F2rl1

Summary

Gene Symbol: F2rl1
Description: F2R like trypsin receptor 1
Alias: Par-2, Par2, proteinase-activated receptor 2, Proteinase-activated receptor-2, G protein-coupled receptor 11, coagulation factor II (thrombin) receptor-like 1, coagulation factor II receptor-like 1, thrombin receptor-like 1
Species: rat

Top Publications

  1. ncbi Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia
    Wolfgang Knecht
    Molecular Pharmacology and Lead Generation, AstraZeneca Research and Development, Mölndal 431 83, Sweden
    J Biol Chem 282:26089-100. 2007
  2. pmc Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain
    Yi Dai
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo, Japan
    J Clin Invest 117:1979-87. 2007
  3. ncbi Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats
    Anne Marie Coelho
    Neuro Gastroenterology and Nutrition Unit, INRA, Toulouse Cedex, France
    Gastroenterology 122:1035-47. 2002
  4. ncbi Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2
    Grant R Stenton
    Pulmonary Research Group, Department of Medicine, Astra Zeneca Canada Inc, Glaxo Heritage Asthma Research Laboratory, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Pharmacol Exp Ther 302:466-74. 2002
  5. doi Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2
    Zhi Jiang Huang
    Department of Neurobiology, Parker University Research Institute, Dallas, TX 75229, USA
    Pain 153:1426-37. 2012
  6. doi Effects of chronic in-vivo treatments with protease-activated receptor 2 agonist on endothelium function and blood pressures in mice
    Keon H Hughes
    Cardiovascular Research Group, Division of Biomedical Sciences, Memorial University, St John s, NL A1B 3V6, Canada
    Can J Physiol Pharmacol 91:295-305. 2013
  7. doi Acute PAR2 activation reduces GABAergic inhibition in the spinal dorsal horn
    Zhangxiang Huang
    Department of Anesthesiology, Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China
    Brain Res 1425:20-6. 2011
  8. pmc Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue
    M Saifeddine
    Department of Pharmacology and Therapeutics, University of Calgary, Faculty of Medicine, AB Canada
    Br J Pharmacol 118:521-30. 1996
  9. pmc Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling
    Daniel P Poole
    Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia
    J Biol Chem 288:5790-802. 2013
  10. pmc Proteinase-activated receptor-1 and -2 induce the release of chemokine GRO/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain
    Yingfei Wang
    Institut fur Neurobiochemie, Medizinische Fakultat, Otto von Guericke Universitat Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Biochem J 401:65-78. 2007

Scientific Experts

  • A Kawabata
  • Baojin Hua
  • Yanju Bao
  • Subrina Jesmin
  • Satomi Kagota
  • Zs Helyes
  • John S Smeda
  • William R Ferrell
  • M Dux
  • Qihai Gu
  • Navneet Sharma
  • Ke shu Xu
  • Rithwik Ramachandran
  • Seigo Hidaka
  • Amrita Ahluwalia
  • Q T Dinh
  • Hashem N Alshurafa
  • Luciana Morla
  • Rink Jan Lohman
  • Georg Reiser
  • Morley D Hollenberg
  • Wan Namkung
  • Shenglan Wang
  • Yi Dai
  • Jonathan H Foley
  • Yingfei Wang
  • Weibo Luo
  • Kana Maruyama
  • Zhihui Zhu
  • John J McGuire
  • Makoto Oikawa
  • Joan Antoni Fernández-Blanco
  • M Bucci
  • Majedeline Belghiti
  • Daniel P Poole
  • Keon H Hughes
  • Xiaoliang Gan
  • Young Hwan Kim
  • F A Russell
  • Wolfgang Liedtke
  • Elena Sokolova
  • De Zhao Liu
  • Grazyna Kwapiszewska
  • Zhi Jiang Huang
  • S K Suckow
  • Xuemei Wang
  • Jinju Li
  • Ming Yan Chen
  • Wei Zhang
  • Elise Duchesne
  • Norimasa Yoshida
  • Zhangxiang Huang
  • Martine Imbert-Teboul
  • Gilles Crambert
  • Alain Doucet
  • Hyung Ju Cho
  • Silvia Amadesi
  • Nigel W Bunnett
  • Zhi Jie Lu
  • Rodger Loutzenhiser
  • Yan Luo
  • Deepak K Bhatt
  • Murasaki Aman
  • Koichi Noguchi
  • Hiroki Yamanaka
  • Kimiko Kobayashi
  • Takayuki Matsumoto
  • Ryu Iida
  • Xiao Hong Tong
  • Ai Horie
  • Yoshinori Matsuwaki
  • Yu Gui
  • Shelby K Suckow
  • Tiffany K Ricks
  • Ram Sharma
  • Wolfgang Knecht
  • Heung Man Lee
  • Rong Jiang
  • Min Goo Lee
  • Kyung Hwan Kim
  • Alice Rickard
  • Nathalie Vergnolle
  • M D Hollenberg
  • Edward M Conway
  • T Rohatgi
  • Rolf Stricker
  • Rong yu Li
  • Gregor Zündorf
  • Noriko Yoshikawa
  • Kazumasa Shinozuka

Detail Information

Publications81

  1. ncbi Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia
    Wolfgang Knecht
    Molecular Pharmacology and Lead Generation, AstraZeneca Research and Development, Mölndal 431 83, Sweden
    J Biol Chem 282:26089-100. 2007
    ..Thus, trypsin IV and p23 are inhibitor-resistant trypsins that can cleave and activate PARs, causing PAR(1)- and PAR(2)-dependent inflammation and PAR(2)-dependent hyperalgesia...
  2. pmc Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain
    Yi Dai
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo, Japan
    J Clin Invest 117:1979-87. 2007
    Proinflammatory agents trypsin and mast cell tryptase cleave and activate PAR2, which is expressed on sensory nerves to cause neurogenic inflammation...
  3. ncbi Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats
    Anne Marie Coelho
    Neuro Gastroenterology and Nutrition Unit, INRA, Toulouse Cedex, France
    Gastroenterology 122:1035-47. 2002
    ..The aim of this study was to determine whether colonic administration of PAR-2 agonists affects visceral sensitivity to rectal distention in conscious rats...
  4. ncbi Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2
    Grant R Stenton
    Pulmonary Research Group, Department of Medicine, Astra Zeneca Canada Inc, Glaxo Heritage Asthma Research Laboratory, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Pharmacol Exp Ther 302:466-74. 2002
    ..The responsiveness of mast cells to PAR-AP via a non-PAR-1/non-PAR-2 mechanism complicates the interpretation of in vivo studies using these peptides...
  5. doi Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2
    Zhi Jiang Huang
    Department of Neurobiology, Parker University Research Institute, Dallas, TX 75229, USA
    Pain 153:1426-37. 2012
    ..Here, we report that protease-activated receptor 2 (PAR2) activation after CCD or dissociation mediates the increase of cAMP activity and protein kinase A (PKA) and cAMP-..
  6. doi Effects of chronic in-vivo treatments with protease-activated receptor 2 agonist on endothelium function and blood pressures in mice
    Keon H Hughes
    Cardiovascular Research Group, Division of Biomedical Sciences, Memorial University, St John s, NL A1B 3V6, Canada
    Can J Physiol Pharmacol 91:295-305. 2013
    Short-term treatments with protease-activated receptor 2-activating peptides (PAR2-AP) induce endothelium-dependent vasodilation and decrease blood pressure...
  7. doi Acute PAR2 activation reduces GABAergic inhibition in the spinal dorsal horn
    Zhangxiang Huang
    Department of Anesthesiology, Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China
    Brain Res 1425:20-6. 2011
    ..of spinal dorsal horn GABAergic neurotransmission to elucidate the role of protease-activated receptor-2 (PAR2). Initially, we confirmed that PAR2 agonist SL-NH(2) applied intrathecally produced mechanical hyperalgesia...
  8. pmc Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue
    M Saifeddine
    Department of Pharmacology and Therapeutics, University of Calgary, Faculty of Medicine, AB Canada
    Br J Pharmacol 118:521-30. 1996
    ....
  9. pmc Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling
    Daniel P Poole
    Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia
    J Biol Chem 288:5790-802. 2013
    ..Thus, PAR(2) activation generates a signal that induces sustained activation of TRPV4, which requires a key tyrosine residue (TRPV4-Tyr-110). This mechanism partly mediates the proinflammatory actions of PAR(2)...
  10. pmc Proteinase-activated receptor-1 and -2 induce the release of chemokine GRO/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain
    Yingfei Wang
    Institut fur Neurobiochemie, Medizinische Fakultat, Otto von Guericke Universitat Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Biochem J 401:65-78. 2007
    ..This provides new functional insights into PAR/JNK signalling and the protective actions of PARs in brain...
  11. doi Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14
    Rithwik Ramachandran
    Department of Physiology and Pharmacology, University of Calgary, Faculty of Medicine, AB, Canada
    Biol Chem 393:421-7. 2012
    ..Further, we analysed processing by KLK8 vs. KLK14 of synthetic human and rat PAR2-derived sequences representing the cleavage-activation domain of PAR2...
  12. doi PAR-2-mediated control of barrier function and motility differs between early and late phases of postinfectious gut dysfunction in the rat
    Joan Antoni Fernández-Blanco
    Department of Cell Biology, Physiology and Immunology, Veterinary School, Universitat Autonoma de Barcelona, Barcelona, Spain
    Am J Physiol Gastrointest Liver Physiol 304:G390-400. 2013
    ..A lack of a ketotifen effect suggests no interplay between MCs and PAR-2-mediated motility and ion transport alterations. These observations question the role of MC mediators in PAR-2-modulating postinfectious gut dysfunction...
  13. doi Effects of protease-activated receptors (PARs) on intracellular calcium dynamics of acinar cells in rat lacrimal glands
    Makoto Oikawa
    Department of Anatomy Cell Biology, Iwate Medical University, 2 1 1 Nishitokuda, Yahaba, Iwate, 028 3694, Japan
    Histochem Cell Biol 140:463-76. 2013
    ..Only PAR2 mRNA was detected in acinar cells of lacrimal glands...
  14. doi Involvement of protease-activated receptor 2 in nociceptive behavior in a rat model of bone cancer
    Yanju Bao
    Department of Oncology, Guang anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng, Beijing, 100053, China
    J Mol Neurosci 52:566-76. 2014
    ..Protease-activated receptor 2 (PAR2), a receptor for inflammatory proteases, has been implicated in nociceptive signaling under both normal and ..
  15. pmc PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain
    Yanju Bao
    Department of Oncology, Guang anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, 100053 Beijing, China
    Mol Pain 10:28. 2014
    ..While several studies demonstrated the critical role of proteinase-activated receptor (PAR2) in the pathogenesis of several types of inflammatory or neuropathic pain, the involvement of spinal PAR2 and the ..
  16. doi The intracellular carboxyl tail of the PAR-2 receptor controls intracellular signaling and cell death
    Zhihui Zhu
    Institut fur Neurobiochemie, Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Leipziger Straße 44, 39120, Magdeburg, Germany
    Cell Tissue Res 359:817-27. 2015
    ..In summary, the PAR-2 carboxyl tail was found to control the receptor localization, internalization, intracellular Ca(2+) responses and signaling to ERK and AKT. The latter can be considered to be important for cell death control. ..
  17. doi Enhanced Nitric Oxide Synthase Activation via Protease-Activated Receptor 2 Is Involved in the Preserved Vasodilation in Aortas from Metabolic Syndrome Rats
    Kana Maruyama
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    J Vasc Res 52:232-43. 2015
    Endothelium-dependent vasodilation via protease-activated receptor 2 (PAR2) is preserved in mesenteric arteries from SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP...
  18. doi Cross Talk Pathways Between Coagulation and Inflammation
    Jonathan H Foley
    From the Department of Haematology, UCL Cancer Institute, University College London, London, United Kingdom J H F Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free NHS Trust, London, United Kingdom J H F and Centre for Blood Research, Department of Medicine, University of British Columbia, Vancouver, Canada E M C
    Circ Res 118:1392-408. 2016
    ..In this review, we highlight some of the key molecular interactions, some of which are already showing promise as therapeutic targets for inflammatory and thrombotic disorders. ..
  19. ncbi [Relationship of protease-activated receptor-2 and mast cell in the rat model of small intestinal mucosal damage by short-term administration of non-steroidal anti-inflammatory drug]
    Ming Yan Chen
    Department of Gastroenterology, First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou 310061, China
    Zhonghua Yi Xue Za Zhi 91:1502-5. 2011
    ..To identify the expression and significance of protease-activated receptor-2 (PAR-2) and mast cell (MC) in the rat model of small intestinal mucosal damage by a short-term administration of diclofenac...
  20. doi Increase of L-type Ca2+ current by protease-activated receptor 2 activation contributes to augmentation of spontaneous uterine contractility in pregnant rats
    Young Hwan Kim
    Brain Korea 21 Project for Medical Science, Department of Physiology, Yonsei University College of Medicine, Seoul 120 752, Republic of Korea
    Biochem Biophys Res Commun 418:167-72. 2012
    ....
  21. pmc Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)
    Rithwik Ramachandran
    Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 286:24638-48. 2011
    ..Our data illustrate a new mode of PAR regulation that involves biased PAR(2) signaling by neutrophil elastase and a disarming/silencing effect of cathepsin-G and proteinase-3...
  22. pmc Mast cell tryptase stimulates myoblast proliferation; a mechanism relying on protease-activated receptor-2 and cyclooxygenase-2
    Elise Duchesne
    CHUQ Research Center and Faculty of Medicine, Laval University, 2705 Boul, Laurier, Quebec, Quebec G1V 4G2, Canada
    BMC Musculoskelet Disord 12:235. 2011
    ..The aim of this study was to evaluate whether tryptase can stimulate myoblast proliferation and determine the downstream cascade...
  23. doi Antagonism of protease-activated receptor 2 protects against experimental colitis
    Rink Jan Lohman
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    J Pharmacol Exp Ther 340:256-65. 2012
    ..Here, we investigate whether masking their common target, protease-activated receptor 2 (PAR2), is an effective therapeutic strategy for treating acute and chronic experimental colitis in rats...
  24. pmc Implantation serine proteinase 1 exhibits mixed substrate specificity that silences signaling via proteinase-activated receptors
    Navneet Sharma
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada
    PLoS ONE 6:e27888. 2011
    ..We observed that ISP1 silenced enzyme-triggered PAR signaling by receptor-disarming. This PAR-disarming action of ISP1 may be important for embryo development and implantation...
  25. pmc Lesioning of TRPV1 expressing primary afferent neurons prevents PAR-2 induced motility, but not mechanical hypersensitivity in the rat colon
    S K Suckow
    Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL, USA
    Neurogastroenterol Motil 24:e125-35. 2012
    b>Proteinase activated receptor 2 (PAR-2) is expressed by many neurons in the colon, including primary afferent neurons that co-express transient receptor potential vanilloid 1 (TRPV1)...
  26. doi Mast-cell-releasing tryptase triggers acute lung injury induced by small intestinal ischemia-reperfusion by activating PAR-2 in rats
    Xiaoliang Gan
    Department of Anesthesiology, The Third Affiliated Hospital, Sun Yat Sen University, 600 Tianhe Road, Guangzhou, China
    Inflammation 35:1144-53. 2012
    ..Tryptase released from mast cells mediates ALI induced by intestinal ischemia-reperfusion by activating PAR-2 to produce IL-8...
  27. doi PAR-2 inhibition reverses experimental pulmonary hypertension
    Grazyna Kwapiszewska
    Department of Internal Medicine, University of Giessen Lung Centre, Germany
    Circ Res 110:1179-91. 2012
    ..Accumulating evidence suggests that mast cell mediators play a role in the pathogenesis of PH...
  28. doi Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain
    Shenglan Wang
    State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100088, China
    Eur J Neurosci 36:2293-301. 2012
    ....
  29. pmc Activation of PAR(2) receptors sensitizes primary afferents and causes leukocyte rolling and adherence in the rat knee joint
    F A Russell
    Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada
    Br J Pharmacol 167:1665-78. 2012
    ..The PAR(2) receptors are involved in chronic arthritis by mechanisms that are as yet unclear. Here, we examined PAR(2) activation in the rat knee joint...
  30. pmc Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR(2) ) is involved in vascular function
    M Bucci
    Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, Napoli, Italy
    Br J Pharmacol 168:411-20. 2013
    ..The aim of this study was to evaluate the possible cross-talk between PAR(2) and TLR4 in vessels in physiological condition and how it varies following stimulation of TLR4 by using in vivo and ex vivo models...
  31. ncbi [Effects of cromolyn sodium on intestinal ischemia-reperfusion injury by inhibiting PAR-2 expression in rats]
    De Zhao Liu
    Department of Anesthesiology, Third Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, China
    Zhonghua Yi Xue Za Zhi 92:2597-600. 2012
    ..To explore the effects of cromolyn sodium (CS) on intestinal ischemia-reperfusion (IIR) and its relationship with mast cell activation and protease-activated receptor 2 (PAR-2) expression...
  32. pmc Potentiation of the transient receptor potential vanilloid 1 channel contributes to pruritogenesis in a rat model of liver disease
    Majedeline Belghiti
    Centro de Investigacion Principe Felipe, 46012 Valencia, Spain
    J Biol Chem 288:9675-85. 2013
    ..contribution of histaminergic/serotonergic receptors, but significant activation of protein-activated receptor 2 (PAR2) receptors, prostaglandin PGE2 formation, and potentiation of transient receptor potential vanilloid 1 (TRPV1) ..
  33. doi Expression of protease-activated receptor (PAR)-2, but not other PARs, is regulated by inflammatory cytokines in rat astrocytes
    Elena Sokolova
    Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Institut fur Neurobiochemie, Leipziger Straße 44, D 39120 Magdeburg, Germany
    Neurochem Int 60:276-85. 2012
    ..These findings provide new information about the regulation of expression of PAR subtypes in brain cells. This is of importance for targeting PARs, especially PAR-2, for the treatment of CNS disorders...
  34. pmc Renal proteinase-activated receptor 2, a new actor in the control of blood pressure and plasma potassium level
    Luciana Morla
    Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Universite Paris Descartes, INSERM, UMRS872 and Centre National de la Recherche Scientifique, ERL7226, 75270 Paris Cedex 06, France
    J Biol Chem 288:10124-31. 2013
    Proteinase-activated receptor 2 (PAR2) is a G protein-coupled membrane receptor that is activated upon cleavage of its extracellular N-terminal domain by trypsin and related proteases...
  35. doi Proteinase-activated receptor 2 mediates thermal hyperalgesia and is upregulated in a rat model of chronic pancreatitis
    Wei Zhang
    Division of Field Medicine, Department of Internal Medicine, Changhai Hospital, Second Military Medical University, Shanghai, PR China
    Pancreas 40:300-7. 2011
    The mechanism of pain in chronic pancreatitis (CP) has yet to be explored. Proteinase-activated receptor 2 (PAR2) plays a pronociceptive role in visceral pain...
  36. doi Acute PAR2 activation reduces alpha, beta-MeATP sensitive currents in rat dorsal root ganglion neurons
    Zhi Jie Lu
    Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
    Neuroreport 21:227-32. 2010
    It has been reported that proteinase-activated receptor 2 (PAR2) receptor activation enhances the animal's pain response and PAR2 coexpresses with P2X3 in dorsal root ganglion neurons...
  37. ncbi [The effect of protease-activated receptor2 on rat apoptotic cardiomyocytes underwent ischemia reperfusion injury]
    Xiao Hong Tong
    Department of Cardiology, First College of Clinical Medical Science, China Three Gorges University, Yichang Central People s Hospital, Yichang 443003, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:832-6. 2009
    ..To investigate the effect of protease-activated receptor 2 (PAR-2) on rat apoptotic cardiomyocytes underwent ischemia reperfusion (I/R) injury...
  38. doi House dust mite extract activates apical Cl(-) channels through protease-activated receptor 2 in human airway epithelia
    Hyung Ju Cho
    Department of Otorhinolaryngology, Hallym University College of Medicine, Seoul, South Korea
    J Cell Biochem 109:1254-63. 2010
    ..Our results suggest a role for PAR-2 in mucociliary clearance and fluid hypersecretion of airway mucosa in response to air-borne allergens such as HDM...
  39. doi Long-term downregulation of protease-activated receptor-2 expression in distal colon in rats following bacillary dysentery
    Yan Luo
    Department of Physiology, Shandong University School of Medicine, Jinan, 250012, PR China
    Regul Pept 163:49-56. 2010
    ..This might be the reason of the low sensitivity of the colon circular muscle strips to the PAR-2-AP-induced relaxation following intragastric administration of S.flexneri...
  40. doi Upregulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortas
    Murasaki Aman
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Vasc Res 47:494-506. 2010
    ..The effects of oxidative stress on the vascular responsiveness to the agonists of proteinase-activated receptors (PARs) were investigated...
  41. doi Activation of PAR-2 elicits NO-dependent and CGRP-independent dilation of the dural artery
    Deepak K Bhatt
    Department of Neurology, Glostrup Research Institute, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Glostrup, Denmark
    Headache 50:1017-30. 2010
    ..The goal of this study was to determine the vascular effects of protease-activated receptor-2 (PAR-2) activation in the rat cranial vasculature...
  42. pmc TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles
    Jinju Li
    Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    Environ Health Perspect 119:784-93. 2011
    ..Human respiratory epithelia function in airway mucociliary clearance and barrier function and have recently been implicated in sensory functions...
  43. doi Proinflammatory role of protease-activated receptor-2 in intestinal ischemia/reperfusion injury in rats
    Norimasa Yoshida
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Mol Med Rep 4:81-6. 2011
    ..Pre-treatment with anti-rat PCS antibody significantly inhibited the increases in these parameters. These results suggest that PAR-2 plays an important role in the pathogenesis of ischemia/reperfusion-induced intestinal injury...
  44. pmc Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils
    Yoshinori Matsuwaki
    Department of Medicine and Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 183:6708-16. 2009
    ..Thus, fungal aspartate protease and eosinophil PAR-2 appear critical for the eosinophils' innate immune response to certain fungi, suggesting a novel mechanism for pathologic inflammation in asthma and for host-pathogen interaction...
  45. ncbi Bidirectional regulation of renal hemodynamics by activation of PAR1 and PAR2 in isolated perfused rat kidney
    Yu Gui
    Canadian Institutes of Health Group on the Regulation of Vascular Contractility, Smooth Muscle Research Group, Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Renal Physiol 285:F95-104. 2003
    ..In the present study, we evaluated the impact of PAR activation on renal hemodynamics using PAR1- and PAR2-activating peptides (TFLLR-NH2 and SLIGRL-NH2) and proteinases (thrombin and trypsin) as PAR agonists in the ..
  46. ncbi [Changes of mast cells and protease activated receptor-2 in experimental rat liver fibrosis]
    Ke shu Xu
    Department of Gastroenterology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Gan Zang Bing Za Zhi 14:753-6. 2006
    ..To explore the quantity of mast cells and the role of protease activated receptor-2 (PAR-2) in experimental rat liver fibrosis...
  47. pmc Hypersensitivity of pulmonary chemosensitive neurons induced by activation of protease-activated receptor-2 in rats
    Qihai Gu
    Department of Physiology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536 0298, USA
    J Physiol 574:867-76. 2006
    This study was carried out to determine the effect of protease-activated receptor-2 (PAR2) activation on the pulmonary chemoreflex responses and on the sensitivity of isolated rat vagal pulmonary chemosensitive neurons...
  48. ncbi Protease-activated receptor 2 expression in trigeminal neurons innervating the rat nasal mucosa
    Q Thai Dinh
    Department of Internal Medicine, Charite School of Medicine, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Neuropeptides 39:461-6. 2005
    Protease-activated receptor 2 (PAR2) is activated by trypsin and mast cell tryptase to induce widespread inflammation by unknown mechanisms...
  49. ncbi Protease-activated receptor stimulation activates a Ca2+-independent phospholipase A2 in bladder microvascular endothelial cells
    Alice Rickard
    Dept of Pathology, Saint Louis Univ School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Am J Physiol Renal Physiol 288:F714-21. 2005
    ....
  50. ncbi Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Life Sci 75:2689-702. 2004
    ..These findings demonstrate that endothelial PAR-1 and PAR-2, upon activation, dilate the gastric artery via NO and prostanoid formation and also EDHF mechanisms including gap junctions, which would enhance GMBF...
  51. ncbi Redundant signaling mechanisms contribute to the vasodilatory response of the afferent arteriole to proteinase-activated receptor-2
    Xuemei Wang
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, 3330 Hospital Dr N W, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Renal Physiol 288:F65-75. 2005
    ....
  52. pmc A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation
    Hashem N Alshurafa
    Department of Medicine, University of Alberta, Edmonton, AB, Canada, T6G 2S2
    BMC Pharmacol 4:12. 2004
    ..Recent evidence also suggests that MC-induced inflammation can be mediated through PAR. Therefore, we hypothesized that specific PAR-2 agonist peptides (PAR-2ap) induce protease release from PMC...
  53. ncbi Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis
    Wan Namkung
    Department of Pharmacology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 134 Sinchon dong, Seoul 120 752, Korea
    Gastroenterology 126:1844-59. 2004
    ..In this study, we investigated the roles of pancreatic and circulatory protease-activated receptor 2 in the pathogenesis of acute pancreatitis by using in vitro and in vivo model systems...
  54. ncbi Protease-activated receptor subtype expression in developing eye and adult retina of the rat after optic nerve crush
    T Rohatgi
    Institut fur Neurobiochemie, Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Magdeburg, Germany
    J Neurosci Res 73:246-54. 2003
    ..PAR upregulation because of nerve crush in the mild trauma model could act as an effector of early cell death. Eventual return of receptor mRNA to basal levels is consistent with neuroprotection...
  55. ncbi Chymase increases glomerular albumin permeability via protease-activated receptor-2
    Ram Sharma
    Renal Research Laboratory, Kansas City VA Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA
    Mol Cell Biochem 297:161-9. 2007
    ..MCC may also play a role in renal scarring. We propose that inhibiting MCC activity or blocking the activation of PAR-2 may provide new targets for therapy in renal diseases...
  56. pmc Essential role for proteinase-activated receptor-2 in arthritis
    William R Ferrell
    Centre for Rheumatic Diseases, Royal Infirmary, University of Glasgow, Glasgow, United Kingdom
    J Clin Invest 111:35-41. 2003
    ....
  57. ncbi Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion
    Atsufumi Kawabata
    Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, 577 8502, Higashi Osaka, Japan
    Life Sci 71:2435-46. 2002
    ....
  58. ncbi Role of N-methyl-D-aspartate receptors and the nitric oxide pathway in nociception/hyperalgesia elicited by protease-activated receptor-2 activation in mice and rats
    Atsufumi Kawabata
    Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka 577 8502, Japan
    Neurosci Lett 329:349-53. 2002
    ..Our study thus provides a novel mouse model for PAR-2-mediated nociception, and suggests that NMDA receptors are involved in PAR-2-triggered nociception and hyperalgesia, while NO contributes only to the latter...
  59. ncbi Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors
    M Riek-Burchardt
    Project Group Neuropharmacology, Leibniz Institute for Neurobiology, POB 1860, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Neurosci Lett 329:181-4. 2002
    ..Thus, control of the balance between the expression of prothrombin and PN-1 may reflect an important mechanism that underlies postischemic thrombin effects...
  60. ncbi Protease-activated receptor-2 activation improves efficiency of experimental ischemic preconditioning
    Claudio Napoli
    Department of Medicine, Federico II University of Naples, Italy
    Am J Physiol Heart Circ Physiol 282:H2004-10. 2002
    ..These data support the concept that PAR-2-dependent cell trafficking may regulate signaling responses to cardiac ischemia and inflammation...
  61. ncbi PAR-2 elicits afferent arteriolar vasodilation by NO-dependent and NO-independent actions
    Greg Trottier
    Smooth Muscle Research Group, Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Renal Physiol 282:F891-7. 2002
    ..These findings indicate that PAR-2 is expressed in the afferent arteriole and that its activation elicits afferent arteriolar vasodilation by NO-dependent and NO-independent mechanisms...
  62. ncbi Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia/reperfusion injury: involvement of lipoxygenase products, VR1 receptors, and C-fibers
    Peter G McLean
    Centre for Clinical Pharmacology, Department of Medicine, University College London, UK
    Circ Res 90:465-72. 2002
    ..Therefore, we investigated the effects of PAR2 activation on coronary tone in isolated perfused rat hearts and elucidated the mechanisms of any observed effects...
  63. ncbi Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors
    Marianna D A Gaca
    Liver Research Group, University Division of Infection, Inflammation and Repair, Southampton General Hospital, SO16 6YD, Southampton, UK
    J Hepatol 36:362-9. 2002
    ..We have examined if rat stellate cells express these receptors and if receptor agonists influence stellate cell activation...
  64. doi Involvement of capsaicin-sensitive afferent nerves in the proteinase-activated receptor 2-mediated vasodilatation in the rat dura mater
    M Dux
    Department of Physiology, University of Szeged, Szeged, Hungary
    Neuroscience 161:887-94. 2009
    ..The results indicate that the PAR-2-mediated activation and sensitization of meningeal capsaicin-sensitive C-fiber nociceptors may be significantly implicated in the pathophysiology of headaches...
  65. pmc Regulation of acid signaling in rat pulmonary sensory neurons by protease-activated receptor-2
    Qihai Gu
    Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Am J Physiol Lung Cell Mol Physiol 298:L454-61. 2010
    ....
  66. doi Protease-activated receptor 2 and bradykinin-mediated vasodilation in the cerebral arteries of stroke-prone rats
    John S Smeda
    Division of Biomedical Sciences, Memorial University, St John s, Newfoundland, Canada
    Peptides 31:227-37. 2010
    ..Despite the presence of vascular injury, edema, inflammation and the loss of endothelium-dependent bradykinin vasodilation we found no evidence that PAR(2) expression or vascular function was altered in MCA after stroke...
  67. pmc Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization
    Tiffany K Ricks
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7365, USA
    J Biol Chem 284:34444-57. 2009
    Protease-activated receptor 2 (PAR2) is a G protein-coupled receptor irreversibly activated by extracellular proteases...
  68. pmc NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs) during inflammation induced visceral hypersensitivity
    Shelby K Suckow
    Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Mol Pain 5:54. 2009
    ..afferent neurons (CANs), co-localize with the NR1 and NR2D subunits of the NMDA receptor as well as with the PAR2 receptor...
  69. doi Gabexate mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury
    Seigo Hidaka
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, Yufu City, Oita, Japan
    J Surg Res 165:142-50. 2011
    ..This indicates that GM can inhibit lung injury induced by LPS in rats. GM is a candidate for use in novel strategies to prevent or minimize lung injury in sepsis...
  70. doi Involvement of transient receptor potential vanilloid 1 receptors in protease-activated receptor-2-induced joint inflammation and nociception
    Zs Helyes
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7624 Pecs, Szigeti u 12, Hungary
    Eur J Pain 14:351-8. 2010
    ..Although intraplantar PAR-2 activation-induced oedema is also TRPV1 receptor-mediated, primary mechanical hyperalgesia, impaired weight distribution and IL-1beta production are independent of this channel...
  71. doi Mechanisms underlying enhanced vasorelaxant response to protease-activated receptor 2-activating peptide in type 2 diabetic Goto-Kakizaki rat mesenteric artery
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo, Japan
    Peptides 30:1729-34. 2009
    Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor that is proteolytically activated by certain endogenous proteases, such as trypsin, tryptase, and factor Xa...
  72. doi A regulatory role for protease-activated receptor-2 in motivational learning in rats
    Rink Jan Lohman
    Department of Pharmacology, University of Melbourne, Victoria, Australia
    Neurobiol Learn Mem 92:301-9. 2009
    ..Given our previous findings that trypsin and its receptor, protease-activated receptor-2 (PAR2), are both highly expressed in pyramidal neurons of the hippocampus and that activation of PAR2 attenuates '..
  73. ncbi Proinflammatory cytokines suppress the expression level of protease-activated receptor-2 through the induction of iNOS in rat colon
    Ai Horie
    Laboratory of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University
    J Vet Med Sci 71:1609-15. 2009
    ..These results suggest that suppression of PAR-2 expression under inflammatory conditions is at least partially induced by NO produced in the colonic muscularis externa by proinflammatory cytokines...
  74. doi Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure
    Subrina Jesmin
    Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Shock 32:626-32. 2009
    ..These results show that PAR-2 plays a key role in the inflammatory and coagulation process of LPS-induced renal failure; however, PAR-2 inhibition alone does not affect improvement in the renal function...
  75. doi Expression of proteinase-activated receptor-2 in the intervertebral disc
    Ryu Iida
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan
    Spine (Phila Pa 1976) 34:470-8. 2009
    ..Immunohistochemical and biochemical analyses of proteinase-activated receptor-2 (PAR-2) in rat and human intervertebral discs (IVDs)...
  76. doi PAR2 exerts local protection against acute pancreatitis via modulation of MAP kinase and MAP kinase phosphatase signaling
    Wan Namkung
    Dept of Pharmacology, Yonsei Univ College of Medicine, Seoul 120 752, Korea
    Am J Physiol Gastrointest Liver Physiol 295:G886-94. 2008
    During acute pancreatitis, protease-activated receptor 2 (PAR2) can be activated by interstitially released trypsin...
  77. pmc Proteinase-activated receptor 2 stimulates Na,K-ATPase and sodium reabsorption in native kidney epithelium
    Luciana Morla
    Universite Pierre et Marie Curie, Univ Paris 06, UMR 7134, 75005 Paris
    J Biol Chem 283:28020-8. 2008
    Proteinase-activated receptors 2 (PAR2) are expressed in kidney, but their function is mostly unknown...
  78. ncbi Up-regulation of protease-activated receptor 2 in allergic rhinitis
    Heung Man Lee
    Department of Otorhinolaryngology Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea
    Ann Otol Rhinol Laryngol 116:554-8. 2007
    ..We compared the patterns of PAR-2 messenger RNA (mRNA) and protein expression in the nasal mucosa of subjects with and without allergic rhinitis...
  79. ncbi PAR-2 activation at the time of reperfusion salvages myocardium via an ERK1/2 pathway in in vivo rat hearts
    Rong Jiang
    Department of Cardiothoracic Surgery, Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center of Crawford Long Hospital, Emory University School of Medicine, Atlanta, GA, USA
    Am J Physiol Heart Circ Physiol 293:H2845-52. 2007
    ..LY + PAR-2 AP, 38 +/- 3%; P > 0.05). Therefore, PAR-2 activation is cardioprotective in the in vivo rat heart ischemia-reperfusion model, and this protection involves the ERK1/2 pathway and PKC...
  80. ncbi p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking
    Weibo Luo
    Institut fur Neurobiochemie, Medizinische Fakultat, Otto von Guericke Universitat Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Biol Chem 282:30246-55. 2007
    ..These findings identify a new function of p24A as a regulator of signal-dependent trafficking that regulates the life cycle of PAR-2, Thus, we reveal a new molecular mechanism underlying resensitization of PAR-2...
  81. ncbi Differential expression, time course and distribution of four PARs in rats with endotoxin-induced acute lung injury
    Subrina Jesmin
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060, Japan
    Inflammation 30:14-27. 2007
    ..The differential expression patterns (over a time course) and distribution of PAR isoforms suggests a distinct role for each isoform in the pathogenesis of LPS-induced ALI...