Cdk9

Summary

Gene Symbol: Cdk9
Description: cyclin-dependent kinase 9
Alias: cyclin-dependent kinase 9, cell division protein kinase 9, cyclin-dependent kinase 9 (CDC2-related kinase)
Species: rat

Top Publications

  1. pmc Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure
    Motoaki Sano
    Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    EMBO J 23:3559-69. 2004
  2. doi Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver
    Ji Yin Zhou
    Base for Drug Clinical Trial, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, PR China
    Fitoterapia 82:184-9. 2011
  3. doi Updating the RNA polymerase CTD code: adding gene-specific layers
    Sylvain Egloff
    Universite de Toulouse, UPS, Laboratoire de Biologie Moleculaire Eucaryote, F 31000 Toulouse, France
    Trends Genet 28:333-41. 2012
  4. pmc Control of transcriptional elongation
    Hojoong Kwak
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 2703 email
    Annu Rev Genet 47:483-508. 2013
  5. ncbi Activation of MyoD-dependent transcription by cdk9/cyclin T2
    Cristiano Simone
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, Pennsylvania, PA 19122, USA
    Oncogene 21:4137-48. 2002
  6. ncbi P-TEFb is a crucial co-factor for Myc transactivation
    Barbara Gargano
    Department of Structural and Functional Biology, University of Naples Federico II, Naples, Italy
    Cell Cycle 6:2031-7. 2007
  7. pmc Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes
    Yoichi Sunagawa
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization, 1 1 Mukaihata cho, Fukakusa, Fushimi ku, Kyoto, Japan
    J Biol Chem 285:9556-68. 2010

Scientific Experts

  • Hojoong Kwak
  • Sylvain Egloff
  • Ji Yin Zhou
  • Yoichi Sunagawa
  • Barbara Gargano
  • Motoaki Sano
  • Cristiano Simone
  • Shona Murphy
  • Martin Dienstbier
  • Shi Wen Zhou
  • Hiromichi Wada
  • Tatsuya Morimoto
  • Teruhisa Kawamura
  • Akira Shimatsu
  • Shinji Kaichi
  • Tomohide Takaya
  • Koji Hasegawa
  • Masatoshi Fujita
  • Toru Kita
  • Luigi Lania
  • Barbara Majello
  • Stefano Amente
  • Toru Tanaka
  • Lloyd H Michael
  • Prathit A Kulkarni
  • Sam C Wang
  • Satoshi Sakai
  • George E Taffet
  • Keith A Youker
  • Michael D Schneider
  • Yasuo Hamamori
  • Min Xie
  • William J Craigen
  • Manabu Shirai
  • Philip M Barger
  • Fernando Scaglia
  • Pier Lorenzo Puri
  • Antonio Giordano
  • Luigi Bagella
  • Antonio De Luca
  • Cristiana Bellan
  • Bruna Pucci
  • Giulia De Falco
  • Ginevra Guanti
  • Peter Stiegler

Detail Information

Publications8

  1. pmc Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure
    Motoaki Sano
    Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    EMBO J 23:3559-69. 2004
    ..Previously, we showed that hypertrophy is accompanied by activation of cyclin T/Cdk9, which phosphorylates the C-terminal domain of the large subunit of RNA polymerase II, stimulating transcription ..
  2. doi Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver
    Ji Yin Zhou
    Base for Drug Clinical Trial, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, PR China
    Fitoterapia 82:184-9. 2011
    ..These results suggest that the effects of berberine on up-regulation of P-TEFb expression, antioxidant and antilipid peroxidation may be related to its protective potential on diabetes...
  3. doi Updating the RNA polymerase CTD code: adding gene-specific layers
    Sylvain Egloff
    Universite de Toulouse, UPS, Laboratoire de Biologie Moleculaire Eucaryote, F 31000 Toulouse, France
    Trends Genet 28:333-41. 2012
    ..As modification of the CTD has a major impact on gene expression, a better understanding of the CTD code is integral to the understanding of how gene expression is regulated...
  4. pmc Control of transcriptional elongation
    Hojoong Kwak
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 2703 email
    Annu Rev Genet 47:483-508. 2013
    ..We then discuss Pol II elongation through the bodies of genes and the roles of FACT and SPT6, factors that allow Pol II to move through nucleosomes...
  5. ncbi Activation of MyoD-dependent transcription by cdk9/cyclin T2
    Cristiano Simone
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, Pennsylvania, PA 19122, USA
    Oncogene 21:4137-48. 2002
    ..Unlike the other cdks, cdk9 is not serum- or cell cycle-regulated and is instead involved in the regulation of transcriptional elongation by ..
  6. ncbi P-TEFb is a crucial co-factor for Myc transactivation
    Barbara Gargano
    Department of Structural and Functional Biology, University of Naples Federico II, Naples, Italy
    Cell Cycle 6:2031-7. 2007
    ..These results indicate that P-TEFb is recruited in vivo to Myc-target promoters and CDK9 activity is an important step for Myc-dependent stimulation of responsive genes.
  7. pmc Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes
    Yoichi Sunagawa
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization, 1 1 Mukaihata cho, Fukakusa, Fushimi ku, Kyoto, Japan
    J Biol Chem 285:9556-68. 2010
    ..By tandem affinity purification and mass spectrometric analyses, we identified cyclin-dependent kinase-9 (Cdk9) as a novel GATA4-binding partner. Cdk9 also formed a complex with p300 as well as GATA4 and cyclin T1...