Creb1

Summary

Gene Symbol: Creb1
Description: cAMP responsive element binding protein 1
Alias: Creb, cyclic AMP-responsive element-binding protein 1, CREB-1, Y protein, cAMP response element binding protein 1
Species: rat

Top Publications

  1. ncbi CREB modulates excitability of nucleus accumbens neurons
    Yan Dong
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304, USA
    Nat Neurosci 9:475-7. 2006
  2. doi Impaired spatial learning related with decreased expression of calcium/calmodulin-dependent protein kinase IIalpha and cAMP-response element binding protein in the pentylenetetrazol-kindled rats
    Pei Wang
    Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, PR China
    Brain Res 1238:108-17. 2008
  3. ncbi Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells
    Jan Lynge
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sports Sciences, August Krogh Institute, Copenhagen University, Universitetsparken 13, Copenhagen Ø, DK 2100, Denmark
    Biochem Biophys Res Commun 307:180-7. 2003
  4. pmc Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvement
    Sophia T Papadeas
    Neurobiology Curriculum, Department of Psychiatry and University of North Carolina Neuroscience Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    J Neurosci 24:5863-76. 2004
  5. doi VEGF-A/VEGFR-2 signaling leading to cAMP response element-binding protein phosphorylation is a shared pathway underlying the protective effect of preconditioning on neurons and endothelial cells
    Hsueh Te Lee
    Department of Pediatrics, Institute of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    J Neurosci 29:4356-68. 2009
  6. ncbi CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases
    M Sheng
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115
    Science 252:1427-30. 1991
  7. ncbi CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    S Herzig
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nature 413:179-83. 2001
  8. ncbi Phosphorylated cyclic AMP response element binding protein expression induced in the periaqueductal gray by predator stress: its relationship to the stress experience, behavior and limbic neural plasticity
    Robert E Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, A1B 3X9, St John s, Newfoundland, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:1243-67. 2003
  9. ncbi IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB
    Carola Maldonado
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago
    Biochem Biophys Res Commun 336:1112-8. 2005
  10. ncbi Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement
    K H Choi
    Department of Psychiatry, Seay Center for Basic and Applied Research in Psychiatric Illness, University of Texas Southwestern Medical Center, Dallas, 75390 9070, USA
    Neuroscience 137:373-83. 2006

Scientific Experts

Detail Information

Publications138 found, 100 shown here

  1. ncbi CREB modulates excitability of nucleus accumbens neurons
    Yan Dong
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304, USA
    Nat Neurosci 9:475-7. 2006
    Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc)...
  2. doi Impaired spatial learning related with decreased expression of calcium/calmodulin-dependent protein kinase IIalpha and cAMP-response element binding protein in the pentylenetetrazol-kindled rats
    Pei Wang
    Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, PR China
    Brain Res 1238:108-17. 2008
    ..of calcium/calmodulin-dependent protein kinase IIalpha (CaMKII(alpha)) and cAMP-response element binding protein (CREB) in hippocampus of those rats using western blot and reverse transcription-polymerase chain reaction (RT-PCR)...
  3. ncbi Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells
    Jan Lynge
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sports Sciences, August Krogh Institute, Copenhagen University, Universitetsparken 13, Copenhagen Ø, DK 2100, Denmark
    Biochem Biophys Res Commun 307:180-7. 2003
    ..NECA resulted in phosphorylation of CREB with an EC(50) of (95% confidence interval)=1.7 (0.40-7...
  4. pmc Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvement
    Sophia T Papadeas
    Neurobiology Curriculum, Department of Psychiatry and University of North Carolina Neuroscience Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    J Neurosci 24:5863-76. 2004
    ..Phosphorylated cAMP response element-binding protein (CREB), examined 7 d after the sensitizing regimen, was observed exclusively in MPC, where it was abundant throughout all ..
  5. doi VEGF-A/VEGFR-2 signaling leading to cAMP response element-binding protein phosphorylation is a shared pathway underlying the protective effect of preconditioning on neurons and endothelial cells
    Hsueh Te Lee
    Department of Pediatrics, Institute of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    J Neurosci 29:4356-68. 2009
    ..of the 24 h artery ligation preconditioning model requires the activation of cAMP response element-binding protein (CREB)...
  6. ncbi CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases
    M Sheng
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115
    Science 252:1427-30. 1991
    ..The adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB) was shown to function as a Ca(2+)-regulated transcription factor and as a substrate for depolarization-activated ..
  7. ncbi CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    S Herzig
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nature 413:179-83. 2001
    ..Here we show that mice carrying a targeted disruption of the cyclic AMP (cAMP) response element binding (CREB) protein gene, or overexpressing a dominant-negative CREB inhibitor, exhibit fasting hypoglycaemia [corrected] and ..
  8. ncbi Phosphorylated cyclic AMP response element binding protein expression induced in the periaqueductal gray by predator stress: its relationship to the stress experience, behavior and limbic neural plasticity
    Robert E Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, A1B 3X9, St John s, Newfoundland, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:1243-67. 2003
    ..Finally, consistent with cat and human studies, the right hemisphere appears particularly important in long-term response to stress...
  9. ncbi IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB
    Carola Maldonado
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago
    Biochem Biophys Res Commun 336:1112-8. 2005
    ..IGF-1 induces intracellular Ca(2+) increase, we assessed whether the cyclic AMP response element-binding protein (CREB) is activated by IGF-1 through Ca(2+)-dependent signalling pathways...
  10. ncbi Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement
    K H Choi
    Department of Psychiatry, Seay Center for Basic and Applied Research in Psychiatric Illness, University of Texas Southwestern Medical Center, Dallas, 75390 9070, USA
    Neuroscience 137:373-83. 2006
    ..cyclic AMP signaling and increases the transcriptional activity of cyclic AMP response element binding protein (CREB) in the nucleus accumbens...
  11. ncbi D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex
    Maïté Hotte
    INSERM, U796, Pathophysiology of Psychiatric Disorders, University Paris Descartes, Faculty of Medecine Paris Descartes, France
    Behav Brain Res 171:127-33. 2006
    ..We analyzed the level of phosphorylation of both CREB (cAMP response element binding protein) and DARPP-32 (dopamine and cAMP-regulated phosphoprotein, 32 kDa) in (1) ..
  12. ncbi Elevated pCREB in the PAG after exposure to the elevated plus maze in rats previously exposed to a cat
    Jacqueline Blundell
    Department of Psychology, Memorial University of Newfoundland and Labrador, St John s, Nfld, Canada A1B 3X9
    Behav Brain Res 175:285-95. 2006
    ..If what happens in animals also occurs in humans, the findings of this study suggest that neural mechanisms of prior traumatic stress may interact with subsequent stress to reinforce psychopathology...
  13. ncbi PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation
    Joseph Peltier
    Department of Chemical Engineering, University of California, Berkeley, California 94720, USA
    Dev Neurobiol 67:1348-61. 2007
    ..We also show that activation of the cAMP response element binding protein (CREB), which occurs in cells stimulated by FGF-2, is limited when Akt signaling is inhibited, demonstrating a link ..
  14. ncbi D-serine regulates CREB phosphorylation induced by NMDA receptor activation in Müller glia from the retina
    Monica Lamas
    Departamento de Farmacobiologia, CINVESTAV Sede Sur, Calzada de los Tenorios 235, Mexico, D F, Mexico
    Neurosci Lett 427:55-60. 2007
    ..modulates gene expression in Müller glial cells from the retina through the induction of transcription factor CREB phosphorylation and the expression of the immediate-early gene c-fos...
  15. pmc Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein
    Derek M Erion
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell Metab 10:499-506. 2009
    ..Since cAMP response element-binding protein (CREB) is a key regulator of gluconeogenic gene expression, we hypothesized that decreasing hepatic CREB expression would ..
  16. ncbi Brain-derived neurotrophic factor-elicited or sciatic ligation-associated phosphorylation of cyclic AMP response element binding protein in the rat spinal dorsal horn is reduced by block of tyrosine kinase receptors
    Gordana Miletic
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706 1102, USA
    Neurosci Lett 361:269-71. 2004
    Brain-derived neurotrophic factor (BDNF) and cyclic AMP response element binding protein (CREB) may critically contribute to injury-associated plasticity and thus to the development of persistent pain...
  17. pmc Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues
    Xinmin Zhang
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:4459-64. 2005
    ..cellular gene expression by means of the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB) at Ser-133...
  18. ncbi Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections
    Marie K Hoeger-Bement
    Graduate Program in Physical Therapy and Rehabilitation Science, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 23:5437-45. 2003
    ..nociceptive spinal neurons, and phosphorylates the transcription factor cAMP-responsive element binding protein (CREB), which initiates gene transcription...
  19. ncbi Intrathecal injection of cAMP response element binding protein (CREB) antisense oligonucleotide attenuates tactile allodynia caused by partial sciatic nerve ligation
    Weiya Ma
    Department of Anesthesiology, and Center for the Study of Pharmacological Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res 988:97-104. 2003
    The transcription factor cAMP responsive element binding protein (CREB) is important in regulating immediate-early genes and some late-effector genes involved in neuroplasticity in response to peripheral injury and stressful insults...
  20. ncbi A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence
    G A Gonzalez
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, California 92037
    Nature 337:749-52. 1989
    ..We have previously characterized the cAMP response element binding protein (CREB) in PC12 cells and brain tissue as a nuclear factor, of relative molecular mass 43,000, whose transcriptional ..
  21. ncbi Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity
    P Sun
    Department of Cell Biology and Anatomy, Oregon Health Sciences University, Portland 97201
    Genes Dev 8:2527-39. 1994
    The cAMP response element-binding protein (CREB) has been shown to mediate transcriptional activation of genes in response to both cAMP and calcium influx signal transduction pathways...
  22. ncbi Lipopolysaccharide regulates constitutive and inducible transcription factor activities differentially in vivo in the rat
    X Ye
    Division of Pulmonary and Critical Care Medicine, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Biochem Biophys Res Commun 288:927-32. 2001
    ..factor), AP-2 (activating protein-2), AP-1 (activating protein-1), NF-kappaB (nuclear factor kappa B), and CREB (cAMP response element binding protein)...
  23. ncbi Disruption of CREB function in brain leads to neurodegeneration
    Theo Mantamadiotis
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Genet 31:47-54. 2002
    ..To define its roles in the mouse central nervous system, we disrupted Creb1 in brain of developing and adult mice using the Cre/loxP system...
  24. ncbi Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells
    Tomotake Tokunou
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, 812 8582 Fukuoka, Japan
    Circulation 108:1246-52. 2003
    ..Cyclic AMP response element-binding protein (CREB) is a critical transcription factor for the survival of neuronal cells and T lymphocytes...
  25. ncbi CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma
    Stephan Herzig
    Peptide Biology Laboratories Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nature 426:190-3. 2003
    ..In response to pancreatic glucagon and adrenal cortisol, the cAMP-responsive transcription factor CREB activates gluconeogenic and fatty acid oxidation programmes by stimulating expression of the nuclear hormone ..
  26. ncbi Expression of transcription factors c-Fos, c-Jun, CREB-1 and ATF-2, and caspase-3 in relation with abnormal tau deposits in Pick's disease
    María Nieto-Bodelón
    Unitat de Neuropatologia Experimental, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
    Acta Neuropathol 111:341-50. 2006
    ..factors and members of the caspase family in cell death and cell survival, immunohistochemistry to c-Fos, c-Jun, CREB-1, ATF-2; c-Fos(P), c-Jun(P) and CREB-1(P); and procaspase-8, procaspase-3 and active (cleaved) caspase-3 ..
  27. ncbi Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors
    Ming Hu Han
    Department of Psychiatry, Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 26:4624-9. 2006
    The transcription factor cAMP response element-binding protein (CREB) is implicated in mediating the actions of chronic morphine in the locus ceruleus (LC), but direct evidence to support such a role is limited...
  28. pmc Na,K-ATPase signal transduction triggers CREB activation and dendritic growth
    Luc Desfrere
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:2212-7. 2009
    ..triggers dendritic growth as well as a transcriptional program dependent on cAMP response element binding protein (CREB) and cAMP response element (CRE)-mediated gene expression, primarily regulated via Ca(2+)/calmodulin-dependent ..
  29. pmc Deficits in ERK and CREB activation in the hippocampus after traumatic brain injury
    Coleen M Atkins
    The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, United States
    Neurosci Lett 459:52-6. 2009
    ..activated ERK and one of its downstream effectors, the transcription factor cAMP response element-binding protein (CREB). We found that activation of ERK (p<0.05) and CREB (p<0...
  30. doi Cyclic AMP response element-binding protein is implicated in IL-6 production from arthritic synovial cells
    Akihiro Ishizu
    Faculty of Health Sciences, Hokkaido University, Kita 12, Nishi 5, Kita ku, Sapporo, 060 0812, Japan
    Mod Rheumatol 20:134-8. 2010
    ..Cyclic adenosine monophosphate (AMP) response element-binding protein (CREB), a leucine zipper transcription factor, is expressed at a high level in synovial cells of patients with RA...
  31. pmc Involvement of transducer of regulated cAMP response element-binding protein activity on corticotropin releasing hormone transcription
    Ying Liu
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    Endocrinology 151:1109-18. 2010
    We have recently shown that phospho-cAMP response element-binding protein (CREB) is essential but not sufficient for activation of CRH transcription, suggesting the requirement of a coactivator...
  32. ncbi Involvement of spinal PKA/CREB signaling pathway in the development of bone cancer pain
    Li Hua Hang
    Department of Anesthesiology, the Affiliated People s Hospital of Jiangsu University, Zhenjiang Jiangsu 212002, PR China
    Pharmacol Rep 65:710-6. 2013
    It has been shown that spinal PKA/CREB signaling pathway is involved in neuropathic and inflammatory pain, but its effects on bone cancer pain have not previously been investigated...
  33. doi Spinal synaptic scaffolding protein Homer 1b/c regulates CREB phosphorylation and c-fos activation induced by inflammatory pain in rats
    Yong xing Yao
    Department of Anesthesia, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Neurosci Lett 559:88-93. 2014
    ..only markedly reduced the expression of Homer 1b/c protein, but also attenuated CFA-induced inflammation, spinal CREB phosphorylation, and Fos expression...
  34. doi NKCC1 mediates traumatic brain injury-induced hippocampal neurogenesis through CREB phosphorylation and HIF-1α expression
    Kwok Tung Lu
    Department of Life Science, National Taiwan Normal University, Taipei, Taiwan
    Pflugers Arch 467:1651-61. 2015
    ..The TBI-associated alternations in the expression of NKCC1, HIF-1α, VEGF, MAPK cascade, and CREB phosphorylation were analyzed by Western blot...
  35. doi The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats
    Z Liu
    Department of Physiology, Shandong University, School of Medicine, Wenhuaxilu Road, Jinan, Shandong Province 250012, PR China
    Neuroscience 322:358-69. 2016
    ..Moreover, levels of PKA and CREB phosphorylation and the expression of brain-derived neurotrophic factor (BDNF) were decreased in the amygdala of ..
  36. ncbi [Changes in the phosphorylation of cAMP response element binding protein in the rat nucleus accumbens after acute and chronic ethanol administration]
    Jing Li
    Department of Pathology and Pathophysiology, Nanjing Medical University, Nanjing, PR China
    Sheng Li Xue Bao 55:147-52. 2003
    ..the molecular basis of ethanol dependence, changes in the phosphorylation of cAMP response element binding protein (CREB) in the nucleus accumbens of rats after acute and chronic ethanol administration were detected using ..
  37. ncbi Expression of transcription factors CREB and c-Fos in the brains of terminal Creutzfeldt-Jakob disease cases
    A Rodriguez
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neurosci Lett 421:10-5. 2007
    Expression levels and localization of transcription factors cAMP response element binding protein (CREB(1) and CREB(2)) and c-Fos, as well as levels of up-stream mitogen-activated protein kinases/extracellular signal-regulated kinases (..
  38. ncbi Time window for voluntary exercise-induced increases in hippocampal neuroplasticity molecules after traumatic brain injury is severity dependent
    Grace S Griesbach
    Division of Neurosurgery, University of California Los Angeles UCLA, Los Angeles, California, USA
    J Neurotrauma 24:1161-71. 2007
    ..Rats were sacrificed at PID 7, 21, or 37. BDNF, synapsin I, and cyclic AMP response element binding protein (CREB) were analyzed within the ipsilateral hippocampus...
  39. pmc Naloxone's pentapeptide binding site on filamin A blocks Mu opioid receptor-Gs coupling and CREB activation of acute morphine
    Hoau Yan Wang
    Department of Physiology and Pharmacology, City University of New York Medical School, New York, New York, United States of America
    PLoS ONE 4:e4282. 2009
    ..ultra-low-dose NTX also attenuates the addictive properties of opioids, we assessed striatal cAMP production and CREB phosphorylation at S(133)...
  40. pmc AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner
    Ji Min Lee
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Biol Chem 285:32182-91. 2010
    ..that SHP inhibited protein kinase A-mediated transcriptional activity of cAMP-response element-binding protein (CREB), a major regulator of glucose metabolism, to modulate hepatic gluconeogenic gene expression...
  41. doi PPARγ-mediated advanced glycation end products regulate neural stem cell proliferation but not neural differentiation through the BDNF-CREB pathway
    Shao Hua Wang
    The Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, No 87 DingJiaQiao Road, Nanjing 210009, PR China
    Toxicol Lett 206:339-46. 2011
    ..To investigate the roles of PPARγ in advanced glycation end product (AGE)-mediated characteristics of neural stem cells (NSCs) and the molecular mechanisms of action...
  42. doi Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat
    Lan Zhang
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China
    Brain Res Bull 96:45-53. 2013
    There is cumulative evidence that the serine-threonine kinase Akt and its downstream nuclear transcription factor CREB are involved in neuronal survival and protection...
  43. pmc CREB modulates calcium signaling in cAMP-induced bone marrow stromal cells (BMSCs)
    Linxia Zhang
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, United States
    Cell Calcium 56:257-68. 2014
    ..Concurrently, cAMP transiently activated the transcription factor cAMP response element binding protein (CREB) in BMSCs...
  44. pmc Acupuncture stimulation improves scopolamine-induced cognitive impairment via activation of cholinergic system and regulation of BDNF and CREB expressions in rats
    Bombi Lee
    Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae ro, Dongdaemun Gu, Seoul 130 701, Republic of Korea
    BMC Complement Altern Med 14:338. 2014
    ..We also investigated the effects of acupuncture stimulation at GV20 on the cholinergic system as well as the expression of brain-derived neurotrophic factor (BDNF) and cAMP-response element-binding protein (CREB) in the hippocampus.
  45. pmc Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells
    Chrystelle V Garat
    Cardiovascular Pulmonary Research, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Campus Box B 133, Denver, CO 80262, USA
    Mol Cell Biol 26:4934-48. 2006
    Cyclic AMP response element binding protein (CREB) content is diminished in smooth muscle cells (SMCs) in remodeled pulmonary arteries from animals with pulmonary hypertension and in the SMC layers of atherogenic systemic arteries and ..
  46. ncbi Several transcription factors regulate COX-2 gene expression in pancreatic beta-cells
    Xiongfei Zhang
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing, PR China
    Mol Biol Rep 34:199-206. 2007
    ..Among these factors, cyclic AMP response-element binding protein (CREB), Ets family members Ets-1 and Elk-1 can positively regulate COX-2 promoter activity...
  47. pmc Effects of A-CREB, a dominant negative inhibitor of CREB, on the expression of c-fos and other immediate early genes in the rat SON during hyperosmotic stimulation in vivo
    Daniel Lubelski
    Laboratory of Neurochemistry, Molecular Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res 1429:18-28. 2012
    ..These increases have usually been attributed to action of the cyclic-AMP Response Element Binding Protein (CREB)...
  48. doi Depletion of intracellular zinc induced apoptosis in cultured hippocampal neurons through Raf/MEK/ERK pathways
    Wei Pang
    Department of Nutrition, Institute of Hygiene and Environmental Medicine, Academy of Military Medical Science, Tianjin, China
    Nutr Neurosci 15:18-24. 2012
    ..It is possible that zinc depletion-induced apoptosis in cultured hippocampal neurons may be relevant to the changes of Raf/MEK/ERK signaling pathway...
  49. ncbi cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts
    Xiaoqiu Liu
    Department of Pharmacology and the Vascular Biology Center of Excellence, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Mol Pharmacol 70:1992-2003. 2006
    ..with 10 microM forskolin or isoproterenol increased cAMP production and cAMP response element binding protein (CREB) phosphorylation in cardiac fibroblasts and inhibited serum- or TGF-beta-stimulated collagen synthesis by 37% or ..
  50. ncbi [Effects of intrathecal injection of U0126 on the expression of phospho-CREB in spinal cord of morphine-induced withdrawal rats]
    Hai Lin Liu
    Department of Anesthesiology, 1st Hospital of Huai an, Affiliated Hospital of Nanjing Medical University, Huai An 223300, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 23:5-8. 2007
    To explore effects of intrathecal injection of U0126 on morphine withdrawal response and the spinal Phospho-CREB expression in morphine-induced withdrawal rats.
  51. pmc Corticotropin-releasing factor and urocortin I activate CREB through functionally selective Gβγ signaling in hippocampal pyramidal neurons
    Christopher M Stern
    Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA
    Eur J Neurosci 34:671-81. 2011
    ..molecular mechanisms by which CRF and UCN induce phosphorylation of the activity-dependent transcription factor CREB, a molecule critical for numerous forms of neuronal plasticity...
  52. doi Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1)
    Ivonne Bazwinsky-Wutschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle, Germany
    J Pineal Res 53:344-57. 2012
    ..In conclusion, the present study provides evidence that the phosphorylation level of CREB is modulated in pancreatic β-cells by melatonin...
  53. doi Sleep deprivation alters phosphorylated CREB levels in the amygdala: relationship with performance in a fear conditioning task
    Nadine Pinho
    Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Behav Brain Res 236:221-4. 2013
    ..Moreover, 24h of sleep recovery prior to training prevented changes in both pCREB expression and performance...
  54. ncbi Novel testis germ cell-specific transcript of the CREB gene contains an alternatively spliced exon with multiple in-frame stop codons
    G Waeber
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston 02114
    Endocrinology 131:2010-5. 1992
    The gene encoding the cAMP-responsive transcription factor CREB consists of multiple small exons some of which undergo alternative RNA splicing...
  55. pmc Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells
    M L Short
    Department of CMS Biology, Northwestern University Medical School and Cancer Center, Chicago, IL 60611
    Nucleic Acids Res 19:4290. 1991
  56. ncbi Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains
    I Radhakrishnan
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA
    J Mol Biol 287:859-65. 1999
    A number of signal-dependent and development-specific transcription factors recruit CREB binding protein (CBP) for their transactivation function. The KIX domain of CBP is a common docking site for many of these transcription factors...
  57. pmc Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors
    Lan Ko
    Department of Gene Regulation, Bone and Inflammation Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Mol Cell Biol 22:357-69. 2002
    ..These data suggest that GT198 is a tissue-specific, kinase-regulated nuclear receptor coactivator that interacts with the DNA-binding domains of nuclear receptors...
  58. ncbi The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB)
    Jean Francois Louet
    Institut Cochin, Departement d Endocrinologie, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    J Biol Chem 277:37991-8000. 2002
    ..of this gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB)...
  59. ncbi Essential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascade
    Hsiao Chun Cheng
    Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan, Republic of China
    J Biol Chem 277:33930-42. 2002
    ..PKA, thus, appears to mediate the A(2A)-rescue effect. Results from cAMP-response element-binding protein (CREB) phosphorylation at serine 133, trans-reporting assays, and overexpression of two dominant-negative CREB mutants ..
  60. ncbi Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I
    Akiko Tabuchi
    Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama, Japan
    J Biol Chem 277:35920-31. 2002
    ..CRE-binding protein (CREB) family transcription factors and USF1/USF2 bind to this overlapping site, depending upon their preferred sequences ..
  61. ncbi Localization and functional investigation of the transcription factor CREB in taste receptor cells
    Yu Cao
    Department of Oral Biology, College of Dentistry, Ohio State University, 305 West 12th Avenue, Columbus, OH 43218, USA
    Neuroreport 13:1321-5. 2002
    ..We investigated the presence of cAMP response element-binding protein (CREB), a stimulus-induced transcription factor, in taste receptor cells...
  62. ncbi Involvement of cyclic adenosine 5'-monophosphate response element-binding protein, steroidogenic factor 1, and Dax-1 in the regulation of gonadotropin-inducible ovarian transcription factor 1 gene expression by follicle-stimulating hormone in ovarian gran
    Takashi Yazawa
    Department of Biochemistry, Fukui Medical University, Fukui 910 1193, Japan
    Endocrinology 144:1920-30. 2003
    ..These results suggest that the synergistic action of CRE binding protein and SF-1 and the rapid down-regulation of Dax-1 are responsible for the acute induction of GIOT1 gene by gonadotropin...
  63. ncbi Transcriptional regulation of the promoter of the rat frizzled related protein gene by CREB
    Judy Wai Ping Yam
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Oncogene 22:3901-10. 2003
    ..Further EMSA suggested CREB as the trans-acting factor in the DNA-protein complex, which was out competed by CREB consensus oligonucleotides ..
  64. ncbi Differential pattern of cAMP response element-binding protein activation in the rat brain after conditioned aversion as a function of the associative process engaged: taste versus context association
    Aline Desmedt
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 23:6102-10. 2003
    Ample data indicate that cAMP-response element-binding protein (CREB) is essential for the formation of long-term memory in various species and learning systems...
  65. ncbi Long-term effects of early-life malnutrition and status epilepticus: assessment by spatial navigation and CREB(Serine-133) phosphorylation
    Li Tung Huang
    Department of Pediatrics, Chang Gung Memorial Hospital, No 123, Ta Pei Road, Niao Sung, Kaohsiung 833, Taiwan
    Brain Res Dev Brain Res 145:213-8. 2003
    ..Collectively, the present results suggest that early-life malnutrition led to a reduced phosphorylation of CREB(Ser133) in hippocampal CA1 in the absence of the long-term spatial learning deficit...
  66. ncbi Role of basic helix-loop-helix (bHLH) and CREB transcription factors in the regulation of Sertoli cell androgen-binding protein expression
    Melissa A Saxlund
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Mol Reprod Dev 68:269-78. 2004
    ..by the binding and interactions of basic helix-loop-helix (bHLH) and cAMP response element binding protein (CREB) to an E-box and cyclic AMP response element (CRE), respectively...
  67. ncbi Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein via calcium and protein kinase Calpha
    Cesar Cardenas
    Centro de Estudios Moleculares de la Célula, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 7, Chile
    J Biol Chem 279:39122-31. 2004
    ..signals that regulate the activity of transcription factors such as the cAMP-response element-binding protein (CREB), jun, and fos...
  68. pmc Testosterone activates mitogen-activated protein kinase and the cAMP response element binding protein transcription factor in Sertoli cells
    Charity Fix
    Department of Cell Biology and Physiology, University of Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 101:10919-24. 2004
    ..These newly identified mechanisms of androgen action in Sertoli cells suggest new targets for developing male contraceptive agents...
  69. ncbi CREB phosphorylation and c-Fos expression in the hippocampus of rats during acquisition and recall of a socially transmitted food preference
    Renee A Countryman
    Department of Psychology, Tulane University, New Orleans, Louisiana 70118, USA
    Hippocampus 15:56-67. 2005
    ..The current results indicate that the activity of transcription factors in the hippocampus is related to both acquisition and retention of a socially transmitted food preference...
  70. ncbi Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm
    Yoshiko Katoh
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine H 1, Osaka University, Japan
    Eur J Biochem 271:4307-19. 2004
    ..To our surprise, the cytoplasmic mutants strongly repressed the CRE-binding protein (CREB) activity, the extent of repression being similar to that of SIK1(S577A), a mutant localized exclusively in the ..
  71. ncbi Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133
    Boyoung Lee
    Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 25:1137-48. 2005
    ..and nontoxic levels of NMDA receptor stimulation to activation of the cAMP response element-binding protein (CREB)/cAMP response element (CRE) pathway in cultured cortical neurons...
  72. ncbi LH/hCG-stimulated androgen production and selective HDL-cholesterol transport are inhibited by a dominant-negative CREB construct in primary cultures of rat theca-interstitial cells
    Roberto Towns
    Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Endocrine 27:269-77. 2005
    ..Ad)-mediated introduction of a dominant-negative analog of cyclic AMP response element binding protein (A-CREB) inhibits the stimulatory effect of LH/hCG on the selective uptake of high-density lipoprotein (HDL)-cholesterol ..
  73. ncbi NMDA receptors regulate developmental gap junction uncoupling via CREB signaling
    Harsha Arumugam
    Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, USA
    Nat Neurosci 8:1720-6. 2005
    ..of NMDA glutamate receptors, action potentials and the calcium-cyclic AMP response element binding protein (CREB), and are accelerated by CREB overexpression...
  74. ncbi A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons
    Antonella Riccio
    Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21201, USA
    Mol Cell 21:283-94. 2006
    Prevailing views of neurotrophin action hold that the transcription factor CREB is constitutively bound to target genes with transcriptional activation occurring via CREB phosphorylation...
  75. ncbi Involvement of ERK and CREB signaling pathways in the protective effect of PACAP in monosodium glutamate-induced retinal lesion
    Boglarka Racz
    Department of Surgical Research, University of Pecs, 7624 Pecs, Szigeti u 12 Hungary
    Ann N Y Acad Sci 1070:507-11. 2006
    ..signal-regulated kinase (ERK1/2) and cyclic adenosine 3',5'-phosphate (cAMP)-responsive element binding protein (CREB) signaling pathways by Western blot analysis in retinal degeneration induced by MSG...
  76. ncbi Myotube depolarization generates reactive oxygen species through NAD(P)H oxidase; ROS-elicited Ca2+ stimulates ERK, CREB, early genes
    Alejandra Espinosa
    Escuela de Tecnología Médica, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Cell Physiol 209:379-88. 2006
    ..Minutes after Ca2+ signal initiation, an increase in ERK1/2 and CREB phosphorylation and of mRNA for the early genes c-fos and c-jun was detected...
  77. ncbi Estrogen rapidly modulates mustard oil-induced visceral hypersensitivity in conscious female rats: A role of CREB phosphorylation in spinal dorsal horn neurons
    Ching Liang Lu
    Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Rd, Taipei, Taiwan 11217
    Am J Physiol Gastrointest Liver Physiol 292:G438-46. 2007
    ..cAMP-responsive element-binding protein (CREB) and phosphorylated CREB (pCREB) were detected in the superficial dorsal horn of L6 and S1 in MO or mineral oil-..
  78. pmc Phosphorylation of the cyclic AMP response element binding protein mediates transforming growth factor beta-induced downregulation of cyclin A in vascular smooth muscle cells
    Kentaro Kamiya
    Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY 1002, USA
    Mol Cell Biol 27:3489-98. 2007
    ..gene through a cyclic AMP (cAMP) response element, which complexes with the cAMP response element binding protein (CREB)...
  79. ncbi Involvement of cAMP response element-binding protein in the regulation of cell proliferation and the prolactin promoter of lactotrophs in primary culture
    Maho Ishida
    Dept of Physiology, Interdisciplinary Graduate School of Medicine and Engineering, Univ of Yamanashi, 409 3898, Japan
    Am J Physiol Endocrinol Metab 293:E1529-37. 2007
    ..The PKA-downstream transcription factor cAMP response element (CRE)-binding protein (CREB) is an integrating molecule that is also activated by many other protein kinase pathways...
  80. doi TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway
    Yilin Tai
    Laboratory of Neural Signal Transduction, Institute of Neuroscience, Shanghai Institutes of Biological Sciences, State Key Laboratory of Neuroscience, The Graduate School, Chinese Academy of Science, Shanghai, People s Republic of China
    J Cell Sci 121:2301-7. 2008
    ..phosphorylation of Ca(2+)/calmodulin-dependent kinase IV (CaMKIV) and cAMP-response-element binding protein (CREB) and promoted dendritic growth in hippocampal cultures...
  81. pmc CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling
    Damian G Wheeler
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 183:849-63. 2008
    ....
  82. pmc TOX3 regulates calcium-dependent transcription in neurons
    Shauna H Yuan
    Department of Neuroscience and Neurobiology Section, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093 0366
    Proc Natl Acad Sci U S A 106:2909-14. 2009
    ..We find that TOX3 interacts with both cAMP response element (CRE)-binding protein (CREB) and CREB-binding protein (CBP), and knockdown of the endogenous TOX3 by RNAi leads to significant reduction of ..
  83. pmc Pretreatment with a single estradiol-17beta bolus activates cyclic-AMP response element binding protein and protects CA1 neurons against global cerebral ischemia
    A P Raval
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Neuroscience 160:307-18. 2009
    ..neurons against global cerebral ischemia via activation of the cyclic-AMP response element binding protein (CREB)-mediated signaling cascade...
  84. pmc Viral vector induction of CREB expression in the periaqueductal gray induces a predator stress-like pattern of changes in pCREB expression, neuroplasticity, and anxiety in rodents
    Robert Adamec
    Department of Psychology, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3X9
    Neural Plast 2009:904568. 2009
    Predator stress is lastingly anxiogenic. Phosphorylation of CREB to pCREB (phosphorylated cyclic AMP response element binding protein) is increased after predator stress in fear circuitry, including in the right lateral column of the PAG (..
  85. doi Morphine withdrawal regulates phosphorylation of cAMP response element binding protein (CREB) through PKC in the nucleus tractus solitarius-A2 catecholaminergic neurons
    Fátima Martín
    Department of Pharmacology, University School of Medicine, Murcia 30100, Spain
    J Neurochem 110:1422-32. 2009
    The transcription factor cAMP response element binding protein (CREB) has been implicated in the actions of drugs of abuse in several brain areas...
  86. doi 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade
    Md Al Rahim
    Laboratory of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai 980 8578, Japan
    Biochemistry 48:7713-21. 2009
    ..a major metabolite of nobiletin identified in the urine of rats and mice, stimulates the phosphorylation of ERK and CREB and enhances CRE-mediated transcription by activating a PKA/MEK/ERK pathway, like nobiletin, in cultured ..
  87. doi Memory impairment in early sensorimotor deprived rats is associated with suppressed hippocampal neurogenesis and altered CREB signaling
    Fei Li
    Child Primary Care Department of Shanghai Children s Medical Center, Shanghai Jiao Tung University School of Medicine, Shanghai, China
    Behav Brain Res 207:458-65. 2010
    ..In this study we tested the hypothesis that altered cAMP response element binding (CREB) protein induction and activity-regulated cytoskeletal-associated gene (Arc) expression may underlie the ..
  88. pmc Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats
    Meng Yen Li
    Department of Cell Biology and Anatomy, National Cheng Kung University Medical College, Tainan, Taiwan
    PLoS ONE 4:e7820. 2009
    ..Here, we investigated the functional role of WOX1 and transcription factors in the delayed loss of axotomized neurons in dorsal root ganglia (DRG) in rats...
  89. doi The cAMP response element-binding protein in the bed nucleus of the stria terminalis modulates the formalin-induced pain behavior in the female rat
    Hiroko Hagiwara
    Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan
    Eur J Neurosci 30:2379-86. 2009
    ..To determine the role of CREB in the BSTLD, adenovirus-mediated expression of a dominant-negative form of CREB (mCREB) was carried out...
  90. pmc CREB downregulation in vascular disease: a common response to cardiovascular risk
    Irene E Schauer
    Department of Medicine, University of Colorado at Denver Anschutz Medical Campus, Aurora, CO, USA
    Arterioscler Thromb Vasc Biol 30:733-41. 2010
    ..the impact of low-density lipoprotein (LDL), an established mediator of atherosclerosis, on the transcription factor cAMP-response element-binding protein (CREB), which is a regulator of vascular smooth muscle cell (VSMC) quiescence.
  91. ncbi Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia
    Silvia Carloni
    Department of Drug and Health Science, University of Urbino Carlo Bo, Urbino, Italy
    Autophagy 6:366-77. 2010
    ..The phosphorylation of Akt and cAMP response element binding protein (CREB) was increased in neuronal cells, and both p-Akt and p-CREB colocalized with Beclin 1...
  92. pmc Striatal microRNA controls cocaine intake through CREB signalling
    Jonathan A Hollander
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA
    Nature 466:197-202. 2010
    ..of cocaine by markedly amplifying the stimulatory effects of the drug on cAMP response element binding protein (CREB) signalling...
  93. doi [Change of p-CREB after surgical incisional pain in rat spinal cord]
    Yulong Cui
    Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:833-9. 2010
    To explore the role of phosphorylation of cAMP response element binding protein (CREB) in the incision-induced pain hypersensitivity.
  94. pmc T-type Ca²+ signalling regulates aldosterone-induced CREB activation and cell death through PP2A activation in neonatal cardiomyocytes
    Laurent Ferron
    Departement de Recherche Medicale, Remodelage tissulaire et fonctionnel signalisation et physiopathologie CNRS UMR8162, Le Plessis Robinson, France
    Cardiovasc Res 90:105-12. 2011
    ....
  95. doi Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: protection by caffeine
    Ibrahim A Alhaider
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA
    Mol Cell Neurosci 46:742-51. 2011
    ..frequency stimulation-induced increases in the levels of phosphorylated-cAMP response element binding protein (P-CREB) and brain-derived neurotrophic factor (BDNF) seen during the expression of late phase long-term potentiation (L-..
  96. doi NR2B-containing NMDA receptors promote neural progenitor cell proliferation through CaMKIV/CREB pathway
    Mei Li
    Department of Anatomy and Neurobiology, Xuzhou Medical College, China
    Biochem Biophys Res Commun 411:667-72. 2011
    ..levels of calcium/calmodulin-dependent protein kinase IV (CaMKIV) and cAMP response element binding protein (CREB) were increased by NMDA treatment, whereas Ro 25-6981 decreased them...
  97. ncbi Involvement of cAMP-response element binding protein in corticotropin-releasing factor (CRF)-induced down-regulation of CRF receptor 1 gene expression in rat anterior pituitary cells
    Y Kasagi
    Department of Bioregulation, Nippon Medical School, Kawasaki, Japan
    J Neuroendocrinol 14:587-92. 2002
    ..pretreatment with 10 microM of antisense oligodeoxynucleotide for cyclic AMP-response element binding protein (CREB), the CRF-induced inhibition of CRF-R1 mRNA was partially decreased to 79+/-4% of the control level 2 h after ..
  98. pmc Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling
    Ottavio V Vitolo
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain and Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:13217-21. 2002
    ..Consistent with this, CREB phosphorylation in response to glutamate is decreased, and the decrease is reversed by rolipram, a ..
  99. pmc Calcium-dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein (CREB)
    Rosemary A Schuh
    Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurochem 92:388-94. 2005
    Calcium-mediated signaling regulates nuclear gene transcription by calcium/cAMP response element binding protein (CREB) via calcium-dependent kinases and phosphatases...
  100. ncbi cAMP responsive element-binding protein phosphorylation is necessary for perirhinal long-term potentiation and recognition memory
    E Clea Warburton
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1 TD, United Kingdom
    J Neurosci 25:6296-303. 2005
    We established the importance of phosphorylation of cAMP responsive element-binding protein (CREB) to both the familiarity discrimination component of long-term recognition memory and plasticity within the perirhinal cortex of the ..
  101. ncbi CAAT/enhancer-binding protein delta and cAMP-response element-binding protein mediate inducible expression of the nerve growth factor gene in the central nervous system
    Christine Seitz McCauslin
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute, National Institutes of Health, Frederick, MD 21702 1201, USA
    J Biol Chem 281:17681-8. 2006
    ..we have further defined the function of C/EBPdelta and identified a role for cAMP response element-binding protein (CREB) in NGF transcription...

Research Grants7

  1. Amygdala, CREB, and Neuropathic Pain Facilitation
    JENNIFER PETTA; Fiscal Year: 2007
    ..SNI) model of peripheral mononeuropathy, the experiments in this proposal will test hypotheses that NMDA- and CREB-dependent mechanisms in the CeA contribute to chronic neuropathic pain...
  2. GENETICS OF RECURRENT EARLY-ONSET DEPRESSION (GENRED)
    GEORGE ZUBENKO; Fiscal Year: 2002
    ..A timetable is proposed for rapid sharing of all biological materials, blinded clinical data, genotypes and linkage analyses with the scientific community through the NIMH-sponsored Center for Genetic Studies. ..
  3. BIOLOGICAL MARKER FOR PRIMARY DEMENTIA IN THE ELDERLY
    GEORGE ZUBENKO; Fiscal Year: 2003
    ....
  4. Voluntary Exercise Therapy after Traumatic Brain Injury
    GRACE GRIESBACH; Fiscal Year: 2006
    ..In order to address these specific aims, I will utilize the lateral fluid-percussion injury model in rats and voluntary running wheel exposure. Protein, gene, histological and behavioral studies will be conducted. ..
  5. Regulation of the CART gene by promoter cis-elements
    George Rogge; Fiscal Year: 2008
    ..Finally, we will evaluate the potential contribution of the TF CREB to CART gene transcription by performing chromatin immunoprecipitaion on cross-linked rat NAc tissue...
  6. MORPHOLOGIC/NEUROCHEMICAL CORRELATES OF DEPRESSION IN AD
    GEORGE ZUBENKO; Fiscal Year: 2009
    ..abstract_text> ..
  7. Mechanisms Underlying the Cognitive Function of Sleep
    Subimal Datta; Fiscal Year: 2009
    ..during REM sleep stimulates the post-synaptic cAMP/protein kinase A/cAMP response element binding protein (cAMP/PKA/CREB) pathway in the dorsal hippocampus as part of REM sleep-dependent memory processing...