Hmgb1

Summary

Gene Symbol: Hmgb1
Description: high mobility group box 1
Alias: Ac2-008, Hmg1, high mobility group protein B1, Ac2-008-like, HMG-1, amphoterin, heparin-binding protein p30, high mobility group 1, high mobility group protein 1
Species: rat

Top Publications

  1. doi Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Oita, Japan
    Crit Care Med 36:2407-13. 2008
  2. ncbi High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity
    Kazuyuki Takata
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    J Neurosci Res 78:880-91. 2004
  3. doi Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 34:402-6. 2010
  4. pmc Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1
    Sarah A Steer
    The Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri, USA
    PLoS Med 3:e17. 2006
  5. ncbi The significance of changes in high mobility group-1 protein mRNA expression in rats after thermal injury
    Wen Hui Fang
    The Department of Microbiology and Immunology, Trauma Research Center, Postgraduate Medical College, Beijing, People s Republic of China
    Shock 17:329-33. 2002
  6. doi Bile high-mobility group box 1 contributes to gut barrier dysfunction in experimental endotoxemia
    Runkuan Yang
    Dept of Critical Care Medicine, Univ of Pittsburgh Medical School, 1055 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Regul Integr Comp Physiol 297:R362-9. 2009
  7. doi The effect of experimental diabetes on high mobility group box 1 protein expression in endotoxin-induced acute lung injury
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 168:111-8. 2011
  8. ncbi [The effect of simvastatin on the expression of high mobility group box-1 protein in atherosclerotic rats]
    Ya xin Yin
    First Affiliated Hospital of General Hospital of PLA, Beijing 100048, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:306-8. 2010
  9. doi [Effect of qinghuobaiduyin on the expression of high mobility group box chromosomal protein 1 in macrophage]
    Ping Li
    Department of Burn and Plastics Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:766-70. 2010
  10. doi Expression analysis of high mobility group box-1 protein (HMGB-1) in the cerebral cortex, hippocampus, and cerebellum of the congenital hydrocephalus (H-Tx) rat
    Mitsuya Watanabe
    Department of Neurosurgery, Juntendo University, Bunkyoku, Tokyo, Japan
    Acta Neurochir Suppl 113:91-6. 2012

Scientific Experts

Detail Information

Publications122 found, 100 shown here

  1. doi Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Oita, Japan
    Crit Care Med 36:2407-13. 2008
    ..High mobility group box 1 (HMGB1) protein has been shown to play a key role as a significant factor in sepsis pathogenesis...
  2. ncbi High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity
    Kazuyuki Takata
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    J Neurosci Res 78:880-91. 2004
    ..High mobility group box protein-1 (HMGB1) is an abundant nonhistone chromosomal protein...
  3. doi Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 34:402-6. 2010
    ..Serum concentrations of cytokines (IL-1β, IL-6, and TNF-α), NO, and high-mobility group box 1 (HMGB1) protein were measured at various time points after treatment...
  4. pmc Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1
    Sarah A Steer
    The Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri, USA
    PLoS Med 3:e17. 2006
    ..IL-1, known to inhibit glucose-induced insulin secretion by stimulating inducible nitric oxide synthase expression and increased production of nitric oxide by beta-cells, also induces beta-cell death...
  5. ncbi The significance of changes in high mobility group-1 protein mRNA expression in rats after thermal injury
    Wen Hui Fang
    The Department of Microbiology and Immunology, Trauma Research Center, Postgraduate Medical College, Beijing, People s Republic of China
    Shock 17:329-33. 2002
    ..Up-regulation of HMG-1 expression may be involved in the pathogenesis of endogenous endotoxin-mediated multiple organ damage secondary to major burns...
  6. doi Bile high-mobility group box 1 contributes to gut barrier dysfunction in experimental endotoxemia
    Runkuan Yang
    Dept of Critical Care Medicine, Univ of Pittsburgh Medical School, 1055 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Regul Integr Comp Physiol 297:R362-9. 2009
    ..cells and extrahepatic macrophages release a large amount of the inflammatory cytokine high-mobility group box 1 (HMGB1) into the bile and that bile containing HMGB1 contributes to gut barrier dysfunction in experimental endotoxemia...
  7. doi The effect of experimental diabetes on high mobility group box 1 protein expression in endotoxin-induced acute lung injury
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 168:111-8. 2011
    ..For instance, diabetes is associated with altered immune and hemostatic responses. High mobility group box 1 (HMGB1) protein plays a key role in various inflammatory diseases...
  8. ncbi [The effect of simvastatin on the expression of high mobility group box-1 protein in atherosclerotic rats]
    Ya xin Yin
    First Affiliated Hospital of General Hospital of PLA, Beijing 100048, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:306-8. 2010
    To observe the effect of simvastatin on the expression of high mobility group box-1 protein (HMGB1) and morphology of atherosclerotic plaques in atherosclerotic rats, to ascertain whether HMGB1 plays a role in the preventive mechanism of ..
  9. doi [Effect of qinghuobaiduyin on the expression of high mobility group box chromosomal protein 1 in macrophage]
    Ping Li
    Department of Burn and Plastics Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:766-70. 2010
    To observe the expression of high mobility group box chromosomal protein 1(HMGB1) in RAW264...
  10. doi Expression analysis of high mobility group box-1 protein (HMGB-1) in the cerebral cortex, hippocampus, and cerebellum of the congenital hydrocephalus (H-Tx) rat
    Mitsuya Watanabe
    Department of Neurosurgery, Juntendo University, Bunkyoku, Tokyo, Japan
    Acta Neurochir Suppl 113:91-6. 2012
    ..We expect that, in the future, regulating the expression or functions of HMGB-1 will lead to the possibility of impeding the progress of neuronal damage caused by hydrocephalus...
  11. doi Surgery upregulates high mobility group box-1 and disrupts the blood-brain barrier causing cognitive dysfunction in aged rats
    Hui Juan He
    Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China
    CNS Neurosci Ther 18:994-1002. 2012
    ..Herein, we sought to determine the relationship between cognitive decline, blood-brain barrier (BBB) permeability, and inflammation, namely high mobility group box-1 (HMGB1), after surgery in aged rats.
  12. doi The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats
    Li Feng Huang
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, People s Republic of China
    Shock 31:322-9. 2009
    The aim of the present study was to investigate in vivo the effect of high-mobility group box 1 protein (HMGB1) on activity of regulatory T cells (Tregs) and the influence on T-cell-mediated immunity after thermal injury...
  13. doi Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling
    Takashi Kohno
    Cardiopulmonary Division, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cardiovasc Res 81:565-73. 2009
    High-mobility group box 1 protein (HMGB1) is one of the recently defined damage-associated molecular pattern molecules derived from necrotic cells and activated macrophages...
  14. pmc High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy
    Yoko Oyama
    Department of Laboratory and Vascular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Lab Invest 90:853-66. 2010
    ..The DNA-binding high-mobility group box-1 protein (HMGB1) initiates and propagates inflammation when released by activated macrophages, and functions as an 'alarm cytokine'..
  15. ncbi A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions
    M Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, CZ 612 65 Brno, Czech Republic
    J Biol Chem 275:35699-707. 2000
    ....
  16. pmc Borna disease virus phosphoprotein binds a neurite outgrowth factor, amphoterin/HMG-1
    W Kamitani
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    J Virol 75:8742-51. 2001
    ..analysis of the purified 30-kDa protein revealed that its N terminus showed complete homology with rat amphoterin protein, which is a neurite outgrowth factor abundant in the brain during development...
  17. ncbi alpha-Synuclein filaments bind the transcriptional regulator HMGB-1
    Evo K Lindersson
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
    Neuroreport 15:2735-9. 2004
    ..We identified the transcriptional co-factor high mobility group protein 1 (HMGB-1) as a ligand for alpha-synuclein filaments by a filament spin-down technique, mass ..
  18. pmc Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages
    Hiroki Kuniyasu
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    Am J Pathol 166:751-60. 2005
    High mobility group (HMGB)1/amphoterin is a multifunctional cytokine involved in invasion and metastasis of cancer and in inflammation...
  19. ncbi The high mobility group box chromosomal protein 1 is expressed in the human and rat testis where it may function as an antibacterial factor
    Cecilia K Zetterström
    Department of Woman and Child Health, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Hum Reprod 21:2801-9. 2006
    The high mobility group box chromosomal protein 1 (HMGB1) was originally shown to be a nuclear DNA-binding protein that activates transcription and promotes differentiation...
  20. ncbi Severity of sepsis is correlated with the elevation of serum high-mobility group box 1 in rats
    Li chao Hou
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Chin Med J (Engl) 122:449-54. 2009
    ..The late inflammatory cytokine, high-mobility group box 1 (HMGB1), plays a critical role in sepsis...
  21. ncbi 30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane
    J Merenmies
    Department of Medical Chemistry, University of Helsinki, Finland
    J Biol Chem 266:16722-9. 1991
    ..cDNA and peptide sequencing identified a dipolar sequence that has been previously found in studies of high mobility group 1 protein: the 184-amino acid cationic region is followed by a cluster of 30 anionic residues...
  22. pmc The adhesive and neurite-promoting molecule p30: analysis of the amino-terminal sequence and production of antipeptide antibodies that detect p30 at the surface of neuroblastoma cells and of brain neurons
    H Rauvala
    Department of Medical Chemistry, University of Helsinki, Finland
    J Cell Biol 107:2293-305. 1988
    ..A model summarizing the suggested interactions of p30 in cell adhesion and neurite growth is presented...
  23. ncbi The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system
    O Hori
    Department of Physiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 270:25752-61. 1995
    ..NH2-terminal and internal protein sequence data for p23 matched that reported previously for amphoterin. Amphoterin purified from rat brain or recombinant rat amphoterin bound to purified sRAGE in a saturable and ..
  24. ncbi Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases
    A Taguchi
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nature 405:354-60. 2000
    ..RAGE is a central cell surface receptor for amphoterin, a polypeptide linked to outgrowth of cultured cortical neurons derived from developing brain...
  25. ncbi HMG1 protein stimulates DNA end joining by promoting association of DNA molecules via their ends
    M Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Eur J Biochem 267:4088-97. 2000
    ..We demonstrate that HMG1 is able to enhance cohesive-end and blunt-end DNA ligation by T4 DNA ligase via its B domain...
  26. pmc High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
    U Andersson
    Department of Medicine, Rheumatology Unit, Karolinska Hospital, 17176 Stockholm, Sweden
    J Exp Med 192:565-70. 2000
    ..b>High mobility group 1 protein (HMG-1), a ubiquitous DNA-binding protein, was recently identified as a "late" mediator of ..
  27. pmc The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells
    B Degryse
    Department of Genetics and Microbiology, University of Milan, 20133 Milan, Italy
    J Cell Biol 152:1197-206. 2001
    HMG1 (high mobility group 1) is a ubiquitous and abundant chromatin component. However, HMG1 can be secreted by activated macrophages and monocytes, and can act as a mediator of inflammation and endotoxic lethality...
  28. ncbi Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    Paola Scaffidi
    DIBIT, Istituto Scientifico San Raffaele, 20132 Milano, Italy
    Nature 418:191-5. 2002
    b>High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets...
  29. ncbi High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis
    R Kokkola
    Rheumatology Research Unit, Karolinska Hospital, Stockholm 171 76, Sweden
    Arthritis Rheum 46:2598-603. 2002
    ..Macrophages play pivotal roles in the pathogenesis of arthritis. The aim of this study was to determine whether synovial macrophage expression of HMGB-1 is altered in human and experimental synovitis...
  30. pmc Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation
    Roberta Palumbo
    Department of Molecular Biology and Functional Genomics, San Raffaele Research Institute, Milan, Italy
    J Cell Biol 164:441-9. 2004
    High mobility group box 1 (HMGB1) is an abundant chromatin protein that acts as a cytokine when released in the extracellular milieu by necrotic and inflammatory cells...
  31. ncbi In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail
    Evdokia Pasheva
    Institute of Molecular Biology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Biochemistry 43:2935-40. 2004
    ..The alterations in the acetylation pattern of HMGB-1 and -2 upon removal of the C-terminal tail are regarded as a means by which the acidic domain modulates some properties of these proteins...
  32. ncbi Recombinant HMGB1 with cytokine-stimulating activity
    Jianhua Li
    Laboratories of Biomedical Science, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Immunol Methods 289:211-23. 2004
    We describe methods for the isolation, purification, and characterization of full-length high-mobility group box 1 (HMGB1) and truncated mutants expressed in bacteria and in mammalian Chinese Hamster Ovary (CHO) cells...
  33. ncbi RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages
    R Kokkola
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
    Scand J Immunol 61:1-9. 2005
    Abstract High-mobility group box chromosomal protein 1 (HMGB1) is a protein with both intranuclear functions and extracellular cytokine-like effects...
  34. ncbi Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats
    Keyue Liu
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    FASEB J 21:3904-16. 2007
    The high mobility group box-1 (HMGB1), originally identified as an architectural nuclear protein, exhibits an inflammatory cytokine-like activity in the extracellular space...
  35. ncbi HMGB1 is a bone-active cytokine
    Jieping Yang
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Cell Physiol 214:730-9. 2008
    High mobility group box 1 (HMGB1) is a chromatin protein that acts as an immunomodulatory cytokine upon active release from myeloid cells...
  36. ncbi Induction and subcellular localization of high-mobility group box-1 (HMGB1) in the postischemic rat brain
    Jung Bin Kim
    Department of Anatomy and Center for Advanced Medical Education BK21 project, Inha University School of Medicine, Inchon, Korea
    J Neurosci Res 86:1125-31. 2008
    High-mobility group box-1 (HMGB1) was originally identified as a ubiquitously expressed, abundant nonhistone DNA-binding protein...
  37. ncbi Mapping intramolecular interactions between domains in HMGB1 using a tail-truncation approach
    Matthew Watson
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    J Mol Biol 374:1286-97. 2007
    The mechanism underlying negative regulation of HMGB1-DNA interaction by the acidic C-terminal tail is ill defined...
  38. doi The role of high-mobility group box-1 in renal ischemia and reperfusion injury and the effect of ethyl pyruvate
    K Y Chung
    Department of Surgery, Ewha Womans University, School of Medicine, Ewha Medical Research Center, Seoul, Korea
    Transplant Proc 40:2136-8. 2008
    High mobility group box-1(HMGB1) was identified as a DNA-binding protein that functions as a cofactor for proper transcriptional regulation in somatic cells...
  39. doi Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart
    Kunihiko Takahashi
    Translational Cardiovascular Therapeutics, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK
    Circulation 118:S106-14. 2008
    ..High-mobility group box 1 (HMGB1) is a nuclear protein, which has recently been uncovered to also act as a modifier of inflammation when released...
  40. doi Effects of HMGB1 on PMN apoptosis during LPS-induced acute lung injury
    Yingkai Feng
    Institute of Pathology, Southwest Hospital affiliated to Third Military Medical University, Chongqing 400038, China
    Exp Mol Pathol 85:214-22. 2008
    To observe the effects of intravenous injection of HMGB1 inhibitor sodium butyrate on changes in apoptosis of PMN during LPS-induced acute lung injury in rats and HMGB1 in vitro on human circulating PMN apoptosis, in order to clarify the ..
  41. doi Intraocular expression and release of high-mobility group box 1 protein in retinal detachment
    Noboru Arimura
    Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Lab Invest 89:278-89. 2009
    High-mobility group box 1 (HMGB1) protein is a multifunctional protein, which is mainly present in the nucleus and is released extracellularly by dying cells and/or activated immune cells...
  42. doi The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation
    Hulda Sigridur Hreggvidsdottir
    Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Karolinska Institutet, S 171 76 Stockholm, Sweden
    J Leukoc Biol 86:655-62. 2009
    The nuclear protein HMGB1 has previously been demonstrated to act as an alarmin and to promote inflammation upon extracellular release, yet its mode of action is still not well defined...
  43. doi Neutralization of receptor for advanced glycation end-products and high mobility group box-1 attenuates septic diaphragm dysfunction in rats with peritonitis
    Yasuyuki Susa
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Crit Care Med 37:2619-24. 2009
    ..Extracellularly released high mobility group-box 1 can bind to cell surface receptors, such as receptor for advanced glycation end-products, eliciting inflammatory responses that lead to the development of sepsis...
  44. doi High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis
    Hideyuki Kawabata
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    Spine (Phila Pa 1976) 35:1109-15. 2010
    ..culture and rat spinal cord injury (SCI) model were used to examine the expression of high mobility group box 1 (HMGB1), TNF-alpha, and Rage by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemical ..
  45. doi Induction of high mobility group box-1 in dorsal root ganglion contributes to pain hypersensitivity after peripheral nerve injury
    Masayuki Shibasaki
    Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Pain 149:514-21. 2010
    ..Blocking HMGB-1/RAGE signalling might thus be a promising therapeutic strategy for the management of neuropathic pain...
  46. doi Spinal high-mobility group box 1 contributes to mechanical allodynia in a rat model of bone cancer pain
    Wei Tong
    Department of Out Patient, Xijing Hospital, Fourth Military Medical University, Xi an 710032, PR China
    Biochem Biophys Res Commun 395:572-6. 2010
    ..Being first reported as a nonhistone chromosomal protein, high-mobility group box 1 (HMGB1) is now implicated as a mediator of inflammation...
  47. pmc HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration
    Hui Ming Gao
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 31:1081-92. 2011
    ..Mechanistic studies indicated that HMGB1 (high-mobility group box 1), released from inflamed microglia and/or degenerating neurons, bound to microglial ..
  48. doi HMGB1 in ischemic and non-ischemic liver after selective warm ischemia/reperfusion in rat
    Anding Liu
    Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, Friedrich Schiller University Jena, Drackendorfer straße1, 07747, Jena, Germany
    Histochem Cell Biol 135:443-52. 2011
    High mobility group box 1 (HMGB1) acts as an early mediator in inflammation and organ injury. Ischemia reperfusion (I/R) injury induces HMGB1 translocation and expression in ischemic areas...
  49. doi HMGB1 translocation and expression is caused by warm ischemia reperfusion injury, but not by partial hepatectomy in rats
    Anding Liu
    Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, Friedrich Schiller University Jena, Jena 07747, Germany
    Exp Mol Pathol 91:502-8. 2011
    Mechanical injury or ischemia/reperfusion (I/R) injury induces high mobility of group box 1 (HMGB1) translocation and release...
  50. pmc Glucan phosphate attenuates myocardial HMGB1 translocation in severe sepsis through inhibiting NF-κB activation
    Tuanzhu Ha
    Department of Surgery, East Tennessee State University, Johnson City, Tennessee 37614 0575, USA
    Am J Physiol Heart Circ Physiol 301:H848-55. 2011
    ..High-mobility group box 1 (HMGB1) serves as a late mediator of lethality in sepsis...
  51. pmc Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 109:7505-10. 2012
    ..reactive astrocytes can release a damage-associated molecular-pattern molecule called high-mobility-group-box-1 (HMGB1) that promotes endothelial progenitor cell (EPC)-mediated neurovascular remodeling during stroke recovery...
  52. doi Anti-high mobility group box-1 antibody therapy for traumatic brain injury
    Yu Okuma
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Ann Neurol 72:373-84. 2012
    High mobility group box-1 (HMGB1) plays an important role in triggering inflammatory responses in many types of diseases...
  53. doi High-mobility group box1 protein promotes neuroinflammation after intracerebral hemorrhage in rats
    C Lei
    Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, PR China
    Neuroscience 228:190-9. 2013
    High-mobility group box1 (HMGB1) protein is massively released into the cytoplasm and induces inflammation following various insults such as sepsis, acute cerebral ischemia, and pancreatitis...
  54. doi High-mobility group box-1 protein activates inflammatory signaling pathway components and disrupts retinal vascular-barrier in the diabetic retina
    Ghulam Mohammad
    Department of Ophthalmology, College of Medicine, King Abdul Aziz University Hospital, King Saud University, P O Box 245, 11411 Riyadh, Saudi Arabia
    Exp Eye Res 107:101-9. 2013
    ..Our findings provide evidence that in the diabetic retina, HMGB-1 possibly interacts with RAGE and activates ERK(1/2) and NF-κB to generate an inflammatory response and disrupt retinal vascular barrier...
  55. doi Regulation of macrophage migration and activity by high-mobility group box 1 protein released from periodontal ligament cells during orthodontically induced periodontal repair: an in vitro and in vivo experimental study
    Michael Wolf
    Department of Orthodontics, University of Bonn, Rhenish Friedrich Wilhelm University, Welschnonnenstr 17, 53111, Bonn, Germany
    J Orofac Orthop 74:420-34. 2013
    ..Hypothesizing that high-mobility group box 1 (HMGB1) protein is released by mechanically stressed PDL cells into the extracellular space and has a role in mediating ..
  56. ncbi Structure of the A-domain of HMG1 and its interaction with DNA as studied by heteronuclear three- and four-dimensional NMR spectroscopy
    C H Hardman
    Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, UK
    Biochemistry 34:16596-607. 1995
    b>HMG1 has two homologous, folded DNA-binding domains ("HMG boxes"), A and B, linked by a short basic region to an acidic C-terminal domain...
  57. doi Relationship between high-mobility group box 1 protein release and T-cell suppression in rats after thermal injury
    Li Tian Zhang
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, People s Republic of China
    Shock 30:449-55. 2008
    To study whether high-mobility group box 1 protein (HMGB1) has an effect on T-cell-mediated immunity secondary to burn injury, 96 male Wistar rats weighing 250 to 300 g were randomly divided into three groups as follows:sham burn group, ..
  58. doi High-mobility group box 1 protein activates hepatic stellate cells in vitro
    Y H Kao
    Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Transplant Proc 40:2704-5. 2008
    Our previous study noticed remarkably elevated titers of anti-high-mobility group box 1 (HMGB1) antibodies in sera during the tolerance induction phase of a rat tolerogenic orthotopic liver transplantation (OLT) as well as in sera of ..
  59. ncbi Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation
    Maria Dolores Ledesma
    Cavalieri Ottolenghi Scientific Institute, Universita degli Studi di Torino, Ospedale San Luigi, Regione Gonzole 10, 10043 Turin, Orbassano, Italy
    Brain Res 987:107-16. 2003
    ..These observations suggest that neuronal rafts may play, in addition to intracellular signaling, a role in extracellular/membrane protein proteolysis...
  60. doi High mobility group box 1 (HMGB1) and macrophage migration inhibitory factor (MIF) in Kawasaki disease
    T Hoshina
    Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Scand J Rheumatol 37:445-9. 2008
    To investigate whether two proinflammatory cytokines, high mobility group box 1 (HMGB1) and macrophage migration inhibitory factor (MIF) are involved in the development of Kawasaki disease (KD).
  61. doi High-dose antithrombin III prevents heat stroke by attenuating systemic inflammation in rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University, Yufu City, Japan
    Inflamm Res 59:511-8. 2010
    Systemic inflammatory mediators, including the high mobility group box 1 (HMGB1) protein, play important roles in the development of various inflammatory conditions...
  62. pmc Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats
    Irshad Ali
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 93:282-8. 2012
    ..Furthermore, we examined activation of innate immune system components, high mobility group box 1 (HMGB1) and toll-like receptor 4 (TLR4), in this model as well as the effect of 20-5,14-HEDGE on this signaling pathway.
  63. doi Functional role of soluble receptor for advanced glycation end products in stroke
    Sung Chun Tang
    Stroke Center and Department of Neurology, National Taiwan University Hospital, Hospital, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 33:585-94. 2013
    ..Here, we aim to identify the role of plasma sRAGE and high mobility group box 1 (HMGB1) in imaging-confirmed IS patients, as well as mice subjected to focal ischemic stroke.
  64. pmc Sodium butyrate protects against severe burn-induced remote acute lung injury in rats
    Xun Liang
    Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, PR China
    PLoS ONE 8:e68786. 2013
    High-mobility group box 1 protein (HMGB1), a ubiquitous nuclear protein, drives proinflammatory responses when released extracellularly. It plays a key role as a distal mediator in the development of acute lung injury (ALI)...
  65. pmc Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1
    Yoki Nakamura
    Department of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
    PLoS ONE 8:e73640. 2013
    High mobility group box-1 (HMGB1) is associated with the pathogenesis of inflammatory diseases...
  66. doi Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition
    Xiao Li Chen
    Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People s Republic of China
    Br J Ophthalmol 97:1598-603. 2013
    ..to play a critical role in the pathogenesis of diabetic retinopathy, and high mobility group box protein 1 (HMGB1) could promote inflammation as an alarmin...
  67. pmc Extracellular high mobility group box 1 plays a role in the effect of bone marrow mononuclear cell transplantation for heart failure
    Masahiro Kaneko
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, United Kingdom
    PLoS ONE 8:e76908. 2013
    ..High mobility group box 1 (HMGB1) is a nuclear protein that stabilizes nucleosomes, and also acts as a multi-functional cytokine when released from ..
  68. pmc Two high-mobility group box domains act together to underwind and kink DNA
    R Sánchez-Giraldo
    Departament d Enginyeria Quimica, Universitat Politecnica de Catalunya, 08028 Barcelona, Spain
    Acta Crystallogr D Biol Crystallogr 71:1423-32. 2015
    High-mobility group protein 1 (HMGB1) is an essential and ubiquitous DNA architectural factor that influences a myriad of cellular processes...
  69. pmc Effects of bone marrow MSCs transfected with sRAGE on the intervention of HMGB1 induced immuno-inflammatory reaction
    Jun Wang
    Department of Hepatobiliary Surgery, Drum Tower Clinical Medical College of Nanjing Medical University Nanjing, China
    Int J Clin Exp Pathol 8:12028-40. 2015
    High mobility group box chromosomal protein 1 (HMGB1) is an important proinflammatory molecule in many inflammatory disorders, but little is known about its role in acute liver failure (ALF)...
  70. pmc High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury
    Athanasios Didangelos
    Wolfson Center for Age Related Diseases, Guys Campus, King s College London, United Kingdom
    Sci Rep 6:21607. 2016
    ..Extracellular high-mobility group box-1 (HMGB1) was identified as the likely endogenous regulator of IL1 expression after injury...
  71. doi Bone marrow stromal cells inhibits HMGB1-mediated inflammation after stroke in type 2 diabetic rats
    J Hu
    Department of Neurology, the Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu Province, China
    Neuroscience 324:11-9. 2016
    High-mobility group box 1 (HMGB1), a ligand of receptor for advanced glycation endproducts (RAGE), functions as a proinflammatory factor...
  72. doi Inhibiting High-Mobility Group Box 1 (HMGB1) Attenuates Inflammatory Cytokine Expression and Neurological Deficit in Ischemic Brain Injury Following Cardiac Arrest in Rats
    Mei Xu
    Department of Pediatrics, Tianjin Medical University General Hospital, Tianjin, 300052, China
    Inflammation 39:1594-602. 2016
    ..Previous studies have indicated that high-mobility group box 1 (HMGB1), a nuclear protein implicated in several inflammatory disorders, is involved in the inflammatory processes ..
  73. doi The role of high-mobility group box-1 protein in the development of diabetic nephropathy
    Junghyun Kim
    Diabetic Complications Research Center, Division of Traditional Korean Medicine Integrated Research, Korea Institute of Oriental Medicine, Daejeon, South Korea
    Am J Nephrol 33:524-9. 2011
    The purpose of the experiment reported here was to assess the involvement of high-mobility group box-1 (HMGB1), receptor for advanced glycation end products (RAGE) and nuclear factor (NF)-κB signaling pathway in the development of rat ..
  74. pmc HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B
    Ju Xian Song
    School of Chinese Medicine Hong Kong Baptist University Kowloon Tong Hong Kong
    Autophagy 10:144-54. 2014
    ..Furthermore, we showed that SNCA binds to both cytosolic and nuclear high mobility group box 1 (HMGB1), impairs the cytosolic translocation of HMGB1, blocks HMGB1-BECN1 binding, and strengthens BECN1-BCL2 binding...
  75. pmc Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and beta-2 integrin signaling
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital, Charlestown, MA, USA Harvard Medical School, USA Electronic address
    Stem Cell Res 12:531-8. 2014
    ..This process involved the release of soluble HMGB1 from reactive astrocytes that then upregulated endothelial expression of RAGE via Egr1 signaling...
  76. doi High-mobility group box 1 (HMGB1) impaired cardiac excitation-contraction coupling by enhancing the sarcoplasmic reticulum (SR) Ca(2+) leak through TLR4-ROS signaling in cardiomyocytes
    Cuicui Zhang
    Department of Pathophysiology, Key Laboratory for Shock and Microcirculation Research, Southern Medical University, Guangzhou, China
    J Mol Cell Cardiol 74:260-73. 2014
    High-mobility group box 1 (HMGB1) is a proinflammatory mediator playing an important role in the pathogenesis of cardiac dysfunction in many diseases...
  77. doi Activation of the high-mobility group box 1 protein-receptor for advanced glycation end-products signaling pathway in rats during neurogenesis after intracerebral hemorrhage
    Chunyan Lei
    From the Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People s Republic of China
    Stroke 46:500-6. 2015
    Following intracerebral hemorrhage (ICH), high-mobility group box 1 protein (HMGB1) may promote neurogenesis that supports functional recovery...
  78. doi Heatstroke induces liver injury via IL-1β and HMGB1-induced pyroptosis
    Yan Geng
    Department of Gastroenterology, 303 Hospital of People s Liberation Army, Nanning 530021, PR China Department of Intensive Care Unit, General Hospital of Guangzhou Military Command, Guangzhou 510010, PR China Electronic address
    J Hepatol 63:622-33. 2015
    ..Using a rat HS model, we identified a novel mechanism by which inflammasome-dependent interleukin-1β (IL-1β) activation and hepatocyte pyroptosis mediate HS-induced liver injury...
  79. doi Angiotensin II-induced hypertensive renal inflammation is mediated through HMGB1-TLR4 signaling in rat tubulo-epithelial cells
    Anand R Nair
    Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, United States
    Exp Cell Res 335:238-47. 2015
    ..The objective of this study was to elucidate the mechanistic role of HMGB1-TLR4 signaling in AngII-induced inflammation in the kidney.
  80. pmc Inhibition of high-mobility group box 1 expression by siRNA in rat hepatic stellate cells
    Wen Song Ge
    Department of Gastroenterology, Shanghai Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
    World J Gastroenterol 17:4090-8. 2011
    To explore the role of high-mobility group box 1 (HMGB1) protein during liver fibrogenesis and investigate the functional effects of HMGB1 gene silencing in hepatic stellate cells (HSCs) using siRNA.
  81. doi Heat shock transcription factor 1 inhibits H₂O₂-induced cardiomyocyte death through suppression of high-mobility group box 1
    Ying Yu
    Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai 200032, China
    Mol Cell Biochem 364:263-9. 2012
    ..In this study, we investigated the effects of HSF1-regulated HMGB1 on cardiomyocyte death...
  82. doi Evidence for the binding affinity of daunomycin to HMGB1 protein in chromatin and in solution
    Safa Lotfi
    Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Int J Biol Macromol 52:206-11. 2013
    In this study the interaction of daunomycin with HMGB1 nonhistone chromatin protein in the chromatin context using hydroxyapatite (HAP) column chromatography and free in solution was investigated employing fluorescence, circular ..
  83. doi High-mobility-group box protein 1A box reduces development of sodium laurate-induced thromboangiitis obliterans in rats
    Xiangqian Kong
    Department of Vascular Surgery, Provincial Hospital affiliated to Shandong University, Ji Nan, China
    J Vasc Surg 57:194-204. 2013
    High-mobility-group box protein 1 (HMGB1), as a late mediator of inflammation, plays a key role in inflammatory responses by inducing and extending the production of proinflammatory cytokines...
  84. doi High-mobility group box-1 and its receptors contribute to proinflammatory response in the acute phase of spinal cord injury in rats
    Ke Bing Chen
    Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Fukui, Japan
    Spine (Phila Pa 1976) 36:2122-9. 2011
    ..To examine the localization and expression of high-mobility group box-1 (HMGB-1) protein and its receptors after rat spinal cord injury...
  85. pmc Nucleotide sequence of rat liver HMG1 cDNA
    G Paonessa
    European Molecular Biology Laboratory, Heidelberg, FRG
    Nucleic Acids Res 15:9077. 1987
  86. pmc Structure of the HMG box motif in the B-domain of HMG1
    H M Weir
    Department of Biochemistry, University of Cambridge, UK
    EMBO J 12:1311-9. 1993
    The conserved, abundant chromosomal protein HMG1 consists of two highly homologous, folded, basic DNA-binding domains, each of approximately 80 amino acid residues, and an acidic C-terminal tail...
  87. ncbi Phosphorylation of HMG-I by protein kinase C attenuates its binding affinity to the promoter regions of protein kinase C gamma and neurogranin/RC3 genes
    D M Xiao
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Neurochem 74:392-9. 2000
    ..The current results suggest that phosphorylation of the mammalian HMG-I by PKC alone or in combination with cdc2 kinase provides an effective mechanism for the regulation of HMG-I function...
  88. ncbi Nature of full-length HMGB1 binding to cisplatin-modified DNA
    Yongwon Jung
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Biochemistry 42:2664-71. 2003
    b>HMGB1, a highly conserved non-histone DNA-binding protein, interacts with specific DNA structural motifs such as those encountered at cisplatin damage, four-way junctions, and supercoils...
  89. pmc Borna disease virus phosphoprotein represses p53-mediated transcriptional activity by interference with HMGB1
    Guoqi Zhang
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    J Virol 77:12243-51. 2003
    ..it was demonstrated that a 24-kDa phosphoprotein (P) of BDV directly binds to a multifunctional protein, amphoterin-HMGB1, and inhibits its function in cultured neural cells (W. Kamitani, Y. Shoya, T. Kobayashi, M. Watanabe, B...
  90. pmc Determinants of HMGB proteins required to promote RAG1/2-recombination signal sequence complex assembly and catalysis during V(D)J recombination
    Yan Dai
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Cell Biol 25:4413-25. 2005
    ..that are competent for V(D)J cleavage requires the presence of the nonspecific DNA binding and bending protein HMGB1 or HMGB2...
  91. ncbi Cisplatin ototoxicity to the rat inner ear: a role for HMG1 and iNOS
    Geming Li
    Department of Otolayngology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Neurotoxicology 27:22-30. 2006
    ..Binding of high-mobility group (HMG1) protein to cisplatin-modified DNA participates in mediating the antitumor effects of cisplatin...
  92. ncbi HMGB1 expression and release by bone cells
    Kanokwan Charoonpatrapong
    Department of Anatomy and Cell Biology, Indiana University School of Medicine IUSM, Indianapolis, Indiana 46202, USA
    J Cell Physiol 207:480-90. 2006
    ..A recent discovery reveals that DCs release the chromatin protein high mobility group box 1 (HMGB1) as a potent immunomodulatory cytokine mediating the interaction between DCs and T-cells, via HMGB1 binding to the ..
  93. ncbi Expression of HMGB1 during tooth development
    R Sugars
    Center for Oral Biology, Novum, Karolinska Institutet, Huddinge, Sweden
    Cell Tissue Res 327:511-9. 2007
    High mobility group box 1 (HMGB1) is a nuclear and cytosolic protein that can act as a transcription factor, a growth factor, or a cytokine...
  94. ncbi Diurnal rhythm of the chromatin protein Hmgb1 in rat photoreceptors is under circadian regulation
    George Hoppe
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Comp Neurol 501:219-30. 2007
    b>Hmgb1 belongs to a family of structure-specific DNA binding proteins with DNA chaperone-like properties that mediate chromatin remodeling in a wide range of nuclear processes including regulation of transcription, DNA repair, genome ..
  95. pmc HMGB binding to DNA: single and double box motifs
    Micah J McCauley
    Department of Physics, Northeastern University, Boston, MA 02115, USA
    J Mol Biol 374:993-1004. 2007
    ..as well as presence of a single box derivative of human HMGB2 [HMGB2(box A)] and a double box derivative of rat HMGB1 [HMGB1(box A+box B)]...
  96. ncbi Alveolar macrophage suppression in sepsis is associated with high mobility group box 1 transmigration
    Madhuri Pahuja
    Department of Cell Biology, University of Medicine and Dentistry, NJ School of Osteopathic Medicine, Stratford, NJ 08084, USA
    Shock 29:754-60. 2008
    ....
  97. doi HMGB1 protein inhibits DNA replication in vitro: a role of the acetylation and the acidic tail
    Dessislava Topalova
    Institute of Molecular Biology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Int J Biochem Cell Biol 40:1536-42. 2008
    ..DNA containing a eukaryotic origin of replication has been studied in vitro by using native and recombinant HMGB1 as well as various modified HMGB1 preparations such as truncated protein, lacking its C-terminal tail, in vivo ..
  98. doi Interactions of recombinant HMGB proteins with branched RNA substrates
    Anthony J Bell
    Department of Molecular Biology, Center for Computational and Integrative Biology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Biochem Biophys Res Commun 377:262-7. 2008
    The high mobility group protein HMGB1 is a highly abundant chromosomal protein known to interact preferentially with DNA that is branched, bent or otherwise structurally altered...
  99. doi Interplay between in vitro acetylation and phosphorylation of tailless HMGB1 protein
    Petar Pelovsky
    Institute of Molecular Biology, Bulgarian Academy of Sciences, Acad G Bonchev str bld 21, 1113 Sofia, Bulgaria
    Biochem Biophys Res Commun 380:138-42. 2009
    The postsynthetic acetylation of HMGB1 protein and its truncated form affects significantly its properties as "architectural" factor - recognition of bent DNA and bending of short DNA fragments...