Ctnnb1

Summary

Gene Symbol: Ctnnb1
Description: catenin beta 1
Alias: Catnb, catenin beta-1, beta-catenin, catenin (cadherin associated protein), beta 1, 88kDa
Species: rat

Top Publications

  1. pmc Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32
    Mohamed Al-Fageeh
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    Oncogene 23:4839-46. 2004
  2. ncbi Abnormal distribution of E-cadherin and beta-catenin in different histologic types of cancer of the uterine cervix
    Maria Alexandra Rodríguez-Sastre
    Departamento de Biologia Molecular y Biotecnologia, Instituto de Investigaciones Biomedicas UNAM, Mexico D F, Mexico
    Gynecol Oncol 97:330-6. 2005
  3. ncbi Role of beta-catenin in hepatocarcinogenesis of rats
    Qi Ming Wang
    Department of Human Anatomy, Huaxi Medical Centre of Sichuan University, Chengdu 610041, China
    Hepatobiliary Pancreat Dis Int 5:85-9. 2006
  4. pmc BDNF mobilizes synaptic vesicles and enhances synapse formation by disrupting cadherin-beta-catenin interactions
    Shernaz X Bamji
    Neuroscience Program, Howard Hughes Medical Institute, and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 174:289-99. 2006
  5. pmc Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
    Andrew Sunters
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, United Kingdom
    J Biol Chem 285:8743-58. 2010
  6. doi Bcl-2 increases stroke-induced striatal neurogenesis in adult brains by inhibiting BMP-4 function via activation of β-catenin signaling
    Zhi Nian Lei
    Department of Neurobiology and Institute for Biomedical Science, State Key Laboratory of Medical Neurobiology, Shanghai Medical College of Fudan University, Shanghai 200032, PR China
    Neurochem Int 61:34-42. 2012
  7. pmc Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun
    Carmen A Blum
    Linus Pauling Institute, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 6512, USA
    Mol Carcinog 36:195-203. 2003
  8. pmc Inhibiting caspase-3 activity blocks beta-catenin degradation after focal ischemia in rat
    Hanfeng Zhang
    Department of Neurosurgery, Stanford University, Stanford, California 94305 5327, USA
    Neuroreport 19:821-4. 2008
  9. ncbi Interaction of synaptic scaffolding molecule and Beta -catenin
    Wataru Nishimura
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Neurosci 22:757-65. 2002
  10. ncbi Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function
    Sachiko Murase
    Caltech HHMI, Division of Biology, 216 76, 1200 East California Boulevard, Pasadena 91125, USA
    Neuron 35:91-105. 2002

Research Grants

Scientific Experts

Detail Information

Publications137 found, 100 shown here

  1. pmc Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32
    Mohamed Al-Fageeh
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    Oncogene 23:4839-46. 2004
    ..These results are discussed in the context of previous studies, which indicated that amino-acid residue D32 lies within the ubiquitination recognition motif of beta-catenin...
  2. ncbi Abnormal distribution of E-cadherin and beta-catenin in different histologic types of cancer of the uterine cervix
    Maria Alexandra Rodríguez-Sastre
    Departamento de Biologia Molecular y Biotecnologia, Instituto de Investigaciones Biomedicas UNAM, Mexico D F, Mexico
    Gynecol Oncol 97:330-6. 2005
    ..The goal of this study was to analyze the cellular distribution and possible alterations of beta-catenin and E-cadherin proteins in different histologic types of uterine cervical cancer and precursor lesions, compared to normal controls...
  3. ncbi Role of beta-catenin in hepatocarcinogenesis of rats
    Qi Ming Wang
    Department of Human Anatomy, Huaxi Medical Centre of Sichuan University, Chengdu 610041, China
    Hepatobiliary Pancreat Dis Int 5:85-9. 2006
    ..The other takes place in the cytoplasm and nuclei and is thought to regulate cell transformation. We studied the role of beta-catenin in hepatocarcinogenesis of rats...
  4. pmc BDNF mobilizes synaptic vesicles and enhances synapse formation by disrupting cadherin-beta-catenin interactions
    Shernaz X Bamji
    Neuroscience Program, Howard Hughes Medical Institute, and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 174:289-99. 2006
    ..Together, this data demonstrates that the disruption of cadherin-beta-catenin complexes is an important molecular event through which BDNF increases synapse density in cultured hippocampal neurons...
  5. pmc Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
    Andrew Sunters
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, United Kingdom
    J Biol Chem 285:8743-58. 2010
    ..This cascade requires prostanoid/nitric oxide production and is independent of Wnt/LRP5...
  6. doi Bcl-2 increases stroke-induced striatal neurogenesis in adult brains by inhibiting BMP-4 function via activation of β-catenin signaling
    Zhi Nian Lei
    Department of Neurobiology and Institute for Biomedical Science, State Key Laboratory of Medical Neurobiology, Shanghai Medical College of Fudan University, Shanghai 200032, PR China
    Neurochem Int 61:34-42. 2012
    ..These findings highlight a new regulatory mechanism that Bcl-2 elevates ischemia-induced striatal neurogenesis by down-regulating expression of BMP-4 via activation of the Wnt/β-catenin signaling pathway in adult rat brains...
  7. pmc Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun
    Carmen A Blum
    Linus Pauling Institute, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 6512, USA
    Mol Carcinog 36:195-203. 2003
    ..IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (..
  8. pmc Inhibiting caspase-3 activity blocks beta-catenin degradation after focal ischemia in rat
    Hanfeng Zhang
    Department of Neurosurgery, Stanford University, Stanford, California 94305 5327, USA
    Neuroreport 19:821-4. 2008
    ..In conclusion, beta-catenin degraded after stroke, and its degradation was caspase-3 dependent...
  9. ncbi Interaction of synaptic scaffolding molecule and Beta -catenin
    Wataru Nishimura
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Neurosci 22:757-65. 2002
    ..In the presence of overexpressed beta-catenin, the C-terminal region of S-SCAM forms more clusters at synapses. These data suggest that the synaptic targeting of S-SCAM is mediated by the interaction with beta-catenin...
  10. ncbi Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function
    Sachiko Murase
    Caltech HHMI, Division of Biology, 216 76, 1200 East California Boulevard, Pasadena 91125, USA
    Neuron 35:91-105. 2002
    ..Y654F-expressing neurons exhibited a higher minifrequency. Thus, neural activity induces beta-catenin's redistribution into spines, where it interacts with cadherin to influence synaptic size and strength...
  11. ncbi R-cadherin:beta-catenin complex and its association with vascular smooth muscle cell proliferation
    Sadie C Slater
    Bristol Heart Institute, Department of Cardiac, Anesthetic, and Radiological Sciences, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    Arterioscler Thromb Vasc Biol 24:1204-10. 2004
    ..Outside-in signaling from the cadherin:beta-catenin complex can increase transcription of the cell-cycle gene cyclin D1; however, its role in VSMC proliferation has only recently been considered...
  12. ncbi LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses
    Anthone W Dunah
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 8:458-67. 2005
    ..We propose that the cadherin-beta-catenin complex is cotransported with AMPA receptors to synapses and dendritic spines by a mechanism that involves binding of liprin-alpha to LAR-RPTP and tyrosine dephosphorylation by LAR-RPTP...
  13. ncbi Morpholino oligonucleotide-triggered beta-catenin knockdown compromises normal liver regeneration
    Dimple Sodhi
    Department of Pathology, School of Medicine, University of Pittsburgh, S421 BST, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Hepatol 43:132-41. 2005
    ..However, beta-catenin continues to be in hepatocyte nucleus and membrane, secondary to its increased gene expression at 6-72 h...
  14. ncbi Beta-catenin overexpression reduces myocardial infarct size through differential effects on cardiomyocytes and cardiac fibroblasts
    Joo Yong Hahn
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    J Biol Chem 281:30979-89. 2006
    ..beta-Catenin may play an important role in the healing process after MI by promoting survival and cell cycle not only in cardiomyocytes but also in cardiac fibroblasts with its differentiation into myofibroblasts...
  15. pmc beta-Catenin regulates excitatory postsynaptic strength at hippocampal synapses
    Takashi Okuda
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 104:13479-84. 2007
    ..Collectively, these findings suggest that the cadherin-beta-catenin complex is an integral component of synaptic strength regulation and plays a basic role in coupling synapse function and spine morphology...
  16. ncbi Overexpression of E-cadherin and beta-catenin proteins in metastatic prostate cancer cells in bone
    Baisakhi Saha
    Gene Therapy Program, Huntington Medical Research Institutes, Pasadena, California 91101, USA
    Prostate 68:78-84. 2008
    ..The expression of E-cadherin in the intercellular adhesion of metastatic prostate cancer cells in bone, which is the most prevalent site of metastatic growth, remains elusive...
  17. doi Wnt signalling and its impact on development and cancer
    Alexandra Klaus
    Max Delbruck Centre for Molecular Medicine, Robert Roessle Strasse 10, 13, 125 Berlin, Germany
    Nat Rev Cancer 8:387-98. 2008
    ..Since then, further components of the Wnt pathway have been identified and their epistatic relationships have been defined. This article is a Timeline of crucial discoveries about the components and functions of this essential pathway...
  18. pmc Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses
    Michael J Schmeisser
    Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
    J Biol Chem 284:29146-57. 2009
    ..This calls for a novel role of Tcfe2a and c-Myc in plastic changes of neural tissue...
  19. pmc WNT protein-independent constitutive nuclear localization of beta-catenin protein and its low degradation rate in thalamic neurons
    Katarzyna Misztal
    Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, 4 Ks Trojdena Street, 02 109 Warsaw, Poland
    J Biol Chem 286:31781-8. 2011
    ....
  20. ncbi Thyroid hormone interacts with the Wnt/beta-catenin signaling pathway in the terminal differentiation of growth plate chondrocytes
    Lai Wang
    Orthopaedic Research Center, Department of Orthopaedic Surgery, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Bone Miner Res 22:1988-95. 2007
    ..This study indicates that thyroid hormone regulates terminal differentiation of growth plate chondrocytes in part through modulating Wnt/beta-catenin signaling...
  21. pmc Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells
    Annette S Flozak
    Department of Medicine, Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 285:3157-67. 2010
    ....
  22. pmc Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    EMBO J 17:1371-84. 1998
    ..These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin...
  23. pmc Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    J J Lucas
    Centro de Biologia Molecular Severo Ochoa, CSIC Universidad Autonoma de Madrid, Departamento de Morfologia, Facultad de Medicina, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    EMBO J 20:27-39. 2001
    ....
  24. ncbi Glucocorticoids control beta-catenin protein expression and localization through distinct pathways that can be uncoupled by disruption of signaling events required for tight junction formation in rat mammary epithelial tumor cells
    Yi Guan
    Department of Molecular and Cell Biology, 591 LSA, University of California at Berkeley, Berkeley, California 94720 3200, USA
    Mol Endocrinol 18:214-27. 2004
    ....
  25. ncbi Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis
    Wing Yee Lui
    Population Council, Center for Biomedical Research, New York, New York 10021, USA
    J Cell Physiol 202:49-66. 2005
    ..These results illustrate that the interactions among IQGAP1, Cdc42, and beta-catenin are crucial to the regulation of Sertoli-germ cell, but not Sertoli-Sertoli cell, AJ dynamics in the seminiferous epithelium...
  26. ncbi Phospho-beta-catenin accumulation in Alzheimer's disease and in aggresomes attributable to proteasome dysfunction
    Mahin Ghanevati
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Mol Neurosci 25:79-94. 2005
    ..These findings suggest that phospho-beta-catenin accumulation in AD might result from impaired proteasome function...
  27. ncbi Dominant-stable beta-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor model
    Derek Boerboom
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 66:1964-73. 2006
    ..that misregulated Wnt/beta-catenin signaling occurs in ovarian granulosa cell tumors (GCT) and have created the Catnb(flox(ex3)/+);Amhr2(cre/+) mouse model, which expresses a dominant-stable mutant of beta-catenin in granulosa cells ..
  28. pmc The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway
    Hui Jye Chen
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Genes Dev 20:1933-45. 2006
    ..These results suggest a new role of MACF1 in the Wnt signaling pathway...
  29. ncbi Development of leiomyosarcoma of the uterus in MMTV-CR-1 transgenic mice
    L Strizzi
    Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
    J Pathol 211:36-44. 2007
    ....
  30. ncbi [Prognostic value of E-cadherina, beta catenin, Ki-67 antigen and p53 protein in the superficial bladder tumors]
    J L Moyano Calvo
    Servicio de Urologia, Hospital Virgen Macarena, Sevilla
    Actas Urol Esp 30:871-8. 2006
    ..We are going to investigate the capacity of prediction for tumor recurrence of protein p53, antigen Ki-67, E Cadherin and Beta Catenin
  31. ncbi Expression pattern of adhesion molecules (E-cadherin, alpha-, beta-, gamma-catenin and claudin-7), their influence on survival in primary breast carcinoma, and their corresponding axillary lymph node metastasis
    Daehoon Park
    Department of Pathology, Ullevaal University Hospital, Oslo, Norway
    APMIS 115:52-65. 2007
    ....
  32. ncbi Immunohistochemical expression of PTEN and beta-catenin for endometrial intraepithelial neoplasia in Japanese women
    Yoshiaki Norimatsu
    Department of Pathology, Kurashiki Central Hospital, Kurashiki, Okayama 710 8672, Japan
    Ann Diagn Pathol 11:103-8. 2007
    ..The combination of PTEN-negative/beta-catenin-positive results may become the reliable marker for detecting EIN...
  33. ncbi Involvement of mutation-based inhibition of beta-catenin phosphorylation at Ser33 in the malignant progression of lung (pre)neoplastic lesions induced by N-nitrosobis(2-hydroxypropyl)amine in male Fischer 344 rats
    Maki Igarashi
    Laboratory of Protection of Body Function, Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya, Tokyo, 156 0054, Japan
    Lung 185:271-8. 2007
    ..These phenomena might contribute to the malignant progression of the lung (pre)neoplastic lesions, which start from the relatively early stage in lung carcinogenesis...
  34. pmc Nuclear accumulation of beta-catenin protein indicates activation of wnt signaling in chemically induced rat nephroblastomas
    David Ehrlich
    Division of Applied Tumor Biology, Institute of Pathology, University Hospital of Heidelberg, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
    Pediatr Dev Pathol 13:1-8. 2010
    Aberrant wnt signaling caused by mutations in CTNNB1 occurs in about 15% of Wilms tumors, and these mutations appear to be dependent on the concomitant mutational inactivation of the zinc-finger protein WT1...
  35. pmc Cytoplasmic polyadenylation element-binding protein regulates neurotrophin-3-dependent beta-catenin mRNA translation in developing hippocampal neurons
    Mitchell Kundel
    Department of Cell Biology, Yale University, New Haven, Connecticut 06520 8103, USA
    J Neurosci 29:13630-9. 2009
    ..Together, these results suggest that CPEB1 regulates beta-catenin synthesis in neurons and may contribute to neuronal morphogenesis...
  36. doi Neonatal growth and regeneration of beta-cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats
    Florence Figeac
    University Paris Diderot Centre National de la Recherche Scientifique Equipe d Accueil Conventionnée 4413, Laboratory of Biology and Pathology of the Endocrine Pancreas, Paris, France
    Am J Physiol Endocrinol Metab 298:E245-56. 2010
    ..These findings might have potential clinical applications in the regenerative therapy of diabetes...
  37. pmc A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/beta-catenin signaling
    Jin Ran Chen
    Arkansas Children s Nutrition Center, 15 Children s Way, Little Rock, AR 72202, USA
    J Bone Miner Res 25:1117-27. 2010
    ..These observations are consistent with the hypothesis that ethanol inhibits bone formation through stimulation of oxidative stress to suppress Wnt signaling...
  38. pmc Assessing the role of the cadherin/catenin complex at the Schwann cell-axon interface and in the initiation of myelination
    Kathryn A Lewallen
    Department of Biochemistry and Molecular Biology, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Neurosci 31:3032-43. 2011
    ..Together, our results suggest that N-cadherin interacts with β-catenin in establishing SC polarity and the timely initiation of myelination, but they are nonessential components for the formation and maturation of the myelin sheath...
  39. ncbi [Effect of subchronic fluoride exposure on pathologic change and beta-catenin expression in rat bone tissue]
    Xiaoying Guo
    Department of Biogeochemical Disease, Liaoning Provincial Key Laboratory of Arsenic Biological Effect, China Medical University, Shenyang, China
    Wei Sheng Yan Jiu 40:304-7. 2011
    ..To explore the effect of subchronic fluoride exposure on the expression of beta-catenin in the bone of rats and the role of beta-catenin in skeletal damage...
  40. pmc miR-145 is differentially regulated by TGF-β1 and ischaemia and targets Disabled-2 expression and wnt/β-catenin activity
    Maritza E Mayorga
    Skirball Laboratory for Cardiovascular Cellular Therapeutics, Cleveland, OH, USA
    J Cell Mol Med 16:1106-13. 2012
    ..Our data demonstrate a novel and critical role for miR-145 expression as a regulator of Dab2 expression and β-catenin activity in response to TGF-β(1) and hypoxia...
  41. doi Gone with the Wnt: the canonical Wnt signaling axis is present and androgen dependent in the rodent gubernaculum
    Nan Chen
    Murdoch Children s Research Institute, Melbourne, Australia
    J Pediatr Surg 46:2363-9. 2011
    ..The relationship between β-catenin and androgen receptor warranted investigation into the involvement of the canonical Wnt pathway in testicular descent...
  42. pmc WISP1 (CCN4) autoregulates its expression and nuclear trafficking of β-catenin during oxidant stress with limited effects upon neuronal autophagy
    Shaohui Wang
    Laboratory of Cellular and Molecular Signaling, Cancer Center, F 1220, New Jersey Health Sciences University, 205 South Orange Avenue, Newark, NJ 07101, USA
    Curr Neurovasc Res 9:91-101. 2012
    ..New strategies that target WISP1, its autoregulation, and the pathways responsible for neuronal cell injury may bring forth new insight for the treatment of neurodegenerative disorders...
  43. ncbi [Expression of beta-catenin in articular cartilage of knee primary osteoarthritis]
    Xiaomin Fang
    Medicine School ofNingxia Medical University, Yinchuan Ningxia 750004, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 26:532-5. 2012
    ..To investigate the role of beta-catenin in pathogenesis and progression of knee primary osteoarthritis (OA) by detecting the expression of beta-catenin...
  44. pmc Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin
    Angelo Pietro Femia
    Department of Pharmacology, University of Florence, 6 Viale Pieraccini, 50139, Florence, Italy
    BMC Cancer 13:48. 2013
    ..Although many markers for these cells have been proposed, there is no complete agreement regarding them, nor has their presence in the early phases of carcinogenesis been characterized in depth...
  45. doi Morin ameliorates chemically induced liver fibrosis in vivo and inhibits stellate cell proliferation in vitro by suppressing Wnt/β-catenin signaling
    Perumal Madankumar
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India
    Toxicol Appl Pharmacol 277:210-20. 2014
    ..Hence morin could be employed as a promising chemopreventive natural supplement for liver fibrosis...
  46. doi High phosphorus level leads to aortic calcification via β-catenin in chronic kidney disease
    Li Yao
    Department of Nephrology, The First Hospital of China Medical University, Shenyang, Liaoning, China
    Am J Nephrol 41:28-36. 2015
    ..Vascular calcification is a risk factor for causing cardiovascular events and has a high prevalence among chronic kidney disease (CKD) patients. However, the molecular mechanism underlying this pathogenic process is still obscure...
  47. doi Impact and significance of EGCG on Smad, ERK, and β-catenin pathways in transdifferentiation of renal tubular epithelial cells
    C G Zhao
    Department of Pediatric Nephrology and Rheumatology, Shengjing Hospital of China Medical University, Shenyang, China
    Genet Mol Res 14:2551-60. 2015
    ..EGCG may be helpful for maintaining the renal tubular epithelial cell phenotype and reducing the degree of TGF-b1- induced cell transdifferentiation, which may be related to the signal transduction pathway of ERK, Smad3, and β-catenin...
  48. pmc Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552
    Jia Wang
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, Los Angeles, California
    Am J Physiol Cell Physiol 310:C542-57. 2016
    ..Collectively, our results identify a novel cross talk between PKD and β-catenin in intestinal epithelial cells, both in vitro and in vivo...
  49. pmc p300/β-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC)
    Megan E Rieger
    From the Department of Medicine, Will Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine
    J Biol Chem 291:6569-82. 2016
    ....
  50. pmc Activation of Wnt/beta-catenin signaling increases insulin sensitivity through a reciprocal regulation of Wnt10b and SREBP-1c in skeletal muscle cells
    Mounira Abiola
    Genetics and Development Department, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    PLoS ONE 4:e8509. 2009
    ..As recent studies point towards a role for Wnt signaling in the pathogenesis of type 2 diabetes, we hypothesized that activation of Wnt signaling could play a crucial role in muscle insulin sensitivity...
  51. pmc Transglutaminase 2-mediated activation of β-catenin signaling has a critical role in warfarin-induced vascular calcification
    Kelly E Beazley
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N Greene St, Baltimore, MD 21201, USA
    Arterioscler Thromb Vasc Biol 32:123-30. 2012
    ..Here we investigated the role of the TG2/β-catenin signaling axis in vascular calcification induced by warfarin...
  52. pmc GSK-3β suppresses the proliferation of rat hepatic oval cells through modulating Wnt/β-catenin signaling pathway
    Xiao ke Ji
    Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
    Acta Pharmacol Sin 36:334-42. 2015
    ..In this study we investigated the role of GSK-3β in regulation of growth of hepatic oval cells in vitro and in liver regeneration in partially hepatectomized rats...
  53. pmc Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells
    Joseph C Lim
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    J Neurochem 106:1855-65. 2008
    ..These results suggest that regulation of p-gp and other multidrug efflux transporters in brain vasculature can be influenced by beta-catenin signalling...
  54. pmc Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex
    Yan Chun Li
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 29:15551-63. 2009
    ....
  55. pmc Delta-catenin/NPRAP: A new member of the glycogen synthase kinase-3beta signaling complex that promotes beta-catenin turnover in neurons
    Sonja Bareiss
    Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    J Neurosci Res 88:2350-63. 2010
    ....
  56. pmc Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    PLoS ONE 6:e23914. 2011
    ..Since activation of Wnt/β-catenin signaling has been suggested to be central to mechanisms of lung healing and fibrosis, we hypothesized that the Wnt/β-catenin signaling plays a role during VILI...
  57. doi β-Catenin dynamics in the regulation of microvascular endothelial cell hyperpermeability
    Binu Tharakan
    Department of Surgery, Texas A and M Health Science Center College of Medicine and Scott and White Memorial Hospital, Temple, Texas 76508, USA
    Shock 37:306-11. 2012
    ..Our data suggest a recycling pathway for β-catenin to the cell junction...
  58. doi MiR-200a is involved in rat epididymal development by targeting β-catenin mRNA
    Xiaojiang Wu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Acta Biochim Biophys Sin (Shanghai) 44:233-40. 2012
    ..All these results show that miR-200a should be involved in rat epididymal development by targeting β-catenin mRNA of rat and suppressing its expression...
  59. doi Treadmill training regulates β-catenin signaling through phosphorylation of GSK-3β in lumbar vertebrae of ovariectomized rats
    Shumin Bu
    Capital University of Physical Education and Sport, 11 Beisanhuanxilu, Haidian District, Beijing, 100191, People s Republic of China
    Eur J Appl Physiol 112:3295-304. 2012
    ....
  60. doi The effect of citalopram on chronic stress-induced depressive-like behavior in rats through GSK3β/β-catenin activation in the medial prefrontal cortex
    Y C Chen
    Department of Psychosomatics, Xi Jing Hospital, Fourth Military Medical University, Xi an, PR China
    Brain Res Bull 88:338-44. 2012
    ....
  61. doi Characterization of Wnt2 overexpression in a rat granulosa cell line (DC3): effects on CTNNB1 activation
    Kenneth W Finnson
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
    Biol Reprod 87:12, 1-8. 2012
    ..results demonstrate that Wnt2 overexpression in DC3 promotes cytosolic and nuclear accumulation of beta-catenin (CTNNB1), but does not stimulate CTNNB1/TCF-dependent (pGL3-OT) transcriptional activity...
  62. doi Identification of a pathway by which glucose regulates β-catenin signalling via the cAMP/protein kinase A pathway in β-cell models
    Emmanuelle Cognard
    Department of Molecular Medicine and Pathology, Faculty of Medicine and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Biochem J 449:803-11. 2013
    ..This identifies a pathway that may be important in glucose-dependent regulation of gene expression and insulin secretion in β-cells...
  63. pmc Axonal translation of β-catenin regulates synaptic vesicle dynamics
    Anne Marion Taylor
    University of North Carolina at Chapel Hill, Joint Department of Biomedical Engineering, Chapel Hill, North Carolina 27599, USA
    J Neurosci 33:5584-9. 2013
    ..Thus, local translation of β-catenin is a newly described mechanism for axons to independently functionalize nerve terminals at great distances from cellular somata...
  64. ncbi N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes
    C M Hertig
    Institute for Cell Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Cell Sci 109:11-20. 1996
    ....
  65. pmc Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos
    H Yamamoto
    Department of Biochemistry, Hiroshima University School of Medicine, Japan
    Mol Cell Biol 18:2867-75. 1998
    ..These results indicate that Axil negatively regulates the Wnt signaling pathway by mediating GSK-3beta-dependent phosphorylation of beta-catenin, thereby inhibiting axis formation...
  66. ncbi Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase
    Y T Kwon
    Health Advances, Inc, Wellesley, Massachusetts 02181, USA
    Curr Biol 10:363-72. 2000
    ..In p35(-/-) mice, embryonic cortical neurons are unable to migrate past their predecessors, leading to an inversion of cortical layers in the adult cortex...
  67. ncbi A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation
    I Sakamoto
    Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, PRESTO, Japan
    J Biol Chem 275:32871-8. 2000
    ..Thus, Duplin is a nuclear protein that inhibits beta-catenin signaling...
  68. ncbi [Beta-catenin and its mRNA in renal cell carcinoma]
    T Zang
    Institute of Urology, Beijing Medcal University, Beijing 100034, China
    Zhonghua Wai Ke Za Zhi 38:37-9. 2000
    ..To investigate the role of beta-catenin in renal cell carcinoma...
  69. ncbi Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline
    Qingjie Li
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    Gene 283:255-62. 2002
    ..The primary sequence of the human beta-catenin gene (CTNNB1) has been known for some time, but that of the rat beta-catenin gene (Ctnnb1) has not heretofore been studied in ..
  70. ncbi Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling
    Takatoshi Karasawa
    Child Study Center and Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 277:37479-86. 2002
    ..Rfz9 also relocalizes Axin from the cytoplasm to the plasma membrane in the presence of Dvl-1, suggesting that one of the consequences of Dvl-1 relocalization by Rfz9 is to bring Axin to the cell membrane...
  71. ncbi Codon 45 of the beta-catenin gene, a specific mutational target site of Wilms' tumor
    Takeshi Kusafuka
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Mol Med 10:395-9. 2002
    ....
  72. ncbi Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis?
    Nikki P Y Lee
    Population Council, Center for Biomedical Research, New York, New York 10021, USA
    Biol Reprod 68:489-508. 2003
    ..These results thus unequivocally demonstrate that the cadherin/catenin complex, which can be up-regulated by testosterone, is indeed present between Sertoli and germ cells and is used for the assembly of functional AJs...
  73. ncbi Altered adhesion features and signal transduction in NRK-49F cells transformed by down-regulation of lysyl oxidase
    Monia Giampuzzi
    Laboratorio di Nefrologia, Istituto G Gaslini, Largo G Gaslini, 5, 16147 Genova, Italy
    Biochim Biophys Acta 1647:239-44. 2003
    ..We believe that the resulting up-regulation of cyclin D1 acted in synergy with ras to induce the cell transformation...
  74. ncbi Beta-catenin/Tcf activation partially mimics the transforming activity of Wnt-1 in Rat-1 fibroblasts
    C S Young
    Department of Pathology and OB GYN, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Differentiation 71:477-85. 2003
    ..As ectopic expression of beta-cateninS37A only partially mimics Wnt-1 effects on Rat-1 cells, we conclude that Wnt-1 signaling elicits biochemical events that act in addition to beta-catenin/Tcf signaling to promote cell growth...
  75. ncbi Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin
    Sung Il Kim
    Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500 712, Republic of Korea
    Biochem Biophys Res Commun 317:478-83. 2004
    ..This suggests that cyclin A/CDK2 is a negative regulator of beta-catenin-mediated signal transduction, which exerts its effects through phosphorylation of Axin...
  76. ncbi Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells
    Reshma Rangwala
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Biol Chem 280:11790-7. 2005
    ..Collectively, these data indicate that erbin regulates MAP kinase activation in Schwann cells and suggest that erbin links merlin to both adherens junction protein complexes and the MAP kinase signaling pathway...
  77. ncbi Regulation of the versican promoter by the beta-catenin-T-cell factor complex in vascular smooth muscle cells
    Maziar Rahmani
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    J Biol Chem 280:13019-28. 2005
    ....
  78. pmc Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells
    Jessica A Gorski
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Mol Biol Cell 16:3574-90. 2005
    ..This neuronal regulation of AKAP79/150 targeting to cadherins may be important in functional and structural synaptic modifications underlying plasticity...
  79. ncbi beta-Catenin regulation during matrigel-induced rat hepatocyte differentiation
    Satdarshan P S Monga
    Department of Pathology, School of Medicine, University of Pittsburgh, PA, 15261, USA
    Cell Tissue Res 323:71-9. 2006
    ..Thus, beta-catenin undergoes multifactorial regulation during matrigel-induced hepatocyte differentiation and maturation; this induces its stabilization and membrane translocation, possibly contributing to hepatocyte differentiation...
  80. ncbi Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome
    Marisa Dolled-Filhart
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 66:5487-94. 2006
    ..These results suggest that loss of beta-catenin expression at the membrane, as assessed by objective quantitative analysis methods, may be useful as a prognostic marker or may be part of a useful algorithm for prognosis in breast cancer...
  81. ncbi G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin
    Maria V Abramova
    Institute of Cytology, Russian Academy of Sciences, St Petersburg
    J Biol Chem 281:21040-51. 2006
    ....
  82. ncbi Distribution of E-cadherin and beta-catenin in relation to cell maturation and cell extrusion in rat and mouse small intestines
    Lars Inge Larsson
    Anatomy and Cell Biology, IBHV, KVL, Gronnegaardsvej 7, 1870 Frederiksberg C, Copenhagen, Denmark
    Histochem Cell Biol 126:575-82. 2006
    ..Therefore, these results suggest that loss of beta-catenin precedes the onset of programmed cell death, loss of E-cadherin and extrusion from the villi...
  83. ncbi Reduced expression level of mgmt mRNA and beta-catenin gene mutation in rat colon tumors
    Tatsuya Kinjo
    Tumor Pathology, University of the Ryukyus Faculty of Medicine, Okinawa 903 0215, Japan
    Anticancer Res 26:2829-32. 2006
    ..The purpose of this study was to investigate the association between the mRNA expression level of the Mgmt gene and mutation of the beta-catenin gene in rat colon tumors induced by azoxymethane (AOM) plus dextran sulfate sodium (DSS)...
  84. ncbi [Beta-catenin expression in intestinal mucosa of rats with severe abdominal infection]
    Jin feng Liu
    Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1733-5. 2006
    ..To investigate the expression of beta-catenin in the intestinal mucosa of rats with severe abdominal infection...
  85. ncbi Activation of beta-catenin in the stem cell region of crypts during growth of the small intestine in infant rats
    Kimberley S Camac
    Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, Woodville South, Australia
    Dig Dis Sci 52:1242-6. 2007
    ..Tcf-4 nuclear expression peaked earlier at 7 days and was lower thereafter with age. We conclude that the Wnt/beta-catenin pathway is activated in the stem cell region of intestinal crypts during growth of the small intestine...
  86. pmc Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1
    Q Li
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Oncogene 26:6194-202. 2007
    ..These findings suggest an indirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc and E2F1...
  87. ncbi Significance of inflammation-associated regenerative mucosa characterized by Paneth cell metaplasia and beta-catenin accumulation for the onset of colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine
    Toshio Imai
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Carcinogenesis 28:2199-206. 2007
    ....
  88. ncbi Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation
    Aino Kuorelahti
    Department of Physiology, Institute of Biomedicine, and Turku Graduate School of Biomedical Sciences, University of Turku, 20520 Turku, Finland
    Endocrinology 148:3694-703. 2007
    ..The novel finding of hCG up-regulating wnt7b and wnt5b could contribute to pregnancy-induced breast cancer in humans...
  89. ncbi Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Cancer Res 67:6925-35. 2007
    ..Our results indicate that apigenin effectively suppressed prostate carcinogenesis in TRAMP mice, at least in part, by blocking beta-catenin signaling...
  90. ncbi Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats
    Hang Xiao
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Carcinogenesis 29:113-9. 2008
    ..Taken together, our results strongly suggest the colon cancer-preventive activity of PPE and identified possible molecular markers for future colon cancer prevention studies...
  91. pmc Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway
    Yu Ting Liu
    Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Am J Pathol 171:1978-88. 2007
    ..Thus, iron-mediated persistent oxidative stress confers an environment for gene amplification...
  92. pmc Hypothermia blocks beta-catenin degradation after focal ischemia in rats
    Hanfeng Zhang
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305 5327, USA
    Brain Res 1198:182-7. 2008
    ..In conclusion, moderate hypothermia can stabilize beta-catenin, which may contribute to the protective effect of moderate hypothermia...
  93. pmc VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability
    Mingzhang Guo
    Department of Surgery, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    Am J Physiol Cell Physiol 294:C977-84. 2008
    ..Taken together, these data suggest that inflammatory agents like histamine cause a transient and reversible disruption of binding between beta-catenin and VE-cadherin, during which endothelial permeability is elevated...
  94. pmc Phosphorylation of beta-catenin by PKA promotes ATP-induced proliferation of vascular smooth muscle cells
    Sebastien Taurin
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Cell Physiol 294:C1169-74. 2008
    ..In conclusion, we show a novel mode of regulation of endogenous beta-catenin through its phosphorylation by PKA, and we demonstrate the importance of this mechanism for ATP-induced proliferation of VSMC...
  95. pmc Differential modulation of Akt/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responses
    Venugopalan D Nair
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Biol Chem 283:15469-78. 2008
    ..Inhibition of GSK-3beta activity by inhibitor VIII protects cells from H2O2 similar to ropinirole. These results indicate that GSK-3beta downstream of Akt plays a critical role in cell death and survival in these models...
  96. doi Signalling by neurotrophins and hepatocyte growth factor regulates axon morphogenesis by differential beta-catenin phosphorylation
    Monica D David
    Laboratori d Investigacio, Hospital Universitari Arnau de Vilanova, Departament de Ciencies Mediques Basiques, Universitat de Lleida, IRBLLEIDA, Spain
    J Cell Sci 121:2718-30. 2008
    ..These results place beta-catenin downstream of growth-factor-RTK signalling in axon differentiation...
  97. pmc Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin
    Seung Hye Lee
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 183:893-908. 2008
    ..Our results indicate that a presynaptic signaling pathway through p120ctn, Fer, SHP-2, and beta-catenin promotes excitatory synapse development and function...
  98. doi Expression and tissue localization of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 is modulated during rat and human left ventricular hypertrophy
    Heidrun Ridinger
    RZPD German Resource Center for Genome Research, 69120 Heidelberg, Germany
    Exp Mol Pathol 86:23-31. 2009
    ..Our results show that the parallel investigation of rat and human cardiac tissue as well as human cellular models in vitro represents a promising strategy to identify reliable biomarkers of LVH...
  99. doi The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3
    Roman Kessler
    Institut fur Molekularbiologie, Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Mech Dev 126:752-9. 2009
    ..Our results reveal an interesting evolutionary dichotomy in Pygo structure-function, as well as evidence underpinning the chain of adaptors model...
  100. pmc Pleiotrophin regulates lung epithelial cell proliferation and differentiation during fetal lung development via beta-catenin and Dlk1
    Tingting Weng
    Lundberg Kienlen Lung Biology and Toxicology Laboratory, Department of Physiological Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    J Biol Chem 284:28021-32. 2009
    ..These results provide evidence that pleiotrophin regulates fetal type II cell proliferation and differentiation via integration of multiple signaling pathways including pleiotrophin, beta-catenin, and Notch pathways...
  101. pmc Identification of functional marker proteins in the mammalian growth cone
    Motohiro Nozumi
    Divisions of Molecular Cell Biology and Ophthalmology, Niigata University, 1 757 Asahi machi, Chuo Ku, Niigata, Niigata 951 8510, Japan
    Proc Natl Acad Sci U S A 106:17211-6. 2009
    ..Most of the proteins we identified have not previously been implicated in axon growth and thus their identification presents a significant step forward, providing marker proteins and candidate neuronal growth-associated proteins...

Research Grants1

  1. HORMONAL REGULATION OF LUNG DEVELOPMENT; PTHrP BIOLOGY
    John Torday; Fiscal Year: 2009
    ..These studies will provide important insights to the pathophysiology and treatment of chronic lung diseases of the newborn and adult alike. ..