Chrm3

Summary

Gene Symbol: Chrm3
Description: cholinergic receptor, muscarinic 3
Alias: muscarinic acetylcholine receptor M3, cholinergic receptor, muscarinic 3, cardiac
Species: rat

Top Publications

  1. pmc Immunoglobulins from scleroderma patients inhibit the muscarinic receptor activation in internal anal sphincter smooth muscle cells
    Jagmohan Singh
    Department of Medicine, Thomas Jefferson Univ, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1206-13. 2009
  2. doi The impact of simulated birth trauma and ovariectomy on the gene expression of detrusor muscarinic receptors in female rats
    Cheng Yu Long
    Graduate Institute of Medicine, Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Int Urogynecol J 21:1163-8. 2010
  3. ncbi Effect of estrogen on muscarinic acetylcholine receptor expression in rat myometrium
    Fernando M F Abdalla
    Laboratory of Pharmacology, Instituto Butantan, Sao Paulo, SP, Brazil
    Mol Cell Endocrinol 213:139-48. 2004
  4. ncbi Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor
    Sung Jun Han
    Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:24870-9. 2005
  5. ncbi Identification of a family of muscarinic acetylcholine receptor genes
    T I Bonner
    Science 237:527-32. 1987
  6. ncbi Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean
    M Yamada
    Laboratory of Bioorganic Chemistry, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Nature 410:207-12. 2001
  7. doi Muscarinic signaling in the brain
    Alexander Thiele
    Institute of Neuroscience, Henry Wellcome Building, Newcastle University, Newcastle upon Tyne, United Kingdom
    Annu Rev Neurosci 36:271-94. 2013
  8. ncbi Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor
    Sung Jun Han
    Molecular Signaling and Molecular Recognition Sections, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 0810, USA
    J Biol Chem 280:34849-58. 2005
  9. pmc CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function
    Ming Lei Guo
    Department of Basic Medical Science, University of Missouri Kansas City, Kansas City, MO, USA
    EMBO J 29:2070-81. 2010
  10. doi Generation of an agonistic binding site for blockers of the M(3) muscarinic acetylcholine receptor
    Doreen Thor
    Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Biochem J 412:103-12. 2008

Scientific Experts

  • Alexander Thiele
  • Yanjie Lu
  • K Asano
  • Satoko Oda
  • Francisco Botella-Romero
  • Polina A Selivanova
  • Jurgen Wess
  • Balakrishnan Savitha
  • C S Paulose
  • Jianxin Hu
  • George Naijil
  • Sung Jun Han
  • Yong Zhang
  • Doreen Thor
  • Yu Ping Wang
  • Peng Zhou Hang
  • Fadi F Hamdan
  • S V Tapilina
  • T R Anju
  • Raphael Caio Tamborelli Garcia
  • Yang Ting Dong
  • Vivien Kauschke
  • Charles D Anderson
  • Chinthu Romeo
  • Kenneth A Jacobson
  • Soo Kyung Kim
  • Bo Li
  • Andrew C Kruse
  • Thiago M Batista
  • Tong Liu
  • Valeria A Miozza
  • Federica De Angelis
  • Sharon Weiss
  • Zhenyu Pan
  • Hai e Chen
  • Everardo M Carneiro
  • Antony Sherin
  • Peeyush T Kumar
  • Antonio C Boschero
  • Lanh M Bloodworth
  • Alan S Braverman
  • Chiramadathikudiyil S Paulose
  • Shuxiang Zhang
  • Flavia M M Paula
  • Ming Lei Guo
  • M Amar
  • Savitha Balakrishnan
  • Cheng Yu Long
  • Turgut Emrah Bozkurt
  • Li hua Sun
  • Jagmohan Singh
  • Ting Ting Yang
  • Maureen Basha
  • Zhaoyang Xiao
  • Francisco Botella Romero
  • Zhi min Du
  • M C Andersson
  • Abu Syed Md Anisuzzaman
  • Ling Hung Lin
  • S Haag
  • Yu Zou
  • Paul Abrams
  • Elfaridah P Frazier
  • Violaine Simon
  • Yuen Keng Ng
  • Michael R Ruggieri
  • Francois J Michel
  • T R Renuka
  • Tobi L Limke
  • Fernando M F Abdalla
  • Mariana Aguilera Alencar da Silva
  • Lívia Mendonça Munhoz Dati
  • Renata Gorjao
  • Rosana Camarini
  • Colleen M Niswender
  • Larissa Helena Torres
  • Maria Regina Lopes Sandoval
  • Tania Marcourakis
  • Zhi zhong Guan
  • D V abramochkin
  • Qi Fang Zhang
  • P Jeffrey Conn
  • Ya Wang
  • Na Wei
  • Solange Castro Afeche
  • Mariana Sayuri Berto Udo
  • José Luiz da Costa
  • Fernando Maurício Francis Abdalla
  • Mauricio Yonamine
  • Sunila Mahavadi

Detail Information

Publications70

  1. pmc Immunoglobulins from scleroderma patients inhibit the muscarinic receptor activation in internal anal sphincter smooth muscle cells
    Jagmohan Singh
    Department of Medicine, Thomas Jefferson Univ, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1206-13. 2009
    ..These data suggest that SSc GI dysmotility may be caused by autoantibodies that inhibit the muscarinic neurotransmission. Future treatment of SSc patients may be directed at the removal or neutralization of these antibodies...
  2. doi The impact of simulated birth trauma and ovariectomy on the gene expression of detrusor muscarinic receptors in female rats
    Cheng Yu Long
    Graduate Institute of Medicine, Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Int Urogynecol J 21:1163-8. 2010
    ..This study aims to investigate the effects of simulated birth trauma and ovariectomy on detrusor muscarinic receptors (M2 and M3), urethral neuronal nitric oxide synthase (nNOS), and estrogen receptor beta (ER beta)...
  3. ncbi Effect of estrogen on muscarinic acetylcholine receptor expression in rat myometrium
    Fernando M F Abdalla
    Laboratory of Pharmacology, Instituto Butantan, Sao Paulo, SP, Brazil
    Mol Cell Endocrinol 213:139-48. 2004
    ..In conclusion, these results provide evidence for the presence of M(2)- and M(3)-mAChR, at the mRNA and protein level, in the rat myometrium and indicate that estrogen induces an increase in myometrial responsiveness to mAChR agonists...
  4. ncbi Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor
    Sung Jun Han
    Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:24870-9. 2005
    ..These findings should be of relevance for other family A GPCRs...
  5. ncbi Identification of a family of muscarinic acetylcholine receptor genes
    T I Bonner
    Science 237:527-32. 1987
    ..This gene family provides a new basis for evaluating the diversity of muscarinic mechanisms in the nervous system...
  6. ncbi Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean
    M Yamada
    Laboratory of Bioorganic Chemistry, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Nature 410:207-12. 2001
    ..Our data indicate that there may be a cholinergic pathway that involves M3-receptor-mediated facilitation of food intake at a site downstream of the hypothalamic leptin/melanocortin system and upstream of the MCH system...
  7. doi Muscarinic signaling in the brain
    Alexander Thiele
    Institute of Neuroscience, Henry Wellcome Building, Newcastle University, Newcastle upon Tyne, United Kingdom
    Annu Rev Neurosci 36:271-94. 2013
    ..This review outlines possible scenarios to describe how it contributes to cellular mechanisms of attention and how it affects channeling of information in different neuronal circuits. ..
  8. ncbi Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor
    Sung Jun Han
    Molecular Signaling and Molecular Recognition Sections, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 0810, USA
    J Biol Chem 280:34849-58. 2005
    ..To the best of our knowledge, this is the first direct demonstration of a conformational change occurring in the immediate vicinity of the binding site of a GPCR activated by a diffusible ligand...
  9. pmc CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function
    Ming Lei Guo
    Department of Basic Medical Science, University of Missouri Kansas City, Kansas City, MO, USA
    EMBO J 29:2070-81. 2010
    ..Our data identify a new model of protein-protein interactions. In a Ca(2+)-sensitive manner, CaMKIIalpha regulates M4R efficacy and controls the acetylcholine-dopamine balance in the basal ganglia and also the dynamics of movement...
  10. doi Generation of an agonistic binding site for blockers of the M(3) muscarinic acetylcholine receptor
    Doreen Thor
    Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Biochem J 412:103-12. 2008
    ..Our results indicate that blocker-to-agonist converting mutations enable atropine to function as both agonist and antagonist by interaction with two functionally distinct binding sites...
  11. doi Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats
    Ting Ting Yang
    Graduate Institute of Basic Medical Science, China Medical University, Taichung City, Taiwan, ROC
    Neurosci Lett 451:57-9. 2009
    ..Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue...
  12. doi Cholinergic receptor alterations in the brain stem of spinal cord injured rats
    Chinthu Romeo
    Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Kochi 682 022, Kerala, India
    Neurochem Res 38:389-97. 2013
    ..The significant reduction in brain stem cholinergic function might have intensified the motor dysfunction and locomotor disabilities...
  13. pmc Expression of muscarinic acetylcholine receptors M3 and M5 in osteoporosis
    Vivien Kauschke
    Laboratory of Experimental Trauma Surgery, Justus Liebig University Giessen, Giessen, Germany
    Med Sci Monit 20:869-74. 2014
    ..Thus, in the present study we investigated the relative mRNA expression of M3 and M5 mAChR in bones of a rat osteoporosis model...
  14. doi Deficit in learning and memory of rats with chronic fluorosis correlates with the decreased expressions of M1 and M3 muscarinic acetylcholine receptors
    Yang Ting Dong
    Department of Pathology in the Affiliated Hospital, Guiyang Medical University, Guiyang, 550004, People s Republic of China
    Arch Toxicol 89:1981-91. 2015
    ....
  15. doi Cortical cholinergic dysregulation as a long-term consequence of neonatal hypoglycemia
    T R Anju
    Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin 682022 Kerala, India
    Biochem Cell Biol 93:47-53. 2015
    ....
  16. pmc Role of various kinases in muscarinic M3 receptor-mediated contraction of longitudinal muscle of rat colon
    Charles D Anderson
    Department of Physiology and Biophysics, VCU Program in Enteric Neuromuscular Sciences, Virginia Commonwealth University, USA
    J Smooth Muscle Res 50:103-19. 2014
    ....
  17. doi Different Myocardial Sensitivity in Newborn and Mature Rats to Selective Stimulation of M3 Cholinoreceptors
    S V Tapilina
    Department of Human and Animal Physiology, M V Lomonosov Moscow State University, Moscow, Russia
    Bull Exp Biol Med 159:8-10. 2015
    ..While stimulation of ventricular M3 cholinoreceptors with pilocarpine was significantly stronger in newborn pups than in mature rats, similar stimulation of atrial receptors revealed no significant difference in both groups. ..
  18. pmc M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product
    Raphael Caio Tamborelli Garcia
    Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 580, bl 13B, 05508 000, Sao Paulo SP, Brazil
    Sci Rep 5:17555. 2015
    ....
  19. doi Taurine supplementation restores glucose and carbachol-induced insulin secretion in islets from low-protein diet rats: involvement of Ach-M3R, Synt 1 and SNAP-25 proteins
    Thiago M Batista
    Departamento de Anatomia, Biologia Celular e Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil 13083 865
    J Nutr Biochem 23:306-12. 2012
    ..The latter effect involves the normalization of the cholinergic pathway, associated with the preservation of exocytotic proteins...
  20. pmc Structural aspects of M₃ muscarinic acetylcholine receptor dimer formation and activation
    Jianxin Hu
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892 0810, USA
    FASEB J 26:604-16. 2012
    ..Given the high degree of structural homology among family A GPCRs, these findings should be of broad significance...
  21. pmc Modulation of distinct isoforms of L-type calcium channels by G(q)-coupled receptors in Xenopus oocytes: antagonistic effects of Gβγ and protein kinase C
    Sharon Weiss
    Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Channels (Austin) 6:426-37. 2012
    ..Our results suggest a complex antagonistic interplay between G(q)-activated PKC and Gβγ in regulation of L-VDCC, in which multiple cytosolic segments of α(1C) are involved...
  22. doi Influence of experimental periodontitis on cholinergic stimulation of K⁺ release in rat parotid glands
    Valeria A Miozza
    Pharmacology, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina
    Auton Neurosci 169:43-8. 2012
    ..These findings agree with the fact that a decrease of fluid secretion is not a condition of patients with periodontal disease...
  23. pmc Structure and dynamics of the M3 muscarinic acetylcholine receptor
    Andrew C Kruse
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305, USA
    Nature 482:552-6. 2012
    ..Our findings not only offer insights into the structure and function of one of the most important GPCR families, but may also facilitate the design of improved therapeutics targeting these critical receptors...
  24. pmc M3 subtype of muscarinic acetylcholine receptor promotes cardioprotection via the suppression of miR-376b-5p
    Zhenyu Pan
    Department of Pharmacology, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People s Republic of China
    PLoS ONE 7:e32571. 2012
    ..These findings provide new insight into the potential mechanism by which M(3)-mAChR provides cardioprotection against myocardial ischemia injury...
  25. doi Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation, and differentiation
    Federica De Angelis
    Department of Biology and Biotechnologies Charles Darwin, Center of Neurobiology Research Daniel Bovet, La Sapienza University of Rome, Rome, Italy
    Dev Neurobiol 72:713-28. 2012
    ..This hypothesis is further supported by increased expression of Notch-1 in OL on muscarinic activation...
  26. doi Identification of M(1) muscarinic receptor subtype in rat stomach using a tissue segment binding method, and the effects of immobilization stress on the muscarinic receptors
    Abu Syed Md Anisuzzaman
    Division of Pharmacology, Department of Biochemistry and Bioinformative Sciences, University of Fukui, School of Medicine, Eiheiji Matsuoka, Fukui 910 1193, Japan
    Eur J Pharmacol 599:146-51. 2008
    ..Careful identification of native in vivo muscarinic receptors may further elucidate their functions in stomach...
  27. ncbi [Changes of nerve growth factor and M3 subtype muscarinic receptor in the seminal vesicle of diabetic rats]
    Hai e Chen
    Research Institute of Family Planning, Tongjin Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Zhonghua Nan Ke Xue 17:1002-6. 2011
    ....
  28. doi Vitamin D3 restores altered cholinergic and insulin receptor expression in the cerebral cortex and muscarinic M3 receptor expression in pancreatic islets of streptozotocin induced diabetic rats
    Peeyush T Kumar
    Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Cochin University of Science and Technology, Cochin, Kerala 682 022, India
    J Nutr Biochem 22:418-25. 2011
    ....
  29. doi Blockade of different muscarinic receptor subtypes changes the equilibrium between excitation and inhibition in rat visual cortex
    M Amar
    CNRS, Institut de Neurobiologie Alfred Fessard FRC2118, Laboratoire de Neurobiologie Cellulaire et Moléculaire UPR9040, Gif sur Yvette Cedex, F 91198, France
    Neuroscience 169:1610-20. 2010
    ..The activation of the different types of MRs located either on glutamatergic neurons or on GABAergic interneurons converges to reinforce the dominance of inhibitory inputs thus decreasing the excitability of layer 5 pyramidal neurons...
  30. doi Requirement of NF-kappaB signalling pathway for modulation of the cholinergic muscarinic M3 receptor expression by INGAP-PP in insulin-producing cells
    Flavia M M Paula
    Department of Physiology and Biophysics, Institute of Biology, State University of Campinas, UNICAMP, Campinas 13083 970, Brazil
    Eur J Pharmacol 642:37-46. 2010
    ..NF-kappaB signalling plays an essential role in controlling the expression of the muscarinic M(3) receptor...
  31. doi Muscarinic M₁, M₃ receptor modulation in the corpus striatum of streptozotocin induced diabetic rats as a function of age
    Balakrishnan Savitha
    Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, India
    J Pharm Pharmacol 62:1768-75. 2010
    ..In this study we have investigated muscarinic M₁, M₃ receptor kinetics and the functional role of IP3 and cGMP in the corpus striatum of both young and old diabetic and insulin-treated diabetic rats...
  32. doi Morphological and molecular characteristics of "difficult" asthma
    Polina A Selivanova
    Department of Therapy, Siberian State Medical University, Tomsk 634050, Russian Federation
    J Asthma 47:269-75. 2010
    ....
  33. ncbi Distinct roles of cholinergic receptors in small cell lung cancer cells
    Shuxiang Zhang
    Department of Respiratory Medicine and Research Institute for Diseases of Old Ages, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Anticancer Res 30:97-106. 2010
    ....
  34. doi The effects of abnormalities of glucose homeostasis on the expression and binding of muscarinic receptors in cerebral cortex of rats
    Antony Sherin
    Department of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, India
    Eur J Pharmacol 651:128-36. 2011
    ..Hypoglycemia exacerbated the neurochemical changes in cerebral cortex induced by hyperglycemia. These findings have implications for both therapy and identification of causes contributing to neuronal dysfunction in diabetes...
  35. pmc Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro
    Kazuhito Asano
    Division of Physiology, School of Nursing and Rehabilitation Sciences, Showa University Northern Yokohama Hospital, Yokohama, Japan
    Int J Chron Obstruct Pulmon Dis 3:781-9. 2008
    ..There is also increasing evidence that metalloproteinases (MMPs) may contribute to the pathogenesis of COPD, but the influence of agents that used for the treatment of COPD is not well understood...
  36. pmc Functional significance of muscarinic receptor expression within the proximal and distal rat vagina
    Maureen Basha
    Department of Pharmacology and Physiology, Drexel University College of Medicine Philadelphia, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1486-93. 2009
    ..Our results provide strong evidence for the functional significance of M(3) receptor expression in the vaginal muscularis...
  37. doi Reciprocal regulation between M3 muscarinic acetylcholine receptor and protein kinase C-epsilon in ventricular myocytes during myocardial ischemia in rats
    Peng Zhou Hang
    Institute of Clinical Pharmacology of Second Hospital, Harbin Medical University, Key Laboratory of Heilongjiang Province, Baojian Road 157, Nangang District, Harbin, Heilongjiang Province, 150081, People s Republic of China
    Naunyn Schmiedebergs Arch Pharmacol 380:443-50. 2009
    ..This reciprocal regulation is likely to play a role in heart signal transduction during ischemia between ventricular myocytes...
  38. doi Cholinergic and glutamergic receptor functional regulation in long-term, low dose somatotropin and insulin treatment to ageing rats: rejuvenation of brain function
    Savitha Balakrishnan
    Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin 682 022, Kerala, India
    Mol Cell Endocrinol 314:23-30. 2010
    ..The results highlight long-term low dose somatotropin and insulin treatment in regulating cholinergic and glutamergic receptors subtypes in ageing rats and rejuvenation of brain function...
  39. doi [Characterization of muscarinic receptors in undifferentiated thyroid cells in Fisher rats]
    Francisco Botella Romero
    Sección de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Albacete, Facultad de Medicina, Universidad de Castilla La Mancha, Albacete, Espana
    Endocrinol Nutr 56:106-11. 2009
    ..Controversy surrounds receptor characterization in thyroid cells...
  40. ncbi Alterations in the muscarinic M1 and M3 receptor gene expression in the brain stem during pancreatic regeneration and insulin secretion in weanling rats
    T R Renuka
    Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, 682 022, Kerala, India
    Life Sci 75:2269-80. 2004
    ..Central muscarinic M1 and M3 receptor subtypes functional balance is suggested to regulate sympathetic and parasympathetic activity, which in turn control the islet cell proliferation and glucose homeostasis...
  41. pmc Site-directed mutagenesis of the m3 muscarinic receptor: identification of a series of threonine and tyrosine residues involved in agonist but not antagonist binding
    J Wess
    National Institute of Neurological Disorders and Stroke, Laboratory of Molecular Biology, Bethesda, MD 20892
    EMBO J 10:3729-34. 1991
    ....
  42. ncbi Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation
    E Kurtenbach
    Division of Physical Biochemistry, National Institute for Medical Research, Mill Hill, London, United Kingdom
    J Biol Chem 265:13702-8. 1990
    ....
  43. ncbi A novel subtype of muscarinic receptor identified by homology screening
    T Braun
    Laboratory of Molecular Neurobiology, ZMBH, University of Heidelberg, F R G
    Biochem Biophys Res Commun 149:125-32. 1987
    ..The existence of multiple receptor subtypes encoded by distinct genes in the brain has functional implications for the molecular mechanisms underlying information transmission in neuronal networks...
  44. ncbi Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes
    T I Bonner
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20982
    Neuron 1:403-10. 1988
    ..Expression of mRNA has yet to be observed in brain or selected peripheral tissues, suggesting that either it is substantially less abundant than m1-m4 or its distribution is quite different...
  45. pmc Mediation by M3-muscarinic receptors of both endothelium-dependent contraction and relaxation to acetylcholine in the aorta of the spontaneously hypertensive rat
    C M Boulanger
    Center for Experimental Therapeutics, Baylor College of Medicine, Houston, Texas 77030
    Br J Pharmacol 112:519-24. 1994
    ..15 +/- 0.23 and 9.63 +/- 0.28, respectively. These results suggest that the muscarinic M3 receptor subtype mediates both endothelium-dependent relaxation and contraction to acetylcholine in SHR aorta...
  46. ncbi Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies
    S M Hersch
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322
    J Neurosci 14:3351-63. 1994
    ....
  47. ncbi The M3-muscarinic cholinoceptor subtype in rat prostate and its down regulation by aging
    H Yazawa
    Central Research Laboratories, Yamanouchi Pharmaceutical Co, Ltd, Tokyo, Japan
    Jpn J Pharmacol 61:319-24. 1993
    ..However, KD values for muscarinic cholinoceptors, and Bmax and KD values for beta-adrenoceptors showed no change. These results suggest that the number of prostatic muscarinic cholinoceptors decreases with aging...
  48. pmc Mediation by the same muscarinic receptor subtype of phasic and tonic contractile activities in the rat isolated portal vein
    M Pfaffendorf
    Department of Pharmacotherapy, University of Amsterdam, The Netherlands
    Br J Pharmacol 108:132-8. 1993
    ..Since the EC50-values for both carbachol-induced effects were different (phasic0.232 +/- 0.02 1AM; tonic 2.75 +/- 0.1 1AM) the phasic type of response appears to involve a large receptor reserve...
  49. ncbi Differentiation of muscarinic receptors mediating negative chronotropic and vasoconstrictor responses to acetylcholine in isolated rat hearts
    D B Hoover
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA
    J Pharmacol Exp Ther 282:1337-44. 1997
    ..Furthermore, they provide evidence that the M3 receptor subtype mediates the vasoconstrictor effect of acetylcholine on resistance vessels in rat heart...
  50. ncbi Molecular cloning of m3 muscarinic acetylcholine receptor in rat iris
    M Furuta
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan
    J Smooth Muscle Res 34:111-22. 1998
    ..It was found that iris m3 is slightly but substantially different in amino acid sequence from that in brain of the rat...
  51. ncbi Use of an in situ disulfide cross-linking strategy to map proximities between amino acid residues in transmembrane domains I and VII of the M3 muscarinic acetylcholine receptor
    Fadi F Hamdan
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 8 Center Drive, Bethesda, Maryland 20892, USA
    Biochemistry 41:7647-58. 2002
    ..Alternatively, dynamic protein backbone fluctuation may occur, enabling Cys532 to move within cross-linking distance of Leu77 (Cys77)...
  52. pmc Interaction between muscarinic receptor subtype signal transduction pathways mediating bladder contraction
    Alan S Braverman
    Department of Urology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Am J Physiol Regul Integr Comp Physiol 283:R663-8. 2002
    ..Thus in normal bladders both M(2) and M(3) receptors can induce contraction. In the denervated bladder, the M(2) and the M(3) receptors interact in a facilitatory manner to mediate contraction...
  53. ncbi Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus
    Jeffrey Tseng
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Hear Res 174:86-92. 2002
    ..The m1-m5 muscarinic subtypes mapped to the following chromosomes: Chrm1, chromosome 1; Chrm2, chromosome 4; Chrm3, chromosome 17; Chrm4, chromosome 3; and Chrm5, chromosome 3...
  54. pmc Regulation of rat mesencephalic GABAergic neurones through muscarinic receptors
    Francois J Michel
    Departement de Pharmacologie, Faculte de Medecine, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada
    J Physiol 556:429-45. 2004
    ..Our findings provide new data that should be helpful in better understanding the influence of local GABAergic neurones during cholinergic activation of mesencephalic circuits...
  55. ncbi Acute exposure to methylmercury causes Ca2+ dysregulation and neuronal death in rat cerebellar granule cells through an M3 muscarinic receptor-linked pathway
    Tobi L Limke
    Department of Pharmacology and Toxicology, Institute for Environmental Toxicology, and Neuroscience Program, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 80:60-8. 2004
    ..Thus activation of M3 muscarinic receptors with subsequent generation of IP3 evidently contributes to elevated [Ca2+]i and subsequent cytotoxicity of cerebellar granule cells by MeHg...
  56. doi Acetylcholine and muscarinic receptor function in cerebral cortex of diabetic young and old male Wistar rats and the role of muscarinic receptors in calcium release from pancreatic islets
    Balakrishnan Savitha
    Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, India
    Biogerontology 11:151-66. 2010
    ..Thus our studies suggest that Insulin signaling play an important part in differentially regulating pancreatic cholinergic activity, and the diabetes mediated cortical dysfunctions with age...
  57. ncbi Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor
    Bo Li
    Department of Molecular Signaling, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, 8 Center Dr, Bethesda, MD 20892, USA
    J Biol Chem 280:5664-75. 2005
    ..Our data suggest a conformational link between the highly conserved Asp-113, Arg-165, and Tyr-250 residues which is critical for receptor activation...
  58. pmc Muscarinic regulation of neonatal rat bladder spontaneous contractions
    Yuen Keng Ng
    Department of Surgery, University of Hong Kong, Hong Kong
    Am J Physiol Regul Integr Comp Physiol 291:R1049-59. 2006
    ....
  59. pmc The proto-oncogene SET interacts with muscarinic receptors and attenuates receptor signaling
    Violaine Simon
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 281:40310-20. 2006
    ..These data provide expanded functionality for SET and a previously unrecognized mechanism for regulation of GPCR signaling capacity...
  60. pmc Does phospholipase C mediate muscarinic receptor-induced rat urinary bladder contraction?
    Elfaridah P Frazier
    Department of Pharmacology and Pharmacotherapy, University of Amsterdam, The Netherlands
    J Pharmacol Exp Ther 322:998-1002. 2007
    ..We conclude that previously reported differences relate to the use of inhibitors rather than experimental protocols and that the overall data do not support a role for PLC in M(3) muscarinic receptor-mediated rat bladder contraction...
  61. ncbi Immunolocalization of muscarinic receptor subtypes in the reticular thalamic nucleus of rats
    Satoko Oda
    Department of Anatomy, Toho University School of Medicine, Tokyo, Japan
    Brain Res Bull 74:376-84. 2007
    ..These results show the different distributions of m2 and m3 in rRt neurons, and strongly suggest that m2 is more closely associated with cholinergic afferents than m3...
  62. ncbi Muscarinic receptor antagonists for overactive bladder
    Paul Abrams
    Bristol Urological Institute, Southmead Hospital, Bristol, UK
    BJU Int 100:987-1006. 2007
    ....
  63. pmc Cholinergic nitric oxide release from the urinary bladder mucosa in cyclophosphamide-induced cystitis of the anaesthetized rat
    M C Andersson
    Department of Pharmacology, The Sahlgrenska Academy at Goteborg University, Gothenburg, Sweden
    Br J Pharmacol 153:1438-44. 2008
    ..In the current study, we evaluated the effects of cyclophosphamide-induced cystitis on muscarinic whole bladder contractile responses in vivo, and further, if NO might be released from the mucosa by cholinergic stimuli...
  64. doi Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airway hyperresponsiveness
    Ling Hung Lin
    Department of Dentistry, Taipei Medical University Hospital, Taipei 110, Taiwan
    Eur J Pharmacol 584:398-404. 2008
    ..In conclusion, S-isopetasin may be beneficial as a bronchodilator in the treatment of chronic obstructive pulmonary disease and asthma exacerbations...
  65. doi Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts
    S Haag
    Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
    Eur Respir J 32:555-62. 2008
    ..Prolonged blockade of muscarinic-induced collagen synthesis may contribute to reported beneficial long-term effects of anticholinergics in chronic obstructive pulmonary disease...
  66. ncbi [Expression change of Muscarinic receptor subunits in rat flocculus following unilateral labyrinthectomy]
    Yu Zou
    Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 22:896-8, 903. 2008
    ..To observe the expression of Muscarinic receptor M1, M3, M5 subunits in rat flocculus following left unilateral labyrinthectomy (UL)...
  67. ncbi Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants
    J Wess
    National Institute of Neurological Disorders and Stroke, Laboratory of Molecular Biology, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 267:19313-9. 1992
    ....
  68. doi M(1) and M(3) muscarinic receptors are involved in the release of urinary bladder-derived relaxant factor
    Turgut Emrah Bozkurt
    Hacettepe University, Faculty of Pharmacy, Department of Pharmacology, 06100 Sihhiye, Ankara, Turkey
    Pharmacol Res 59:300-5. 2009
    ..In addition, McN-A-343, by activating the facilitatory M(1) receptors and physostigmine by inhibiting the acetylcholinesterase may induce the release of this factor through endogenous acetylcholine in the coaxial bioassay system...
  69. doi M3 muscarinic acetylcholine receptor is associated with beta-catenin in ventricular myocytes during myocardial infarction in the rat
    Yu Ping Wang
    Institute of Clinical Pharmacology of Second Hospital, Harbin Medical University, Harbin, PR China
    Clin Exp Pharmacol Physiol 36:995-1001. 2009
    ..4. The results indicate that increased beta-catenin activity is associated with M(3) mAChR during MI. This association is likely to play a role in heart signal transduction during ischaemia between neighbouring ventricular myocardiocum...
  70. pmc Modulation of GABAergic transmission by muscarinic receptors in the entorhinal cortex of juvenile rats
    Zhaoyang Xiao
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58203, USA
    J Neurophysiol 102:659-69. 2009
    ..Our results demonstrate that activation of muscarinic receptors exerts diverse effects on GABAergic transmission in the EC...