGB1 plays a role in the preventive mechanism of ..
  19. pmc Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 109:7505-10. 2012
    ..reactive astrocytes can release a damage-associated molecular-pattern molecule called high-mobility-group-box-1 (HMGB1) that promotes endothelial progenitor cell (EPC)-mediated neurovascular remodeling during stroke recovery...
  20. doi The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats
    Li Feng Huang
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, People s Republic of China
    Shock 31:322-9. 2009
    The aim of the present study was to investigate in vivo the effect of high-mobility group box 1 protein (HMGB1) on activity of regulatory T cells (Tregs) and the influence on T-cell-mediated immunity after thermal injury...
  21. ncbi In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail
    Evdokia Pasheva
    Institute of Molecular Biology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Biochemistry 43:2935-40. 2004
    ..The alterations in the acetylation pattern of HMGB-1 and -2 upon removal of the C-terminal tail are regarded as a means by which the acidic domain modulates some properties of these proteins...
  22. doi Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling
    Takashi Kohno
    Cardiopulmonary Division, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cardiovasc Res 81:565-73. 2009
    High-mobility group box 1 protein (HMGB1) is one of the recently defined damage-associated molecular pattern molecules derived from necrotic cells and activated macrophages...
  23. doi High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis
    Hideyuki Kawabata
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    Spine (Phila Pa 1976) 35:1109-15. 2010
    ..culture and rat spinal cord injury (SCI) model were used to examine the expression of high mobility group box 1 (HMGB1), TNF-alpha, and Rage by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemical ..
  24. pmc High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy
    Yoko Oyama
    Department of Laboratory and Vascular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Lab Invest 90:853-66. 2010
    ..The DNA-binding high-mobility group box-1 protein (HMGB1) initiates and propagates inflammation when released by activated macrophages, and functions as an 'alarm cytokine'..
  25. ncbi Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats
    Keyue Liu
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    FASEB J 21:3904-16. 2007
    The high mobility group box-1 (HMGB1), originally identified as an architectural nuclear protein, exhibits an inflammatory cytokine-like activity in the extracellular space...
  26. ncbi Mapping intramolecular interactions between domains in HMGB1 using a tail-truncation approach
    Matthew Watson
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    J Mol Biol 374:1286-97. 2007
    The mechanism underlying negative regulation of HMGB1-DNA interaction by the acidic C-terminal tail is ill defined...
  27. ncbi Severity of sepsis is correlated with the elevation of serum high-mobility group box 1 in rats
    Li chao Hou
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Chin Med J (Engl) 122:449-54. 2009
    ..The late inflammatory cytokine, high-mobility group box 1 (HMGB1), plays a critical role in sepsis...
  28. ncbi The high mobility group box chromosomal protein 1 is expressed in the human and rat testis where it may function as an antibacterial factor
    Cecilia K Zetterström
    Department of Woman and Child Health, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Hum Reprod 21:2801-9. 2006
    The high mobility group box chromosomal protein 1 (HMGB1) was originally shown to be a nuclear DNA-binding protein that activates transcription and promotes differentiation...
  29. doi Induction of high mobility group box-1 in dorsal root ganglion contributes to pain hypersensitivity after peripheral nerve injury
    Masayuki Shibasaki
    Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Pain 149:514-21. 2010
    ..Blocking HMGB-1/RAGE signalling might thus be a promising therapeutic strategy for the management of neuropathic pain...
  30. ncbi RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages
    R Kokkola
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
    Scand J Immunol 61:1-9. 2005
    Abstract High-mobility group box chromosomal protein 1 (HMGB1) is a protein with both intranuclear functions and extracellular cytokine-like effects...
  31. pmc Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages
    Hiroki Kuniyasu
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    Am J Pathol 166:751-60. 2005
    High mobility group (HMGB)1/amphoterin is a multifunctional cytokine involved in invasion and metastasis of cancer and in inflammation...
  32. ncbi alpha-Synuclein filaments bind the transcriptional regulator HMGB-1
    Evo K Lindersson
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
    Neuroreport 15:2735-9. 2004
    ..We identified the transcriptional co-factor high mobility group protein 1 (HMGB-1) as a ligand for alpha-synuclein filaments by a filament spin-down technique, mass ..
  33. ncbi High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis
    R Kokkola
    Rheumatology Research Unit, Karolinska Hospital, Stockholm 171 76, Sweden
    Arthritis Rheum 46:2598-603. 2002
    ..Macrophages play pivotal roles in the pathogenesis of arthritis. The aim of this study was to determine whether synovial macrophage expression of HMGB-1 is altered in human and experimental synovitis...
  34. pmc The adhesive and neurite-promoting molecule p30: analysis of the amino-terminal sequence and production of antipeptide antibodies that detect p30 at the surface of neuroblastoma cells and of brain neurons
    H Rauvala
    Department of Medical Chemistry, University of Helsinki, Finland
    J Cell Biol 107:2293-305. 1988
    ..A model summarizing the suggested interactions of p30 in cell adhesion and neurite growth is presented...
  35. ncbi 30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane
    J Merenmies
    Department of Medical Chemistry, University of Helsinki, Finland
    J Biol Chem 266:16722-9. 1991
    ..cDNA and peptide sequencing identified a dipolar sequence that has been previously found in studies of high mobility group 1 protein: the 184-amino acid cationic region is followed by a cluster of 30 anionic residues...
  36. pmc Borna disease virus phosphoprotein binds a neurite outgrowth factor, amphoterin/HMG-1
    W Kamitani
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    J Virol 75:8742-51. 2001
    ..analysis of the purified 30-kDa protein revealed that its N terminus showed complete homology with rat amphoterin protein, which is a neurite outgrowth factor abundant in the brain during development...
  37. pmc The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells
    B Degryse
    Department of Genetics and Microbiology, University of Milan, 20133 Milan, Italy
    J Cell Biol 152:1197-206. 2001
    HMG1 (high mobility group 1) is a ubiquitous and abundant chromatin component. However, HMG1 can be secreted by activated macrophages and monocytes, and can act as a mediator of inflammation and endotoxic lethality...
  38. ncbi A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions
    M Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, CZ 612 65 Brno, Czech Republic
    J Biol Chem 275:35699-707. 2000
    ....
  39. ncbi Structure of the A-domain of HMG1 and its interaction with DNA as studied by heteronuclear three- and four-dimensional NMR spectroscopy
    C H Hardman
    Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, UK
    Biochemistry 34:16596-607. 1995
    b>HMG1 has two homologous, folded DNA-binding domains ("HMG boxes"), A and B, linked by a short basic region to an acidic C-terminal domain...
  40. doi Relationship between high-mobility group box 1 protein release and T-cell suppression in rats after thermal injury
    Li Tian Zhang
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, People s Republic of China
    Shock 30:449-55. 2008
    To study whether high-mobility group box 1 protein (HMGB1) has an effect on T-cell-mediated immunity secondary to burn injury, 96 male Wistar rats weighing 250 to 300 g were randomly divided into three groups as follows:sham burn group, ..
  41. doi High-mobility group box 1 protein activates hepatic stellate cells in vitro
    Y H Kao
    Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Transplant Proc 40:2704-5. 2008
    Our previous study noticed remarkably elevated titers of anti-high-mobility group box 1 (HMGB1) antibodies in sera during the tolerance induction phase of a rat tolerogenic orthotopic liver transplantation (OLT) as well as in sera of ..
  42. pmc Inhibition of high-mobility group box 1 expression by siRNA in rat hepatic stellate cells
    Wen Song Ge
    Department of Gastroenterology, Shanghai Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
    World J Gastroenterol 17:4090-8. 2011
    To explore the role of high-mobility group box 1 (HMGB1) protein during liver fibrogenesis and investigate the functional effects of HMGB1 gene silencing in hepatic stellate cells (HSCs) using siRNA.
  43. doi Heat shock transcription factor 1 inhibits H₂O₂-induced cardiomyocyte death through suppression of high-mobility group box 1
    Ying Yu
    Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai 200032, China
    Mol Cell Biochem 364:263-9. 2012
    ..In this study, we investigated the effects of HSF1-regulated HMGB1 on cardiomyocyte death...
  44. doi High-mobility-group box protein 1A box reduces development of sodium laurate-induced thromboangiitis obliterans in rats
    Xiangqian Kong
    Department of Vascular Surgery, Provincial Hospital affiliated to Shandong University, Ji Nan, China
    J Vasc Surg 57:194-204. 2013
    High-mobility-group box protein 1 (HMGB1), as a late mediator of inflammation, plays a key role in inflammatory responses by inducing and extending the production of proinflammatory cytokines...
  45. doi Evidence for the binding affinity of daunomycin to HMGB1 protein in chromatin and in solution
    Safa Lotfi
    Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Int J Biol Macromol 52:206-11. 2013
    In this study the interaction of daunomycin with HMGB1 nonhistone chromatin protein in the chromatin context using hydroxyapatite (HAP) column chromatography and free in solution was investigated employing fluorescence, circular ..
  46. doi High-mobility group box-1 and its receptors contribute to proinflammatory response in the acute phase of spinal cord injury in rats
    Ke Bing Chen
    Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Fukui, Japan
    Spine (Phila Pa 1976) 36:2122-9. 2011
    ..To examine the localization and expression of high-mobility group box-1 (HMGB-1) protein and its receptors after rat spinal cord injury...
  47. ncbi Phosphorylation of HMG-I by protein kinase C attenuates its binding affinity to the promoter regions of protein kinase C gamma and neurogranin/RC3 genes
    D M Xiao
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Neurochem 74:392-9. 2000
    ..The current results suggest that phosphorylation of the mammalian HMG-I by PKC alone or in combination with cdc2 kinase provides an effective mechanism for the regulation of HMG-I function...
  48. doi The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation
    Hulda Sigridur Hreggvidsdottir
    Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Karolinska Institutet, S 171 76 Stockholm, Sweden
    J Leukoc Biol 86:655-62. 2009
    The nuclear protein HMGB1 has previously been demonstrated to act as an alarmin and to promote inflammation upon extracellular release, yet its mode of action is still not well defined...
  49. doi Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia
    Lina Wang
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China
    Brain Res 1321:143-51. 2010
    Inflammatory damage plays an important role in cerebral ischemic pathogenesis. HMGB1-induced NF-kappaB activation pathway has been gaining recognition as a key contributor to the proinflammatory response...
  50. ncbi [Influence of splenic high mobility group box-1 protein on immune function of regulatory T lymphocytes in scald rats]
    Li Feng Huang
    Burns Institute, the First Hospital Affiliated to the PLA General Hospital, Beijing 100048, China
    Zhonghua Shao Shang Za Zhi 26:104-8. 2010
    To observe the influence of high mobility group box-1 protein (HMGB1) derived from spleen on the phenotype of regulatory T lymphocytes (Treg) and HMGB1-mediated immune function in severely scalded rats after delayed resuscitation.
  51. pmc Structure of the HMG box motif in the B-domain of HMG1
    H M Weir
    Department of Biochemistry, University of Cambridge, UK
    EMBO J 12:1311-9. 1993
    The conserved, abundant chromosomal protein HMG1 consists of two highly homologous, folded, basic DNA-binding domains, each of approximately 80 amino acid residues, and an acidic C-terminal tail...
  52. pmc Nucleotide sequence of rat liver HMG1 cDNA
    G Paonessa
    European Molecular Biology Laboratory, Heidelberg, FRG
    Nucleic Acids Res 15:9077. 1987
  53. doi HMGB1: the missing link between diabetes mellitus and heart failure
    H Christian Volz
    Department of Medicine III, University of Heidelberg, INF 410, 69120, Heidelberg, Germany
    Basic Res Cardiol 105:805-20. 2010
    ..glucose treatment of isolated cardiac fibroblasts, macrophages and cardiomyocytes led to a sustained induction of HMGB1 on the RNA and protein level followed by increased NF-κB binding activity with consecutively sustained TNF-α and ..
  54. doi High mobility group box 1 induces synoviocyte proliferation in rheumatoid arthritis by activating the signal transducer and activator transcription signal pathway
    Hui Fang Guo
    Department of Rheumatology, The Second Hospital of Hebei Medical University, Shijiazhuang, China
    Clin Exp Med 11:65-74. 2011
    Recently, it was discovered that high mobility group box chromosomal protein 1 (HMGB1) acts as a potent pro-inflammatory cytokine that is released into the extracellular milieu...
  55. pmc Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo
    Noureddine Loukili
    Department of Intensive Care Medicine, University Hospital Center and Faculty of Biology and Medicine, 1011 Lausanne, Switzerland
    Cardiovasc Res 89:586-94. 2011
    High-mobility group box 1 (HMGB1) is a nuclear protein actively secreted by immune cells and passively released by necrotic cells that initiates pro-inflammatory signalling through binding to the receptor for advance glycation end-..
  56. doi HMGB1 translocation and expression is caused by warm ischemia reperfusion injury, but not by partial hepatectomy in rats
    Anding Liu
    Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, Friedrich Schiller University Jena, Jena 07747, Germany
    Exp Mol Pathol 91:502-8. 2011
    Mechanical injury or ischemia/reperfusion (I/R) injury induces high mobility of group box 1 (HMGB1) translocation and release...
  57. pmc Glucan phosphate attenuates myocardial HMGB1 translocation in severe sepsis through inhibiting NF-κB activation
    Tuanzhu Ha
    Department of Surgery, East Tennessee State University, Johnson City, Tennessee 37614 0575, USA
    Am J Physiol Heart Circ Physiol 301:H848-55. 2011
    ..High-mobility group box 1 (HMGB1) serves as a late mediator of lethality in sepsis...
  58. pmc The DNA binding and bending activities of truncated tail-less HMGB1 protein are differentially affected by Lys-2 and Lys-81 residues and their acetylation
    Ivan Elenkov
    Institute of Moleculat Biology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Int J Biol Sci 7:691-9. 2011
    The role of lysines 2 and 81 as target sites for acetylation in full-length HMGB1 and truncated tail-less protein, respectively, has been studied by mutation analysis for the abilities of these proteins to bind and bend DNA...
  59. doi Antithrombin III prevents cerulein-induced acute pancreatitis in rats
    Satoshi Hagiwara
    Departments of Anesthesiology and Intensive Care Medicine, Oita University, Yufu City, Japan
    Pancreas 38:746-51. 2009
    Systemic inflammatory mediators, including the protein high-mobility group box 1 (HMGB1), play an important role in the development of acute pancreatitis...
  60. doi HMGB1 protein inhibits DNA replication in vitro: a role of the acetylation and the acidic tail
    Dessislava Topalova
    Institute of Molecular Biology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Int J Biochem Cell Biol 40:1536-42. 2008
    ..DNA containing a eukaryotic origin of replication has been studied in vitro by using native and recombinant HMGB1 as well as various modified HMGB1 preparations such as truncated protein, lacking its C-terminal tail, in vivo ..
  61. doi Native HMGB1 protein inhibits repair of cisplatin-damaged nucleosomes in vitro
    Iva Ugrinova
    Institute of Molecular Biology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Int J Biochem Cell Biol 41:1556-62. 2009
    ..Here, we report the first results that link HMGB1 to repair of cisplatin-treated DNA at nucleosome level...
  62. pmc Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation
    Roberta Palumbo
    Department of Molecular Biology and Functional Genomics, San Raffaele Research Institute, Milan, Italy
    J Cell Biol 164:441-9. 2004
    High mobility group box 1 (HMGB1) is an abundant chromatin protein that acts as a cytokine when released in the extracellular milieu by necrotic and inflammatory cells...
  63. ncbi Cisplatin ototoxicity to the rat inner ear: a role for HMG1 and iNOS
    Geming Li
    Department of Otolayngology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Neurotoxicology 27:22-30. 2006
    ..Binding of high-mobility group (HMG1) protein to cisplatin-modified DNA participates in mediating the antitumor effects of cisplatin...
  64. ncbi Alveolar macrophage suppression in sepsis is associated with high mobility group box 1 transmigration
    Madhuri Pahuja
    Department of Cell Biology, University of Medicine and Dentistry, NJ School of Osteopathic Medicine, Stratford, NJ 08084, USA
    Shock 29:754-60. 2008
    ....
  65. pmc HMGB binding to DNA: single and double box motifs
    Micah J McCauley
    Department of Physics, Northeastern University, Boston, MA 02115, USA
    J Mol Biol 374:993-1004. 2007
    ..as well as presence of a single box derivative of human HMGB2 [HMGB2(box A)] and a double box derivative of rat HMGB1 [HMGB1(box A+box B)]...
  66. ncbi Diurnal rhythm of the chromatin protein Hmgb1 in rat photoreceptors is under circadian regulation
    George Hoppe
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Comp Neurol 501:219-30. 2007
    b>Hmgb1 belongs to a family of structure-specific DNA binding proteins with DNA chaperone-like properties that mediate chromatin remodeling in a wide range of nuclear processes including regulation of transcription, DNA repair, genome ..
  67. ncbi Expression of HMGB1 during tooth development
    R Sugars
    Center for Oral Biology, Novum, Karolinska Institutet, Huddinge, Sweden
    Cell Tissue Res 327:511-9. 2007
    High mobility group box 1 (HMGB1) is a nuclear and cytosolic protein that can act as a transcription factor, a growth factor, or a cytokine...
  68. ncbi HMGB1 expression and release by bone cells
    Kanokwan Charoonpatrapong
    Department of Anatomy and Cell Biology, Indiana University School of Medicine IUSM, Indianapolis, Indiana 46202, USA
    J Cell Physiol 207:480-90. 2006
    ..A recent discovery reveals that DCs release the chromatin protein high mobility group box 1 (HMGB1) as a potent immunomodulatory cytokine mediating the interaction between DCs and T-cells, via HMGB1 binding to the ..
  69. pmc Determinants of HMGB proteins required to promote RAG1/2-recombination signal sequence complex assembly and catalysis during V(D)J recombination
    Yan Dai
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Cell Biol 25:4413-25. 2005
    ..that are competent for V(D)J cleavage requires the presence of the nonspecific DNA binding and bending protein HMGB1 or HMGB2...
  70. doi The role of high-mobility group box-1 in renal ischemia and reperfusion injury and the effect of ethyl pyruvate
    K Y Chung
    Department of Surgery, Ewha Womans University, School of Medicine, Ewha Medical Research Center, Seoul, Korea
    Transplant Proc 40:2136-8. 2008
    High mobility group box-1(HMGB1) was identified as a DNA-binding protein that functions as a cofactor for proper transcriptional regulation in somatic cells...
  71. pmc Borna disease virus phosphoprotein represses p53-mediated transcriptional activity by interference with HMGB1
    Guoqi Zhang
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    J Virol 77:12243-51. 2003
    ..it was demonstrated that a 24-kDa phosphoprotein (P) of BDV directly binds to a multifunctional protein, amphoterin-HMGB1, and inhibits its function in cultured neural cells (W. Kamitani, Y. Shoya, T. Kobayashi, M. Watanabe, B...
  72. doi Interactions of recombinant HMGB proteins with branched RNA substrates
    Anthony J Bell
    Department of Molecular Biology, Center for Computational and Integrative Biology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Biochem Biophys Res Commun 377:262-7. 2008
    The high mobility group protein HMGB1 is a highly abundant chromosomal protein known to interact preferentially with DNA that is branched, bent or otherwise structurally altered...
  73. doi Interplay between in vitro acetylation and phosphorylation of tailless HMGB1 protein
    Petar Pelovsky
    Institute of Molecular Biology, Bulgarian Academy of Sciences, Acad G Bonchev str bld 21, 1113 Sofia, Bulgaria
    Biochem Biophys Res Commun 380:138-42. 2009
    The postsynthetic acetylation of HMGB1 protein and its truncated form affects significantly its properties as "architectural" factor - recognition of bent DNA and bending of short DNA fragments...
  74. ncbi Nature of full-length HMGB1 binding to cisplatin-modified DNA
    Yongwon Jung
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Biochemistry 42:2664-71. 2003
    b>HMGB1, a highly conserved non-histone DNA-binding protein, interacts with specific DNA structural motifs such as those encountered at cisplatin damage, four-way junctions, and supercoils...
  75. doi Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain
    Il Doo Kim
    Department of Anatomy and Center for Advanced Medical Education BK21 project, Inha University School of Medicine, Inchon, Republic of Korea
    J Control Release 142:422-30. 2010
    ..The potential use of e-PAM-R was demonstrated by gene knockdown after transfecting High mobility group box-1 (HMGB1, a novel cytokine-like molecule) siRNA into H(2)O(2)- or NMDA-treated primary cortical cultures...
  76. ncbi GR and HMGB1 interact only within chromatin and influence each other's residence time
    Alessandra Agresti
    San Raffaele Research Institute, Via Olgettina 58, 20132 Milan, Italy
    Mol Cell 18:109-21. 2005
    ..We prove here that in living cells, the glucocorticoid receptor and HMGB1 interact only within chromatin and not in the nucleoplasm and decrease each other's mobility...
  77. ncbi [Effect of "Xuebijing injection" on expression of high mobility group box-1 protein and acute liver injury in rats with scald injury]
    Yan Bo Wang
    Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, China
    Zhonghua Shao Shang Za Zhi 25:171-5. 2009
    To investigate the effect of "Xuebijing injection" (Xuebijing in brief) on expression of hepatic high mobility group box-1 protein (HMGB1) and acute liver injury in rats with scald injury.
  78. pmc The DNA binding site of HMG1 protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins
    M E Bianchi
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Italy
    EMBO J 11:1055-63. 1992
    The mammalian nuclear protein HMG1 contains two segments that show a high sequence similarity to each other...
  79. ncbi The amphoterin (HMGB1)/receptor for advanced glycation end products (RAGE) pair modulates myoblast proliferation, apoptosis, adhesiveness, migration, and invasiveness. Functional inactivation of RAGE in L6 myoblasts results in tumor formation in vivo
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Casella Postale 81 Succursale 3, 06122 Perugia, Italy
    J Biol Chem 281:8242-53. 2006
    ..a multiligand receptor of the immunoglobulin superfamily expressed in myoblasts, when activated by its ligand amphoterin (HMGB1), stimulates rat L6 myoblast differentiation via a Cdc42-Rac-MKK6-p38 mitogen-activated protein kinase ..
  80. ncbi HMGB1 is a bone-active cytokine
    Jieping Yang
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Cell Physiol 214:730-9. 2008
    High mobility group box 1 (HMGB1) is a chromatin protein that acts as an immunomodulatory cytokine upon active release from myeloid cells...
  81. doi Effects of HMGB1 on PMN apoptosis during LPS-induced acute lung injury
    Yingkai Feng
    Institute of Pathology, Southwest Hospital affiliated to Third Military Medical University, Chongqing 400038, China
    Exp Mol Pathol 85:214-22. 2008
    To observe the effects of intravenous injection of HMGB1 inhibitor sodium butyrate on changes in apoptosis of PMN during LPS-induced acute lung injury in rats and HMGB1 in vitro on human circulating PMN apoptosis, in order to clarify the ..
  82. ncbi HMG-1 as regulatory trans-acting protein in the acute phase-induced expression of the rat liver haptoglobin gene
    I Grigorov
    Molecular Biology Laboratory, Institute for Biological Research, Belgrade, Federal Republic of Yugoslavia
    Gen Physiol Biophys 20:401-12. 2001
    ..In view of our previous and here shown data we assume that this increase could be a consequence of AP-induced release of HMG-1 from the chromatin and subsequent increase in its nuclear amount...
  83. ncbi Identity of nuclear high-mobility-group protein, HMG-1, and sulfoglucuronyl carbohydrate-binding protein, SBP-1, in brain
    D K Chou
    Department of Biomedical Sciences, Eunice Kennedy Shriver, Center for Mental Retardation, Waltham, Massachusetts 02452, USA
    J Neurochem 77:120-31. 2001
    ..The proteins also promoted neurite outgrowth in explant cultures of cerebellum. The results showed that the cerebellar HMG-1 and -2 proteins have similar biochemical and biological properties and HMG-1 is most likely identical to SBP-1...
  84. ncbi Nafamostat mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu, Oita 879 5593, Japan
    J Anesth 21:164-70. 2007
    High mobility group box 1 (HMGB1) protein has recently been shown to be an important late mediator of acute lung injury and a promising therapeutic target...
  85. ncbi Insulin attenuates the systemic inflammatory response in endotoxemic rats
    Marc G Jeschke
    Department of Surgery, Friedrich Alexander University of Erlangen, Erlangen, Germany
    Endocrinology 145:4084-93. 2004
    ..Insulin administration further decreased high mobility group 1 protein in the serum compared with controls...
  86. pmc DNA binding by single HMG box model proteins
    H Xin
    Department of Chemistry, New York University, 31 Washington Place, New York, NY 10003, USA
    Nucleic Acids Res 28:4044-50. 2000
    The HMG1/2 family is a large group of proteins that share a conserved sequence of approximately 80 amino acids rich in basic, aromatic and proline side chains, referred to as an HMG box...
  87. pmc Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE binding
    Guglielmo Sorci
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    Mol Cell Biol 24:4880-94. 2004
    ..expressed in skeletal muscle tissue and its expression is developmentally regulated and (ii) RAGE engagement by amphoterin (HMGB1), a RAGE ligand, in rat L6 myoblasts results in stimulation of myogenic differentiation via activation of ..
  88. doi Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis
    Asa Andersson
    Department of Clinical Neurosciences, Neuroimmunology Unit, Karolinska University Hospital at Solna, Karolinska Institutet, Stockholm, Sweden
    J Leukoc Biol 84:1248-55. 2008
    ..Herein, we demonstrate that high mobility group box chromosomal protein 1 (HMGB1), a DNA-binding protein with proinflammatory properties, is evident in active lesions of MS and experimental ..
  89. ncbi High mobility group box 1 induces a negative inotropic effect on the left ventricle in an isolated rat heart model of septic shock: a pilot study
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu 879 5593, Japan
    Circ J 72:1012-7. 2008
    ..High mobility group box 1 (HMGB1) protein is an important mediator in the pathogenesis of sepsis and its role in cardiovascular system dysfunction ..