Hif1an

Summary

Gene Symbol: Hif1an
Description: hypoxia-inducible factor 1, alpha subunit inhibitor
Alias: hypoxia-inducible factor 1-alpha inhibitor
Species: rat

Top Publications

  1. ncbi Gene expression profiles in hypoxic preconditioning using cDNA microarray analysis: altered expression of an angiogenic factor, carcinoembryonic antigen-related cell adhesion molecule 1
    Wen Jone Chen
    Department of Emergency Medicine, National Taiwan University Hospital and National Taiwan University Medical College, Taipei, 100, Taiwan
    Shock 24:124-31. 2005
  2. pmc FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells
    Yuichiro Hirose
    J Biol Chem 289:20594-605. 2014
  3. doi The role of the miR-31/FIH1 pathway in TGF-β-induced liver fibrosis
    Jiangfeng Hu
    Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China
    Clin Sci (Lond) 129:305-17. 2015
  4. ncbi Cardioprotective effect of miR-214 in myocardial ischemic postconditioning by down-regulation of hypoxia inducible factor 1, alpha subunit inhibitor
    D Y Wan
    Zhengzhou People and apos s Hospital Department of Cardiology Zhengzhou China
    Cell Mol Biol (Noisy-le-grand) 61:1-6. 2015
  5. doi Regulation of oxygen homeostasis by hypoxia-inducible factor 1
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, McKusick Nathans Institute of Genetic Medicine, Baltimore, Maryland, USA
    Physiology (Bethesda) 24:97-106. 2009
  6. pmc HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
    Brian Keith
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Cancer 12:9-22. 2011
  7. ncbi Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor
    Richard K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9152, USA
    Genes Dev 17:2614-23. 2003
  8. doi Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 78:857-67. 2010
  9. ncbi Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor
    Robert A Nordal
    Department of Radiation Oncology, Sunnybrook and Women s College Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 10:3342-53. 2004
  10. ncbi Hypoxia-inducible factor and nuclear factor kappa-B activation in blood-brain barrier endothelium under hypoxic/reoxygenation stress
    Ken A Witt
    Department of Pharmacology, University of Arizona, College of Medicine, Arizona 85724, USA
    J Neurochem 92:203-14. 2005

Research Grants

  1. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2002
  2. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2009

Scientific Experts

  • Gregg Semenza
  • Tzung Dau Wang
  • Richard K Bruick
  • Jiangfeng Hu
  • D Y Wan
  • Yuichiro Hirose
  • Brian Keith
  • Johannes Schödel
  • Isabel S S Hwang
  • Wen Jone Chen
  • Ken A Witt
  • Robert A Nordal
  • Qidong Liu
  • Jiuhong Kang
  • Chao Chen
  • Chaoqun Wu
  • Su Liu
  • Songchen Zhu
  • H H Yang
  • Baohai Liu
  • Chenlin Song
  • Z Zhang
  • Liang Zhu
  • Hongyu Yu
  • Dingkang Yao
  • Irving M Shapiro
  • Kazuhiro Chiba
  • Yoshiaki Toyama
  • Zariel I Johnson
  • Dessislava Z Markova
  • Zachary R Schoepflin
  • Makarand V Risbud
  • Randall S Johnson
  • M Celeste Simon
  • Armin Kurtz
  • Kai Uwe Eckardt
  • Kerstin Amann
  • Ursula Schlötzer-Schrehardt
  • Daniela Bohr
  • Christina Warnecke
  • Gunnar Schley
  • Carsten Willam
  • Bernd Klanke
  • Fai Tang
  • Emily C Liong
  • Man Lung Fung
  • George L Tipoe
  • Jeremy J W Chen
  • Thomas P Davis
  • Chien Hua Huang
  • Karen S Mark
  • Yuan Teh Lee
  • Chiang Ting Chien
  • Huei Wen Chen
  • Hsuan Yu Chen
  • Sung Liang Yu
  • Jason Huber
  • Pan Chyr Yang
  • Andras Nagy
  • Melania Pintilie
  • C Shun Wong

Detail Information

Publications11

  1. ncbi Gene expression profiles in hypoxic preconditioning using cDNA microarray analysis: altered expression of an angiogenic factor, carcinoembryonic antigen-related cell adhesion molecule 1
    Wen Jone Chen
    Department of Emergency Medicine, National Taiwan University Hospital and National Taiwan University Medical College, Taipei, 100, Taiwan
    Shock 24:124-31. 2005
    ..The HIF-1/vEGF/CEACAM-1 pathway might be important for hypoxia-induced angiogenesis in the heart during hypoxic preconditioning...
  2. pmc FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells
    Yuichiro Hirose
    J Biol Chem 289:20594-605. 2014
    ....
  3. doi The role of the miR-31/FIH1 pathway in TGF-β-induced liver fibrosis
    Jiangfeng Hu
    Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China
    Clin Sci (Lond) 129:305-17. 2015
    ..In conclusion, the miR-31/FIH1 pathway associates with liver fibrosis, perhaps by participation in the TGF-β/Smad3 signalling of HSCs. ..
  4. ncbi Cardioprotective effect of miR-214 in myocardial ischemic postconditioning by down-regulation of hypoxia inducible factor 1, alpha subunit inhibitor
    D Y Wan
    Zhengzhou People and apos s Hospital Department of Cardiology Zhengzhou China
    Cell Mol Biol (Noisy-le-grand) 61:1-6. 2015
    ..miR—214 and hypoxia inducible factor 1, alpha subunit inhibitor (HIF1AN) were analyzed by real—time quantitative polymerase chain reaction...
  5. doi Regulation of oxygen homeostasis by hypoxia-inducible factor 1
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, McKusick Nathans Institute of Genetic Medicine, Baltimore, Maryland, USA
    Physiology (Bethesda) 24:97-106. 2009
    ..HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively...
  6. pmc HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
    Brian Keith
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Cancer 12:9-22. 2011
    ..As HIF inhibitors are currently undergoing clinical evaluation as cancer therapeutics, a more thorough understanding of the unique roles performed by HIF1α and HIF2α in human neoplasia is warranted...
  7. ncbi Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor
    Richard K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9152, USA
    Genes Dev 17:2614-23. 2003
  8. doi Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 78:857-67. 2010
    ..Thus, FIH1 appears to be a suppressor of oxygen-dependent genes in the kidney, operating through HIF-dependent and -independent mechanisms...
  9. ncbi Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor
    Robert A Nordal
    Department of Radiation Oncology, Sunnybrook and Women s College Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 10:3342-53. 2004
    ..Because hypoxia mediates VEGF up-regulation through hypoxia-inducible factor-1alpha (HIF1alpha) induction, we studied the relationships of hypoxia, HIF1alpha expression, and expression of VEGF in this damage pathway...
  10. ncbi Hypoxia-inducible factor and nuclear factor kappa-B activation in blood-brain barrier endothelium under hypoxic/reoxygenation stress
    Ken A Witt
    Department of Pharmacology, University of Arizona, College of Medicine, Arizona 85724, USA
    J Neurochem 92:203-14. 2005
    ..These data offer novel avenues in which to alter and/or investigate BBB activity across model systems and to further our understanding of upstream regulators during hypoxia and H/R...
  11. ncbi Age-related changes in adrenomedullin expression and hypoxia-inducible factor-1 activity in the rat lung and their responses to hypoxia
    Isabel S S Hwang
    Department of Physiology, Faculty of Medicine, University of Hong Kong, Pokfulam, China
    J Gerontol A Biol Sci Med Sci 62:41-9. 2007
    ..Thus, the HIF-AM pathway may be impaired in the aged lung, and other mechanisms may be present to maintain an AM response to hypoxia...

Research Grants2

  1. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2002
    ..abstract_text> ..
  2. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2009
    ....