Genomes and Genes
Gene Symbol: Crhr2
Description: corticotropin releasing hormone receptor 2
Alias: CRF-R 2, CRH-R 2, Crf2r, corticotropin-releasing factor receptor 2, CRF-R-2, CRF-R2, CRF2, CRFR-2, CRH-R-2, CRH-R2, corticotrophin releasing hormone receptor 2, corticotropin-releasing factor receptor subtype 2
- Differential role of corticotrophin-releasing factor receptor types 1 and 2 in stress-induced suppression of pulsatile luteinising hormone secretion in the female ratX F Li
Division of Reproductive Health, Endocrinology and Development, King s College London, Guy s Campus, London, UK
J Neuroendocrinol 18:602-10. 2006..These results suggest that hypoglycaemia and LPS stress-induced LH suppression involves activation of CRF(2) while restraint stress-induced inhibition of LH pulses involves both CRF(1) and CRF(2)...
- Activation of the CRF 2 receptor modulates skeletal muscle mass under physiological and pathological conditionsRichard T Hinkle
Research Division, Procter and Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040 9317, USA
Am J Physiol Endocrinol Metab 285:E889-98. 2003..factor (CRF) family of peptides have been identified, the CRF 1 receptor (CRF1R) and the CRF 2 receptor (CRF2R). Of these, the CRF2R is expressed in skeletal muscle...
- CRF binding protein facilitates the presence of CRF type 2α receptor on the cell surfacePaula G Slater
Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, 8331150 Santiago, Chile
Proc Natl Acad Sci U S A 113:4075-80. 2016..There is evidence that CRF-BP potentiates CRF and urocortin 1 actions through CRF type 2 receptors (CRF2R). CRF2R is a G protein-coupled receptor (GPCR) that is found mainly intracellularly as most GPCRs...
- Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasisChien Li
The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 104:4206-11. 2007....
- Activation of the nociceptin/orphanin FQ system is unable to reverse CRF2 receptor mediated anorexia in the ratAmalia Fedeli
Department of Experimental Medicine and Public Health, University of Camerino, Via Scalzino 3, 62032 Camerino MC, Italy
Peptides 27:3284-91. 2006..Conversely, injection of N/OFQ (0.25-2.0 nmol/rat) blocked the anorectic effect of CRF (0.1 nmol/rat). These findings suggest that N/OFQ selectively prevent the anorectic effect mediated by activation of the CRF(1) receptor system...
- Urocortin prevents indomethacin-induced small intestinal lesions in rats through activation of CRF2 receptorsYoshikazu Kubo
Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Yamashina, Kyoto, Japan
Dig Dis Sci 55:1570-80. 2010..The role of corticotropin-releasing factor (CRF) in the pathogenesis of indomethacin-induced small intestinal lesions was examined in rats...
- Corticotrophin-releasing factor alters the timing of puberty in the female ratJ S Kinsey-Jones
Division of Reproduction and Endocrinology, King s College London, Guy s Campus, London, UK
J Neuroendocrinol 22:102-9. 2010..In the PVN, expression of CRF, but not CRF-R1 mRNA, was reduced at the time of puberty. These data support the hypothesis that CRF signalling may play an important role in modulating the timing of puberty in the rat...
- Chronic amphetamine treatment enhances corticotropin-releasing factor-induced serotonin release in the amygdalaJamie L Scholl
Division of Basic Biomedical Sciences and Neuroscience Group, Sanford School of Medicine, University of South Dakota, 414 E Clark St Vermillion, SD, USA
Eur J Pharmacol 644:80-7. 2010..These results suggest increased sensitivity to corticotropin-releasing factor as mediated by type-2 receptors following chronic amphetamine treatment, which may underlie dysphoric states observed during amphetamine withdrawal...
- Neuroanatomical evidence for reciprocal regulation of the corticotrophin-releasing factor and oxytocin systems in the hypothalamus and the bed nucleus of the stria terminalis of the rat: Implications for balancing stress and affectJoanna Dabrowska
Center for Translational Social Neuroscience, Yerkes National Primate Research Center, Department of Psychiatry and Behavioral Sciences, Emory University, 954 Gatewood Rd, Atlanta, GA 30329, USA
Psychoneuroendocrinology 36:1312-26. 2011..Previous studies have reported that mRNA for CRF2 receptor (CRFR2) is expressed in the bed nucleus of the stria terminalis (BNST) as well as hypothalamic nuclei, but ..
- Peripheral corticotropin-releasing factor (CRF) induces stimulation of gastric contractions in freely moving conscious rats: role of CRF receptor types 1 and 2T Nozu
Department of Regional Medicine and Education, Asahikawa Medical University, Asahikawa, Japan
Neurogastroenterol Motil 25:190-7. 2013..CRF injected peripherally inhibits gastric emptying, but its effect on gastric contractions has not been clarified in freely moving conscious rats...
- The effects of vasoactive peptide urocortin 2 on hemodynamics in spontaneous hypertensive rat and the role of L-type calcium channel and CRFR2Chunna Liu
Department of Pharmacology, Liaoning Medical University, Jinzhou, China Electronic address
Pharmacol Rep 67:394-8. 2015..The effects and mechanism of urocortin 2 (UCN2) in vivo on the electrical remodeling of left ventricle and the hemodynamics of hypertensive objectives have not been investigated...
- Effects of dorsal periaqueductal gray CRF1- and CRF2-receptor stimulation in animal models of panicThatiane de Oliveira Sergio
Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
Psychoneuroendocrinology 49:321-30. 2014..Controversial results have been obtained regarding the involvement of CRF1 and CRF2 receptors in the regulation of panic-related responses. We report here that CRF (0...
- Estrogens protect myocardium against ischemia/reperfusion insult by up-regulation of CRH receptor type 2 in female ratsBinhai Cong
Department of Physiology and The Key Laboratory of Molecular Neurobiology of Ministry of Education, Second Military Medical University, Shanghai 200433, PR China
Int J Cardiol 168:4755-60. 2013..The goal of present study is to investigate whether estrogens regulate UCN and its receptor CRH receptor type 2 (CRHR2) in female rat heart.
- Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesisNina C Donner
Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, 1725 Pleasant Street, 114 Clare Small, UCB 354, 80309 Boulder, CO, USA Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany Electronic address
Psychoneuroendocrinology 63:178-90. 2016..the DR, and pharmacologically blocked either corticotropin-releasing hormone receptor type 1 (CRHR1) or type 2 (CRHR2) 10 min prior to acoustic startle stress...
- Noise Stress-Induced Changes in mRNA Levels of Corticotropin-Releasing Hormone Family Molecules and Glucocorticoid Receptors in the Rat BrainE Eraslan
Department of Physiology, Faculty of Veterinary Medicine, Istanbul University, Istanbul, Turkey
Folia Biol (Praha) 61:66-73. 2015....
- Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodentsGuillaume Gourcerol
Center for Ulcer Research and Education Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
Gastroenterology 140:1586-96.e6. 2011..Corticotropin-releasing factor receptor-1 (CRF(1)) mediates the stress-induced colonic motor activity. Less is known about the role of CRF(2) in the colonic response to stress...
- The effect of CRF2 receptor antagonists on rat conditioned fear responses and c-Fos and CRF expression in the brain limbic structuresA Skorzewska
Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957 Warsaw, Poland
Behav Brain Res 221:155-65. 2011..These data support a model in which an excess in CRF(1) receptor activation, combined with reduced CRF(2) receptor signaling, may contribute to stronger expression of anxiety-like responses...
- Expression of urocortin and its receptors in the rat epididymisAdriana De Luca
Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via Veterinaria 1, I 80137 Naples, Italy Electronic address
Reprod Biol 14:140-7. 2014..are mediated by two types of G-protein-coupled receptors, CRH type 1 receptor (CRHR1) and CRH type 2 receptor (CRHR2)...
- Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stressE M Fekete
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Br J Pharmacol 164:1959-75. 2011..Infusion of corticotropin-releasing factor (CRF)/urocortin (Ucn) family peptides suppresses feeding in mice. We examined whether rats show peripheral CRF/Ucn-induced anorexia and determined its behavioural and pharmacological bases...
- Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heartT Nishikimi
Research Institute, National Cardiovascular Center, Suita, Osaka 565, Japan
Am J Physiol Heart Circ Physiol 279:H3031-9. 2000....
- Sex differences in prenatally programmed anxiety behaviour in rats: differential corticotropin-releasing hormone receptor mRNA expression in the amygdaloid complexPaula J Brunton
Laboratory of Neuroendocrinology, Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
Stress 14:634-43. 2011..In conclusion, sex differences in anxiety-type behaviour in PNS rats may be explained by differential mRNA expression for CRH-R1 (pro-anxiogenic) and CRH-R2 (pro-anxiolytic) in the amygdaloid complex...
- Activation of CRHR2 exerts an inhibitory effect on the expression of collapsin response mediator protein 3 in hippocampal neuronsYanming Chen
Department of Physiology and The Key Laboratory of Molecular Neurobiology of Ministry of Education, Second Military Medical University, Shanghai 200433, PR China
Neuropeptides 46:93-8. 2012..In the present study, we determined the effects of CRHR1 and CRHR2 on CRMP3 expression in cultured hippocampal neurons...
- CRH-R1 and CRH-R2 differentially modulate dendritic outgrowth of hippocampal neuronsHui Sheng
Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People s Republic of China
Endocrine 41:458-64. 2012..These effects can be reversed by the CRH-R2 antagonist astressin 2B. Our results suggest that CRH-R1 and CRH-R2 differentially modulate the dendritic growth of hippocampal neurons in culture...
- Quantitative trait locus for body weight identified on rat chromosome 4 in inbred alcohol-preferring and -nonpreferring rats: potential implications for neuropeptide Y and corticotrophin releasing hormone 2John Paul Spence
Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, IN 46202, USA
Alcohol 47:63-7. 2013..Both Npy and Crfr2 have been previously identified as candidate genes of interest underlying the chromosome 4 QTL for alcohol consumption in iP and iNP rats...
- Hypothalamic expression of urocortin 3 and the type 2 corticotropin-releasing factor receptor is regulated according to feeding state in lean but not obese Zucker ratsAnne Marie Poulin
Faculte de Medecine, Département Psychiatrie et Neurosciences, Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Québec QC G1V 4G5, Canada
Neuropharmacology 63:147-53. 2012..This article is part of a Special Issue entitled 'Central Control of Food Intake'...
- Intravenous injection of urocortin 1 induces a CRF2 mediated increase in circulating ghrelin and glucose levels through distinct mechanisms in ratsLixin Wang
CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at University of California Los Angeles, Los Angeles, CA 90073, USA
Peptides 39:164-70. 2013....
- Peripheral and central administration of exogenous urocortin 1 disrupts the fasted motility pattern of the small intestine in rats via the corticotrophin releasing factor receptor 2 and a cholinergic mechanismYan Yin
Department of Gastroenterology, The Second Affiliated Hospital of Xi an Jiaotong University, Xi an, China
J Gastroenterol Hepatol 23:e79-87. 2008..The present study aimed to determine the effects of urocortin 1 on small intestinal motility in rats and the CRF receptor subtypes and autonomic pathways mediating the effects...
- Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kappaB activationMan Huang
Department of Pharmacology and Experimental Therapeutics Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
J Mol Endocrinol 42:397-405. 2009..The precise role of cardiac Ucn in vivo remains to be elucidated...
- Novel action of pituitary urocortin 2 in the regulation of expression and secretion of gonadotropinsTakahiro Nemoto
Department of Physiology, Nippon Medical School, Tokyo, Japan
J Endocrinol 201:105-14. 2009..These findings suggest that pituitary Ucn 2 is involved in the regulatory mechanism of the expression and secretion of gonadotropins through its tonic and inhibitory action on gonadotrophs in a paracrine manner...
- Corticotropin-releasing hormone receptor subtypes in the rat anterior pituitary after two types of restraint stressVera Klenerova
Laboratory of Biochemical Neuropharmacology, Institute of Medical Biochemistry, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
Ann N Y Acad Sci 1148:415-20. 2008..Our data demonstrated that these stressors did not change CRH-R2alpha mRNA, unlike the very significant response of CRH-R1 to IMO...
- Social defeat stress activates medial amygdala cells that express type 2 corticotropin-releasing factor receptor mRNAE M Fekete
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Neuroscience 162:5-13. 2009..The results indicate CRF(2) receptor-positive neurons in the posterior medial amygdala are involved in the neural response to social defeat...
- Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brainT W Lovenberg
Department of Molecular Biology, Neurocrine Biosciences Inc, San Diego, CA 92121
Proc Natl Acad Sci U S A 92:836-40. 1995..clone that encodes a second member of the corticotropin-releasing factor (CRF) receptor family, designated as the CRF2 receptor. The cDNA was identified using oligonucleotides of degenerate sequence in a PCR paradigm...
- Corticotropin-releasing factor in the dorsal raphe nucleus increases medial prefrontal cortical serotonin via type 2 receptors and median raphe nucleus activityGina L Forster
Division of Basic Biomedical Sciences and Neuroscience Group, Sanford School of Medicine, University of South Dakota, 414 E Clark Street, Vermillion, SD 57069, USA
Eur J Neurosci 28:299-310. 2008..This response was blocked by CRF receptor type 2 antagonism in the dorsal raphe. Overall, these results highlight complex CRF modulation of medial prefrontal cortex serotonergic activity at the level of the raphe nuclei...
- Restraint stress increases serotonin release in the central nucleus of the amygdala via activation of corticotropin-releasing factor receptorsBing Mo
Biology Department and Neuroscience Group, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069, USA
Brain Res Bull 76:493-8. 2008..Furthermore, the results imply that corticotropin-releasing factor mediated serotonergic activity in central nucleus of the amygdala may be an important component of a stress response...
- Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain-related synaptic facilitation and behaviorYu Fu
Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
J Neurosci 28:3861-76. 2008..site of extrahypothalamic expression of corticotropin-releasing factor (CRF) and its G-protein-coupled CRF1 and CRF2 receptors is the amygdala, a key player in emotions and affective disorders...
- Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbensJodi L Lukkes
Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069 2390, USA
Eur J Pharmacol 578:185-93. 2008..These results suggest that the opposing effects of dorsal raphé CRF on 5-HT release in the nucleus accumbens are dependent on differential activation of CRF(1) and CRF(2) receptors in the dorsal raphé nucleus...
- Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2X Guan
Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
Neuroscience 161:665-70. 2009..Our data suggest that short-term cocaine withdrawal treatment may cause synaptic plasticity in hippocampus partially via changing the activity of CRF(2) in the hippocampus...
- Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic-pituitary-adrenal axis and induces anxiety-like behavior in adult male rat offspringJ M Fan
Division of Neurobiology and Physiology, College of Life Sciences, School of Medicine, Zhejiang University, Hangzhou, China
Neuroscience 159:1363-73. 2009..factor receptor type 1 (CRHR1) expression but decreased corticotropin-releasing factor receptor type 2 (CRHR2) in the paraventricular nucleus of the hypothalamus (PVN), enhanced CRHR1 mRNA and CRHR2 mRNA expression in the ..
- Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathwayJin Tao
Department of Neurobiology, Laboratory of Aging and Nervous Diseases, Medical College of Soochow University, Suzhou, PR China
Cell Signal 21:1436-43. 2009..In summary, activation of CRFR2 inhibits P-currents in Purkinje neurons via G(o)alpha-dependent PLC/PKCepsilon pathway, which might contribute to its physiological functions in the cerebellum...
- Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptorAndreas Stengel
Center for Neurovisceral Sciences and Women s Health CURE, Building 115, Room 117, Veterans Administration Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
Endocrinology 150:4911-9. 2009..Activation of nesfatin-1 neurons by cholecystokinin at sites regulating food intake may suggest a role in gut peptide satiation effect...
- Local secretion of urocortin 1 promotes microvascular permeability during lipopolysaccharide-induced inflammationElizabeth L Cureton
Department of Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Endocrinology 150:5428-37. 2009..Ucn1's effect on L(p) is partially mediated by the CRH-R(2) receptor and acts independently of the c-JUN N-terminal kinase signal transduction pathway...
- Excitatory responses of cardiovascular activities to urocortin3 administration into the PVN of the ratXia Li
Department of Neurology, Huashan Hospital Affiliated to Fudan University, Shanghai, PR China
Auton Neurosci 154:108-11. 2010Urocortin3 (Ucn3) is an endogenous ligand for corticotropin-releasing factor receptor subtype 2 (CRF2R)...
- The serotonergic projection from the median raphe nucleus to the ventral hippocampus is involved in the retrieval of fear memory through the corticotropin-releasing factor type 2 receptorYu Ohmura
Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Neuropsychopharmacology 35:1271-8. 2010..These results indicated that endogenous CRF and/or related ligands that were released in the MRN could activate the CRF(2) receptor and stimulate serotonin release in the ventral hippocampus, thereby inducing fear memory retrieval...
- Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: differential effects of acute psychological and physical stressorsDervla O'Malley
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
Peptides 31:662-70. 2010..This study demonstrates that acute stressors alter colonic CRF receptor expression in a manner that is determined by the underlying stress sensitivity of the subject...
- CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axisEmily G Lowery
Department of Psychology, University of North Carolina, Chapel Hill, NC, USA
Neuropsychopharmacology 35:1241-52. 2010..Furthermore, normal HPA axis signaling is not necessary to achieve binge-like drinking behavior...
- The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activityKatharina Schulz
Leibniz Institut fur Molekulare Pharmakologie, Robert Rossle Strasse 10, 13125 Berlin, Germany
J Biol Chem 285:32878-87. 2010..In the case of the corticotropin-releasing factor receptor subtypes, the use of conventional and pseudo signal peptides have an unexpected influence on signal transduction...
- Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2α in MIN6 insulinoma cells and rodent isletsM O Huising
The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Endocrinology 152:138-50. 2011..We postulate that differential effect of GCs on the expression of CRFR1 and CRFR2α in the endocrine pancreas represent a mechanism to shift sensitivity from CRFR1 to CRFR2 ligands...
- Topographical distribution of corticotropin-releasing factor type 2 receptor-like immunoreactivity in the rat dorsal raphe nucleus: co-localization with tryptophan hydroxylaseJ L Lukkes
Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA
Neuroscience 183:47-63. 2011....
- Corticotropin-releasing hormone receptor-1 and 2 activity produces divergent resistance against stress-induced pulmonary Streptococcus pneumoniae infectionByung Jin Kim
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, United States
J Neuroimmunol 237:57-65. 2011..CRH receptor-mediated effects on immune responses could prove valuable for novel therapeutics...
- Stimulation of neurons in rat ARC inhibits gastric acid secretion via hypothalamic CRF1/2- and NPY-Y1 receptorsJohannes J Tebbe
Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Philipps Universitat Marburg, 35033 Marburg, Germany
Am J Physiol Gastrointest Liver Physiol 285:G1075-83. 2003..Our results indicate that activation of neurons in the ARC inhibits gastric acid secretion via CRF1/2 and NPY-Y1 receptor-mediated pathways in the PVN...
- Urocortin stimulates tyrosine hydroxylase activity via the cAMP/protein kinase a pathway in rat Pheochromocytoma PC12 cellsToru Nanmoku
Department of Clinical Pathology, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
Neurosci Lett 382:124-7. 2005..In conclusion, we have demonstrated that urocortin stimulates catecholamine biosynthesis via the cAMP/protein kinase A pathway in PC12 cells, where both urocortin and its receptor, CRF-R2, are expressed...
- Regulation of corticotropin-releasing factor receptor type 2beta mRNA by mitogen-activated protein kinases in aortic smooth muscle cellsKazunori Kageyama
The Third Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
Regul Pept 126:223-31. 2005..Alternatively, anisomycin may increase CRFR2beta mRNA levels indirectly as a consequence of blocking protein synthesis...
- The type 2 corticotrophin-releasing hormone receptor mediates orexin A-induced luteinising hormone suppression in ovariectomised ratsT Iwasa
Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
J Neuroendocrinol 19:732-8. 2007..These findings suggest that CRH-R2 mediates orexin A-induced LH suppression and it is possible that CRH and UcnII in the hypothalamus are involved in this pathway...
- Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivitySam R J Hoare
Department of Pharmacology, Neurocrine Biosciences Inc, 12790 El Camino Real, San Diego, CA 92130, USA
Peptides 26:457-70. 2005The CRF2 receptor is involved in stress responses, cardiovascular function and gastric motility...
- Role of corticotropin-releasing factor receptor-2 in stress-induced suppression of pulsatile luteinizing hormone secretion in the ratXiao Feng Li
Division of Reproductive Health, Endocrinology, and Development, New Hunt s House, King s College London, London SE1 1UL, United Kingdom
Endocrinology 146:318-22. 2005....
- CRF receptor type 1 and 2 expression and anatomical distribution in the rat colonEkaterini Chatzaki
Neurocrine Biosciences Inc, San Diego, CA 92121, USA
J Neurochem 90:309-16. 2004..These results demonstrate expression of both CRF receptor types in the rat colon and support a role for their involvement in regulating peripheral effects of CRF ligands...
- Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activationGlenn R Valdez
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
Alcohol Clin Exp Res 28:865-72. 2004..characterization of these receptors, the objective of the following experiments was to characterize the role of CRF2 receptors in the interaction between alcohol and stress by examining the effects of CRF2 receptor activation in the ..
- Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleusHeidi E W Day
Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
J Comp Neurol 474:364-78. 2004..The differential distribution of distinct neurochemical phenotypes lends support to the idea of functional differentiation of the DR...
- Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressinAlexandra Wigger
Max Planck Institute of Psychiatry, Behavioural Neuroendocrinology, Munich, Germany
Neuropsychopharmacology 29:1-14. 2004....
- Corticotropin-releasing factor receptor types 1 and 2 are differentially expressed in pre- and post-synaptic elements in the post-natal developing rat cerebellumJ D Swinny
Laboratory for Cell Biology and Electron Microscopy, Department of Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
Eur J Neurosci 18:549-62. 2003..Finally, the distinct expression profiles of receptors along structural domains of Purkinje cells suggest that the role for these receptors is to modulate afferent inputs...
- Chronic cocaine administration switches corticotropin-releasing factor2 receptor-mediated depression to facilitation of glutamatergic transmission in the lateral septumJie Liu
Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555 1031, USA
J Neurosci 25:577-83. 2005..CRF-related peptides that activate two different and synaptically localized G-protein-coupled receptors, CRF1 and CRF2. These peptides and their receptors have been implicated in stress responses and stress with cocaine abuse...
- Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressorsCatherine L Rivier
The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
Endocrinology 144:2396-403. 2003..Finally, we showed that peripheral endogenous CRF restrains the ability of LPS to release cytokines...
- Corticotropin-releasing factor receptor type 2 messenger ribonucleic acid in rat pituitary: localization and regulation by immune challenge, restraint stress, and glucocorticoidsKazunori Kageyama
The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
Endocrinology 144:1524-32. 2003CRF receptor 2 (CRF R2) has been identified in the rat pituitary. However, the cell types that express the receptor remained to be determined. In the present study, we localized CRF R2 mRNA in gonadotropes of the anterior pituitary...
- Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intakeKarine Proulx
McGill University, Department of Psychiatry, Douglas Hospital Research Center, Montreal, Quebec, Canada H4H 1R3
Endocrinology 143:4683-92. 2002..We conclude that despite adult-like effects of leptin on POMC, NPY, and CRFR-2 expression in neonates, leptin does not regulate food intake during early development...
- Antalarmin blockade of corticotropin releasing hormone-induced hypertension in ratsR J Briscoe
Department of Pharmacology, University of Michigan, 48109, Ann Arbor, MI, USA
Brain Res 881:204-7. 2000..of antalarmin, a novel, small molecule CRH1 receptor antagonist, and alpha-helical CRH(9-41), a peptidic CRHR1/CRHR2 antagonist to attempt to determine the receptor mechanisms through which CRH is acting in both of these situations...
- Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2T Kishimoto
Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA
Nat Genet 24:415-9. 2000..hormone (Crh), a 41-residue polypeptide, activates two G-protein-coupled receptors, Crhr1 and Crhr2, causing (among other transductional events) phosphorylation of the transcription factor Creb...
- Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2S C Coste
Departments of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR, USA
Nat Genet 24:403-9. 2000..to stress, and the related hormone urocortin (Ucn) are coordinated by two receptors, Crhr1 (encoded by Crhr) and Crhr2. These receptors may exhibit distinct functions due to unique tissue distribution and pharmacology...
- Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortinJ Gottowik
Pharma Division, F Hoffmann La Roche Ltd, Basel, Switzerland
Neuropharmacology 36:1439-46. 1997....
- Cloning and characterization of human urocortinC J Donaldson
Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla 92037, USA
Endocrinology 137:2167-70. 1996..The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33)...
- The use of H-2 mutants as models for the study of T cell activationI F McKenzie
Immunol Rev 35:179-230. 1977
- Endogenous expression and in vitro study of CRF-related peptides and CRF receptors in the rat gastric antrumChristophe Porcher
Groupe d Etude du Stress et des Interactions Neuro Digestives GESIND, EA3744, CHRU Grenoble, BP 217, Grenoble 38043, France
Peptides 27:1464-75. 2006..CRF-like peptides, urocortin 1 (UCN 1) and UCN 2, inhibit gastric emptying and stimulate colonic motility through CRF2 and CRF1 receptors, respectively...
- Central type 2 corticotropin-releasing hormone receptor mediates hypothalamic-pituitary-adrenocortical axis activation in the ratHiroshi Maruyama
Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University, Kochi, Japan
Neuroendocrinology 86:1-16. 2007..These results indicate that there is a CRHR-2-mediated mechanism in the brain that stimulates CRH- and AVP-producing neurons in the PVN which results in the promotion of plasma ACTH secretion...
- A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent ratsCindy K Funk
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Brain Res 1155:172-8. 2007..These data demonstrate an opposing role of the CRF(2) receptor subtype within the CeA in mediating ethanol self-administration in withdrawn, dependent and nondependent rats...
- Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the ratBin Wang
Behavioral Neuroscience Branch, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 193:283-94. 2007..The effects of selective CRF antagonists have not yet been reported...
- Cocaine withdrawal enhances long-term potentiation induced by corticotropin-releasing factor at central amygdala glutamatergic synapses via CRF, NMDA receptors and PKASebastian Pollandt
University of Texas Medical Branch, Department of Pharmacology and Toxicology, Galveston, TX 77555 1031, USA
Eur J Neurosci 24:1733-43. 2006..After prolonged withdrawal, CRF-induced LTP was dependent on activation of CRF2, CaV2...
- Activation of corticotropin-releasing factor receptor-2 causes bronchorelaxation and inhibits pulmonary inflammation in miceJames D Moffatt
The Sackler Institute of Pulmonary Pharmacology, King s College London, Guy s Campus, London, UK
FASEB J 20:1877-9. 2006..Therefore, CRF(2) agonists appear to have both bronchorelaxant and anti-inflammatory activities and might represent an interesting therapeutic approach to the treatment of inflammatory lung diseases...
- The dynamic developmental localization of the full-length corticotropin-releasing factor receptor type 2 in rat cerebellumNatalia V Gounko
Department of Cell Biology, Laboratory for Electron Microscopy, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
Eur J Neurosci 23:3217-24. 2006b>Corticotropin releasing factor receptor 2 (CRF-R2) is strongly expressed in the cerebellum and plays an important role in the development of the cerebellar circuitry, particularly in the development of the dendritic trees and afferent ..
- Lack of interaction between etifoxine and CRF1 and CRF2 receptors in rodentsMarc Verleye
Biocodex, Departement de Pharmacologie, Zac de Mercières, 60200 Compiegne, France
Neurosci Res 56:53-60. 2006..Blockade of CRF1 and CRF2 receptors can underlie the anxiolytic effects of drugs...
- Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulationRory J McCrimmon
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
J Clin Invest 116:1723-30. 2006..Our data suggest that regulation of the CRR is largely determined by the interaction between CRFR2-mediated suppression and CRFR1-mediated activation in the VMH...
- Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitisJennifer LaBerge
Dept of Anatomy, University of Vermont College of Medicine, Burlington, VT 05405, USA
Am J Physiol Regul Integr Comp Physiol 291:R692-703. 2006..CRF may contribute to urinary bladder overactivity and altered sensory processing with CYP-induced cystitis...
- Modulation of Ca2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cellsKazunori Kageyama
Department of Endocrinology, Metabolism and Infectious Diseases Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
Peptides 27:1814-9. 2006..by the seven transmembrane-domain G-protein-coupled receptors, the CRF receptors type 1 (CRF1 receptor) and type 2 (CRF2 receptor)...
- Chronic disruption of body weight but not of stress peptides or receptors in rats exposed to repeated restraint stressRuth B S Harris
Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, GA 30605, USA
Horm Behav 49:615-25. 2006....
- Evidence supporting a role for corticotropin-releasing factor type 2 (CRF2) receptors in the regulation of subpopulations of serotonergic neuronsDaniel R Staub
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK
Brain Res 1070:77-89. 2006..Some of these effects may be mediated via the CRF type 2 (CRF2) receptor on serotonergic neurons in the dorsal raphe nucleus (DR)...
- Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious ratsChih Yen Chen
Division of Gastroenterology, Taipei Veterans General Hospital, Taiwan
Gastroenterology 129:8-25. 2005..Although it has been shown that des-acyl ghrelin decreases food intake and gastric emptying, no previous studies have examined the effects of des-acyl ghrelin on physiologic fed and fasted motor activity in the gastrointestinal tract...
- Differential profile of CRF receptor distribution in the rat stomach and duodenum assessed by newly developed CRF receptor antibodiesEkaterini Chatzaki
Neurocrine Biosciences Inc, San Diego, California 92121, USA
J Neurochem 88:1-11. 2004..We mapped the distribution of CRF receptor type 1 (CRF1) and 2 (CRF2) in the rat upper GI...
- Neuronal activity and CRF receptor gene transcription in the brains of rats with colitisChristophe Porcher
Groupe d Etude du Stress et des Interactions Neuro Digestives EA 3744, Hopital Albert Michallon, Centre Hospitalier Universitaire, 38043 Grenoble Cedex 09, France
Am J Physiol Gastrointest Liver Physiol 287:G803-14. 2004..No expression of CRF2 receptor transcripts was observed in the PVN, either in basal conditions or after TNBS...
- Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypesLin Lu
Institute of Mental Health, West China University of Medical Sciences, Chengdu, China Medical Center of Fudan University, Shanghai, China
J Neurochem 84:1378-86. 2003..These results suggest that the CRF receptor antagonist, particularly the CRF receptor subtype 1 antagonist, might be of some value in the treatment of cocaine addiction and cocaine-related behavioral disorders...
- Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal intervalEva M Fekete
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
Neuropsychopharmacology 32:1052-68. 2007..The results implicate the VMN and PVN of the hypothalamus as sites for Ucn 3-CRF(2) control of food intake...
- Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type IWard A Pedersen
Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
J Neurosci 22:404-12. 2002..G-protein-coupled receptors have been identified that bind CRH and/or urocortin I and II, designated CRHR1 and CRHR2, both of which are present in hippocampal regions of mammalian brain...
- Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptorK Lewis
Clayton Foundation Laboratories for Peptide Biology and Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 98:7570-5. 2001..Urocortin III is selective for type 2 CRF receptors and thus represents another potential endogenous ligand for these receptors...
- Identification and characterization of multiple corticotropin-releasing factor type 2 receptor isoforms in the rat esophagusS Vincent Wu
Center for Ulcer Research and Education, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90073, USA, and Division of Gastroenterology, Taipei Veterans General Hospital, Taiwan
Endocrinology 148:1675-87. 2007..skin squamous epithelium and striated muscle that express high levels of corticotropin-releasing factor type 2 (CRF2) receptors or their cognate ligand urocortin (Ucn) 1, 2, and 3...
- Presynaptic localization of a truncated isoform of the type 2 corticotropin releasing factor receptor in the cerebellumJ B Tian
Department of Neuroscience, The Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
Neuroscience 138:691-702. 2006....
- Amphetamine treatment increases corticotropin-releasing factor receptors in the dorsal raphe nucleusRonald B Pringle
Division of Basic Biomedical Sciences and Neuroscience Group, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA
Neurosci Res 62:62-5. 2008..No changes in CRF(1) receptor densities were observed following amphetamine treatment or during withdrawal. Selective increases in dRN CRF(2) receptors may be related to increased anxiety-like behaviors following psychostimulant use...
- Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulationHaiying Cheng
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Am J Physiol Endocrinol Metab 293:E705-12. 2007..The balance between these two opposing CRFRs in this key glucose-sensing region may play an important role in determining the magnitude of CRRs to acute hypoglycemia...
- Opioid and Dopamine Mechanisms of Heroin RelapseGLENN VALDEZ; Fiscal Year: 2006....
- NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONSCatherine Rivier; Fiscal Year: 2004..Collectively, these results will provide novel and comprehensive information regarding the neurocircuitries through which NO or CO modulate the response of the rat HPA to a neurogenic stress. ..
- Role of AMPK in hypoglycemia-sensing in the ventromedial hypothalamusRORY MCCRIMMON; Fiscal Year: 2008..Finally, the proposal aims to obtain data that will support the hypothesis that recurrent hypoglycemia induces mitochondrial biogenesis in the VMH, an effect that may be mediated by AMPK. ..
- A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASECatherine Rivier; Fiscal Year: 2008..Collectively, these studies will advance our understanding of the effects of alcohol on male reproductive functions and the mechanisms that mediate them. ..