Col4a1

Summary

Gene Symbol: Col4a1
Description: collagen type IV alpha 1 chain
Alias: collagen alpha-1(IV) chain, alpha 1 type IV collagen, collagen, type IV, alpha 1, procollagen, type IV, alpha 1
Species: rat

Top Publications

  1. doi Effects of angiotensin II intervention on MMP-2, MMP-9, TIMP-1, and collagen expression in rats with pulmonary hypertension
    X M Wang
    Department of Pediatric Cardiology, Chengdu Women s and Children s Central Hospital, Chengdu, China
    Genet Mol Res 14:1707-17. 2015
  2. ncbi Type I collagen gel modulates extracellular matrix synthesis and deposition by tracheal epithelial cells
    E A Davenport
    Laboratory of Pulmonary Pathobiology, Airway Cell Biology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Exp Cell Res 223:155-62. 1996
  3. ncbi Structure of the rat collagen IV promoter
    J P Grande
    Department of Laboratory Medicine and Pathology, Mayo Graduate School of Medicine, Rochester, MN 55905, USA
    Biochim Biophys Acta 1309:85-8. 1996
  4. ncbi Neonatal porencephaly and adult stroke related to mutations in collagen IV A1
    Marjo S van der Knaap
    Department of Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Neurol 59:504-11. 2006
  5. ncbi Role of COL4A1 in small-vessel disease and hemorrhagic stroke
    Douglas B Gould
    Howard Hughes Medical Institute, Bar Harbor, ME, USA
    N Engl J Med 354:1489-96. 2006
  6. ncbi A possible role of thioredoxin interacting protein in the pathogenesis of streptozotocin-induced diabetic nephropathy
    Yasuhiro Hamada
    Division of Nephrology and Dialysis Center, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 53:53-61. 2007
  7. ncbi Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population
    Y Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    J Med Genet 45:216-21. 2008
  8. doi Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice
    A K H Lim
    Department of Nephrology, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Diabetologia 52:1669-79. 2009
  9. pmc Regulation of type IV collagen alpha chains of glomerular epithelial cells in diabetic conditions
    Tae Sun Ha
    Department of Pediatrics, Chungbuk National University, Cheongju, Korea
    J Korean Med Sci 24:837-43. 2009

Scientific Experts

  • Marjo S van der Knaap
  • Tae Sun Ha
  • Yoshiji Yamada
  • X M Wang
  • A K H Lim
  • Yasuhiro Hamada
  • Douglas B Gould
  • Y L Liu
  • T T Chen
  • S Yang
  • Y H Guo
  • J J Li
  • Y F Yang
  • K Shi
  • F Y Ma
  • D J Nikolic-Paterson
  • G H Tesch
  • L A Hurst
  • M C Thomas
  • Masafumi Fukagawa
  • Elisabeth Tournier-Lasserve
  • Peter Heutink
  • F Campbell Phalan
  • Marie Germaine Bousser
  • Simon W M John
  • John P Sundberg
  • Jeffrey H Miner
  • Saskia E van Mil
  • Pascale Massin
  • Katayoun Vahedi
  • E A Davenport
  • J P Grande
  • D L Kluge
  • D C Melder
  • P Nettesheim
  • E D Wieben

Detail Information

Publications9

  1. doi Effects of angiotensin II intervention on MMP-2, MMP-9, TIMP-1, and collagen expression in rats with pulmonary hypertension
    X M Wang
    Department of Pediatric Cardiology, Chengdu Women s and Children s Central Hospital, Chengdu, China
    Genet Mol Res 14:1707-17. 2015
    ..Real-time fluorescent quantitative PCR was used to detect MMP2, MMP9, TIMP1, COL1A1, and COL4A1 mRNA expression. Picro-sirius red staining was performed to detect collagen protein expression...
  2. ncbi Type I collagen gel modulates extracellular matrix synthesis and deposition by tracheal epithelial cells
    E A Davenport
    Laboratory of Pulmonary Pathobiology, Airway Cell Biology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Exp Cell Res 223:155-62. 1996
    ..These date demonstrate that ECM RNA and protein expression by RTE cells in ALI cultures are down-regulated by type I collagen gel whereas differentiation and ECM deposition are accelerated and enhanced on type I collagen gel...
  3. ncbi Structure of the rat collagen IV promoter
    J P Grande
    Department of Laboratory Medicine and Pathology, Mayo Graduate School of Medicine, Rochester, MN 55905, USA
    Biochim Biophys Acta 1309:85-8. 1996
    ..Our results suggest that transcriptional efficiency of the bidirectional promoter is more efficient in the alpha 2 (IV) direction than in the alpha 1 (IV) direction...
  4. ncbi Neonatal porencephaly and adult stroke related to mutations in collagen IV A1
    Marjo S van der Knaap
    Department of Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Neurol 59:504-11. 2006
    ..The objective of this study was to describe leukoencephalopathy, lacunar infarcts, microbleeds and macrobleeds in the context of a collagen IV A1 mutation...
  5. ncbi Role of COL4A1 in small-vessel disease and hemorrhagic stroke
    Douglas B Gould
    Howard Hughes Medical Institute, Bar Harbor, ME, USA
    N Engl J Med 354:1489-96. 2006
    ..In this report, we show that a mutation in the mouse Col4a1 gene, encoding procollagen type IV alpha1, predisposes both newborn and adult mice to intracerebral hemorrhage...
  6. ncbi A possible role of thioredoxin interacting protein in the pathogenesis of streptozotocin-induced diabetic nephropathy
    Yasuhiro Hamada
    Division of Nephrology and Dialysis Center, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 53:53-61. 2007
    ..In addition, the expression of Type IV collagen alpha1 chain (Col4A1), Transforming growth factor-beta (TGF-beta), and Txnip were evaluated by real-time polymerase chain reaction...
  7. ncbi Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population
    Y Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    J Med Genet 45:216-21. 2008
    ..Although several environmental factors influence the development of myocardial infarction (MI), genetic factors have been shown to contribute to individual susceptibility to this condition...
  8. doi Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice
    A K H Lim
    Department of Nephrology, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Diabetologia 52:1669-79. 2009
    ..Therefore, we used c-fms blockade as a strategy to selectively target macrophage-mediated injury during the progression of diabetic nephropathy...
  9. pmc Regulation of type IV collagen alpha chains of glomerular epithelial cells in diabetic conditions
    Tae Sun Ha
    Department of Pediatrics, Chungbuk National University, Cheongju, Korea
    J Korean Med Sci 24:837-43. 2009
    ....