Fabp2

Summary

Gene Symbol: Fabp2
Description: fatty acid binding protein 2
Alias: FABP, fatty acid-binding protein, intestinal, FABPI, I-FABP, fatty acid binding protein 1, fatty acid binding protein 2, intestinal, intestinal fatty acid binding protein, intestinal-type fatty acid-binding protein
Species: rat

Top Publications

  1. pmc Observation of sequential steps in the folding of intestinal fatty acid binding protein using a slow folding mutant and 19F NMR
    Hua Li
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:11993-8. 2007
  2. doi Time Scales of Conformational Gating in a Lipid-Binding Protein
    Shuji Kaieda
    Department of Biophysical Chemistry, Lund University, P O Box 124, SE 22100 Lund, Sweden
    J Phys Chem B 119:7957-67. 2015
  3. doi IFABP portal region insertion during membrane interaction depends on phospholipid composition
    Eduardo De Gerónimo
    Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, CCT La Plata CONICET, Facultad de Cs Médicas UNLP, Calle 60 y 120, 1900 La Plata, Argentina
    Biochim Biophys Acta 1841:141-50. 2014
  4. doi N-3 PUFAs attenuate ischemia/reperfusion induced intestinal barrier injury by activating I-FABP-PPARγ pathway
    Xinying Wang
    Research Institute of General Surgery, Jinling Hospital, 305 Zhongshan East Road, Nanjing 210002, China
    Clin Nutr 31:951-7. 2012
  5. ncbi Swapping core residues in homologous proteins swaps folding mechanism
    Paula M Dalessio
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Biochemistry 44:3082-90. 2005
  6. ncbi Thr54 allele of the FABP2 gene affects resting metabolic rate and visceral obesity
    Yasuto Takakura
    Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi Hirokoji, Kamikyo ku, Kyoto 602 8566, Japan
    Diabetes Res Clin Pract 67:36-42. 2005
  7. ncbi Fatty acid transfer from intestinal fatty acid binding protein to membranes: electrostatic and hydrophobic interactions
    Betina Corsico
    Instituto de Investigaciones Bioquimicas de La Plata, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, calles 60 y 120, 1900 La Plata, Argentina
    J Lipid Res 46:1765-72. 2005
  8. ncbi Genetic variation of the intestinal fatty acid-binding protein 2 gene in carotid atherosclerosis
    Pär Wanby
    County Hospital of Kalmar, Department of Internal Medicine, SE 391 85 Kalmar, Sweden
    Vasc Med 10:103-8. 2005
  9. ncbi Phenylalanine side chain behavior of the intestinal fatty acid-binding protein: the effect of urea on backbone and side chain stability
    Hua Li
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:38556-61. 2005
  10. ncbi The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes
    Luis H Canani
    Endocrine Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Diabetes 54:3326-30. 2005

Research Grants

Scientific Experts

  • Betina Corsico
  • Akinori Kogure
  • Yoshiji Yamada
  • A Georgopoulos
  • Dirk Bakowies
  • Cecilia Albala
  • Michael Lefevre
  • Pär Wanby
  • Francisco Perez
  • Hua Li
  • Shuji Kaieda
  • Eduardo De Gerónimo
  • Xinying Wang
  • Gisela Raquel Franchini
  • Lucrecia María Curto
  • Tony Velkov
  • Jose Maria Delfino
  • Gisela R Franchini
  • G R Franchini
  • Lisandro J Falomir-Lockhart
  • Carl Frieden
  • F Perez-Bravo
  • Karani S Vimaleswaran
  • Chang Hao Sun
  • Paula M Dalessio
  • Luis H Canani
  • Mario L Salguero
  • Yasuto Takakura
  • Koichi Setsuta
  • Cecilia N Arighi
  • Bertil Halle
  • Gregory R Steinberg
  • Lisandro Jorge Falomir Lockhart
  • Natalia Bottasso Arias
  • Luciana Rodriguez Sawicki
  • Marcelo Daniel Costabel
  • Fernando Zamarreño
  • Liya Pan
  • Jun Lu
  • D H Alpers
  • Ning Li
  • Jieshou Li
  • I J Ropson
  • M Carlsson
  • Maria L R Lim
  • James Horne
  • Christopher J H Porter
  • Jamie S Simpson
  • Lucrecia M Curto
  • Martin J Scanlon
  • Julio J Caramelo
  • Julio Javier Caramelo
  • J Storch
  • K Kim
  • H Sanchez
  • L Lera
  • J L Santos
  • Xiao rong Zhou
  • E Carrasco
  • M Fuentes
  • Venktesan Radha
  • Lisandro Laborde
  • Judith Storch
  • Peter C Kahn
  • Dan Zhao
  • Viswanathan Mohan
  • B Angel
  • Serena G L Choo
  • Arturo Santos
  • Ira J Ropson
  • Toshikazu Yoshikawa
  • Keiji Yoshioka
  • Sonia Roman
  • Ana Luiza Maia
  • Jorge E Segura-Ortega
  • Daniel P K Ng
  • Andrzej S Krolewski
  • Gustavo B Nabinger
  • Clarissa Capp
  • Katia Santos
  • Jorge L Gross
  • Toshihide Yoshida
  • Joshua A Boyer
  • Arturo Panduro
  • Ricardo E Leon
  • Hitoshi Toda
  • Israel Roisemberg
  • Tsunekazu Umekawa
  • Jessica L McGettigan
  • Daisy Crispim

Detail Information

Publications42

  1. pmc Observation of sequential steps in the folding of intestinal fatty acid binding protein using a slow folding mutant and 19F NMR
    Hua Li
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:11993-8. 2007
    The rat intestinal fatty acid binding protein (IFABP) primarily comprises two beta-sheet structures surrounding a large internal cavity. The urea denatured WT protein folds within seconds after dilution to nondenaturing conditions...
  2. doi Time Scales of Conformational Gating in a Lipid-Binding Protein
    Shuji Kaieda
    Department of Biophysical Chemistry, Lund University, P O Box 124, SE 22100 Lund, Sweden
    J Phys Chem B 119:7957-67. 2015
    ..The remaining 90% (apo) or 70% (holo) of cavity waters exchange among internal hydration sites on a time scale of ∼1 ns but exhibit substantial orientational order, particularly in the holo form...
  3. doi IFABP portal region insertion during membrane interaction depends on phospholipid composition
    Eduardo De Gerónimo
    Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, CCT La Plata CONICET, Facultad de Cs Médicas UNLP, Calle 60 y 120, 1900 La Plata, Argentina
    Biochim Biophys Acta 1841:141-50. 2014
    ..These results may be relevant to understand the mechanism of ligand transfer and the specificity responsible for the unique functions of each member of the FABP family.
  4. doi N-3 PUFAs attenuate ischemia/reperfusion induced intestinal barrier injury by activating I-FABP-PPARγ pathway
    Xinying Wang
    Research Institute of General Surgery, Jinling Hospital, 305 Zhongshan East Road, Nanjing 210002, China
    Clin Nutr 31:951-7. 2012
    This study was designed to investigate whether n-3 PUFAs attenuate ischemia/reperfusion (I/R) induced intestinal barrier injury by activating I-FABP-PPARγ pathway.
  5. ncbi Swapping core residues in homologous proteins swaps folding mechanism
    Paula M Dalessio
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Biochemistry 44:3082-90. 2005
    Rat intestinal fatty acid binding protein (IFABP) displays an intermediate with little if any secondary structure during unfolding, while the structurally homologous rat ileal lipid binding protein (ILBP) displays an intermediate during ..
  6. ncbi Thr54 allele of the FABP2 gene affects resting metabolic rate and visceral obesity
    Yasuto Takakura
    Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi Hirokoji, Kamikyo ku, Kyoto 602 8566, Japan
    Diabetes Res Clin Pract 67:36-42. 2005
    We investigated the relationship between Ala54Thr variant allele of the fatty acid-binding protein 2 (FABP2) gene (Ala54Thr) and development of obesity in Japanese obese women...
  7. ncbi Fatty acid transfer from intestinal fatty acid binding protein to membranes: electrostatic and hydrophobic interactions
    Betina Corsico
    Instituto de Investigaciones Bioquimicas de La Plata, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, calles 60 y 120, 1900 La Plata, Argentina
    J Lipid Res 46:1765-72. 2005
    b>Intestinal fatty acid binding protein (IFABP) is thought to participate in the intracellular transport of fatty acids (FAs)...
  8. ncbi Genetic variation of the intestinal fatty acid-binding protein 2 gene in carotid atherosclerosis
    Pär Wanby
    County Hospital of Kalmar, Department of Internal Medicine, SE 391 85 Kalmar, Sweden
    Vasc Med 10:103-8. 2005
    The alanine (A) to threonine (T) substitution at codon 54 of the intestinal fatty acid-binding protein 2 (FABP2) has been associated with dyslipidaemia and other characteristics of the metabolic syndrome, which in turn is a risk factor ..
  9. ncbi Phenylalanine side chain behavior of the intestinal fatty acid-binding protein: the effect of urea on backbone and side chain stability
    Hua Li
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:38556-61. 2005
    ..E., and Frieden, C. (2001) Biochemistry 40, 732-742) and suggest that the side chains show more stability than the backbone prior to global unfolding of the protein...
  10. ncbi The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes
    Luis H Canani
    Endocrine Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Diabetes 54:3326-30. 2005
    The intestinal fatty-acid binding protein-2 (FABP2) gene codes a protein responsible for the absorption of long-chain fatty acids...
  11. ncbi The role of FABP2 gene polymorphism in alcoholic cirrhosis
    Mario L Salguero
    Department of Molecular Biology, Civil Hospital of Guadalajara Fray Antonio Alcalde, Universitary Center for the Health Sciences, University of Guadalajara, P O Box 2 500, Guadalajara, 44280 Jalisco, Mexico Institute of Molecular Biology in Medicine, Universitary Center for the Health Sciences, University of Guadalajara, Sierra Mojada 950, Guadalajara, 44340 Jalisco, Mexico
    Hepatol Res 33:306-12. 2005
    ..The intestinal fatty acid binding protein (IFABP) is the main transporter of dietary fatty acids into the enterocyte and has a genetic ..
  12. ncbi Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypes
    Michael Lefevre
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Metabolism 54:1652-8. 2005
    ..In addition, a polymorphism at codon 54 (Ala54Thr) in the fatty acid-binding protein 2 (FABP2) gene has been suggested to modify an interaction between dietary fat and insulin sensitivity...
  13. ncbi Protein-membrane interaction and fatty acid transfer from intestinal fatty acid-binding protein to membranes. Support for a multistep process
    Lisandro J Falomir-Lockhart
    Instituto de Investigaciones Bioquimicas de La Plata, CONICET UNLP, Facultad de Ciencias Medicas, calles 60 y 120, 1900 La Plata, Argentina
    J Biol Chem 281:13979-89. 2006
    ..Protein-membrane interactions were also found to be enhanced by the presence of ligand, suggesting different collisional complex structures for holo- and apo-IFABP...
  14. ncbi Thr54 allele carriers of the Ala54Thr variant of FABP2 gene have associations with metabolic syndrome and hypertriglyceridemia in urban South Indians
    Karani S Vimaleswaran
    Department of Molecular Genetics Madras Diabetes Research Foundation, Gopalapuram, Chennai, 600 086, India
    Metabolism 55:1222-6. 2006
    ..02-1.51; P = .03), whereas for those carrying the Thr54Thr genotype, it was 1.812 (95% CI, 1.28-2.57; P = .001). Carriers of the Thr54 allele have associations with MS and hypertriglyceridemia in this urban South Indian population...
  15. ncbi [Effect of conjugated linoleic acid on the gene expression of the fatty acid binding proteins in resistant rat]
    Chang Hao Sun
    School of Public Health, Harbin Medical University, Harbin 150086, China
    Wei Sheng Yan Jiu 35:297-9. 2006
    ..To study the effect of conjugated linoleic acid on gene expression of fatty acid binding proteins (ap2) in white obesity tissue of rats with insulin resistance, and explore the mechanism of resisting diabetes by CLA...
  16. ncbi Lack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chile
    F Perez-Bravo
    Department of Public Nutrition Genetic Epidemiology Unit, Institute of Nutrition and Food Technology INTA, University of Chile, Santiago, P O Box 138 11, Chile
    Acta Diabetol 43:93-8. 2006
    The aim of this study was to assess the frequency of fatty acid binding protein 2 (FABP2) Ala54Thr genetic polymorphism and to evaluate its association with obesity and insulin resistance in Chilean aboriginal populations...
  17. pmc The integrity of the alpha-helical domain of intestinal fatty acid binding protein is essential for the collision-mediated transfer of fatty acids to phospholipid membranes
    G R Franchini
    Instituto de Investigaciones Bioquimicas de La Plata, CONICET UNLP, Facultad de Ciencias Medicas, calles 60 y 120, 1900 La Plata, Argentina
    Biochim Biophys Acta 1781:192-9. 2008
    Intestinal FABP (IFABP) and liver FABP (LFABP), homologous proteins expressed at high levels in intestinal absorptive cells, employ markedly different mechanisms of fatty acid transfer to acceptor model membranes...
  18. doi Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein
    Tony Velkov
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, 3052, Victoria, Australia
    Mol Cell Biochem 326:87-95. 2009
    b>Intestinal fatty acid binding protein (I-FABP) is present at high levels in the absorptive cells of the intestine (enterocytes) where it plays a role in the intracellular solubilization of fatty acids (FA)...
  19. pmc Delta98Delta, a minimalist model of antiparallel beta-sheet proteins based on intestinal fatty acid binding protein
    Lucrecia María Curto
    Department of Biological Chemistry and Institute of Biochemistry and Biophysics IQUIFIB, School of Pharmacy and Biochemistry, University of Buenos Aires, C1113AAD Buenos Aires, Argentina
    Protein Sci 18:735-46. 2009
    ..From the opposite standpoint provided by the redesign of natural motifs, we believe that the intestinal fatty acid binding protein (IFABP) framework allows room for intervention, giving rise to abridged forms from which lessons ..
  20. pmc Dissection of a beta-barrel motif leads to a functional dimer: the case of the intestinal fatty acid binding protein
    Gisela R Franchini
    Department of Biological Chemistry and Institute of Biochemistry and Biophysics IQUIFIB, School of Pharmacy and Biochemistry, University of Buenos Aires, C1113AAD, Buenos Aires, Argentina
    Protein Sci 18:2592-602. 2009
    ..In this regard, the framework provided by intestinal fatty acid binding protein (IFABP) was successfully chosen to explore the consequences on structure and function of the ..
  21. pmc Properties and crystal structure of a beta-barrel folding mutant
    I J Ropson
    Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Biophys J 78:1551-60. 2000
    A mutant of a beta-barrel protein, rat intestinal fatty acid binding protein, was predicted to be more stable than the wild-type protein due to a novel hydrogen bond...
  22. ncbi Crystal structure of rat intestinal fatty-acid-binding protein. Refinement and analysis of the Escherichia coli-derived protein with bound palmitate
    J C Sacchettini
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110
    J Mol Biol 208:327-39. 1989
    Rat intestinal fatty-acid-binding protein (I-FABP) is a small (15,124 Mr) cytoplasmic polypeptide that binds long-chain fatty acids in a non-covalent fashion...
  23. pmc Refined apoprotein structure of rat intestinal fatty acid binding protein produced in Escherichia coli
    J C Sacchettini
    Department of Biochemistry, Washington University School of Medicine, Saint Louis, MO 63110
    Proc Natl Acad Sci U S A 86:7736-40. 1989
    Rat intestinal fatty acid binding protein (I-FABP) is a member of a family of cytoplasmic hydrophobic ligand-binding proteins...
  24. ncbi The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships
    D A Sweetser
    Department of Biological Chemistry, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 262:16060-71. 1987
    b>Intestinal fatty acid binding protein (I-FABP) is believed to participate in the uptake, intracellular metabolism, and/or transport of long chain fatty acids within enterocytes. The 15...
  25. ncbi Analyzing the structures, functions and evolution of two abundant gastrointestinal fatty acid binding proteins with recombinant DNA and computational techniques
    J I Gordon
    Chem Phys Lipids 38:137-58. 1985
    ..The primary translation product of intestinal FABP mRNA contains 132 residues (Mr = 15 124). Liver FABP mRNA encodes a 127 amino acid polypeptide (Mr = 14 273)...
  26. pmc Cloning of a cDNA encoding rat intestinal fatty acid binding protein
    D H Alpers
    Proc Natl Acad Sci U S A 81:313-7. 1984
    b>Intestinal fatty acid binding protein mRNA is one of the most abundant mRNA species in the rat small intestinal epithelium...
  27. pmc An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance
    L J Baier
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona 85016
    J Clin Invest 95:1281-7. 1995
    The intestinal fatty acid binding protein locus (FABP2) was investigated as a possible genetic factor in determining insulin action in the Pima Indian population...
  28. ncbi Discrete backbone disorder in the nuclear magnetic resonance structure of apo intestinal fatty acid-binding protein: implications for the mechanism of ligand entry
    M E Hodsdon
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 36:1450-60. 1997
    ..structure of the unliganded form of Escherichia coli-derived rat intestinal fatty acid-binding protein (I-FABP) has been determined using triple-resonance three-dimensional nuclear magnetic resonance (3D NMR) methods...
  29. ncbi Evidence for a role of the gut hormone PYY in the regulation of intestinal fatty acid-binding protein transcripts in differentiated subpopulations of intestinal epithelial cell hybrids
    G Hallden
    Department of Nutritional Sciences, University of California, Berkeley, California 94720 3104, USA
    J Biol Chem 272:12591-600. 1997
    ..Intestinal fatty acid-binding protein (I-FABP) binds FFA and may be involved in their cytosolic trafficking...
  30. pmc Turn scanning by site-directed mutagenesis: application to the protein folding problem using the intestinal fatty acid binding protein
    K Kim
    Department of Food Science, Woosong University, Daejeon, Korea
    Protein Sci 7:1821-8. 1998
    We have systematically mutated residues located in turns between beta-strands of the intestinal fatty acid binding protein (IFABP), and a glycine in a half turn, to valine and have examined the stability, refolding rate constants and ..
  31. ncbi Intestinal fatty acid binding protein may favor differential apical fatty acid binding in the intestine
    D H Alpers
    Division of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110 1010, USA
    Biochim Biophys Acta 1483:352-62. 2000
    ..More fatty acid was bound to L-FABP than to I-FABPs (28% vs. 6% of cytosolic radioactivity), no matter on which side the fatty acid was added...
  32. ncbi Refinement of the structure of recombinant rat intestinal fatty acid-binding apoprotein at 1.2-A resolution
    G Scapin
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 267:4253-69. 1992
    ..structure of the 131-residue rat intestinal fatty acid-binding protein, without bound ligand (apoI-FABP), has been refined with x-ray diffraction data to a nominal resolution of 1.19 A...
  33. ncbi The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke
    M Carlsson
    Department of Endocrinology, Malmo University Hospital, Sweden
    J Clin Endocrinol Metab 85:2801-4. 2000
    To test the hypothesis that the A/T polymorphism of the fatty acid-binding protein 2 gene (FABP2) is associated with impaired lipid metabolism and cardiovascular disease, we compared clinical characteristics and a parental history of ..
  34. ncbi Codon-54 polymorphism of the fatty acid-binding protein 2 gene is associated with elevation of fasting and postprandial triglyceride in type 2 diabetes
    A Georgopoulos
    Minneapolis Veterans Affairs Medical Center, University of Minnesota, 55417, USA
    J Clin Endocrinol Metab 85:3155-60. 2000
    ..Our results are consistent with the hypothesis that, in type 2 diabetes, increased intestinal input of triglyceride can lead to elevated fasting and postprandial plasma triglycerides...
  35. ncbi Chronic leptin administration decreases fatty acid uptake and fatty acid transporters in rat skeletal muscle
    Gregory R Steinberg
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 277:8854-60. 2002
    ..88, p < 0.01) and plasma membrane FABPpm protein (r = 0.94, p < 0.01). These studies provide the first evidence that protein-mediated long chain fatty acid transport is subject to long term regulation by leptin...
  36. ncbi Simulations of apo and holo-fatty acid binding protein: structure and dynamics of protein, ligand and internal water
    Dirk Bakowies
    Laboratory of Physical Chemistry, Swiss Federal Institute of Technology, Zurich, 8093, Switzerland
    J Mol Biol 315:713-36. 2002
    Two molecular dynamics simulations of 5 ns each have been carried out for rat intestinal fatty acid binding protein, in apo-form and with bound palmitate...
  37. ncbi Temperature-induced conformational switch in intestinal fatty acid binding protein (IFABP) revealing an alternative mode for ligand binding
    Cecilia N Arighi
    Department of Biological Chemistry and Institute of Biochemistry and Biophysics IQUIFIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Biochemistry 42:7539-51. 2003
    ..These results highlight the idea of an enhanced flexibility exhibited by IFABP that bears importance on its transport function, supporting the role of a dynamic entry portal region for the fatty acid ligand...
  38. ncbi Intestinal FABP2 A54T polymorphism: association with insulin resistance and obesity in women
    Cecilia Albala
    Department of Public Nutrition, Genetic Epidemiology Unit, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    Obes Res 12:340-5. 2004
    To assess the association between the Ala54Thr genetic polymorphism of the fatty acid-binding protein 2 (FABP2) gene with insulin resistance and obesity.
  39. ncbi The alpha-helical domain of liver fatty acid binding protein is responsible for the diffusion-mediated transfer of fatty acids to phospholipid membranes
    Betina Corsico
    Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, CONICET UNLP, Facultad de Ciencias Medicas, calles 60 y 120, 1900 La Plata, Argentina
    Biochemistry 43:3600-7. 2004
    b>Intestinal fatty acid binding protein (IFABP) and liver FABP (LFABP), homologous proteins expressed at high levels in intestinal absorptive cells, employ markedly different mechanisms for the transfer of fatty acids (FAs) to acceptor ..
  40. ncbi Genetic risk for coronary artery disease in individuals with or without type 2 diabetes
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Mol Genet Metab 81:282-90. 2004
    ..Genotyping of these polymorphisms may prove informative for assessment of the genetic risk for CAD in the absence or presence of type 2 diabetes...
  41. ncbi Ongoing myocardial damage in chronic heart failure is related to activated tumor necrosis factor and Fas/Fas ligand system
    Koichi Setsuta
    Division of Cardiology, Department of Medicine, Tokyo Metropolitan Komagome Hospital, Japan
    Circ J 68:747-50. 2004
    Elevated concentrations of cardiac troponin T and heart-type fatty acid-binding protein (H-FABP) identify patients with chronic heart failure (CHF) and ongoing myocardial damage (OMD) who are at increased risk for future cardiac events...

Research Grants1

  1. Diet, genetics, and CVD risk factor response in Blacks
    Michael Lefevre; Fiscal Year: 2006
    ..This information will guide the design of future dietary and lifestyle interventions to combat CVD. ..