Cdkn2b

Summary

Gene Symbol: Cdkn2b
Description: cyclin-dependent kinase inhibitor 2B
Alias: p15, cyclin-dependent kinase 4 inhibitor B, Cyclin dependent kinase inhibitor 2B (p15, inhibits CDK4), cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), p14-INK4b, p15-INK4b
Species: rat

Top Publications

  1. ncbi [Effect of Oviductus Ranae on Cyclin D1, CDK6 and P15 expressions in the liver tissue of aged male rats]
    Hui Yao
    College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:1044-6. 2010
  2. pmc CDKN2B, SLC19A3 and DLEC1 promoter methylation alterations in the bone marrow of patients with acute myeloid leukemia during chemotherapy
    Qingxiao Hong
    Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P R China
    Exp Ther Med 11:1901-1907. 2016
  3. ncbi CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine
    K Raj
    King s College London, Department of Haematological Medicine, Denmark Hill Campus, London, UK
    Leukemia 21:1937-44. 2007
  4. ncbi Allelic loss and promoter hypermethylation of the p15INK4b gene features in mouse radiation-induced lymphoid - but not myeloid - leukaemias
    H J Cleary
    MRC Radiation and Genome Stability Unit, Chilton, Didcot, Oxford OX11 0RD, UK
    Leukemia 13:2049-52. 1999
  5. doi Immunohistochemical determination of the P15 protein expression in cutaneous squamous cell carcinoma
    Ahmed I Moad
    Advanced Medical and Dental Institute, University Sains Malaysia, Penang, Malaysia
    J Cutan Pathol 36:183-9. 2009
  6. pmc Relationship Between P15 Gene Mutation and Formation and Metastasis of Malignant Osteosarcoma
    Changshui Yu
    Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China mainland
    Med Sci Monit 22:656-61. 2016
  7. ncbi The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia
    S Faderl
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 89:1976-82. 2000
  8. ncbi Methylation of p15(INK4b) and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia
    Takashi Shimamoto
    First Department of Internal Medicine, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Leuk Res 29:653-9. 2005
  9. ncbi [Methylation of the genes in the 9P21 region in children with acute myeloid leukemia]
    Li Zhang
    Department of Pediatrics, Institute of Hematology, Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin 300020, China
    Zhongguo Dang Dai Er Ke Za Zhi 17:6-10. 2015
  10. doi Genetic investigation into the endophenotypic status of central corneal thickness and optic disc parameters in relation to open-angle glaucoma
    David P Dimasi
    Department of Ophthalmology, Flinders University, Adelaide, Australia
    Am J Ophthalmol 154:833-842.e2. 2012

Scientific Experts

  • Charles J Sherr
  • L Wolff
  • Xiao Fan Zhu
  • Fang Wang
  • Andriy O Yurakh
  • Shih Lan Hsu
  • Renli Qiao
  • Wei Feng
  • Tatjana Adamovic
  • Hui Yao
  • A Yalcin
  • S Eissa
  • Qingxiao Hong
  • Changshui Yu
  • Li Zhang
  • Yao Zhang
  • F Gu
  • David P Dimasi
  • Anuradha Menthena
  • Eliane F Rodrigues
  • Elodie Laharanne
  • Qian Hu
  • Ahmed I Moad
  • Manoj Bhaskaran
  • K Raj
  • Kotaro Ogawa
  • Zhihong Zhang
  • Zhensheng Liu
  • Takashi Shimamoto
  • Feijie Zhang
  • Huadan Ye
  • Yirun Li
  • Yongming Xia
  • WenBo Wang
  • L Teofili
  • Rongrong Chen
  • Linlin Tang
  • Yan Hu
  • M Tessema
  • Yuting Gao
  • Xiaoying Chen
  • Shiwei Duan
  • Annan Zhou
  • Xiao ming Liu
  • Yao Zou
  • Wen yu Yang
  • Yu Mei Chen
  • Ye Guo
  • Jia Yuan Zhang
  • Min Ruan
  • Tian feng Liu
  • Xiao Juan Chen
  • Shu chun Wang
  • Fang Liu
  • Mayi Y Arcellana-Panlilio
  • S M Dawsey
  • A M Goldstein
  • M A Tucker
  • N Wentzensen
  • H Yang
  • Y L Qiao
  • Chun Kang Chang
  • R G Ziegler
  • J Toro
  • Xiao Li
  • S S Han
  • L E Moore
  • Ling Yun Wu
  • M Garcia-Closas
  • M Yeager
  • T Ding
  • A V Brenner
  • X R Yang
  • S Berndt
  • S Bhattacharjee
  • R M Pfeiffer
  • L A Brinton
  • N Chatterjee
  • N Hu
  • L Burdette
  • C C Abnet
  • W H Chow
  • N D Freedman
  • Lu Xi Song
  • L Mirabello
  • M H Greene
  • J Lissowska
  • S J Chanock
  • P R Taylor
  • R Hayes

Detail Information

Publications42

  1. ncbi [Effect of Oviductus Ranae on Cyclin D1, CDK6 and P15 expressions in the liver tissue of aged male rats]
    Hui Yao
    College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:1044-6. 2010
    To investigate the effect of Oviductus Ranae (OR) on the expressions of CyclinD1, CDK6 and P15 in the liver of aged male rats.
  2. pmc CDKN2B, SLC19A3 and DLEC1 promoter methylation alterations in the bone marrow of patients with acute myeloid leukemia during chemotherapy
    Qingxiao Hong
    Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P R China
    Exp Ther Med 11:1901-1907. 2016
    ..patients with AML were recruited, and the promoter methylation status of cyclin-dependent kinase inhibitor 2B (CDKN2B), solute carrier family 19 member 3 (SLC19A3) and deleted in lung and esophageal cancer 1 (DLEC1)..
  3. ncbi CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine
    K Raj
    King s College London, Department of Haematological Medicine, Denmark Hill Campus, London, UK
    Leukemia 21:1937-44. 2007
    ..015). Bisulphite genomic sequencing (BGS) of the CDKN2B (p15(INK4b)) promoter showed low level, heterogeneous pretreatment methylation (mean 12...
  4. ncbi Allelic loss and promoter hypermethylation of the p15INK4b gene features in mouse radiation-induced lymphoid - but not myeloid - leukaemias
    H J Cleary
    MRC Radiation and Genome Stability Unit, Chilton, Didcot, Oxford OX11 0RD, UK
    Leukemia 13:2049-52. 1999
    ..Thus, allelic loss and promoter hypermethylation of the p15INK4b gene is particular to radiation-induced lymphoid leukaemias and is independent of p16INK4a and p19ARF gene promoter/exon 1 hypermethylation...
  5. doi Immunohistochemical determination of the P15 protein expression in cutaneous squamous cell carcinoma
    Ahmed I Moad
    Advanced Medical and Dental Institute, University Sains Malaysia, Penang, Malaysia
    J Cutan Pathol 36:183-9. 2009
    The tumor suppressor gene p15(INK4b) is a cyclin-dependent kinase inhibitor, in which its inactivation has been determined in primary tumors and in several tumor-derived cell lines...
  6. pmc Relationship Between P15 Gene Mutation and Formation and Metastasis of Malignant Osteosarcoma
    Changshui Yu
    Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China mainland
    Med Sci Monit 22:656-61. 2016
    ..The abnormal expression of P15 gene directly participates in the invasion of various cancers...
  7. ncbi The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia
    S Faderl
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 89:1976-82. 2000
    The p16(INK4a) locus encodes two distinct proteins, p16(INK4a) and p14(ARF). Although p16(INK4a) and p15(INK4b) are involved in the phosphorylation of the retinoblastoma (Rb) protein, p14(ARF) interacts with the MDM-2 oncoprotein ..
  8. ncbi Methylation of p15(INK4b) and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia
    Takashi Shimamoto
    First Department of Internal Medicine, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Leuk Res 29:653-9. 2005
    ..The tumor suppressor gene p15(INK4b) is important component of cell cycles, whereas E-cadherin gene is often termed a metastasis suppressor gene...
  9. ncbi [Methylation of the genes in the 9P21 region in children with acute myeloid leukemia]
    Li Zhang
    Department of Pediatrics, Institute of Hematology, Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin 300020, China
    Zhongguo Dang Dai Er Ke Za Zhi 17:6-10. 2015
    ..the methylation rate of cyclin-dependent kinase inhibitor 2A (CDKN2A) and cyclin-dependent kinase inhibitor 2B (CDKN2B) in the 9P21 region in children with acute myeloid leukemia (AML) and the association of gene methylation with ..
  10. doi Genetic investigation into the endophenotypic status of central corneal thickness and optic disc parameters in relation to open-angle glaucoma
    David P Dimasi
    Department of Ophthalmology, Flinders University, Adelaide, Australia
    Am J Ophthalmol 154:833-842.e2. 2012
    ..To ascertain if single nucleotide polymorphisms (SNPs) involved in the determination of central corneal thickness, optic disc area, and vertical cup-to-disc ratio (VCDR) also are associated with open-angle glaucoma (OAG)...
  11. ncbi Trans-differentiation of alveolar epithelial type II cells to type I cells involves autocrine signaling by transforming growth factor beta 1 through the Smad pathway
    Manoj Bhaskaran
    Department of Physiological Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    J Biol Chem 282:3968-76. 2007
    ..The expression of TGF beta1, Smad2, and Samd3 and their phosphorylated protein forms, and cell cycle inhibitors, p15(Ink4b) and p21(Cip1), was lower during the proliferative phase but higher during the differentiation phase...
  12. doi Promoter methylation of P15(INK4B) gene is possibly associated with parvovirus B19 infection in adult acute leukemias
    A Yalcin
    Department of Hematology, Faculty of Medicine, University of Mersin, Mersin, Turkey
    Int J Lab Hematol 31:407-19. 2009
    In this study, we examined the P15(INK4B) gene promoter methylation in patients with myelodysplastic syndrome and acute leukemia and its possible relationship with parvovirus B19 and Epstein-Barr virus infections...
  13. doi CDKN2A-CDKN2B deletion defines an aggressive subset of cutaneous T-cell lymphoma
    Elodie Laharanne
    EA 2406 Histology and Molecular Pathology, University of Bordeaux, Bordeaux, France
    Mod Pathol 23:547-58. 2010
    Inactivation of the CDKN2A-CDKN2B locus has been reported in the most frequent subtypes of cutaneous T-cell lymphomas (CTCLs), mycosis fungoides, S├ęzary syndrome (SS) and CD30+ cutaneous anaplastic large cell lymphoma...
  14. doi Epigenetic alterations of p15(INK4B) and p16(INK4A) genes in pediatric primary myelodysplastic syndrome
    Eliane F Rodrigues
    Bone Marrow Transplant Center, National Cancer Institute INCA, Rio de Janeiro, Brazil
    Leuk Lymphoma 51:1887-94. 2010
    We studied the methylation status of the p15(INK4B) and p16(INK4A) genes in 47 pediatric patients with primary MDS, its correlation with subtype, and the role of p15(INK4B) and p16(INK4A) in the evolution of MDS toward AML...
  15. ncbi Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice
    Linda Wolff
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Oncogene 22:9265-74. 2003
    The Ink4b gene (Cdkn2b) encodes p15(Ink4b), a cyclin-dependent kinase inhibitor. It has been implicated in playing a role in the development of acute myeloid leukemia (AML) in man, since it is hypermethylated with high frequency...
  16. ncbi Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis
    L Teofili
    Department of Hematology, Catholic University Rome, Italy
    Leukemia 17:919-24. 2003
    We evaluated the methylation status of p15 gene in a series of 65 patients with newly diagnosed acute promyelocytic leukemia (APL) receiving homogeneous treatment...
  17. ncbi Aberrant methylation and impaired expression of the p15(INK4b) cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML)
    M Tessema
    1Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Street 1, Hannover, Germany
    Leukemia 17:910-8. 2003
    The important cell cycle regulatory gene p15(INK4b) has been shown to be inactivated in acute myeloid leukemia and myelodysplastic syndrome...
  18. doi [p15(INK4B) methylation on prognosis and response to decitabine in patients with MDS]
    Yao Zhang
    Department of Hematology, The Sixth People s Hospital, Shanghai Jiaotong University, Shanghai, China
    Zhonghua Xue Ye Xue Za Zhi 34:237-41. 2013
    To detect p15(INK4B) methylation levels and the kinetics of the methylation status before and after decitabine to explore its influences on prognosis and response to decitabine in myelodysplastic syndromes (MDS) patients.
  19. doi p15(INK4b) regulates cell cycle signaling in hippocampal astrocytes of aged rats
    Fang Wang
    Department of Neurology, The Central Hospital of Wuhan, 26 Shengli street, Wuhan, 430014, China
    Aging Clin Exp Res 28:813-21. 2016
    Cyclin-dependent kinase inhibitor p15(INK4b) is thought to be an important player in regulating astrocytic cell cycle. However, little is known with regard to the expression of p15(INK4b) and its function in hippocampal astrocytes...
  20. ncbi Decreased proliferation and cell cycle arrest in neoplastic rat pituitary cells is associated with transforming growth factor-beta1-induced expression of p15/INK4B
    S J Frost
    Centre for Cell and Molecular Medicine, School of Postgraduate Medicine, Keele University, North Staffordshire Hospital, Stoke on Trent, ST4 7QB, UK
    Mol Cell Endocrinol 176:29-37. 2001
    ..Among other TGF-beta responsive cell cycle regulators p15(Ink4b) has been shown to have anti-proliferative effects associated with cell cycle arrest in other cell types...
  21. ncbi The Pezcoller lecture: cancer cell cycles revisited
    C J Sherr
    Howard Hughes Medical Institute and Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 60:3689-95. 2000
    ..Lesions in the p16--cyclin D-CDK4--Rb and ARF--Mdm2--p53 pathways occur so frequently in cancer, regardless of patient age or tumor type, that they appear to be part of the life history of most, if not all, cancer cells...
  22. ncbi Expression and regulation of G1 cell-cycle inhibitors (p16INK4A, p15INK4B, p18INK4C, p19INK4D) in human acute myeloid leukemia and normal myeloid cells
    J Schwaller
    Laboratory for Clinical and Experimental Research, University of Berne, Switzerland
    Leukemia 11:54-63. 1997
    ..Disparate expression of G1-specific cell cycle inhibitors indicates complex and divergent roles of particular CKIs during normal and leukemic myeloid hematopoiesis...
  23. ncbi High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats
    T Tanaka
    Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Japan
    Oncogene 18:3793-7. 1999
    ..Our data suggest that inactivation of p15 and p16 genes could be one of the major pathways responsible for oxystress-induced carcinogenesis.
  24. ncbi Molecular and immunohistochemical analysis of the prognostic value of cell-cycle regulators in urothelial neoplasms of the bladder
    Andriy O Yurakh
    Institute of Urology, Academy of Medical Science of Ukraine, Kyiv, Ukraine
    Eur Urol 50:506-15; discussion 515. 2006
    ..To evaluate the prognostic and predictive value of molecular and immunohistochemical markers related to cell-cycle control in terms of recurrence, progression, and survival in urothelial neoplasms of the bladder (UNB)...
  25. pmc Common genetic variants in the 9p21 region and their associations with multiple tumours
    F Gu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    Br J Cancer 108:1378-86. 2013
    ..The chromosome 9p21.3 region has been implicated in the pathogenesis of multiple cancers...
  26. ncbi Selective loss of resistant alleles at p15INK4B and p16INK4A genes in chemically-induced rat tongue cancers
    Kotaro Ogawa
    Department of Oral Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Oral Oncol 42:710-7. 2006
    ..Accumulation of loss of heterozygosity and methylation of the promoter regions in the tumour suppressor genes in advanced tumours suggests that they may play a role in tongue cancer progression...
  27. ncbi A potential role for p15(Ink4b) and p57(Kip2) in liver development
    M M Awad
    Department of Pediatrics, Rhode Island Hospital and Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    FEBS Lett 483:160-4. 2000
    ..for these changes, we examined the ontogeny of expression for the known cyclin-dependent kinase inhibitors (CKIs), p15(Ink4b), p16(Ink4a), p18(Ink4c), p19(Ink4d), p21(Cip1), p27(Kip1) and p57(Kip2)...
  28. ncbi Maternal choline availability alters the localization of p15Ink4B and p27Kip1 cyclin-dependent kinase inhibitors in the developing fetal rat brain hippocampus
    C D Albright
    Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7400, USA
    Dev Neurosci 23:100-6. 2001
    ..These results link maternal dietary choline availability to CDKI protein immunoreactivity and commitment to differentiation during fetal hippocampal development...
  29. ncbi Transforming growth factor-beta antagonizes alveolar type II cell proliferation induced by keratinocyte growth factor
    Feijie Zhang
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 31:679-86. 2004
    ..Cyclin D1, cdk2, and cdc25A protein levels were increased, and p15(Ink4b) and p27(Kip1) protein levels were decreased...
  30. ncbi Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors
    D F Knapek
    University of Texas M D Anderson Cancer Center, Smithville 78957, USA
    Cancer Res 55:1607-12. 1995
    ....
  31. ncbi Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules
    S L Hsu
    Department of Education and Research, Taichung Veterans General Hospital, No 160, Section 3, Chung Gang Road, 407, Taichung, Taiwan
    Eur J Pharmacol 425:165-71. 2001
    ..of cyclin D2, cyclin A, cyclin-dependent kinase 1 (Cdk1) and cyclin-dependent kinase 2 (Cdk2), and up-regulation of p15(Ink4B), p21(CIP1/Waf1), p53 and cyclin E...
  32. pmc p15(INK4b) in bladder carcinomas: decreased expression in superficial tumours
    M A Le Frere-Belda
    Service d Anatomie et de Cytologie Pathologiques, Centre Hospitalier Universitaire Henri Mondor, 94010 Creteil Cedex, France
    Br J Cancer 85:1515-21. 2001
    The p15 gene which encodes a cyclin-dependent kinase inhibitor, is located in the 9p21 chromosomal region that is frequently deleted in human bladder transitional cell carcinomas (TCCs)...
  33. ncbi Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors
    Mayi Y Arcellana-Panlilio
    Department of Oncology, University of Calgary, Calgary, Canada
    Genes Chromosomes Cancer 35:176-81. 2002
    ..These data support a role for the INK4 family of CDK inhibitors in the biology of GCTs...
  34. ncbi Identification of three genes of known function expressed by alveolar epithelial type I cells
    Renli Qiao
    Division of Pulmonary and Critical Care Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Respir Cell Mol Biol 29:98-105. 2003
    ..Furthermore, expression of these gene products in AT1-like cells, in freshly isolated AT1 cells, and AT1 cells in whole lung indicates that AT1-like cells reflect many of the properties of AT1 cells in situ...
  35. pmc Activin A, p15INK4b signaling, and cell competition promote stem/progenitor cell repopulation of livers in aging rats
    Anuradha Menthena
    Marion Bessin Liver Research Center, Division of Gastroenterology and Liver Diseases, Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Gastroenterology 140:1009-20. 2011
    ..Highly proliferative fetal liver stem/progenitor cells (FLSPCs) repopulate livers of normal recipients by cell competition. We investigated the mechanisms by which FLSPCs repopulate livers of older compared with younger rats...
  36. ncbi Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression
    Zhihong Zhang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 19:1339-43. 2006
    ..p14(ARF), p15(INK4b), and p16(INK4a), which are known to regulate G1 cell cycle arrest, and the tumor necrosis factor receptor ..
  37. ncbi Cell cycle regulators in bladder cancer: relationship to schistosomiasis
    Sanaa Eissa
    Oncology Diagnostic Unit, Medical Biochemistry Department, Ain Shams Faculty of Medicine, Cairo, Egypt
    IUBMB Life 56:557-64. 2004
    ..P16 (INK4A) and p15 (INK4B) are thought to act as tumor suppressors, since their inactivation and/or deletion are observable in various ..
  38. doi Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma
    Qian Hu
    Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Lab Invest 90:360-73. 2010
    ..These results not only show two distinct molecular pathways for iron-induced peritoneal mesothelioma, but also support the hypothesis that oxidative stress by iron overload is a major cause of CDKN2A/2B homozygous deletion...
  39. ncbi Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:4968-76. 2005
    ..The purpose of this research was to compare methylation status and mRNA expression of p15INK4b and p16INK4a in serous epithelial ovarian cancer tissues and normal ovarian tissues...
  40. doi Rearrangement and allelic imbalance on chromosome 5 leads to homozygous deletions in the CDKN2A/2B tumor suppressor gene region in rat endometrial cancer
    Tatjana Adamovic
    Human and Molecular Genetics Center, Medical College of Wisconsin, HRC 5th Floor, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    Cancer Genet Cytogenet 184:9-21. 2008
    ..reaction analysis was performed with 22 genes and markers and homozygous deletions of the CDKN2A exon 1beta and CDKN2B genes were detected in 13 EACs (62%) and of CDKN2A exon 1alpha in 12 EACs (57%) Third, the occurrence of allelic ..
  41. ncbi Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2)
    O Hino
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Mol Carcinog 14:23-7. 1995
    ..Microsatellite instability was not observed in 26 Eker rat tumors...
  42. ncbi Senescence and apoptosis in carcinogenesis of cervical squamous carcinoma
    Wei Feng
    Department of Pathology, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Mod Pathol 20:961-6. 2007
    ..Many cell cycle regulators, such as p14(ARF), p15(INK4b) and p16(INK4a), are important in G1 cell cycle arrest and oncogene-induced senescence...