Ednra

Summary

Gene Symbol: Ednra
Description: endothelin receptor type A
Alias: ET-A, ET-AR, Endor, Eta, RGD1559432, endothelin-1 receptor, endothelin A receptor, endothelin-1 receptor-like
Species: rat

Top Publications

  1. ncbi Endothelin-1 stimulated capacitative Ca2+ entry through ET(A) receptors of a rat brain-derived type-1 astrocyte cell line, IA-1g1
    You Jing Ju
    Institute of Neuroscience, College of Life Science, National Yang Ming University, 155, Section 2, Li Non Street, Shi Pai, Taipei, Taiwan, ROC
    Cell Signal 15:197-207. 2003
  2. ncbi Endothelin-A receptor blockade improves postischemic hepatic microhemodynamics
    Dirk Uhlmann
    Second Department of Surgery, University of Leipzig, Germany
    J Cardiovasc Pharmacol 44:S103-4. 2004
  3. doi Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea
    Elise Belaidi
    INSERM, Grenoble, France
    J Am Coll Cardiol 53:1309-17. 2009
  4. pmc BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension
    M Talati
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 27232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 299:L363-73. 2010
  5. pmc Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat
    Mohamed A Saleh
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 56:942-9. 2010
  6. doi Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts
    Masashi Tawa
    Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Eur J Pharmacol 591:182-8. 2008
  7. pmc Contribution of endothelin A receptors in endothelin 1-dependent natriuresis in female rats
    Daisuke Nakano
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Hypertension 53:324-30. 2009
  8. doi Inhibitory effects of PPAR-gamma on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats
    Augusto C Montezano
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Am Soc Hypertens 1:150-60. 2007
  9. ncbi Enhanced expression of renal endothelin-converting enzyme-1 and endothelin-A-receptor mRNA in rats with interstitial fibrosis following ureter ligation
    D L Feldman
    Metabolic and Cardiovascular Diseases, Novartis Institute for Biomedical Research, Summit, NJ, USA
    J Cardiovasc Pharmacol 36:S255-9. 2000
  10. ncbi Involvement of endothelin-1 and its receptors in PGF2alpha-induced luteolysis in the rat
    Eliezer Girsh
    Department of Biological Regulation, Weizmann Institute, Rehovot, Israel
    Mol Reprod Dev 63:71-8. 2002

Scientific Experts

Detail Information

Publications116 found, 100 shown here

  1. ncbi Endothelin-1 stimulated capacitative Ca2+ entry through ET(A) receptors of a rat brain-derived type-1 astrocyte cell line, IA-1g1
    You Jing Ju
    Institute of Neuroscience, College of Life Science, National Yang Ming University, 155, Section 2, Li Non Street, Shi Pai, Taipei, Taiwan, ROC
    Cell Signal 15:197-207. 2003
    ..Thus, protein kinase C (PKC) negatively regulated and cAMP-dependent protein kinase (PKA) positively regulated the ET-1-mediated CCE in these cells...
  2. ncbi Endothelin-A receptor blockade improves postischemic hepatic microhemodynamics
    Dirk Uhlmann
    Second Department of Surgery, University of Leipzig, Germany
    J Cardiovasc Pharmacol 44:S103-4. 2004
    ..It could be shown for the first time that endothelin receptor blockade also influences platelet-endothelium interactions...
  3. doi Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea
    Elise Belaidi
    INSERM, Grenoble, France
    J Am Coll Cardiol 53:1309-17. 2009
    ..Our aim was to investigate the involvement of the endothelin (ET) system in the cardiovascular consequences of intermittent hypoxia (IH)...
  4. pmc BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension
    M Talati
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 27232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 299:L363-73. 2010
    ..This is the first description of protein expression that distinguishes HPAH from IPAH in patients...
  5. pmc Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat
    Mohamed A Saleh
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 56:942-9. 2010
    ..These data support the hypothesis that ET-1 directly increases glomerular permeability to albumin and renal inflammation via ET(A) receptor activation independent of changes in arterial pressure...
  6. doi Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts
    Masashi Tawa
    Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Eur J Pharmacol 591:182-8. 2008
    ....
  7. pmc Contribution of endothelin A receptors in endothelin 1-dependent natriuresis in female rats
    Daisuke Nakano
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Hypertension 53:324-30. 2009
    ..Treatment with ABT-627, an endothelin A receptor antagonist, or N(G)-propyl-L-arginine, an NO synthase 1 inhibitor, prevented the increase in U(Na)V ..
  8. doi Inhibitory effects of PPAR-gamma on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats
    Augusto C Montezano
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Am Soc Hypertens 1:150-60. 2007
    ..These effects may be abrogated by the PPAR-gamma activator rosiglitazone. PPAR-gamma activators may thus prevent deleterious ET-1-dependent proinflammatory vascular effects in VSMC in hypertension...
  9. ncbi Enhanced expression of renal endothelin-converting enzyme-1 and endothelin-A-receptor mRNA in rats with interstitial fibrosis following ureter ligation
    D L Feldman
    Metabolic and Cardiovascular Diseases, Novartis Institute for Biomedical Research, Summit, NJ, USA
    J Cardiovasc Pharmacol 36:S255-9. 2000
    ..These results suggest that ET-1, through interaction with the ET(A)-receptors, may play a role in the progression of interstitial fibrosis following ureter ligation...
  10. ncbi Involvement of endothelin-1 and its receptors in PGF2alpha-induced luteolysis in the rat
    Eliezer Girsh
    Department of Biological Regulation, Weizmann Institute, Rehovot, Israel
    Mol Reprod Dev 63:71-8. 2002
    ..Expression of the ET receptors, ETA and ETB was not affected by cloprostenol...
  11. doi Differential roles of endothelin-1 ETA and ETB receptors and vasoactive intestinal polypeptide in regulation of the airways and the pulmonary vasculature in isolated rat lung
    Tibor Janosi
    Paediatric Anaesthesia Unit, Geneva Children s Hospital, Rue Willy Donze 6, CH 1205 Geneva, Switzerland
    Exp Physiol 93:1210-9. 2008
    ..Our results suggest that VIP potently acts against the airway and pulmonary vascular constriction mediated by endothelin-1, while the ET(A) and ET(B) blockers exert a differential effect between airway resistance and PVR...
  12. pmc Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor
    Alejandro P Comellas
    Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Respir Crit Care Med 179:113-22. 2009
    ..Endothelin-1 (ET-1) is increased in patients with high-altitude pulmonary edema and acute respiratory distress syndrome, and these patients have decreased alveolar fluid reabsorption (AFR)...
  13. doi Thrombin-stimulated proliferation is mediated by endothelin-1 in cultured rat gingival fibroblasts
    Nozomi Ohuchi
    Laboratory of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283 8555, Japan
    Fundam Clin Pharmacol 24:501-8. 2010
    ..These findings suggest that thrombin, acting via PAR1, induced proliferation of cultured rat gingival fibroblasts that was mediated by ET-1 acting via ET(A)...
  14. doi Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats
    Y Chen
    First Dept of Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Eur Respir J 35:904-12. 2010
    ..ET-1 may cause emphysematous changes through molecular pathogenesis pathways involving apoptosis, proteinase and antiproteinase imbalance, inflammation and oxidative stress...
  15. ncbi Endothelin-1-induced pulmonary vasoreactivity is regulated by ET(A) and ET(B) receptor interactions
    Stephanie Sauvageau
    Research Center, Montreal Heart Institute, Montreal, Que, Canada
    J Vasc Res 44:375-81. 2007
    ..This stems from endothelial ET(B)-R that can release both vasodilators and vasoconstrictors. The aim of this study was to evaluate the roles of the endothelium and of ET-Rs on ET-1-induced pulmonary vasoreactivity...
  16. ncbi Cholesterol dependence of vascular ERK1/2 activation and growth in response to stretch: role of endothelin-1
    Asad Zeidan
    Division of Molecular and Cellular Physiology, Department of Physiological Sciences, Lund University, Biomedical Centre, Lund, Sweden
    Arterioscler Thromb Vasc Biol 23:1528-34. 2003
    ..This study tested the role of rafts/caveolae in stretch-induced vascular growth by manipulation of membrane cholesterol contents...
  17. ncbi Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells
    Linda Yahiaoui
    Meakins Christie Laboratories, Department of Medicine, McGill University, St Urbain, Montreal, Quebec
    Cell Physiol Biochem 17:37-46. 2006
    ..Our data indicate that ET-1 activation of the ET A receptor subtype induced [(3)H]-thymidine incorporation and activation of ERK 1/2 in primary rat tracheal SMC...
  18. pmc Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice
    H Yanagisawa
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9050, USA
    J Clin Invest 102:22-33. 1998
    ..generated from its inactive precursor by endothelin-converting enzyme-1 (ECE-1) and acts on the endothelin-A (ETA) receptor...
  19. ncbi Association between migraine and endothelin type A receptor (ETA -231 A/G) gene polymorphism
    C Tzourio
    INSERM U 360, Salpetriere Hospital, Paris, France
    Neurology 56:1273-7. 2001
    ..Previous studies have described an association between migraine and endothelin, a potent vasoconstrictor...
  20. ncbi Regulation of endothelin-A receptor sensitivity by cyclic adenosine monophosphate in rat hepatic stellate cells
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich Heine Universitat, Dusseldorf, Germany
    Hepatology 36:861-73. 2002
    ..This may explain the transdifferentiation-dependent sensitization of HSC towards ET-1 and its reversal by cAMP and ET(B) activation...
  21. ncbi Age-related changes in the properties of the endothelin receptor system at protein and mRNA levels in the rat vas deferens
    Makoto Yono
    Section of Urology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Recept Signal Transduct Res 24:53-66. 2004
    ..These results demonstrate the presence of age-related changes in the properties of the ET receptor system at both protein and mRNA levels in the rat vas deferens...
  22. ncbi Influence of endothelin receptor antagonism on smooth muscle cell proliferation after chronic renal failure
    Gabriele Sauter
    University of Tubingen, Internal Medicine III, Tubingen, Germany
    J Cardiovasc Pharmacol 44:S165-7. 2004
    ..This indicates a regulatory influence of these drugs on gene transcription and supports the importance of early treatment to inhibit coronary artery disease in uremic patients...
  23. ncbi Effect of YM598, a selective endothelin ETA receptor antagonist, on endothelin-1-induced bone formation
    Akiyoshi Someya
    Pharmacology Laboratories, Institute for Drug Discovery Research, Astellas Pharma, Inc 21, Miyukigaoka, Tsukuba shi, Ibaraki 305 8585, Japan
    Eur J Pharmacol 543:14-20. 2006
    ..These results suggest that endothelin-1 may induce bone formation via endothelin ET(A) receptors in vitro and in vivo...
  24. ncbi [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]
    Yang Zhou
    Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    Zhong Xi Yi Jie He Xue Bao 5:61-4. 2007
    ..To investigate the effects of salvianolic acid B (SA-B) on portal hypertension induced by endothelin-1 in rats...
  25. pmc Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1
    Raksha Jain
    Division of Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Respir Cell Mol Biol 37:38-47. 2007
    ..These findings increase our basic understanding of the role of ET-1 in pulmonary fibrosis and suggest potential roles for AEC-derived ET-1 in the pathogenesis of other alveolar epithelial-mediated lung diseases...
  26. ncbi Cardiac effects of endothelin receptor antagonism in endotoxemic pigs
    D Konrad
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Am J Physiol Heart Circ Physiol 293:H988-96. 2007
    ..Positive hemodynamic effects from ET receptor antagonism in acute endotoxemia may be due to changes in cardiac load and enhanced diastolic function rather than improved contractile function...
  27. ncbi Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice
    Martin Richter
    Institute of Pharmacology of Sherbrooke, Medical School, Sherbrooke University, 3001, 12 e Avenue Nord, Sherbrooke Qc Canada J1H 5N4
    Prostaglandins Leukot Essent Fatty Acids 76:299-308. 2007
    ..These results suggest an important role for endothelin, PAF and thromboxane A2 in AHR in mice actively sensitized and challenged with ovalbumin...
  28. ncbi Cooperative effect of angiotensin AT(1) and endothelin ET(A) receptor antagonism limits the brain damage after ischemic stroke in rat
    Emelie Stenman
    Institution of Clinical Sciences Lund, Department of Experimental Vascular Research, Lund University, BMC A13, 22184 Lund, Sweden
    Eur J Pharmacol 570:142-8. 2007
    ..In conclusion, the present study shows that combined inhibition of angiotensin AT(1) and endothelin ET(A) receptors reduces the brain damage and improves the neurological outcome after ischemic stroke in rat...
  29. doi Mechanical stretch induced interleukin-18 (IL-18) expression through Angiotensin subtype 1 receptor (AT1R) and endothelin-1 in cardiomyocytes
    Toshio Naka
    Department of Internal Medicine, Division of Coronary Heart Disease, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Prep Biochem Biotechnol 38:201-12. 2008
    ..Mechanical stretch induces a hypertrophic response, partly through the production of ET-1 through Endothelin A receptor (ETAR)...
  30. doi Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy
    Circulation 117:3010-9. 2008
    ..Ambrisentan is a propanoic acid-based, A-selective endothelin receptor antagonist for the once-daily treatment of pulmonary arterial hypertension...
  31. pmc Diabetic state, high plasma insulin and angiotensin II combine to augment endothelin-1-induced vasoconstriction via ETA receptors and ERK
    T Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo, Japan
    Br J Pharmacol 155:974-83. 2008
    ..Functions for angiotensin II, endothelin-1 receptor expression and extracellular signal-regulated kinase (ERK) have been investigated...
  32. doi Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat
    Takayuki Matsumoto
    Dept of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi Univ, Shinagawa ku, Tokyo 142 8501, Japan
    Am J Physiol Heart Circ Physiol 296:H1388-97. 2009
    ..These results suggest that upregulation of ET(A), a defect in ET(B)-mediated NO signaling, and activation of the MEK/ERK pathway together represent a likely mechanism mediating the hyperreactivity to ET-1 examined in this study...
  33. pmc Increased endothelin-1 reactivity and endothelial dysfunction in carotid arteries from rats with hyperhomocysteinemia
    C R de Andrade
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Br J Pharmacol 157:568-80. 2009
    ..Here we evaluated the effects of HHcy on the endothelin system in rat carotid arteries...
  34. pmc Murine and rat cavernosal responses to endothelin-1 and urotensin-II Vasoactive Peptide Symposium
    Fernando S Carneiro
    Medical College of Georgia, Department of Physiology, Augusta, GA, USA
    J Am Soc Hypertens 2:439-447. 2008
    ..Although the cavernosal tissue expresses U-II receptors, U-II does not induce contractile responses in corpora cavernosa from mice or rats...
  35. doi Increased ET-1 and reduced ET(B) receptor expression in uremic hypertensive rats
    Martin D'Amours
    CHUQ Research Center and Division of Nephrology and Hypertension, L Hôtel Dieu de Québec Hospital and Department of Medicine, Laval University, Quebec, Canada
    Clin Exp Hypertens 32:61-9. 2010
    ..This study reveals that ET-1 levels are augmented in the vascular endothelium of uremic rats, whereas the ET(B) receptor expression is reduced which may play a major role in hypertension and renal failure progression...
  36. doi Production and binding of endothelin-2 (EDN2) in the rat ovary: endothelin receptor subtype A (EDNRA)-mediated contraction
    Phillip J Bridges
    Division of Clinical and Reproductive Sciences, University of Kentucky, Lexington, KY 40536, USA
    Reprod Fertil Dev 22:780-7. 2010
    ..3, isometric tension analysis revealed that the contractile effect of EDN2 was mediated by endothelin receptor A (EDNRA), not B (EDNRB)...
  37. doi Inhibition of endothelin-1 and hypoxia-induced pulmonary pressor responses in the rat by a novel selective endothelin-A receptor antagonist, di-n-butylaminocarbamyl-L-leucyl-D-tryptophanyl-D-4-chloro-Phe
    Ling Di Yan
    Beijing Institute of Pharmacology and Toxicology, Haidian District, Beijing, China
    J Cardiovasc Pharmacol 56:246-54. 2010
    ..Aiming at developing new endothelin-A receptor (ETA) antagonist for treatment of pulmonary hypertension, di-n-butylaminocarbamyl-L-leucyl-D-tryptophanyl-D-4-chloro-Phe,..
  38. pmc Activation of endothelin A receptors contributes to impaired responsiveness of renal mechanosensory nerves in congestive heart failure
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, and University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Can J Physiol Pharmacol 88:622-9. 2010
    ..Therefore, we examined whether the ETA receptor antagonist BQ123 altered the responsiveness of renal mechanosensory nerves in CHF...
  39. doi Endothelin receptors A and B are expressed in distinct cellular compartments of rat hippocampus following global ischemia: an immunocytochemical study
    Christian W Kreipke
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurol Res 33:162-8. 2011
    ..Here we characterize endothelin receptor A and endothelin receptor B cellular distribution in hippocampus after permanent global brain ischemia and their possible association to nerve cell injury...
  40. doi Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritis
    Shirine E Usmani
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
    J Orthop Res 30:1391-7. 2012
    ..Expression of ET(A)R protein and its encoding gene Ednra was assessed...
  41. doi Endothelin receptor-mediated responses in trigeminal ganglion neurons
    T Yamamoto
    Division of Physiology, Kokurakitaku, Kitakyushu, Japan
    J Dent Res 92:335-9. 2013
    ..In the present study, we investigated the expression of the endothelin receptors ETA and ETB and endothelin-induced responses in rat TRG neurons...
  42. doi Blockade of endothelin ET(A), but not thromboxane, receptors offsets the cyclosporine-evoked hypertension and interrelated baroreflex and vascular dysfunctions
    Suzanne A Nasser
    Department of Pharmacology, Faculty of Pharmacy, Beirut Arab University, Lebanon
    Eur J Pharmacol 727:52-9. 2014
    ..These effects of CSA were blunted after concurrent i.p. administration of atrasentan (selective ETA blocker, 10mg/kg/day), but not terutroban (thromboxane receptor blocker, 10mg/kg/day)...
  43. doi Endothelin receptor inhibition with bosentan delays onset of liver injury in streptozotocin-induced diabetic condition
    E Demirci
    Department of Pathology, Ataturk University, Faculty of Medicine, Erzurum, Turkey
    Drug Res (Stuttg) 65:272-80. 2015
    This study was designed to investigate the protective effects of bosentan an orally active non-peptide mixed ETA/ETB receptor antagonist, on liver injury in streptozotocin-induced diabetic rats.
  44. doi Angiotensin II enhances endothelin-1-induced vasoconstriction through upregulating endothelin type A receptor
    Yan Jie Lin
    Institute of Physiology, National Yang Ming University, Taipei, Taiwan
    Biochem Biophys Res Commun 451:263-9. 2014
    ..These findings suggest the synergistic effect of Ang II and ET-1 on the pathogenic development of hypertension. ..
  45. doi Endothelin-1 and Endothelin-3 Regulate Endothelin Receptor Expression in Rat Coronary Arteries
    Gry Freja Skovsted
    Department of Clinical Experimental Research, Glostrup Research Institute, Glostrup Hospital, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 117:297-305. 2015
    ..Post-ischaemic and cultured coronary arteries exhibited similar increased sensitivity to ET-3. ETA receptor-mediated vasoconstriction was dominant in fresh and non-ischaemic arteries...
  46. doi Functional ET(A)-ET(B) Receptor Cross-talk in Basilar Artery In Situ From ET(B) Receptor Deficient Rats
    SeongHun Yoon
    Department of Cell Biology and Molecular Medicine, New Jersey Medical School, Rutgers University, Newark, NJ The Department of Pediatric Gastroenterology, The Ohio State University and Nationwide Children s Hospital Columbus, OH International Institute for Integrative Sleep Medicine WPI IIIS, University of Tsukuba, Tsukuba, Japan Department of Neurosurgery, The Neuroscience Institute, University of Cincinnati College of Medicine, Cincinnati, OH and Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH
    J Cardiovasc Pharmacol 67:212-7. 2016
    ..These findings confirm the presence of ET(A)-ET(B) receptor cross-talk in the basilar artery. We speculate that mutant ET(B) receptor expression produced by alternative splicing may be sufficient to allow cross-talk...
  47. doi Endothelin Receptor Down-Regulation Mediated Ligand Regulation Mechanisms Protect Against Cellular Hypoxia Injury in Rat Vascular Endothelial Cells
    Long Li
    Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
    Cell Physiol Biochem 40:1443-1454. 2016
    ..Investigation of the effect of endothelin receptor A (ETaR)-targeting small interfering RNA (siRNA) on rat vascular endothelial cellular hypoxia injury, as well as its underlying mechanism...
  48. ncbi ET(B) receptor-deficient rats exhibit reduced contraction to ET-1 despite an increase in ET(A) receptors
    M G Perry
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912 2500, USA
    Am J Physiol Heart Circ Physiol 281:H2680-6. 2001
    ..Reduced contraction may be related to elevated plasma ET-1 and occurs in the presence of increased ET(A) receptor protein expression, suggesting an uncoupling of ET(A) receptor expression from functional activity...
  49. doi The role of ET(A) and ET(B) receptor antagonists in acute and allergic inflammation in mice
    Candida A L Kassuya
    Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil
    Peptides 29:1329-37. 2008
    ..However, both ET(A) and ET(B) receptor antagonists were found to be effective in inhibiting the allergic response in a murine model of asthma...
  50. doi Endothelin-1 induces organ-specific histamine liberation and neutrophil granulocyte accumulation in the rat
    J Kaszaki
    Institute of Surgical Research, University of Szeged, Pécsi u 4, 6701, Szeged, Hungary
    Inflamm Res 57:396-402. 2008
    ..We compared local consequences of transient increases in circulating ET-1 in three separate circulatory beds in pentobarbital-anesthetized Wistar rats...
  51. doi Testis dysfunction by isoproterenol is mediated by upregulating endothelin receptor A, leptin and protein kinase Cvarepsilon and is attenuated by an endothelin receptor antagonist CPU0213
    Yu Si Cheng
    Research Division of Pharmacology, China Pharmaceutical University, Nanjing 210009, China
    Reprod Toxicol 29:421-6. 2010
    ..Over-expression of ET(A) and leptin accounting for the testis dysfunction is likely to be mediated by pPKCvarepsilon in the ISO treated rats. The upregulated ET pathway appears to be critical in pathologies of the testis...
  52. doi Endothelins as pronociceptive mediators of the rat trigeminal system: role of ETA and ETB receptors
    Juliana Geremias Chichorro
    Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil
    Brain Res 1345:73-83. 2010
    ..Taken together, these findings suggest that endothelins, acting through ET(A) and/or ET(B) receptors, may play an important role in mediating pain resulting from activation of most trigeminal nerve branches...
  53. doi Endothelin receptor A antagonism reduces the extent of diffuse axonal injury in a rodent model of traumatic brain injury
    Christian A Reynolds
    Department of Anatomy and Cell Biology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Neurol Res 33:192-6. 2011
    ..Therefore, this work sought to determine whether treatment with BQ-123, a selective endothelin receptor A antagonist, diminishes the extent of diffuse axonal injury following trauma...
  54. doi Reduced NO production rapidly aggravates renal function through the NF-κB/ET-1/ETA receptor pathway in DOCA-salt-induced hypertensive rats
    Kimihiro Kimura
    Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka, Japan
    Life Sci 91:644-50. 2012
    ..In the present study, we examined the interrelation between ET-1 and NO system using rats treated with the combination of deoxycorticosterone acetate (DOCA)-salt and a non selective NO synthase inhibitor N(ω)-nitro-L-arginine (NOARG)...
  55. pmc Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease
    C E Gariepy
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9050, USA
    J Clin Invest 102:1092-101. 1998
    ..The transgene dosage affects both the incidence and severity of the congenital intestinal defect, suggesting dosage-dependent events downstream of EDNRB activation in ENS development...
  56. ncbi A polymorphism in the endothelin-A receptor gene predicts survival in patients with idiopathic dilated cardiomyopathy
    S Herrmann
    Institute of Clinical Pharmacology and Toxicology, Department of Clinical Pharmacology, Benjamin Franklin Medical Center, Freie Universitat Berlin, Germany
    Eur Heart J 22:1948-53. 2001
    ..We investigated whether genetic polymorphisms of the endothelin system might be associated with dilated cardiomyopathy-related cardiac phenotypes and differences in disease outcome...
  57. ncbi Function and regulation of endothelin-1 and its receptors in salt sensitive hypertension induced by sensory nerve degeneration
    Diana Z Ye
    Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA
    Hypertension 39:673-8. 2002
    ..These results suggest that ET(B) plays an antihypertensive role in response to high salt intake under both normal and sensory nerve degenerated conditions...
  58. ncbi Endothelin receptor blockers reduce I/R-induced intestinal mucosal injury: role of blood flow
    Berna K Oktar
    Department of Physiology, Marmara University School of Medicine, 81326 Haydarpasa, Istanbul, Turkey
    Am J Physiol Gastrointest Liver Physiol 282:G647-55. 2002
    ..Furthermore, ET is involved in the pathogenesis of post-reperfusion-induced damage and beneficial effects of ET receptor antagonism are related to an improvement of disturbed blood flow during the reperfusion period...
  59. ncbi Endothelin receptor function in mesenteric veins from deoxycorticosterone acetate salt-hypertensive rats
    Ronald J Johnson
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    J Hypertens 20:665-76. 2002
    ..To identify the receptors by which endothelin-1 (ET-1) increases venomotor tone in hypertension...
  60. ncbi Endothelin-a receptor in rat skeletal muscle microvasculature
    Debra Mitchell
    Departmente of Pharmacology and Toxicology, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Microvasc Res 64:179-85. 2002
    ..We conclude that the microvasculature of the rat EDL muscle is sensitive to ET-1 and its receptor blockers and that the ET(A) receptor may be present in the capillary wall of this muscle, including the endothelium...
  61. ncbi Endothelin-1 receptor subtypes expression and binding in a perfused rat model of myocardial infarction
    Anwar B Bikhazi
    Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
    Comp Biochem Physiol C Toxicol Pharmacol 134:35-43. 2003
    ..These findings stipulate that during 1 month post-MI some biochemical and hormonal effects could alter ET-1 receptor subtype(s) regulation and pharmacodynamics thus predisposing to cardiac hypertrophy and mitogenesis...
  62. ncbi ETA receptor-mediated Ca2+ mobilisation in H9c2 cardiac cells
    Francesca Ceccarelli
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Italy
    Biochem Pharmacol 65:783-93. 2003
    ..Regulation of channel opening by protein kinase C is also involved in the process of [Ca(2+)](i) increase...
  63. ncbi ETA receptor-mediated Ca2+ signaling in thin descending limbs of Henle's loop: impairment in genetic hypertension
    Matthew A Bailey
    Centre for Nephrology and Department of Physiology, Royal Free and University College Medical School, University College London, UK
    Kidney Int 63:1276-84. 2003
    ....
  64. ncbi Endothelin ET A- and ET B-receptor-mediated inhibition of noradrenaline release from isolated rat stomach
    Kumiko Nakamura
    Department of Pharmacology, Kochi Medical School
    J Pharmacol Sci 91:34-40. 2003
    ....
  65. ncbi Functional endothelin receptors are present on nuclei in cardiac ventricular myocytes
    Benoit Boivin
    Institut de Cardiologie de Montreal, Centre de Recherche, 5000 rue Belanger, Montreal, Quebec H1T 1C8, Canada
    J Biol Chem 278:29153-63. 2003
    ..Hence, cardiac nuclei possess both ETAR and ETBR subtypes, which are functional with respect to ligand binding and are coupled to signaling mechanisms within the nuclear membrane...
  66. ncbi Fibroblast growth factor mediates hypoxia-induced endothelin-- a receptor expression in lung artery smooth muscle cells
    Peng Li
    Department of Medicine, University of Alabama at Birmingham at Alabama, Birmingham, AL 35294, USA
    J Appl Physiol (1985) 95:643-51; discussion 863. 2003
    ....
  67. ncbi Dual constrictor and dilator actions of ET(B) receptors in the rat renal microcirculation: interactions with ET(A) receptors
    Armin Just
    Dept of Cell and Molecular Physiology, 6341 Medical Biomolecular Research Bldg, CB 7545, School of Medicine, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
    Am J Physiol Renal Physiol 286:F660-8. 2004
    ..Possible explanations include ET-1 clearance by ET(B) receptors and/or a dilator ET(B) receptor function that counteracts constriction...
  68. ncbi ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats
    Glaucia E Callera
    Department of Pharmacology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo SP, Brazil
    Hypertension 43:872-9. 2004
    ..We investigated whether ETA receptor blockade modulates in vivo leukocyte-endothelial cell interactions and expression of cell adhesion ..
  69. ncbi Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension
    Masahiro Nishida
    Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
    J Cardiovasc Pharmacol 44:187-91. 2004
    The functional roles of endothelin ETA and ETB receptors in the development of monocrotaline (MCT)-induced pulmonary hypertension were investigated using MCT-treated rats in the absence or presence of a daily administration of A-192621, ..
  70. ncbi Insulin-like growth factor-1 increases endothelin receptor A levels and action in cultured rat aortic smooth muscle cells
    Ching Fai Kwok
    Department of Medicine, Division of Endocrinology and Metabolism, Taipei Veterans General Hospital, Taiwan
    J Cell Biochem 94:1126-34. 2005
    ..These findings support the role of IGF-1 in the development of atherosclerotic, hypertensive, and diabetic vascular complications...
  71. ncbi Altered expression of endothelin and its receptors in the brain of SHR-SP at malignant hypertensive stage
    Subrina Jesmin
    Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    J Cardiovasc Pharmacol 44:S11-5. 2004
    ..Downregulation of the endothelin-B receptor may cause suppression of endothelium-derived relaxing factors in the brain of SHR-SP and be an underlying factor in their stroke susceptibility...
  72. ncbi In vivo imaging of cardiovascular endothelin receptors using the novel radiolabelled antagonist [18F]-SB209670 and positron emission tomography (microPET)
    Peter Johnström
    Clinical Pharmacology Unit, Addenbrooke s Hospital, Cambridge, UK
    J Cardiovasc Pharmacol 44:S34-8. 2004
    ..However, visualization of uptake in the rat heart was achievable and dynamic PET data together with the in vitro results suggest that [F]-SB209670 binds rapidly and primarily to endothelin-A receptors in the heart...
  73. ncbi YM598, an orally active ET(A) receptor antagonist, ameliorates the progression of cardiopulmonary changes and both-side heart failure in rats with cor pulmonale and myocardial infarction
    Akira Fujimori
    Pharmacology Laboratories, Institute for Drug DiscoveryResearch, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Ibaraki, Japan
    J Cardiovasc Pharmacol 44:S354-7. 2004
    The effects of the novel, selective endothelin-A (ETA) receptor antagonist YM598 on both-side heart failure were investigated...
  74. ncbi Effects of ET(A) and ET(B) receptor blockade on post-ischemic cardiac dysfunction and norepinephrine overflow in isolated rat hearts
    Satoshi Yamamoto
    Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
    J Cardiovasc Pharmacol 44:S394-7. 2004
    We investigated the role of endothelin-A (ETA) and endothelin-B (ETB) receptors in ischemia/reperfusion-induced cardiac dysfunction and norepinephrine overflow using isolated rat hearts...
  75. ncbi Renal and systemic effects of chronic blockade of ET(A) or ET(B) receptors in normal rats and animals with experimental heart failure
    Bahaa Francis
    Department of Physiology and Biophysics, and Rappaport Family Institute for Research in Medical Sciences, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    J Cardiovasc Pharmacol 44:S54-8. 2004
    ....
  76. ncbi Effects of endothelin receptor antagonist on expression of AT1 and AT2 receptors in the heart of SHR-SP
    Subrina Jesmin
    Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    J Cardiovasc Pharmacol 44:S59-63. 2004
    ....
  77. ncbi ETA receptor blockade attenuates hypertension and decreases reactive oxygen species in ETB receptor-deficient rats
    Ahmed A Elmarakby
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta 30912 2500, USA
    J Cardiovasc Pharmacol 44:S7-10. 2004
    ..These findings suggest that endothelin-1, through the endothelin-A receptor, contributes to salt-induced hypertension and vascular superoxide production in endothelin-B-deficient rats...
  78. ncbi Blood pressure-independent ETA and AT1 receptor blocker effects on the coronaries of rats harboring human renin and angiotensinogen genes
    Stephan P Gerbaulet
    Franz Volhard Clinic, HELIOS Klinikum Berlin and Max Delbrück Center, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Kidney Blood Press Res 28:134-43. 2005
    ..Blood pressure-independent (BP) effects of angiotensin (Ang) II and endothelin (ET) on coronaries (remodeling) in high renin hypertension are incompletely understood...
  79. ncbi Early endothelin-A receptor blockade decreases blood pressure and ameliorates end-organ damage in homozygous Ren-2 rats
    Ivana Vaneckova
    Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague 4, Czech Republic
    Hypertension 46:969-74. 2005
    We have recently found that nonselective endothelin ETA/ETB receptor blockade markedly improves survival rate and ameliorates end-organ damage in male homozygous rats transgenic (TGR) for the mouse Ren-2 renin gene without lowering blood ..
  80. ncbi Involvement of central endothelin receptors in neonatal morphine withdrawal
    Bhagya L Puppala
    Department of Pediatrics and Neonatology, Advocate Lutheran General Children s Hospital, Park Ridge, Illinois 60068, USA
    Exp Biol Med (Maywood) 231:1157-60. 2006
    ..43%, EC50 = 13.26 nM) and morphine-withdrawal groups (75.08%, EC(50) = 11.70 nM), respectively. To our knowledge, this is the first report indicating involvement of central ET(A) receptors in neonatal morphine withdrawal...
  81. ncbi Cloning and functional identification of novel endothelin receptor type A isoforms in pituitary
    Noriyuki Hatae
    Section on Cellular Signaling, National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Building 49, Room 6A 36, 49 Convent Drive, Bethesda, Maryland 20892 4510, USA
    Mol Endocrinol 21:1192-204. 2007
    ..These results indicate for the first time the presence of a novel ET(A) splice receptor, which could contribute to the functional heterogeneity among secretory pituitary cell types...
  82. ncbi Modulation of the transient outward K+ current by inhibition of endothelin-A receptors in normal and hypertrophied rat hearts
    Michael Wagner
    Institut für Vegetative Physiologie und Pathophysiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Pflugers Arch 454:595-604. 2007
    ....
  83. ncbi Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use
    Muammer Kendirci
    Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Eur Urol 52:555-63. 2007
    ..To evaluate the peripheral mechanisms of erectile dysfunction (ED) in a rat model of triple-binge cocaine administration...
  84. ncbi Effect of delayed cerebral vasospasm on cerebrovascular endothelin A receptor expression and function
    Hartmut Vatter
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurosurg 107:121-7. 2007
    ..Therefore, the aim in the present study was to characterize these alterations, with the emphasis on the ET(A) receptor...
  85. ncbi Evidence for vasculoprotective effects of ETB receptors in resistance artery remodeling in diabetes
    Kamakshi Sachidanandam
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, Georgia, USA
    Diabetes 56:2753-8. 2007
    ..Thus, this study investigated the regulation of MMP activity of resistance arteries under mild-to-moderate diabetes conditions, as seen in type 2 diabetes, and the relative role of ET receptors in this process...
  86. pmc Effect of chronic and selective endothelin receptor antagonism on microvascular function in type 2 diabetes
    Kamakshi Sachidanandam
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Medical College of Georgia, Augusta, Georgia, USA
    Am J Physiol Heart Circ Physiol 294:H2743-9. 2008
    ..Diabetic and control rats received an antagonist to either the ET type A (ETA; atrasentan; 5 mg x kg(-1) x day(-1)) or type B (ET(B); A-192621; 15 or 30 mg x kg(-1) x day(-1)) receptors for 4 ..
  87. doi SB 234551 selective ET(A) receptor antagonism: perfusion/diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection
    Jeffrey J Legos
    High Throughput Biology, Discovery Research, King of Prussia, PA, USA
    Exp Neurol 212:53-62. 2008
    ..In addition, tissue perfusion information obtained under these conditions might clarify mechanism of protection in the evaluation of protective compounds for focal stroke...
  88. pmc ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo
    Tiffany L Thai
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    Am J Physiol Renal Physiol 295:F360-8. 2008
    ..We hypothesized that this signaling pathway is activated by ETA and ETB receptors in the renal vasculature to mediate vasoconstriction in vivo...
  89. doi Age-related changes in endothelin-1 receptor subtypes in rat heart
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Exp Aging Res 34:251-66. 2008
    ..These findings indicate an alteration in ET-1 cardiac receptors associated with aging, mainly due to a variation in the receptor subtype distribution...
  90. doi Endothelin-1 (ET-1) is increased in rat retina after crushing optic nerve
    Hidehiro Oku
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Curr Eye Res 33:611-20. 2008
    ..To determine the alterations in the expression of endothelin-1 (ET-1) and its specific receptors in the sensory retina after optic nerve injury...
  91. pmc Endothelin A receptor blockade influences apoptosis and cellular proliferation in the developing rat kidney
    Kee Hwan Yoo
    Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
    J Korean Med Sci 24:138-45. 2009
    ..Newborn rat pups were treated with either Bristol-Myers Squibb-182874 (30 mg/kg/day), a selective endothelin A receptor (ET(A)R) antagonist, or vehicle for 7 days...
  92. pmc Differential endothelin receptor expression and function in rat myometrial cells and leiomyoma ELT3 cells
    Marie Noëlle Raymond
    Institut de Biochimie et Biophysique Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8619, 91 405 Orsay Cedex, France
    Endocrinology 150:4766-76. 2009
    ..Here we investigated, in ELT3 and myometrial cells, the respective contribution of ETA and ETB in the proliferative effect of ET-1...
  93. pmc Inhibition of endothelin-1 receptors improves impaired nitric oxide synthase-dependent dilation of cerebral arterioles in type-1 diabetic rats
    Denise M Arrick
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5850, USA
    Microcirculation 17:439-46. 2010
    ..The goal of this study was to examine the influence of endothelin-1 receptors (ET(A)) in impaired responses of cerebral (pial) arterioles in type-1 diabetic rats...
  94. pmc Endothelin receptor A-specific stimulation of glomerular inflammation and injury in a streptozotocin-induced rat model of diabetes
    M A Saleh
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30907 2500, USA
    Diabetologia 54:979-88. 2011
    ..Activation of endothelin receptor-A (ET(A)) increases glomerular permeability to albumin (P(alb)) and elevates pro-inflammatory markers in hyperglycaemic rats...
  95. pmc Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor
    H Y Lin
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142
    Proc Natl Acad Sci U S A 88:3185-9. 1991
    ..RNA analysis reveals high expression in rat lung and heart, tissues known to exhibit binding to iodinated endothelin 1...
  96. ncbi Endothelin A and B receptors are down-regulated in the hearts of hypertensive rats
    D J Hayzer
    Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322
    Am J Med Sci 307:222-7. 1994
    ..Conversely, in the brain of spontaneously hypertensive rats, mRNAs for both ET-R(A) and ET-R(B) mRNA were present.(ABSTRACT TRUNCATED AT 250 WORDS)..
  97. ncbi Polymorphisms of the endothelin-A and -B receptor genes in relation to blood pressure and myocardial infarction: the Etude Cas-Témoins sur l'Infarctus du Myocarde (ECTIM) Study
    V Nicaud
    INSERM U258, Paris, France
    Am J Hypertens 12:304-10. 1999
    ..This result will have to be confirmed in other studies...
  98. ncbi Endothelin receptor expression in the normal and injured spinal cord: potential involvement in injury-induced ischemia and gliosis
    Christopher M Peters
    Department of Preventive Science, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 180:1-13. 2003
    ..ETs) are a family of peptides that exert their biological effects via two distinct receptors, the endothelin A receptor (ET(A)R) and the endothelin B receptor (ET(B)R)...
  99. ncbi Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors
    Parviz Afiatpour
    Section of Urology, Yale University School of Medicine, P O Box 208041, New Haven, CT 06520 8041, USA
    Naunyn Schmiedebergs Arch Pharmacol 367:462-72. 2003
    ..This study indicates age-dependent alterations in the ET receptor system at both gene transcript and protein levels in the Fischer rat detrusor...
  100. ncbi ETA and ETB receptor function in pancreatitis-associated microcirculatory failure, inflammation, and parenchymal injury
    T Plusczyk
    Dept of General Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Am J Physiol Gastrointest Liver Physiol 285:G145-53. 2003
    ..taurocholate-induced pancreatitis and intravital microscopy, we therefore studied whether selective inhibition of ETA receptor function or combined ETA and ETB receptor blockade affects the development of pancreatitis-associated ..
  101. ncbi Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries
    Angelica Wackenfors
    Department of Internal Medicine, Division of Experimental Vascular Research, BMC A13, Lund University Hospital, SE 221 84, Lund, Sweden
    Eur J Pharmacol 484:103-9. 2004
    ..The aims were to quantify endothelin type A (ETA) and type B (ETB) receptor mRNA levels in human coronary arteries from patients with ischemic heart disease, ..