Genomes and Genes
Gene Symbol: Crhr1
Description: corticotropin releasing hormone receptor 1
Alias: CRFR1, CRH-R 1, corticotropin-releasing factor receptor 1, CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRH-R-1, CRH-R1, corticotrophin releasing hormone receptor 1, corticotropin releasing hormone 1
Publications112 found, 100 shown here
- Urocortin promotes the development of vasculitis in a rat model of thromboangiitis obliterans via corticotrophin-releasing factor type 1 receptorsYouhua Xu
Department of Pharmacology, Nanjing Medical University, Nanjing, China
Br J Pharmacol 157:1368-79. 2009..Urocortin is a locally expressed pro-inflammatory peptide. Here we have examined the effects of urocortin on sodium laurate-induced peripheral arterial vasculitis in rats, modelling the mechanisms of thromboangiitis obliterans (TAO)...
- Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawalJavier Navarro-Zaragoza
Department of Pharmacology, University School of Medicine, University of Murcia, Murcia, Spain
Mol Pharmacol 77:864-73. 2010..However, CRF1R activation may not contribute to the functional interaction between NA and CRF systems in mediating morphine withdrawal-activation of brain stress neurocircuitry...
- Regulation of corticotropin-releasing factor (CRF) type-1 receptor gene expression by CRF in the hypothalamusShun ichiro Konishi
Department of Bioregulation, Institute of Gerontology, Nippon Medical School, Kawasaki 211 8533, Japan
Endocr J 50:21-36. 2003..These results demonstrate that CRF directly affects hypothalamic neurons to increase CRFR-1 mRNA expression, providing evidence of a direct role for CRF in the regulation of CRFR-1 expression of hypothalamic neurons...
- Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 in human embryonic kidney 293 cellsDoreen Wietfeld
Institute of Molecular Pharmacology, Robert Rossle Strasse 10, Berlin 13125, Germany
J Biol Chem 279:38386-94. 2004..Corresponding to a high and low affinity ligand binding site, sauvagine and other peptidic CRFR1 ligands evoked high and low potency responses of G protein activation, differing by 64-fold in their EC(50) values ..
- G protein-coupled receptor kinase 2 involvement in desensitization of corticotropin-releasing factor (CRF) receptor type 1 by CRF in murine corticotrophsKazunori Kageyama
Department of Endocrinology, Metabolism, and Infectious Diseases, Hirosaki University School of Medicine, Hirosaki, Aomori 036 8562, Japan
Endocrinology 147:441-50. 2006Hypothalamic CRF stimulates synthesis and secretion of ACTH via CRF receptor type 1 (CRFR1) in the anterior pituitary gland. After agonist-activated stimulation of receptor signaling, CRFR1 is down-regulated and desensitized...
- Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in ratsMuriel Larauche
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
Am J Physiol Gastrointest Liver Physiol 294:G1033-40. 2008..These data support a major role for CRF(1) in both the development and maintenance of visceral hyperalgesia induced by repeated stress and indicate a possible role of peripheral CRF receptors in such mechanisms...
- Involvement of microglial cells in infrasonic noise-induced stress via upregulated expression of corticotrophin releasing hormone type 1 receptorF Du
Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, PR China
Neuroscience 167:909-19. 2010..These findings suggest that in addition to the PVN neurons, microglial cells are the effector cells for infrasound as well, and involve in the infrasound-induced stress through upregulated expression of CRH-R1...
- Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-AmericansJ Licinio
Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
Mol Psychiatry 9:1075-82. 2004..CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety...
- The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiologyEdward W Hillhouse
The Leeds Institute of Genetics, Health and Therapeutics, The University of Leeds, Leeds LS2 9NL, UK
Endocr Rev 27:260-86. 2006..The type of activating agonist, receptor, and target cell appears to play a major role in determining the overall signaling and biological responses in health and disease...
- Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain-related synaptic facilitation and behaviorYu Fu
Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
J Neurosci 28:3861-76. 2008A major site of extrahypothalamic expression of corticotropin-releasing factor (CRF) and its G-protein-coupled CRF1 and CRF2 receptors is the amygdala, a key player in emotions and affective disorders...
- Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathwaysMuriel Larauche
CURE Digestive Diseases Research Center, Diseases Research Center, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 297:G215-27. 2009..Stresslike colonic alterations induced by ip cortagine in rats and mice through restricted activation of peripheral CRF(1) receptors support a role for peripheral CRF(1) signaling as the local arm of the colonic response to stress...
- CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axisEmily G Lowery
Department of Psychology, University of North Carolina, Chapel Hill, NC, USA
Neuropsychopharmacology 35:1241-52. 2010..Furthermore, normal HPA axis signaling is not necessary to achieve binge-like drinking behavior...
- Pain-related anxiety-like behavior requires CRF1 receptors in the amygdalaGuangchen Ji
Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
Mol Pain 3:13. 2007Corticotropin-releasing factor receptor CRF1 has been implicated in the neurobiological mechanisms of anxiety and depression. The amygdala plays an important role in affective states and disorders such as anxiety and depression...
- Alterations in hypothalamic-pituitary-adrenal axis activity and in levels of proopiomelanocortin and corticotropin-releasing hormone-receptor 1 mRNAs in the pituitary and hypothalamus of the rat during chronic 'binge' cocaine and withdrawalYan Zhou
Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Brain Res 964:187-99. 2003....
- Corticotropin-releasing factor receptor types 1 and 2 are differentially expressed in pre- and post-synaptic elements in the post-natal developing rat cerebellumJ D Swinny
Laboratory for Cell Biology and Electron Microscopy, Department of Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
Eur J Neurosci 18:549-62. 2003..Finally, the distinct expression profiles of receptors along structural domains of Purkinje cells suggest that the role for these receptors is to modulate afferent inputs...
- Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptorsMatthew J Mahon
Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Wellman 501, Boston, MA 02114 2696, USA
FEBS Lett 579:803-7. 2005..Fluphenazine, a calmodulin antagonist, enhances PTH-mediated accumulation of total inositol phosphates, suggesting that calmodulin regulates signaling via phospholipase C...
- Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptorKristina A Fenoglio
Department of Anatomy Neurobiology, Med Sci I, ZOT 4475, University of California, Irvine, California 92697 4475, USA
Endocrinology 146:4090-6. 2005..Transient, partial selective blockade of CRF1 in nonhandled rats improved memory functions on both the Morris watermaze and object recognition tests to levels ..
- Augmented cocaine seeking in response to stress or CRF delivered into the ventral tegmental area following long-access self-administration is mediated by CRF receptor type 1 but not CRF receptor type 2Jordan M Blacktop
Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin 53201, USA
J Neurosci 31:11396-403. 2011..These findings reveal that excessive cocaine use increases susceptibility to stressor-induced relapse in part by augmenting CRF-R1-dependent regulation of addiction-related neurocircuitry in the VTA...
- Anxiogenic effects of CGRP within the BNST may be mediated by CRF acting at BNST CRFR1 receptorsK S Sink
Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Center, Emory University, Atlanta, GA 30329, USA
Behav Brain Res 243:286-93. 2013..With this in mind, the present set of experiments was designed to examine the role of CRFR1 signaling in the anxiogenic effects of CGRP within the BNST and to determine whether CRF from BNST neurons ..
- Gestational hypoxia induces sex-differential methylation of Crhr1 linked to anxiety-like behaviorXi Wang
Division of Neurobiology and Physiology, Department of Basic Medical Sciences, School of Medicine, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China
Mol Neurobiol 48:544-55. 2013..behavior in male P90 offspring and activation of corticotropin-releasing hormone (CRH) and CRH type-1 receptor (CRHR1) mRNA in the hypothalamic paraventricular nucleus (PVN) and in male E19 hypothalamus...
- The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in ratsMulugeta Million
CURE Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America Oppenheimer Family Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America
PLoS ONE 8:e73749. 2013b>Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases...
- CRHR1 links peripuberty stress with deficits in social and stress-coping behaviorsVandana Veenit
Laboratory of Behavioral Genetics, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
J Psychiatr Res 53:1-7. 2014..The corticotropin releasing hormone (CRH) and the CRH receptor 1 (CRHR1) have been implicated in the link between early life adversity and adult anxiety and depression, with rodent ..
- Expression of urocortin and its receptors in the rat epididymisAdriana De Luca
Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via Veterinaria 1, I 80137 Naples, Italy Electronic address
Reprod Biol 14:140-7. 2014..actions of CRH family peptides are mediated by two types of G-protein-coupled receptors, CRH type 1 receptor (CRHR1) and CRH type 2 receptor (CRHR2)...
- Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndromeMaria M Buckley
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland Department of Physiology, University College Cork, Cork, Ireland
J Physiol 592:5235-50. 2014..5 mg kg(-1) i.p) with or without the CRFR1 antagonist antalarmin (10 mg kg(-1) i.p)...
- Prenatal stress, anxiety and depression: a mechanism involving CRH peptide familyJun Ming Fan
Division of Neurobiology and Physiology, Department of Basic Medical Sciences, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China
Neuro Endocrinol Lett 35:429-39. 2014..We present evidence demonstrating prenatal hypoxia exposure induced anxiety-like behavior in adult male rat offspring and CRHR1 in PVN of the hypothalamus is involved.
- Impaired miR449a-induced downregulation of Crhr1 expression in low-birth-weight ratsTakahiro Nemoto
Department of PhysiologyNippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
J Endocrinol 224:195-203. 2015..NBW) offspring and impaired downregulation of corticotropin-releasing factor receptor type 1 (CRF-R1, Crhr1) in the anterior pituitary in restraint...
- Lifelong disturbance of serotonin transporter functioning results in fear learning deficits: Reversal by blockade of CRF1 receptorsElisabeth Y Bijlsma
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Brain Center Rudolf Magnus, Utrecht University, The Netherlands Electronic address
Eur Neuropsychopharmacol 25:1733-43. 2015..the known interactions between serotonin and corticotropin-releasing factor (CRF), we studied the effect of the CRFR1 antagonist CP154,526 on behavioral changes observed and determined CRF1 receptor levels in SERT(-/-) rats...
- Noise Stress-Induced Changes in mRNA Levels of Corticotropin-Releasing Hormone Family Molecules and Glucocorticoid Receptors in the Rat BrainE Eraslan
Department of Physiology, Faculty of Veterinary Medicine, Istanbul University, Istanbul, Turkey
Folia Biol (Praha) 61:66-73. 2015....
- Corticotropin-releasing factor as well as opioid and dopamine are involved in tail-pinch-induced food intake of ratsS Samarghandian
Department of Physiology, Nippon Medical School, 1 1 5 Sendagi Bunkyo ku, Tokyo 113 8602, Japan
Neuroscience 116:519-24. 2003..The results also suggest that brain CRF has dual effects on food intake, hyperphagia and anorexia, in a stress-dependent manner...
- Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressorsCatherine L Rivier
The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
Endocrinology 144:2396-403. 2003..Finally, we showed that peripheral endogenous CRF restrains the ability of LPS to release cytokines...
- Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stressMarianne B Muller
Max Planck Institute of Psychiatry, Kraepelinstr 2 10, Munich 80804, Germany
Nat Neurosci 6:1100-7. 2003..To differentiate the CNS pathways involving CRH and CRH receptor 1 (Crhr1) that modulate behavior from those that regulate neuroendocrine function, we generated a conditional knockout ..
- CRF receptor type 1 and 2 expression and anatomical distribution in the rat colonEkaterini Chatzaki
Neurocrine Biosciences Inc, San Diego, CA 92121, USA
J Neurochem 90:309-16. 2004..These results demonstrate expression of both CRF receptor types in the rat colon and support a role for their involvement in regulating peripheral effects of CRF ligands...
- The signal peptide of the rat corticotropin-releasing factor receptor 1 promotes receptor expression but is not essential for establishing a functional receptorMartina Alken
Forschungsinstitut für Molekulare Pharmakologie FMP, Robert Rossle Str 10, 13125 Berlin, Germany
Biochem J 390:455-64. 2005..Thus the signal peptide of the CRF-R1 promotes an early step of receptor biogenesis, such as targeting of the nascent chain to the ER membrane and/or the gating of the protein-conducting translocon of the ER membrane...
- Differential role of corticotrophin-releasing factor receptor types 1 and 2 in stress-induced suppression of pulsatile luteinising hormone secretion in the female ratX F Li
Division of Reproductive Health, Endocrinology and Development, King s College London, Guy s Campus, London, UK
J Neuroendocrinol 18:602-10. 2006..These results suggest that hypoglycaemia and LPS stress-induced LH suppression involves activation of CRF(2) while restraint stress-induced inhibition of LH pulses involves both CRF(1) and CRF(2)...
- Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulationHaiying Cheng
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Am J Physiol Endocrinol Metab 293:E705-12. 2007..The VMH expresses both subtypes of CRF receptors, CRFR1 and CRFR2...
- Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbensJodi L Lukkes
Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069 2390, USA
Eur J Pharmacol 578:185-93. 2008..These results suggest that the opposing effects of dorsal raphé CRF on 5-HT release in the nucleus accumbens are dependent on differential activation of CRF(1) and CRF(2) receptors in the dorsal raphé nucleus...
- Corticotropin-releasing hormone (CRH) depresses n-methyl-D-aspartate receptor-mediated current in cultured rat hippocampal neurons via CRH receptor type 1Hui Sheng
Department of Physiology, Ministry of Education, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
Endocrinology 149:1389-98. 2008..This effect was reversed by the CRH receptor type 1 (CRHR1) antagonist antalarmin but not by the CRHR2 antagonist astressin-2B, suggesting that CRHR1 mediated the inhibitory ..
- Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPDWoo J Kim
Department of Internal Medicine, College of Medicine, Kangwon National University, Chuncheon, Korea
Respirology 14:260-3. 2009..An association between sequence variants in the corticotrophin-releasing hormone receptor 1 (CRHR1) gene and improved lung function in asthmatics treated with inhaled corticosteroids was reported recently...
- Neonatal maternal separation elevates thalamic corticotrophin releasing factor type 1 receptor expression response to colonic distension in ratYung Wui Tjong
School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, China
Neuro Endocrinol Lett 31:215-20. 2010..The aim of our study is to examine the effect of neonatal maternal separation (NMS), an early life stress model, on the brain CRF expression following visceral pain induced by colorectal distension (CRD) stimuli in male rats...
- Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disordersJavier A Bravo
Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
Int J Neuropsychopharmacol 14:666-83. 2011..Corticotrophin-releasing factor (CRF) is the primary peptide regulating this axis, acting through two receptors: CRF1 and CRF2. The central CRF system is also a key regulator in the stress response...
- Peripheral corticotropin-releasing factor (CRF) induces stimulation of gastric contractions in freely moving conscious rats: role of CRF receptor types 1 and 2T Nozu
Department of Regional Medicine and Education, Asahikawa Medical University, Asahikawa, Japan
Neurogastroenterol Motil 25:190-7. 2013..CRF injected peripherally inhibits gastric emptying, but its effect on gastric contractions has not been clarified in freely moving conscious rats...
- Water-avoidance stress enhances gastric contractions in freely moving conscious rats: role of peripheral CRF receptorsTsukasa Nozu
Department of Regional Medicine and Education, Asahikawa Medical University, Midorigaoka Higashi 2 1 1 1, Asahikawa, 078 8510, Japan
J Gastroenterol 49:799-805. 2014..involved in the regulation of gastric motility, and enhances gastric contractions through CRF receptor type 1 (CRF1) and delays gastric emptying (GE) through CRF receptor type 2 (CRF2)...
- Individual differences in the immobility behavior in juvenile and adult rats are associated with monoaminergic neurotransmission and with the expression of corticotropin-releasing factor receptor 1 in the nucleus accumbensAndrey Sequeira-Cordero
Instituto de Investigaciones en Salud, Universidad de Costa Rica, 11501 2060 San Pedro, San Jose, Costa Rica
Behav Brain Res 252:77-87. 2013..Moreover, the expression of accumbal corticotrophin-releasing factor receptor 1 (CRFR1) was significantly different in animals with low and high immobility at both ages, with animals less immobile ..
- Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in ratsAmi Cohen
The Scripps Research Institute, La Jolla, CA, USA
Addict Biol 20:56-68. 2015..Here, we tested the hypothesis that the activation of corticotropin-releasing factor-1 (CRF1 ) receptors and emergence of the affective and motivational effects of nicotine abstinence only occur in rats with ..
- Predator odor stress alters corticotropin-releasing factor-1 receptor (CRF1R)-dependent behaviors in ratsEmily A Roltsch
Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA, USA Electronic address
Neuropharmacology 79:83-9. 2014..These results suggest that post-stress alcohol drinking may be driven by a high-nociception high-arousal state, and that brain CRF1R signaling mediates these stress effects. ..
- Histone modifications of the Crhr1 gene in a rat model of depression following chronic stressQirong Wan
Department of Psychiatry, Renmin Hospital, Wuhan University, Jiefang Road 238, Wuhan 430060, PR China
Behav Brain Res 271:1-6. 2014..of the corticotrophin-releasing hormone (CRH) and its main receptor, corticotrophin-releasing hormone receptor 1 (CRHR1). However, the precise molecular mechanisms underlying depression remain poorly understood...
- Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) ratsAndrea Cippitelli
Pharmacology Unit, School of Pharmacy, University of Camerino, Building of Experimental Medicine, Via Madonna delle Carceri, Camerino, MC, 62032, Italy
Psychopharmacology (Berl) 232:1083-93. 2015..In these animals, two single-nucleotide polymorphisms in position -1,836 and -2,097 from the first start codon of the CRF1-R transcript have been found.
- Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivoSimeon J Ramsey
Discovery Biology, Pfizer, Kent, UK
Br J Pharmacol 164:992-1007. 2011....
- Prevention of social stress-escalated cocaine self-administration by CRF-R1 antagonist in the rat VTAChristopher O Boyson
Department of Psychology, Tufts University, Medford, MA, USA
Psychopharmacology (Berl) 218:257-69. 2011..Stressful encounters can lead to activation of dopamine neurons in the ventral tegmental area (VTA), which are modulated by corticotropin releasing factor (CRF) neurons...
- Effects of acute stress on acquisition of nicotine conditioned place preference in adolescent rats: a role for corticotropin-releasing factor 1 receptorsJennifer Brielmaier
Department of Psychology, George Mason University, Fairfax, VA 22030, USA
Psychopharmacology (Berl) 219:73-82. 2012..Corticotropin-releasing factor type 1 receptors (CRF-R1) mediate physiological and behavioral stress responses. They may also mediate stress-induced potentiation of activity in multiple neural substrates implicated in nicotine reward...
- R278995/CRA0450, a corticotropin-releasing factor (CRF(1)) receptor antagonist modulates REM sleep measures in rats: Implication for therapeutic indicationAbdallah Ahnaou
Janssen Research and Development, Dept of Neurosciences, Johnson and Johnson Pharmaceutical Companies, Turnhoutseweg 30, B 2340 Beerse, Belgium
Eur J Pharmacol 680:63-8. 2012..The characteristic changes found in the sleep EEG model further support the hypothesis that R278995/CRA0450 could exert a non-sedative, antidepressant-like action...
- A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesisErin N McDowell
Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, Delaware, United States of America
PLoS ONE 7:e47359. 2012..Fetal mouse testis interstitial expression of a subset of these genes with unknown expression (Crhr1, Gramd1b, Itih5, Vgll3, and Vsnl1) was verified by whole-mount in situ hybridization...
- Upregulation of PVN CRHR1 by gestational intermittent hypoxia selectively triggers a male-specific anxiogenic effect in rat offspringJun Ming Fan
Division of Neurobiology and Physiology, Department of Basic Medical Sciences, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310027, China
Horm Behav 63:25-31. 2013..showed that the anxiogenic effect was correlated with upregulation of corticotropin-releasing hormone receptor 1 (CRHR1) in the hypothalamic paraventricular nuclei (PVN) by GIH, and was selective to male offspring...
- Non-pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responsesGuangchen Ji
Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1069, USA
Mol Pain 9:2. 2013..Our previous studies showed that endogenous activation of CRF1 receptors in an arthritis pain model contributes to amygdala hyperactivity and pain-related behaviors...
- The use of H-2 mutants as models for the study of T cell activationI F McKenzie
Immunol Rev 35:179-230. 1977
- Cloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptorM H Perrin
Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, CA 92037
Endocrinology 133:3058-61. 1993..The receptor transduces a CRF stimulated accumulation of intracellular cAMP which is inhibited by the CRF antagonist, alpha helCRF(9-41). These results suggest that the brain expresses a CRF receptor similar to that in the pituitary...
- The genomic structure of the rat corticotropin releasing factor receptor. A member of the class II G protein-coupled receptorsC H Tsai-Morris
Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
J Biol Chem 271:14519-25. 1996....
- Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behaviorS C Heinrichs
Neurocrine Biosciences, Inc, San Diego, CA 92121, USA
Regul Pept 71:15-21. 1997..differential localization in brain of three binding sites for corticotropin-releasing factor (CRF)-like peptides (CRF1 and CRF2 receptors as well as CRF-binding protein) suggest the existence of functionally distinct neurobiological ..
- Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortinJ Gottowik
Pharma Division, F Hoffmann La Roche Ltd, Basel, Switzerland
Neuropharmacology 36:1439-46. 1997..3H]-rat urocortin to homogenates of rat cerebellum and homogenates of cells stably transfected with the human CRF1, rat CRF2alpha and rat CRF2beta receptors was examined...
- Antalarmin blockade of corticotropin releasing hormone-induced hypertension in ratsR J Briscoe
Department of Pharmacology, University of Michigan, 48109, Ann Arbor, MI, USA
Brain Res 881:204-7. 2000..of antalarmin, a novel, small molecule CRH1 receptor antagonist, and alpha-helical CRH(9-41), a peptidic CRHR1/CRHR2 antagonist to attempt to determine the receptor mechanisms through which CRH is acting in both of these ..
- Functional and protein chemical characterization of the N-terminal domain of the rat corticotropin-releasing factor receptor 1B A Hofmann
Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, D 37073 Gottingen, Germany
Protein Sci 10:2050-62. 2001..Of all putative N-glycosylation sites in positions 32, 38, 45, 78, 90, and 98, all Asn residues except for Asn(32) were glycosylated to a significant extent. No O-glycosylation was observed...
- Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptorsInge Sillaber
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Science 296:931-3. 2002..Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism...
- Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemiaDaniel E Flanagan
Section of Endocrinology, Yale University School of Medicine, New Haven, CT 06520, USA
Diabetes 52:605-13. 2003..004). The addition of a CRH receptor 1 (CRHr1) antagonist to the antecedent CRH reversed the subsequent suppression of epinephrine...
- Corticotropin-releasing factor receptor type 1 is involved in the stress-induced exacerbation of chronic contact dermatitis in ratsKatsumi Kaneko
Department of Physiology, Nippon Medical School, Bunkyo ku, Tokyo, Japan
Exp Dermatol 12:47-52. 2003..a 1-h period of electric foot-shock following intraperitoneal administration of CRA1000, a selective CRFR type 1 (CRFR1) antagonist, or vehicle everyday for 9 days...
- Stimulation of neurons in rat ARC inhibits gastric acid secretion via hypothalamic CRF1/2- and NPY-Y1 receptorsJohannes J Tebbe
Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Philipps Universitat Marburg, 35033 Marburg, Germany
Am J Physiol Gastrointest Liver Physiol 285:G1075-83. 2003..study, we performed consecutive bilateral microinjections of antagonists to NPY receptor subtypes Y1 and Y2 and to CRF1/2 receptors in the PVN and of the excitatory amino acid kainate in the ARC to assess the role of NPY- and CRF-..
- Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressinAlexandra Wigger
Max Planck Institute of Psychiatry, Behavioural Neuroendocrinology, Munich, Germany
Neuropsychopharmacology 29:1-14. 2004....
- Anorectic actions of prolactin-releasing peptide are mediated by corticotropin-releasing hormone receptorsCatherine B Lawrence
School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
Am J Physiol Regul Integr Comp Physiol 286:R101-7. 2004..These results show that the anorectic actions of PrRP are mediated by central CRH receptors but not by melanocortin receptors-3/4 and that PrRP can modify Vo2...
- The effect of chronic CRF1 receptor blockade on the central CCK systems of Fawn-Hooded ratsDaniel J Lodge
Department of Pharmacology, Monash University, Box 13E, Clayton, Victoria 3800, Australia
Regul Pept 116:27-33. 2003..Therefore, these data provide clear evidence of the ability of chronic CRF(1) receptor blockade to significantly influence the central CCK systems of the rat...
- Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK CaucasiansB G Challis
University Departments of Medicine and Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
Int J Obes Relat Metab Disord 28:442-6. 2004..To investigate whether genetic variation at the loci encoding the corticotropin-releasing factor receptors-1 and -2 (CRF-R1 and CRF-R2) contributes to human obesity...
- Regulation of pituitary corticotropin releasing factor type-1 receptor mRNA binding proteins by modulation of the hypothalamic-pituitary-adrenal axisZ Wu
Center for the Study of Sex Differences, Georgetown University, Washington, DC 20057, USA
J Neuroendocrinol 16:214-20. 2004..The data suggest that CRF-R1 translation is regulated by modulation of the HPA axis through pituitary cytosolic proteins binding to the CRF-R1 5'LS...
- Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleusHeidi E W Day
Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
J Comp Neurol 474:364-78. 2004..The differential distribution of distinct neurochemical phenotypes lends support to the idea of functional differentiation of the DR...
- CRH receptor type 1 mediates continual hypoxia-induced changes of immunoreactive prolactin and prolactin mRNA expression in rat pituitaryJian Fen Xu
Division of Neurobiology and Physiology, College of Life Sciences, Zhejiang University, Yuquan Campus, Hangzhou 310027, PR China
Horm Behav 49:181-9. 2006..This study also investigates the involvement of the corticotropin-releasing hormone receptor 1 (CRH R1) in the hypoxia-induced PRL response. Hypoxia was induced by exposing the rats to high altitudes of 2 km (16...
- Corticotropin-releasing factor receptor subtype 1 and somatostatin modulating hypoxia-caused downregulated mRNA of pituitary growth hormone and upregulated mRNA of hepatic insulin-like growth factor-I of ratsXue Qun Chen
Division of Neurobiology and Physiology, College of Life Sciences, Zhejiang University Yuquan Campus, Hangzhou 310027, China
Mol Cell Endocrinol 242:50-8. 2005..mRNA and its protein in rats, and the potential involvement of corticotropin-releasing factor receptor subtype 1 (CRFR1) and SS in mediating the effects of continual hypoxia. Continual or intermittent hypoxia of 5 km (10...
- Differential regulation of corticotropin-releasing factor receptor type 1 (CRF1 receptor) mRNA via protein kinase A and mitogen-activated protein kinase pathways in rat anterior pituitary cellsTakako Moriyama
The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Aomori 036 8562, Japan
Mol Cell Endocrinol 243:74-9. 2005..These results suggested that in the rat AP, down-regulation of CRF(1) receptor mRNA levels is caused by mRNA degradation via PKA, but not by the MAP kinase pathway...
- Photoaffinity cross-linking of the corticotropin-releasing factor receptor type 1 with photoreactive urocortin analoguesOliver Kraetke
Department of Peptide Chemistry, Institute of Molecular Pharmacology FMP, 13125 Berlin, Germany
Biochemistry 44:15569-77. 2005....
- Endogenous expression and in vitro study of CRF-related peptides and CRF receptors in the rat gastric antrumChristophe Porcher
Groupe d Etude du Stress et des Interactions Neuro Digestives GESIND, EA3744, CHRU Grenoble, BP 217, Grenoble 38043, France
Peptides 27:1464-75. 2006..peptides, urocortin 1 (UCN 1) and UCN 2, inhibit gastric emptying and stimulate colonic motility through CRF2 and CRF1 receptors, respectively...
- Modulation of Ca2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cellsKazunori Kageyama
Department of Endocrinology, Metabolism and Infectious Diseases Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
Peptides 27:1814-9. 2006..of peptides are mediated by the seven transmembrane-domain G-protein-coupled receptors, the CRF receptors type 1 (CRF1 receptor) and type 2 (CRF2 receptor)...
- Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitisJennifer LaBerge
Dept of Anatomy, University of Vermont College of Medicine, Burlington, VT 05405, USA
Am J Physiol Regul Integr Comp Physiol 291:R692-703. 2006..CRF may contribute to urinary bladder overactivity and altered sensory processing with CYP-induced cystitis...
- Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulationRory J McCrimmon
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
J Clin Invest 116:1723-30. 2006..The corticotrophin-releasing factor (CRF) family of neuropeptides and their receptors (CRFR1 and CRFR2) play a critical role in regulating the neuroendocrine stress response...
- Lack of interaction between etifoxine and CRF1 and CRF2 receptors in rodentsMarc Verleye
Biocodex, Departement de Pharmacologie, Zac de Mercières, 60200 Compiegne, France
Neurosci Res 56:53-60. 2006..Blockade of CRF1 and CRF2 receptors can underlie the anxiolytic effects of drugs...
- The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded ratsElvan Djouma
Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia
Eur J Neurosci 23:3319-27. 2006..Furthermore, antalarmin, a selective corticotrophin-releasing factor type 1 (CRF1) receptor antagonist, reduces isolation-induced acquisition and maintenance of volitional ethanol consumption in ..
- Long-term potentiation (LTP) in the central amygdala (CeA) is enhanced after prolonged withdrawal from chronic cocaine and requires CRF1 receptorsYu Fu
Department of Pharmacology and Toxicology, Medical Branch, University of Texas, 301 University Blvd, Galveston, TX 77555 1031, USA
J Neurophysiol 97:937-41. 2007..We suggest that these signaling mechanisms may provide therapeutic targets for the treatment of cocaine cravings...
- Endocrine and behavioral effects of neuromedin SMiklós Jászberényi
Department of Pathophysiology, University of Szeged, H 6701, Szeged, Semmelweis u 1, PO Box 427, Hungary
Horm Behav 52:631-9. 2007..These results demonstrate that neuromedin S stimulates the HPA axis through the CRHR(1) pathway and evokes stereotyped behavior and anxiety through mesolimbic dopamine and corticotrophin releasing hormone release...
- Enhanced intracellular calcium induced by urocortin is involved in degranulation of rat lung mast cellsYuqing Wu
Department of Pharmacology, Nanjing Medical University, Nanjing, PR China
Cell Physiol Biochem 21:173-82. 2008..These findings may have implications for the pathophysiology of allergic and inflammatory lung disorders such as asthma, which is closely associated with mast cell activation and degranulation...
- Stimulation of the inferior olivary complex alters the distribution of the type 1 corticotropin releasing factor receptor in the adult rat cerebellar cortexJ B Tian
Department of Neuroscience, The Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
Neuroscience 153:308-17. 2008..These data suggest that CRF released from climbing fibers may modulate the physiological properties of basket and stellate cells as well as having a heretofore unidentified and potentially unique effect on Bergmann glia...
- Restraint stress increases serotonin release in the central nucleus of the amygdala via activation of corticotropin-releasing factor receptorsBing Mo
Biology Department and Neuroscience Group, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069, USA
Brain Res Bull 76:493-8. 2008..Furthermore, the results imply that corticotropin-releasing factor mediated serotonergic activity in central nucleus of the amygdala may be an important component of a stress response...
- The role of corticotrophin-releasing hormone receptors in the calcitonin gene-related peptide-induced suppression of pulsatile luteinising hormone secretion in the female ratJ E Bowe
Division of Reproduction and Endocrinology, New Hunt s House, King s College London, Guy s Campus, London, UK
Stress 11:312-9. 2008....
- Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) ratsNicholas W Gilpin
Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
Alcohol Clin Exp Res 32:1535-42. 2008....
- Corticotropin-releasing hormone receptor subtypes in the rat anterior pituitary after two types of restraint stressVera Klenerova
Laboratory of Biochemical Neuropharmacology, Institute of Medical Biochemistry, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
Ann N Y Acad Sci 1148:415-20. 2008..Our data demonstrated that these stressors did not change CRH-R2alpha mRNA, unlike the very significant response of CRH-R1 to IMO...
- Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2X Guan
Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
Neuroscience 161:665-70. 2009..Our data suggest that short-term cocaine withdrawal treatment may cause synaptic plasticity in hippocampus partially via changing the activity of CRF(2) in the hippocampus...
- Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic-pituitary-adrenal axis and induces anxiety-like behavior in adult male rat offspringJ M Fan
Division of Neurobiology and Physiology, College of Life Sciences, School of Medicine, Zhejiang University, Hangzhou, China
Neuroscience 159:1363-73. 2009..the stressors significantly and differentially increased CRH and corticotropin-releasing factor receptor type 1 (CRHR1) expression but decreased corticotropin-releasing factor receptor type 2 (CRHR2) in the paraventricular nucleus of ..
- CRF system recruitment mediates dark side of compulsive eatingPietro Cottone
Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, Harold L Dorris Neurological Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 106:20016-20. 2009....
- Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: differential effects of acute psychological and physical stressorsDervla O'Malley
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
Peptides 31:662-70. 2010..Immunofluorescent dual-labeling demonstrated increased activation of both CRFR1 (MS: 79.6+/-4.4% vs. NS: 43.8+/-6.8%, p<0.001) and CRFR2 (MS: 65.9+/-3.2% vs. NS: 51.6+/-5.8%, p<0...
- Swim stress differentially blocks CRF receptor mediated responses in dorsal raphe nucleusChristophe M Lamy
Anesthesiology and Division of Stress Neurobiology, Children s Hospital of Philadelphia Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Psychoneuroendocrinology 35:1321-32. 2010..These data provide a mechanism at the cellular level for the immobility induced by swim stress and identifies critical components of the raphe circuitry responsible for the altered output of 5-HT neurons induced by swim stress...
- Regulatory mechanism of hypothalamo-pituitary-adrenal (HPA) axis and neuronal changes after adrenalectomy in type 2 diabetesSun Shin Yi
Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151 742, South Korea
J Chem Neuroanat 40:130-9. 2010..Additionally, mRNA expression of AVP and CRH receptors (V1aR, V1bR, CRHR1, and CRHR2) was also measured and adrenocorticotropin hormone (ACTH) immunoreactivity was surveyed by IHC to add ..
- The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activityKatharina Schulz
Leibniz Institut fur Molekulare Pharmakologie, Robert Rossle Strasse 10, 13125 Berlin, Germany
J Biol Chem 285:32878-87. 2010..In the case of the corticotropin-releasing factor receptor subtypes, the use of conventional and pseudo signal peptides have an unexpected influence on signal transduction...
- Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptorsAutumn S Ivy
Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California 92697 4475, USA
J Neurosci 30:13005-15. 2010..Reducing CRF(1) occupancy post hoc normalized hippocampal function during middle age, thus offering potential mechanism-based therapeutic interventions for children affected by chronic stress...
- Differential effects of inescapable stress on locus coeruleus GRK3, alpha2-adrenoceptor and CRF1 receptor levels in learned helpless and non-helpless rats: a potential link to stress resilienceManish Taneja
Pcol and Pceu Sci, Univ Houston, Houston, TX, United States
Behav Brain Res 221:25-33. 2011..We suggest that reduced stress resilience after TSS may be related to oxidative stress, depletion of GRK3 and impaired regulation of α(2A)-AR and CRF(1)-R in LC...
- Stress and glucocorticoids regulated corticotropin releasing factor in rat prefrontal cortexQing Yuan Meng
CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Jinzhai Road 96, Hefei 230026, Anhui, PR China
Mol Cell Endocrinol 342:54-63. 2011..Specific attention was paid to the effect of CRF on CRF receptor 1 (CRFR1) expression in primary PFC cultures...
- Corticotropin-releasing hormone receptor-1 and 2 activity produces divergent resistance against stress-induced pulmonary Streptococcus pneumoniae infectionByung Jin Kim
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, United States
J Neuroimmunol 237:57-65. 2011..CRH receptor-mediated effects on immune responses could prove valuable for novel therapeutics...
- Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brainC P Chang
Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093 0648
Neuron 11:1187-95. 1993..Alternative splicing events generate a second, relatively abundant gene product expressed in a distinct ontogenic pattern. These findings serve to identify the receptor for an important neuropeptide...
- NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONSCatherine Rivier; Fiscal Year: 2004..Collectively, these results will provide novel and comprehensive information regarding the neurocircuitries through which NO or CO modulate the response of the rat HPA to a neurogenic stress. ..
- Role of AMPK in hypoglycemia-sensing in the ventromedial hypothalamusRORY MCCRIMMON; Fiscal Year: 2008..Finally, the proposal aims to obtain data that will support the hypothesis that recurrent hypoglycemia induces mitochondrial biogenesis in the VMH, an effect that may be mediated by AMPK. ..
- A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASECatherine Rivier; Fiscal Year: 2008..Collectively, these studies will advance our understanding of the effects of alcohol on male reproductive functions and the mechanisms that mediate them. ..