Cdkn2a

Summary

Gene Symbol: Cdkn2a
Description: cyclin-dependent kinase inhibitor 2A
Alias: Arf, INK4A, MTS1, p16, p16Cdkn2a, p19ARF, cyclin-dependent kinase inhibitor 2A, CDK4I, Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4), alternative reading frame, cdkn2a, cell cycle inhibitor, cell cycle regulator, cyclin-dependent kinase 4 inhibitor A, cyclin-dependent kinase inhibitor 2a p16Ink4a, cyclin-dependent kinase inhibitor 2a p19Arf, p16-INK4, p16-INK4a
Species: rat

Top Publications

  1. pmc Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation
    G P Nielsen
    Molecular Neuro Oncology Laboratory and the James Homer Wright Pathology Laboratories, Department of Pathology and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Pathol 155:1879-84. 1999
  2. ncbi [Loss of heterozygosity in the 9p21 region as an inactivation mechanism of the p16 suppressor gene]
    M L Maestro de las Casas
    Servicio de Analisis Clinicos, Hospital Universitario San Carlos, Madrid
    Arch Esp Urol 53:603-9. 2000
  3. ncbi Mts1 protein expression in the central nervous system after injury
    Elena N Kozlova
    Department of Neuroscience, Neuroanatomy, Biomedical Center, Uppsala University, Sweden
    Glia 37:337-48. 2002
  4. ncbi p14ARF and p16INK4A, two products of the same gene, are differently expressed in cervical intraepithelial neoplasia
    Johan Bulten
    Department of Pathology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Gynecol Oncol 101:487-94. 2006
  5. ncbi [Promotor hypermethylation of E-cadherin, p16 and estrogen receptor in prostate carcinoma]
    Qing Yao
    Department of Pathology, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, 210009, China
    Zhonghua Nan Ke Xue 12:28-31. 2006
  6. doi Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene
    Tetyana V Bagnyukova
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Carcinogenesis 29:638-46. 2008
  7. ncbi p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine
    Hua Bai
    Department of Cancer Etiology, Peking University Health Science Center and Beijing Institute for Cancer Research, Da Hong Luo Chang Street, Western District, Beijing 100034, China
    Mutat Res 535:73-8. 2003
  8. pmc Ink4a/Arf expression is a biomarker of aging
    Janakiraman Krishnamurthy
    Department of Medicine, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27599 7295, USA
    J Clin Invest 114:1299-307. 2004
  9. ncbi p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice
    J A Shank-Calvo
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, 01650, USA
    Oncogene 25:3023-31. 2006
  10. pmc p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck
    Yang Zhang
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 117:1227-35. 2011

Research Grants

Scientific Experts

Detail Information

Publications98

  1. pmc Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation
    G P Nielsen
    Molecular Neuro Oncology Laboratory and the James Homer Wright Pathology Laboratories, Department of Pathology and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Pathol 155:1879-84. 1999
    ..We examined the CDKN2A/p16 gene and p16 protein in NFs and MPNSTs from patients with NF1...
  2. ncbi [Loss of heterozygosity in the 9p21 region as an inactivation mechanism of the p16 suppressor gene]
    M L Maestro de las Casas
    Servicio de Analisis Clinicos, Hospital Universitario San Carlos, Madrid
    Arch Esp Urol 53:603-9. 2000
    ..To determine the loss of heterozygosity (LOH) on 9p21 (locus D9S1747) in patients with renal carcinoma by analysis of microsatellite polymorphisms...
  3. ncbi Mts1 protein expression in the central nervous system after injury
    Elena N Kozlova
    Department of Neuroscience, Neuroanatomy, Biomedical Center, Uppsala University, Sweden
    Glia 37:337-48. 2002
    We recently showed that Mts1 is expressed in white matter astrocytes in the rat brain and spinal cord from the first postnatal day. Its expression level declined in the adult CNS, but its topographical localization was maintained...
  4. ncbi p14ARF and p16INK4A, two products of the same gene, are differently expressed in cervical intraepithelial neoplasia
    Johan Bulten
    Department of Pathology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Gynecol Oncol 101:487-94. 2006
    ..Both proteins are encoded by the same INK4A/ARF gene on chromosome 9p21...
  5. ncbi [Promotor hypermethylation of E-cadherin, p16 and estrogen receptor in prostate carcinoma]
    Qing Yao
    Department of Pathology, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, 210009, China
    Zhonghua Nan Ke Xue 12:28-31. 2006
    To investigate promotor hypermethylation of the CpG islands of E-Cadherin, p16 and estrogen receptor (ER) in prostate carcinoma and explore whether such methylation might play a role in the tumorigenesis and malignant progression of ..
  6. doi Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene
    Tetyana V Bagnyukova
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Carcinogenesis 29:638-46. 2008
    ..nucleotide element-1-associated histone H4 lysine 20 trimethylation, as well as hypermethylation of the p16(INK4A) gene. These epigenetic changes were not observed in the livers of female rats or the kidneys of both sexes...
  7. ncbi p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine
    Hua Bai
    Department of Cancer Etiology, Peking University Health Science Center and Beijing Institute for Cancer Research, Da Hong Luo Chang Street, Western District, Beijing 100034, China
    Mutat Res 535:73-8. 2003
    Inactivation of the tumor suppressor gene, p16 by CpG hypermethylation is a common event in various tumors including gastric carcinoma...
  8. pmc Ink4a/Arf expression is a biomarker of aging
    Janakiraman Krishnamurthy
    Department of Medicine, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27599 7295, USA
    J Clin Invest 114:1299-307. 2004
    The Ink4a/Arf locus encodes 2 tumor suppressor molecules, p16INK4a and Arf, which are principal mediators of cellular senescence...
  9. ncbi p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice
    J A Shank-Calvo
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, 01650, USA
    Oncogene 25:3023-31. 2006
    Analysis of the INK4A/ARF locus in human T-ALL patients revealed frequent deletions in exon 2, the exon common to both p16(INK4A) and p14(ARF)...
  10. pmc p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck
    Yang Zhang
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 117:1227-35. 2011
    p14(ARF) , an alternate reading frame (ARF) product of the cyclin-dependent kinase inhibitor 2A locus, plays a critical role in crosstalk between the tumor protein 53 (p53) and retinoblastoma (Rb) pathways and in cellular anticancer ..
  11. pmc Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model
    Karuppiah Kannan
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:1221-5. 2003
    ..Moreover, UV-induced melanomas showed a strict reciprocal relationship between cdk6 amplification and p16(INK4a) loss, which is consistent with the actions of UV along the Rb pathway...
  12. doi Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue
    Nicolai Treiber
    Department of Dermatology and Allergic Diseases, University of Ulm, Maienweg 12, Ulm, Germany
    Aging Cell 10:239-54. 2011
    ..Increase in p16(INK4a) , a robust in vivo marker for fibroblast aging, may contribute to the observed phenotype...
  13. ncbi Different prognostic values of p15(INK4b) and p16(INK4a) gene methylations in multiple myeloma
    Gaelle Guillerm
    Haematologica 88:476-8. 2003
  14. doi Epigenetic alterations of p15(INK4B) and p16(INK4A) genes in pediatric primary myelodysplastic syndrome
    Eliane F Rodrigues
    Bone Marrow Transplant Center, National Cancer Institute INCA, Rio de Janeiro, Brazil
    Leuk Lymphoma 51:1887-94. 2010
    We studied the methylation status of the p15(INK4B) and p16(INK4A) genes in 47 pediatric patients with primary MDS, its correlation with subtype, and the role of p15(INK4B) and p16(INK4A) in the evolution of MDS toward AML...
  15. ncbi Population-based prevalence of CDKN2A mutations in Utah melanoma families
    Mark J Eliason
    Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    J Invest Dermatol 126:660-6. 2006
    Cyclin-dependent kinase inhibitor 2A (CDKN2A or p16) is the major melanoma predisposition gene...
  16. pmc Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children
    Heng Xu
    1 Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA 2 Department of Laboratory Medicine, National Key Laboratory of Biotherapy Collaborative Innovation Center of Biotherapy, and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
    Nat Commun 6:7553. 2015
    ..Here we show a missense variant in CDKN2A associated with the development of ALL at genome-wide significance (rs3731249, P=9.4 × 10(-23), odds ratio=2.23)...
  17. doi p16(CDKN2A) expression during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide
    Yun Hong
    Department of Oral Medicine, Guanghua School of Stomatology, Sun Yat Sen University, 56 Lingyuanxi Road, Guangzhou, Guangdong 510060, PR China
    Oral Oncol 45:640-4. 2009
    p16(CDKN2A) is one of the most important tumor-suppressor genes and has been investigated widely in recent years for its role in oral carcinogenesis, but few have explored the relationship between its RNA and protein, especially in ..
  18. ncbi Expression of the cell cycle regulators p14(ARF) and p16(INK4a) in chronic myeloid leukemia
    Marie Cividin
    Laboratoire d Hematologie, CHU de Poitiers, France
    Leuk Res 30:1273-8. 2006
    Expression of p14(ARF) and p16(INK4a) tumor suppressor genes was investigated in 109 patients with chronic myeloid leukemia (CML)...
  19. pmc Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia
    Richard T Williams
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 103:6688-93. 2006
    ..of BCR-ABL-positive acute lymphoblastic leukemias (ALLs), many of which sustain deletions of the INK4A-ARF (CDKN2A) tumor suppressor locus...
  20. doi Methylation of the p16INK4A promoter is associated with malignant behavior in abdominal extra-adrenal paragangliomas but not pheochromocytomas
    N B Kiss
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital Solna, CMM L8 01 SE 171 76 Stockholm, Sweden
    Endocr Relat Cancer 15:609-21. 2008
    ..Studies in animal models have shown that inactivation of the products of the cyclin dependent kinase inhibitor 2A (CDKN2A) gene locus, p16INK4A and p14ARF, promotes the development of pheochromocytoma, especially ..
  21. ncbi Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B
    J G Herman
    Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 56:722-7. 1996
    ..prostate, and colon cancer, inactivation of p15INK4B occurs only rarely and only with concomitant inactivation of p16. Aberrant methylation of p15INK4B is associated with transcriptional loss of this gene...
  22. pmc Independent prognostic significance of cell cycle regulator proteins p16(INK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: a translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaek
    S Kommoss
    Dr Horst Schmidt Klinik HSK Wiesbaden, Department of Gynecology and Gynecologic Oncology, Ludwig Erhard Str 100, Wiesbaden 65199, Germany
    Br J Cancer 96:306-13. 2007
    The purpose of the study is to test the hypothesis that expression of cell cycle regulatory proteins p16(INK4a) and pRb is significantly associated with prognosis in ovarian carcinomas...
  23. doi Direct promoter induction of p19Arf by Pit-1 explains the dependence receptor RET/Pit-1/p53-induced apoptosis in the pituitary somatotroph cells
    E Diaz-Rodriguez
    IDIS Neoplasia and Endocrine Differentiation, Department of Physiology, CIMUS, School of Medicine, University of Santiago de Compostela USC, Santiago de Compostela, Spain
    Oncogene 31:2824-35. 2012
    ..We have found a Pit-1 DNA-binding element within the ARF promoter. Pit-1 directly regulates the CDKN2A locus and binds to the p19Arft promoter inducing p19Arf gene expression...
  24. doi Duhuo Jisheng Decoction promotes chondrocyte proliferation through accelerated G1/S transition in osteoarthritis
    Guangwen Wu
    Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P R China
    Int J Mol Med 32:1001-10. 2013
    ..TEM) and the mRNA and protein expression levels of cyclin D1, CDK4, CDK6, retinoblastoma protein (Rb) and p16 were measured by RT‑PCR and immunohistochemistry, respectively...
  25. doi The p16(INK4A)/pRb pathway and telomerase activity define a subgroup of Ph+ adult Acute Lymphoblastic Leukemia associated with inferior outcome
    Wei W Chien
    Claude Bernard Lyon 1 University, CNRS UMR 5239 ENS HCL, Lyon Sud Medicine Faculty, Lyon, France
    Leuk Res 39:453-61. 2015
    ..The p16(INK4A)/CDK4-6/pRb pathway and telomerase activity, which are implicated in cell activation and aging, were analyzed to ..
  26. ncbi Lack of ETV6 (TEL) gene rearrangements or p16INK4A/p15INK4B homozygous gene deletions in infant acute lymphoblastic leukemia
    K W Maloney
    Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
    Leukemia 11:979-83. 1997
    ..described molecular abnormalities in childhood ALL are ETV6 gene rearrangements and homozygous deletions of p16(INK4A) and/or p15(INK4B)...
  27. doi Promoter hypermethylation of tumour suppressor genes (p14/ARF and p16/INK4a): case-control study in North Indian population
    Marjan Askari
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Biol Rep 40:4921-8. 2013
    ..study, it has been tried to determine the methylation status of two tumour suppressor genes p14/ARF and p16/INK4a in 150 breast cancer patients as well as 150 controls by using MSP-PCR...
  28. ncbi The Pezcoller lecture: cancer cell cycles revisited
    C J Sherr
    Howard Hughes Medical Institute and Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 60:3689-95. 2000
    ..The ARF tumor suppressor, encoded by an alternative reading frame of the INK4a-ARF locus, senses "mitogenic current" flowing through the Rb pathway and is induced by ..
  29. ncbi High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families
    A Borg
    Department of Oncology, University Hospital, Lund, Sweden
    J Natl Cancer Inst 92:1260-6. 2000
    Inherited mutations in the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) protein, and in the cyclin-dependent kinase 4 (CDK4) gene confer susceptibility to cutaneous malignant melanoma...
  30. pmc Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia
    Emmanuel J Volanakis
    Division of Pediatric Hematology Oncology, Vanderbilt University, Nashville, TN, USA
    Exp Hematol 41:377-86. 2013
    Activating mutations of NOTCH1 and deletion of the INK4A-ARF (CDKN2A) tumor suppressor locus are two of the most frequent genetic alterations in T cell acute lymphoblastic leukemia (T-ALL)...
  31. pmc Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility
    S L Zhang
    Laboratory of Genetics, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 21:310-8. 2001
    ..7-centimorgan (cM) chromosomal region that included Cdkn2a, which encodes p16(INK4a) and p19(ARF), and the coding sequences for the BALB/c p16(INK4a) and p19(ARF) alleles ..
  32. ncbi Comparisons of tumor suppressor p53, p21, and p16 gene therapy effects on glioblastoma tumorigenicity in situ
    T J Wang
    Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China
    Biochem Biophys Res Commun 287:173-80. 2001
    ..this study, the functional expression and efficacy in tumor suppression of 3 tumor suppressor genes (p53, p21, and p16) were tested and compared in a rat GBM cell line (RT-2) after retrovirus mediated gene delivery in vitro and in ..
  33. pmc Histone deacetylase 3 (HDAC3) participates in the transcriptional repression of the p16 (INK4a) gene in mammary gland of the female rat offspring exposed to an early-life high-fat diet
    Shasha Zheng
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Epigenetics 7:183-90. 2012
    ..The purpose of this study was to examine the effect of a maternal high-fat diet on the regulation of p16 (INK4a) gene expression in the mammary gland of rat offspring...
  34. ncbi Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death
    J Katchanov
    Experimental Neurology, Department of Neurology, Institute of Pharmacology and Toxicology, Charite, Humboldt University of Berlin, D 10098 Berlin, Germany
    J Neurosci 21:5045-53. 2001
    ..We demonstrate that loss of endogenous cyclin-dependent kinase (Cdk) inhibitor p16(INK4a) is an early and reliable indicator of delayed neuronal death in striatal neurons after mild cerebral ischemia in ..
  35. ncbi Different p16INK4a and p14ARF expression patterns in acute myeloid leukaemia and normal blood leukocytes
    M P Tschan
    Department of Clinical Research, University and Inselspital, Berne, Switzerland
    Leuk Lymphoma 42:1077-87. 2001
    ..The p14ARF, an alternative reading frame protein encoded from the same INK4a-ARF locus, is a potent tumour suppressor functionally linked to p53...
  36. doi Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model
    Xiyuan Zhang
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, 61801, USA
    Am J Physiol Gastrointest Liver Physiol 302:G558-64. 2012
    ..Gene analysis demonstrated a significant increase of both the amount and the transcription rates of p16(INK4a) and p21(Cip1) mRNA in OP rats...
  37. pmc Astrocyte senescence as a component of Alzheimer's disease
    Rekha Bhat
    Department of Pathology and Laboratory Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e45069. 2012
    ..tissue from aged individuals and patients with AD was examined for the presence of senescent astrocytes using p16(INK4a) and matrix metalloproteinase-1 (MMP-1) expression as markers of senescence...
  38. doi Change of p16(INK4a) and PCNA protein expression in myocardium after injection of hIGF-1 gene modified skeletal myoblasts into post-infarction rats
    Yanzhang Gao
    The Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, the Laboratory of Target Biology Therapy in Hubei Province, Wuhan 430022, China
    J Huazhong Univ Sci Technolog Med Sci 28:396-400. 2008
    This study examined the change of p16(INK4a) and PCNA protein expression in myocardium after injection of hIGF-1 gene modified skeletal myoblasts into post-infarction rats...
  39. doi Grape juice concentrate modulates p16 expression in high fat diet-induced liver steatosis in Wistar rats
    Andressa Orlandeli Ferreira
    Department of Biosciencies, Federal University of Sao Paulo, Santos, Brazil
    Toxicol Mech Methods 22:218-24. 2012
    ..The effects of grape juice concentrate treatment on histopathological changes, and immunohistochemistry for p53, p16 and p21 were evaluated.
  40. doi Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine
    Wen Bin Liu
    Department of Hygienic Toxicology, Preventive Medical College, Third Military Medical University, Key Laboratory of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, Chongqing 400038, PR China
    Toxicol Lett 189:5-13. 2009
    ..Remarkably, epigenetic alterations in p16 (CDKN2A), but not in p15 (CDKN2B), were observed, and these correlated with the presence of pathologic lung lesions and ..
  41. ncbi Selective loss of resistant alleles at p15INK4B and p16INK4A genes in chemically-induced rat tongue cancers
    Kotaro Ogawa
    Department of Oral Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Oral Oncol 42:710-7. 2006
    ..Accumulation of loss of heterozygosity and methylation of the promoter regions in the tumour suppressor genes in advanced tumours suggests that they may play a role in tongue cancer progression...
  42. doi H3K9me-enhanced DNA hypermethylation of the p16INK4a gene: an epigenetic signature for spontaneous transformation of rat mesenchymal stem cells
    Yong Zheng
    Department of Anatomy and Embryology, Center for Medical Research, Wuhan University School of Medicine, Wuhan, People s Republic of China
    Stem Cells Dev 22:256-67. 2013
    ..stem cells (MSCs), changes in senescence-associated molecules, particularly the epigenetic modification of the p16(INK4a) gene, including histone H3 lysine 27/9 methylation (H3K27/9me) and DNA methylation, were investigated in cultured ..
  43. ncbi Expression of cell cycle regulator p16 is not affected by diabetes during oral oncogenesis
    Eleftherios Vairaktaris
    Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Athens 11521, Greece
    In Vivo 21:745-50. 2007
    The tumor suppressor protein p16 plays a vital role in the regulation of the cell cycle...
  44. ncbi Reduced expression of INK4a/ARF genes in stem-like sphere cells from rat sarcomas
    Hiromasa Fujii
    Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Biochem Biophys Res Commun 362:773-8. 2007
    ..Interestingly, spheres from both sarcomas remarkably decreased the expression of INK4a/ARF locus genes, p16(INK4a) and p19(ARF), which could be related to the resistance against cell senescence and ..
  45. ncbi Frequent mutation of p16(CDKN2A) exon 1 during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide
    Yun Hong
    Department of Oral Medicine, Guanghua School of Stomatology, Sun Yat Sen University, Guangzhou, China
    Mol Carcinog 46:85-90. 2007
    ..Twenty mutations, including a missense mutation of the start codon resulting in alternative reading frame of p16(CDKN2A) exon 1, were also identified...
  46. ncbi Epigenetic changes in the rat livers induced by pyrazinamide treatment
    V M Kovalenko
    Institute of Pharmacology and Toxicology of the Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
    Toxicol Appl Pharmacol 225:293-9. 2007
    ..LINE-1), and aberrant promoter hypermethylation of placental form glutathione-S-transferase (GSTP) and p16(INK4A) genes in livers of pyrazinamide-treated rats, while serum levels of bilirubin and activity of aminotransferases ..
  47. pmc Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss
    Michael T Debies
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Invest 118:51-63. 2008
    ..Relapses occurring in the context of null Ink4a/Arf alleles (disrupting both the p16 Ink4a and p19 Arf tumor suppressors) arose quickly and rarely reactivated the Wnt pathway...
  48. ncbi Differential Immunoreactivity of p16 in leiomyosarcomas and leiomyoma variants
    Brian R Gannon
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Int J Gynecol Pathol 27:68-73. 2008
    ..include insulinlike growth factor 1, h-caldesmon, cytokeratin 18, and the cyclin-dependent kinase 4 inhibitor, p16. To determine whether the immunohistochemical expression of these proteins could aid in the diagnosis of LMS and LM ..
  49. ncbi P16(INK4a) immunocytochemistry in liquid-based cytology samples in equivocal Pap smears: added value in management of women with equivocal Pap smear
    Joseph Monsonego
    Alfred Fournier Institute, Paris, France
    Acta Cytol 51:755-66. 2007
    To test whether p1l6(INK4a) immunocytochemistry (ICC) in liquid-based cytology (LBC) is useful with colposcopy in abnormal Pap smears.
  50. doi Prevalence of mucosal and cutaneous human papillomaviruses in different histologic subtypes of vulvar carcinoma
    Maurits N C de Koning
    DDL Diagnostic Laboratory, Voorburg, The Netherlands
    Mod Pathol 21:334-44. 2008
    ..The HPV 16 intratypic variation showed correlation with patients' ethnic background. P16INK4a immunostaining seems to be a sensitive and specific marker of vulvar carcinomas positive for oncogenic mucosal HPVs...
  51. ncbi The effect of phenobarbital on the methylation level of the p16 promoter region in rat liver
    Grazyna Kostka
    Department of Environmental Toxicology, National Institute of Hygiene, Chocimska 24, 00 791, Warsaw, Poland
    Toxicology 239:127-35. 2007
    ..PB) -- a non-genotoxic rodent liver carcinogen -- on the methylation level of the promoter region of the p16 suppressor gene, as well as on hepatomegaly, DNA synthesis, and DNA-methyltransferase (DNMTs) activity in the rat ..
  52. doi p16ink4 immunoreactivity is a reliable marker for urothelial carcinoma in situ
    Ming Yin
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
    Hum Pathol 39:527-35. 2008
    ..Mutations of the cell cycle regulatory gene INK4a (located at 9p21) that encodes p16(INK4) are one of the critical early events in carcinogenesis of UC...
  53. ncbi Growth inhibition and induction of apoptosis by 2-methoxyestradiol in rat osteosarcoma and malignant fibrous histiocytoma cell lines
    Hiromasa Fujii
    Department of Orthopedic Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, Japan
    In Vivo 22:21-5. 2008
    ..The activity of caspase-3 was increased at 20 h and 40 h in both cell lines. 2-ME induced p16 expression, which was possibly involved in the apoptotic process...
  54. doi Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a
    Jens H Westhoff
    Division of Pediatric Nephrology, University Children s Hospital, Heidelberg, Germany
    Hypertension 52:123-9. 2008
    ..b>Cell cycle inhibitor p16(INK4a) is the key mediator for stress and aberrant signaling induced senescence...
  55. doi Rearrangement and allelic imbalance on chromosome 5 leads to homozygous deletions in the CDKN2A/2B tumor suppressor gene region in rat endometrial cancer
    Tatjana Adamovic
    Human and Molecular Genetics Center, Medical College of Wisconsin, HRC 5th Floor, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    Cancer Genet Cytogenet 184:9-21. 2008
    ..The copy numbers of loci situated on RNO5 were found to be reduced, particularly for the CDKN2A/2B locus...
  56. pmc The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation
    Florence Gizard
    Division of Endocrinology and Molecular Medicine, University of Kentucky College of Medicine, Lexington, KY 40536 0200, USA
    Circ Res 103:1155-63. 2008
    ..activation suppresses G(1)-->S cell cycle progression by targeting the cyclin-dependent kinase inhibitor p16(INK4a) (p16)...
  57. doi No mutations found in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide
    Eliana Maria Minicucci
    Department of Dermatology and Radiotherapy, Sao Paulo State University, UNESP, Botucatu, SP, Brazil
    J Mol Histol 40:71-6. 2009
    ..The present study aimed to investigate mutations in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide (4NQO) using direct DNA-sequencing method...
  58. pmc Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model
    Yan ping Du
    School of Public Health, Sun Yat Sen University, Guangzhou 510080, PR China
    BMC Cancer 9:261. 2009
    ..of certain proto-oncogenes, such as c-myc, as well as the inactivation of certain tumor suppressors, such as p16. Betaine, as an active methyl-donor, maintains normal DNA methylation patterns...
  59. doi Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma
    Qian Hu
    Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Lab Invest 90:360-73. 2010
    ..SMs revealed massive genomic alterations after aCGH analysis, including homozygous deletion of CDKN2A/2B and amplification of ERBB2 containing region, whereas EMs showed less genomic alterations...
  60. doi DNA copy number aberrations and disruption of the p16Ink4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas
    Daisuke Iizuka
    Experimental Radiobiology for Children s Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, 263 8555, Japan
    Radiat Res 174:206-15. 2010
    ..These aberrations were not observed in seven spontaneous mammary carcinomas. The expression of p16Ink4a and p19Arf, which are located in the chromosomal region 5q32, was always up-regulated except for a carcinoma with a ..
  61. doi Methylation of RAR-β2, RASSF1A, and CDKN2A genes induced by nickel subsulfide and nickel-carcinogenesis in rats
    Jun Zhang
    Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai 200092, China
    Biomed Environ Sci 24:163-71. 2011
    To investigate the expression variation of RAR-β2, RASSF1A, and CDKN2A gene in the process of nickel-induced carcinogenesis.
  62. ncbi Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents
    Lianhui Tao
    Department of Pathology, HEB, Rm 202, Medical College of Ohio, 3055 Arlington Ave, Toledo, OH 43614 5806, USA
    Carcinogenesis 23:1447-54. 2002
    ..In colon tumors relative to the mucosa, the protein and mRNA levels of c-myc were increased, while the levels of p16 and p27 were decreased...
  63. ncbi Coexistence of copy number changes of different genes (INK4A, erbB-1, erbB-2, CMYC, CCND1 and ZNF217) in urothelial tumors
    D Toncheva
    Department of Medical Genetics, Medical Faculty Sofia, Sofia, Bulgaria
    Tumour Biol 26:88-93. 2005
    The aim of this study was to establish the frequency of combinatorial and separate copy number changes of INK4A (9p21), erbB-1 (7p11), erbB-2 (17q17-21), CMYC (8q24), CCND1 (11q13) and ZNF217 (20q13) in urothelial tumors; a tissue ..
  64. pmc A common variant of CDKN2A (p16) predisposes to breast cancer
    T Debniak
    Department of Genetics and Pathology, International Hereditary Cancer Centre, Pomeranian Medical University, Szczecin, Poland
    J Med Genet 42:763-5. 2005
    A common missense variant of the CDKN2A gene (A148T) predisposes to malignant melanoma in Poland. An association between malignant melanoma and breast cancer has been reported in several families with CDKN2A mutations,
  65. ncbi The INK4a /ARF locus: role in cell cycle control for renal cell epithelial tumor growth after the Chernobyl accident
    Alina Romanenko
    Department of Pathology, Institute of Urology, Academy of Medical Sciences of Ukraine, 9 a Yu Kotzubinsky, 04053 Kiev, Ukraine
    Virchows Arch 445:298-304. 2004
    ..The present paper describes the molecular alterations of those tumor suppressor genes located on chromosome 9p21 ( INK4a/ARF locus and p15(INK4B)) in 26 primary renal-cell epithelial tumors from patients with different degrees of ..
  66. ncbi High frequency methylation of p16INK4A gene during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
    Yuuji Nakahara
    Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine, Ehime, Japan
    Oncol Rep 12:101-6. 2004
    ..Inactivation by hypermethylation of the promoter region of p16INK4A gene was related to carcinogenesis of oral cancer...
  67. ncbi [p16 protein expression in the transplacental induced brain tumor in rat]
    Zhong yuan Zhang
    Department of Nurosurgery of Peking University First Hospital, Beijing 100034, China
    Zhonghua Wai Ke Za Zhi 42:358-61. 2004
    To study in series the p16 protein expression on the rat brain tumor induced transplacentally by ENU.
  68. ncbi Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing
    Masataka Sugimoto
    Howard Hughes Medical Institute, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Mol Cell 11:415-24. 2003
    The p19(Arf) tumor suppressor, a nucleolar protein, binds to Mdm2 to induce p53-dependent cell cycle arrest. Arf also prevents the proliferation of cells lacking Mdm2 and p53, albeit less efficiently...
  69. ncbi Cloning of the 5' upstream region of the rat p16 gene and its role in silencing
    Masanobu Abe
    Carcinogenesis Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:1100-6. 2002
    Hypermethylation of the 5' upstream region (5' region) of the human p16(CDKN2A) (p16) gene is known to cause silencing, which is involved in a wide range of human cancers...
  70. ncbi De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats
    Igor P Pogribny
    Division of Biochemical Toxicology, Federal Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Cancer Lett 187:69-75. 2002
    ..model of multistage hepatocarcinogenesis was used to evaluate progressive in vivo changes in p16 promoter methylation in both preneoplastic and tumor tissues...
  71. ncbi Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors
    Mayi Y Arcellana-Panlilio
    Department of Oncology, University of Calgary, Calgary, Canada
    Genes Chromosomes Cancer 35:176-81. 2002
    ..The status of RB1, INK4A, INK4B, INK4C, INK4D, and ARF in 13 adult and 2 juvenile ovarian GCTs was determined by reverse transcription-..
  72. ncbi p16INK4a and p14ARF methylation as a potential biomarker for human bladder cancer
    Ken Kawamoto
    Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 08520, Japan
    Biochem Biophys Res Commun 339:790-6. 2006
    ..We examined whether the methylation status of p16(INK4a) and p14(ARF), genes located upstream of the RB and p53 pathway, is a useful biomarker for the staging, clinical ..
  73. ncbi Aberrant CpG island methylation of the p16(INK4a) and estrogen receptor genes in rat lung tumors induced by particulate carcinogens
    Steven A Belinsky
    Lovelace Respiratory Research Institute, Lung Cancer Program, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
    Carcinogenesis 23:335-9. 2002
    Recent studies by our laboratory indicate that the p16(INK4a) gene is frequently methylated in lung tumors induced by genotoxic carcinogens and that the frequency for methylation of the estrogen receptor alpha (ER) gene varies as a ..
  74. pmc Specific allelic loss of p16 (INK4A) tumor suppressor gene after weeks of iron-mediated oxidative damage during rat renal carcinogenesis
    Makoto Hiroyasu
    Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Am J Pathol 160:419-24. 2002
    Oxidative tissue damage has been shown to be associated with carcinogenesis. In human cancers p16(INK4A) is one of the most frequently mutated tumor suppressor genes...
  75. ncbi Early deregulation of the the p16ink4a-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway in cell proliferation-driven esophageal tumorigenesis in zinc-deficient rats
    L Y Fong
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 60:4589-95. 2000
    ....
  76. ncbi Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors
    A Heidenreich
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Urol 159:1725-30. 1998
    b>p16 (MTS 1) and p15 (MTS 2) are negative regulators of cell cycle progression at the G1 cell cycle checkpoint and function as tumor suppressor genes (TSG)...
  77. ncbi Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma
    A Platz
    Department of Oncology, Karolinska Hospital, Stockholm, Sweden
    J Natl Cancer Inst 89:697-702. 1997
    ..The tumor suppressor genes CDKN2A and CDKN2B have been mapped to the 9p21 region, and genetic analyses have revealed the presence of germline CDKN2A ..
  78. pmc Frequent aberrant methylation of p16INK4a in primary rat lung tumors
    D S Swafford
    Inhalation Toxicology Research Institute, Albuquerque, New Mexico 87185, USA
    Mol Cell Biol 17:1366-74. 1997
    The p16INK4a (p16) tumor suppressor gene is frequently inactivated by homozygous deletion or methylation of the 5' CpG island in cell lines derived from human non-small-cell lung cancers...
  79. pmc High frequency of aberrant p16(INK4A) expression in human breast cancer
    J Geradts
    Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, USA
    Am J Pathol 149:15-20. 1996
    ..p16(INK4A) (16), inhibits phosphorylation of the retinoblastoma protein, pRB, and thus acts as a negative cell cycle regulator. It is inactivated in a wide range of human malignancies, including breast cancer...
  80. ncbi Loss of p16 in recurrent malignant mixed müllerian tumors of the uterus
    B Robinson-Bennett
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The University of Texas Medical Branch, Galveston, TX, USA
    Int J Gynecol Cancer 16:1354-7. 2006
    ..Five cases of recurrent uterine MMMT were examined by paraffin immunohistochemistry for the expression of p53, p16, P-cadherin, and Cerb-B2...
  81. ncbi Immunohistochemical expression of p16(INK4A) in normal uterine cervix, nonneoplastic epithelial lesions, and low-grade squamous intraepithelial lesions
    Gustavo R A Focchi
    Department of Pathology, Federal University of São Paulo UNIFESP E P M, Sao Paulo, Brazil
    J Low Genit Tract Dis 11:98-104. 2007
    In this study, the authors analyzed the immunoexpression of p16 in high-risk human papillomavirus DNA-negative normal and nonneoplastic cervical epithelia, in low-grade cervical intraepithelial neoplasia (CIN), high-grade CIN, and ..
  82. ncbi Promoter hypermethylation of p16INK4A, p14ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients
    Gayatri Sharma
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Life Sci 80:1873-81. 2007
    ..The aim of this study is to determine the correlation between methylation status of multiple cancer genes, p16(INK4A), p14(ARF), Cyclin D2 and Slit2 in invasive ductal carcinoma of the breast and paired serum DNA and ..
  83. ncbi p16INK4A-silencing augments DNA damage-induced apoptosis in cervical cancer cells
    W M Lau
    Division of Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore
    Oncogene 26:6050-60. 2007
    p16(INK4A) (p16) has been suggested to be an early biomarker for the detection of cervical cancer. However, its functional role in cervical cancer is not well characterized...
  84. ncbi Complex patterns of chromosome 9 alterations including the p16INK4a locus in Wilms tumours
    R Natrajan
    Paediatric Oncology, Institute of Cancer Research Royal Marsden NHS Trust, Sutton, UK
    J Clin Pathol 61:95-102. 2008
    Previous data implicating genetic and epigenetic events on chromosome 9, including the CDKN2A/2B locus, as molecular predictors of Wilms tumour relapse, have been conflicting.
  85. ncbi Homozygous deletions of the INK4a/ARF locus in renal cell cancer
    Takashi Kasahara
    Division of Molecular Oncology, Niigata University Grauate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata, Japan
    Anticancer Res 26:4299-305. 2006
    ..P14(ARF) was investigated by focusing on the homozygous deletion (HD) in the INK4a/ARF locus and hypermethylation of the p14(ARF) promoter in renal cell cancer (RCC).
  86. ncbi DNA methylation pathway alterations in an autochthonous murine model of prostate cancer
    Shannon R Morey
    Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Res 66:11659-67. 2006
    ..Surprisingly, methylation of a downstream exon of p16(INK4a) (p16) was the highest frequency hypermethylation event identified in TRAMP, where it is associated with increased ..
  87. ncbi Carcinogen exposure and epigenetic silencing in bladder cancer
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Ann N Y Acad Sci 1076:810-21. 2006
    ..human bladder cancer (n = 351), the relationship between epigenetic silencing of the tumor-suppressor genes, p16(INK4A), RASSF1A, PRSS3, and the four SFRP genes and exposure to both tobacco and arsenic in bladder cancer...
  88. ncbi Immunohistochemical expression of p16 and p53 in vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva
    Mauricio Cordoni Nogueira
    Santa Rita Cancer Center, Complexo Hospitalar Santa Casa de Porto Alegre, Porto Alegre, Brazil
    Pathol Oncol Res 12:153-7. 2006
    This study was undertaken to examine the expression of p16 and p53 in vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma (SCC) of the vulva...
  89. ncbi Expression of the cell cycle regulators p53, p21(WAF1/CIP1) and p16(INK4a) in human endometrial adenocarcinoma
    L G Buchynska
    R E Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, Kyiv, Ukraine
    Exp Oncol 28:152-5. 2006
    To study correlation links between expression level of proteins p53, p21(WAF1/CIP), p16(INK4) and proliferative potential in human endometrial adenocarcinoma (EC).
  90. ncbi High-grade ovarian serous carcinoma exhibits significantly higher p16 expression than low-grade serous carcinoma and serous borderline tumour
    C J O'Neill
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, Northern Ireland, UK
    Histopathology 50:773-9. 2007
    ..The aim of this study was to compare expression of p16 INK4A (p16) in these two tumour types...
  91. ncbi Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression
    Zhihong Zhang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 19:1339-43. 2006
    ..p14(ARF), p15(INK4b), and p16(INK4a), which are known to regulate G1 cell cycle arrest, and the tumor necrosis factor receptor superfamily member ..
  92. ncbi Methylation of p16INK4a is a non-rare event in cervical intraepithelial neoplasia
    Suki Kang
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    Diagn Mol Pathol 15:74-82. 2006
    The cell cycle inhibitor, p16INK4a may be a useful surrogate biomarker of cervical intraepithelial neoplasia (CIN); however, there is currently no consensus of p16INK4a genetic alterations throughout the multiple step process of CIN...
  93. ncbi Aberrant promoter methylation of multiple genes in malignant ovarian tumors and in ovarian tumors with low malignant potential
    Andrew Wiley
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Cancer 107:299-308. 2006
    ....
  94. ncbi The rat ARF protein is translated from two closely spaced ATG start codons and can transcriptionally activate p53 in the absence of p53 protein stabilization
    Abigail E Hunt
    UCSF Cancer Research Institute, San Francisco, California 94115, USA
    Cell Cycle 5:1324-30. 2006
    We have analyzed the transcriptional start sites of the rat ARF gene and the amino acid sequence of the rat ARF tumor suppressor protein...
  95. ncbi Immunohistochemical expression of p16(INK4a) is predictive of HR-HPV infection in cervical low-grade lesions
    Maria Benevolo
    Department of Pathology, Regina Elena Cancer Institute, Rome, Italy
    Mod Pathol 19:384-91. 2006
    The p16(INK4a) is a cyclin-dependent kinase inhibitor that decelerates the cell cycle by inactivating the cyclin-dependent kinases involved in the phosphorylation of the retinoblastoma protein (RB)...
  96. ncbi Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer
    Rosa M Pascale
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Italy
    Hepatology 42:1310-9. 2005
    ..Upregulation of p16(INK4A), Hsp90, and Cdc37 genes; an increase in Cdc37-Cdk4 complexes; and a decrease in p16(INK4A)-Cdk4 complexes ..
  97. doi Molecular analysis of the Ink4a/Rb1-Arf/Tp53 pathways in radon-induced rat lung tumors
    Kristell Bastide
    CEA, DSV, IRCM, SREIT, Laboratoire de Cancerologie Experimentale, BP6, Fontenay aux Roses Cedex F 92265, France
    Lung Cancer 63:348-53. 2009
    ..The expressions of p19Arf, Mmd2 and Mdm4 were not deregulated and only 14% of the tumors were mutated for Tp53...

Research Grants3

  1. MARKERS FOR LUNG CARCINOGENESIS IN BRONCHIAL EPITHELIUM
    Steven Belinsky; Fiscal Year: 2001
    ..f., simply markers of exposure) and help identify genetic alterations that are candidate markers of respiratory carcinogenesis. ..
  2. Gene Methylation and Therapeutic Response in Lung Cancer
    Steven Belinsky; Fiscal Year: 2005
    ..In support of these critical needs, our laboratory has identified two excellent biomarkers, the p16 tumor suppressor gene and the O6-methylguanine-DNA methyltransferase (MGMT) repair gene, whose inactivations ..
  3. TUMOR SUPPRESSOR GENE METHYLATION IN LUNG ADENOCARCINOMA
    Steven A Belinsky; Fiscal Year: 2010
    ..Specific Aim 3 will identify factors involved in establishing repressed chromatin around promoter regions for the p16 and death associated protein kinase genes...