Hba1

Summary

Gene Symbol: Hba1
Description: hemoglobin, alpha 1
Alias: HBAM, Hba-a1, Hba-a2, hemoglobin subunit alpha-1/2, alpha-1/2-globin, hemoglobin alpha 1 chain, hemoglobin alpha, adult chain 1, hemoglobin alpha, adult chain 2, hemoglobin alpha-1/2 chain
Species: rat

Top Publications

  1. ncbi Proteomic analysis of cerebral synaptosomes isolated from rat model of alzheimer's disease
    Huiyun Yang
    Tianjin Medical University, Tianjin 300070, China
    Indian J Exp Biol 49:118-24. 2011
  2. pmc Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7
    Darja Kanduc
    CARSO Cancer Research Center, Valenzano, Regione Puglia, Italy
    J Virol 76:7040-8. 2002
  3. ncbi Hb Luxembourg [alpha 24(B5) Tyr----His]: a new unstable variant
    P Groff
    Division d Hématologie, Laboratoire National de Santé, Luxembourg
    Hemoglobin 13:429-36. 1989
  4. ncbi Increased oxygen affinity with normal heterotropic effects in hemoglobin Loire [alpha 88(F9)Ala----Ser]
    F Baklouti
    CNRS UA 1171, Faculte de Medecine Grange Blanche, Lyon, France
    Eur J Biochem 177:307-12. 1988
  5. ncbi Initiation codon mutation as a cause of alpha thalassemia
    M Pirastu
    J Biol Chem 259:12315-7. 1984
  6. ncbi Hb Aghia Sophia [alpha62(E11)Val-->0 (alpha1)], an "in-frame" deletion causing alpha-thalassemia
    J Traeger-Synodinos
    First Department of Pediatrics Aghia Sophia Children Hospital Athens University, Greece
    Hemoglobin 23:317-24. 1999
  7. ncbi Hyperunstable hemoglobin Toyama [alpha 2 136(H19)Leu----Arg beta 2]: detection and identification by in vitro biosynthesis with radioactive amino acids
    Y Ohba
    Department of Clinical Laboratory Science, Yamaguchi University School of Medicine, Ube, Japan
    Hemoglobin 11:539-56. 1987
  8. ncbi Identification of the molecular genetic defect of patients with methemoglobin M-Kankakee (M-Iwate), alpha87 (F8) His --> Tyr: evidence for an electrostatic model of alphaM hemoglobin assembly
    A Ameri
    Division of Pediatric Hematology Oncology and the Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Blood 94:1825-6. 1999
  9. ncbi Two new rat alpha-globin sequences as identified by the conserved region PCR
    V M Lam
    Department of Biochemistry, University of Hong Kong
    Hemoglobin 17:363-71. 1993
  10. pmc Neurons express hemoglobin alpha- and beta-chains in rat and human brains
    Franziska Richter
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 515:538-47. 2009

Scientific Experts

  • A Ameri
  • D Kanduc
  • Camila Squarzoni Dale
  • Huiyun Yang
  • Franziska Richter
  • Meiling Lu
  • Haixuan Qiao
  • Xin Tian
  • R Oyama
  • H Satoh
  • Chunni Zhu
  • Vera P Medvedeva
  • Marie Francoise Chesselet
  • Bernhard H Meurers
  • J Traeger-Synodinos
  • Xing Fang Li
  • Hailin Wang
  • Xiufen Lu
  • Lora L Arnold
  • Samuel M Cohen
  • X Chris Le
  • William R Cullen
  • H Yamamoto
  • T Okazaki
  • K Titani
  • C L Harteveld
  • Y Nagae
  • E Kanavakis
  • C Kattamis
  • L F Bernini
  • N Inokuchi
  • P C Giordano
  • A K Dutta-Roy
  • V M Lam
  • C G Chua
  • Y Huang
  • Y L Gu
  • P Trayhurn
  • B Dunbar
  • C W Ma
  • L Y Cheng
  • W M Wong
  • D M Au
  • M Pirastu
  • L M Garrick
  • F Baklouti
  • Y Ohba
  • M E John
  • R Crkvenjakov
  • R W Carrell
  • H Wajcman
  • P Groff
  • K Yamamoto
  • G Saglio
  • M Bucan
  • V S Sharma
  • Y W Kan
  • C Poyart
  • Y Blouquit
  • R Kawata
  • J C Chang
  • F Galacteros
  • H Fujii
  • T Miyaji
  • A Cao
  • A Savic
  • M Fogel
  • B H Howard
  • M Konstantinovic
  • M J McDonald
  • V Glisin
  • V Baudin-Chich
  • G Kalmes
  • M Marden
  • H M Ranney
  • J Kister
  • Y Hattori
  • J Delaunay
  • G Teyssier

Detail Information

Publications21

  1. ncbi Proteomic analysis of cerebral synaptosomes isolated from rat model of alzheimer's disease
    Huiyun Yang
    Tianjin Medical University, Tianjin 300070, China
    Indian J Exp Biol 49:118-24. 2011
    ..Alpha-2-globin chain has not been shown to be associated with AD. PPIaseA and cofilin-1 protein are correlated with cell apoptosis and signaling. The altered proteins identified may help to understand the pathogenesis of AD...
  2. pmc Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7
    Darja Kanduc
    CARSO Cancer Research Center, Valenzano, Regione Puglia, Italy
    J Virol 76:7040-8. 2002
    ..The in vitro data were confirmed by the occurrence of HPV16 E7 mRNA-cytokeratin 7 binding in squamous cervical cancer SiHa cells...
  3. ncbi Hb Luxembourg [alpha 24(B5) Tyr----His]: a new unstable variant
    P Groff
    Division d Hématologie, Laboratoire National de Santé, Luxembourg
    Hemoglobin 13:429-36. 1989
    ....
  4. ncbi Increased oxygen affinity with normal heterotropic effects in hemoglobin Loire [alpha 88(F9)Ala----Ser]
    F Baklouti
    CNRS UA 1171, Faculte de Medecine Grange Blanche, Lyon, France
    Eur J Biochem 177:307-12. 1988
    ..The functional properties of Hb Loire may be explained by a slight displacement of some key residues of the C-terminal region of the alpha chain destabilizing the T structure...
  5. ncbi Initiation codon mutation as a cause of alpha thalassemia
    M Pirastu
    J Biol Chem 259:12315-7. 1984
    ..The mutation is detectable in genomic DNA by restriction analysis with the enzyme NcoI. Of the seven Sardinian patients with nondeletion alpha thalassemia screened with this enzyme, six had the initiation codon lesion...
  6. ncbi Hb Aghia Sophia [alpha62(E11)Val-->0 (alpha1)], an "in-frame" deletion causing alpha-thalassemia
    J Traeger-Synodinos
    First Department of Pediatrics Aghia Sophia Children Hospital Athens University, Greece
    Hemoglobin 23:317-24. 1999
    ..The final result is an alpha-thalassemia phenotype rather than an unstable hemoglobin syndrome. This conclusion is supported by the apparent absence of an abnormal alpha chain in the peripheral blood of the patient...
  7. ncbi Hyperunstable hemoglobin Toyama [alpha 2 136(H19)Leu----Arg beta 2]: detection and identification by in vitro biosynthesis with radioactive amino acids
    Y Ohba
    Department of Clinical Laboratory Science, Yamaguchi University School of Medicine, Ube, Japan
    Hemoglobin 11:539-56. 1987
    ..The son, who also produced the abnormal alpha chain, was essentially free from hemolytic manifestation. His red cells were microcytic and showed an alpha/beta synthetic ratio of over 2...
  8. ncbi Identification of the molecular genetic defect of patients with methemoglobin M-Kankakee (M-Iwate), alpha87 (F8) His --> Tyr: evidence for an electrostatic model of alphaM hemoglobin assembly
    A Ameri
    Division of Pediatric Hematology Oncology and the Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Blood 94:1825-6. 1999
    ....
  9. ncbi Two new rat alpha-globin sequences as identified by the conserved region PCR
    V M Lam
    Department of Biochemistry, University of Hong Kong
    Hemoglobin 17:363-71. 1993
    ..Data of these amplified sequence constructs showed that two new rat alpha-globin specific sequences have been identified. Southern hybridization confirmed the presence of these sequences in the rat genome...
  10. pmc Neurons express hemoglobin alpha- and beta-chains in rat and human brains
    Franziska Richter
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 515:538-47. 2009
    ..Thus, hemoglobin chains are expressed in neurons and are regulated by treatments that affect mitochondria, opening up the possibility that they may play a novel role in neuronal function and response to injury...
  11. ncbi Hemopressin: a novel bioactive peptide derived from the alpha1-chain of hemoglobin
    Camila Squarzoni Dale
    Laboratorio de Fisiopatologia, Instituto Butantan, Sao Paulo, SP 05503 900, Brasil
    Mem Inst Oswaldo Cruz 100:105-6. 2005
    ..These findings suggest that this peptide may have important regulatory physiological actions in vivo...
  12. ncbi Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood
    Meiling Lu
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G3, Canada
    Chem Res Toxicol 17:1733-42. 2004
    ..The techniques and approaches described can be applied to the studies of arsenic interactions with other functional proteins...
  13. ncbi Glutamine synthetase, hemoglobin alpha-chain, and macrophage migration inhibitory factor binding to amyloid beta-protein: their identification in rat brain by a novel affinity chromatography and in Alzheimer's disease brain by immunoprecipitation
    R Oyama
    Department of Neuropathology, Faculty of Medicine, University of Tokyo, Japan
    Biochim Biophys Acta 1479:91-102. 2000
    ..Our results suggest that these binding proteins also associate with Abeta, leading to the clearance or the accumulation of Abeta and the neuronal cell damage in human brain...
  14. ncbi Molecular cloning and characterization of two sets of alpha-theta genes in the rat alpha-like globin gene cluster
    H Satoh
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo 113, Japan
    Gene 230:91-9. 1999
    ..These results indicate that the two gene regions investigated are not allelic variants, but may be generated by block duplication. This is the first report of the existence of rodent theta-globin genes...
  15. ncbi Purification and characterization of fatty acid-binding proteins from brown adipose tissue of the rat
    A K Dutta-Roy
    Division of Biochemical Sciences, Rowett Research Institute, Aberdeen, UK
    Biochim Biophys Acta 1169:73-9. 1993
    ..Further studies are required to elucidate the precise function of the two different isoforms of FABP in brown adipose tissue...
  16. pmc Rat haemoglobin heterogeneity. Two structurally distinct alpha chains and functional behaviour of selected components
    L M Garrick
    Biochem J 149:245-58. 1975
    ..Both the haemolysate and the two haemoglobins showed an alkaline Bohr effect larger than that of human haemoglobin A...
  17. ncbi Structural, functional and conformational properties of rat hemoglobins
    M E John
    Eur J Biochem 124:305-10. 1982
    ..This is in contrast to the polymerization of human deoxyhemoglobin S, where gel formation occurs only in the T state...
  18. ncbi Characterization of two rat globin cDNA clones
    R Crkvenjakov
    Hemoglobin 8:597-611. 1984
    ..These cloned cDNAs will be useful probes of structure and function of rat globin genes. The deduced amino acid sequences extend the information about the variability of rat globin chains...
  19. ncbi Three cysteine residues in the alpha chain of rat haemoglobin (albino Rattus norvegicus): 13 (A 11), 104 (G 11) and 111 (G 18)
    C G Chua
    Biochim Biophys Acta 365:328-34. 1974
  20. ncbi Molecular cloning and sequence analysis of two rat major globin cDNAs
    H Satoh
    Biochem Biophys Res Commun 146:618-24. 1987
    ..The cause of diversity of rat globins was discussed in terms of the nucleotide sequences of cDNAs and known amino acid sequences of globins...
  21. pmc The amino acid sequence of the alpha chain of the major haemoglobin of the rat (Rattus norvegicus)
    C G Chua
    Biochem J 149:259-69. 1975
    ..K., from which copies can be obtained on the terms given in Biochem. J. (1975) 145, 5...