Gfpt1

Summary

Gene Symbol: Gfpt1
Description: glutamine fructose-6-phosphate transaminase 1
Alias: GFA, GFAT, GFAT1, GFAT1m, Gfpt, D-fructose-6-phosphate amidotransferase 1, GFAT 1, glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1, glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, glutamine:fructose 6 phosphate amidotransferase 1, glutamine:fructose-6-phosphate amidotransferase 1, hexosephosphate aminotransferase 1
Species: rat

Top Publications

  1. pmc Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia
    Rubina A Heptulla
    Department of Pediatrics, Division of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 94:1608-11. 2009
  2. ncbi Effects of diabetes and hyperglycemia on the hexosamine synthesis pathway in rat muscle and liver
    K A Robinson
    Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 44:1438-46. 1995
  3. ncbi Glutamine fructose-6-phosphate amidotransferase (GFAT) gene expression and activity in patients with type 2 diabetes: inter-relationships with hyperglycaemia and oxidative stress
    Vedantham Srinivasan
    Madras Diabetes Research Foundation and Dr Mohan s Diabetes Specialties Center 6B, Conran Smith Road, Gopalapuram, Chennai, India
    Clin Biochem 40:952-7. 2007
  4. ncbi Effect of sucrose and saturated-fat diets on mRNA levels of genes limiting muscle fatty acid and glucose supply in rats
    Andreu Ferrer-Martínez
    Department de Bioquimica i Biologia Molecular, Universitat de Barcelona, E 08028 Barcelona, Spain
    Lipids 41:55-62. 2006
  5. ncbi The cellular fate of glucose and its relevance in type 2 diabetes
    Clara Bouche
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocr Rev 25:807-30. 2004
  6. ncbi Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance
    G Veerababu
    Department of Medicine, University of Utah School of Medicine, Veterans Administration Medical Center, Salt Lake City 84132, USA
    Diabetes 49:2070-8. 2000
  7. ncbi Purification and characterization of glutamine:fructose 6-phosphate amidotransferase from rat liver
    Q K Huynh
    Searle Discovery Research, The Monsanto Life Sciences Company, 800 North Lindbergh Boulevard, St Louis, Missouri 63167, USA
    Arch Biochem Biophys 379:307-13. 2000
  8. ncbi Insulin stimulation of glutamine: fructose-6-phosphate amidotransferase occurs via an insulin-like growth factor-1 pathway in rat fibroblasts
    S T Simmons
    Department of Medicine, University of Mississippi Medical Center, Jackson 39216, USA
    Res Commun Mol Pathol Pharmacol 104:63-72. 1999
  9. ncbi Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes
    A G Nerlich
    Department of Pathology, University of Munich, Germany
    Diabetes 47:170-8. 1998
  10. ncbi Regulation of insulin-stimulated glycogen synthase activity by overexpression of glutamine: fructose-6-phosphate amidotransferase in rat-1 fibroblasts
    E D Crook
    Veterans Administration Medical Center, Birmingham, Alabama
    Diabetes 42:1289-96. 1993

Research Grants

Scientific Experts

  • Rubina Heptulla
  • Q K Huynh
  • Dorota Rogacka
  • Vedantham Srinivasan
  • Andreu Ferrer-Martínez
  • Clara Bouche
  • E D Crook
  • M C Daniels
  • D A McClain
  • G Veerababu
  • L F Hebert
  • S T Simmons
  • Viswanathan Mohan
  • Syed Farooq
  • Muthuswamy Balasubramanyam
  • Rangasamy Sampathkumar
  • Narasimhan Sandhya
  • Anna M Gómez-Foix
  • Mario Marotta
  • Marco Turini
  • A G Nerlich
  • Katherine Mace
  • Shanti Serdy
  • C Ronald Kahn
  • Allison B Goldfine
  • J Tang
  • R C Cooksey
  • R T Hoffman
  • K A Robinson
  • E Huddleston
  • E Wagner
  • E D Schleicher
  • U Sauer
  • V Kolm-Litty
  • M Koch
  • G E Lindenmayer
  • M L Weinstein
  • M G Buse
  • T M Smith

Detail Information

Publications11

  1. pmc Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia
    Rubina A Heptulla
    Department of Pediatrics, Division of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 94:1608-11. 2009
    ..The purpose of this study was to examine the effect of continuous sc replacement of amylin and insulin for a 24-h period on glucose homeostasis in adolescents with type 1diabetes...
  2. ncbi Effects of diabetes and hyperglycemia on the hexosamine synthesis pathway in rat muscle and liver
    K A Robinson
    Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 44:1438-46. 1995
    ..Glutamine:fructose-6- phosphate amidotransferase (GFAT) catalyzes glucose flux via HexSNP; its major products are uridine diphosphate (UDP)-N-acetyl hexosamines (UDP-..
  3. ncbi Glutamine fructose-6-phosphate amidotransferase (GFAT) gene expression and activity in patients with type 2 diabetes: inter-relationships with hyperglycaemia and oxidative stress
    Vedantham Srinivasan
    Madras Diabetes Research Foundation and Dr Mohan s Diabetes Specialties Center 6B, Conran Smith Road, Gopalapuram, Chennai, India
    Clin Biochem 40:952-7. 2007
    ..a role for the rate-limiting enzyme for hexosamine biosynthesis, glutamine:fructose-6-phosphate amidotransferase (GFAT) in insulin resistance...
  4. ncbi Effect of sucrose and saturated-fat diets on mRNA levels of genes limiting muscle fatty acid and glucose supply in rats
    Andreu Ferrer-Martínez
    Department de Bioquimica i Biologia Molecular, Universitat de Barcelona, E 08028 Barcelona, Spain
    Lipids 41:55-62. 2006
    ..genes that regulate the exogenous FA supply (LPL, FAT/CD36, FATP1), synthesis (ACC1), glucose (GLUT4, GLUT1, HK2, GFAT1, glycogen phosphorylase) or glycerol (glycerol kinase) provision, or substrate choice for oxidation (PDK4) in ..
  5. ncbi The cellular fate of glucose and its relevance in type 2 diabetes
    Clara Bouche
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocr Rev 25:807-30. 2004
    ..This review is focused on the cellular fate of glucose and relevance to human type 2 diabetes...
  6. ncbi Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance
    G Veerababu
    Department of Medicine, University of Utah School of Medicine, Veterans Administration Medical Center, Salt Lake City 84132, USA
    Diabetes 49:2070-8. 2000
    ..in liver, the rate-limiting enzyme in hexosamine biosynthesis (glutamine:fructose-6-phosphate amidotransferase [GFA]) was overexpressed in transgenic mice using the PEPCK promoter. Liver from random-fed transgenic mice had 1...
  7. ncbi Purification and characterization of glutamine:fructose 6-phosphate amidotransferase from rat liver
    Q K Huynh
    Searle Discovery Research, The Monsanto Life Sciences Company, 800 North Lindbergh Boulevard, St Louis, Missouri 63167, USA
    Arch Biochem Biophys 379:307-13. 2000
    ..6.1.16, GFAT) catalyzes the formation of glucosamine 6-phosphate from fructose 6-phosphate and glutamine...
  8. ncbi Insulin stimulation of glutamine: fructose-6-phosphate amidotransferase occurs via an insulin-like growth factor-1 pathway in rat fibroblasts
    S T Simmons
    Department of Medicine, University of Mississippi Medical Center, Jackson 39216, USA
    Res Commun Mol Pathol Pharmacol 104:63-72. 1999
    ..The rate limiting enzyme in this pathway is glutamine:fructose-6-phosphate amidotransferase (GFA)...
  9. ncbi Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes
    A G Nerlich
    Department of Pathology, University of Munich, Germany
    Diabetes 47:170-8. 1998
    ..Because glutamine:fructose-6-phosphate amidotransferase (GFAT) catalyzes the first and rate-limiting step in the formation of hexosamine products, this enzyme is the key ..
  10. ncbi Regulation of insulin-stimulated glycogen synthase activity by overexpression of glutamine: fructose-6-phosphate amidotransferase in rat-1 fibroblasts
    E D Crook
    Veterans Administration Medical Center, Birmingham, Alabama
    Diabetes 42:1289-96. 1993
    ..mM glucosamine for 3 days exhibited a similar shift in the dose-response curve. The rightward shift in the dose-response curve is seen as early as 2 days after poration.(ABSTRACT TRUNCATED AT 250 WORDS)..
  11. doi Expression of GFAT1 and OGT in podocytes: transport of glucosamine and the implications for glucose uptake into these cells
    Dorota Rogacka
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland
    J Cell Physiol 225:577-84. 2010
    ..We studied the expression of GFAT1 and OGT and measured uptake of glucose and GlcN in cultured rat podocytes, the main cellular component of ..

Research Grants2

  1. New Therapeutic Targets in Pediatric Type 1 Diabetes
    Rubina Heptulla; Fiscal Year: 2007
    ..abstract_text> ..
  2. Pediatric Type 1 diabetes: Intervention Trials With Glucagon Suppressors
    Rubina A Heptulla; Fiscal Year: 2010
    ..Uses of exenatide and/or pramlintide provide us with potentially new tools to improve glycemic control in children and adolescents with T1 DM and thus reduce associated long-term microvascular complications of this debilitating disease. ..