Fez1

Summary

Gene Symbol: Fez1
Description: fasciculation and elongation protein zeta 1
Alias: fasciculation and elongation protein zeta-1, protein kinase C-binding protein Zeta1, zygin I, zygin-1
Species: rat

Top Publications

  1. ncbi Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth
    K Miyoshi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan
    Mol Psychiatry 8:685-94. 2003
  2. pmc Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells
    Mojgan H Naghavi
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Genes Dev 19:1105-15. 2005
  3. ncbi Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1245-58. 2006
  4. ncbi Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility
    Junko Ikuta
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Biochem Biophys Res Commun 353:127-32. 2007
  5. pmc Regulation of mitochondrial transport in neurons
    Mei Yao Lin
    Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B 215, 35 Convent Drive, Bethesda, MD 20892 3706, USA
    Exp Cell Res 334:35-44. 2015
  6. pmc Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein
    S Kuroda
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, 567 0047, Japan
    J Cell Biol 144:403-11. 1999
  7. ncbi Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain
    Akiko Honda
    Department of Brain Science, Graduate School of Medicine and Dentistry, Okayama University, Okayama 700 8558, Japan
    Brain Res Mol Brain Res 122:89-92. 2004
  8. ncbi Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis
    Fumihiko Okumura
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 279:53533-43. 2004
  9. ncbi Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation
    Tadaki Suzuki
    Laboratory of Molecular and Cellular Pathology, School of Medicine, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Sapporo, Japan
    J Biol Chem 280:24948-56. 2005
  10. ncbi Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells
    Toshitsugu Fujita
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Biochem Biophys Res Commun 361:605-10. 2007

Scientific Experts

  • Barbara K Lipska
  • S Kuroda
  • Toshitsugu Fujita
  • Junko Ikuta
  • Mei Yao Lin
  • Mojgan H Naghavi
  • Tadaki Suzuki
  • Juliane Haedicke
  • Jianghong He
  • Kenji Tatematsu
  • Katsuyuki Tanizawa
  • Toshihide Okajima
  • Hirofumi Sawa
  • Akiko Honda
  • Fumihiko Okumura
  • K Miyoshi
  • Zu Hang Sheng
  • Craig Brown
  • Maomin Sun
  • Ting Zhu
  • Jun Liu
  • ZhiJun Zhang
  • Chunlin Xia
  • AndrĂ©s D Maturana
  • Marie W Wooten
  • Sebastien Walchli
  • Andres Maturana
  • Juri Hamada
  • Kazuo Nagashima
  • Stephen P Goff
  • Yasuko Orba
  • Guangxia Gao
  • Shingo Semba
  • Theodora Hatziioannou
  • Yuki Okada
  • Shinya Tanaka
  • Shuichi Endo
  • Satoko Yamanouchi
  • Takumi Kamura
  • Keiichi I Nakayama
  • Shigetsugu Hatakeyama
  • Ko Miyoshi
  • Masaki Matsumoto
  • Taiichi Katayama
  • Manabu Taniguchi
  • Kousuke Baba
  • Yoshihisa Koyama
  • Masaya Tohyama
  • M Taniguchi
  • A Honda
  • K Oono
  • T Katayama
  • K Baba
  • M Tohyama
  • T Fujita

Detail Information

Publications12

  1. ncbi Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth
    K Miyoshi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan
    Mol Psychiatry 8:685-94. 2003
    ..Here, we demonstrated the existence of DISC1 protein and identified fasciculation and elongation protein zeta-1 (FEZ1) as an interacting partner of DISC1 by a yeast two-hybrid study...
  2. pmc Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells
    Mojgan H Naghavi
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Genes Dev 19:1105-15. 2005
    ..One of the candidate gene products, FEZ1 (fasciculation and elongation protein zeta-1), a protein kinase C (PKC)zeta-interacting protein homologous to the ..
  3. ncbi Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1245-58. 2006
    ..with binding partners involved in neuronal differentiation such as fasciculation and elongation protein zeta-1 (FEZ1), platelet-activating factor acetylhydrolase, isoform Ib, PAFAH1B1 or lissencephaly 1 protein (LIS1) and nuclear ..
  4. ncbi Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility
    Junko Ikuta
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Biochem Biophys Res Commun 353:127-32. 2007
    The fasciculation and elongation protein zeta-1 (FEZ1), a mammalian orthologue of Caenorhabditis elegans UNC-76 protein, is a 45-kDa protein with four coiled-coiled domains and efficiently promotes the neurite elongation in the rat ..
  5. pmc Regulation of mitochondrial transport in neurons
    Mei Yao Lin
    Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B 215, 35 Convent Drive, Bethesda, MD 20892 3706, USA
    Exp Cell Res 334:35-44. 2015
    ..The review focuses on microtubule (MT)-based mitochondrial trafficking and anchoring. Additional insight from different perspectives can be found in other in-depth reviews. ..
  6. pmc Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein
    S Kuroda
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, 567 0047, Japan
    J Cell Biol 144:403-11. 1999
    ..The protein designated FEZ1 (fasciculation and elongation protein zeta-1) consisting of 393 amino acid residues shows a high Asp/Glu content ..
  7. ncbi Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain
    Akiko Honda
    Department of Brain Science, Graduate School of Medicine and Dentistry, Okayama University, Okayama 700 8558, Japan
    Brain Res Mol Brain Res 122:89-92. 2004
    Fasciculation and elongation protein zeta-1 (FEZ1) is a mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth and fasciculation...
  8. ncbi Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis
    Fumihiko Okumura
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 279:53533-43. 2004
    ..With a yeast two-hybrid screen, we have now identified FEZ1 (fasciculation and elongation protein zeta 1) as a protein that interacts with E4B...
  9. ncbi Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation
    Tadaki Suzuki
    Laboratory of Molecular and Cellular Pathology, School of Medicine, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Sapporo, Japan
    J Biol Chem 280:24948-56. 2005
    ..We have now identified fasciculation and elongation protein zeta 1 (FEZ1) as a protein that interacted with JCV agnoprotein in a yeast two-hybrid screen of a ..
  10. ncbi Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells
    Toshitsugu Fujita
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Biochem Biophys Res Commun 361:605-10. 2007
    Fasciculation and elongation protein zeta-1 (FEZ1) promotes efficiently the neurite elongation of rat phaeochromocytoma PC12 cells. We here characterized FEZ1 in PC12 cells...
  11. doi Expression of fasciculation and elongation protein zeta-1 (FEZ1) in cultured rat neonatal astrocytes
    Jianghong He
    Cytoneurobiology Unit and Laboratory of Aging and Nervous Diseases, Medical College of Soochow University, 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, JS, 215123, People s Republic of China
    Mol Cell Biochem 325:159-67. 2009
    ..The fasciculation and elongation protein zeta-1 (FEZ1) gene was studied further because it has been suggested that it is not expressed by astrocytes...
  12. pmc The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection
    Juliane Haedicke
    Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 106:14040-5. 2009
    ..chemically mutagenized and selected for resistance to retroviral infection, we recently identified induction of rat FEZ1 (fasciculation and elongation protein zeta-1), a brain-specific protein, as the cause of this resistance...