Corin

Summary

Gene Symbol: Corin
Description: corin, serine peptidase
Alias: atrial natriuretic peptide-converting enzyme, pro-ANP-converting enzyme
Species: rat

Top Publications

  1. pmc Corin is down-regulated and exerts cardioprotective action via activating pro-atrial natriuretic peptide pathway in diabetic cardiomyopathy
    Aiming Pang
    Hematopoietic Stem Cell Transplantation Center, Institute of Hematology and Blood Diseases Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin, 300020, China
    Cardiovasc Diabetol 14:134. 2015
  2. ncbi Rat corin gene: molecular cloning and reduced expression in experimental heart failure
    Thomas H Langenickel
    Max Delbrueck Center for Molecular Medicine, Berlin 13092, Germany
    Am J Physiol Heart Circ Physiol 287:H1516-21. 2004
  3. ncbi Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium
    Katherine L Tran
    Department of Cardiovascular Research, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA
    Am J Physiol Heart Circ Physiol 287:H1625-31. 2004
  4. ncbi Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension
    Daniel L Dries
    Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, University of Texas at Southwestern Medical Center, Dallas, USA
    Circulation 112:2403-10. 2005
  5. ncbi Scar myofibroblasts of the infarcted rat heart express natriuretic peptides
    Angelino Calderone
    Department of Physiology, University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada
    J Cell Physiol 207:165-73. 2006
  6. ncbi The serine protease corin in cardiovascular biology and disease
    Qingyu Wu
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Front Biosci 12:4179-90. 2007
  7. ncbi Role of glycosylation in corin zymogen activation
    Xudong Liao
    Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 282:27728-35. 2007
  8. pmc Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases
    Danny Polzin
    Institute of Anatomy, Charite Universitatsmedizin, Berlin, Germany
    Kidney Int 78:650-9. 2010

Research Grants

Scientific Experts

  • Thomas H Langenickel
  • Qingyu Wu
  • Daniel Dries
  • Angelino Calderone
  • Aiming Pang
  • Danny Polzin
  • Wei Wang
  • Xudong Liao
  • Katherine L Tran
  • Yanna Shen
  • Pengfei Zhou
  • Guangfeng Long
  • Yujie Cui
  • Yunde Liu
  • Li Men
  • Yahui Hu
  • Xin Tian
  • Henriette J Kaminski
  • Franziska Theilig
  • Alain Vandewalle
  • Michael Russwurm
  • Stephanie Kramer
  • Harm Peters
  • Christian Kastner
  • Stepan Gambaryan
  • Sebastian Bachmann
  • Shenghan Chen
  • Qingping Feng
  • Xiangru Lu
  • Ming Lei

Detail Information

Publications8

  1. pmc Corin is down-regulated and exerts cardioprotective action via activating pro-atrial natriuretic peptide pathway in diabetic cardiomyopathy
    Aiming Pang
    Hematopoietic Stem Cell Transplantation Center, Institute of Hematology and Blood Diseases Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin, 300020, China
    Cardiovasc Diabetol 14:134. 2015
    ..b>Corin, a cardiac serine protease, is responsible for converting pro-atrial natriuretic peptide (pro-ANP) to biologically ..
  2. ncbi Rat corin gene: molecular cloning and reduced expression in experimental heart failure
    Thomas H Langenickel
    Max Delbrueck Center for Molecular Medicine, Berlin 13092, Germany
    Am J Physiol Heart Circ Physiol 287:H1516-21. 2004
    ..b>Corin is a serin protease with pro-ANP-converting properties and may be the rate-limiting enzyme in ANP release...
  3. ncbi Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium
    Katherine L Tran
    Department of Cardiovascular Research, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA
    Am J Physiol Heart Circ Physiol 287:H1625-31. 2004
    ..Recently, we have identified a cardiac serine protease, corin, that is the pro-ANP convertase...
  4. ncbi Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension
    Daniel L Dries
    Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, University of Texas at Southwestern Medical Center, Dallas, USA
    Circulation 112:2403-10. 2005
    The natriuretic peptide system contributes to blood pressure regulation. Atrial and brain natriuretic peptides are cleaved into smaller biologically active molecules by corin, a transmembrane serine protease expressed in cardiomyocytes.
  5. ncbi Scar myofibroblasts of the infarcted rat heart express natriuretic peptides
    Angelino Calderone
    Department of Physiology, University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada
    J Cell Physiol 207:165-73. 2006
    ..myofibroblasts, alpha-myosin heavy chain mRNA was undetectable, whereas ANP, BNP, as well as adrenomedullin and corin mRNA expression persisted...
  6. ncbi The serine protease corin in cardiovascular biology and disease
    Qingyu Wu
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Front Biosci 12:4179-90. 2007
    b>Corin is a type II transmembrane serine protease expressed primarily in the heart...
  7. ncbi Role of glycosylation in corin zymogen activation
    Xudong Liao
    Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 282:27728-35. 2007
    The cardiac serine protease corin is the pro-atrial natriuretic peptide convertase. Corin is made as a zymogen, which is activated by proteolytic cleavage...
  8. pmc Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases
    Danny Polzin
    Institute of Anatomy, Charite Universitatsmedizin, Berlin, Germany
    Kidney Int 78:650-9. 2010
    ..Microarray analysis identified a reduction in kidney corin mRNA expression in rat models of puromycin aminonucleoside-induced nephrotic syndrome and acute anti-Thy1 ..

Research Grants1

  1. Genetic Determinants of Hypertension, LVH, and CHF
    Daniel Dries; Fiscal Year: 2006
    ..to the cardiac hormonal signaling pathways (the gene for ANP, BNP, the type A and C cardiac hormone receptors, and corin)...