Genomes and Genes
Gene Symbol: Gucy1a3
Description: guanylate cyclase 1 soluble subunit alpha 3
Alias: Gucy1a1, SGC, guanylate cyclase soluble subunit alpha-3, GCS-alpha-1, GCS-alpha-3, Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase), guanylate cyclase 1, soluble, alpha 3, soluble guanylate cyclase large subunit
- Hypoxia decreases expression of soluble guanylate cyclase in cultured rat pulmonary artery smooth muscle cellsPaul M Hassoun
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Respir Cell Mol Biol 30:908-13. 2004..NO acts, in part, by stimulating soluble guanylate cyclase (sGC) to synthesize the intracellular second messenger cyclic GMP...
- Genetic mapping of soluble guanylyl cyclase genes: implications for linkage to blood pressure in the Dahl ratM Azam
Department of Internal Medicine, Columbia University, New York, NY 10032, USA
Hypertension 32:149-54. 1998..0), which has been shown to cosegregate with blood pressure. We conclude that soluble guanylyl cyclase subunit loci, ie, alpha1, beta1, and beta2, are good candidates for genes controlling salt-sensitive hypertension in the Dahl rat...
- Alteration of basilar artery rho-kinase and soluble guanylyl cyclase protein expression in a rat model of cerebral vasospasm following subarachnoid hemorrhageChih Jen Wang
Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan Department of Neurosurgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Biomed Res Int 2014:531508. 2014..In the present study, we assessed the effect of CGS 26303 on neurological deficits in SAH rats. The involvement of vasoactive pathways downstream of ET-1 signaling in SAH was also investigated...
- Nucleotidyl cyclase activity of soluble guanylyl cyclase α1β1Kerstin Y Beste
Institute of Pharmacology, Hannover Medical School, Hannover, Germany
Biochemistry 51:194-204. 2012Soluble guanylyl cyclase (sGC) regulates several important physiological processes by converting GTP into the second-messenger cGMP. sGC has several structural and functional properties in common with adenylyl cyclases (ACs)...
- Glucagon-like peptide-2 (GLP-2) modulates the cGMP signalling pathway by regulating the expression of the soluble guanylyl cyclase receptor subunits in cultured rat astrocytesEsther Velázquez
Department of Biochemistry and Molecular Biology, Complutense University Plaza S Ramón y Cajal s n, 28040 Madrid, Spain
Mol Neurobiol 46:242-50. 2012..whether variations in cGMP production might be related with changes in some component of soluble guanylyl cyclase (sGC), the expression of the α1, α2, and β1 subunits were determined by Western blot analysis...
- Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxideNathaniel B Fernhoff
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
J Biol Chem 287:43053-62. 2012..Soluble guanylate cyclase (sGC), the mammalian NO sensor, transduces an NO signal into the classical second messenger cyclic GMP (cGMP)...
- Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidenceMohammed Ibrahim
Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
Biochemistry 49:4864-71. 2010Modulation of soluble guanylate cyclase (sGC) activity by nitric oxide (NO) involves two distinct steps...
- Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cellsJose M Moran
Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Departamento de Bioquimica y Biologia Molecular y Genetica, EU Enfermería y TO, Universidad de Extremadura, Avda Universidad s n 10071 Cáceres, Spain
Nitric Oxide 23:51-9. 2010..expression, we examined changes in GCH1, ARG1, ARG2, NOS1, NOS2, NOS3, NOSTRIN, NOSIP, NOS1AP, RASD1, DYNLL1, GUCY1A3, DDAH1, DDAH2 and CYGB genes whose expression is controlled by or involved in signaling by the second messenger ..
- Characterization of the human alpha1 beta1 soluble guanylyl cyclase promoter: key role for NF-kappaB(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptorMartin L Marro
Department of Pharmacology, University College London, Medical Sciences Building, London, UK
J Biol Chem 283:20027-36. 2008Soluble guanylyl cyclase (sGC) is the principal receptor for NO and plays a ubiquitous role in regulating cellular function...
- Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopyMohammed Ibrahim
Department of Chemistry, University of Washington, Seattle, Washington 98195 1700, USA
Biochemistry 49:3815-23. 2010Soluble guanylate cyclase (sGC) is weakly activated by carbon monoxide (CO) but is significantly activated by the binding of YC-1 to the sGC-CO complex...
- Transforming growth factor-beta modulates the expression of nitric oxide signaling enzymes in the injured developing lung and in vascular smooth muscle cellsPatricia R Bachiller
Cardiovascular Research Center, Massachusetts General Hospital East, 149 13th St, Charlestown, MA 02129, USA
Am J Physiol Lung Cell Mol Physiol 298:L324-34. 2010..Expression of soluble guanylate cyclase (sGC) and cGMP-dependent protein kinase I (PKGI), both critical mediators of nitric oxide (NO) signaling, is diminished ..
- The expression of soluble guanylate cyclase in the vasculature of rat skeletal muscleTamotsu Fukutani
Department of Physical Therapy, Nagano Rehabilitation College, Nagano, Japan
Arch Histol Cytol 72:117-26. 2009..NO primarily activates soluble guanylate cyclase (sGC) and mediates subsequent intracellular signaling in target cells...
- Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradationL S Hoffmann
Pharma Research Centre, Bayer HealthCare, Aprather Weg 18a, Wuppertal, Germany
Br J Pharmacol 157:781-95. 2009..by nitric oxide (NO) is impaired because of the oxidation and subsequent loss of the soluble guanylyl cyclase (sGC) haem...
- Nitric oxide sensitive-guanylyl cyclase subunit expression changes during estrous cycle in anterior pituitary glandsJimena P Cabilla
Departamento de Quimica Biologica, IQUIFIB, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, Buenos Aires, Argentina
Am J Physiol Endocrinol Metab 296:E731-7. 2009..Previously, we reported that in vivo E2 acute treatment had opposite effects on soluble guanylyl cyclase (sGC) subunits, increasing alpha1- and decreasing beta1-subunit protein and mRNA expression and decreasing sGC activity ..
- Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostateRussell L Legg
Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA
Reprod Biol Endocrinol 6:57. 2008..These components each affect androgen-regulated gene expression. The objective of this work was to determine the combined effects of selenium and isoflavones on androgen-regulated gene expression in rat prostate...
- Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activityZongmin Zhou
Critical Care Department, Evangelismos Hospital, University of Athens School of Medicine, Greece
Arterioscler Thromb Vasc Biol 28:1803-10. 2008Binding of nitric oxide (NO) to soluble guanylyl cyclase (sGC) leads to increased cGMP synthesis that activates cGMP-dependent protein kinase (PKG). Herein, we tested whether sGC activity is regulated by PKG.
- Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colonIngeborg Dhaese
Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
Eur J Pharmacol 589:251-9. 2008..The role of the soluble guanylate cyclase (sGC) isoforms alpha(1)beta(1) and alpha(2)beta(1), and of the small conductance Ca(2+)-dependent K(+) channels (SK(Ca) ..
- Expression and function of soluble guanylate cyclase in pulmonary arterial hypertensionR T Schermuly
University of Giessen Lung Centre, Giessen, Germany
Eur Respir J 32:881-91. 2008Alterations of the nitric oxide receptor, soluble guanylate cyclase (sGC) may contribute to the pathophysiology of pulmonary arterial hypertension (PAH)...
- Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lungM Nakane
Tokyo Metropolitan Institute for Neurosciences, Japan
J Biol Chem 265:16841-5. 1990..Presumably both catalytic subunits must be present and interactive to permit synthesis of cyclic GMP and nitrovasodilator activation...
- Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitisKoen Van Crombruggen
Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185, 900 Ghent, Belgium
Eur J Pharmacol 579:337-49. 2008..The involvement of soluble guanylate cyclase (sGC)--the downstream effector of NO--in the negative effect of NO in inflammatory models has been proposed but this has ..
- Modulation of voltage-gated Ca2+ current in vestibular hair cells by nitric oxideAngélica Almanza
Instituto de Fisiologia, Universidad Autonoma de Puebla, Puebla 72000, Mexico
J Neurophysiol 97:1188-95. 2007..The selective inhibitor of the soluble form of the enzyme guanylate cyclase (sGC), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), also decreased the SNP-induced inhibition of the Ca(2+) ..
- Molecular cloning and characterization of alpha1-soluble guanylyl cyclase gene promoter in rat pituitary cellsYonghua Jiang
Section on Cellular Signaling, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4510, USA
J Mol Endocrinol 37:503-15. 2006..These results indicate that the composite CCAAT/Sp1 cis-element contributes to the expression of alpha1-sGC subunit in resting pituitary cells.
- Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructsJonathan A Winger
Department of Medicinal Chemistry, The University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 282:897-907. 2007Regulation of soluble guanylate cyclase (sGC), the primary NO receptor, is linked to NO binding to the prosthetic heme group...
- Effects of hsp90 binding inhibitors on sGC-mediated vascular relaxationGunay Yetik-Anacak
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
Am J Physiol Heart Circ Physiol 291:H260-8. 2006Vascular soluble guanylate cyclase (sGC) exists in multimeric complexes with endothelial nitric oxide (NO) synthase (eNOS) and heat shock protein 90 (hsp90)...
- Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTPStephen P L Cary
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 102:13064-9. 2005..NO) affects many physiological systems by activating cGMP signaling cascades through soluble guanylate cyclase (sGC). In the accepted model, NO binds to the sGC heme, activating the enzyme...
- Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating bindingAndreas Papapetropoulos
G P Livanos and M Simou Laboratories, Evangelismos Hospital, Department of Critical Care and Pulmonary Services, University of Athens, Greece
Mol Pharmacol 68:1133-41. 2005..Soluble guanylyl cyclase (sGC), an NO receptor, was recently reported to be an hsp90-interacting partner...
- Cell-specific expression and regulation of soluble guanylyl cyclase alpha 1 and beta 1 subunits in the rat ovaryFangxiong Shi
Department of Biological Sciences, California State University Los Angeles, Los Angeles, California 90032, USA
Biol Reprod 70:1552-61. 2004Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and carbon monoxide, resulting in cGMP production. Recent studies indicate that NO and cGMP influence ovarian functions...
- Post-transcriptional regulation of soluble guanylyl cyclase expression in rat aortaStephan Kloss
Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, Frankfurt Main D60590, Germany
J Biol Chem 278:2377-83. 2003..Activation of guanylyl cyclase decreases HuR expression, inducing a rapid degradation of guanylyl cyclase alpha(1) mRNA and lowering alpha(1) subunit expression as a negative feedback response...
- Regional distribution of protein and activity of the nitric oxide receptor, soluble guanylyl cyclase, in rat brain suggests multiple mechanisms of regulationPavel I Nedvetsky
Rudolf Buchheim Institute for Pharmacology, Justus Liebig University, Frankfurter Str 107, D 35392, Giessen, Germany
Brain Res 950:148-54. 2002..Its effects are often mediated by activation of its cytosolic receptor, the hemoprotein soluble guanylyl cyclase (sGC)...
- Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial cellsMaria Antonia Baltrons
Instituto de Biotecnología y Biomedicina V Villar Palasi, Departamento de Bioquímica Biologia Molecular, Universidad Autonoma de Barcelona, 08193, Bellaterra, Spain
Neurobiol Dis 10:139-49. 2002..accumulate cyclic GMP (cGMP) in response to NO as a result of a decreased expression of soluble guanylyl cyclase (sGC) at the protein and mRNA levels...
- Activation and up-regulation of spinal cord nitric oxide receptor, soluble guanylate cyclase, after formalin injection into the rat hind pawY X Tao
Department of Anesthesiology and Critical Care Medicine, Blalock 1415, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 4965, USA
Neuroscience 112:439-46. 2002....
- The alpha 1 subunit of soluble guanylyl cyclase is expressed prenatally in the rat brainR Smigrodzki
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway 08854, USA
Brain Res Dev Brain Res 97:226-34. 1996..expression of alpha 1sGC, in conjunction with the known absence of its heterodimeric partner, the beta subunit of sGC, from the developing rodent brain during fetal ages raises potentially novel functional roles of the alpha 1 ..