Hif1a

Summary

Gene Symbol: Hif1a
Description: hypoxia inducible factor 1 alpha subunit
Alias: MOP1, hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Species: rat

Top Publications

  1. pmc Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1
    Guofei Zhou
    Northwestern Univ, Chicago, IL 60611, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1120-30. 2009
  2. pmc Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follic
    Hena Alam
    Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Biol Chem 279:19431-40. 2004
  3. doi The role of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury
    Tetsuhiro Higashida
    Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosurg 114:92-101. 2011
  4. doi Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis
    Maya Shirakura
    Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Biochem Biophys Res Commun 393:800-5. 2010
  5. ncbi Hypoxia-inducible factor-1α is involved in the pro-angiogenic effect of hydrogen sulfide under hypoxic stress
    Xinhua Liu
    Department of Pharmacology, School of Pharmacy and Institute of Biomedical Sciences, Fudan University, Shanghai, China
    Biol Pharm Bull 33:1550-4. 2010
  6. ncbi Cardiac expressions of HIF-1 alpha and HLF/EPAS, two basic loop helix/PAS domain transcription factors involved in adaptative responses to hypoxic stresses
    A Ladoux
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, Valbonne, France
    Biochem Biophys Res Commun 240:552-6. 1997
  7. ncbi Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1
    R Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Diabetologia 45:1172-81. 2002
  8. ncbi Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1
    Juan C Chavez
    Department of Anatomy, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4938, USA
    J Neurosci 22:8922-31. 2002
  9. ncbi Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation
    Gisela D'Angelo
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 278:38183-7. 2003
  10. ncbi Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor
    Robert A Nordal
    Department of Radiation Oncology, Sunnybrook and Women s College Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 10:3342-53. 2004

Research Grants

Detail Information

Publications153 found, 100 shown here

  1. pmc Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1
    Guofei Zhou
    Northwestern Univ, Chicago, IL 60611, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1120-30. 2009
    ..Furthermore, both ROS and HIF-alpha were necessary for hypoxia-induced TGF-beta1 upregulation. Accordingly, we have provided evidence that hypoxia induces EMT of AEC through mitochondrial ROS, HIF, and endogenous TGF-beta1 signaling...
  2. pmc Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follic
    Hena Alam
    Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Biol Chem 279:19431-40. 2004
    ..These results show that FSH enhances HIF-1 activity downstream of the PI 3-kinase/AKT/Rheb/mTOR pathway in GCs and that HIF-1 activity is necessary for FSH to induce multiple follicular differentiation markers...
  3. doi The role of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury
    Tetsuhiro Higashida
    Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosurg 114:92-101. 2011
    ....
  4. doi Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis
    Maya Shirakura
    Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Biochem Biophys Res Commun 393:800-5. 2010
    ..Inductions of Hif-1-target genes showed a similar expression pattern. In addition, expression of Opg decreased in hypoxia, and Hif-1alpha played a role, in part, in its regulation...
  5. ncbi Hypoxia-inducible factor-1α is involved in the pro-angiogenic effect of hydrogen sulfide under hypoxic stress
    Xinhua Liu
    Department of Pharmacology, School of Pharmacy and Institute of Biomedical Sciences, Fudan University, Shanghai, China
    Biol Pharm Bull 33:1550-4. 2010
    ..H2S also significantly upregulated HIF-1alpha and VEGF protein levels and increased HIF-1alpha binding activity under hypoxic condition. Our findings suggest that HIF-1/VEGF is involved in H2S promotes proliferation and migration of ECs...
  6. ncbi Cardiac expressions of HIF-1 alpha and HLF/EPAS, two basic loop helix/PAS domain transcription factors involved in adaptative responses to hypoxic stresses
    A Ladoux
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, Valbonne, France
    Biochem Biophys Res Commun 240:552-6. 1997
    ..Finally, they suggest that protein kinase C may prime hypoxia induced gene regulation by inducing expression of HIF-1 alpha mRNAs...
  7. ncbi Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1
    R Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Diabetologia 45:1172-81. 2002
    ..This study aimed to evaluate the effects of hyperglycaemia on the evolution of myocardial infarction and the expression of the transcriptional factor for angiogenesis hypoxia-inducible factor 1alpha (HIF-1alpha) in the rat...
  8. ncbi Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1
    Juan C Chavez
    Department of Anatomy, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4938, USA
    J Neurosci 22:8922-31. 2002
    ..Our study suggest that activation of HIF-1 might be part of the mechanism by which IGF-1 promotes cell survival after cerebral ischemia...
  9. ncbi Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation
    Gisela D'Angelo
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 278:38183-7. 2003
    ..The results suggest that a hypoxic upregulation of PHD (presumably PHD-2) acts as a feedback mechanism to stop hypoxic responses in reoxygenated cells. We propose that proline hydroxylation might play a role in hypoxic preconditioning...
  10. ncbi Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor
    Robert A Nordal
    Department of Radiation Oncology, Sunnybrook and Women s College Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 10:3342-53. 2004
    ..Because hypoxia mediates VEGF up-regulation through hypoxia-inducible factor-1alpha (HIF1alpha) induction, we studied the relationships of hypoxia, HIF1alpha expression, and expression of VEGF in this damage pathway...
  11. ncbi Gene expression profiles in hypoxic preconditioning using cDNA microarray analysis: altered expression of an angiogenic factor, carcinoembryonic antigen-related cell adhesion molecule 1
    Wen Jone Chen
    Department of Emergency Medicine, National Taiwan University Hospital and National Taiwan University Medical College, Taipei, 100, Taiwan
    Shock 24:124-31. 2005
    ..The HIF-1/vEGF/CEACAM-1 pathway might be important for hypoxia-induced angiogenesis in the heart during hypoxic preconditioning...
  12. ncbi Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment
    Makarand V Risbud
    Department of Orthopaedic Surgery and Graduate Program in Tissue Engineering and Regenerative Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107
    J Cell Biochem 98:152-9. 2006
    ..The study confirmed that HIF-1alpha can be used as a phenotypic marker of nucleus pulposus cells...
  13. ncbi Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia
    Manuela Zampino
    Section of Cardiology, Center for Cardiovascular Research, Univ of Illinois at Chicago, 840 South Wood St, M C 787, Chicago, IL 60612, USA
    Am J Physiol Heart Circ Physiol 291:H957-64. 2006
    ....
  14. ncbi Evidence of HIF-1 functional binding activity to caspase-3 promoter after photothrombotic cerebral ischemia
    Michael van Hoecke
    Laboratoire de Pharmacodynamie et Physiologie Pharmaceutique, Faculte de Pharmacie, 7 Boulevard Jeanne d Arc, BP 87900, 21079 Dijon Cedex, France
    Mol Cell Neurosci 34:40-7. 2007
    ..Altogether the present data provide strong arguments for a causative relationship between HIF-1alpha and caspase-3 inductions through a functional binding activity to the caspase-3 gene promoter...
  15. ncbi Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia
    Ryon M Bateman
    University of British Columbia Critical Care Research Laboratories, Department of Medicine, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Physiol Heart Circ Physiol 293:H448-56. 2007
    ..HIF-1alpha and GLUT1 gene induction are related to a heterogeneous ICAM-1 expression and may be cardioprotective during the onset of septic injury...
  16. ncbi HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral disc
    Yan Zeng
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    J Bone Miner Res 22:1851-61. 2007
    ..Our studies indicate that HIF-1 alpha regulates galectin-3 expression by interacting with hypoxia regulatory elements in the promoter region. Finally, we show that galectin-3 serves a prosurvival role in the intervertebral disc...
  17. ncbi Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression
    Miriam Echevarria
    Laboratorio de Investigaciones Biomedicas, Departamento de Fisiologia Medica y Biofisica, Hospital Universitario Virgen del Rocio, Universidad de Sevilla, Sevilla, 41013 Spain
    J Biol Chem 282:30207-15. 2007
    ..Moreover, lung AQP-1 is markedly up-regulated in animals exposed to hypoxia. These data suggest that AQP-1 has O(2) permeability and thus could facilitate O(2) diffusion across the cell membrane...
  18. ncbi Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor alpha/retinoid X receptor
    Adam J Belanger
    Genzyme Corporation, 49 New York Avenue, Framingham, MA 01701, USA
    Biochem Biophys Res Commun 364:567-72. 2007
    ..These results suggest that HIF-1 may be involved in hypoxia-induced suppression of fatty acid metabolism in cardiomyocytes by reducing the DNA binding activity of PPARalpha/RXR...
  19. pmc Active HIF-1 in the normal human retina
    John M Hughes
    Department of Ophthalmology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Histochem Cytochem 58:247-54. 2010
    ..In human retina, staining of VEGF, GLUT-1, and CAIX was found. Our observations indicate that active HIF-1 signaling occurs constitutively in the normal human and rat retina, suggesting that HIF-1 has a physiological role in the retina...
  20. ncbi Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression
    John D Powell
    Biology Department, Monmouth University, West Long Branch, New Jersey 07764, USA
    Biol Reprod 67:995-1002. 2002
    ..HIF-1alpha protein was also elevated by experimental torsion and reperfusion compared with normoxic controls. These results support the hypothesis that HIF-1 may play a role in the cellular response to hypoxia in the ischemic testis...
  21. ncbi Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms
    Elisabeth L Pagé
    Centre de recherche de L Hôtel Dieu de Québec, Canada
    J Biol Chem 277:48403-9. 2002
    ..Elucidation of these signaling pathways that up-regulate the vascular endothelial growth factor (VEGF) could have a strong impact on different aspects of vascular biology...
  22. ncbi Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1
    Agnes Gorlach
    Experimentelle Kinderkardiologie, Deutsches Herzzentrum Müchen and der Technischen Universität Müchen, Munich, Germany
    Thromb Haemost 89:926-35. 2003
    ..In contrast, NFkappaB activation was enhanced in RacG12V-cells, but abolished by RacT17N. Thus, these findings suggest a mechanism explaining modified fibrinolysis and tissue remodeling in an oxidized environment...
  23. pmc Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis
    Alexandra Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Arthritis Res Ther 5:R193-201. 2003
    ..The activation of the HIF-alpha pathway occurs in both RA and OA, although for unrelated reasons...
  24. ncbi The transcription factors hypoxia-inducible factor 1alpha and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritis
    C L Peters
    University of Bath, Bath, UK
    Arthritis Rheum 50:291-6. 2004
    ..Adjuvant-induced arthritis (AIA) was used as the model system, since it mirrors many aspects of the pathology of rheumatoid arthritis...
  25. ncbi Regulatory role of vHL/HIF-1alpha in hypoxia-induced VEGF production in hepatic stellate cells
    Yang Q Wang
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
    Biochem Biophys Res Commun 317:358-62. 2004
    ..Inhibition of COX-2 activities would prevent vHL protein from degradation and suppress HIF-1alpha up-regulation. Thus, vHL/HIF-1alpha has a regulatory role in COX-2-mediated VEGF production in hypoxic stellate cells in injured liver...
  26. ncbi HIF-1alpha reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion
    C Matrone
    Division of Pharmacology, Department of Neuroscience, School of Medicine, Federico II University, Naples, Italy
    J Neurochem 90:368-78. 2004
    ..Our study suggests that the activation of HIF-1 might be involved in the mechanisms whereby iNOS promotes cell survival and/or death after cerebral ischemia...
  27. ncbi Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia
    Guoxiang Yuan
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 280:4321-8. 2005
    ..These observations suggest that IH induces HIF-1 transcriptional activity via a novel signaling pathway involving CaM kinase...
  28. ncbi Up-regulation of HIF in experimental acute renal failure: evidence for a protective transcriptional response to hypoxia
    Christian Rosenberger
    Department of Nephrology and Medical Intensive Care, Charite University Medicine, Berlin, Germany
    Kidney Int 67:531-42. 2005
    ..Hypoxia-inducible transcription factors (HIF) are recognized as master regulators of hypoxic adaptation, but little is known about their role in renal disease...
  29. ncbi Chromatin immunoprecipitation analysis of gene expression in the rat uterus in vivo: estrogen-induced recruitment of both estrogen receptor alpha and hypoxia-inducible factor 1 to the vascular endothelial growth factor promoter
    Armina A Kazi
    Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201, USA
    Mol Endocrinol 19:2006-19. 2005
    ..In contrast to the uterus, HEC1A cells cultured in 95% air-5% CO2 (and therefore 20% O2) contained no HIF-1alpha, consistent with the inability of E2 to stimulate the expression of VEGF by these and other cell types in vitro...
  30. ncbi Angiotensin II regulates vascular endothelial growth factor via hypoxia-inducible factor-1alpha induction and redox mechanisms in the kidney
    Elsa Sanchez-Lopez
    Laboratory of Vascular and Renal Pathology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Antioxid Redox Signal 7:1275-84. 2005
    ..In summary, these data show that AngII in vivo and in vitro up-regulates renal VEGF expression by a mechanism that involves HIF-1 activation and oxidative stress...
  31. ncbi Calcium signaling stimulates translation of HIF-alpha during hypoxia
    Anna S Hui
    Department of Genome Science, Genome Research Institute, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0505, USA
    FASEB J 20:466-75. 2006
    ....
  32. ncbi Chronic in vivo hypoxia in various organs: hypoxia-inducible factor-1alpha and apoptosis
    Paola Bianciardi
    Department of Medicine, Surgery, and Dentistry, University of Milan, San Paolo Hospital, Milan, Italy
    Biochem Biophys Res Commun 342:875-80. 2006
    ..We conclude that the HIF-1alpha response to chronic hypoxia can be a sustained phenomenon, but not in all organs, and that apoptosis responds differently from HIF-1alpha...
  33. ncbi Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure
    Wanja M Bernhardt
    Department of Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University Erlangen Nuremberg, Loschgestrasse, Erlangen, Germany
    J Am Soc Nephrol 17:1970-8. 2006
    ..In conclusion, the data provide proof of principle that preconditional activation of the HIF system protects against ischemic injury. Inhibiting the activity of HIF hydroxylases therefore seems to have considerable clinical perspectives...
  34. ncbi Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway
    Armina A Kazi
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201 1559, USA
    Endocrinology 148:2363-74. 2007
    ..These findings not only shed light on estrogen action in normal target tissues but also have important implications for cancer biology because excessive PI3K, HIF-1alpha, and VEGF activity are common in estrogen-dependent tumors...
  35. ncbi Differential regulation of hypoxia-inducible factor-1 through receptor tyrosine kinase transactivation in vascular smooth muscle cells
    Marie Claude Lauzier
    Centre de recherche de L Hôtel Dieu de Québec, 10 Rue McMahon, Quebec, Canada G1R 2J6
    Endocrinology 148:4023-31. 2007
    ..These findings identify novel and intricate signaling mechanisms involved in HIF-1 complex activation...
  36. ncbi Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia
    Oxana Baranova
    Burke Medical Research Institute, White Plains, New York 10605, USA
    J Neurosci 27:6320-32. 2007
    ....
  37. ncbi Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model
    Shuichi Ohtomo
    Institute of Medical Sciences and Division of Nephrology, Hypertension and Metabolism, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Nephrol Dial Transplant 23:1166-72. 2008
    ..Cobalt enhances the activity of the hypoxia-inducible factor (HIF), a key factor in the defence against hypoxia. Its long-term effect on DN is evaluated...
  38. doi Glucose up-regulates HIF-1 alpha expression in primary cortical neurons in response to hypoxia through maintaining cellular redox status
    Shuhong Guo
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Neurochem 105:1849-60. 2008
    ..The results imply that hypoxia only may not be sufficient to stabilize HIF-1alpha and that a reducing environment is required to stabilize HIF-1alpha in neurons exposed to hypoxia...
  39. pmc Salt-sensitive hypertension induced by decoy of transcription factor hypoxia-inducible factor-1alpha in the renal medulla
    Ningjun Li
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298, USA
    Circ Res 102:1101-8. 2008
    ..In conclusion, HIF-1alpha-mediated gene activation importantly participates in the regulation of renal medullary function and long-term arterial blood pressure...
  40. pmc Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR
    Guoxiang Yuan
    The Center for Systems Biology, Department of Medicine, University of Chicago, Illinois 60637, USA
    J Cell Physiol 217:674-85. 2008
    ..Rapamycin or cycloheximide, blocked increased HIF-1alpha levels during re-oxygenation indicating that mTOR-dependent protein synthesis is required for the persistent elevation of HIF-1alpha levels during re-oxygenation...
  41. pmc PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
    Kathleen A O'Hagan
    Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 106:2188-93. 2009
    ....
  42. doi Hypoxia-inducible factor 1/heme oxygenase 1 cascade as upstream signals in the prolife role of heat shock protein 70 at rostral ventrolateral medulla during experimental brain stem death
    Alice Y W Chang
    Center for Translational Research in Biomedical Sciences, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung County, Republic of China
    Shock 32:651-8. 2009
    ....
  43. doi Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea
    Elise Belaidi
    INSERM, Grenoble, France
    J Am Coll Cardiol 53:1309-17. 2009
    ..Our aim was to investigate the involvement of the endothelin (ET) system in the cardiovascular consequences of intermittent hypoxia (IH)...
  44. doi Sphingosine-1-phosphate: a novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells
    Maude D Michaud
    Centre de recherche du CHUQ, L Hôtel Dieu de Québec, Quebec, Canada
    Arterioscler Thromb Vasc Biol 29:902-8. 2009
    ..Studies have shown that nonhypoxic stimuli can activate HIF-1 in oxygenated conditions. Here, we attempt to determine whether S1P can modulate the vascular activation of HIF-1...
  45. doi Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney
    Young Rim Song
    Department of Internal Medicine and Kidney Research Institute, Hallym University College of Medicine, Anyang, Korea
    Nephrol Dial Transplant 25:77-85. 2010
    ..In this study, we investigated whether HIF activation could attenuate renal injury in the rat remnant kidney model...
  46. doi Repetitive hypoxic preconditioning attenuates renal ischemia/reperfusion induced oxidative injury via upregulating HIF-1 alpha-dependent bcl-2 signaling
    Chih Ching Yang
    Department of Health, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Transplantation 88:1251-60. 2009
    ..We hypothesized that repetitive hypoxic preconditioning (RHP) may provide long-lasting protection than single preconditioning against ischemia/reperfusion injury in rat kidneys through hypoxia-induced factor (HIF)-1-dependent pathway...
  47. pmc Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha
    Mylène Heinis
    INSERM U845, Research Center Growth and Signalling, Universite Paris Descartes, Hopital Necker, Paris, France
    Diabetes 59:662-9. 2010
    ..Variations of pO2 are mediated through the hypoxia-inducible factor (HIF), a crucial mediator of the adaptative response of cells to hypoxia. The aim of this study was to investigate the role of pO2 in beta-cell differentiation...
  48. pmc The effect of hypoxia-inducible factor 1-alpha on hypoxia-induced apoptosis in primary neonatal rat ventricular myocytes
    Yan Fang Zhou
    Department of Cardiology, First Affiliated Hospital of China Medical University, Shenyang, China
    Cardiovasc J Afr 21:37-41. 2010
    ..To study the role of hypoxia-inducible factor 1-alpha (HIF-1alpha) on hypoxia-induced apoptosis in primary neonatal rat ventricular myocytes...
  49. doi Microtubular stability affects cardiomyocyte glycolysis by HIF-1alpha expression and endonuclear aggregation during early stages of hypoxia
    Miao Teng
    Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Third Military Medical Univ, Chongqing 400038, China
    Am J Physiol Heart Circ Physiol 298:H1919-31. 2010
    ..These findings provide potential therapeutic targets for ameliorating cell energy metabolism during early myocardial hypoxia...
  50. pmc Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla
    Zhengchao Wang
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298, USA
    Hypertension 55:1129-36. 2010
    ..The lack of PHD-mediated response to high salt may represent a pathogenic mechanism producing salt-sensitive hypertension...
  51. pmc Hypoxia-inducible factor-1α contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells
    Zhengchao Wang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Kidney Int 79:300-10. 2011
    ..We propose that redox regulation of prolyl-PHD2 plays a critical role in angiotensin II-induced activation of HIF-1α in renal cells...
  52. pmc Silencing of hypoxia-inducible factor-1α gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats
    Qing Zhu
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Hypertension 58:657-64. 2011
    ....
  53. pmc Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats
    Qing Zhu
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richnond VA 23298, USA
    Biochim Biophys Acta 1822:936-41. 2012
    ....
  54. pmc Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival
    Elisa Conde
    Department of System Disorders and Cancer, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Alcala University, Madrid, Spain
    PLoS ONE 7:e33258. 2012
    ..In summary, using experimental models and human biopsies, we identified a novel HIF-1 α induction during reperfusion with a potential critical role in renal transplant...
  55. pmc Microtubular stability affects pVHL-mediated regulation of HIF-1alpha via the p38/MAPK pathway in hypoxic cardiomyocytes
    Miao Teng
    Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University, Chongqing, China
    PLoS ONE 7:e35017. 2012
    ..The von Hippel-Lindau tumor suppressor protein (pVHL), as a ubiquitin ligase, is best understood as a negative regulator of HIF-1α...
  56. pmc Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis
    Guoxiang Yuan
    Biological Sciences Division, Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 110:E1788-96. 2013
    ....
  57. ncbi Heart HIF-1alpha and MAP kinases during hypoxia: are they associated in vivo?
    Anna Caretti
    Department of Medicine, University of Milan, San Paolo Hospital, Milan, Italy
    Exp Biol Med (Maywood) 232:887-94. 2007
    ..In conclusion, although very sensitive to the reoxygenation, HIF-1alpha is overexpressed in vivo in the hypoxic myocardium, and its acute induction by hypoxia is correlated with that of p38...
  58. ncbi Identification of potential stroke targets by lentiviral vector mediated overexpression of HIF-1 alpha and HIF-2 alpha in a primary neuronal model of hypoxia
    G S Ralph
    Oxford BioMedica Ltd, UK
    J Cereb Blood Flow Metab 24:245-58. 2004
    ..Further investigation of the genes identified in this study may provide increased understanding of the neuronal response to hypoxia and may uncover novel therapeutic targets for the treatment of cerebral ischemia...
  59. ncbi Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair
    D E Komatsu
    Department of Biomedical Engineering, Stony Brook University, NY 11794 2580, USA
    Bone 34:680-8. 2004
    ....
  60. ncbi [Effect of opening of mitochondrial ATP-sensitive K(+) channels on the expression of hypoxia inducible factor-1alpha and cell proliferation in pulmonary arterial smooth muscle cells of rats]
    Jian Ping Zhao
    Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Sheng Li Xue Bao 59:157-62. 2007
    ..This might be a mechanism of the development of hypoxic pulmonary hypertension...
  61. doi Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1 alpha and CREB
    Jianhua Feng
    Cardiovascular Anesthesia Research Laboratory, Center of Clinical Research, Institute of Anesthesiology, E HOF, University Hospital Zurich, Ramistrasse 100, Zurich CH 8091, Switzerland
    Cardiovasc Res 78:98-107. 2008
    ..We tested whether delayed pharmacologic preconditioning elicited by isoflurane is protective in infarct-remodelled hearts...
  62. doi Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes
    Bryan P Schneider
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Breast Cancer Res Treat 116:543-9. 2009
    ..We evaluated the association between germline polymorphisms in genes important to angiogenesis and subjective reporting of hot flashes...
  63. pmc Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: possible implications in controlling dystrophic mineralization in the intervertebral disc
    Renata Skubutyte
    Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Arthritis Rheum 62:2707-15. 2010
    ..Since nucleus pulposus cells reside under conditions of hypoxia, we determined if the expression of ANK, a pyrophosphate transporter, is regulated by the hypoxia-inducible factor (HIF) proteins...
  64. doi Dihydrotestosterone attenuates hypoxia inducible factor-1α and cyclooxygenase-2 in cerebral arteries during hypoxia or hypoxia with glucose deprivation
    Kristen L Zuloaga
    Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona, USA
    Am J Physiol Heart Circ Physiol 301:H1882-90. 2011
    ..These results demonstrate that upregulation of COX-2 and HIF-1α in response to hypoxia is suppressed by DHT via an androgen receptor-independent mechanism...
  65. doi Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss
    Alice Ly
    Department of Anatomy and Cell Biology, University of Melbourne, Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 52:9316-26. 2011
    ....
  66. doi Intraabdominal adhesion formation is associated with differential mRNA expression of metabolic genes PDHb and SDHa
    Markus Wallwiener
    Department of Obstetrics and Gynaecology, Heidelberg University Hospital, Vossstr 9, 69115, Heidelberg, Germany
    Arch Gynecol Obstet 286:683-6. 2012
    ..We therefore investigated the gene expression of HIF-1 and two pivotal metabolic genes, pyruvate-dehydrogenaseβ (PDHb) and succinate-dehydrogenase-complex-subunit-A (SDHa) in a validated ischemia model of adhesion formation...
  67. ncbi Hepatic response to chronic hypoxia in experimental rat model through HIF-1 alpha, activator protein-1 and NF-kappa B
    Thomas Y H Lau
    Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong SAR
    Histol Histopathol 28:463-71. 2013
    ..The increased expression of VEGF, ET-1, iNOS and eNOS may be partly due to the compensatory mechanism in the vascular beds of the liver in response to chronic hypoxia...
  68. pmc Hypoxia antagonizes glucose deprivation on interleukin 6 expression in an Akt dependent, but HIF-1/2α independent manner
    Sung Ji Choi
    Laboratory of Genome to Drug Medicine, Joint Center for Biosciences, Incheon, Korea
    PLoS ONE 8:e58662. 2013
    ..However, inhibition of HIF-1/2α did not reverse the effects of hypoxia on IL-6 gene expression. In addition, phosphorylation of p38, but not JNK, was responsible for the effects of glucose deprivation on IL-6 gene expression...
  69. pmc Hypoxic preconditioning with cobalt of bone marrow mesenchymal stem cells improves cell migration and enhances therapy for treatment of ischemic acute kidney injury
    Xiaofang Yu
    Department of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    PLoS ONE 8:e62703. 2013
    ..Thus we suggest that by enhancing MSC migration and prolonging kidney retention, hypoxic preconditioning of MSC may be a useful approach for developing AKI cell therapy...
  70. ncbi Effect of pioglitazone on expression of hypoxia-inducible factor 1α and vascular endothelial growth factor in ischemic hindlimb of diabetic rats
    M Zhang
    Department of Endocrinology, Qingpu Branch, Zhongshan Hospital, Fudan University, China
    Eur Rev Med Pharmacol Sci 18:1307-14. 2014
    ....
  71. ncbi [Effect of leptin on lung fibrosis of silicosis rats and the correlation between leptin and HIF-1α expressions]
    Houshuang Pei
    Department of Respiratory Medicine, Central Hospital of Datun Coal Company, Xuzhou 221611, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30:700-3. 2014
    ..To observe the expression of leptin (LP) and its influence on pulmonary fibrosis in experimental rats with silicosis and the correlation between the expressions of leptin and HIF-1α...
  72. doi Chronic intermittent hypoxia decreases pain sensitivity and increases the expression of HIF1α and opioid receptors in experimental rats
    Jian Wu
    Department of Anesthesiology, Shengjing Hospital, China Medical University, No 36 Sanhao Street, Heping District, Shenyang, 110004, China
    Sleep Breath 19:561-8. 2015
    ....
  73. doi Differential expression of HIF-1α, AQP-1, and VEGF under acute hypoxic conditions in the non-ventilated lung of a one-lung ventilation rat model
    Fei Lin
    Department of Anesthesiology, Affiliated Cancer Hospital, Guangxi Medical University, Nanning, China
    Life Sci 124:50-5. 2015
    ..Therefore, in the present study, these moieties were investigated in an OLV rat model...
  74. ncbi [miR-199a-5p inhibits the proliferation of rat airway smooth muscle cells and the expression of hypoxia inducible factor 1 alpha under hypoxia conditions]
    Hui Zhang
    Department of Respiratory Medicine, Hospital Affiliated to Xuzhou Medical College, Xuzhou 221006, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 31:1183-8. 2015
    To investigate the expression of miR-199a-5p in airway smooth muscle cells (ASMCs) of rats in normoxia and hypoxia and its role in the regulation of proliferation and the expression of hypoxia inducible factor 1 alpha (HIF-1α) of ASMCs.
  75. ncbi Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene
    Kathryn A Ziel
    Department of Pharmacology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    FASEB J 18:986-8. 2004
    ....
  76. ncbi Mechanisms of hyperbaric oxygen-induced neuroprotection in a rat model of subarachnoid hemorrhage
    Robert P Ostrowski
    Department of Physiology, Loma Linda University, Loma Linda, California, USA
    J Cereb Blood Flow Metab 25:554-71. 2005
    ..HBO reduced early brain injury after SAH, probably by inhibition of HIF-1alpha and its target genes, which led to the decrease of apoptosis and preservation of the blood-brain barrier function...
  77. ncbi Age-related changes in adrenomedullin expression and hypoxia-inducible factor-1 activity in the rat lung and their responses to hypoxia
    Isabel S S Hwang
    Department of Physiology, Faculty of Medicine, University of Hong Kong, Pokfulam, China
    J Gerontol A Biol Sci Med Sci 62:41-9. 2007
    ..Thus, the HIF-AM pathway may be impaired in the aged lung, and other mechanisms may be present to maintain an AM response to hypoxia...
  78. ncbi Erythropoietin protects the kidneys against ischemia reperfusion injury by activating hypoxia inducible factor-1alpha
    Ryoich Imamura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Transplantation 83:1371-9. 2007
    ..Erythropoietin (EPO) has been shown to have a cytoprotective effect against hypoxia. We examined the effect of EPO against renal I/R injury and the underlying mechanism...
  79. pmc Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-
    Hena Alam
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Endocrinology 150:915-28. 2009
    ..Thus, regulation of HIF-1 activity in GCs by FSH under normoxic conditions is complex and requires input from multiple signaling pathways...
  80. pmc Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1 alpha) expression in serous ovarian cancer: an immunohistochemical study
    Alexandros Daponte
    Department of Obstetrics and Gynaecology, University of Thessalia, Larissa, Greece
    BMC Cancer 8:335. 2008
    ..Our study was designed to investigate this by including a comparatively large number of cases and by using a combination of antibodies to analyze immunohistochemically the expression of HIF-1 alpha...
  81. pmc Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
    Shweta Rane
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Division of Nephrology, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Circ Res 104:879-86. 2009
    ..In addition, the data demonstrate a functional link between 2 key molecules that regulate hypoxia preconditioning and longevity...
  82. pmc Hypoxia inducible factor-1α (HIF-1α) and some HIF-1 target genes are elevated in experimental glaucoma
    Ceren Ergorul
    Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    J Mol Neurosci 42:183-91. 2010
    ..These data support the hypothesis that HIF-1alpha becomes transcriptionally active in astrocytes and Müller cells but not microglia or neurons in glaucoma, arguing against a global hypoxia stimulus to the retina...
  83. ncbi [Sequential expression of hypoxia-inducible factor 1alpha and its significance in secondary spinal cord injury]
    Qingfei Niu
    Department of Orthopedic Surgery, Fengtian Hospital Affiliated to Shenyang Medical College, Shenyang Liaoning, 110024, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 25:91-5. 2011
    ..To investigate the expression pattern of hypoxia-inducible factor 1alpha (HIF-1alpha) in experimental secondary spinal cord injury (SSCI) in rats and its potential effects on SSCI...
  84. pmc Constitutive HIF-1α expression blunts the beneficial effects of cardiosphere-derived cell therapy in the heart by altering paracrine factor balance
    Michael Bonios
    Johns Hopkins University, Baltimore, MD 21205, USA
    J Cardiovasc Transl Res 4:363-72. 2011
    ..HIF-1α expression in CDCs blunted the beneficial functional effects of CDC transplantation, suggesting that paracrine factor balance may play an important role in cardiac regeneration...
  85. pmc HIF1α and pancreatic β-cell development
    Mylène Heinis
    Institut National de Santé et de Recherche Médicale INSERM U845, Research Center Growth and Signalling, Universite Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, Paris, France
    FASEB J 26:2734-42. 2012
    ..5 fold, P<0.05, and 6.6-fold, P<0.001, respectively). Taken together, these data demonstrate that HIF1α exerts a negative control over β-cell differentiation...
  86. pmc pPKCα mediated-HIF-1α activation related to the morphological modifications occurring in neonatal myocardial tissue in response to severe and mild hyperoxia
    S Zara
    Section of Human Anatomy, Faculty of Pharmacy, University G D Annunzio Chieti Pescara, Via dei Vestini 31, 66100 Chieti, Italy
    Eur J Histochem 56:e2. 2012
    ..This intracellular signalling can switch molecular events leading to blood vessels development in parallel to pro-apoptotic events due to an immature anti-oxidant defensive system in newborn rat hearts...
  87. doi Impaired biomechanical properties correlate with neoangiogenesis as well as VEGF and MMP-3 expression during rat patellar tendon healing
    Hacer Sahin
    Department of Trauma, Hand and Reconstructive Surgery, WWU Muenster, Germany
    J Orthop Res 30:1952-7. 2012
    ..The therapeutical modulation of neoangiogenesis by influencing the level of VEGF and MMP-3 might be a promising target for new approaches in degenerative tendon diseases. 30:1952-1957, 2012...
  88. doi Pathogenic role of HIF-1α in prostate hyperplasia in the presence of chronic inflammation
    Hye Jin Kim
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
    Biochim Biophys Acta 1832:183-94. 2013
    ..Based on these results, we propose that HIF-1α mediates prostate enlargement under inflammatory conditions, and we suggest that HIF-1α be viewed as a promising target for blocking the transition from prostatitis to BPH...
  89. doi Astrocyte responses to injury: VEGF simultaneously modulates cell death and proliferation
    Nicole Schmid-Brunclik
    Institute of Veterinary Physiology, Vetsuisse Faculty, Univ of Zurich, Winterthurerstrasse 260, Zurich CH 8057, Switzerland
    Am J Physiol Regul Integr Comp Physiol 295:R864-73. 2008
    ..These data suggest Hif-1 only partially contributes to VEGF-mediated astrocyte responses during chronic injury (as occurs in clinical hypoxic/ischemic insults) that may ultimately be responsible for disrupting BBB integrity...
  90. pmc Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species
    David A Patten
    Centre de recherche du CHUQ, L Hôtel Dieu de Québec, Department of Molecular Biology, Medical Biochemistry and Pathology, Universite Laval, Quebec, QC, G1R 2J6, Canada
    Mol Biol Cell 21:3247-57. 2010
    ..However, our work points to mitochondrial-generated ROS as essential intermediates for HIF-1 activation in nonhypoxic conditions...
  91. doi 2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury
    Yan Feng Wang
    The First Affiliated Hospital, China Medical University, Department of Orthopaedics, the Nanjing Bei Street No 155, Heping District, Shen Yang, Liaoning Province 110001, PR China
    Brain Res 1370:220-6. 2011
    ..And the inhibitor of HIF-1α is a novel promising therapeutic agent for human SCI-induced edema in the future...
  92. ncbi [The cooperation of OS-9 and PHDs in hypoxia-induced pulmonary hypertension of rats]
    Kun Pan
    Department of Respiratory Medicine, Hunan Institute of Gerontology, Hunan Province Geriatric Hospital, Changsha 410001, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 25:1-6. 2009
    ..To investigate the dynamic expression of hypoxia-inducible factor 1alpha, PHDs and OS-9 in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension...
  93. ncbi Hypoxia-inducible factor-1α contributes to brain edema after stroke by regulating aquaporins and glycerol distribution in brain
    Tetsuhiro Higashida
    Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Curr Neurovasc Res 8:44-51. 2011
    ..Pharmacological blockade of this pathway in stroke patients may provide novel therapeutic strategies...
  94. doi Methylseleninic acid downregulates hypoxia-inducible factor-1α in invasive prostate cancer
    Indu Sinha
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
    Int J Cancer 130:1430-9. 2012
    ..Our study illustrates the efficacy of MSeA in controlling growth of hormone refractory prostate cancer by downregulating HIF-1α, which is possibly occurring through stabilization or increase in prolyl hydroxylase activity...
  95. ncbi Gastric ulcers induced by systemic hypoxia
    Ari F Syam
    Department of Internal Medicine, Faculty of Medicine, University of Indonesia Dr Cipto Mangunkusumo Hospital, Jakarta Pusat, Indonesia
    Acta Med Indones 43:243-8. 2011
    ..to assess the effect of systemic hypoxia on gastric mucosa and the activation of stress-responsive transcription factors induced by hypoxia...
  96. doi Regulation of S100A4 expression via the JAK2-STAT3 pathway in rhomboid-phenotype pulmonary arterial smooth muscle cells exposure to hypoxia
    Ting Liu
    Institute of Respiratory Diseases, the Second Affiliated Hospital of the Third Military Medical University, Chongqing 400037, PR China
    Int J Biochem Cell Biol 44:1337-45. 2012
    ..These results suggest that JAK2-STAT3 and HIF-1α could serve as targets for the regulation of phenotype modulation of PASMCs during the process of pulmonary vessel lesions...
  97. pmc Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver
    T Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Humboldtallee 23, D 37073 Gottingen, Germany
    Biochem J 354:531-7. 2001
    ..The mRNAs of the rat HIF alpha-subunits were expressed predominantly in the perivenous zone of rat liver tissue; the nuclear HIFalpha proteins, however, did not appear to be zonated...
  98. ncbi Coexistence of hypercholesterolemia and hypertension impairs adventitial vascularization
    Hisashi Kai
    Cardiovascular Research Institute and Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    Hypertension 39:455-9. 2002
    ..Our findings provide an insight into the mechanism of the aggravation of arteriosclerosis when both hypercholesterolemia and hypertension are present...
  99. pmc Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF
    Vassiliki Poulaki
    Laboratory of Surgical Research, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 109:805-15. 2002
    ..To our knowledge, these data are the first to identify a specific mechanism for the transient worsening of diabetic retinopathy, specifically blood-retinal barrier breakdown, that follows the institution of intensive insulin therapy...
  100. ncbi Hypoxia-inducible factor-1alpha accumulation in the rat brain in response to hypoxia and ischemia is attenuated during aging
    Juan C Chavez
    Case Western Reserve University, Department of Anatomy, Cleveland, OH 44106 4938, USA
    Adv Exp Med Biol 510:337-41. 2003
  101. ncbi Hypoxia-inducible factor and nuclear factor kappa-B activation in blood-brain barrier endothelium under hypoxic/reoxygenation stress
    Ken A Witt
    Department of Pharmacology, University of Arizona, College of Medicine, Arizona 85724, USA
    J Neurochem 92:203-14. 2005
    ..These data offer novel avenues in which to alter and/or investigate BBB activity across model systems and to further our understanding of upstream regulators during hypoxia and H/R...

Research Grants11

  1. Is There a Link Between Alzheimer's and Atheroclerosis
    Paula Grammas; Fiscal Year: 2007
    ..abstract_text> ..
  2. Vascular inflammation and neurotoxicity in aging brain
    Paula Grammas; Fiscal Year: 2009
    ....
  3. Hypoxia and the Role of HIF-1 in the Ischemic Testis
    Michael Palladino; Fiscal Year: 2005
    ..abstract_text> ..
  4. PERIPHERAL CHEMORECEPTORS: MECHANISMS & MODULATIONS
    Sukhamay Lahiri; Fiscal Year: 2003
    ..The aim of this proposal is to understand how the processes are initiated in the chemosensory cells. ..
  5. PHYSIOLOGY OF NERVE, GLIAL AND MUSCLE CELL LINES
    David Schubert; Fiscal Year: 2005
    ..This work is directly relevant to CNS trauma and stroke as well as to all chronic degenerative diseases where oxidative stress is a pathological hallmark. ..
  6. Redox Sensitive Proteins in Aging and Neurodegeneration
    David Schubert; Fiscal Year: 2006
    ..These proteins, in turn, will be used as targets for the identification of potentially therapeutic antioxidants that could be useful in preventing age-and disease-associated damage to the CNS. ..
  7. Development and Testing of a Novel Neuroprotective Drug
    David Schubert; Fiscal Year: 2006
    ..The results from these studies will determine the therapeutic potential of this novel compound. [unreadable] [unreadable]..
  8. Regulation of APP Degradation and ABeta Secretion
    David Schubert; Fiscal Year: 2008
    ..In addition, understanding how cells regulate the degradation of proteins is critical to the study of a wide range of diseases, particularly those in the nervous system that are characterized by the intracellular protein accumulation. ..
  9. A Novel Family of Neuroprotective Compounds for Stroke
    DAVID R SCHUBERT; Fiscal Year: 2010
    ..abstract_text> ..