Gucy1a3

Summary

Gene Symbol: Gucy1a3
Description: guanylate cyclase 1 soluble subunit alpha 3
Alias: Gucy1a1, SGC, guanylate cyclase soluble subunit alpha-3, GCS-alpha-1, GCS-alpha-3, Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase), guanylate cyclase 1, soluble, alpha 3, soluble guanylate cyclase large subunit
Species: rat

Top Publications

  1. ncbi Hypoxia decreases expression of soluble guanylate cyclase in cultured rat pulmonary artery smooth muscle cells
    Paul M Hassoun
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Cell Mol Biol 30:908-13. 2004
  2. ncbi Genetic mapping of soluble guanylyl cyclase genes: implications for linkage to blood pressure in the Dahl rat
    M Azam
    Department of Internal Medicine, Columbia University, New York, NY 10032, USA
    Hypertension 32:149-54. 1998
  3. pmc Alteration of basilar artery rho-kinase and soluble guanylyl cyclase protein expression in a rat model of cerebral vasospasm following subarachnoid hemorrhage
    Chih Jen Wang
    Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan Department of Neurosurgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Biomed Res Int 2014:531508. 2014
  4. doi Nucleotidyl cyclase activity of soluble guanylyl cyclase α1β1
    Kerstin Y Beste
    Institute of Pharmacology, Hannover Medical School, Hannover, Germany
    Biochemistry 51:194-204. 2012
  5. doi Glucagon-like peptide-2 (GLP-2) modulates the cGMP signalling pathway by regulating the expression of the soluble guanylyl cyclase receptor subunits in cultured rat astrocytes
    Esther Velázquez
    Department of Biochemistry and Molecular Biology, Complutense University Plaza S Ramón y Cajal s n, 28040 Madrid, Spain
    Mol Neurobiol 46:242-50. 2012
  6. pmc Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide
    Nathaniel B Fernhoff
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    J Biol Chem 287:43053-62. 2012
  7. pmc Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence
    Mohammed Ibrahim
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    Biochemistry 49:4864-71. 2010
  8. doi Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells
    Jose M Moran
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Departamento de Bioquimica y Biologia Molecular y Genetica, EU Enfermería y TO, Universidad de Extremadura, Avda Universidad s n 10071 Cáceres, Spain
    Nitric Oxide 23:51-9. 2010
  9. pmc Characterization of the human alpha1 beta1 soluble guanylyl cyclase promoter: key role for NF-kappaB(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor
    Martin L Marro
    Department of Pharmacology, University College London, Medical Sciences Building, London, UK
    J Biol Chem 283:20027-36. 2008
  10. pmc Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy
    Mohammed Ibrahim
    Department of Chemistry, University of Washington, Seattle, Washington 98195 1700, USA
    Biochemistry 49:3815-23. 2010

Scientific Experts

  • A Papapetropoulos
  • Paul M Hassoun
  • Pavel I Nedvetsky
  • Ralph Theo Schermuly
  • Jose M Moran
  • Russell L Legg
  • Michael A Marletta
  • Mohammed Ibrahim
  • Emily R Derbyshire
  • Jonathan A Winger
  • Chih Jen Wang
  • Kerstin Y Beste
  • Nathaniel B Fernhoff
  • Esther Velázquez
  • Patricia R Bachiller
  • Thomas G Spiro
  • L S Hoffmann
  • Jimena P Cabilla
  • Tamotsu Fukutani
  • Koen Van Crombruggen
  • Ingeborg Dhaese
  • Zongmin Zhou
  • Romain A Lefebvre
  • Martin L Marro
  • Angélica Almanza
  • Gunay Yetik-Anacak
  • Yonghua Jiang
  • Stephen P L Cary
  • Fangxiong Shi
  • Stephan Kloss
  • Pei Yu Lee
  • Bin Nan Wu
  • Maria Antonia Baltrons
  • Neal F Kassell
  • Y X Tao
  • Chia Li Chung
  • Joon Khim Loh
  • Shu Chuan Wu
  • Aij Lie Kwan
  • Hung Pei Tsai
  • Enrique Blazquez
  • Johannes Peter Stasch
  • Juan Miguel Ruiz-Albusac
  • Volkhard Kaever
  • Eric S Underbakke
  • Heike Burhenne
  • Roland Seifert
  • Alexandra V Soldatova
  • Jesse D Roberts
  • Hidehiko Nakanishi
  • J P Stasch
  • Beatriz H Duvilanski
  • P M Schmidt
  • H H H W Schmidt
  • Y Keim
  • Silvana I Nudler
  • Yoshiaki Nojyo
  • Satoshi Iino
  • S Schaefer
  • Eliana A Miler
  • Fernanda A Quinteros
  • Sonia A Ronchetti
  • Jean Pierre Timmermans
  • Adrian J Hobbs
  • Pieter Demetter
  • Claude Cuvelier
  • Annie Beuve
  • Nazish Sayed
  • Emmanuel Buys
  • Harald H H W Schmidt
  • Concepcion Peiro
  • Anastasia Pyriochou
  • Reshma S Baliga
  • Charis Roussos
  • Gwen Vanneste
  • David Fulton
  • Peter Brouckaert
  • Catherine M Panayiotou
  • Sabine Meurer
  • Patrick Sips
  • Luc Van Nassauw
  • Francisco Navarrete
  • Rosario Vega
  • Enrique Soto
  • Stanko S Stojilkovic
  • Richard C Venema
  • Tian Xia
  • M Azam
  • John D Catravas
  • Christiana Dimitropoulou

Detail Information

Publications32

  1. ncbi Hypoxia decreases expression of soluble guanylate cyclase in cultured rat pulmonary artery smooth muscle cells
    Paul M Hassoun
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Cell Mol Biol 30:908-13. 2004
    ..NO acts, in part, by stimulating soluble guanylate cyclase (sGC) to synthesize the intracellular second messenger cyclic GMP...
  2. ncbi Genetic mapping of soluble guanylyl cyclase genes: implications for linkage to blood pressure in the Dahl rat
    M Azam
    Department of Internal Medicine, Columbia University, New York, NY 10032, USA
    Hypertension 32:149-54. 1998
    ..0), which has been shown to cosegregate with blood pressure. We conclude that soluble guanylyl cyclase subunit loci, ie, alpha1, beta1, and beta2, are good candidates for genes controlling salt-sensitive hypertension in the Dahl rat...
  3. pmc Alteration of basilar artery rho-kinase and soluble guanylyl cyclase protein expression in a rat model of cerebral vasospasm following subarachnoid hemorrhage
    Chih Jen Wang
    Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan Department of Neurosurgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Biomed Res Int 2014:531508. 2014
    ..In the present study, we assessed the effect of CGS 26303 on neurological deficits in SAH rats. The involvement of vasoactive pathways downstream of ET-1 signaling in SAH was also investigated...
  4. doi Nucleotidyl cyclase activity of soluble guanylyl cyclase α1β1
    Kerstin Y Beste
    Institute of Pharmacology, Hannover Medical School, Hannover, Germany
    Biochemistry 51:194-204. 2012
    Soluble guanylyl cyclase (sGC) regulates several important physiological processes by converting GTP into the second-messenger cGMP. sGC has several structural and functional properties in common with adenylyl cyclases (ACs)...
  5. doi Glucagon-like peptide-2 (GLP-2) modulates the cGMP signalling pathway by regulating the expression of the soluble guanylyl cyclase receptor subunits in cultured rat astrocytes
    Esther Velázquez
    Department of Biochemistry and Molecular Biology, Complutense University Plaza S Ramón y Cajal s n, 28040 Madrid, Spain
    Mol Neurobiol 46:242-50. 2012
    ..whether variations in cGMP production might be related with changes in some component of soluble guanylyl cyclase (sGC), the expression of the α1, α2, and β1 subunits were determined by Western blot analysis...
  6. pmc Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide
    Nathaniel B Fernhoff
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    J Biol Chem 287:43053-62. 2012
    ..Soluble guanylate cyclase (sGC), the mammalian NO sensor, transduces an NO signal into the classical second messenger cyclic GMP (cGMP)...
  7. pmc Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence
    Mohammed Ibrahim
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    Biochemistry 49:4864-71. 2010
    Modulation of soluble guanylate cyclase (sGC) activity by nitric oxide (NO) involves two distinct steps...
  8. doi Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells
    Jose M Moran
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Departamento de Bioquimica y Biologia Molecular y Genetica, EU Enfermería y TO, Universidad de Extremadura, Avda Universidad s n 10071 Cáceres, Spain
    Nitric Oxide 23:51-9. 2010
    ..expression, we examined changes in GCH1, ARG1, ARG2, NOS1, NOS2, NOS3, NOSTRIN, NOSIP, NOS1AP, RASD1, DYNLL1, GUCY1A3, DDAH1, DDAH2 and CYGB genes whose expression is controlled by or involved in signaling by the second messenger ..
  9. pmc Characterization of the human alpha1 beta1 soluble guanylyl cyclase promoter: key role for NF-kappaB(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor
    Martin L Marro
    Department of Pharmacology, University College London, Medical Sciences Building, London, UK
    J Biol Chem 283:20027-36. 2008
    Soluble guanylyl cyclase (sGC) is the principal receptor for NO and plays a ubiquitous role in regulating cellular function...
  10. pmc Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy
    Mohammed Ibrahim
    Department of Chemistry, University of Washington, Seattle, Washington 98195 1700, USA
    Biochemistry 49:3815-23. 2010
    Soluble guanylate cyclase (sGC) is weakly activated by carbon monoxide (CO) but is significantly activated by the binding of YC-1 to the sGC-CO complex...
  11. pmc Transforming growth factor-beta modulates the expression of nitric oxide signaling enzymes in the injured developing lung and in vascular smooth muscle cells
    Patricia R Bachiller
    Cardiovascular Research Center, Massachusetts General Hospital East, 149 13th St, Charlestown, MA 02129, USA
    Am J Physiol Lung Cell Mol Physiol 298:L324-34. 2010
    ..Expression of soluble guanylate cyclase (sGC) and cGMP-dependent protein kinase I (PKGI), both critical mediators of nitric oxide (NO) signaling, is diminished ..
  12. ncbi The expression of soluble guanylate cyclase in the vasculature of rat skeletal muscle
    Tamotsu Fukutani
    Department of Physical Therapy, Nagano Rehabilitation College, Nagano, Japan
    Arch Histol Cytol 72:117-26. 2009
    ..NO primarily activates soluble guanylate cyclase (sGC) and mediates subsequent intracellular signaling in target cells...
  13. pmc Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation
    L S Hoffmann
    Pharma Research Centre, Bayer HealthCare, Aprather Weg 18a, Wuppertal, Germany
    Br J Pharmacol 157:781-95. 2009
    ..by nitric oxide (NO) is impaired because of the oxidation and subsequent loss of the soluble guanylyl cyclase (sGC) haem...
  14. doi Nitric oxide sensitive-guanylyl cyclase subunit expression changes during estrous cycle in anterior pituitary glands
    Jimena P Cabilla
    Departamento de Quimica Biologica, IQUIFIB, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, Buenos Aires, Argentina
    Am J Physiol Endocrinol Metab 296:E731-7. 2009
    ..Previously, we reported that in vivo E2 acute treatment had opposite effects on soluble guanylyl cyclase (sGC) subunits, increasing alpha1- and decreasing beta1-subunit protein and mRNA expression and decreasing sGC activity ..
  15. pmc Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate
    Russell L Legg
    Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA
    Reprod Biol Endocrinol 6:57. 2008
    ..These components each affect androgen-regulated gene expression. The objective of this work was to determine the combined effects of selenium and isoflavones on androgen-regulated gene expression in rat prostate...
  16. pmc Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity
    Zongmin Zhou
    Critical Care Department, Evangelismos Hospital, University of Athens School of Medicine, Greece
    Arterioscler Thromb Vasc Biol 28:1803-10. 2008
    Binding of nitric oxide (NO) to soluble guanylyl cyclase (sGC) leads to increased cGMP synthesis that activates cGMP-dependent protein kinase (PKG). Herein, we tested whether sGC activity is regulated by PKG.
  17. doi Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon
    Ingeborg Dhaese
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    Eur J Pharmacol 589:251-9. 2008
    ..The role of the soluble guanylate cyclase (sGC) isoforms alpha(1)beta(1) and alpha(2)beta(1), and of the small conductance Ca(2+)-dependent K(+) channels (SK(Ca) ..
  18. doi Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension
    R T Schermuly
    University of Giessen Lung Centre, Giessen, Germany
    Eur Respir J 32:881-91. 2008
    Alterations of the nitric oxide receptor, soluble guanylate cyclase (sGC) may contribute to the pathophysiology of pulmonary arterial hypertension (PAH)...
  19. ncbi Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung
    M Nakane
    Tokyo Metropolitan Institute for Neurosciences, Japan
    J Biol Chem 265:16841-5. 1990
    ..Presumably both catalytic subunits must be present and interactive to permit synthesis of cyclic GMP and nitrovasodilator activation...
  20. ncbi Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitis
    Koen Van Crombruggen
    Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185, 900 Ghent, Belgium
    Eur J Pharmacol 579:337-49. 2008
    ..The involvement of soluble guanylate cyclase (sGC)--the downstream effector of NO--in the negative effect of NO in inflammatory models has been proposed but this has ..
  21. ncbi Modulation of voltage-gated Ca2+ current in vestibular hair cells by nitric oxide
    Angélica Almanza
    Instituto de Fisiologia, Universidad Autonoma de Puebla, Puebla 72000, Mexico
    J Neurophysiol 97:1188-95. 2007
    ..The selective inhibitor of the soluble form of the enzyme guanylate cyclase (sGC), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), also decreased the SNP-induced inhibition of the Ca(2+) ..
  22. ncbi Molecular cloning and characterization of alpha1-soluble guanylyl cyclase gene promoter in rat pituitary cells
    Yonghua Jiang
    Section on Cellular Signaling, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4510, USA
    J Mol Endocrinol 37:503-15. 2006
    ..These results indicate that the composite CCAAT/Sp1 cis-element contributes to the expression of alpha1-sGC subunit in resting pituitary cells.
  23. ncbi Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs
    Jonathan A Winger
    Department of Medicinal Chemistry, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:897-907. 2007
    Regulation of soluble guanylate cyclase (sGC), the primary NO receptor, is linked to NO binding to the prosthetic heme group...
  24. ncbi Effects of hsp90 binding inhibitors on sGC-mediated vascular relaxation
    Gunay Yetik-Anacak
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Am J Physiol Heart Circ Physiol 291:H260-8. 2006
    Vascular soluble guanylate cyclase (sGC) exists in multimeric complexes with endothelial nitric oxide (NO) synthase (eNOS) and heat shock protein 90 (hsp90)...
  25. pmc Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP
    Stephen P L Cary
    Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 102:13064-9. 2005
    ..NO) affects many physiological systems by activating cGMP signaling cascades through soluble guanylate cyclase (sGC). In the accepted model, NO binds to the sGC heme, activating the enzyme...
  26. ncbi Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding
    Andreas Papapetropoulos
    G P Livanos and M Simou Laboratories, Evangelismos Hospital, Department of Critical Care and Pulmonary Services, University of Athens, Greece
    Mol Pharmacol 68:1133-41. 2005
    ..Soluble guanylyl cyclase (sGC), an NO receptor, was recently reported to be an hsp90-interacting partner...
  27. ncbi Cell-specific expression and regulation of soluble guanylyl cyclase alpha 1 and beta 1 subunits in the rat ovary
    Fangxiong Shi
    Department of Biological Sciences, California State University Los Angeles, Los Angeles, California 90032, USA
    Biol Reprod 70:1552-61. 2004
    Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and carbon monoxide, resulting in cGMP production. Recent studies indicate that NO and cGMP influence ovarian functions...
  28. ncbi Post-transcriptional regulation of soluble guanylyl cyclase expression in rat aorta
    Stephan Kloss
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, Frankfurt Main D60590, Germany
    J Biol Chem 278:2377-83. 2003
    ..Activation of guanylyl cyclase decreases HuR expression, inducing a rapid degradation of guanylyl cyclase alpha(1) mRNA and lowering alpha(1) subunit expression as a negative feedback response...
  29. ncbi Regional distribution of protein and activity of the nitric oxide receptor, soluble guanylyl cyclase, in rat brain suggests multiple mechanisms of regulation
    Pavel I Nedvetsky
    Rudolf Buchheim Institute for Pharmacology, Justus Liebig University, Frankfurter Str 107, D 35392, Giessen, Germany
    Brain Res 950:148-54. 2002
    ..Its effects are often mediated by activation of its cytosolic receptor, the hemoprotein soluble guanylyl cyclase (sGC)...
  30. ncbi Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial cells
    Maria Antonia Baltrons
    Instituto de Biotecnología y Biomedicina V Villar Palasi, Departamento de Bioquímica Biologia Molecular, Universidad Autonoma de Barcelona, 08193, Bellaterra, Spain
    Neurobiol Dis 10:139-49. 2002
    ..accumulate cyclic GMP (cGMP) in response to NO as a result of a decreased expression of soluble guanylyl cyclase (sGC) at the protein and mRNA levels...
  31. ncbi Activation and up-regulation of spinal cord nitric oxide receptor, soluble guanylate cyclase, after formalin injection into the rat hind paw
    Y X Tao
    Department of Anesthesiology and Critical Care Medicine, Blalock 1415, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 4965, USA
    Neuroscience 112:439-46. 2002
    ....
  32. ncbi The alpha 1 subunit of soluble guanylyl cyclase is expressed prenatally in the rat brain
    R Smigrodzki
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway 08854, USA
    Brain Res Dev Brain Res 97:226-34. 1996
    ..expression of alpha 1sGC, in conjunction with the known absence of its heterodimeric partner, the beta subunit of sGC, from the developing rodent brain during fetal ages raises potentially novel functional roles of the alpha 1 ..