Esr2

Summary

Gene Symbol: Esr2
Description: estrogen receptor 2
Alias: ER-beta, ERbeta, Erb2, estrogen receptor beta, estrogen receptor 2 (ER beta), estrogen receptor 2 beta, nuclear receptor subfamily 3 group A member 2
Species: rat

Top Publications

  1. ncbi Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues
    D N Petersen
    Department of Molecular Sciences and Osteoporosis Group, Pfizer Central Research, Groton, Connecticut 06340, USA
    Endocrinology 139:1082-92. 1998
  2. pmc Cloning of a novel receptor expressed in rat prostate and ovary
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Proc Natl Acad Sci U S A 93:5925-30. 1996
  3. ncbi Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    G G Kuiper
    Center for Biotechnology, Karolinska Institute, Huddinge, Sweden
    Endocrinology 138:863-70. 1997
  4. ncbi A novel isoform of rat estrogen receptor beta with 18 amino acid insertion in the ligand binding domain as a putative dominant negative regular of estrogen action
    K Maruyama
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    Biochem Biophys Res Commun 246:142-7. 1998
  5. pmc Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human
    S Ogawa
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Nucleic Acids Res 26:3505-12. 1998
  6. pmc Estrogen receptors activate atrial natriuretic peptide in the rat heart
    M Jankowski
    Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 98:11765-70. 2001
  7. ncbi Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta
    Yan Zhu
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Science 295:505-8. 2002
  8. pmc Disruption of estrogen receptor beta gene impairs spatial learning in female mice
    Emilie F Rissman
    Department of Biology and Internal Medicine, University of Virginia, Charlottesville, VA 22903, USA
    Proc Natl Acad Sci U S A 99:3996-4001. 2002
  9. ncbi Regulation of estrogen receptor (ER) isoform messenger RNA expression by different ER ligands in female rat pituitary
    M Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain
    Biol Reprod 70:671-8. 2004
  10. ncbi Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women
    S Lilly Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Res 63:7624-9. 2003

Research Grants

  1. ESTROGEN COMPOUNDS, COGNITION & DEMENTIA IN OLDER WOMEN
    Kristine Yaffe; Fiscal Year: 2002
  2. ESTROGEN IMPRINTING OF PROSTATE GLAND VIA METHYLATON
    Gail Prins; Fiscal Year: 2005
  3. Metabolic Syndrome and Cognitive Impairment
    Kristine Yaffe; Fiscal Year: 2005
  4. ECM Regulation by Estrogen in ARMD
    Sharon Elliot; Fiscal Year: 2006
  5. Sex Hormones, Related Polymorphisms & Cognitive Decline
    Kristine Yaffe; Fiscal Year: 2006
  6. Development Estrogenization of the Rat Prostate Gland
    Gail S Prins; Fiscal Year: 2010
  7. Estrogen Modulates Dopamine Signaling
    JILL SHARIFI; Fiscal Year: 2005
  8. Female Reproductive Organs and Their Innervation.
    RAYMOND PAPKA; Fiscal Year: 2006

Detail Information

Publications142 found, 100 shown here

  1. ncbi Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues
    D N Petersen
    Department of Molecular Sciences and Osteoporosis Group, Pfizer Central Research, Groton, Connecticut 06340, USA
    Endocrinology 139:1082-92. 1998
    The effects of estrogen and estrogen agonists can be mediated by estrogen receptor alpha (ER alpha) and estrogen receptor beta (ER beta)...
  2. pmc Cloning of a novel receptor expressed in rat prostate and ovary
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Proc Natl Acad Sci U S A 93:5925-30. 1996
    ..We conclude that clone 29 cDNA encodes a novel rat ER, which we suggest be named rat ERbeta to distinguish it from the previously cloned ER (ERalpha) from rat uterus.
  3. ncbi Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    G G Kuiper
    Center for Biotechnology, Karolinska Institute, Huddinge, Sweden
    Endocrinology 138:863-70. 1997
    The rat estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal ligand binding domain and in the N-terminal transactivation domain...
  4. ncbi A novel isoform of rat estrogen receptor beta with 18 amino acid insertion in the ligand binding domain as a putative dominant negative regular of estrogen action
    K Maruyama
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    Biochem Biophys Res Commun 246:142-7. 1998
    A novel isoform of rat estrogen receptor (ER) beta, ER beta 2, which is a putative alternative splicing product of the reported ER beta (ER beta 1) has been identified...
  5. pmc Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human
    S Ogawa
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Nucleic Acids Res 26:3505-12. 1998
    ..Biochemical analysis reveals that the average dissociation constants ( K d) of ERalpha and ERbeta for 17beta-estradiol (E2) are 0.2 and 0.6 nM respectively, but ERbetacx has no ligand binding ability...
  6. pmc Estrogen receptors activate atrial natriuretic peptide in the rat heart
    M Jankowski
    Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 98:11765-70. 2001
    ..study, semiquantitative reverse transcription-PCR analysis showed that estrogen receptor alpha (ERalpha) and beta (ERbeta) mRNAs are developmentally regulated in the rat heart...
  7. ncbi Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta
    Yan Zhu
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Science 295:505-8. 2002
    ..We show that vascular smooth muscle cells and blood vessels from estrogen receptor beta (ERbeta)-deficient mice exhibit multiple functional abnormalities...
  8. pmc Disruption of estrogen receptor beta gene impairs spatial learning in female mice
    Emilie F Rissman
    Department of Biology and Internal Medicine, University of Virginia, Charlottesville, VA 22903, USA
    Proc Natl Acad Sci U S A 99:3996-4001. 2002
    ..evidence, to our knowledge, that estradiol (E(2)) affects learning and memory via the newly discovered estrogen receptor beta (ERbeta)...
  9. ncbi Regulation of estrogen receptor (ER) isoform messenger RNA expression by different ER ligands in female rat pituitary
    M Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain
    Biol Reprod 70:671-8. 2004
    ..agonistic or antagonistic properties at the ER, to modulate the expression of the transcripts encoding ERalpha and ERbeta isoforms, as well as those for the truncated ERalpha product (TERP), and the variant ERbeta2, in pituitaries from ..
  10. ncbi Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women
    S Lilly Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Res 63:7624-9. 2003
    ..DNA samples from the Shanghai Breast Cancer Study, we tested the hypothesis that sequence variants of the estrogen receptor beta gene (ESR2) may be associated with increased risk for breast cancer, particularly among women who have a ..
  11. pmc Mitochondrial localization of estrogen receptor beta
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Proc Natl Acad Sci U S A 101:4130-5. 2004
    ..To date, two ERs have been identified: ERalpha and ERbeta. ERalpha plays major role in the estrogen-mediated genomic actions in both reproductive and nonreproductive tissue,..
  12. ncbi Estrogen receptor beta expression and apoptosis of spermatocytes of mice overexpressing a rat androgen-binding protein transgene
    David M Selva
    Grup de Recerca en Endocrinologia Molecular, Hospital Universitari Vall d Hebron, Pg Vall d Hebron, 119 129, 08035 Barcelona, Spain
    Biol Reprod 71:1461-8. 2004
    ..In view of the recent localization of estrogen receptor beta (ERbeta) in primary spermatocytes and data suggesting the ability of ERbeta to repress cellular ..
  13. ncbi Novel actions of estrogen receptor-beta on anxiety-related behaviors
    Trent D Lund
    Department of Biomedical Science, Colorado State University, Anatomy W103, 1617 Campus Delivery, Fort Collins, Colorado 80523 1670, USA
    Endocrinology 146:797-807. 2005
    ..response to estrogens may be mediated by the existence of two distinct estrogen receptor (ER) systems, ERalpha and ERbeta. In brain, ERalpha plays a critical role in regulating reproductive neuroendocrine function, whereas ERbeta may be ..
  14. ncbi Estrogen receptor (ER)beta isoforms rather than ERalpha regulate corticotropin-releasing hormone promoter activity through an alternate pathway
    William J Schouler Miller
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908 0904, USA
    J Neurosci 24:10628-35. 2004
    ..of the corticotropin-releasing hormone (CRH) promoter via either of its receptors: estrogen receptor (ER)alpha or ERbeta. Immunocytochemistry revealed that a subset (12%) of medial parvocellular CRH neurons in the rat hypothalamus ..
  15. ncbi Estrogen receptor genotypes and haplotypes associated with breast cancer risk
    Bert Gold
    Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, USA
    Cancer Res 64:8891-900. 2004
    ..receptor gene (PGR), 17 SNPs in estrogen receptor 1 gene (ESR1), and 8 SNPs in the estrogen receptor 2 gene (ESR2)...
  16. ncbi Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis
    P Fytili
    Department of Orthopedics, Medical School, University of Thessaly, Universit Hospital of Larissa, Larissa, Greece
    Clin Genet 68:268-77. 2005
    ..002 and 0.001). An association between c.1092+3607(CA)(13-27) and c.172(CAG)(8-34) repeat polymorphisms of the ER-beta and AR genes and knee OA was found in individuals of Greek descent...
  17. ncbi Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer
    Paula Maguire
    Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Breast Cancer Res Treat 94:145-52. 2005
    ..through binding to the estrogen receptors, estrogen receptor alpha (ESR1) and the more recently discovered estrogen receptor beta (ESR2)...
  18. pmc Androgens' effects to enhance learning may be mediated in part through actions at estrogen receptor-beta in the hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building Rm 1058, 1400 Washington Avenue, Albany, NY 12222, USA
    Neurobiol Learn Mem 87:78-85. 2007
    ..We found that intrahippocampal administration of AS-ODNs for ERbeta, but not ERalpha, significantly decreased learning and memory of 3alpha-diol replaced rats...
  19. pmc Estrogen receptor beta-deficient female mice develop a bladder phenotype resembling human interstitial cystitis
    Otabek Imamov
    Department of Biosciences and Nutrition, Karolinska Institute, Novum, SE 141 86 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:9806-9. 2007
    ..has been implicated in the etiology of this disease, but the role of the two estrogen receptors (ER), ERalpha and ERbeta, has not been investigated...
  20. ncbi Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer
    A Tsezou
    Laboratory of Cytogenetics and Molecular Genetics, Medical School, University of Thessalia, University Hospital of Larissa, Larissa, Greece
    Breast 17:159-66. 2008
    ..To determine the possible contribution of genetic variation in the ESR1 (ER-alpha), ESR2 (ER-beta) and AR genes in breast cancer risk the -1174(TA)(7-27), c. 1092+3607(CA)(10-26) and c...
  21. pmc Estradiol regulates corticotropin-releasing hormone gene (crh) expression in a rapid and phasic manner that parallels estrogen receptor-alpha and -beta recruitment to a 3',5'-cyclic adenosine 5'-monophosphate regulatory region of the proximal crh promoter
    Avin S Lalmansingh
    Neuroscience Graduate Program, University of Virginia School of Medicine, P O Box 800733, Charlottesville, Virginia 22908 0733, USA
    Endocrinology 149:346-57. 2008
    ..b>ERbeta associated with CBP and increased acetylated histone 4...
  22. doi Neonatal exposure to endocrine active compounds or an ERbeta agonist increases adult anxiety and aggression in gonadally intact male rats
    Heather B Patisaul
    Department of Zoology, North Carolina State University, 127 David Clark Labs, Raleigh, NC 27695, USA
    Horm Behav 53:580-8. 2008
    ..Recent evidence suggests that these effects may be mediated through the beta form of the estrogen receptor (ERbeta)...
  23. doi Polymorphisms in the promoter region of ESR2 gene and breast cancer susceptibility
    Oliver Treeck
    Department of Obstetrics and Gynecology, University of Regensburg, Landshuter Strasse 65, Regensburg, Germany
    J Steroid Biochem Mol Biol 114:207-11. 2009
    ..Our data suggest that a SNP in the promoter region of ESR2 gene might be able to affect breast cancer risk. These results further support the emerging hypothesis that ERbeta is an important factor in breast cancer development.
  24. pmc Estrogen and aging affect the synaptic distribution of estrogen receptor β-immunoreactivity in the CA1 region of female rat hippocampus
    Elizabeth M Waters
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Brain Res 1379:86-97. 2011
    ..This suggests that synaptic ERβ may be a more responsive target to E, particularly in aged females...
  25. doi Acute restraint stress increases intrahypothalamic oestradiol concentrations in conjunction with increased hypothalamic oestrogen receptor β and aromatase mRNA expression in female rats
    J Liu
    Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Chinese Academy of Sciences, Hefei, Anhui, China
    J Neuroendocrinol 23:435-43. 2011
    ..The rising hypothalamic oestradiol concentration together with increased ERβ gene expression indicates a positive feedback of hypothalamic oestradiol signalling during acute stress in rats...
  26. pmc An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Cell 145:584-95. 2011
    ..These findings provide evidence for an ADIOL/ERβ/CtBP-transrepression pathway that regulates inflammatory responses in microglia and can be targeted by selective ERβ modulators...
  27. doi Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory
    Feng Liu
    Wyeth Research, Discovery Neuroscience, 865 Ridge Road, Monmouth Junction, New Jersey 08852, USA
    Nat Neurosci 11:334-43. 2008
    ..molecular mechanisms underlying these effects and the roles of the estrogen receptors alpha (ERalpha) and beta (ERbeta) remain unclear...
  28. ncbi Gonadotropins decrease estrogen receptor-beta messenger ribonucleic acid stability in rat granulosa cells
    C Guo
    Department of Physiology, University of Kentucky, Lexington 40536 0084, USA
    Endocrinology 142:2230-7. 2001
    We have previously shown that the preovulatory LH surge down-regulates estrogen receptor-beta (ERbeta) messenger RNA (mRNA) levels selectively in the granulosa cells of preovulatory follicles...
  29. ncbi Quantitative analysis of estrogen receptor-alpha and -beta messenger RNA expression in normal and malignant thyroid tissues by real-time polymerase chain reaction
    C Egawa
    Department of Surgical Oncology, Osaka University Medical School, Osaka, Japan
    Oncology 61:293-8. 2001
    ..We have conducted a quantitative analysis of estrogen receptor-alpha (ER-alpha) and -beta (ER-beta) mRNA expression in normal thyroid and tumor tissues...
  30. ncbi The novel 5'-untranslated first exon, exon 0H, of the rat estrogen receptor beta gene
    Hideki Iwamoto
    Department of Obstetrics and Gynecology, Yamanashi Medical University, Tamaho, Nakakoma, Yamanashi, Japan
    Endocr Res 29:157-68. 2003
    ..However, a few reports are available concerning tissue-specific regulation of the expression of the estrogen receptor beta (ERbeta) gene...
  31. ncbi Regulation of estrogen receptor-beta expression in the female rat hypothalamus: differential effects of dexamethasone and estradiol
    Shotaro Suzuki
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Endocrinology 145:3658-70. 2004
    ..To date, the hormonal regulatory profile of the ERbeta gene in the rat central nervous system has not been closely elucidated...
  32. ncbi Quantitative analysis of estrogen receptor proteins in rat ovary
    Hideki Sakaguchi
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 1 1 Yanagido, Gifu City 501 1194, Japan
    J Steroid Biochem Mol Biol 94:83-91. 2005
    The mRNAs of estrogen receptor beta (ERbeta), and its splice variant, ERbeta2, are abundant in granulosa cells in the ovary...
  33. ncbi Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells
    Griselda Vallejo
    Instituto de Biologia y Medicina Experimental IByME CONICET, Obligado 2490, 1428 Buenos Aires, Argentina
    Mol Endocrinol 19:3023-37. 2005
    ..uterine stromal cells to a short treatment with progestins requires active progesterone receptor (PR) and estrogen receptor beta (ERbeta) as well as a rapid and transient activation of Erk1-2 and Akt signaling...
  34. ncbi Genetic polymorphisms of estrogen receptors in patients with premature coronary artery disease
    Antonio de Padua Mansur
    Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Arch Med Res 36:511-7. 2005
    ..Both receptors exist in the arterial wall, but the extent of their distribution in arterial layers is unknown. Allelic variants of the gene encoding ESR1 and ESR2 may alter their expression and function, resulting in genetic variability.
  35. pmc Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease
    Lisa Gallicchio
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    BMC Cancer 6:173. 2006
    ..study was conducted to examine the role of genetic polymorphisms in three estrogen metabolizing enzymes (COMT, CYP1A1, CYP1B1) and the two estrogen receptors (ESR1, ESR2) in the progression of benign breast disease (BBD) to breast cancer.
  36. ncbi Sex-specific densities of estrogen receptors alpha and beta in the subnuclei of the nucleus tractus solitarius, hypoglossal nucleus and dorsal vagal motor nucleus weanling rats
    Evelyn H Schlenker
    Division of Basic Biomedical Sciences, University of South Dakota, Vermillion, SD 57069, USA
    Brain Res 1123:89-100. 2006
    ..and immunohistochemistry in weanling male and female rats to quantitate areas and densities of ER alpha and ER beta-positive neurons within medullary regions associated with cardiopulmonary regulation including the hypoglossal ..
  37. ncbi Effect of ovariectomy on renal estrogen receptor-alpha and estrogen receptor-beta in young salt-sensitive and -resistant rats
    Maria Eugenia Davila Esqueda
    Department of Anesthesiology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Hypertension 50:768-72. 2007
    This study evaluated the effect of ovariectomy on renal estrogen receptor (ER)-alpha and ERbeta expression in young female Dahl salt-sensitive and salt-resistant rats...
  38. pmc Estrogen receptor beta protects against acoustic trauma in mice
    Inna Meltser
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Clin Invest 118:1563-70. 2008
    ..We found a ligand-dependent protective role for ERbeta in the auditory system by investigating mice deficient in ERalpha (ERKO mice), ERbeta (BERKO mice), and aromatase (..
  39. doi Estrogen receptor beta mediates acute myocardial protection following ischemia
    Meijing Wang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Surgery 144:233-8. 2008
    ..It has been suggested that ER beta plays a part in decreasing myocardial inflammation following hemorrhage...
  40. pmc Developmental and hormone-induced epigenetic changes to estrogen and progesterone receptor genes in brain are dynamic across the life span
    Jaclyn M Schwarz
    Program in Neuroscience, Department of Physiology, University of Maryland, Baltimore, 655 West Baltimore Street, 5 015, Baltimore, Maryland 21201, USA
    Endocrinology 151:4871-81. 2010
    ....
  41. pmc Rapid signaling actions of environmental estrogens in developing granule cell neurons are mediated by estrogen receptor ß
    Hoa H Le
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0575, USA
    Endocrinology 151:5689-99. 2010
    ....
  42. pmc Estrogen receptor ß activity modulates synaptic signaling and structure
    Deepak P Srivastava
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 30:13454-60. 2010
    ..These results implicate ERβ signaling in controlling dendritic spine morphology, in part via a PAK/ERK1/2-dependent pathway, and provide mechanistic insight into the rapid cellular effects of estrogen on brain function...
  43. doi Estrogen receptor-β signaling modulates epithelial barrier function
    Mirjam Looijer-van Langen
    Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Physiol Gastrointest Liver Physiol 300:G621-6. 2011
    ..This study suggests a potential role for ERβ signaling in the modulation of epithelial permeability and demonstrates reduced ERβ mRNA in animal models of colitis and colon of patients with inflammatory bowel disease...
  44. doi Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: A drill-hole defect model
    Yi Xin He
    Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Bone 48:1388-400. 2011
    ..To establish a drill-hole defect model in osteoporotic mouse femur by comparing temporal cortical bone healing pattern between OVX-induced osteoporotic bone and sham-operated bone...
  45. doi Attenuation of atherogenesis via the anti-inflammatory effects of the selective estrogen receptor beta modulator 8β-VE2
    Jiangfeng Sun
    Vascular Biology Laboratory, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada
    J Cardiovasc Pharmacol 58:399-405. 2011
    ..Recent studies suggest that modulation of estrogen receptor β (ERβ) may play a crucial role in maintaining vascular homeostasis. We hypothesized that selective ERβ activation will attenuate atherogenesis via anti-inflammatory mechanisms...
  46. doi Opposing roles of ERα and ERβ in the genesis and progression of adenocarcinoma in the rat ventral prostate
    D M A Attia
    Women s Health Department, MSD, Oss, The Netherlands
    Prostate 72:1013-22. 2012
    ..To differentiate between the roles both receptors play in prostate cancer an ERα and an ERβ agonist, ERA-45 and ERB-26, have been tested in a rodent model for prostate carcinogenesis...
  47. pmc Diffusion weighted imaging evaluated the early therapy effect of tamoxifen in an MNU-induced mammary cancer rat model
    Guihua Zhai
    The Department of Radiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    PLoS ONE 8:e64445. 2013
    ..To assess the optimal time point of diffusion-weighted imaging (DWI) for early prognosis of breast cancer following tamoxifen therapy using a methylnitrosourea (MNU)-induced ER-positive breast-cancer model...
  48. pmc Age-dependent Effects of 17β-estradiol on the dynamics of estrogen receptor β (ERβ) protein-protein interactions in the ventral hippocampus
    Natasha N Mott
    Department of Cell and Molecular Physiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153
    Mol Cell Proteomics 13:760-79. 2014
    ..Thus, our data provide evidence that changes in ERβ protein interactions are a potential mechanism for age-related changes in E2 responsiveness in the brain after menopause. ..
  49. doi Effect of estrogen receptor-subtype-specific ligands on fertility in adult male rats
    Kushaan Dumasia
    Department of Neuroendocrinology National Institute for Research in Reproductive Health Indian Council of Medical Research, Parel, Mumbai 400 012, India
    J Endocrinol 225:169-80. 2015
    ....
  50. doi Both estrogen receptor subtypes, ERα and ERβ, prevent aldosterone-induced oxidative stress in VSMC via increased NADPH bioavailability
    Melanie Muehlfelder
    Department of Medicine, University of Wuerzburg, Germany
    Biochem Biophys Res Commun 423:850-6. 2012
    ..In conclusion, estrogens attenuate the detrimental vascular effects of excessive MR activation at least in part by preventing the depletion of intracellular NADPH levels...
  51. doi Synergistic inhibitory effect of nicotine plus oral contraceptive on mitochondrial complex-IV is mediated by estrogen receptor-β in female rats
    Ami P Raval
    Cerebral Vascular Disease Research Laboratories, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Neurochem 121:157-67. 2012
    ..Overall, these results suggest that mitochondrial ER-β loss is responsible for mitochondrial malfunction after NOC...
  52. doi Selective estrogen receptor-β activation stimulates skeletal muscle growth and regeneration
    Martina Velders
    Department Molecular and Cellular Sports Medicine, Deutsche Sporthochschule Koln, Am Sportpark Müngersdorf 6, 50933 Koln, Germany
    FASEB J 26:1909-20. 2012
    ..Our data provide evidence that ERβ signaling is involved in the regulation of skeletal muscle growth and regeneration by stimulating anabolic pathways, activating satellite cells and modulating immune responses...
  53. doi Differential expression of estrogen receptors in two hippocampal regions during the estrous cycle of the rat
    Luciano Mendoza-Garcés
    Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico, Distrito Federal, Mexico
    Anat Rec (Hoboken) 294:1913-9. 2011
    ....
  54. doi 17β-Estradiol regulates the gene expression of voltage-gated sodium channels: role of estrogen receptor α and estrogen receptor β
    Fang Hu
    Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing 210029, China
    Endocrine 41:274-80. 2012
    ..We also found that E2-regulation of Nav1.1 and Nav1.9 mRNA expressions is dependent on ERα, ERβ, and another ER, whereas E2-regulation of Nav1.8 appears to be in an ERβ-dependent manner...
  55. pmc Distribution and estrogen regulation of membrane progesterone receptor-β in the female rat brain
    Damian G Zuloaga
    Department of Basic Medical Sciences, University of Arizona College of Medicine, 425 North 5th Street, Phoenix, Arizona 85004, USA
    Endocrinology 153:4432-43. 2012
    ..Furthermore, E(2) regulation of mPRβ indicates a mechanism through which estrogens can regulate P(4) function within discrete brain regions to potentially impact behavior...
  56. ncbi Expression of estrogen receptor α and β in rat astrocytes in primary culture: effects of hypoxia and glucose deprivation
    M D Al-Bader
    Department of Physiology, Faculty of Medicine, Kuwait University, Kuwait
    Physiol Res 60:951-60. 2011
    ..exerts biological effects through interaction with its two receptors: estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ), which are both expressed in astrocytes...
  57. doi Association between estrogen receptor-β dinucleotide repeat polymorphism and incidence of femoral fracture
    Naoko Honma
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo, 173 0015, Japan
    J Bone Miner Metab 31:96-101. 2013
    ..Dinucleotide (cytosine-adenine, CA) repeat polymorphism in the human ER-β gene (ESR2) has been reported to be associated with bone mineral density...
  58. doi Different associations of estrogen receptor β isoforms, ERβ1 and ERβ2, expression levels with tumor size and survival in early- and late-onset breast cancer
    Vesna Mandusić
    Deutsches Krebsforschungszentrum DKFZ, Molecular Genetics of Breast Cancer, Heidelberg, Germany
    Cancer Lett 321:73-9. 2012
    ..Previously reported correlations have been based mostly on independent ERα and ERβ expression levels in breast tumors...
  59. pmc Generation and reproductive phenotypes of mice lacking estrogen receptor beta
    J H Krege
    Department of Pathology, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 95:15677-82. 1998
    ..Here we describe the generation of mice lacking estrogen receptor beta (ERbeta -/-) by insertion of a neomycin resistance gene into exon 3 of the coding gene by using homologous ..
  60. ncbi Expression of estrogen receptor alpha and beta in the epiphyseal plate of the rat
    B C J van der Eerden
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Bone 30:478-85. 2002
    ..Using in situ hybridization and immunohistochemistry, we demonstrated ER alpha and ER beta mRNA and protein in tibial growth plates from 1 to 40 weeks after birth...
  61. ncbi Genistein affects ER beta- but not ER alpha-dependent gene expression in the hypothalamus
    Heather B Patisaul
    Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30329, USA
    Endocrinology 143:2189-97. 2002
    ..phytoestrogens, inhibited estrogen-dependent female sexual behavior and was antiestrogenic for both ER alpha- and ER beta-dependent gene expression in the hypothalamus...
  62. ncbi Alfa and beta estrogen receptors and the biliary tree
    Domenico Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, University of Rome La Sapienza, Via valsolda 45 i, 00141 Rome, Italy
    Mol Cell Endocrinol 193:105-8. 2002
    ..This indicates a major involvement of the ERK system in the estrogen modulation of cholangiocyte proliferation...
  63. pmc An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth
    Zhang Weihua
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 99:13589-94. 2002
    ..We have used ERbeta(-/-) and CYP7B1(-/-) mice to investigate the role of ERbeta and one of its ligands, 5alpha-androstane-3beta,17beta-..
  64. ncbi Isoform specificity for oestrogen receptor and thyroid hormone receptor genes and their interactions on the NR2D gene promoter
    N Vasudevan
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY, USA
    J Neuroendocrinol 14:836-42. 2002
    ..of the oestrogen receptor (ER) exists in mammals, it is possible that oestrogen regulation via the ERalpha and ERbeta isoforms on the NR2D oestrogen response element (ERE) is not equivalent...
  65. ncbi Age-related changes in estrogen receptor beta in rat hypothalamus: a quantitative analysis
    Tandra R Chakraborty
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Brookdale Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 144:4164-71. 2003
    Although the estrogen receptor beta (ER beta) is a major target for actions of estrogen on the brain, little is known about its neural expression during aging, when levels and the mode of estrogen release undergo substantial changes...
  66. ncbi Lack of functional estrogen receptor beta gene disrupts pubertal male sexual behavior
    Jennifer L Temple
    Cellular and Developmental Neurobiology Section, National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 4156, USA
    Horm Behav 44:427-34. 2003
    The estrogen receptor-beta (ERbeta) mediates estrogen action in the female gonads, reproductive tract, and central nervous system. In addition, in rats and mice, gonadotropin-releasing hormone (GnRH-I) neurons coexpress ERbeta...
  67. ncbi Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression
    M Blurton-Jones
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093 0626, USA
    J Comp Neurol 468:347-60. 2004
    ....
  68. ncbi Membrane-associated estrogen receptor and caveolin-1 are present in central nervous system myelin and oligodendrocyte plasma membranes
    Dina N Arvanitis
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    J Neurosci Res 75:603-13. 2004
    ..We have shown that an ER with similarities to ERbeta is present in isolated central nervous system (CNS) myelin, the myelin sheath in spinal cord and brain sections, ..
  69. ncbi Dissecting physiological roles of estrogen receptor alpha and beta with potent selective ligands from structure-based design
    Alexander Hillisch
    EnTec Gesellschaft für Endokrinologische Technologie GmbH, D 13342 Berlin, Germany
    Mol Endocrinol 18:1599-609. 2004
    The distinct roles of the two estrogen receptor (ER) isotypes, ERalpha and ERbeta, in mediating the physiological responses to estrogens are not completely understood...
  70. ncbi Downregulation of estrogen receptor alpha and beta expression in carcinogen-induced mammary gland tumors of rats
    Jin Seok Kang
    National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122 704, South Korea
    Eksp Onkol 26:31-5. 2004
    The recent discovery of a new isoform of estrogen receptor (ER), ER beta, has promoted the investigation of its expression on mammary gland...
  71. ncbi Sex-dependent association of blood pressure with oestrogen receptor genes ERalpha and ERbeta
    Justine A Ellis
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    J Hypertens 22:1127-31. 2004
    There is mounting physiological evidence for an important role of the oestrogen receptors, ERalpha and ERbeta, in vasodilatation and the response to vascular injury...
  72. ncbi Sexual dimorphism in the content of progesterone and estrogen receptors, and their cofactors in the lung of adult rats
    Aliesha González-Arenas
    Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Coyoacan 04510, Mexico, D F, Mexico
    Steroids 69:351-6. 2004
    ..Our results suggest a sexual dimorphism in the content of PR, ER-beta, and SMRT in the rat lung as well as a relation of their content to the physiological levels of progesterone and estradiol...
  73. ncbi Difference in skeletal muscle function in males vs. females: role of estrogen receptor-beta
    Birgitta Glenmark
    Department of Hand Surgery, Stockholm Soder Hospital, SE 118 83 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 287:E1125-31. 2004
    ..We studied the role of estrogen receptor-beta (ERbeta) in this gender difference by comparing contractile function of soleus (mainly slow-twitch) and extensor digitorum ..
  74. ncbi Immunocytochemical localization of estrogen receptor beta in the rat brain
    Ji Qiang Zhang
    Department of Histology and Embryology, The Third Military Medical University, Chongqing 400038, PR China
    Shi Yan Sheng Wu Xue Bao 35:15-20. 2002
    ..The above results provide the first detailed evidence that ER-beta protein is widely distributed in the rat brain, and ER-beta may be involved in some important brain function such as learning and memory...
  75. pmc Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors
    Ratna K Vadlamudi
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    J Clin Endocrinol Metab 89:6130-8. 2004
    ..model cell line and ER subtype-specific ligands, we found that PELP1 functionally interacts with both ERalpha and ERbeta and enhances their transcriptional responses...
  76. ncbi A selective estrogen receptor-beta agonist causes lesion regression in an experimentally induced model of endometriosis
    Heather A Harris
    Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
    Hum Reprod 20:936-41. 2005
    ..ERB-041 is a selective estrogen receptor-beta (ERbeta) agonist that has anti-inflammatory activity in preclinical models of arthritis and inflammatory bowel disease, ..
  77. ncbi Transcriptional regulation of tyrosine hydroxylase by estrogen: opposite effects with estrogen receptors alpha and beta and interactions with cyclic AMP
    Shreekrishna Maharjan
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    J Neurochem 93:1502-14. 2005
    ..PC12 cells, transiently co-transfected with expression vector for ERalpha or ERbeta, and luciferase gene under control of the TH promoter, were treated with 17 beta-estradiol (E2)...
  78. ncbi Organ messenger ribonucleic acid and plasma proteome changes in the adjuvant-induced arthritis model: responses to disease induction and therapy with the estrogen receptor-beta selective agonist ERB-041
    Maximillian T Follettie
    Biological Technologies, Wyeth Research, Cambridge, Massachusetts 02140, USA
    Endocrinology 147:714-23. 2006
    Two receptors [estrogen receptor (ER)alpha and ERbeta] mediate the manifold effects of estrogens throughout the body...
  79. ncbi Differential expression of the estrogen receptors alpha and beta during postnatal development of the rat cerebellum
    Yayoi Ikeda
    Department of Histology and Cell Biology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Brain Res 1083:39-49. 2006
    ..In contrast, expression levels of cerebellar ERbeta mRNA remained significantly unchanged during postnatal development...
  80. ncbi WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock
    Patricia A Cristofaro
    Infectious Disease Division, Memorial Hospital of Rhode Island, Brown Medical School, Providence, RI, USA
    Crit Care Med 34:2188-93. 2006
    ..To determine the effect of an estrogen receptor-beta selective agent in experimental models of systemic infection and sepsis...
  81. ncbi Estrogen receptor beta gene (ESRbeta) 3'-UTR variants in Alzheimer disease
    Christian Luckhaus
    Alzheimer Dis Assoc Disord 20:322-3. 2006
  82. ncbi Effects of estrogen receptor subtype-selective agonists on autoimmune disease in lupus-prone NZB/NZW F1 mouse model
    Jing Li
    Department of Endocrinology, The First Hospital Affiliated to China Medical University, Shenyang, 110001, P R China
    Clin Immunol 123:219-26. 2007
    ..In contrast, diarylpropionitrile (ERbeta-selective agonist) administration significantly decreased serum anti-DNA IgG2b level but did not significantly ..
  83. ncbi Ciliated epithelial-specific and regional-specific expression and regulation of the estrogen receptor-beta2 in the fallopian tubes of immature rats: a possible mechanism for estrogen-mediated transport process in vivo
    Ruijin Shao
    Instiute of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University, SE 41390 Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 293:E147-58. 2007
    ..We show for the first time that a previously unrecognized localization of ERbeta isoform in rat fallopian tubes can combine with estrogen to individually control the expression of ER beta-isoforms in normal target tissues.
  84. pmc Distribution and localization patterns of estrogen receptor-beta and insulin-like growth factor-1 receptors in neurons and glial cells of the female rat substantia nigra: localization of ERbeta and IGF-1R in substantia nigra
    Arnulfo Quesada
    Department of Neurobiology, Laboratory of Neuroendocrinology of the Brain Research Institute, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    J Comp Neurol 503:198-208. 2007
    ..TH-ir) SN pars compacta (SNpc) DA neurons are immunoreactive for estrogen receptor-beta (ERbeta). No immunolabeling for ERalpha was observed...
  85. ncbi Age-related changes in the expression of ER-beta mRNA in the female rat brain
    Naoko Yamaguchi-Shima
    Department of Neurobiology and Anatomy, Kochi Medical School, Kochi University, Kohasu, Kochi, Japan
    Brain Res 1155:34-41. 2007
    ..These results indicate that the expression of ER-beta mRNA in the female rat brain is differentially modulated during aging and that the changes are region specific...
  86. pmc Effects of organisational oestradiol on adult immunoreactive oestrogen receptors (alpha and beta) in the male mouse brain
    A E Kudwa
    Neuroscience Graduate Program, University of Virginia, Charlottesville, VA 22908, USA
    J Neuroendocrinol 19:767-72. 2007
    ..that developmental exposure to oestradiol (E(2)) organises the quantity of adult oestrogen receptors (ERalpha and ERbeta), we used male mice with a targeted mutation of the aromatase enzyme gene (ArKO) and their wild-type (WT) ..
  87. ncbi 17beta-estradiol induces the translocation of the estrogen receptors ESR1 and ESR2 to the cell membrane, MAPK3/1 phosphorylation and proliferation of cultured immature rat Sertoli cells
    Thaís F G Lucas
    Section of Experimental Endocrinology, Department of Pharmacology, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil
    Biol Reprod 78:101-14. 2008
    ..RT-PCR detected transcripts for the estrogen receptors ESR1 and ESR2 in cultured immature Sertoli cells and in the testis of 15-, 28-, and 120-day-old rats...
  88. ncbi Ligand-dependent activation of ER{beta} lowers blood pressure and attenuates cardiac hypertrophy in ovariectomized spontaneously hypertensive rats
    Virginija Jazbutyte
    Department of Medicine, University of Wurzburg, Josef Schneider Str 2, Wurzburg, Germany
    Cardiovasc Res 77:774-81. 2008
    The biological effects of oestrogens are mediated by two different oestrogen receptor (ER) subtypes, ERalpha and ERbeta, which might play different, redundant, or opposing roles in cardiovascular disease...
  89. ncbi Oestrogen receptor alpha and beta in female rat pituitary cells: an immunochemical study
    Miriam Gonzalez
    Cell Biology Section, University of La Laguna School of Biology and FICIC, 38230 La Laguna, Tenerife, Spain
    Gen Comp Endocrinol 155:857-68. 2008
    ..Previous reports have demonstrated the presence of oestrogen receptor alpha (ERalpha) and beta (ERbeta) in specific anterior pituitary cells from ovariectomized rats, as well as in the whole anterior pituitary at ..
  90. pmc Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Steroids 73:997-1007. 2008
    ..Administration of ligands that are specific for ERbeta, but not ERalpha, have enhancing effects on hippocampal processes similar to that of E(2) (which has similar ..
  91. doi Estrogen receptor subtype-specific effects on markers of bone homeostasis
    T Hertrampf
    Institut für Kreislaufforschung und Sportmedizin, Abt molekulare und zelluläre Sportmedizin, DSHS Köln, Germany
    Mol Cell Endocrinol 291:104-8. 2008
    ..rats were treated subcutaneously with 17beta-estradiol (E(2)), the ERalpha-specific agonist (16alpha-LE2) and the ERbeta-specific agonist (8beta-VE2). OVX and intact animals served as controls...
  92. pmc Prepubertal physical activity up-regulates estrogen receptor beta, BRCA1 and p53 mRNA expression in the rat mammary gland
    M Wang
    Department of Oncology, Georgetown University, Washington, DC, USA
    Breast Cancer Res Treat 115:213-20. 2009
    ..It remains to be determined whether the up-regulation of BRCA1, and perhaps p53, explains the protective effect of childhood physical activity against breast cancer in women who carry a germline mutation in one of the BRCA1 alleles...
  93. pmc Converse regulatory functions of estrogen receptor-alpha and -beta subtypes expressed in hypothalamic gonadotropin-releasing hormone neurons
    Lian Hu
    Endocrinology and Reproduction Research Branch, PDEGEN, National Institue of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    Mol Endocrinol 22:2250-9. 2008
    ..In this study, Single-cell RT-PCR revealed the expression of both ERalpha and ERbeta isoforms in cultured fetal and adult rat hypothalamic GnRH neurons...
  94. doi The localization and non-genomic function of the membrane-associated estrogen receptor in oligodendrocytes
    Yukie Hirahara
    Division of Molecular Structure and Function, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Glia 57:153-65. 2009
    ..b>ERbeta was located in the nucleus, and to a lesser extent along the veins...
  95. pmc Role of estrogen receptor subtypes in estrogen-induced organ-specific vasorelaxation after trauma-hemorrhage
    Zheng F Ba
    Center for Surgical Research, University of Alabama, 1670 Univ Blvd, G094 Volker Hall, Birmingham, AL 35294 0019, USA
    Am J Physiol Heart Circ Physiol 295:H2061-7. 2008
    ..E2) and ER-specific agonists propylpyrazole triol (PPT; ERalpha agonist) and diarylpropionitrile (DPN; ERbeta agonist) were determined...
  96. pmc Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones
    A Jayaraman
    Neuroscience Graduate Programme and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089 0191, USA
    J Neuroendocrinol 21:77-81. 2009
    ..can modulate oestrogen actions by regulating the expression and activity of oestrogen receptors, ERalpha and ERbeta. Our studies in cultured neurones demonstrate that progesterone decreases the expression of both ERalpha and ..
  97. doi Breast cancer, estrogen receptor and ligands
    Zhenlin Bai
    Institute of Pharmacy, Freie Universitat Berlin, Knigin Luise Strasse 2 4, Berlin, Germany
    Arch Pharm (Weinheim) 342:133-49. 2009
    ....
  98. pmc Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells
    Xin Miao Fu
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, 66160, USA
    J Steroid Biochem Mol Biol 115:20-9. 2009
    ....
  99. doi Gene expression profiling identifies key estradiol targets in the frontal cortex of the rat
    Miklós Sárvári
    Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, Budapest H 1083, Hungary
    Endocrinology 151:1161-76. 2010
    ..Identification of estradiol-regulated genes in the frontal cortex helps to understand the pathomechanism of neurological and psychiatric disorders associated with altered levels of estrogens...
  100. pmc Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats
    Danielle Doucet
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 5:e9421. 2010
    ..to T/HS-induced gut and distant organ injury, the goal of our study was to determine the contribution of estrogen receptor (ER)alpha and ERbeta in modulating the protective response of female rats to T/HS-induced gut and lung injury.

Research Grants8

  1. ESTROGEN COMPOUNDS, COGNITION & DEMENTIA IN OLDER WOMEN
    Kristine Yaffe; Fiscal Year: 2002
    ..This award will foster the applicant's development towards becoming an independent investigator in aging research. ..
  2. ESTROGEN IMPRINTING OF PROSTATE GLAND VIA METHYLATON
    Gail Prins; Fiscal Year: 2005
    ....
  3. Metabolic Syndrome and Cognitive Impairment
    Kristine Yaffe; Fiscal Year: 2005
    ..If elders with metabolic syndrome have increased risk of developing cognitive impairment, this would have important clinical and public health significance. ..
  4. ECM Regulation by Estrogen in ARMD
    Sharon Elliot; Fiscal Year: 2006
    ..Conversely, we expect that estrogen's antioxidant action on the cell membrane will diminish MPO-induced blebbing and that activation of estrogen receptors will modify matrix molecule dysregulation. ..
  5. Sex Hormones, Related Polymorphisms & Cognitive Decline
    Kristine Yaffe; Fiscal Year: 2006
    ..Further knowledge of the association between sex hormones, hormone-related polymorphisms and cognitive decline may facilitate preventative strategies to maintain independence and to promote optimum brain aging. ..
  6. Development Estrogenization of the Rat Prostate Gland
    Gail S Prins; Fiscal Year: 2010
    ..Results will further define the mechanisms of estrogen's actions on the prostate gland during early development and lead to a better understanding of the hormonal and developmental basis for abnormal prostate growth with aging...
  7. Estrogen Modulates Dopamine Signaling
    JILL SHARIFI; Fiscal Year: 2005
    ..Data collected will provide important evidence for estrogen's role in the modulation of the nucleus accumbens reward system and drugs of abuse. ..
  8. Female Reproductive Organs and Their Innervation.
    RAYMOND PAPKA; Fiscal Year: 2006
    ..Finally, knowledge of estrogen responsive sensory neurons has important implications for understanding neuropathic pain syndromes influenced by estrogen levels. ..