Hcrtr1

Summary

Gene Symbol: Hcrtr1
Description: hypocretin receptor 1
Alias: Hctr1, orexin receptor type 1, hypocretin (orexin) receptor 1, hypocretin receptor type 1, ox-1-R, ox1-R, ox1r
Species: rat

Top Publications

  1. ncbi Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    T Sakurai
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 92:573-85. 1998
  2. ncbi Physiological regulation and NO-dependent inhibition of migrating myoelectric complex in the rat small bowel by OXA
    M Ehrström
    Division of Surgery, Danderyd Hospital, Stockholm, Sweden
    Am J Physiol Gastrointest Liver Physiol 285:G688-95. 2003
  3. doi Orexin-A promotes Glu uptake by OX1R/PKCα/ERK1/2/GLT-1 pathway in astrocytes and protects co-cultured astrocytes and neurons against apoptosis in anoxia/hypoglycemic injury in vitro
    Qing Shu
    Department of Pharmacy, Ninth Hospital of Xi an, No 151 South Second Ring Road East, Xi an, 710054, Shaanxi, China
    Mol Cell Biochem 425:103-112. 2017
  4. ncbi Orexins/hypocretins stimulate accumulation of inositol phosphate in primary cultures of rat cortical neurons
    Jolanta B Zawilska
    Institute for Medical Biology, Polish Academy of Sciences, Lodowa 106, PL 93 232 Łódź, Poland
    Pharmacol Rep 65:513-6. 2013
  5. pmc Hindbrain orexin 1 receptors influence palatable food intake, operant responding for food, and food-conditioned place preference in rats
    Kristen Kay
    Department of Psychology and Program in Neuroscience, Florida State University, Box 3064301, Tallahassee, FL, 32306 4301, USA
    Psychopharmacology (Berl) 231:419-27. 2014
  6. doi Central orexin inhibits reflex swallowing elicited by the superior laryngeal nerve via caudal brainstem in the rat
    Motoi Kobashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8525, Japan Electronic address
    Physiol Behav 130:6-12. 2014
  7. doi Orexin A protects cells from apoptosis by regulating FoxO1 and mTORC1 through the OX1R/PI3K/AKT signaling pathway in hepatocytes
    Shu Jing Ju
    Department of Endocrinology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P R China
    Int J Mol Med 34:153-9. 2014
  8. pmc Role of orexin/hypocretin in conditioned sucrose-seeking in female rats
    Angie M Cason
    Department of Neurosciences, Medical University of South Carolina, Basic Science Building 406, 173 Ashley Avenue, MSC 510, Charleston, SC 29425, USA Electronic address
    Neuropharmacology 86:97-102. 2014
  9. doi Orexin-1 receptor antagonist in central nucleus of the amygdala attenuates the acquisition of flavor-taste preference in rats
    Severiano Risco
    Departamento de Farmacologia, Facultad de Farmacia, Campus de Cartuja, Universidad de Granada, 18071 Granada, Spain
    Pharmacol Biochem Behav 126:7-12. 2014
  10. doi Orexin excites rat inferior vestibular nuclear neurons via co-activation of OX1 and OX 2 receptors
    Lei Yu
    State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology, School of Life Sciences, Nanjing University, Mailbox 426, 22 Hankou Road, Nanjing, 210093, China
    J Neural Transm (Vienna) 122:747-55. 2015

Research Grants

  1. Orexinergic Pathways in Central Autonomic Control
    WILLIS SAMSON; Fiscal Year: 2005
  2. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    Willis K Samson; Fiscal Year: 2010

Scientific Experts

  • J T Willie
  • Motoi Kobashi
  • Qing Shu
  • Angie M Cason
  • Jolanta B Zawilska
  • Rachel J Smith
  • WILLIS SAMSON
  • Denys V Volgin
  • T Sakurai
  • Afsaneh Eliassi
  • E Molik
  • Stephanie L Borgland
  • Lichao Chen
  • M I Smith
  • K Dohi
  • K W Nowak
  • Ernest Adeghate
  • Monique Caillol
  • Esmaeil Akbari
  • Magnus W Bengtsson
  • Patricia Silveyra
  • Kristen Kay
  • Eric M Parise
  • Agnieszka Ziolkowska
  • Simona Tafuri
  • Robyn Mary Brown
  • Lei Yu
  • Jing Jing Zhou
  • Ying Jun Zhong
  • Ramin Raoof
  • Takeshi Iwasa
  • Fei Zhu
  • Badr Mostafa Ibrahim
  • Olaf Jöhren
  • Severiano Risco
  • Shu Jing Ju
  • Nicole Lilly
  • Diana L Williams
  • Laura Piccoli
  • Loredana Assisi
  • Luyi Zhou
  • Kaja Biegańska
  • Daniel E Rusyniak
  • Lei Tian
  • Alfredo Vittoria
  • Norma Staiano
  • Paul J Kenny
  • Jian Lian Guan
  • Hossein Azizi
  • Michael D Cameron
  • Mark G LeSage
  • Y Jeong
  • Fereshteh Motamedi
  • S G Nair
  • Kari Mäkelä
  • Karl Heinz Herzig
  • Jonathan A Hollander
  • Carlos Libertun
  • Gunnar Flemström
  • Victoria Lux-Lantos
  • Tatiana Gorojankina
  • Sachin Paranjape
  • Gastone G Nussdorfer
  • Roland Salesse
  • Ludwik K Malendowicz
  • J A Teske
  • Cinzia Tortorella
  • Vânia D'Almeida
  • Alexandre B Hardy
  • M L Barreiro
  • Frank Desarnaud
  • M Ehrström
  • Yun Zhu
  • Shaun Yon Seng Khoo
  • Rebecca E Campbell
  • Andrew John Lawrence
  • Seiji Shioda
  • Jee Hyun Kim
  • Andrezza K Kim
  • Bianca Jupp
  • Akira Kuwahara
  • Saeed Esmaeili-Mahani
  • Jia Tang Zhang
  • Yi Zhang
  • Qian Xing Zhuang
  • Abdel A Abdel-Rahman
  • Ladan Amirkhosravi
  • Sen Yang Lang
  • Munkhsaikhan Munkhzaya
  • Xiang qing Wang

Detail Information

Publications69

  1. ncbi Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    T Sakurai
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 92:573-85. 1998
    ..prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior...
  2. ncbi Physiological regulation and NO-dependent inhibition of migrating myoelectric complex in the rat small bowel by OXA
    M Ehrström
    Division of Surgery, Danderyd Hospital, Stockholm, Sweden
    Am J Physiol Gastrointest Liver Physiol 285:G688-95. 2003
    ..Naive rats were given a bolus of the orexin receptor-1 (OX1R) antagonist (SB-334867-A; 10 mg/kg), and the effect of both OXA and SB-334867-A on fasting motility was studied...
  3. doi Orexin-A promotes Glu uptake by OX1R/PKCα/ERK1/2/GLT-1 pathway in astrocytes and protects co-cultured astrocytes and neurons against apoptosis in anoxia/hypoglycemic injury in vitro
    Qing Shu
    Department of Pharmacy, Ninth Hospital of Xi an, No 151 South Second Ring Road East, Xi an, 710054, Shaanxi, China
    Mol Cell Biochem 425:103-112. 2017
    ..However, these effects were significantly weakened by treatment with orexin-A receptor 1 (OX1R) antagonist...
  4. ncbi Orexins/hypocretins stimulate accumulation of inositol phosphate in primary cultures of rat cortical neurons
    Jolanta B Zawilska
    Institute for Medical Biology, Polish Academy of Sciences, Lodowa 106, PL 93 232 Łódź, Poland
    Pharmacol Rep 65:513-6. 2013
    ..They signal through two G protein-coupled receptors: OX1R and OX2R...
  5. pmc Hindbrain orexin 1 receptors influence palatable food intake, operant responding for food, and food-conditioned place preference in rats
    Kristen Kay
    Department of Psychology and Program in Neuroscience, Florida State University, Box 3064301, Tallahassee, FL, 32306 4301, USA
    Psychopharmacology (Berl) 231:419-27. 2014
    Brain orexin 1 receptors (OX1Rs) are involved in food-motivated behavior. Most research has focused on forebrain OX1R populations, but hindbrain OX1Rs affect feeding. We hypothesized that hindbrain OX1Rs affect the reward value of food.
  6. doi Central orexin inhibits reflex swallowing elicited by the superior laryngeal nerve via caudal brainstem in the rat
    Motoi Kobashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8525, Japan Electronic address
    Physiol Behav 130:6-12. 2014
    ..These results suggest that orexin-A inhibits reflex swallowing via orexin-1 receptors situated in the commissural part of the NTS and/or its vicinity. ..
  7. doi Orexin A protects cells from apoptosis by regulating FoxO1 and mTORC1 through the OX1R/PI3K/AKT signaling pathway in hepatocytes
    Shu Jing Ju
    Department of Endocrinology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P R China
    Int J Mol Med 34:153-9. 2014
    ..They signal through two G-protein‑coupled receptors (GPCR): orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R)...
  8. pmc Role of orexin/hypocretin in conditioned sucrose-seeking in female rats
    Angie M Cason
    Department of Neurosciences, Medical University of South Carolina, Basic Science Building 406, 173 Ashley Avenue, MSC 510, Charleston, SC 29425, USA Electronic address
    Neuropharmacology 86:97-102. 2014
    ....
  9. doi Orexin-1 receptor antagonist in central nucleus of the amygdala attenuates the acquisition of flavor-taste preference in rats
    Severiano Risco
    Departamento de Farmacologia, Facultad de Farmacia, Campus de Cartuja, Universidad de Granada, 18071 Granada, Spain
    Pharmacol Biochem Behav 126:7-12. 2014
    ..demonstrated that the intracerebroventricular administration of SB-334867-A, a selective antagonist of orexin OX1R receptors, blocks the acquisition of saccharin-induced conditioned flavor preference (CFP) but not LiCl-induced ..
  10. doi Orexin excites rat inferior vestibular nuclear neurons via co-activation of OX1 and OX 2 receptors
    Lei Yu
    State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology, School of Life Sciences, Nanjing University, Mailbox 426, 22 Hankou Road, Nanjing, 210093, China
    J Neural Transm (Vienna) 122:747-55. 2015
    ....
  11. doi Changes and overlapping distribution in the expression of CB1/OX1-GPCRs in rat hippocampus by kainic acid-induced status epilepticus
    Fei Zhu
    Department of Neurology, Chinese PLA General Hospital, No 28, FuXing Road, Beijing 100853, China
    Brain Res 1597:14-27. 2015
    ..The overlapping distribution of CB1 and OX1 in the hippocampus indicates that they may form a heterodimer to exert their effect in epilepsy. ..
  12. doi Changes in hippocampal orexin 1 receptor expression involved in tooth pain-induced learning and memory impairment in rats
    Ramin Raoof
    Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran Laboratory of Molecular Neuroscience, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
    Neuropeptides 50:9-16. 2015
    ..Meanwhile, reversed changes took place in the ibuprofen-pretreated group (p < 0.05). It seems that decrease in orexin 1 receptor density and signaling could be involved in tooth pain-induced learning and memory impairment...
  13. doi Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in iP rats
    Robyn Mary Brown
    Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia
    Addict Biol 21:603-12. 2016
    ..These findings suggest that OX1 receptors located in the prelimbic cortex and ventral tegmental area are part of a circuit driving cue-mediated ethanol-seeking behaviour. ..
  14. doi Wake-promoting actions of median nerve stimulation in TBI-induced coma: An investigation of orexin-A and orexin receptor 1 in the hypothalamic region
    Ying Jun Zhong
    Department of Rehabilitation, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P R China
    Mol Med Rep 12:4441-7. 2015
    ..The expression levels of orexin‑A and orexin receptor‑1 (OX1R) in the hypothalamus were examined using immunohistochemistry, western blotting and an enzyme‑linked ..
  15. pmc A pivotal role for enhanced brainstem Orexin receptor 1 signaling in the central cannabinoid receptor 1-mediated pressor response in conscious rats
    Badr Mostafa Ibrahim
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, 600 Moye Boulevard, Greenville, NC 27858, United States
    Brain Res 1622:51-63. 2015
    Orexin receptor 1 (OX1R) signaling is implicated in cannabinoid receptor 1 (CB1R) modulation of feeding...
  16. pmc Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats
    Jing Jing Zhou
    Department of Physiology, Hebei Medical University, Shijiazhuang, Hebei 050017, China Department of Critical Care, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Neuropharmacology 99:481-90. 2015
    ..Microinjection of orexin 1 receptor (OX1R) antagonist SB334867 into the PVN reduced basal arterial blood pressure (ABP) and renal sympathetic nerve activity (..
  17. doi Developmental changes in the hypothalamic mRNA levels of prepro-orexin and orexin receptors and their sensitivity to fasting in male and female rats
    Takeshi Iwasa
    Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan Electronic address
    Int J Dev Neurosci 46:51-4. 2015
    ..The developmental changes in the hypothalamic mRNA levels of pp-prexin and the orexin receptors OX1R and OX2R and their sensitivity to fasting were evaluated in both male and female rats...
  18. pmc Role of orexin-1 receptor mechanisms on compulsive food consumption in a model of binge eating in female rats
    Laura Piccoli
    GlaxoSmithKline, Medicines Research Centre, Verona, Italy
    Neuropsychopharmacology 37:1999-2011. 2012
    ....
  19. pmc Evidence for the role of hindbrain orexin-1 receptors in the control of meal size
    Eric M Parise
    Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 4301, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1692-9. 2011
    ..Therefore, hindbrain orexin-A may increase food intake, in part, by reducing the ability of rats to respond to amylin during a meal...
  20. pmc Orexin-1 receptor mediation of cocaine seeking in male and female rats
    Luyi Zhou
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 340:801-9. 2012
    ..weight 250-300 g) and female (initial weight 175-225 g) Sprague-Dawley rats by using the orexin-1 receptor (OX1R) antagonist 1-(2-methylbenzoxazol-6-yl)-3-[1,5]naphthyridin-4-yl urea (SB-334867) (10-30 mg/kg)...
  21. pmc Orexin / hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking
    Rachel J Smith
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Eur J Neurosci 35:798-804. 2012
    ..These results indicate that orexin antagonism reduces heroin self-administration, and they support a role for orexin in cue-triggered drug relapse...
  22. doi Expression and role of receptor 1 for orexins in seminiferous tubules of rat testis
    Loredana Assisi
    Department of Biological Sciences, University of Naples Federico II, Naples, Italy
    Cell Tissue Res 348:601-7. 2012
    Orexins (OxA and OxB) and their receptors (Ox1R and Ox2R), originally detected in the hypothalamus, have also been localized in multiple cerebral areas and peripheral organs...
  23. pmc Orexin A suppresses the growth of rat C6 glioma cells via a caspase-dependent mechanism
    Kaja Biegańska
    Institute for Medical Biology, Polish Academy of Sciences, 93 232 Lodz, Poland
    J Mol Neurosci 48:706-12. 2012
    ..In addition to that, a parallel increase in caspase-3 activity was observed. It is suggested that stimulation of orexin receptors induces death of rat C6 glioma cells through activation of caspase pathway...
  24. doi Expression of orexin A and its receptor 1 in the rat epididymis
    Simona Tafuri
    Department of Biological Structures, Functions and Technologies, University of Naples Federico II, Via F Delpino 1, 80137 Naples, Italy
    Regul Pept 155:1-5. 2009
    ..It binds with the high affinity G-protein-coupled orexin receptor 1 (OX1R)...
  25. pmc The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neurosci Lett 498:162-6. 2011
    ....
  26. ncbi [Expression of orexin receptor 1 in rat pancreatic tissue with alimentary obesity]
    Lei Tian
    Department of Endocrinology, First Clinical Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Yi Xue Za Zhi 91:409-11. 2011
    ..To identify the presence of orexin receptor 1 (OXR1) in obese rat pancreas and clarify its effect and mechanism on body weight and metabolic index in obese rats...
  27. pmc Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period
    Lichao Chen
    Research Service, VA Boston Healthcare System, and Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Eur J Neurosci 32:1528-36. 2010
    ..The results indicate that a modest knockdown of OxR1 is sufficient to induce observable sleep changes. Moreover, orexin neurons, by acting on OxR1 in the LC, play a role in the diurnal gating of REM sleep...
  28. doi Orexin-1 receptor mediates long-term potentiation in the dentate gyrus area of freely moving rats
    Esmaeil Akbari
    Department of Physiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
    Behav Brain Res 216:375-80. 2011
    ..and orexin B act as endogenous ligands for two G-protein coupled receptors called orexin-1 and orexin-2 receptors (OX1R and OX2R). In the dentate gyrus (DG) region, OX1R, which has high affinity for orexin A, is expressed...
  29. doi Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats
    Hossein Azizi
    Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, PO Box 14115 331, Tehran, IR, Iran
    Neurosci Lett 482:255-9. 2010
    ..These results suggest that activation of OXR1 in the LC might be involved in the expression of withdrawal signs in morphine dependent rats...
  30. pmc Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 S 8th Street, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 209:203-12. 2010
    ..The hypocretin (hcrt) system has been implicated in addiction-relevant effects of several drugs, but its role in nicotine dependence has been little studied...
  31. pmc Orexin-1 receptor co-localizes with pancreatic hormones in islet cells and modulates the outcome of streptozotocin-induced diabetes mellitus
    Ernest Adeghate
    Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    PLoS ONE 5:e8587. 2010
    ..This study examined the pattern of distribution of orexin-1 receptor (OX1R) in the endocrine cells of the pancreas of normal and diabetic Wistar (a model of type 1 diabetes), Goto-Kakizaki (..
  32. pmc Orexin receptor subtype activation and locomotor behaviour in the rat
    W K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63131, USA
    Acta Physiol (Oxf) 198:313-24. 2010
    ..We describe here the ability of orexin to increase locomotor behaviours and identify the importance of both receptor subtypes in these actions...
  33. pmc Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers
    Stephanie L Borgland
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
    J Neurosci 29:11215-25. 2009
    ....
  34. doi Gonadal steroids modulated hypocretin/orexin type-1 receptor expression in a brain region, sex and daytime specific manner
    Patricia Silveyra
    Instituto de Biologia y Medicina Experimental CONICET, Argentina
    Regul Pept 158:121-6. 2009
    ..Sexual steroids modulate the orexinergic system and the anatomical regions, hormones and times of the day all have to be considered when the roles of orexins, and probably other peptides, are under consideration...
  35. pmc Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking
    Rachel J Smith
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425 5100, USA
    Eur J Neurosci 30:493-503. 2009
    ....
  36. pmc Dorsomedial pontine neurons with descending projections to the medullary reticular formation express orexin-1 and adrenergic alpha2A receptor mRNA
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurosci Lett 459:115-8. 2009
    ..Our data suggest that ORX and adrenergic pathways converge on a subpopulation of cells of the pontine REM sleep-triggering region that have descending projections to the medullary region important for the motor control during REM sleep...
  37. ncbi Gonadotropin-releasing hormone neurons coexpress orexin 1 receptor immunoreactivity and receive direct contacts by orexin fibers
    Rebecca E Campbell
    Department of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    Endocrinology 144:1542-8. 2003
    ..Together, these data suggest that Y4 receptor modulation of LH release is likely to be indirect through orexin cell bodies and that orexin modulates GnRH neurons directly via OX-R1...
  38. ncbi Orexin A modulates mitral cell activity in the rat olfactory bulb: patch-clamp study on slices and immunocytochemical localization of orexin receptors
    Alexandre B Hardy
    Laboratoire de Neurosciences et Systèmes Sensoriels, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5020, Universite Claude Bernard, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
    Endocrinology 146:4042-53. 2005
    ..Our results provide data that should allow us to better understand neural communication and regulation mechanisms between the hypothalamic feeding centers and the olfactory bulb...
  39. ncbi Opposite effects of sleep rebound on orexin OX1 and OX2 receptor expression in rat brain
    Vânia D'Almeida
    Department of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Brain Res Mol Brain Res 136:148-57. 2005
    ..study examined the effects of sleep deprivation (SD) and sleep recovery on the expression of orexin 1 receptors (OX1R) and orexin 2 receptors (OX2R) throughout the brain...
  40. ncbi Evidence that orexins A and B stimulate insulin secretion from rat pancreatic islets via both receptor subtypes
    Krzysztof W Nowak
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Poznan, Poland
    Int J Mol Med 15:969-72. 2005
    ..66 or 26.4 mmol/l), with orexin A being more potent than orexin B. This study demonstrates that orexins A and B modulate insulin secretion in vitro...
  41. pmc The diurnal rhythm of hypocretin in young and old F344 rats
    Frank Desarnaud
    West Roxbury Veterans Affairs Medical Center and Harvard Medical School, Mass 02132, USA
    Sleep 27:851-6. 2004
    ..In young rats and monkeys, levels of HCRT-1 are highest at the end of the wake-active period and lowest toward the end of the sleep period. However, the effects of age on the diurnal rhythm of HCRT-1 are not known...
  42. ncbi Ultrastructure of orexin-1 receptor immunoreactivities in the spinal cord dorsal horn
    Jian Lian Guan
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Peptides 25:1307-11. 2004
    The ultrastructural properties of orexin 1-receptor-like immunoreactive (OX1R-LI) neurons in the dorsal horn of the rat spinal cord were examined using light and electron microscopy techniques...
  43. ncbi Orexin 1 receptor messenger ribonucleic acid expression and stimulation of testosterone secretion by orexin-A in rat testis
    M L Barreiro
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain
    Endocrinology 145:2297-306. 2004
    ..Overall, our data are suggestive of a novel site of action of orexins in the control of male reproductive axis...
  44. ncbi Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins
    Yun Zhu
    Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan
    J Pharmacol Sci 92:259-66. 2003
    ..pathways of orexin receptors were examined using a nerve-like cell line transfected with orexin receptor type-1 (OX1R) and orexin receptor type-2 (OX2R)...
  45. ncbi Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat
    M I Smith
    Neurology CEDD, GlaxoSmithKline, New Frontiers Science Park North, Third Avenue, Harlow, Essex, UK, CM19 5AW
    Neurosci Lett 341:256-8. 2003
    ..Orexin-A administration reduced the amount and increased the latency to onset of PS. SB-334867-A reversed this effect of orexin-A. The present study demonstrates that the OX(1)R also has a role in orexinergic sleep modulation...
  46. ncbi Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 receptor
    Agnieszka Ziolkowska
    Department of Histology and Embryology, Poznan School of Medicine, PL 60781 Poznan, Poland
    J Steroid Biochem Mol Biol 96:423-9. 2005
    ....
  47. ncbi Gonadal steroids differentially regulate the messenger ribonucleic acid expression of pituitary orexin type 1 receptors and adrenal orexin type 2 receptors
    Olaf Jöhren
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Clinic Lübeck, D 23538 Lubeck, Germany
    Endocrinology 144:1219-25. 2003
    ....
  48. ncbi Localization of orexins and their receptors in the rat olfactory system: possible modulation of olfactory perception by a neuropeptide synthetized centrally or locally
    Monique Caillol
    Laboratoire de Biologie Cellulaire et Moleculaire, Récepteurs et Communication Cellulaire, INRA, 78352, Jouy en Josas, France
    Brain Res 960:48-61. 2003
    ..They suggest a possible modulation of olfactory perception by these neuropeptides...
  49. ncbi Orexin-1 receptor immunoreactivity in chemically identified target neurons in the rat hypothalamus
    Ryusuke Suzuki
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Neurosci Lett 324:5-8. 2002
    ..Strong orexin receptor 1 (OX1R) immunoreactivity was detected in the hypothalamus including the arcuate, ventromedial, and tuberomammillary nuclei ..
  50. ncbi The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor
    Heike A Wieland
    Division of Preclinical Research, Boehringer Ingelheim Pharma KG, Biberach, Germany
    Eur J Biochem 269:1128-35. 2002
    ..Amino acid prediction of this A -->G change results in an isoleucine --> valine substitution at the protein level, which may provide evidence for an editing process...
  51. ncbi Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake
    Matilda Bäckberg
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Eur J Neurosci 15:315-28. 2002
    ..The results support the idea that orexins have important actions on hypothalamic neurons that control food intake and fluid balance, but also that orexins may regulate other neuroendocrine systems...
  52. ncbi Hypocretin/orexin, sleep and narcolepsy
    M Hungs
    Stanford Center for Narcolepsy, Department of Psychiatry Behavioral Sciences, Stanford University Medical Center, Palo Alto, CA 94305 5485, USA
    Bioessays 23:397-408. 2001
    ..Two known receptors, Hcrtr1 and Hcrtr2, have been reported...
  53. ncbi To eat or to sleep? Orexin in the regulation of feeding and wakefulness
    J T Willie
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 75390 9050, USA
    Annu Rev Neurosci 24:429-58. 2001
    ....
  54. pmc The role of spinal orexin-1 receptors in posterior hypothalamic modulation of neuropathic pain
    Y Jeong
    Kyunghee University, Dongdaemun Gu, Seoul, Korea, ROK
    Neuroscience 159:1414-21. 2009
    ..These data are suggestive that stimulating the PH produces antinociception in a neuropathic pain model and that the antinociceptive effect is mediated in part by orexin-1 receptors in the spinal cord dorsal horn...
  55. ncbi Elevated hypothalamic orexin signaling, sensitivity to orexin A, and spontaneous physical activity in obesity-resistant rats
    J A Teske
    Department of Food Science and Nutrition, University of Minnesota, Saint Paul, USA
    Am J Physiol Regul Integr Comp Physiol 291:R889-99. 2006
    ..that DR rats have greater: 1) basal SPA, 2) orexin A-induced SPA, and 3) preproorexin, orexin 1 and 2 receptor (OX1R and OX2R) mRNA, compared with DIO rats...
  56. ncbi Functional inactivation of orexin 1 receptors in CA1 region impairs acquisition, consolidation and retrieval in Morris water maze task
    Esmaeil Akbari
    Neuroscience Research Center and Department of Physiology, School of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Behav Brain Res 173:47-52. 2006
    ..the effect of pre-training, post-training and pre-probe trial intrahippocampal CA1 administration of a selective OX1R the orexin 1 receptor antagonist SB-334867-A (1.5, 3, 6 microg/0...
  57. ncbi CSF orexin A concentrations and expressions of the orexin-1 receptor in rat hippocampus after cardiac arrest
    Kenji Dohi
    Department of Emergency and Critical Care Medicine, School of Medicine, Showa University, Shinagawa ku, Tokyo, Japan
    Neuropeptides 40:245-50. 2006
    ..changes in cerebrospinal fluid (CSF) orexin-A concentration and the expression of the orexin-1 receptor (OX1R) in the rat hippocampus after global ischemia-reperfusion (5 min cardiopulmonary arrest), which is known to induce ..
  58. ncbi Role of dorsal vagal motor nucleus orexin-receptor-1 in glycemic responses to acute versus repeated insulin administration
    Sachin Paranjape
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, 356 Sugar Hall, 580 University Avenue, The University of Louisiana at Monroe, Monroe, LA 71209, USA
    Neuropeptides 41:111-6. 2007
    ....
  59. ncbi Study of orexins signal transduction pathways in rat olfactory mucosa and in olfactory sensory neurons-derived cell line Odora: multiple orexin signalling pathways
    Tatiana Gorojankina
    Unité de Neurobiologie de l Olfaction et de la Prise Alimentaire, UMR1197 INRA Université Paris 11, Equipe Récepteurs et Communication Chimique, CRJ, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France
    Regul Pept 141:73-85. 2007
    ..They signal through two G-protein-coupled receptors: orexin receptor 1 and 2 (Ox1R and Ox2R)...
  60. ncbi The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
    Takeshi Sakurai
    Department of Pharmacology, Institute of Basic Medical Science, University of Tsukuba, Ibaraki 305 8575, Japan
    Nat Rev Neurosci 8:171-81. 2007
    ..The orexin (hypocretin) system regulates sleep and wakefulness through interactions with systems that regulate emotion, reward and energy homeostasis...
  61. ncbi Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A
    Magnus W Bengtsson
    Dept of Neuroscience, Division of Physiology, Uppsala University, BMC, PO Box 572, SE 751 23 Uppsala, Sweden
    Am J Physiol Gastrointest Liver Physiol 293:G501-9. 2007
    ..05). We conclude that stimulation of secretion by orexin-A may involve both receptor types and is independent of cholinergic pathways. Intestinal OX receptors and secretory responses are markedly related to food intake...
  62. ncbi Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation
    Patricia Silveyra
    Instituto de Biología y Medicina Experimental Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Argentina
    Am J Physiol Endocrinol Metab 293:E977-85. 2007
    ..Two new receptor antagonists reduced proestrous gonadotropins and/or ova number while producing ovarian structural changes...
  63. ncbi Cultured rat calvarial osteoblast-like cells are provided with orexin type 1 receptors
    Agnieszka Ziolkowska
    Department of Histology and Embryology, School of Medicine, Karol Marcinkowski University of Medical Sciences, PL 60781 Poznan, Poland
    Int J Mol Med 20:779-82. 2007
    ..This novel finding suggests that rat osteoblasts could be a target for circulating orexin-A, especially during their early stages of differentiation into mature osteoblasts...
  64. pmc Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats
    S G Nair
    Behavioral Neuroscience Branch, NIDA IRP NIH DHHS, Baltimore, MD 21224, USA
    Br J Pharmacol 154:406-16. 2008
    ..However, the role of these receptors in operant food self-administration or relapse to food seeking in animal models is unknown...
  65. pmc Insular hypocretin transmission regulates nicotine reward
    Jonathan A Hollander
    Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Proc Natl Acad Sci U S A 105:19480-5. 2008
    ....
  66. doi Short food deprivation inhibits orexin receptor 1 expression and orexin-A induced intracellular calcium signaling in acutely isolated duodenal enterocytes
    Magnus W Bengtsson
    Department of Neuroscience, Division of Physiology, Uppsala University, BMC, PO Box 593, SE 751 23 Uppsala, Sweden
    Am J Physiol Gastrointest Liver Physiol 296:G651-8. 2009
    ..extracted from pellets of enterocytes and reverse transcribed to cDNA, and expression of orexin receptors 1 and 2 (OX1R and OX2R) was measured by quantitative real-time PCR...
  67. doi Role of the ventromedial hypothalamic orexin-1 receptors in regulation of gastric Acid secretion in conscious rats
    A Eliassi
    Neuroscience Research Centre and Department of Physiology, Faculty of Medicine, Shahid Beheshti University, Medical Campus, Tehran, Iran
    J Neuroendocrinol 21:177-82. 2009
    ..The orexin receptors are distributed within the hypothalamus, and expression of orexin-1 receptors (OX1R) is greatest in the anterior hypothalamus and ventromedial nucleus...
  68. ncbi The role of orexin A in the control of prolactin and growth hormone secretions in sheep--in vitro study
    E Molik
    Department of Sheep and Goat Breeding, Biotechnology and Genomic Laboratory, Agricultural University, Krakow, Poland
    J Physiol Pharmacol 59:91-100. 2008
    ..We conclude that the secretion of PRL and GH from the ovine pituitary gland is negatively responsive to orexin A during SD; whereas orexin may stimulate PRL and GH secretion during LD...

Research Grants2

  1. Orexinergic Pathways in Central Autonomic Control
    WILLIS SAMSON; Fiscal Year: 2005
    ..abstract_text> ..
  2. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    Willis K Samson; Fiscal Year: 2010
    ..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..