Chi3l1

Summary

Gene Symbol: Chi3l1
Description: chitinase 3 like 1
Alias: CGP-39, Chil1, GP-39, chitinase-3-like protein 1, cartilage glycoprotein 39, chitinase 3-like 1 (cartilage glycoprotein-39), chitinase 3-like 1 protein
Species: rat

Top Publications

  1. ncbi Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer
    Catherine S M Diefenbach
    Gynecologic Medical Oncology, Department of Medicine, Howard 903, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gynecol Oncol 104:435-42. 2007
  2. ncbi A chitinase-like protein in the lung and circulation of patients with severe asthma
    Geoffrey L Chupp
    Yale University School of Medicine, New Haven, CT, USA
    N Engl J Med 357:2016-27. 2007
  3. ncbi Serum YKL-40 levels in patients with coronary artery disease
    Mine Kucur
    Fikret Biyal Research Laboratory, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey
    Coron Artery Dis 18:391-6. 2007
  4. doi Serum levels of YKL-40 increases in patients with acute myocardial infarction
    Camilla Nøjgaard
    Department of Gastroenterology, Hvidovre Hospital, Denmark
    Coron Artery Dis 19:257-63. 2008
  5. pmc YKL-40, a marker of inflammation and endothelial dysfunction, is elevated in patients with type 1 diabetes and increases with levels of albuminuria
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Diabetes Care 32:323-8. 2009
  6. pmc YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis
    Christian Østergaard
    Division of Microbiology, Department of Research and Development, Statens Serum Institut, Copenhagen, Denmark
    Clin Diagn Lab Immunol 9:598-604. 2002
  7. pmc Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:1149-66. 2009
  8. ncbi Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity?
    Julia S Johansen
    Department of Rheumatology, Herlev Hospital, University of Copenhagen, Denmark
    Respir Med 99:396-402. 2005
  9. ncbi YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization
    C Nordenbaek
    Department of Internal Medicine, Section of Rheumatology, Odense University Hospital, DK 5000 Odense, Denmark
    J Infect Dis 180:1722-6. 1999
  10. pmc Co-Expression and Co-Localization of Cartilage Glycoproteins CHI3L1 and Lubricin in Osteoarthritic Cartilage: Morphological, Immunohistochemical and Gene Expression Profiles
    Marta Anna Szychlinska
    Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S Sofia 87, 95123 Catania, Italy
    Int J Mol Sci 17:359. 2016

Research Grants

Scientific Experts

  • J S Johansen
  • Camilla N Rathcke
  • Estrid Høgdall
  • Claudia Nordenbæk
  • G L Chupp
  • Riza Madazli
  • Anne K Mylin
  • Hidefumi Waki
  • Anneliese D Recklies
  • Susanne Samuelsson
  • Olav J Bergmann
  • Nicoline M Korthagen
  • Hiroshi Matsuura
  • Chun Geun Lee
  • Jack A Elias
  • Myung Hyun Sohn
  • Paul A Price
  • Marta Anna Szychlinska
  • C Nordenbaek
  • Venkataswarup Tiriveedhi
  • Ting Hsien Kao
  • Ib Jarle Christensen
  • Oscar Pizano-Martínez
  • Min Jong Kang
  • Stine B Thomsen
  • Dominik Hartl
  • Barbara Koller
  • Ina Thom
  • Robert J Homer
  • Camilla Nøjgaard
  • Zhongyuan Jin
  • Mine Kucur
  • Catherine S M Diefenbach
  • Klaus Brasso
  • Henrik Schmidt
  • Giuseppe Musumeci
  • Lidia Puzzo
  • Helene Sjögren
  • Michelino Di Rosa
  • Lucia Malaguarnera
  • Paola Castrogiovanni
  • Francesca Maria Trovato
  • Rosy Leonardi
  • Gundumi A Upadhya
  • Christian Østergaard
  • Jeff N Dines
  • Herng Sheng Lee
  • Bret L Knolhoff
  • Christopher D Anderson
  • Sabarinathan Ramachandran
  • Yi Jen Peng
  • Jianluo Jia
  • Donald M Salter
  • P A Price
  • Christina Cintin
  • Nayan J Sarma
  • Thallachallour Mohanakumar
  • William C Chapman
  • Rebecca A Busch
  • Hsi Kai Tsou
  • Kristen L Gunter
  • Y Huang
  • J M Markert
  • Charles S Dela Cruz
  • Mary Fafutis-Morris
  • Won Kyung Cho
  • Mónica Vázquez-Del Mercado
  • Pablo C Ortiz-Lazareno
  • Pilar Alatorre-Carranza
  • Adrian Daneri-Navarro
  • Vidal Delgado-Rizo
  • Irinea Yañez-Sánchez
  • Yang Zhou
  • Alejandra Miranda-Díaz
  • Trinidad Garcia-Iglesias
  • Ning Yuan Chen
  • Carsten Bokemeyer
  • Gunter Schuch
  • Birte Andritzky
  • Udo Schumacher
  • Henrik Vestergaard
  • Bo Zerahn
  • Lutz Edler
  • Iris Burkholder
  • Eckart Laack
  • Vineet Bhandari
  • Gap Ryol Lee
  • Carla A Da Silva
  • Jennifer Reed
  • Alexander A Kozhich

Detail Information

Publications39

  1. ncbi Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer
    Catherine S M Diefenbach
    Gynecologic Medical Oncology, Department of Medicine, Howard 903, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gynecol Oncol 104:435-42. 2007
    ..In this study, we examined the frequency of serum elevation as well as the diagnostic and prognostic significance of this serum marker in endometrial cancer...
  2. ncbi A chitinase-like protein in the lung and circulation of patients with severe asthma
    Geoffrey L Chupp
    Yale University School of Medicine, New Haven, CT, USA
    N Engl J Med 357:2016-27. 2007
    ..The related chitinase-like protein, YKL-40 (also called human cartilage glycoprotein 39 [HCgp-39] and chitinase 3-like 1), can be readily measured in the serum...
  3. ncbi Serum YKL-40 levels in patients with coronary artery disease
    Mine Kucur
    Fikret Biyal Research Laboratory, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey
    Coron Artery Dis 18:391-6. 2007
    ..Moreover, our findings revealed that plasma YKL-40 measurement might also be regarded as a quantitative indicator of disease extent besides being a marker of disease presence...
  4. doi Serum levels of YKL-40 increases in patients with acute myocardial infarction
    Camilla Nøjgaard
    Department of Gastroenterology, Hvidovre Hospital, Denmark
    Coron Artery Dis 19:257-63. 2008
    ..The aim was to examine the sequential changes in serum YKL-40 in patients with acute myocardial infarction (AMI), with and without thrombolytic therapy, as compared with patients with stable coronary artery disease (CAD)...
  5. pmc YKL-40, a marker of inflammation and endothelial dysfunction, is elevated in patients with type 1 diabetes and increases with levels of albuminuria
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Diabetes Care 32:323-8. 2009
    ..In the present study, YKL-40 levels were examined in patients with type 1 diabetes with increasing levels of albuminuria, known to be associated with an increased risk of cardiovascular disease...
  6. pmc YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis
    Christian Østergaard
    Division of Microbiology, Department of Research and Development, Statens Serum Institut, Copenhagen, Denmark
    Clin Diagn Lab Immunol 9:598-604. 2002
    ..In conclusion, high levels of YKL-40 in CSF are found in patients with purulent meningitis...
  7. pmc Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:1149-66. 2009
    Mouse breast regression protein 39 (BRP-39; Chi3l1) and its human homologue YKL-40 are chitinase-like proteins that lack chitinase activity...
  8. ncbi Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity?
    Julia S Johansen
    Department of Rheumatology, Herlev Hospital, University of Copenhagen, Denmark
    Respir Med 99:396-402. 2005
    ....
  9. ncbi YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization
    C Nordenbaek
    Department of Internal Medicine, Section of Rheumatology, Odense University Hospital, DK 5000 Odense, Denmark
    J Infect Dis 180:1722-6. 1999
    ....
  10. pmc Co-Expression and Co-Localization of Cartilage Glycoproteins CHI3L1 and Lubricin in Osteoarthritic Cartilage: Morphological, Immunohistochemical and Gene Expression Profiles
    Marta Anna Szychlinska
    Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S Sofia 87, 95123 Catania, Italy
    Int J Mol Sci 17:359. 2016
    ..Several studies reported that levels of human cartilage glycoprotein chitinase 3-like-1 (CHI3L1) are known as a potential marker for the activation of chondrocytes and the progression of Osteoarthritis (OA), ..
  11. doi Protective role of bortezomib in steatotic liver ischemia/reperfusion injury through abrogation of MMP activation and YKL-40 expression
    Venkataswarup Tiriveedhi
    Department of Surgery, Washington University in St Louis, School of Medicine, St Louis, MO, United States Department of Biological Sciences, Tennessee State University, Nashville, TN, United States Electronic address
    Transpl Immunol 30:93-8. 2014
    ....
  12. doi Nerve growth factor promotes expression of novel genes in intervertebral disc cells that regulate tissue degradation: Laboratory investigation
    Ting Hsien Kao
    Graduate Institute of Medical Science, National Defense Medical Center, and
    J Neurosurg Spine 21:653-61. 2014
    ..The aim of the study was to assess if nerve growth factor (NGF) might alter gene expression of IVD cells and contribute to disc degeneration by enhancing expression or activity of factors that cause breakdown of IVD matrix...
  13. pmc YKL-40 expression in CD14⁺ liver cells in acute and chronic injury
    Oscar Pizano-Martínez
    Department of Physiology, CUCS, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico
    World J Gastroenterol 17:3830-5. 2011
    ..To demonstrate that CD14⁺ cells are an important source of the growth factor YKL-40 in acute and chronic liver damage...
  14. pmc Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema
    Hiroshi Matsuura
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    Am J Respir Cell Mol Biol 44:777-86. 2011
    ..These studies also underscore that maintaining physiologic concentrations of YKL-40 in the lung is therapeutically important in preventing excessive inflammatory responses or emphysematous alveolar destruction...
  15. doi Elevated pretreatment serum concentration of YKL-40-An independent prognostic biomarker for poor survival in patients with metastatic nonsmall cell lung cancer
    Ina Thom
    Department of Oncology, Hematology, and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumor Center, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Cancer 116:4114-21. 2010
    ..Consequently, high serum YKL-40 levels have been associated with a poor prognosis in patients with several cancer types. However, the role of YKL-40 has not been established in nonsmall cell lung cancer (NSCLC)...
  16. pmc The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury
    Myung Hyun Sohn
    Department of Pediatrics, and Institute of Allergy, Severance Biomedical Science Institute, BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Am J Respir Crit Care Med 182:918-28. 2010
    ..However, the regulation and roles of these molecules in hyperoxia have not been addressed...
  17. doi Serum and BALF YKL-40 levels are predictors of survival in idiopathic pulmonary fibrosis
    Nicoline M Korthagen
    Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands
    Respir Med 105:106-13. 2011
    ..The aim of this study was to investigate the potential of YKL-40 as a prognostic biomarker for survival in IPF patients...
  18. doi Plasma YKL-40 levels are elevated in patients with chronic heart failure
    Camilla Noelle Rathcke
    Department of Endocrinology, Copenhagen University Hospital Herlev, Denmark
    Scand Cardiovasc J 44:92-9. 2010
    ..We investigated plasma YKL-40 levels in patients with CHF and evaluated the possible predictive value with respect to overall mortality and recurrent cardiovascular outcomes...
  19. pmc Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e6106. 2009
    YKL-40 is a chitinase-like glycoprotein encoded by the chitinase 3-like 1 gene, CHI3L1, localized at chromosome 1q32.1. Increased levels of serum YKL-40 have been reported to be a biomarker for asthma and a reduced lung function...
  20. pmc Increased levels of the calcification marker matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease
    Stine B Thomsen
    Department of Medicine O, Center of Endocrinology and Metabolism, Copenhagen University Hospital Herlev, Denmark
    Cardiovasc Diabetol 9:86. 2010
    ..In the present study levels of markers of calcification (MGP) and inflammation (YKL-40, hsCRP) were evaluated in patients with T2 D and/or ischemic heart disease (IHD)...
  21. doi Gene expression profiles of major cytokines in the nucleus tractus solitarii of the spontaneously hypertensive rat
    Hidefumi Waki
    Department of Physiology, Wakayama Medical University School of Medicine, 811 1, Kimiidera, Wakayama City 641 8509, Japan
    Auton Neurosci 142:40-4. 2008
    ..These data together with our previous published finding of an over expression of junctional adhesion molecule-1 suggest that the NTS of the SHR exhibits a specific inflammatory state...
  22. ncbi Identification of differentially expressed genes in rat silicosis model by suppression subtractive hybridization analysis
    Zhongyuan Jin
    Department of Pathology, Xiangya Medical School, Central South University, Changsha 410013, China
    Acta Biochim Biophys Sin (Shanghai) 40:740-6. 2008
    ..These genes may provide new clues for investigating the molecular mechanisms in the development of pulmonary fibrosis...
  23. ncbi High serum YKL-40 level in patients with small cell lung cancer is related to early death
    Julia S Johansen
    Department of Medicine, Division of Rheumatology Q, Herlev Hospital, Herlev Ringvej 75, Herlev DK 2730, Denmark
    Lung Cancer 46:333-40. 2004
    ..02) is independent of prognostic variables for survival within the first 6 months. Studies are needed to determine the function of YKL-40 in SCLC...
  24. ncbi Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity
    J S Johansen
    Department of Rheumatology, Hvidovre Hospital, Denmark
    Rheumatology (Oxford) 38:618-26. 1999
    ..Studies have shown that YKL-40 is an autoantigen in rheumatoid arthritis (RA). We evaluated whether serum YKL-40 was related to disease activity in patients with RA...
  25. ncbi YKL-40 in giant cells and macrophages from patients with giant cell arteritis
    J S Johansen
    Department of Rheumatology, Hvidovre Hospital, Denmark
    Arthritis Rheum 42:2624-30. 1999
    ..The aim of this study was to evaluate whether macrophages and giant cells of patients with GCA produce YKL-40, and whether serum YKL-40 concentrations are elevated in these patients...
  26. ncbi Differential gene expression profiling in human brain tumors
    J M Markert
    Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Physiol Genomics 5:21-33. 2001
    ..e., MIF) may have profound implications for brain tumor cell biology and thus may identify potential useful therapeutic targets in GBMs...
  27. pmc Gene expression in papillary thyroid carcinoma reveals highly consistent profiles
    Y Huang
    Human Cancer Genetics Program, Comprehensive Cancer Center, Department of Pathology, Divisions of Sensory Biophysics and Endocrinology and Nuclear Medicine, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 98:15044-9. 2001
    ..The numerous additional genes include CITED1, CHI3L1, ODZ1, N33, SFTPB, and SCEL...
  28. ncbi High serum YKL-40 level after surgery for colorectal carcinoma is related to short survival
    Christina Cintin
    Department of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Denmark
    Cancer 95:267-74. 2002
    ..In the current study the authors evaluated the value of serum YKL-40 in monitoring patients with colorectal carcinoma...
  29. pmc Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma-cytogenetic, molecular genetic, and cDNA microarray analyses
    Helene Sjögren
    Department of Pathology, Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Am J Pathol 162:781-92. 2003
    ..The most differentially expressed gene in both tumors was CHI3L1, which encodes a secreted glycoprotein (YKL-40) previously implicated in various pathological conditions of ..
  30. ncbi High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival
    Estrid V S Høgdall
    Institute of Cancer Epidemiology, Danish Cancer Society, DK 2100 Copenhagen Ø, Denmark
    Oncol Rep 10:1535-8. 2003
    ..In conclusion, plasma levels of YKL-40 proved of prognostic value in stage III OC patients...
  31. ncbi High serum YKL-40 levels in patients with primary breast cancer is related to short recurrence free survival
    Julia S Johansen
    Connective Tissue Laboratory, Department of Rheumatology, H S Hvidovre Hospital, Denmark
    Breast Cancer Res Treat 80:15-21. 2003
    ..Further studies are required to determine the biological function of YKL-40 in breast cancer...
  32. ncbi Chitotriosidase and YKL-40 in normal and pre-eclamptic pregnancies
    Riza Madazli
    Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, Istanbul, Turkey
    Int J Gynaecol Obstet 100:239-43. 2008
    ..To compare macrophage activation in normal and pre-eclamptic pregnancies by determining YKL-40 concentration and chitotriosidase activity in maternal and cord serum...
  33. ncbi High serum levels of YKL-40 in patients with systemic sclerosis are associated with pulmonary involvement
    C Nordenbaek
    Department of Rheumatology, Hvidovre Hospital, Denmark
    Scand J Rheumatol 34:293-7. 2005
    ..The aim of the study was to determine serum YKL-40 levels in patients with systemic sclerosis (SSc) and to explore any possible clinical and prognostic associations...
  34. ncbi Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes
    Anneliese D Recklies
    Joint Diseases Laboratory, Shriners Hospital for Children, McGill University, Montreal, Quebec, Canada
    J Biol Chem 280:41213-21. 2005
    Elevated levels of CHI3L1 (chitinase-3-like protein 1) are associated with disorders exhibiting increased connective tissue turnover, such as rheumatoid arthritis, osteoarthritis, scleroderma, and cirrhosis of the liver...
  35. ncbi High serum concentration of YKL-40 is associated with short survival in patients with acute myeloid leukemia
    Olav J Bergmann
    Research Laboratory, Department of Hematology, Herlev University Hospital, Copenhagen, Denmark
    Clin Cancer Res 11:8644-52. 2005
    ..High serum YKL-40 is associated with poor prognosis in solid carcinomas. The aim was to examine serum YKL-40 in patients with acute myeloid leukemia (AML)...
  36. ncbi Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma
    Klaus Brasso
    Department of Urology, H S Rigshospitalet, University of Copenhagen, Cophenhagen, Denmark
    Prostate 66:503-13. 2006
    ..To examine the prognostic value of markers of bone metabolism (serum PINP, BAP, and CTX-I) and serum YKL-40 in metastatic prostate carcinoma (PC)...
  37. ncbi Elevated serum level of YKL-40 is an independent prognostic factor for poor survival in patients with metastatic melanoma
    Henrik Schmidt
    Department of Oncology, Aarhus University Hospital, Denmark
    Cancer 106:1130-9. 2006
    ..Its function in cancer is unknown. High serum YKL-40 levels have been associated with a poor prognosis in patients with several solid tumors. The prognostic impact of serum YKL-40 in metastatic melanoma was evaluated...
  38. ncbi Serum YKL-40 concentrations in newly diagnosed multiple myeloma patients and YKL-40 expression in malignant plasma cells
    Anne K Mylin
    Department of Haematology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Eur J Haematol 77:416-24. 2006
    A potential role in cancer biology is suggested for YKL-40 (CHI3L1, HC gp-39)...
  39. ncbi Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages
    R G Boot
    Departments of Biochemistry, and Vascular Surgery, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 19:687-94. 1999
    ..Although a function for chitotriosidase and HC gp-39 has not been identified, we hypothesize a role in cell migration and tissue remodeling during atherogenesis...

Research Grants1

  1. BIOLOGY OF IL-16 IN IL-1680 AND IL-1614 TRANSGENIC MICE
    Geoffrey Chupp; Fiscal Year: 2003
    ..These finding swill have impressive implications via-a-vis our knowledge of the biology of IL-16 and mechanisms of airway inflammation and healing in asthma. ..