Gria1

Summary

Gene Symbol: Gria1
Description: glutamate ionotropic receptor AMPA type subunit 1
Alias: GluA1, gluR-A, glutamate receptor 1, AMPA-selective glutamate receptor 1, GluR1, gluR-1, gluR-K1, glutamate receptor A, glutamate receptor subunit GluR1, glutamate receptor, ionotropic, AMPA 1, glutamate receptor, ionotropic, AMPA1 (alpha 1)
Species: rat

Top Publications

  1. pmc Sustained hypertension increases the density of AMPA receptor subunit, GluR1, in baroreceptive regions of the nucleus tractus solitarii of the rat
    Sam M Hermes
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Brain Res 1187:125-36. 2008
  2. ncbi Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS
    B Sommer
    Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, F R G
    Science 249:1580-5. 1990
  3. ncbi Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II
    A L Mammen
    Howard Hughes Medical Institute, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 272:32528-33. 1997
  4. ncbi PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
    Jose A Esteban
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 6:136-43. 2003
  5. ncbi Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation
    Michael C Oh
    Vollum Institute, Oregon Health and Sciences University, Portland, 97239, USA
    J Biol Chem 281:752-8. 2006
  6. pmc Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons
    Hisaaki Namba
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Mol Cell Neurosci 31:628-41. 2006
  7. pmc Regulation of {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit
    Heng Ye Man
    Howard Hughes Medical Institute and Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:3579-84. 2007
  8. ncbi Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking
    Hailan Hu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 131:160-73. 2007
  9. pmc Surface mobility of postsynaptic AMPARs tunes synaptic transmission
    Martin Heine
    CNRS, UMR 5091, Universite Bordeaux, Bordeaux, France
    Science 320:201-5. 2008
  10. doi Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors
    Jochen Schwenk
    Institute of Physiology II, University of Freiburg, Engesserstrasse 4, 79108 Freiburg, Germany
    Science 323:1313-9. 2009

Research Grants

Scientific Experts

Detail Information

Publications134 found, 100 shown here

  1. pmc Sustained hypertension increases the density of AMPA receptor subunit, GluR1, in baroreceptive regions of the nucleus tractus solitarii of the rat
    Sam M Hermes
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Brain Res 1187:125-36. 2008
    ..Within NTS, the GluR1 subunit of the AMPA receptor is found primarily in dendritic spines...
  2. ncbi Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS
    B Sommer
    Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, F R G
    Science 249:1580-5. 1990
    ..These results identify a switch in the molecular and functional properties of glutamate receptors operated by alternative splicing...
  3. ncbi Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II
    A L Mammen
    Howard Hughes Medical Institute, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 272:32528-33. 1997
    ..generated two phosphorylation site-specific antibodies to analyze the phosphorylation of the glutamate receptor GluR1 subunit. These antibodies recognize GluR1 only when it is phosphorylated on serine residues 831 or 845...
  4. ncbi PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
    Jose A Esteban
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 6:136-43. 2003
    ..We found that PKA phosphorylation of the AMPA receptor subunits GluR4 and GluR1 directly controlled the synaptic incorporation of AMPA receptors in organotypic slices from rat hippocampus...
  5. ncbi Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation
    Michael C Oh
    Vollum Institute, Oregon Health and Sciences University, Portland, 97239, USA
    J Biol Chem 281:752-8. 2006
    ..Using a quantitative assay of net serine 845 (Ser-845) phosphorylation in the GluR1 subunit of AMPARs, we investigated the relationship between phospho-Ser-845, GluR1 surface expression, and ..
  6. pmc Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons
    Hisaaki Namba
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Mol Cell Neurosci 31:628-41. 2006
    ..growth factor alpha (TGFalpha), EGF, or heparin-binding EGF (HB-EGF) down-regulated protein expression of the GluR1 AMPA receptor subunit in cultured neocortical neurons...
  7. pmc Regulation of {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit
    Heng Ye Man
    Howard Hughes Medical Institute and Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:3579-84. 2007
    ..studies have shown that activation of PKA regulates the membrane trafficking of the AMPA receptor Glu receptor 1 (GluR1) subunit, but the role of direct phosphorylation of GluR1 in regulating receptor redistribution is not clear...
  8. ncbi Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking
    Hailan Hu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 131:160-73. 2007
    ..Toward this aim, we have examined the role of NE in contextual memory formation and in the synaptic delivery of GluR1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-type glutamate receptors during long-..
  9. pmc Surface mobility of postsynaptic AMPARs tunes synaptic transmission
    Martin Heine
    CNRS, UMR 5091, Universite Bordeaux, Bordeaux, France
    Science 320:201-5. 2008
    ..Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses...
  10. doi Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors
    Jochen Schwenk
    Institute of Physiology II, University of Freiburg, Engesserstrasse 4, 79108 Freiburg, Germany
    Science 323:1313-9. 2009
    ..These results demonstrate that cornichons are intrinsic auxiliary subunits of native AMPARs and provide previously unknown molecular determinants for glutamatergic neurotransmission in the central nervous system...
  11. pmc The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complex
    Wenhua Liu
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 285:6101-8. 2010
    ..It provides a potential mechanism underlying the role of corticosteroid stress hormone in up-regulating excitatory synaptic efficacy in cortical neurons...
  12. doi LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expression
    Vanessa J Appleby
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, UK
    J Neurochem 116:530-43. 2011
    ..We compared the effects of transient depolarisation on the surface expression of GluA1 and GluA2 subunits of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor and found a preferential ..
  13. pmc P-chlorophenylalanine increases glutamate receptor 1 transcription in rat amygdala
    Lee Tran
    Institute for Biomedical Studies, Baylor University, Waco, Texas, USA
    Neuroreport 22:758-61. 2011
    ..with P-chlorophenylalanine, an inhibitor of tyrosine-5-hydroxylase, resulted in a 21-fold increase in glutamate receptor 1 (GluR1) mRNA expression in the amygdala...
  14. ncbi Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons
    S Shi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 105:331-43. 2001
    ..In hippocampus, most AMPA-Rs are hetero-oligomers composed of GluR1/GluR2 or GluR2/GluR3 subunits. Here we show that these AMPA-R forms display different synaptic delivery mechanisms...
  15. ncbi Postsynaptic receptor trafficking underlying a form of associative learning
    Simon Rumpel
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 308:83-8. 2005
    ..Thus, the encoding of memories in the lateral amygdala is mediated by AMPA receptor trafficking, is widely distributed, and displays little redundancy...
  16. pmc Crystal structure and association behaviour of the GluR2 amino-terminal domain
    Rongsheng Jin
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA, USA
    EMBO J 28:1812-23. 2009
    ..Here we show that AMPA receptor GluR1- and GluR2-ATDs form tightly associated dimers and, by the analysis of crystal structures of the GluR2-ATD, ..
  17. ncbi SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit
    A S Leonard
    Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706 1532, USA
    J Biol Chem 273:19518-24. 1998
    ..AMPA receptors are probably tetramers and are formed by two or more of the four AMPA receptor subunits GluR1-4. GluR1 possesses a C-terminal consensus sequence for interactions with PDZ domains of SAPs...
  18. ncbi Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking
    Hongju Wu
    Department of Neurobiology, University of Alabama, Birmingham, AL 35294 0021, USA
    J Biol Chem 277:30928-34. 2002
    ..form a trimeric complex with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor subunit, GluR1. These data suggest that SAP97 may serve as a molecular link between GluR1 and the actin-dependent motor protein ..
  19. ncbi Light microscopic study of GluR1 and calbindin expression in interneurons of neocortical microgyral malformations
    V N Kharazia
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford University, 300 Pasteur Drive, M016, Stanford, CA 94305, USA
    Neuroscience 120:207-18. 2003
    ..of GABAergic cells that co-express the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit and the calcium-binding protein, calbindin (CB)...
  20. ncbi A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins
    Tatsuo Suzuki
    Department of Neuroplasticity, Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Eur J Neurosci 21:339-50. 2005
    ..alpha-internexin, and N-methyl-D-aspartate (NMDA)-type glutamate receptor 2B and AMPA-type glutamate receptor (GluR1) subunits...
  21. doi Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures
    S Borbely
    Department of Physiology and Neurobiology, Eotvos Lorand University, H 1117, Budapest Pázmány Péter sétány 1 C, Hungary
    Neuroscience 159:358-68. 2009
    ..The glutamate receptor subunits NR1, NR2A, NR2B, GluR1, GluR1(flop), GluR2, and KA-2 were studied using the histoblotting method...
  22. pmc S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors
    Balakrishnan Selvakumar
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:16440-5. 2009
    ..S-nitrosylation of stargazin increases binding to the AMPAR subunit GluR1, causing increased surface expression of the AMPAR...
  23. doi AMPA receptor downregulation induced by ischaemia/reperfusion is attenuated by age and blocked by meloxicam
    S Montori
    Area de Biología Celular, Instituto de Biomedicina Universidad de León, 24071 Leon, Spain
    Neuropathol Appl Neurobiol 36:436-47. 2010
    ..study shows how age and treatment with an anti-inflammatory agent (meloxicam) modify the levels of AMPAR subunits GluR1 and GluR2, as well as the mRNA levels of the GluR2-editing enzyme, ADAR2, in a global brain ischaemia/reperfusion (..
  24. doi Venus fly trap domain of mGluR1 functions as a dominant negative against group I mGluR signaling
    Donald Beqollari
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurophysiol 104:439-48. 2010
    ....
  25. doi Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses
    Yu Xia Chu
    Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
    Brain Behav Immun 24:1176-89. 2010
    ..increased expression of the microglial marker Iba-1, phosphorylated p38 (p-p38), interleukin 1β (IL-1β) and GluR1 following TSS...
  26. pmc Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation
    Patrick J Maier
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Biol Chem 285:35606-14. 2010
    ..This mechanism may relieve glutamatergic synapses from GABA(B) receptor-mediated inhibition resulting in increased synaptic excitability...
  27. pmc Endogenous GluR1-containing AMPA receptors translocate to asymmetric synapses in the lateral amygdala during the early phase of fear memory formation: an electron microscopic immunocytochemical study
    Hermina Nedelescu
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Comp Neurol 518:4723-39. 2010
    Although glutamate receptor 1 (GluR1)-containing α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (GluR1-AMPARs) are implicated in synaptic plasticity, it has yet to be demonstrated whether endogenous GluR1-AMPARs undergo ..
  28. doi Enhancement of AMPA currents and GluR1 membrane expression through PKA-coupled adenosine A(2A) receptors
    Raquel B Dias
    Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Portugal
    Hippocampus 22:276-91. 2012
    ..in the amplitude of miniature excitatory postsynaptic currents (mEPSCs), as well as in the membrane levels of GluR1 subunits phosphorylated at the PKA site (Ser845)...
  29. doi Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg
    J T T Kennard
    Department of Medicine RMH WH, University of Melbourne, Melbourne, Australia
    Neurobiol Dis 42:48-54. 2011
    ..We show that elevated stargazin in GAERS is associated with an increase in AMPA receptor proteins, GluA1 and GluA2 in the somatosensory cortex plasma membrane of adult epileptic GAERS...
  30. pmc Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability
    Fadi F Hamdan
    Centre of Excellence in Neuromics of Université de Montréal, Sainte Justine Hospital Research Centre, Montreal, Canada
    Am J Hum Genet 88:306-16. 2011
    ..None of these mutations or any other DNMs were identified in these genes in 285 healthy controls. This study highlights the importance of the glutamate receptor complexes in NSID and further supports the role of DNMs in this disorder...
  31. pmc The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines
    Grégory Gauvain
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche S 839, F75005 Paris, France
    Proc Natl Acad Sci U S A 108:15474-9. 2011
    ..This effect correlates with a reduced postsynaptic aggregation of GluR1-containing AMPA receptors and is mimicked by a dominant negative mutant of KCC2 interaction with cytoskeleton but ..
  32. pmc Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors
    Sandra D Santos
    CNC Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    J Biol Chem 287:6868-77. 2012
    ..Coexpression of Caspr1 with GluA1 increases the amplitude of glutamate-evoked currents...
  33. pmc Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation
    Dillon Y Chen
    Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 15:1707-14. 2012
    ..of CaMKIIα, TrkB, ERK, Akt, PLCγ and CREB, as well as a to a substantial induction of Arc and synaptic GluA1. Most of these changes, which are initiated by a nongenomic effect of glucocorticoid receptors, were also ..
  34. pmc S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis
    Balakrishnan Selvakumar
    Solomon H Snyder Department of Neuroscience and Departments of Psychiatry and Behavioral Sciences, Pharmacology and Molecular Sciences, and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 110:1077-82. 2013
    NMDA receptor activation can elicit synaptic plasticity by augmenting conductance of the AMPA receptor GluA1 subsequent to phosphorylation at S831 by Ca(2+)-dependent kinases...
  35. doi Hypoxia-induced retinal ganglion cell damage through activation of AMPA receptors and the neuroprotective effects of DNQX
    V Sivakumar
    Department of Anatomy, Yong Loo Lin School of Medicine, Blk MD10, 4 Medical Drive, National University of Singapore, Singapore 117597, Singapore
    Exp Eye Res 109:83-97. 2013
    ..b>GluR1-4 mRNA and protein expression showed a significant increase (P < 0...
  36. doi Involvement of pGluR1, EAAT2 and EAAT3 in offspring depression induced by prenatal stress
    X H Zhang
    Department of Pharmacology, College of Medicine, Xi an Jiaotong University, 86 710061 Shaanxi, China
    Neuroscience 250:333-41. 2013
    ..In this research, we examined the expression of phosphorylated GluR1 subunit of ionotropic receptor alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), the Na+-..
  37. pmc Depletion of serotonin in the basolateral amygdala elevates glutamate receptors and facilitates fear-potentiated startle
    L Tran
    Institute for Biomedical Studies, Baylor University, Waco, TX, USA
    Transl Psychiatry 3:e298. 2013
    ..The induction of low 5-HT in the LA elevated fear-potentiated startle, with a parallel increase in GluR1 mRNA and GluR1 protein expression...
  38. pmc The novel caspase-3 substrate Gap43 is involved in AMPA receptor endocytosis and long-term depression
    Meng Hsuan Han
    National Institute of Mental Health, Bethesda, Maryland 20892
    Mol Cell Proteomics 12:3719-31. 2013
    ..Our study has identified Gap43 as a key caspase-3 substrate involved in LTD and AMPA receptor endocytosis, uncovered a novel postsynaptic function for Gap43 and provided new insights into how long-term synaptic depression is induced. ..
  39. pmc Ca2+-permeable AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors and dopamine D1 receptors regulate GluA1 trafficking in striatal neurons
    David S Tukey
    From the Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York 10016
    J Biol Chem 288:35297-306. 2013
    ..acid receptors (AMPARs) into the postsynapse, a process mediated by GluA1 AMPAR subunit phosphorylation...
  40. pmc Endocytic adaptor epidermal growth factor receptor substrate 15 (Eps15) is involved in the trafficking of ubiquitinated α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors
    Amy Lin
    From the Department of Biology, Boston University, Boston, Massachusetts 02215
    J Biol Chem 289:24652-64. 2014
    ..Eps15 interacts with AMPARs, which requires Nedd4-mediated GluA1 ubiquitination and the ubiquitin-interacting motif of Eps15...
  41. pmc Intracellular Ca²⁺ and not the extracellular matrix determines surface dynamics of AMPA-type glutamate receptors on aspiny neurons
    Julia Klueva
    Research Group, Molecular Physiology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany Research Group, Presynaptic Plasticity, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Philos Trans R Soc Lond B Biol Sci 369:20130605. 2014
    ..Similarly, cross-linking with specific antibodies against the extracellular domain of the GluA1 receptor subunit, which affects lateral receptor mobility on spiny neurons, does not influence receptor mobility ..
  42. doi Prolonged glutamate excitotoxicity increases GluR1 immunoreactivity but decreases mRNA of GluR1 and associated regulatory proteins in dissociated rat retinae in vitro
    Michael Challenor
    Experimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, WA 6009, Australia School of Chemistry and Biochemistry, The University of Western Australia, WA 6009, Australia
    Biochimie 112:160-71. 2015
    ..RT-qPCR), to determine the effect of prolonged glutamate excitotoxicity on the expression of mRNA encoding for GluR1 and AMPA receptor regulatory proteins in dissociated rat retinal cultures that include neuronal (retinal ganglion ..
  43. doi Early onset of cognitive impairment is associated with altered synaptic plasticity and enhanced hippocampal GluA1 expression in a mouse model of depression
    Moshe Gross
    Department of Biochemistry and Molecular Biology, Tel Aviv University, Tel Aviv, Israel
    Neurobiol Aging 36:1938-52. 2015
    ..elevated protein levels of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA1 in the hippocampi of Sub mice, which was exacerbated with age...
  44. pmc Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38
    Alyssa M A Toda
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 112:6712-7. 2015
    ..pituitary adenylate cyclase activating polypeptide 38 (PACAP38) alters hippocampal CA1 synaptic strength and GluA1 synaptic localization, its effect on AMPAR phosphorylation state has not been explored...
  45. pmc PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons
    Rebecca M Dixon
    Medical Research Council MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 284:14230-5. 2009
    ....
  46. pmc Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression
    Hussam Jourdi
    Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, United States of America
    PLoS ONE 8:e57124. 2013
    ..Our results show that acute BDNF treatment upregulates the interactions between AMPAr subunits (GluR1 and GluR2) with their scaffold proteins SAP97 and GRIP1, respectively, leading to prolonged increased accumulation ..
  47. pmc PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP
    Si Qiang Ren
    Department of Neurobiology, Nanjing Medical University, Nanjing, People s Republic of China
    EMBO J 32:1365-80. 2013
    Direct phosphorylation of GluA1 by PKC controls α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor (AMPAR) incorporation into active synapses during long-term potentiation (LTP)...
  48. pmc Mechanisms of CaMKII action in long-term potentiation
    John Lisman
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Rev Neurosci 13:169-82. 2012
    ..These processes are all localized to stimulated spines and account for the synapse-specificity of LTP. In the later stages of LTP, CaMKII has a structural role in enlarging and strengthening the synapse...
  49. doi Spinal SGK1/GRASP-1/Rab4 is involved in complete Freund's adjuvant-induced inflammatory pain via regulating dorsal horn GluR1-containing AMPA receptor trafficking in rats
    Hsien Yu Peng
    Department of Medicine, Mackay Medical College, New Taipei, Taiwan
    Pain 153:2380-92. 2012
    ..SGK1) and downstream glutamate receptor interacting protein (GRIP)-associated protein-1 (GRASP-1)/Rab4-dependent GluR1-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) recycling play a role in ..
  50. pmc SUMOylation is required for glycine-induced increases in AMPA receptor surface expression (ChemLTP) in hippocampal neurons
    Nadia Jaafari
    School of Biochemistry, University of Bristol, Bristol, United Kingdom
    PLoS ONE 8:e52345. 2013
    ..Here we demonstrate that protein SUMOylation is required for insertion of the GluA1 AMPAR subunit following transient glycine-evoked increase in AMPA receptor surface expression (ChemLTP) in ..
  51. pmc Identification of a novel signaling pathway and its relevance for GluA1 recycling
    Guiscard Seebohm
    Department of Biochemistry I Cation Channel Group, Ruhr University Bochum, Bochum, Germany
    PLoS ONE 7:e33889. 2012
    ..showed that the serum- and glucocorticoid-inducible kinase 3 (SGK3) increases the AMPA-type glutamate receptor GluA1 protein in the plasma membrane...
  52. ncbi Molecular cloning and functional expression of glutamate receptor subunit genes
    J Boulter
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, San Diego, CA 92138
    Science 249:1033-7. 1990
    Three closely related genes, GluR1, GluR2, and GluR3, encode receptor subunits for the excitatory neurotransmitter glutamate...
  53. ncbi Cloning by functional expression of a member of the glutamate receptor family
    M Hollmann
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
    Nature 342:643-8. 1989
    ....
  54. ncbi Antibody specific for phosphorylated AMPA-type glutamate receptors at GluR2 Ser-696
    K Nakazawa
    Laboratory for Synaptic Function, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    Neurosci Res 24:75-86. 1995
    ..Another peptide containing Thr-692 of a rat GluRA, clone almost identical to GluR1, was phosphorylated by PKC but not by PKG...
  55. ncbi Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo
    M Wyszynski
    Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 19:6528-37. 1999
    ..Collectively, these findings support a role for GRIP in the synaptic anchoring of AMPA receptors but also suggest that GRIP has additional functions unrelated to the binding of AMPA receptors...
  56. pmc A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing
    P J Aruscavage
    Department of Biochemistry Howard Hughes Medical Institute, University of Utah, Salt Lake City 84132, USA
    RNA 6:257-69. 2000
    ..The approximately 600-nt intron 13 of gluR-C was particularly remarkable, showing >94% nucleotide identity between human and chicken, organisms estimated to have diverged 310 million years ago...
  57. ncbi The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway
    Tomoyuki Nishizaki
    Department of Physiology, Hyogo College of Medicine, 1 1 Mukogawa cho, 663 8501, Nishinomiya, Japan
    Brain Res Mol Brain Res 98:130-4. 2002
    ..on the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, heteromerically formed of GluR1,2 (GluR1 and GluR2), GluR1,3 (GluR1 and GluR3), and GluR1,2,3 (GluR1, GluR2, and GluR3), expressed in Xenopus ..
  58. ncbi The structure and function of glutamate receptor ion channels
    Dean R Madden
    Ion Channel Structure Research Group, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Nat Rev Neurosci 3:91-101. 2002
    ....
  59. pmc Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex
    Robert B Levy
    New York University Center for Neural Science, New York, New York 10003, USA
    J Neurosci 22:5001-15. 2002
    ..we used dual immunolabeling and electron microscopy to examine the distribution of alpha7nAChR relative to AMPAR (GluR1, GluR2, and GluR3 subunits combined) at excitatory synapses in somatosensory cortex of adult and 1-week-old rats...
  60. ncbi A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors
    Houhui Xia
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94304, USA
    J Biol Chem 277:47765-9. 2002
    ..assembly and surface expression, we have epitope-tagged the N-terminal domain of the AMPA receptor subunit, GluR1, and expressed it in human embryonic kidney 293 cells and hippocampal neurons...
  61. ncbi Co-localization of AMPA receptor subunits in the nucleus of the solitary tract in the rat
    Sue A Aicher
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Brain Res 958:454-8. 2002
    ..GluR2/3 was found at pre- and postsynaptic sites, and in astrocytic glia; while GluR1 was found primarily in small dendrites and spines...
  62. pmc Regulated delivery of AMPA receptor subunits to the presynaptic membrane
    Ursula Schenk
    CNR Institute of Neuroscience, Cellular and Molecular Pharmacology, Center of Excellence for Neurodegenerative Diseases, Department of Medical Pharmacology, Via Vanvitelli 32, 20129 Milano, Italy
    EMBO J 22:558-68. 2003
    ..We demonstrate that the AMPA receptor subunits GluR1 and GluR2 are expressed and organized in functional receptors in axonal growth cones of hippocampal neurons...
  63. ncbi Experience strengthening transmission by driving AMPA receptors into synapses
    Takuya Takahashi
    Jones Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 299:1585-8. 2003
    ..In vivo gene delivery was combined with in vitro recordings to show that experience drives recombinant GluR1, an AMPA-R subunit, into synapses formed between layer 4 and layer 2/3 neurons...
  64. ncbi Differential phosphorylation at serine sites in glutamate receptor-1 within neonatal rat hippocampus
    Ai Jun Li
    Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Neurosci Lett 341:41-4. 2003
    ..of alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA)-receptor glutamate receptor-1 (GluR1) and related protein kinases in rat hippocampus on postnatal days (PND) 1-28...
  65. pmc Characterization of the intracellular transport of GluR1 and GluR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons
    Pavel V Perestenko
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 278:43525-32. 2003
    ..Here, using virally expressed green fluorescent protein (GFP)-GluR1 and GFP-GluR2 and confocal photobleach techniques we show near real-time movement of these subunits in living ..
  66. ncbi Ischemia-induced alterations of AMPA-type glutamate receptor subunit. Expression patterns in the rat retina--an immunocytochemical study
    Frederike Dijk
    Glaucoma Research Group, Netherlands Ophthalmic Research Institute KNAW, Graduate School for the Neurosciences Amsterdam, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
    Brain Res 997:207-21. 2004
    ..ischemia/reperfusion leads to alterations in the expression of AMPA-type glutamate receptor (AMPAR) subunits GluR1-4...
  67. ncbi Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses
    Susumu Tomita
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143 2140, USA
    Science 303:1508-11. 2004
    ..This did not require ion flux or intracellular second messengers. This allosteric mechanism for AMPA receptor dissociation from TARPs may participate in glutamate-mediated internalization of receptors in synaptic plasticity...
  68. ncbi Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons
    Sang Hyoung Lee
    The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 43:221-36. 2004
    ..The intracellular accumulation of GluR2 and GluR3 but not GluR1 is enhanced by AMPA, NMDA, or synaptic activity...
  69. ncbi Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression
    Jing Du
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:6578-89. 2004
    ..dissimilar, antimanic agents lithium and valproate regulate synaptic expression of AMPA receptor subunit glutamate receptor 1 (GluR1)...
  70. ncbi Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals
    Fumino Fujiyama
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Japan
    Eur J Neurosci 20:3322-30. 2004
    ..Immunoreactive gold particles for AMPA receptor subunits GluR1 and GluR2/3 were frequently found not only on postsynaptic but also on presynaptic profiles immunopositive for ..
  71. ncbi Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs
    Susumu Tomita
    Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuron 45:269-77. 2005
    ..These results establish stargazin as a critical substrate in the bidirectional control of synaptic strength, which is thought to underlie aspects of learning and memory...
  72. ncbi Control of excitatory and inhibitory synapse formation by neuroligins
    Ben Chih
    Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Science 307:1324-8. 2005
    ..Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons...
  73. ncbi Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin
    Pieter H Anborgh
    Cell Biology Research Group, Robarts Research Institute and Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario N6A 5K8, Canada
    J Biol Chem 280:34840-8. 2005
    ..Taken together, these studies identify a novel mechanism for mGluR desensitization and an additional biochemical link between altered glutamate receptor signaling and Huntington disease...
  74. ncbi Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors
    Xiuwu Zhang
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 32:377-87. 2007
    ..were associated with parallel alterations in expression levels and/or phosphorylation changes in the NR2B and GluR1 subunits of the respective NMDA and AMPA receptors...
  75. ncbi Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity
    Jannic Boehm
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Learn Mem 13:562-5. 2006
    The regulated trafficking of GluR1 contributes significantly to synaptic plasticity, but studies addressing the function of the GluR1 C-terminal PDZ-ligand domain in this process have produced conflicting results...
  76. ncbi Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs
    Rebeca Martinez-Turrillas
    Division of Neurosciences, CIMA, School of Medicine, University of Navarra, Av Pio XII, 55, 31008 Pamplona, Spain
    Biochem Biophys Res Commun 353:750-5. 2007
    ..Both antidepressants increased the interaction of GluR1 subunit with stargazin and of GluR2/3 with NSF...
  77. ncbi Differential regulation of AMPA receptor trafficking by neurabin-targeted synaptic protein phosphatase-1 in synaptic transmission and long-term depression in hippocampus
    Xiao Dong Hu
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 27:4674-86. 2007
    ..Instead, NrbI-targeted PP1 facilitates LTD by dephosphorylating GluR1 at both serine 845 and serine 831, with GluR2 serine 880 phosphorylation unaltered...
  78. ncbi Spontaneously hypertensive rats are highly vulnerable to AMPA-induced brain lesions
    Clotilde Lecrux
    University of Caen, CNRS UMR 6185, Cyceron, Caen, France
    Stroke 38:3007-15. 2007
    ....
  79. ncbi Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus
    Kentaro Matsuzaki
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Eur J Pharmacol 578:194-200. 2008
    ..combined methods of biochemistry and electrophysiology, we examined the effects of nobiletin on phosphorylation of GluR1 receptor, the subunit of alpha-amino-3-hydroxy-5-methyl-D-aspartate (AMPA) receptors, and the receptor-mediated ..
  80. ncbi Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors
    André R Gomes
    Centre for Neuroscience and Cell Biology, Department of Zoology, University of Coimbra, Largo Marques de Pombal, 3004 517 Coimbra, Portugal
    Mol Cell Neurosci 37:323-34. 2008
    ..AMPA receptors form heterotetramers of four homologous subunits (GluR1-4), which exist in two functionally different isoforms, flip and flop, generated by alternative splicing...
  81. doi The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene
    Jonathan M Levenson
    Galenea, Corp, Cambridge, MA 02139, USA
    Biochim Biophys Acta 1779:422-31. 2008
    ....
  82. doi Role of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic nociception in rat
    Yue Lu
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, China
    Brain Res 1200:19-26. 2008
    The present study aims to investigate changes of spinal cord AMPA receptor GluR1 and its phosphorylation in inflammatory and neuropathic pain...
  83. pmc Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats
    Binbin Yan
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4000 Central Florida Parkway, Orlando, FL 32816, USA
    Am J Physiol Regul Integr Comp Physiol 296:R299-308. 2009
    ..CIH -238 +/- 27 beats/min, P < 0.05); and 3) the number of NMDAR1, AMPA GluR1, and AMPA GluR2/3-immunoreactive cells in the NA was reduced (P < 0.05)...
  84. pmc Paradoxical (REM) sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus
    Pascal Ravassard
    UMR 5167 CNRS, Physio pathologie des reseaux neuronaux du cycle veille sommeil, Institut Feddratifdes Neurosciences de Lyon IFNL, IFR 19, Universite Lyon, Lyon, France
    Sleep 32:227-40. 2009
    ..We examined whether PS modulated the excitatory transmission and expression of glutamate receptor subtypes and phosphorylated extracellular signal-regulated kinases (p-ERK1/2)...
  85. doi Activation of group I metabotropic glutamate receptors increases serine phosphorylation of GluR1 alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in the rat dorsal striatum
    Sung Min Ahn
    Department of Biological Sciences, Pusan National University, 30 Jangjeon dong, Kumjeong gu, Pusan 609 735, Korea
    J Pharmacol Exp Ther 329:1117-26. 2009
    ..study, we investigated the regulation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor GluR1 subunit phosphorylation by the stimulation of group I metabotropic glutamate receptors (mGluRs) in the rat dorsal ..
  86. pmc Activity level-dependent synapse-specific AMPA receptor trafficking regulates transmission kinetics
    J Julius Zhu
    Departments of Pharmacology and Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Neurosci 29:6320-35. 2009
    ..Moreover, GluR1-containing AMPA-Rs traffic selectively into intracortical synapses, and this process requires sensory experience-..
  87. pmc The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors
    Nael Nadif Kasri
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 23:1289-302. 2009
    ..Thus, our findings link genetic deficits in OPHN1 to glutamatergic dysfunction and suggest that defects in early circuitry development are an important contributory factor to this form of MR...
  88. pmc Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation
    Da Ting Lin
    Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 12:879-87. 2009
    ..By directly visualizing individual insertion events of the AMPAR subunit GluR1 in rodents, we found that the protein 4.1N was required for activity-dependent GluR1 insertion...
  89. doi Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate
    Yusuke Nakatsu
    Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima, 734 8553, Japan
    Toxicol Appl Pharmacol 240:292-8. 2009
    ..Long-term exposure to 20 nM TBT decreased the mRNA expression of glutamate receptors NR1, NR2A, GluR1 and GluR2, and increased that of NR2B, GluR3 and GluR4...
  90. doi Physical exercise improves learning by modulating hippocampal mossy fiber sprouting and related gene expression in a developmental rat model of penicillin-induced recurrent epilepticus
    Hong Ni
    Neurology Laboratory, Soochow University Affiliated Children s Hospital, Laboratory of Aging and Nervous Diseases, Soochow University, Suzhou 215003, PR China
    Toxicol Lett 191:26-32. 2009
    ..Both EXP1 and EXP2 rats had a higher amount of glutamate receptor 1 (GluR1) and lower amount of the ratio of GluR2/GluR1 in hippocampus when compared with CONT rats...
  91. doi Fast, quantitative in situ hybridization of rare mRNAs using 14C-standards and phosphorus imaging
    Christian M Cremer
    Institute for Neuroscience and Medicine INM 2, Research Center Julich, Julich, Germany
    J Neurosci Methods 185:56-61. 2009
    ..We used this approach as an example for applications to quantify the expression of GluR1 and GluR2 subunit mRNAs of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor in the ..
  92. pmc C-terminal domains of transmembrane alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor regulatory proteins not only facilitate trafficking but are major modulators of AMPA receptor function
    Charlotte Sager
    Department of Biochemistry I Receptor Biochemistry, Ruhr University Bochum, Germany
    J Biol Chem 284:32413-24. 2009
    ..We analyzed the impact of the resulting chimeras on GluR1 functional properties in Xenopus oocytes and HEK293 cells...
  93. pmc Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activity
    Yelyzaveta A Nikandrova
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:923-34. 2010
    Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) promotes trafficking and activation of the GluR1 subunit of alpha-amino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) during synaptic plasticity...
  94. ncbi Immunohistochemistry of GluR1 subunits of AMPA receptors of rat cerebellar nerve cells
    Orlando J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, PO Box 526, Maracaibo, Venezuela
    Biocell 33:71-80. 2009
    The localization of GluR1 subunits of ionotropic glutamate receptors in the glial cells and inhibitory neurons of cerebellar cortex and their association with the climbing and parallel fibers, and basket cell axons were studied...
  95. pmc Regulation of synaptic structure and function by palmitoylated AMPA receptor binding protein
    Charu Misra
    Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Cell Neurosci 43:341-52. 2010
    ..viral expression of pABP-L increased AMPAR mediated mEPSC amplitude and frequency and elevated surface levels of GluR1 and GluR2, suggesting an increase in AMPA receptors at individual synapses...
  96. doi Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF
    Midori Ninomiya
    Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Shinjuku ku, Tokyo, Japan
    Neurosci Lett 476:104-9. 2010
    ..Expression of glutamate receptors such as GluA1 and GluN2A was also suppressed in IUGR-rat cultures...
  97. ncbi [Effect of behavioral training on learning and memory capacity and changes of hippocampal NR2B and GluR1 expressions in FGR offspring rats]
    Pu Huang
    Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi an Jiaotong University Coolege of Medicine, Xi an 710061, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:708-11. 2010
    To study the effect of behavioral training on the learning and memory abilities and changes of NR2B and GluR1 expressions in the hippocampus of offspring rats with fetal growth retardation (FGR).
  98. pmc Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone
    Robert M Sears
    Department of Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 30:8263-73. 2010
    ..A reduction of phosphorylation of GluR1 at serine 845 (pSer(845)) is shown to occur after both pharmacological and genetic manipulations of MCHR1 activity...
  99. pmc Regulation of AMPA receptor trafficking and function by glycogen synthase kinase 3
    Jing Wei
    Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing 210009, Jiangsu Province, China
    J Biol Chem 285:26369-76. 2010
    ..Treatment with GSK-3 inhibitors also decreased surface and synaptic GluR1 clusters on dendrites and increased internalized GluR1 in cortical cultures...
  100. doi Differential roles of phosphorylated AMPA receptor GluR1 subunits at Serine-831 and Serine-845 sites in spinal cord dorsal horn in a rat model of post-operative pain
    Yun Wang
    Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, no 8, Gongtinan Road, Chaoyang District, 100020 Beijing, China
    Neurochem Res 36:170-6. 2011
    ..that the enhanced levels of phosphorylated α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor GluR1 subunits at Serine-831 (pGluR1-Ser-831) and Serine-845 (pGluR1-Ser-845) in the spinal cord dorsal horn are ..
  101. doi Increased synaptic GluR1 subunits in the anterior cingulate cortex of rats with peripheral inflammation
    Bihua Bie
    Department of General Anesthesiology, Institute of Anesthesiology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur J Pharmacol 653:26-31. 2011
    ..Furthermore, an increased distribution of the synaptic GluR1 subunit was observed in the ACC neurons...

Research Grants9

  1. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 2002
    ....
  2. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2007
    ..The insights derived are likely to be of importance in understanding diseases of memory and suggest strategies for therapeutic intervention. ..
  3. MECHANISMS OF LONG-TERM POTENTIATION
    John E Lisman; Fiscal Year: 2010
    ..Positive results would strongly argue that the CaMKII-NMDA complex is critical for the storage of synaptic memory and would set the stage for studying the role of this complex in the maintenance of behavioral memory. ..
  4. Novel pharmacotherapies for treatment of ADHD
    FRANK TARAZI; Fiscal Year: 2003
    ..Expected findings should evolve new principles and lead to novel compounds that can be used as much-needed innovative treatments for ADHD and other major neuropsychiatric disorders. ..
  5. Norepinephrine Transporters: Targets for ADHD
    FRANK TARAZI; Fiscal Year: 2004
    ..Expected findings should lead to novel compounds that can be developed as much needed innovative non-stimulant treatments for ADHD and other major neuropsychiatric disorders. ..
  6. Effects of antipsychotic drugs on brain and behavior
    FRANK TARAZI; Fiscal Year: 2005
    ..adult rats, and should evolve new principles for improved treatments for childhood-onset schizophrenia and other major pediatric psychiatric disorders. ..
  7. ANATOMICAL STUDIES OF BRAINSTEM CARDIOVASCULAR SYSTEMS
    Sue Aicher; Fiscal Year: 2007
    ..In our previous studies of AMPA receptors we made a surprising discovery: the number of GluR1 receptor subunits significantly increases in NTS following the development of hypertension...
  8. Hybrid Drugs: Novel Pharmacotherapy for ADHD
    FRANK TARAZI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. Mechanisms of Synaptic Depression: Focus on Rap Signaling Pathways
    J Julius Zhu; Fiscal Year: 2010
    ..abstract_text> ..