Crhr1

Summary

Gene Symbol: Crhr1
Description: corticotropin releasing hormone receptor 1
Alias: CRFR1, CRH-R 1, corticotropin-releasing factor receptor 1, CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRH-R-1, CRH-R1, corticotrophin releasing hormone receptor 1, corticotropin releasing hormone 1
Species: rat

Top Publications

  1. pmc Urocortin promotes the development of vasculitis in a rat model of thromboangiitis obliterans via corticotrophin-releasing factor type 1 receptors
    Youhua Xu
    Department of Pharmacology, Nanjing Medical University, Nanjing, China
    Br J Pharmacol 157:1368-79. 2009
  2. doi Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal
    Javier Navarro-Zaragoza
    Department of Pharmacology, University School of Medicine, University of Murcia, Murcia, Spain
    Mol Pharmacol 77:864-73. 2010
  3. ncbi Regulation of corticotropin-releasing factor (CRF) type-1 receptor gene expression by CRF in the hypothalamus
    Shun ichiro Konishi
    Department of Bioregulation, Institute of Gerontology, Nippon Medical School, Kawasaki 211 8533, Japan
    Endocr J 50:21-36. 2003
  4. ncbi Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 in human embryonic kidney 293 cells
    Doreen Wietfeld
    Institute of Molecular Pharmacology, Robert Rossle Strasse 10, Berlin 13125, Germany
    J Biol Chem 279:38386-94. 2004
  5. ncbi G protein-coupled receptor kinase 2 involvement in desensitization of corticotropin-releasing factor (CRF) receptor type 1 by CRF in murine corticotrophs
    Kazunori Kageyama
    Department of Endocrinology, Metabolism, and Infectious Diseases, Hirosaki University School of Medicine, Hirosaki, Aomori 036 8562, Japan
    Endocrinology 147:441-50. 2006
  6. doi Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats
    Muriel Larauche
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1033-40. 2008
  7. doi Involvement of microglial cells in infrasonic noise-induced stress via upregulated expression of corticotrophin releasing hormone type 1 receptor
    F Du
    Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, PR China
    Neuroscience 167:909-19. 2010
  8. ncbi Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans
    J Licinio
    Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Mol Psychiatry 9:1075-82. 2004
  9. ncbi The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology
    Edward W Hillhouse
    The Leeds Institute of Genetics, Health and Therapeutics, The University of Leeds, Leeds LS2 9NL, UK
    Endocr Rev 27:260-86. 2006
  10. pmc Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain-related synaptic facilitation and behavior
    Yu Fu
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurosci 28:3861-76. 2008

Research Grants

Scientific Experts

Detail Information

Publications112 found, 100 shown here

  1. pmc Urocortin promotes the development of vasculitis in a rat model of thromboangiitis obliterans via corticotrophin-releasing factor type 1 receptors
    Youhua Xu
    Department of Pharmacology, Nanjing Medical University, Nanjing, China
    Br J Pharmacol 157:1368-79. 2009
    ..Urocortin is a locally expressed pro-inflammatory peptide. Here we have examined the effects of urocortin on sodium laurate-induced peripheral arterial vasculitis in rats, modelling the mechanisms of thromboangiitis obliterans (TAO)...
  2. doi Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal
    Javier Navarro-Zaragoza
    Department of Pharmacology, University School of Medicine, University of Murcia, Murcia, Spain
    Mol Pharmacol 77:864-73. 2010
    ..However, CRF1R activation may not contribute to the functional interaction between NA and CRF systems in mediating morphine withdrawal-activation of brain stress neurocircuitry...
  3. ncbi Regulation of corticotropin-releasing factor (CRF) type-1 receptor gene expression by CRF in the hypothalamus
    Shun ichiro Konishi
    Department of Bioregulation, Institute of Gerontology, Nippon Medical School, Kawasaki 211 8533, Japan
    Endocr J 50:21-36. 2003
    ..These results demonstrate that CRF directly affects hypothalamic neurons to increase CRFR-1 mRNA expression, providing evidence of a direct role for CRF in the regulation of CRFR-1 expression of hypothalamic neurons...
  4. ncbi Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 in human embryonic kidney 293 cells
    Doreen Wietfeld
    Institute of Molecular Pharmacology, Robert Rossle Strasse 10, Berlin 13125, Germany
    J Biol Chem 279:38386-94. 2004
    ..Corresponding to a high and low affinity ligand binding site, sauvagine and other peptidic CRFR1 ligands evoked high and low potency responses of G protein activation, differing by 64-fold in their EC(50) values ..
  5. ncbi G protein-coupled receptor kinase 2 involvement in desensitization of corticotropin-releasing factor (CRF) receptor type 1 by CRF in murine corticotrophs
    Kazunori Kageyama
    Department of Endocrinology, Metabolism, and Infectious Diseases, Hirosaki University School of Medicine, Hirosaki, Aomori 036 8562, Japan
    Endocrinology 147:441-50. 2006
    Hypothalamic CRF stimulates synthesis and secretion of ACTH via CRF receptor type 1 (CRFR1) in the anterior pituitary gland. After agonist-activated stimulation of receptor signaling, CRFR1 is down-regulated and desensitized...
  6. doi Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats
    Muriel Larauche
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1033-40. 2008
    ..These data support a major role for CRF(1) in both the development and maintenance of visceral hyperalgesia induced by repeated stress and indicate a possible role of peripheral CRF receptors in such mechanisms...
  7. doi Involvement of microglial cells in infrasonic noise-induced stress via upregulated expression of corticotrophin releasing hormone type 1 receptor
    F Du
    Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, PR China
    Neuroscience 167:909-19. 2010
    ..These findings suggest that in addition to the PVN neurons, microglial cells are the effector cells for infrasound as well, and involve in the infrasound-induced stress through upregulated expression of CRH-R1...
  8. ncbi Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans
    J Licinio
    Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Mol Psychiatry 9:1075-82. 2004
    ..CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety...
  9. ncbi The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology
    Edward W Hillhouse
    The Leeds Institute of Genetics, Health and Therapeutics, The University of Leeds, Leeds LS2 9NL, UK
    Endocr Rev 27:260-86. 2006
    ..The type of activating agonist, receptor, and target cell appears to play a major role in determining the overall signaling and biological responses in health and disease...
  10. pmc Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain-related synaptic facilitation and behavior
    Yu Fu
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurosci 28:3861-76. 2008
    A major site of extrahypothalamic expression of corticotropin-releasing factor (CRF) and its G-protein-coupled CRF1 and CRF2 receptors is the amygdala, a key player in emotions and affective disorders...
  11. pmc Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathways
    Muriel Larauche
    CURE Digestive Diseases Research Center, Diseases Research Center, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 297:G215-27. 2009
    ..Stresslike colonic alterations induced by ip cortagine in rats and mice through restricted activation of peripheral CRF(1) receptors support a role for peripheral CRF(1) signaling as the local arm of the colonic response to stress...
  12. pmc CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axis
    Emily G Lowery
    Department of Psychology, University of North Carolina, Chapel Hill, NC, USA
    Neuropsychopharmacology 35:1241-52. 2010
    ..Furthermore, normal HPA axis signaling is not necessary to achieve binge-like drinking behavior...
  13. pmc Pain-related anxiety-like behavior requires CRF1 receptors in the amygdala
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 3:13. 2007
    Corticotropin-releasing factor receptor CRF1 has been implicated in the neurobiological mechanisms of anxiety and depression. The amygdala plays an important role in affective states and disorders such as anxiety and depression...
  14. ncbi Alterations in hypothalamic-pituitary-adrenal axis activity and in levels of proopiomelanocortin and corticotropin-releasing hormone-receptor 1 mRNAs in the pituitary and hypothalamus of the rat during chronic 'binge' cocaine and withdrawal
    Yan Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 964:187-99. 2003
    ....
  15. ncbi Corticotropin-releasing factor receptor types 1 and 2 are differentially expressed in pre- and post-synaptic elements in the post-natal developing rat cerebellum
    J D Swinny
    Laboratory for Cell Biology and Electron Microscopy, Department of Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Eur J Neurosci 18:549-62. 2003
    ..Finally, the distinct expression profiles of receptors along structural domains of Purkinje cells suggest that the role for these receptors is to modulate afferent inputs...
  16. ncbi Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Wellman 501, Boston, MA 02114 2696, USA
    FEBS Lett 579:803-7. 2005
    ..Fluphenazine, a calmodulin antagonist, enhances PTH-mediated accumulation of total inositol phosphates, suggesting that calmodulin regulates signaling via phospholipase C...
  17. pmc Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptor
    Kristina A Fenoglio
    Department of Anatomy Neurobiology, Med Sci I, ZOT 4475, University of California, Irvine, California 92697 4475, USA
    Endocrinology 146:4090-6. 2005
    ..Transient, partial selective blockade of CRF1 in nonhandled rats improved memory functions on both the Morris watermaze and object recognition tests to levels ..
  18. pmc Augmented cocaine seeking in response to stress or CRF delivered into the ventral tegmental area following long-access self-administration is mediated by CRF receptor type 1 but not CRF receptor type 2
    Jordan M Blacktop
    Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin 53201, USA
    J Neurosci 31:11396-403. 2011
    ..These findings reveal that excessive cocaine use increases susceptibility to stressor-induced relapse in part by augmenting CRF-R1-dependent regulation of addiction-related neurocircuitry in the VTA...
  19. pmc Anxiogenic effects of CGRP within the BNST may be mediated by CRF acting at BNST CRFR1 receptors
    K S Sink
    Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Center, Emory University, Atlanta, GA 30329, USA
    Behav Brain Res 243:286-93. 2013
    ..With this in mind, the present set of experiments was designed to examine the role of CRFR1 signaling in the anxiogenic effects of CGRP within the BNST and to determine whether CRF from BNST neurons ..
  20. doi Gestational hypoxia induces sex-differential methylation of Crhr1 linked to anxiety-like behavior
    Xi Wang
    Division of Neurobiology and Physiology, Department of Basic Medical Sciences, School of Medicine, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China
    Mol Neurobiol 48:544-55. 2013
    ..behavior in male P90 offspring and activation of corticotropin-releasing hormone (CRH) and CRH type-1 receptor (CRHR1) mRNA in the hypothalamic paraventricular nucleus (PVN) and in male E19 hypothalamus...
  21. pmc The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats
    Mulugeta Million
    CURE Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America Oppenheimer Family Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America
    PLoS ONE 8:e73749. 2013
    b>Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases...
  22. doi CRHR1 links peripuberty stress with deficits in social and stress-coping behaviors
    Vandana Veenit
    Laboratory of Behavioral Genetics, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    J Psychiatr Res 53:1-7. 2014
    ..The corticotropin releasing hormone (CRH) and the CRH receptor 1 (CRHR1) have been implicated in the link between early life adversity and adult anxiety and depression, with rodent ..
  23. doi Expression of urocortin and its receptors in the rat epididymis
    Adriana De Luca
    Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via Veterinaria 1, I 80137 Naples, Italy Electronic address
    Reprod Biol 14:140-7. 2014
    ..actions of CRH family peptides are mediated by two types of G-protein-coupled receptors, CRH type 1 receptor (CRHR1) and CRH type 2 receptor (CRHR2)...
  24. pmc Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome
    Maria M Buckley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland Department of Physiology, University College Cork, Cork, Ireland
    J Physiol 592:5235-50. 2014
    ..5 mg kg(-1) i.p) with or without the CRFR1 antagonist antalarmin (10 mg kg(-1) i.p)...
  25. ncbi Prenatal stress, anxiety and depression: a mechanism involving CRH peptide family
    Jun Ming Fan
    Division of Neurobiology and Physiology, Department of Basic Medical Sciences, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China
    Neuro Endocrinol Lett 35:429-39. 2014
    ..We present evidence demonstrating prenatal hypoxia exposure induced anxiety-like behavior in adult male rat offspring and CRHR1 in PVN of the hypothalamus is involved.
  26. doi Impaired miR449a-induced downregulation of Crhr1 expression in low-birth-weight rats
    Takahiro Nemoto
    Department of PhysiologyNippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    J Endocrinol 224:195-203. 2015
    ..NBW) offspring and impaired downregulation of corticotropin-releasing factor receptor type 1 (CRF-R1, Crhr1) in the anterior pituitary in restraint...
  27. doi Lifelong disturbance of serotonin transporter functioning results in fear learning deficits: Reversal by blockade of CRF1 receptors
    Elisabeth Y Bijlsma
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Brain Center Rudolf Magnus, Utrecht University, The Netherlands Electronic address
    Eur Neuropsychopharmacol 25:1733-43. 2015
    ..the known interactions between serotonin and corticotropin-releasing factor (CRF), we studied the effect of the CRFR1 antagonist CP154,526 on behavioral changes observed and determined CRF1 receptor levels in SERT(-/-) rats...
  28. ncbi Noise Stress-Induced Changes in mRNA Levels of Corticotropin-Releasing Hormone Family Molecules and Glucocorticoid Receptors in the Rat Brain
    E Eraslan
    Department of Physiology, Faculty of Veterinary Medicine, Istanbul University, Istanbul, Turkey
    Folia Biol (Praha) 61:66-73. 2015
    ....
  29. ncbi Corticotropin-releasing factor as well as opioid and dopamine are involved in tail-pinch-induced food intake of rats
    S Samarghandian
    Department of Physiology, Nippon Medical School, 1 1 5 Sendagi Bunkyo ku, Tokyo 113 8602, Japan
    Neuroscience 116:519-24. 2003
    ..The results also suggest that brain CRF has dual effects on food intake, hyperphagia and anorexia, in a stress-dependent manner...
  30. ncbi Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressors
    Catherine L Rivier
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Endocrinology 144:2396-403. 2003
    ..Finally, we showed that peripheral endogenous CRF restrains the ability of LPS to release cytokines...
  31. ncbi Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
    Marianne B Muller
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, Munich 80804, Germany
    Nat Neurosci 6:1100-7. 2003
    ..To differentiate the CNS pathways involving CRH and CRH receptor 1 (Crhr1) that modulate behavior from those that regulate neuroendocrine function, we generated a conditional knockout ..
  32. ncbi CRF receptor type 1 and 2 expression and anatomical distribution in the rat colon
    Ekaterini Chatzaki
    Neurocrine Biosciences Inc, San Diego, CA 92121, USA
    J Neurochem 90:309-16. 2004
    ..These results demonstrate expression of both CRF receptor types in the rat colon and support a role for their involvement in regulating peripheral effects of CRF ligands...
  33. pmc The signal peptide of the rat corticotropin-releasing factor receptor 1 promotes receptor expression but is not essential for establishing a functional receptor
    Martina Alken
    Forschungsinstitut für Molekulare Pharmakologie FMP, Robert Rossle Str 10, 13125 Berlin, Germany
    Biochem J 390:455-64. 2005
    ..Thus the signal peptide of the CRF-R1 promotes an early step of receptor biogenesis, such as targeting of the nascent chain to the ER membrane and/or the gating of the protein-conducting translocon of the ER membrane...
  34. ncbi Differential role of corticotrophin-releasing factor receptor types 1 and 2 in stress-induced suppression of pulsatile luteinising hormone secretion in the female rat
    X F Li
    Division of Reproductive Health, Endocrinology and Development, King s College London, Guy s Campus, London, UK
    J Neuroendocrinol 18:602-10. 2006
    ..These results suggest that hypoglycaemia and LPS stress-induced LH suppression involves activation of CRF(2) while restraint stress-induced inhibition of LH pulses involves both CRF(1) and CRF(2)...
  35. ncbi Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation
    Haiying Cheng
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Endocrinol Metab 293:E705-12. 2007
    ..The VMH expresses both subtypes of CRF receptors, CRFR1 and CRFR2...
  36. pmc Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens
    Jodi L Lukkes
    Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069 2390, USA
    Eur J Pharmacol 578:185-93. 2008
    ..These results suggest that the opposing effects of dorsal raphé CRF on 5-HT release in the nucleus accumbens are dependent on differential activation of CRF(1) and CRF(2) receptors in the dorsal raphé nucleus...
  37. ncbi Corticotropin-releasing hormone (CRH) depresses n-methyl-D-aspartate receptor-mediated current in cultured rat hippocampal neurons via CRH receptor type 1
    Hui Sheng
    Department of Physiology, Ministry of Education, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 149:1389-98. 2008
    ..This effect was reversed by the CRH receptor type 1 (CRHR1) antagonist antalarmin but not by the CRHR2 antagonist astressin-2B, suggesting that CRHR1 mediated the inhibitory ..
  38. doi Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD
    Woo J Kim
    Department of Internal Medicine, College of Medicine, Kangwon National University, Chuncheon, Korea
    Respirology 14:260-3. 2009
    ..An association between sequence variants in the corticotrophin-releasing hormone receptor 1 (CRHR1) gene and improved lung function in asthmatics treated with inhaled corticosteroids was reported recently...
  39. ncbi Neonatal maternal separation elevates thalamic corticotrophin releasing factor type 1 receptor expression response to colonic distension in rat
    Yung Wui Tjong
    School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, China
    Neuro Endocrinol Lett 31:215-20. 2010
    ..The aim of our study is to examine the effect of neonatal maternal separation (NMS), an early life stress model, on the brain CRF expression following visceral pain induced by colorectal distension (CRD) stimuli in male rats...
  40. doi Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders
    Javier A Bravo
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Int J Neuropsychopharmacol 14:666-83. 2011
    ..Corticotrophin-releasing factor (CRF) is the primary peptide regulating this axis, acting through two receptors: CRF1 and CRF2. The central CRF system is also a key regulator in the stress response...
  41. doi Peripheral corticotropin-releasing factor (CRF) induces stimulation of gastric contractions in freely moving conscious rats: role of CRF receptor types 1 and 2
    T Nozu
    Department of Regional Medicine and Education, Asahikawa Medical University, Asahikawa, Japan
    Neurogastroenterol Motil 25:190-7. 2013
    ..CRF injected peripherally inhibits gastric emptying, but its effect on gastric contractions has not been clarified in freely moving conscious rats...
  42. doi Water-avoidance stress enhances gastric contractions in freely moving conscious rats: role of peripheral CRF receptors
    Tsukasa Nozu
    Department of Regional Medicine and Education, Asahikawa Medical University, Midorigaoka Higashi 2 1 1 1, Asahikawa, 078 8510, Japan
    J Gastroenterol 49:799-805. 2014
    ..involved in the regulation of gastric motility, and enhances gastric contractions through CRF receptor type 1 (CRF1) and delays gastric emptying (GE) through CRF receptor type 2 (CRF2)...
  43. doi Individual differences in the immobility behavior in juvenile and adult rats are associated with monoaminergic neurotransmission and with the expression of corticotropin-releasing factor receptor 1 in the nucleus accumbens
    Andrey Sequeira-Cordero
    Instituto de Investigaciones en Salud, Universidad de Costa Rica, 11501 2060 San Pedro, San Jose, Costa Rica
    Behav Brain Res 252:77-87. 2013
    ..Moreover, the expression of accumbal corticotrophin-releasing factor receptor 1 (CRFR1) was significantly different in animals with low and high immobility at both ages, with animals less immobile ..
  44. pmc Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats
    Ami Cohen
    The Scripps Research Institute, La Jolla, CA, USA
    Addict Biol 20:56-68. 2015
    ..Here, we tested the hypothesis that the activation of corticotropin-releasing factor-1 (CRF1 ) receptors and emergence of the affective and motivational effects of nicotine abstinence only occur in rats with ..
  45. pmc Predator odor stress alters corticotropin-releasing factor-1 receptor (CRF1R)-dependent behaviors in rats
    Emily A Roltsch
    Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA, USA Electronic address
    Neuropharmacology 79:83-9. 2014
    ..These results suggest that post-stress alcohol drinking may be driven by a high-nociception high-arousal state, and that brain CRF1R signaling mediates these stress effects. ..
  46. doi Histone modifications of the Crhr1 gene in a rat model of depression following chronic stress
    Qirong Wan
    Department of Psychiatry, Renmin Hospital, Wuhan University, Jiefang Road 238, Wuhan 430060, PR China
    Behav Brain Res 271:1-6. 2014
    ..of the corticotrophin-releasing hormone (CRH) and its main receptor, corticotrophin-releasing hormone receptor 1 (CRHR1). However, the precise molecular mechanisms underlying depression remain poorly understood...
  47. pmc Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats
    Andrea Cippitelli
    Pharmacology Unit, School of Pharmacy, University of Camerino, Building of Experimental Medicine, Via Madonna delle Carceri, Camerino, MC, 62032, Italy
    Psychopharmacology (Berl) 232:1083-93. 2015
    ..In these animals, two single-nucleotide polymorphisms in position -1,836 and -2,097 from the first start codon of the CRF1-R transcript have been found.
  48. pmc Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivo
    Simeon J Ramsey
    Discovery Biology, Pfizer, Kent, UK
    Br J Pharmacol 164:992-1007. 2011
    ....
  49. pmc Prevention of social stress-escalated cocaine self-administration by CRF-R1 antagonist in the rat VTA
    Christopher O Boyson
    Department of Psychology, Tufts University, Medford, MA, USA
    Psychopharmacology (Berl) 218:257-69. 2011
    ..Stressful encounters can lead to activation of dopamine neurons in the ventral tegmental area (VTA), which are modulated by corticotropin releasing factor (CRF) neurons...
  50. doi Effects of acute stress on acquisition of nicotine conditioned place preference in adolescent rats: a role for corticotropin-releasing factor 1 receptors
    Jennifer Brielmaier
    Department of Psychology, George Mason University, Fairfax, VA 22030, USA
    Psychopharmacology (Berl) 219:73-82. 2012
    ..Corticotropin-releasing factor type 1 receptors (CRF-R1) mediate physiological and behavioral stress responses. They may also mediate stress-induced potentiation of activity in multiple neural substrates implicated in nicotine reward...
  51. doi R278995/CRA0450, a corticotropin-releasing factor (CRF(1)) receptor antagonist modulates REM sleep measures in rats: Implication for therapeutic indication
    Abdallah Ahnaou
    Janssen Research and Development, Dept of Neurosciences, Johnson and Johnson Pharmaceutical Companies, Turnhoutseweg 30, B 2340 Beerse, Belgium
    Eur J Pharmacol 680:63-8. 2012
    ..The characteristic changes found in the sleep EEG model further support the hypothesis that R278995/CRA0450 could exert a non-sedative, antidepressant-like action...
  52. pmc A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis
    Erin N McDowell
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, Delaware, United States of America
    PLoS ONE 7:e47359. 2012
    ..Fetal mouse testis interstitial expression of a subset of these genes with unknown expression (Crhr1, Gramd1b, Itih5, Vgll3, and Vsnl1) was verified by whole-mount in situ hybridization...
  53. doi Upregulation of PVN CRHR1 by gestational intermittent hypoxia selectively triggers a male-specific anxiogenic effect in rat offspring
    Jun Ming Fan
    Division of Neurobiology and Physiology, Department of Basic Medical Sciences, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310027, China
    Horm Behav 63:25-31. 2013
    ..showed that the anxiogenic effect was correlated with upregulation of corticotropin-releasing hormone receptor 1 (CRHR1) in the hypothalamic paraventricular nuclei (PVN) by GIH, and was selective to male offspring...
  54. pmc Non-pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responses
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1069, USA
    Mol Pain 9:2. 2013
    ..Our previous studies showed that endogenous activation of CRF1 receptors in an arthritis pain model contributes to amygdala hyperactivity and pain-related behaviors...
  55. ncbi The use of H-2 mutants as models for the study of T cell activation
    I F McKenzie
    Immunol Rev 35:179-230. 1977
  56. ncbi Cloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptor
    M H Perrin
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, CA 92037
    Endocrinology 133:3058-61. 1993
    ..The receptor transduces a CRF stimulated accumulation of intracellular cAMP which is inhibited by the CRF antagonist, alpha helCRF(9-41). These results suggest that the brain expresses a CRF receptor similar to that in the pituitary...
  57. ncbi The genomic structure of the rat corticotropin releasing factor receptor. A member of the class II G protein-coupled receptors
    C H Tsai-Morris
    Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Biol Chem 271:14519-25. 1996
    ....
  58. ncbi Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior
    S C Heinrichs
    Neurocrine Biosciences, Inc, San Diego, CA 92121, USA
    Regul Pept 71:15-21. 1997
    ..differential localization in brain of three binding sites for corticotropin-releasing factor (CRF)-like peptides (CRF1 and CRF2 receptors as well as CRF-binding protein) suggest the existence of functionally distinct neurobiological ..
  59. ncbi Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin
    J Gottowik
    Pharma Division, F Hoffmann La Roche Ltd, Basel, Switzerland
    Neuropharmacology 36:1439-46. 1997
    ..3H]-rat urocortin to homogenates of rat cerebellum and homogenates of cells stably transfected with the human CRF1, rat CRF2alpha and rat CRF2beta receptors was examined...
  60. ncbi Antalarmin blockade of corticotropin releasing hormone-induced hypertension in rats
    R J Briscoe
    Department of Pharmacology, University of Michigan, 48109, Ann Arbor, MI, USA
    Brain Res 881:204-7. 2000
    ..of antalarmin, a novel, small molecule CRH1 receptor antagonist, and alpha-helical CRH(9-41), a peptidic CRHR1/CRHR2 antagonist to attempt to determine the receptor mechanisms through which CRH is acting in both of these ..
  61. pmc Functional and protein chemical characterization of the N-terminal domain of the rat corticotropin-releasing factor receptor 1
    B A Hofmann
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, D 37073 Gottingen, Germany
    Protein Sci 10:2050-62. 2001
    ..Of all putative N-glycosylation sites in positions 32, 38, 45, 78, 90, and 98, all Asn residues except for Asn(32) were glycosylated to a significant extent. No O-glycosylation was observed...
  62. ncbi Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors
    Inge Sillaber
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Science 296:931-3. 2002
    ..Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism...
  63. ncbi Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemia
    Daniel E Flanagan
    Section of Endocrinology, Yale University School of Medicine, New Haven, CT 06520, USA
    Diabetes 52:605-13. 2003
    ..004). The addition of a CRH receptor 1 (CRHr1) antagonist to the antecedent CRH reversed the subsequent suppression of epinephrine...
  64. ncbi Corticotropin-releasing factor receptor type 1 is involved in the stress-induced exacerbation of chronic contact dermatitis in rats
    Katsumi Kaneko
    Department of Physiology, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Exp Dermatol 12:47-52. 2003
    ..a 1-h period of electric foot-shock following intraperitoneal administration of CRA1000, a selective CRFR type 1 (CRFR1) antagonist, or vehicle everyday for 9 days...
  65. ncbi Stimulation of neurons in rat ARC inhibits gastric acid secretion via hypothalamic CRF1/2- and NPY-Y1 receptors
    Johannes J Tebbe
    Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Philipps Universitat Marburg, 35033 Marburg, Germany
    Am J Physiol Gastrointest Liver Physiol 285:G1075-83. 2003
    ..study, we performed consecutive bilateral microinjections of antagonists to NPY receptor subtypes Y1 and Y2 and to CRF1/2 receptors in the PVN and of the excitatory amino acid kainate in the ARC to assess the role of NPY- and CRF-..
  66. ncbi Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin
    Alexandra Wigger
    Max Planck Institute of Psychiatry, Behavioural Neuroendocrinology, Munich, Germany
    Neuropsychopharmacology 29:1-14. 2004
    ....
  67. ncbi Anorectic actions of prolactin-releasing peptide are mediated by corticotropin-releasing hormone receptors
    Catherine B Lawrence
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 286:R101-7. 2004
    ..These results show that the anorectic actions of PrRP are mediated by central CRH receptors but not by melanocortin receptors-3/4 and that PrRP can modify Vo2...
  68. ncbi The effect of chronic CRF1 receptor blockade on the central CCK systems of Fawn-Hooded rats
    Daniel J Lodge
    Department of Pharmacology, Monash University, Box 13E, Clayton, Victoria 3800, Australia
    Regul Pept 116:27-33. 2003
    ..Therefore, these data provide clear evidence of the ability of chronic CRF(1) receptor blockade to significantly influence the central CCK systems of the rat...
  69. ncbi Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians
    B G Challis
    University Departments of Medicine and Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes Relat Metab Disord 28:442-6. 2004
    ..To investigate whether genetic variation at the loci encoding the corticotropin-releasing factor receptors-1 and -2 (CRF-R1 and CRF-R2) contributes to human obesity...
  70. ncbi Regulation of pituitary corticotropin releasing factor type-1 receptor mRNA binding proteins by modulation of the hypothalamic-pituitary-adrenal axis
    Z Wu
    Center for the Study of Sex Differences, Georgetown University, Washington, DC 20057, USA
    J Neuroendocrinol 16:214-20. 2004
    ..The data suggest that CRF-R1 translation is regulated by modulation of the HPA axis through pituitary cytosolic proteins binding to the CRF-R1 5'LS...
  71. pmc Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus
    Heidi E W Day
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
    J Comp Neurol 474:364-78. 2004
    ..The differential distribution of distinct neurochemical phenotypes lends support to the idea of functional differentiation of the DR...
  72. ncbi CRH receptor type 1 mediates continual hypoxia-induced changes of immunoreactive prolactin and prolactin mRNA expression in rat pituitary
    Jian Fen Xu
    Division of Neurobiology and Physiology, College of Life Sciences, Zhejiang University, Yuquan Campus, Hangzhou 310027, PR China
    Horm Behav 49:181-9. 2006
    ..This study also investigates the involvement of the corticotropin-releasing hormone receptor 1 (CRH R1) in the hypoxia-induced PRL response. Hypoxia was induced by exposing the rats to high altitudes of 2 km (16...
  73. ncbi Corticotropin-releasing factor receptor subtype 1 and somatostatin modulating hypoxia-caused downregulated mRNA of pituitary growth hormone and upregulated mRNA of hepatic insulin-like growth factor-I of rats
    Xue Qun Chen
    Division of Neurobiology and Physiology, College of Life Sciences, Zhejiang University Yuquan Campus, Hangzhou 310027, China
    Mol Cell Endocrinol 242:50-8. 2005
    ..mRNA and its protein in rats, and the potential involvement of corticotropin-releasing factor receptor subtype 1 (CRFR1) and SS in mediating the effects of continual hypoxia. Continual or intermittent hypoxia of 5 km (10...
  74. ncbi Differential regulation of corticotropin-releasing factor receptor type 1 (CRF1 receptor) mRNA via protein kinase A and mitogen-activated protein kinase pathways in rat anterior pituitary cells
    Takako Moriyama
    The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Aomori 036 8562, Japan
    Mol Cell Endocrinol 243:74-9. 2005
    ..These results suggested that in the rat AP, down-regulation of CRF(1) receptor mRNA levels is caused by mRNA degradation via PKA, but not by the MAP kinase pathway...
  75. ncbi Photoaffinity cross-linking of the corticotropin-releasing factor receptor type 1 with photoreactive urocortin analogues
    Oliver Kraetke
    Department of Peptide Chemistry, Institute of Molecular Pharmacology FMP, 13125 Berlin, Germany
    Biochemistry 44:15569-77. 2005
    ....
  76. ncbi Endogenous expression and in vitro study of CRF-related peptides and CRF receptors in the rat gastric antrum
    Christophe Porcher
    Groupe d Etude du Stress et des Interactions Neuro Digestives GESIND, EA3744, CHRU Grenoble, BP 217, Grenoble 38043, France
    Peptides 27:1464-75. 2006
    ..peptides, urocortin 1 (UCN 1) and UCN 2, inhibit gastric emptying and stimulate colonic motility through CRF2 and CRF1 receptors, respectively...
  77. ncbi Modulation of Ca2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cells
    Kazunori Kageyama
    Department of Endocrinology, Metabolism and Infectious Diseases Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Peptides 27:1814-9. 2006
    ..of peptides are mediated by the seven transmembrane-domain G-protein-coupled receptors, the CRF receptors type 1 (CRF1 receptor) and type 2 (CRF2 receptor)...
  78. ncbi Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitis
    Jennifer LaBerge
    Dept of Anatomy, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Regul Integr Comp Physiol 291:R692-703. 2006
    ..CRF may contribute to urinary bladder overactivity and altered sensory processing with CYP-induced cystitis...
  79. pmc Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation
    Rory J McCrimmon
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    J Clin Invest 116:1723-30. 2006
    ..The corticotrophin-releasing factor (CRF) family of neuropeptides and their receptors (CRFR1 and CRFR2) play a critical role in regulating the neuroendocrine stress response...
  80. ncbi Lack of interaction between etifoxine and CRF1 and CRF2 receptors in rodents
    Marc Verleye
    Biocodex, Departement de Pharmacologie, Zac de Mercières, 60200 Compiegne, France
    Neurosci Res 56:53-60. 2006
    ..Blockade of CRF1 and CRF2 receptors can underlie the anxiolytic effects of drugs...
  81. ncbi The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded rats
    Elvan Djouma
    Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia
    Eur J Neurosci 23:3319-27. 2006
    ..Furthermore, antalarmin, a selective corticotrophin-releasing factor type 1 (CRF1) receptor antagonist, reduces isolation-induced acquisition and maintenance of volitional ethanol consumption in ..
  82. ncbi Long-term potentiation (LTP) in the central amygdala (CeA) is enhanced after prolonged withdrawal from chronic cocaine and requires CRF1 receptors
    Yu Fu
    Department of Pharmacology and Toxicology, Medical Branch, University of Texas, 301 University Blvd, Galveston, TX 77555 1031, USA
    J Neurophysiol 97:937-41. 2007
    ..We suggest that these signaling mechanisms may provide therapeutic targets for the treatment of cocaine cravings...
  83. ncbi Endocrine and behavioral effects of neuromedin S
    Miklós Jászberényi
    Department of Pathophysiology, University of Szeged, H 6701, Szeged, Semmelweis u 1, PO Box 427, Hungary
    Horm Behav 52:631-9. 2007
    ..These results demonstrate that neuromedin S stimulates the HPA axis through the CRHR(1) pathway and evokes stereotyped behavior and anxiety through mesolimbic dopamine and corticotrophin releasing hormone release...
  84. doi Enhanced intracellular calcium induced by urocortin is involved in degranulation of rat lung mast cells
    Yuqing Wu
    Department of Pharmacology, Nanjing Medical University, Nanjing, PR China
    Cell Physiol Biochem 21:173-82. 2008
    ..These findings may have implications for the pathophysiology of allergic and inflammatory lung disorders such as asthma, which is closely associated with mast cell activation and degranulation...
  85. doi Stimulation of the inferior olivary complex alters the distribution of the type 1 corticotropin releasing factor receptor in the adult rat cerebellar cortex
    J B Tian
    Department of Neuroscience, The Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
    Neuroscience 153:308-17. 2008
    ..These data suggest that CRF released from climbing fibers may modulate the physiological properties of basket and stellate cells as well as having a heretofore unidentified and potentially unique effect on Bergmann glia...
  86. pmc Restraint stress increases serotonin release in the central nucleus of the amygdala via activation of corticotropin-releasing factor receptors
    Bing Mo
    Biology Department and Neuroscience Group, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069, USA
    Brain Res Bull 76:493-8. 2008
    ..Furthermore, the results imply that corticotropin-releasing factor mediated serotonergic activity in central nucleus of the amygdala may be an important component of a stress response...
  87. doi The role of corticotrophin-releasing hormone receptors in the calcitonin gene-related peptide-induced suppression of pulsatile luteinising hormone secretion in the female rat
    J E Bowe
    Division of Reproduction and Endocrinology, New Hunt s House, King s College London, Guy s Campus, London, UK
    Stress 11:312-9. 2008
    ....
  88. pmc Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats
    Nicholas W Gilpin
    Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 32:1535-42. 2008
    ....
  89. doi Corticotropin-releasing hormone receptor subtypes in the rat anterior pituitary after two types of restraint stress
    Vera Klenerova
    Laboratory of Biochemical Neuropharmacology, Institute of Medical Biochemistry, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Ann N Y Acad Sci 1148:415-20. 2008
    ..Our data demonstrated that these stressors did not change CRH-R2alpha mRNA, unlike the very significant response of CRH-R1 to IMO...
  90. doi Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2
    X Guan
    Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
    Neuroscience 161:665-70. 2009
    ..Our data suggest that short-term cocaine withdrawal treatment may cause synaptic plasticity in hippocampus partially via changing the activity of CRF(2) in the hippocampus...
  91. doi Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic-pituitary-adrenal axis and induces anxiety-like behavior in adult male rat offspring
    J M Fan
    Division of Neurobiology and Physiology, College of Life Sciences, School of Medicine, Zhejiang University, Hangzhou, China
    Neuroscience 159:1363-73. 2009
    ..the stressors significantly and differentially increased CRH and corticotropin-releasing factor receptor type 1 (CRHR1) expression but decreased corticotropin-releasing factor receptor type 2 (CRHR2) in the paraventricular nucleus of ..
  92. pmc CRF system recruitment mediates dark side of compulsive eating
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, Harold L Dorris Neurological Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20016-20. 2009
    ....
  93. doi Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: differential effects of acute psychological and physical stressors
    Dervla O'Malley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Peptides 31:662-70. 2010
    ..Immunofluorescent dual-labeling demonstrated increased activation of both CRFR1 (MS: 79.6+/-4.4% vs. NS: 43.8+/-6.8%, p<0.001) and CRFR2 (MS: 65.9+/-3.2% vs. NS: 51.6+/-5.8%, p<0...
  94. pmc Swim stress differentially blocks CRF receptor mediated responses in dorsal raphe nucleus
    Christophe M Lamy
    Anesthesiology and Division of Stress Neurobiology, Children s Hospital of Philadelphia Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Psychoneuroendocrinology 35:1321-32. 2010
    ..These data provide a mechanism at the cellular level for the immobility induced by swim stress and identifies critical components of the raphe circuitry responsible for the altered output of 5-HT neurons induced by swim stress...
  95. doi Regulatory mechanism of hypothalamo-pituitary-adrenal (HPA) axis and neuronal changes after adrenalectomy in type 2 diabetes
    Sun Shin Yi
    Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151 742, South Korea
    J Chem Neuroanat 40:130-9. 2010
    ..Additionally, mRNA expression of AVP and CRH receptors (V1aR, V1bR, CRHR1, and CRHR2) was also measured and adrenocorticotropin hormone (ACTH) immunoreactivity was surveyed by IHC to add ..
  96. pmc The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity
    Katharina Schulz
    Leibniz Institut fur Molekulare Pharmakologie, Robert Rossle Strasse 10, 13125 Berlin, Germany
    J Biol Chem 285:32878-87. 2010
    ..In the case of the corticotropin-releasing factor receptor subtypes, the use of conventional and pseudo signal peptides have an unexpected influence on signal transduction...
  97. pmc Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors
    Autumn S Ivy
    Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California 92697 4475, USA
    J Neurosci 30:13005-15. 2010
    ..Reducing CRF(1) occupancy post hoc normalized hippocampal function during middle age, thus offering potential mechanism-based therapeutic interventions for children affected by chronic stress...
  98. pmc Differential effects of inescapable stress on locus coeruleus GRK3, alpha2-adrenoceptor and CRF1 receptor levels in learned helpless and non-helpless rats: a potential link to stress resilience
    Manish Taneja
    Pcol and Pceu Sci, Univ Houston, Houston, TX, United States
    Behav Brain Res 221:25-33. 2011
    ..We suggest that reduced stress resilience after TSS may be related to oxidative stress, depletion of GRK3 and impaired regulation of α(2A)-AR and CRF(1)-R in LC...
  99. doi Stress and glucocorticoids regulated corticotropin releasing factor in rat prefrontal cortex
    Qing Yuan Meng
    CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Jinzhai Road 96, Hefei 230026, Anhui, PR China
    Mol Cell Endocrinol 342:54-63. 2011
    ..Specific attention was paid to the effect of CRF on CRF receptor 1 (CRFR1) expression in primary PFC cultures...
  100. doi Corticotropin-releasing hormone receptor-1 and 2 activity produces divergent resistance against stress-induced pulmonary Streptococcus pneumoniae infection
    Byung Jin Kim
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, United States
    J Neuroimmunol 237:57-65. 2011
    ..CRH receptor-mediated effects on immune responses could prove valuable for novel therapeutics...
  101. ncbi Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain
    C P Chang
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093 0648
    Neuron 11:1187-95. 1993
    ..Alternative splicing events generate a second, relatively abundant gene product expressed in a distinct ontogenic pattern. These findings serve to identify the receptor for an important neuropeptide...

Research Grants3

  1. NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONS
    Catherine Rivier; Fiscal Year: 2004
    ..Collectively, these results will provide novel and comprehensive information regarding the neurocircuitries through which NO or CO modulate the response of the rat HPA to a neurogenic stress. ..
  2. Role of AMPK in hypoglycemia-sensing in the ventromedial hypothalamus
    RORY MCCRIMMON; Fiscal Year: 2008
    ..Finally, the proposal aims to obtain data that will support the hypothesis that recurrent hypoglycemia induces mitochondrial biogenesis in the VMH, an effect that may be mediated by AMPK. ..
  3. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2008
    ..Collectively, these studies will advance our understanding of the effects of alcohol on male reproductive functions and the mechanisms that mediate them. ..