Gstt1

Summary

Gene Symbol: Gstt1
Description: glutathione S-transferase theta 1
Alias: GSTYRS, glutathione S-transferase theta-1, GST 5-5, GST class-theta-1, Glutathione S-transferase 1 (theta), glutathione S-transferase 5
Species: rat

Top Publications

  1. ncbi Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease
    Gianfranco Spalletta
    Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy
    Am J Geriatr Psychiatry 15:879-87. 2007
  2. doi Polymorphism of glutathione S-transferase M1 and T1 gene loci in COPD
    S Mehrotra
    Department of Cardiology, Nehru Hospital, PGI, Chandigarh, India
    Int J Immunogenet 37:263-7. 2010
  3. doi GSTM1 and GSTT1 deletion genotypes in various spontaneous optic neuropathies in Arabs
    K K Abu-Amero
    Department of Ophthalmology, College of Medicine, King Saud University, PO Box 245, Riyadh 11411, Saudi Arabia
    Br J Ophthalmol 93:1101-4. 2009
  4. ncbi Glutathione S transferase theta 1 gene (GSTT1) null genotype is associated with an increased risk for acquired aplastic anemia in children
    Uta Dirksen
    Department of Pediatric Hematology and Oncology, Childrens Hospital Heinrich Heine University Medical School, Moorenstr 5, 40225 Duesseldorf, Germany
    Pediatr Res 55:466-71. 2004
  5. ncbi Is GST gene polymorphism a risk factor in developing exfoliation syndrome?
    Ayca Yilmaz
    Ophthalmology Department, Mersin University Faculty of Medicine, Mersin, Turkey
    Curr Eye Res 30:575-81. 2005
  6. ncbi GST genotype may modify clinical phenotype in patients with Fanconi anaemia
    Stella M Davies
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45329, USA
    Br J Haematol 131:118-22. 2005
  7. ncbi Determination of glutathione S-transferase mu and theta polymorphisms in neurological disease
    M C Stroombergen
    Department of Biochemistry, University of Birmingham, UK
    Hum Exp Toxicol 18:141-5. 1999
  8. ncbi Glutathione S-transferase M1, T1, and P1 gene polymorphism in exudative age-related macular degeneration: a preliminary report
    O Oz
    Department of Ophthalmology, Faculty of Medicine, Mersin University, Mersin, Turkey
    Eur J Ophthalmol 16:105-10. 2006
  9. doi Glutathione S-transferase gene deletions and their effect on iron status in HbE/beta thalassemia patients
    Vineeta Sharma
    Department of Hematology, I R C H Building first floor, All India Institute of Medical Sciences AIIMS, Ansari Nagar, New Delhi 110 029, India
    Ann Hematol 89:411-4. 2010
  10. ncbi Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 48:5558-66. 2007

Research Grants

Scientific Experts

Detail Information

Publications83

  1. ncbi Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease
    Gianfranco Spalletta
    Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy
    Am J Geriatr Psychiatry 15:879-87. 2007
    ..Therefore, the authors studied the effect of glutathione S-transferase (GST) P1-M1-T1 gene polymorphisms and their interactions with the apolipoprotein E (ApoE) epsilon4 allelic variant on the three-year longitudinal course of AD...
  2. doi Polymorphism of glutathione S-transferase M1 and T1 gene loci in COPD
    S Mehrotra
    Department of Cardiology, Nehru Hospital, PGI, Chandigarh, India
    Int J Immunogenet 37:263-7. 2010
    ..Present study was a case-control study of COPD patients and healthy controls. Genetic polymorphisms of GSTM1 and GSTT1 genes in 50 COPD patients and 50 healthy controls were investigated using multiplex polymerase chain reaction-..
  3. doi GSTM1 and GSTT1 deletion genotypes in various spontaneous optic neuropathies in Arabs
    K K Abu-Amero
    Department of Ophthalmology, College of Medicine, King Saud University, PO Box 245, Riyadh 11411, Saudi Arabia
    Br J Ophthalmol 93:1101-4. 2009
    To investigate whether the prevalence GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0 and T0M0) are increased in certain spontaneous optic neuropathies.
  4. ncbi Glutathione S transferase theta 1 gene (GSTT1) null genotype is associated with an increased risk for acquired aplastic anemia in children
    Uta Dirksen
    Department of Pediatric Hematology and Oncology, Childrens Hospital Heinrich Heine University Medical School, Moorenstr 5, 40225 Duesseldorf, Germany
    Pediatr Res 55:466-71. 2004
    ..The GSTT1 null genotype (absence of both alleles) was associated with a significantly increased risk for acquired aplastic ..
  5. ncbi Is GST gene polymorphism a risk factor in developing exfoliation syndrome?
    Ayca Yilmaz
    Ophthalmology Department, Mersin University Faculty of Medicine, Mersin, Turkey
    Curr Eye Res 30:575-81. 2005
    To evaluate the distribution of GSTM1, GSTP1, and GSTT1 gene polymorphisms in exfoliation syndrome (XFS) and the possible associations between the presence of exfoliation syndrome and glutathione S-transferase (GST) gene polymorphisms.
  6. ncbi GST genotype may modify clinical phenotype in patients with Fanconi anaemia
    Stella M Davies
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45329, USA
    Br J Haematol 131:118-22. 2005
    ..the Fanconi anaemia (FA) phenotype, we examined the role of polymorphism in three glutathione s-transferase genes (GSTT1, GSTM1 and GSTP1) in 356 FA patients enrolled in the International Fanconi Anaemia Registry (IFAR)...
  7. ncbi Determination of glutathione S-transferase mu and theta polymorphisms in neurological disease
    M C Stroombergen
    Department of Biochemistry, University of Birmingham, UK
    Hum Exp Toxicol 18:141-5. 1999
    1. Correlations between deletions in two glutathione S-transferase (GST) genes, GSTM1 and GSTT1 and susceptibility to Alzheimer's disease (AD), motor neuron disease (MND) and Parkinson's disease (PD) have been investigated by PCR, using ..
  8. ncbi Glutathione S-transferase M1, T1, and P1 gene polymorphism in exudative age-related macular degeneration: a preliminary report
    O Oz
    Department of Ophthalmology, Faculty of Medicine, Mersin University, Mersin, Turkey
    Eur J Ophthalmol 16:105-10. 2006
    ..To elucidate whether the gene polymorphisms of glutathione S-transferase (GST) M1, T1, and P1 are associated with the development of exudative age-related macular degeneration...
  9. doi Glutathione S-transferase gene deletions and their effect on iron status in HbE/beta thalassemia patients
    Vineeta Sharma
    Department of Hematology, I R C H Building first floor, All India Institute of Medical Sciences AIIMS, Ansari Nagar, New Delhi 110 029, India
    Ann Hematol 89:411-4. 2010
    ..Glutathione S-transferase genes (GSTT1 and GSTM1) are well known detoxification agents, and any mutation in the gene is known to cause oxidative damage...
  10. ncbi Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 48:5558-66. 2007
    ..The expression of stress-related genes in eyes from patients with and without PEX syndrome/glaucoma was investigated to determine whether PEX syndrome is associated with an altered cellular stress response...
  11. ncbi [Relationship between GSTM1 and GSTT1 gene polymorphisms and noise induced hearing loss in Chinese workers]
    Miao Yang
    School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Wei Sheng Yan Jiu 34:647-9. 2005
    To investigate the relationship of GSTM1 and GSTT1 gene polymorphisms with the development of noise induced hearing loss (NIHL) in Chinese workers.
  12. ncbi Profile of polymorphisms of drug-metabolising enzymes and the risk of therapy-related leukaemia
    Pascual Bolufer
    Laboratory of Molecular Biology Medical Biopathology, Hospital Universitario La Fe, Valencia, Spain
    Br J Haematol 136:590-6. 2007
    ..analysed the prevalence of genetic polymorphisms of CYP1A1*2A(T6235C), CYP2E1*5B(C-1019T), CYP3A4*1B(A-290G), del{GSTT1}, del{GSTM1}, NQO1*2(C609T), MTHFR(C677T) and TYMS 2R/3R in 78 t-AML/t-MDS and 458 normal individuals (control ..
  13. ncbi Polymorphisms of glutathione S-transferase mu1 (GSTM1) and theta 1 (GSTT1) genes in chronic myeloid leukaemia
    Gustavo J Lourenco
    Eur J Haematol 75:530-1. 2005
  14. ncbi Cytochrome P4501A1 and glutathione S transferase gene polymorphisms in patients with aplastic anemia in India
    B Poonkuzhali
    Department of Haematology, Christian Medical College, Vellore, India
    Acta Haematol 114:127-32. 2005
    ..We analyzed the impact of the polymorphisms in CYP4501A1 and GSTM1 and GSTT1 genes on the susceptibility and disease severity in 200 patients with AA and compared the frequency with the ..
  15. doi Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia
    M S Goncalves
    Fundação Oswaldo Cruz FIOCRUZ Centro de Pesquisa Gonçalo Moniz CPqGM Pathology and Molecular Biology Laboratory, Rua Waldemar Falcão, Candeal, Salvador Bahia Brasil
    Int J Lab Hematol 32:e49-56. 2010
    ..We investigated the theta (GSTT1) and mu (GSTM1) null genotypes in a group of leukopenic subjects and normal subjects from Northeast Brazil, ..
  16. ncbi Glutathione S-transferase gene polymorphisms in presbycusis
    Nurcan Aras Ates
    Department of Medical Biology and Genetics, Mersin University School of Medicine, Mersin, Turkey
    Otol Neurotol 26:392-7. 2005
    ..The effect of aging shows a wide interindividual range; we aimed to investigate whether profiles of (glutathione S-transferase (GST) M1, T1 and P1 genotypes may be associated with the risk of age-related hearing loss...
  17. ncbi Xenobiotic gene polymorphisms and susceptibility to multiple myeloma
    Lisa F Lincz
    Haematologica 89:628-9. 2004
    ....
  18. ncbi Gluthatione-S-transferase T1-null genotype predisposes adults to acute promyelocytic leukemia; a case-control study
    Ali Mandegary
    Pharmaceutics Research Center, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
    Asian Pac J Cancer Prev 12:1279-82. 2011
    ..Particularly concerning acute promyelocytic leukemia (APL), the studies on association between GSTM1, GSTT1 and GSTP1 and the disease predisposition are scarce and contradictory...
  19. doi Role of glutathione-S-transferase (GST) polymorphisms in patients with advanced Hodgkin lymphoma: results from the HD2000 GISL trial
    Fortunato Morabito
    UOC di Ematologia, Dipartimento Oncoematologico, Azienda Ospedaliera, Cosenza, Italy
    Leuk Lymphoma 53:406-10. 2012
    ..We aimed to validate the impact of GSTT1 and GSTM1 deletions and of the GSTP1Ile105Val polymorphism on outcome and toxicity in 140 patients with advanced ..
  20. ncbi Polymorphisms of glutathione S-transferase mu1 (GSTM1) and theta1 (GSTT1) genes in multiple myeloma
    Manoela M Ortega
    Department of Internal Medicine, State University of Campinas, Sao Paulo, Brazil
    Acta Haematol 109:108-9. 2003
  21. doi A case control study of gene environmental interaction in fetal growth restriction with special reference to organochlorine pesticides
    Esha Sharma
    Department of Obstetrics and Gynaecology, University College of Medical Sciences and G T B Hospital, University of Delhi, Dilshad Garden, Delhi, India
    Eur J Obstet Gynecol Reprod Biol 161:163-9. 2012
    ..The objectives of the present study were (i) to determine the frequencies of polymorphic alleles of GSTM1 and GSTT1 genes in women with idiopathic FGR, (ii) to analyze the maternal and cord blood levels of the OCPs, and (iii) to ..
  22. ncbi Increased risk for acute myeloid leukaemia in individuals with glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) gene defects
    V R Arruda
    Department of Internal Medicine, State University of Campinas, Campinas, Sao Paulo, Brazil
    Eur J Haematol 66:383-8. 2001
    ..Both the GST mu 1 (GSTM1) and GST theta 1 (GSTT1) genes have a null variant allele in which the entire gene is absent...
  23. ncbi Increased risk for therapy-associated hematologic malignancies in patients with carcinoma of the breast and combined homozygous gene deletions of glutathione transferases M1 and T1
    Detlef Haase
    Department of Hematology and Oncology, Georg August University, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Leuk Res 26:249-54. 2002
    ..The control group consisted of 239 healthy individuals with comparable composition as to race and sex. GSTM1 and GSTT1 were analyzed by multiplex PCR. Comparison between patients and control group revealed a significant (P=0...
  24. doi Pharmacogenetic influence of GST polymorphisms on anthracycline-based chemotherapy responses and toxicity in breast cancer patients: a multi-analytical approach
    Sonam Tulsyan
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226 014, India
    Mol Diagn Ther 17:371-9. 2013
    ..The aim of this study was to determine the role of genetic variations in GST in predicting response to, and toxicity of, anthracycline-based chemotherapy in breast cancer patients...
  25. doi Association of glutathione S-transferase polymorphisms (GSTM1 and GSTT1) with primary open-angle glaucoma: an evidence-based meta-analysis
    Wenbin Huang
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat Sen University, Guangzhou, People s Republic of China
    Gene 526:80-6. 2013
    ..Therefore, a meta-analysis was performed to clarify the effects of GSTM1 and GSTT1 polymorphisms on POAG risk...
  26. pmc Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes
    Marika Bogdani
    Pacific Northwest Diabetes Research Institute, 720 Broadway, Seattle, Washington 98122, USA
    J Endocrinol 216:111-23. 2013
    ..genes involved in ROS metabolism, including glutathione S-transferase (GST) family members (Gstm2, Gstm4, Gstm7, Gstt1, Gstp1, and Gstk1), superoxide dismutases (Sod2 and Sod3), peroxidases, and peroxiredoxins...
  27. pmc Prevalence of glutathione S-transferase gene deletions and their effect on sickle cell patients
    Pandey Sanjay
    Department of Hematology, All India Institute of Medical Sciences AIIMS, New Delhi, India
    Rev Bras Hematol Hemoter 34:100-2. 2012
    ..Due to the different pathophysiology of anemia in thalassemia and sickle cell disease, there are significant differences in the pathophysiology of iron overload and iron-related complications in these disorders...
  28. pmc Association between cataract and genetic polymorphisms of GSTM1, GSTT1, and GSTO2 with respect of work place
    Iraj Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Mol Vis 18:1996-2000. 2012
    To investigate whether genetic polymorphisms of glutathione S-transferases (GSTM1, GSTT1, and GSTO2) in relation to the work place contribute to the development of cataract.
  29. ncbi Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin
    R McLeod
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom
    Cancer Res 57:4257-66. 1997
    ..The effect of selenium insufficiency is pleiotropic, and it was also noted that the theta-class GSTT1 is overexpressed 3- and 10-fold in livers of selenium-deficient Hooded Lister and Fischer 344 rats...
  30. doi Audioprofiles and antioxidant enzyme genotypes in presbycusis
    Simon I Angeli
    Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Laryngoscope 122:2539-42. 2012
    ..Audiometric patterns have been shown to indirectly provide information regarding the pathophysiology of presbycusis and be useful in the phenotyping of hereditary deafness...
  31. ncbi Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study
    M Stanulla
    Department of Pediatric Hematology and Oncology, Children s Hospital, Hannover Medical School, Hannover, Germany
    Blood 95:1222-8. 2000
    ..In a case-control study, we investigated the association between polymorphisms within the GSTM1, GSTT1, and GSTP1 genes and risk of relapse in childhood acute lymphoblastic leukemia (ALL). Cases were relapsed patients...
  32. doi Are glutathione S-transferase polymorphisms (GSTM1, GSTT1) associated with primary open angle glaucoma? A meta-analysis
    Yan Lu
    Department of Ophthalmology, Jinling Hospital, Nanjing University, PR China
    Gene 527:311-5. 2013
    ..However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association between GSTM1 and GSTT1 null genotypes and the risk for POAG.
  33. doi Glutathione S-transferase T1-null seems to be associated with graft failure in hematopoietic SCT
    R Elhasid
    Pediatric Hemato Oncology and Bone Marrow Transplant Department, Meyer Children s Hospital, Rambam Health Care Campus, 8 Ha liyah Strteet, Haifa, Israel
    Bone Marrow Transplant 45:1728-31. 2010
    ..This study presents data suggesting the involvement of glutathione S-transferase theta-1 (GSTT1), a phase II detoxifying enzyme encoded by GSTT1, in Ab-mediated rejection of HSCT in children with congenital ..
  34. doi Gene-environment interaction in preterm delivery with special reference to organochlorine pesticides
    M D Mustafa
    1Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad Garden, Delhi 110 095, India
    Mol Hum Reprod 19:35-42. 2013
    We investigated the association between glutathione S-transferases mu1 (GSTM1), theta 1 (GSTT1), Cytochrome P450IA1-T6235C (rs4646903, CYP1A1m1) and CYP1A1-1462V (rs1048943, CYP1A1m2) gene polymorphisms, and organochlorine pesticides (..
  35. ncbi The impact of smoking on clinical features of Behçet's disease patients with glutathione S-transferase polymorphisms
    H T E Ozer
    Department of Medicine, Division of Rheumatology Immunology, Cukurova University, Faculty of Medicine, Balcali, Adana, Turkey
    Clin Exp Rheumatol 30:S14-7. 2012
    ..In the present study the effect of smoking on clinical features of Behçet's disease were investigated in patients having GST-M1 and/or -T1 null polymorphisms...
  36. ncbi Dichloromethane mediated in vivo selection and functional characterization of rat glutathione S-transferase theta 1-1 variants
    D Gisi
    Institut fur Mikrobiologie, Eidgenossische Technische Hochschule Zurich, Switzerland
    Eur J Biochem 268:4001-10. 2001
    ..These results provide the first experimental evidence for the involvement of Gln102 and Arg107 in catalysis, and illustrate the potential of in vivo approaches to identify catalytic residues in GSTs whose activity leads to toxic effects...
  37. ncbi Impact of glutathione S-transferase gene deletion on early relapse in childhood B-precursor acute lymphoblastic leukemia
    Mami Takanashi
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan
    Haematologica 88:1238-44. 2003
    ..However, results of previous reports have been controversial. This study was undertaken to clarify the influence of GST polymorphism on the outcome of childhood B-precursor acute lymphoblastic leukemia (ALL)...
  38. ncbi Rat liver theta-class glutathione S-transferases T1-1 and T2-2: their chromatographic, electrophoretic, immunochemical, and functional properties
    A Hiratsuka
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Hachioji shi, 192 03, Japan
    Anal Biochem 252:229-37. 1997
    ..Cumene hydroperoxide was a better substrate for rGST T1-1 than for rGST T2-2, while the fatty acid hydroperoxides were the better substrates for rGST T2-2 than for rGST T1-1...
  39. ncbi Glutathione S-transferase: genetics and role in toxicology
    R C Strange
    Clinical Biochemistry Research Group, School of Postgraduate Medicine, Keele University, North Staffordshire Hospital, Stoke on Trent, UK
    Toxicol Lett 112:357-63. 2000
    ..Thus, GST genotypes alone and in combination have been linked with clinical outcome...
  40. doi Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a North Indian population
    Hariom Singh
    Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
    Am J Obstet Gynecol 198:303.e1-6. 2008
    The objective of the study was to evaluate the influence of genetic polymorphisms of GSTM1, GSTT1, and GSTM3 on the susceptibility of cervical cancer.
  41. ncbi Homozygous gene deletions of the glutathione S-transferases M1 and T1 are associated with thimerosal sensitization
    G A Westphal
    Abteilung für Arbeits und Sozialmedizin, Georg August Universitat Gottingen, Germany
    Int Arch Occup Environ Health 73:384-8. 2000
    ..Thus detoxification by polymorphically expressed glutathione S-transferases such as GSTT1 and GSTM1 might have a protective effect against sensitization by these substances.
  42. ncbi [Genetic polymorphism in glutathione S-transferase M1 and T1 in children with bronchial asthma]
    V A Vavilin
    Institute of Molecular Biology and Biophysics Siberian Branch of RAMS, Novosibirsk, Russia
    Vopr Med Khim 46:388-97. 2000
    ..of homozygous deletions of the glutathione S-transferase class mu and theta genes (null genotypes, GSTM1"-" and GSTT1"-", respectively)...
  43. ncbi Genetic polymorphisms of glutathione S-transferases and disease activity of rheumatoid arthritis
    P Bohanec Grabar
    Institute of Biochemistry, Faculty of Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia
    Clin Exp Rheumatol 27:229-36. 2009
    Glutathione S-transferases (GST); GST-mu1 (GSTM1), GST-pi1 (GSTP1) and GST-theta1 (GSTT1) have peroxidase activity towards cytotoxic metabolites produced in inflammatory reactions, the main feature of rheumatoid arthritis (RA)...
  44. doi Genetic polymorphism of GSTT1 and GSTM1 and susceptibility to chronic obstructive pulmonary disease (COPD)
    Mona M Faramawy
    Second year Medical student of Dubai Medical College for Girls, Dubai, United Arab Emirates
    J Crit Care 24:e7-10. 2009
    ..Nevertheless, only 10% to 20% of chronic smokers develop the severe impairment of pulmonary functions associated with COPD. This indicates the presence of genetic predisposing factors in its pathogenesis...
  45. doi The glutathione-S-transferase gene polymorphisms (Gstt1, Gstm1, and Gstp1) in patients with non-allergic nasal polyposis
    Cengiz Ozcan
    Department of Otorhinolaryngology, School of Medicine, Mersin University, Ihsaniye mahallesi 123 cad 4931 sokak, 33079 Mersin, Turkey
    Eur Arch Otorhinolaryngol 267:227-32. 2010
    ..We aimed to investigate the relationship between GST subgroup (GSTT1, GSTM1, and GSTP1) polymorphisms, and NP development...
  46. doi Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children
    Jayong Chung
    Department of Food and Nutrition and Research Institute of Science for Human Life, College of Human Ecology, Kyung Hee University, Seoul, Korea
    Clin Chem Lab Med 47:1475-81. 2009
    ..Glutathione S-transferase (GST) enzymes are critical for detoxifying reactive oxygen species (ROS) and their products which have been implicated in the pathology of inflammatory diseases such as atopic dermatitis (AD)...
  47. doi Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1
    Abeer Shokeer
    Department of Biochemistry and Organic Chemistry, Uppsala University, BMC, Box 576, SE 75123 Uppsala, Sweden
    Biochim Biophys Acta 1800:466-73. 2010
    ..The C-terminal helix of the protein serves as a lid over the active site, and contributes several residues to the H-site...
  48. doi Glutathione S-transferase T1 gene deletion polymorphism and lung cancer risk in Chinese population: a meta-analysis
    Yadong Wang
    Henan Center For Disease Control and Prevention, South Section of East Agriculture Road, Zhengdong New Area, Zhengzhou 450016, PR China
    Cancer Epidemiol 34:593-7. 2010
    ..we evaluated reported studies of association between polymorphism of glutathione S-transferase T1 gene (GSTT1) and the risk of lung cancer in Chinese population...
  49. ncbi The role of glutathione-S-transferase polymorphisms in ovarian cancer survival
    Christina M Nagle
    Cancer and Population Studies Division, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, QLD 4029, Australia
    Eur J Cancer 43:283-90. 2007
    ..Common polymorphisms in the glutathione-S-transferase (GSTM1, GSTP1 and GSTT1) family have been implicated in chemoresistence and ovarian cancer survival...
  50. doi Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom
    Anant M Ghelani
    School of Science and Technology, Teesside University, Tees Valley, Middlesbrough, TS1 3BA, UK
    Rheumatol Int 31:1355-61. 2011
    ..002) genotypes were associated with RA. In the majority of cases, recessive and multiplicative modes of inheritance explained the observed associations. This study demonstrates that ethnicity affects the genetic associations in RA...
  51. doi Non-Jewish Israeli IBD patients have significantly higher glutathione S-transferase GSTT1-null frequency
    Amir Karban
    Internal Medicine C, Rambam Health Care Campus, P O Box 9602, Haifa, 31096, Israel
    Dig Dis Sci 56:2081-7. 2011
    ..Two members of the glutathione S-transferase (GST) family of enzymes, GSTM1 and GSTT1, known to take part in cellular protection against electrophiles, demonstrate common deletion variants (termed ..
  52. pmc Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma
    Seif O Shaheen
    Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 126:1141-8.e7. 2010
    ..Demonstration of biologically plausible interactions between these exposures and maternal and child antioxidant gene polymorphisms would strengthen causal inference...
  53. pmc Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritis
    Brendan T Keenan
    Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 62:3196-210. 2010
    ..This study was undertaken to examine the impact of gene-smoking interactions on susceptibility to rheumatoid arthritis (RA)...
  54. pmc GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma
    Ahmed Abbas
    GRECAN EA1772, UFR des Sciences Pharmaceutiques, Universite de Caen Basse Normandie et Centre Francois Baclesse, Avenue du General Harris, 14076 Caen Cedex 05, France
    World J Gastroenterol 10:3389-93. 2004
    ..To evaluate the association between CYP1A1 and GSTs genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma (SCC) and esophageal adenocarcinoma (ADC) in a high risk area of northwest of France...
  55. ncbi Molecular cloning and amino acid sequencing of rat liver class theta glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters of carcinogenic arylmethanols
    K Ogura
    Department of Hygienic Chemistry, Tokyo College of Pharmacy, Japan
    Biochem Biophys Res Commun 181:1294-300. 1991
    ..W. 27,311) had only a weak homology (19-23%) with those of rat liver classes alpha, mu, and pi GST isozymes. Thus, the first evidence for the molecular cloning of the class theta GST was provided...
  56. pmc Theta, a new class of glutathione transferases purified from rat and man
    D J Meyer
    University College and Middlesex School of Medicine, Department of Biochemistry, London, U K
    Biochem J 274:409-14. 1991
    ..Natl. Acad. Sci. U.S.A. 87, 31-35] and the dichloromethane dehalogenase of Methylobacterium DM4 [La Roche & Leisinger (1990) J. Bacteriol, 172, 164-171]...
  57. ncbi Isolation and characterization of the gene encoding rat class theta glutathione S-transferase subunit yrs
    K Ogura
    Department of Drug Metabolism and Molecular Toxicology, Tokyo College of Pharmacy, Japan
    Biochem Biophys Res Commun 205:1250-6. 1994
    ..The present study provides the first evidence for the primary structure of the gene encoding a class theta GST subunit...
  58. pmc The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human
    G W Mainwaring
    Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, U K
    Biochem J 318:297-303. 1996
    ..Although the distribution of GSTT2-2 in rat liver was similar to that seen in the mouse, GSTT1-1 was not localized in a specific cell type or in the nuclei of either rat or human liver...
  59. ncbi Glutathione S-transferase activity and subunit composition in transitional cell cancer and mucosa of the human bladder
    C L Berendsen
    Department of Urology, Free University Hospital, Amsterdam, The Netherlands
    Urology 49:644-51. 1997
    ..GST activity and isoenzyme levels were studied in TCC and normal bladder mucosa...
  60. pmc Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1
    P J Sherratt
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 335:619-30. 1998
    ..The level of the GSTT1 subunit within tissues is an important determinant of susceptibility to the carcinogenic effects of these ..
  61. ncbi Glutathione S-transferase mu and theta polymorphisms and breast cancer susceptibility
    M Garcia-Closas
    M García Closas, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 91:1960-4. 1999
    The enzymes encoded by the glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) genes are involved in the metabolism (mainly inactivation, but activation is possible) of a wide range of carcinogens that are ubiquitous in the ..
  62. ncbi Variability and validity of polymorphism association studies in Parkinson's disease
    E K Tan
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Neurology 55:533-8. 2000
    ..In recent years, interest in gene-environment interactions has spurred a great number of association studies on polymorphism of different genes...
  63. ncbi Glutathione S-transferase genotypes in systemic sclerosis and their association with clinical manifestations in early disease
    M B Tew
    Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center Houston, TX 77030, USA
    Genes Immun 2:236-8. 2001
    ..or =5 years) were more likely than ethnically-matched normal controls to have null alleles for GSTM1 (M1) and/or GSTT1 (T1), and if the null allele status correlated with any major disease features...
  64. ncbi Glutathione transferase theta 1-1-dependent metabolism of the water disinfection byproduct bromodichloromethane
    Matthew K Ross
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Chem Res Toxicol 16:216-26. 2003
    ..Comparisons with CH(2)Cl(2) suggest that the reactive intermediates specific to GSH conjugation of CHBrCl(2) are more mutagenic/genotoxic than those derived from CH(2)Cl(2)...
  65. pmc Glutathione S-transferases M1-1 and T1-1 as risk modifiers for renal cell cancer associated with occupational exposure to chemicals
    L Buzio
    Dept of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Parma, Italy
    Occup Environ Med 60:789-93. 2003
    To investigate the possible interaction between occupational risk factors and genotype for glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) in renal cell cancer (RCC).
  66. ncbi Possible gene dosage effect of glutathione-S-transferases on atopic asthma: using real-time PCR for quantification of GSTM1 and GSTT1 gene copy numbers
    Charlotte Brasch-Andersen
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, University of Southern Denmark, Odense, Denmark
    Hum Mutat 24:208-14. 2004
    ..A real-time PCR assay for relative quantification of gene copy number of GSTM1 and GSTT1 was developed...
  67. ncbi Glutathione S-transferase T1 deletion is a risk factor for developing end-stage renal disease in diabetic patients
    Yu Yang
    Department of Molecular Medicine, China Medical University Hospital, 2, Yur Der Road, Taichung, Taiwan
    Int J Mol Med 14:855-9. 2004
    ..of two endogenous antioxidant genes, glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1), and to determine their role in the development of ESRD in diabetic and hypertensive patients...
  68. doi Glutathione S-transferase T1- and M1-null genotypes and coronary artery disease risk in patients with Type 2 diabetes mellitus
    Samantha Manfredi
    National Research Council, Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Pharmacogenomics 10:29-34. 2009
    ..We assessed the potential glutathione S-transferase (GST) gene-gene (GSTM1(null)-GSTT1(null)) and gene-smoking interactions on the development of CAD in patients with Type 2 diabetes.
  69. ncbi Increased cardiovascular morbidity and mortality in type 2 diabetes is associated with the glutathione S transferase theta-null genotype: a Go-DARTS study
    Alex S F Doney
    Institute for Cardiovascular Research, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, Scotland
    Circulation 111:2927-34. 2005
    ..We prospectively determined smoking-related cardiovascular morbidity by GST genotype in a large cohort of individuals with type 2 diabetes using a population-based diabetes research database (DARTS)...
  70. ncbi Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children
    G F Korytina
    Institute of Biochemistry and Genetics, Ufa Scientific Center, Pr Oktyabrya, 69, Ufa, 450054, Russia
    J Mol Med (Berl) 83:700-10. 2005
    ..Polymorphisms in the genes encoding CYP1A1, CYP2E1, EPHX1, GSTM1, GSTT1, and GSTP1 were investigated in cases of Tatar children with chronic bronchitis (n=129) and relapsing pneumonia (n=..
  71. ncbi A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus
    Tony Hayek
    Lipid Research Unit, Rambam Medical Center, The Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Atherosclerosis 184:404-12. 2006
    ..Our aim was firstly, to examine the association between the GST M1/GST mu-1 (GSTM1) and GST T1/GST theta-1 (GSTT1) gene variants with markers of oxidative stress and inflammation in diabetic patients, and secondly to examine the ..
  72. pmc T null and M null genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking
    Khaled K Abu-Amero
    Department of Genetics, King Faisal Specialist Hospital and Research Centre MBC 03, P O Box 3354, Riyadh 11211, Saudi Arabia
    BMC Med Genet 7:38. 2006
    The association of the deletion in GSTT1 and GSTM1 genes with coronary artery disease (CAD) among smokers is controversial. In addition, no such investigation has previously been conducted among Arabs.
  73. pmc An evolutionary perspective on glutathione transferases inferred from class-theta glutathione transferase cDNA sequences
    S E Pemble
    Department of Biochemistry and Molecular Biology, University College London, U K
    Biochem J 287:957-63. 1992
    ....
  74. ncbi Analysis of polymorphisms of tumor necrosis factor-alpha and polymorphic xenobiotic metabolizing enzymes in inflammatory bowel disease: study from northern India
    Rama D Mittal
    Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
    J Gastroenterol Hepatol 22:920-4. 2007
    ..The present study aimed to evaluate the effect of polymorphism of the TNF-alpha promoter at the -308 site, GSTM1 and GSTT1 in patients with IBD and healthy controls from northern India.
  75. ncbi GSTM1 and GSTT1 polymorphisms and the risk of prostate cancer in a Caribbean population of African descent
    Stéphane Mallick
    Department of Urology, University Hospital, Pointe a Pitre, Guadeloupe
    Urology 69:1165-9. 2007
    To investigate whether the glutathione S-transferase polymorphisms GSTM1 and/or GSTT1 contribute to prostate cancer risk in a Caribbean population of African descent in Guadeloupe.
  76. ncbi Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study
    L E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 28:1960-4. 2007
    ..polymorphisms including the GSTM1 deletion, GSTM3 3 bp deletion (IVS6 + 22-AGG) and V224I G>A substitution, GSTT1 deletion and the GSTP1 I105V A>G substitution...
  77. ncbi Combined glutathione S-transferase T1 and M1 positive genotypes afford protection against type 2 diabetes in Japanese
    Masaharu Hori
    Kumamoto University, Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Sciences, Oe honmachi 5 1, Kumamoto, 862 0973, Japan
    Pharmacogenomics 8:1307-14. 2007
    ..The aim of this study is to determine the association between the incidence of Type 2 diabetes and gene polymorphisms of glutathione S-transferase (GST), which modulates oxidative stress...
  78. ncbi GSTT1, GSTM1 and GSTP1 polymorphisms and susceptibility to juvenile idiopathic arthritis
    P Rohr
    Departamento de Genética e Programa de Pós graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
    Clin Exp Rheumatol 26:151-5. 2008
    In this study we have analyzed GSTM1, GSTT1 and GSTP1 polymorphisms in patients with juvenile idiopathic arthritis (JIA), to investigate a possible role of these genes as genetic components of the disease.
  79. pmc Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer
    Jian Min Yuan
    The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 29:1386-93. 2008
    ..The associations between the genotypes of glutathione S-transferase (GST) M1, GSTP1, GSTT1 and N-acetyltransferase (NAT) 1 and the phenotypes of NAT2 and cytochrome P450 (CYP) 1A2 and bladder cancer risk ..
  80. pmc Glutathione S-transferase M1 and T1 polymorphisms may predict adverse effects after therapy in children with medulloblastoma
    Nadia Barahmani
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Neuro Oncol 11:292-300. 2009
    ..We investigated the relationship between GSTM1 and GSTT1 polymorphisms and survival and toxicity in 42 children with medulloblastoma diagnosed and treated at the Texas ..

Research Grants5

  1. THERAPY-RELATED LEUKEMIA--CLINICAL/BIOLOGIC PREDICTORS
    Stella Davies; Fiscal Year: 2002
    ..The identification of markers of early progression to t-MDS/AML during or after therapy will also allow modification of therapy and/or the development of treatment with chemopreventive agents such as retinoids. ..
  2. DIETARY FACTORS IN THE ETIOLOGY OF CANCER IN SHANGHAI
    Jian Min Yuan; Fiscal Year: 2006
    ..In all instances of diet-cancer investigations, relevant genes with potential modifying effects on the respective diet-cancer associations will be included in the investigations. ..
  3. Dietary Factors in the Etiology of Colorectal Cancer
    Jian Min Yuan; Fiscal Year: 2008
    ..The potential modifying effects of HAA activating genes and tea polyphenols on the HAA-colorectal cancer association will be explored. [unreadable] [unreadable]..
  4. THE SINGAPORE COHORT STUDY OF DIET AND CANCER
    Jian Min Yuan; Fiscal Year: 2009
    ....