Cd40lg

Summary

Gene Symbol: Cd40lg
Description: CD40 ligand
Alias: Cd40l, Tnfsf5, CD40 ligand, CD40 ligand CD154, CD40-L, tumor necrosis factor ligand superfamily member 5
Species: rat

Top Publications

  1. pmc CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells
    Yolanda C Nesbeth
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 184:5654-62. 2010
  2. pmc Acquisition of host-derived CD40L by HIV-1 in vivo and its functional consequences in the B-cell compartment
    Michael Imbeault
    Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Québec CHUL, 2705 Boul Laurier, Quebec, Canada
    J Virol 85:2189-200. 2011
  3. ncbi Enhanced P-selectin expression and increased soluble CD40 Ligand in patients with Type 1 diabetes mellitus and microangiopathy: evidence for platelet hyperactivity and chronic inflammation
    M Yngen
    Department of Medicine, Clinical Pharmacology Unit, Karolinska Hospital, 171 76, Stockholm, Sweden
    Diabetologia 47:537-40. 2004
  4. ncbi Association of soluble CD40 ligand with carotid atherosclerosis in Japanese type 1 diabetic patients
    N Katakami
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetologia 49:1670-6. 2006
  5. pmc The levels of soluble CD40 ligand and C-reactive protein in normal weight, overweight and obese people
    Ilkay Tugba Unek
    Dokuz Eylul University School of Medicine, Department of Internal Medicine, 35340, Inciralti, Izmir, Turkey
    Clin Med Res 8:89-95. 2010
  6. ncbi Expression of CD40 ligand on CD4+ T-cells and platelets correlated to the coronary artery lesion and disease progress in Kawasaki disease
    Chih Lu Wang
    Division of Allergy and Immunology, Chang Gung Children s Hospital at Kaohsiung, Chang Gung University, Niau Sung, Kaohsiung, Taiwan
    Pediatrics 111:E140-7. 2003
  7. ncbi Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, CA 95817, USA
    Diabetes 55:774-9. 2006
  8. ncbi Heme oxygenase-1 improves the survival of discordant cardiac xenograft through its anti-inflammatory and anti-apoptotic effects
    Xia Zhen-Wei
    Department of Pediatrics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Pediatr Transplant 11:850-9. 2007
  9. ncbi Antibody to gp39, the ligand for CD40 significantly inhibits the humoral response from Graves' thyroid tissues xenografted into severe combined immunodeficient (SCID) mice
    E Resetkova
    Endocrinology Research Laboratory, Wellesley Hospital, University of Toronto, Ontario, Canada
    Thyroid 6:267-73. 1996
  10. ncbi alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity
    S L Peng
    Section of Rheumatology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 158:2464-70. 1997

Scientific Experts

Detail Information

Publications102 found, 100 shown here

  1. pmc CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells
    Yolanda C Nesbeth
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 184:5654-62. 2010
    ..of CCL5, which recruits endogenous CCR5(+) dendritic cells to tumor locations and activate them through CD40-CD40L interactions...
  2. pmc Acquisition of host-derived CD40L by HIV-1 in vivo and its functional consequences in the B-cell compartment
    Michael Imbeault
    Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Québec CHUL, 2705 Boul Laurier, Quebec, Canada
    J Virol 85:2189-200. 2011
    ..It has been demonstrated previously that HIV-1 particles acquire the costimulatory molecule CD40L when budding from activated CD4(+) T cells...
  3. ncbi Enhanced P-selectin expression and increased soluble CD40 Ligand in patients with Type 1 diabetes mellitus and microangiopathy: evidence for platelet hyperactivity and chronic inflammation
    M Yngen
    Department of Medicine, Clinical Pharmacology Unit, Karolinska Hospital, 171 76, Stockholm, Sweden
    Diabetologia 47:537-40. 2004
    ..We therefore investigated patients with Type 1 diabetes mellitus, without ( n=19) and with ( n=20) microangiopathy, matched for glycaemic control and duration of disease, and matched with healthy control subjects ( n=27)...
  4. ncbi Association of soluble CD40 ligand with carotid atherosclerosis in Japanese type 1 diabetic patients
    N Katakami
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetologia 49:1670-6. 2006
    It has recently been shown that the soluble form of CD40 ligand (sCD40L) interacts with CD40 on vascular cells, leading to a variety of proinflammatory responses, and that serum sCD40L levels can be a predictive marker of cardiovascular ..
  5. pmc The levels of soluble CD40 ligand and C-reactive protein in normal weight, overweight and obese people
    Ilkay Tugba Unek
    Dokuz Eylul University School of Medicine, Department of Internal Medicine, 35340, Inciralti, Izmir, Turkey
    Clin Med Res 8:89-95. 2010
    ..Increasing evidence shows that engagement of soluble CD40 ligand (sCD40L) with its receptor plays a crucial role in the pathogenesis of atherosclerosis...
  6. ncbi Expression of CD40 ligand on CD4+ T-cells and platelets correlated to the coronary artery lesion and disease progress in Kawasaki disease
    Chih Lu Wang
    Division of Allergy and Immunology, Chang Gung Children s Hospital at Kaohsiung, Chang Gung University, Niau Sung, Kaohsiung, Taiwan
    Pediatrics 111:E140-7. 2003
    Kawasaki disease (KD) is an acute febrile vasculitic syndrome in children. CD40 ligand (CD40L) has been implicated in certain types of vasculitis. We proposed that CD40L expression might be correlated with coronary artery lesions in KD.
  7. ncbi Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, CA 95817, USA
    Diabetes 55:774-9. 2006
    ..CRP], plasma-soluble cell adhesion molecules [CAMs], monocyte chemoattractant protein 1, nitrotyrosine, CD40 ligand [CD40L], and monocyte function)...
  8. ncbi Heme oxygenase-1 improves the survival of discordant cardiac xenograft through its anti-inflammatory and anti-apoptotic effects
    Xia Zhen-Wei
    Department of Pediatrics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Pediatr Transplant 11:850-9. 2007
    ..Finally, HO-1 mitigated CD40L transcription in the xenograft and recipient spleen...
  9. ncbi Antibody to gp39, the ligand for CD40 significantly inhibits the humoral response from Graves' thyroid tissues xenografted into severe combined immunodeficient (SCID) mice
    E Resetkova
    Endocrinology Research Laboratory, Wellesley Hospital, University of Toronto, Ontario, Canada
    Thyroid 6:267-73. 1996
    ..e., collagen-induced rheumatoid arthritis). The binding between CD40 expressed on mature B cells and CD40 ligand (CD40L, gp39) transiently expressed on activated T helper cells (Th) further stabilizes the interactions (..
  10. ncbi alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity
    S L Peng
    Section of Rheumatology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 158:2464-70. 1997
    ..T cells and gamma delta T cells regulate systemic autoimmunity, lupus-prone mice were rendered deficient in CD40 ligand and/or alpha beta T cells by intercrossing CD40L -/- and TCR-alpha -/- knockouts, generating CD40L-intact or -..
  11. ncbi CD40 ligand induces an antileukemia immune response in vivo
    D Dilloo
    Division of Bone Marrow Transplantation and Cell and Gene Therapy Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 90:1927-33. 1997
    ..b>CD40 ligand (CD40L) is a costimulator molecule that directly activates T cells and may promote antigen presentation by CD40-..
  12. pmc Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice
    X F Lei
    Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Clin Invest 101:1342-53. 1998
    The objective of this study was to investigate the contribution of the interaction between CD40 and its ligand (CD40L) to antigen-induced airways inflammatory responses...
  13. ncbi Expression of CD40/CD40 ligand and Bcl-2 family proteins in labial salivary glands of patients with Sjögren's syndrome
    H Nakamura
    First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki City, Japan
    Lab Invest 79:261-9. 1999
    ..We determined the role of interactions between CD40 and CD40 ligand (CD40L) in these infiltrating lymphocytes on B-cell differentiation and expression of Bcl-2 family proteins...
  14. pmc Role of CD40-CVD40L in mouse severe malaria
    P F Piguet
    Department of Pathology, University of Geneva, 1 Rue M Servet, CMU, 1211 Geneva, Switzerland
    Am J Pathol 159:733-42. 2001
    We explored the role of CD40-CD40L (CD154) in the severe malaria elicited by Plasmodium berghei anka infection in mice...
  15. pmc Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity
    A Mehling
    Ludwig Boltzmann Institute for Cell Biology, Department of Dermatology and Immunology of the Skin, University of Munster, D 49149 Münster, Germany
    J Exp Med 194:615-28. 2001
    CD40-CD40 ligand (L) interactions play a pivotal role in immune-mediated inflammatory responses via the activation of antigen-presenting cells (APCs)...
  16. ncbi Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury
    Noel Y Calingasan
    Neuroscience Research, Maryland Research Laboratories, Otsuka Maryland Research Institute, Rockville, MD 20850, USA
    Neurobiol Aging 23:31-9. 2002
    ..The immune and inflammatory mediator CD40 ligand (CD40L) can augment the activation of cultured microglia by amyloid beta-protein (Abeta) and promote neuron ..
  17. ncbi Prevention of autoimmune diabetes in the DRBB rat by CD40/154 blockade
    Wayne V Moore
    Pediatric Endocrinology, Children s Mercy Hospital, 2401 Gilham Road, Kansas City, MO 64108, USA
    J Autoimmun 19:139-45. 2002
    ..The results indicate that the CD40/154 blockade can prevent diabetes by modifying the expansion or effector phase of the autoimmune diabetes...
  18. ncbi CD40, CD154, Bax and Bcl-2 expression in Sjögren's syndrome salivary glands: a putative anti-apoptotic role during its effector phases
    M Ohlsson
    Broegelmann Research Laboratory, Department of Microbiology and Immunology, University of Bergen, Bergen, Norway
    Scand J Immunol 56:561-71. 2002
    ..In conclusion, our study further supports the hypothesis about apoptosis resistance among SS focal IMCs and suggests a putative protective role of CD40 ligation in SS SG epithelium...
  19. ncbi Differences of soluble CD40L in sera and plasma: implications on CD40L assay as a marker of thrombotic risk
    Eugene R Ahn
    Wallace H Coulter Platelet Laboratory, Division of Hematology Oncology, University of Miami School of Medicine, 1475 NW 12th Avenue, Miami, FL 33136, USA
    Thromb Res 114:143-8. 2004
    Soluble CD40L (sCD40L) ELISA has emerged as a promising predictor of poor outcomes in acute coronary syndrome. Yet many blood processing techniques have been used with little consideration of their effect on the results.
  20. ncbi Intratumoral administration of immature dendritic cells following the adenovirus vector encoding CD40 ligand elicits significant regression of established myeloma
    Yongqing Liu
    Research Unit, Saskatchewan Cancer Agency and Departments of Microbiology, Immunology and Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 0W0
    Cancer Gene Ther 12:122-32. 2005
    Our previous study showed that J558 myeloma cells engineered CD40L lost their tumorigenicity in syngeneic mice, and the inoculation of J558/CD40L tumor cells further led to the protective immunity against wild tumors...
  21. ncbi The expression of CD40-CD40L and activities of matrix metalloproteinases in atherosclerotic rats
    Min Wu
    Department of Cardiology, First Affiliated Hospital of the Medical College, Shantou University, Shantou 515041, Guangdong Province, People s Republic of China
    Mol Cell Biochem 282:141-6. 2006
    This study investigated the expression of CD40, CD40 ligand (CD40L) and matrix metalloproteinases (MMPs) in dietary-induced atherosclerosis in rats...
  22. ncbi Blockade by nifedipine of advanced glycation end product-induced CD40-CD40 ligand interaction in endothelial cells
    S Yamagishi
    Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Drugs Exp Clin Res 31:221-6. 2005
    ..There is a growing body of evidence that CD40-CD40 ligand (CD40L) interaction also plays an important role in atherogenesis...
  23. ncbi The CD40/CD40 ligand system is involved in the pathogenesis of pemphigus
    Marzia Caproni
    Department of Dermatological Sciences, University of Florence, Florence, Italy
    Clin Immunol 124:22-5. 2007
    The CD40/CD40 ligand (CD40L) system has never been investigated in autoimmune bullous diseases belonging to the pemphigus group in humans...
  24. ncbi Autoimmune thrombocytopenia: flow cytometric determination of platelet-associated CD154/CD40L and CD40 on peripheral blood T and B lymphocytes
    Mohamed H Meabed
    Department of Pediatrics, Faculty of Medicine, Bani Suef University, Bani Suef, Egypt
    Hematology 12:301-7. 2007
    The CD40-CD40L system has pleiotropic effects in a variety of cells and biological processes including the immune response. Within the immune system, these molecules represent a critical link between its humoral and cellular arms...
  25. doi Elevated circulating levels of soluble CD-40 ligand in haemodialysis patients with symptomatic coronary heart disease
    Paik Seong Lim
    Division of Renal Medicine, Tungs Taichung Metroharbour Hospital, Taichung, Taiwan
    Nephrology (Carlton) 13:677-83. 2008
    ..The aim of this study was to determine the relationship between plasma soluble CD40 ligand (sCD40L) and symptomatic coronary heart disease (CHD) in end-stage renal disease (ESRD) patients on maintenance ..
  26. doi Immune modulation and apoptosis induction: Two sides of antitumoural activity of a standardised herbal formulation of Withania somnifera
    Fayaz Malik
    Division of Pharmacology, Indian Institute of Integrative Medicine Council of Scientific and Industrial Research, Canal Road, Jammu 180001, India
    Eur J Cancer 45:1494-509. 2009
    ..parallel, it enhanced the proliferation of CD4(+)/CD8(+) and NK cells along with an increased expression of CD40/CD40L/CD80. In addition, WSF also enhanced T cell activation in camptothecin treated tumour-bearing mice...
  27. doi Norepinephrine induces systolic failure and inhibits antiapoptotic genes in a polymicrobial septic rat model
    Mani Chopra
    Department of Biomedical Sciences, Texas A and M Health Science Center Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, USA
    Life Sci 87:672-8. 2010
    ..We examined the effect of norepinephrine (NE) infusion on left ventricular function and apoptotic genes during progression of polymicrobial sepsis...
  28. doi Low CD40L levels and relative lymphopenia in narcoleptic patients
    Fernando Morgadinho Santos Coelho
    Psychobiology Department, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Hum Immunol 72:817-20. 2011
    ..Although recent and important advances have been done, no study has analyzed the role of the CD40L in patients with narcolepsy...
  29. doi β1-Adrenoceptor antibody-induced increase in soluble CD40 ligand release in chronic periodontitis patients: role of prostaglandin E(2)
    Leonor Sterin-Borda
    Pharmacology Unit, School of Dentistry, University of Buenos Aires, Argentina
    Exp Physiol 97:1030-9. 2012
    ..periodontitis patients reacting with atrial β(1)-adrenoceptors (β(1)-ARs) act as an inducer of soluble CD40 ligand (sCD40L) release and prostaglandin E(2) (PGE(2)) generation...
  30. pmc Effects of xinfeng capsules on expression of platelet granule membrane protein 140 and platelet cluster of differentiation 40 ligand in peripheral blood of adjuvant arthritis rats
    Zong Rui-Kai
    Hubei University of Traditional Chinese Medicine, Hubei, Wuhan 430065, China
    Int J Rheumatol 2012:139696. 2012
    Platelet GMP-140 and CD40L as specific markers of platelet activation play an important role in the morbidity and development of rheumatoid arthritis. The expression of GMP-140, CD40L increases in peripheral blood of AA rats...
  31. pmc Zinc finger protein A20 protects rats against chronic liver allograft dysfunction
    Jie Yang
    Department of Liver and Vascular Surgery, Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 18:3537-50. 2012
    ..To investigate the effect of zinc finger protein A20 on chronic liver allograft dysfunction in rats...
  32. doi Hypothermic oxygenated perfusion (HOPE) protects from biliary injury in a rodent model of DCD liver transplantation
    Andrea Schlegel
    Department of Surgery, Laboratory of the Swiss HPB and Liver Transplantation Center, University Hospital Zurich, Switzerland
    J Hepatol 59:984-91. 2013
    ..We analyze the impact of an end-ischemic Hypothermic Oxygenated PErfusion (HOPE) approach applied only through the portal vein for 1h before graft implantation...
  33. doi Effect of atorvastatin on atherosclerotic plaque formation and platelet activation in hypercholesterolemic rats
    Ayse Yesim Gocmen
    Department of Biochemistry, Faculty of Medicine, Bozok University, 66200 Yozgat, Turkey
    Can J Physiol Pharmacol 91:680-5. 2013
    We aimed to investigate whether atorvastatin influenced the CD40-CD40L pathway in atherosclerosis formation in rats fed a high cholesterol diet...
  34. doi A phase 1 study of prasugrel in patients with sickle cell disease: effects on biomarkers of platelet activation and coagulation
    Joseph A Jakubowski
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN USA Electronic address
    Thromb Res 133:190-5. 2014
    ..In this study, we assess the effect of prasugrel on biomarkers of platelet activation and coagulation in patients with SCD...
  35. pmc Repetitive hyperbaric oxygenation attenuates reactive astrogliosis and suppresses expression of inflammatory mediators in the rat model of brain injury
    Irena Lavrnja
    Department of Neurobiology, Institute for Biological Research Sinisa Stankovic, University of Belgrade, 11060 Belgrade, Serbia
    Mediators Inflamm 2015:498405. 2015
    ..In addition, HBOT prevents expression of CD40 and its ligand CD40L on microglia, neutrophils, cortical neurons, and reactive astrocytes...
  36. pmc Urocortin-1 Mediated Cardioprotection Involves XIAP and CD40-Ligand Recovery: Role of EPAC2 and ERK1/2
    Eva Calderón-Sanchez
    Grupo de Fisiopatología Cardiovascular, Instituto de Biomedicina de Sevilla IBiS, HUVR Universidad de Sevilla CSIC, Seville, Spain
    PLoS ONE 11:e0147375. 2016
    ..The aim of this study was to investigate the molecular signaling implicated in the improvement of cardiac myocytes survival induced by Ucn-1...
  37. doi Cilostazol exerts antiplatelet and anti-inflammatory effects through AMPK activation and NF-kB inhibition on hypercholesterolemic rats
    Nadia Alice Vieira da Motta
    Departamento de Fisiologia e Farmacologia, Laboratório de Farmacologia Experimental LAFE, Instituto Biomedico, Universidade Federal Fluminense UFF, Sala 204 A, 24230 210, Niteroi, Rio de Janeiro, Brazil
    Fundam Clin Pharmacol 30:327-37. 2016
    ..Expression of P-selectin, CD40L, PKC-α, IkB-α, and iNOS and activation of AMPK, NF-κB, and eNOS in the platelets were assessed using Western ..
  38. doi Evaluating antithrombotic activity of HY023016 on rat hypercoagulable model
    Qiu Fang Chen
    Department of Pharmacology, China Pharmaceutical University, Nanjing, Jiangsu, China
    Eur J Pharmacol 781:190-7. 2016
    ..HY023016 was able to inhibit thrombin- or ADP-induced platelet P-selectin or CD40L expression, leukocyte CD11b expression and formation of platelet-leukocyte aggregates in dose-dependent manner...
  39. doi The ginsenoside metabolite compound K exerts its anti-inflammatory activity by downregulating memory B cell in adjuvant-induced arthritis
    Jingyu Chen
    a Institute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti inflammatory and Immune Medicine, Ministry of Education, Hefei, China
    Pharm Biol 54:1280-8. 2016
    ..Our previous study demonstrated that CK exerted its anti-inflammatory effect via inhibition of abnormal activation and differentiation of T cells. However, its mechanism of action on B cells remains unclear...
  40. ncbi Inhibition of the CD40-CD40ligand pathway prevents murine membranous glomerulonephritis
    L Biancone
    Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    Kidney Int 48:458-68. 1995
    ..production requires T cell costimulatory signals provided in part by T cell surface expression of gp39/CD40ligand (CD40L) that engages the B cell receptor CD40 and induces B cell differentiation and immunoglobulin class switching...
  41. ncbi Heightened CD40 ligand gene expression in peripheral CD4+ T cells from patients with kidney allograft rejection
    A Shoker
    Department of Medicine, Royal University Hospital, Saskatoon, Saskatchewan, Canada
    Transplantation 70:497-505. 2000
    b>CD40 ligand (CD40L) gene expression is increased in rejecting allograft biopsies. We, therefore, tested the possibility that CD40L gene expression is heightened in peripheral CD4+ T cells during renal allograft rejection.
  42. ncbi Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease
    Tetsuya Higuchi
    Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    J Immunol 168:9-12. 2002
    b>CD40 ligand (CD40L) is ectopically expressed on B cells in patients with systemic lupus erythematosus (SLE) and lupus-prone BXSB mice...
  43. ncbi A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
    Dimitrios T Boumpas
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Arthritis Rheum 48:719-27. 2003
    CD40-CD40 ligand (CD40L) interactions play a significant role in the production of autoantibodies and tissue injury in lupus nephritis...
  44. ncbi Blockade of CD40-CD40 ligand protects against renal injury in chronic proteinuric renal disease
    Lukas Kairaitis
    Department of Renal Medicine, The University of Sydney at Westmead Hospital, Westmead, Sydney, Australia
    Kidney Int 64:1265-72. 2003
    Interaction between CD40 and CD40 ligand (CD40L) is involved in both cognate and innate immune responses. Blockade of CD40-CD40L interactions reduces severity of renal injury in murine lupus nephritis and membranous nephropathy...
  45. ncbi Distinct mechanisms of action of anti-CD154 in early versus late treatment of murine lupus nephritis
    Sergio A Quezada
    Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Arthritis Rheum 48:2541-54. 2003
    ..The aims of this study were to identify the mechanism of this early effect, to determine whether late anti-CD154 treatment could halt established nephritis, and, if so, to examine potential mechanisms of late efficacy...
  46. ncbi Intrinsic renal cell expression of CD40 directs Th1 effectors inducing experimental crescentic glomerulonephritis
    Amanda Jane Ruth
    Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia
    J Am Soc Nephrol 14:2813-22. 2003
    ..Immune neutralization of the CD40 ligand (CD154) at the time of challenge significantly reduced accumulation of Th1 effectors and injury...
  47. ncbi CD40/154 blockade and rejection of islet allografts in the streptozotocin and autoimmune diabetic rat
    K L Kover
    Section of Pediatric Endocrinology, Children s Mercy Hospital and University of Kansas Missouri Kansas City, 64108, USA
    Pediatr Diabetes 2:178-83. 2001
    ..The results indicate the importance of testing regimen of islet transplantation in animal models of autoimmune diabetes...
  48. ncbi Increased soluble CD40 ligand levels in cystic fibrosis
    A Falco
    Center of Excellence on Aging, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    J Thromb Haemost 2:557-60. 2004
    ..we carried-out a cross-sectional study to evaluate circulating levels of the inflammatory mediators soluble (s) CD40L, C-reactive protein (CRP), interleukin (IL)-1beta, the coagulation markers activated factor VII (FVIIa) and ..
  49. ncbi Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: an open-label trial
    P P Sfikakis
    Athens University Medical School, Athens, Greece
    Arthritis Rheum 52:501-13. 2005
    ..This open-label study was undertaken to evaluate the efficacy of the anti-CD20 monoclonal antibody rituximab in the treatment of lupus nephritis...
  50. ncbi CD40 ligand (CD154) takes part in regulation of the transition to mononuclear cell dominance during peritonitis
    Julia Mazar
    Department of Nephrology, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel
    Kidney Int 67:1340-9. 2005
    ..The aim of the present study was to investigate the role of CD40 ligation in leukocyte recruitment during peritonitis...
  51. ncbi AdCD40L gene therapy counteracts T regulatory cells and cures aggressive tumors in an orthotopic bladder cancer model
    Angelica S I Loskog
    Rudbeck Laboratory, Clinical Immunology Division, Uppsala University, Uppsala, Sweden
    Clin Cancer Res 11:8816-21. 2005
    ..an immunostimulating gene therapy for the treatment of orthotopic bladder carcinoma by transferring the gene for CD40L into the tumor site...
  52. ncbi CD40-CD154 expression in calcified and non-calcified coronary lesions of patients with chronic renal failure
    Valentina Campean
    Department of Pathology, University of Erlangen Nurnberg, Germany
    Atherosclerosis 190:156-66. 2007
    ..Activation of cells and adhesion molecules in atherosclerosis is governed by CD40-CD154 (CD40 ligand) interaction...
  53. ncbi Allogenic mixed chimerism induced by nonlymphoablative regimen including donor BMT with low-dose TBI and anti-CD40L cured proliferative glomerulonephritis in lupus mice
    Emiko Takeuchi
    Department of Clinical Investigation, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara City, Kanagawa 228 8555, Japan
    Ann N Y Acad Sci 1110:362-7. 2007
    Allogeneic mixed chimerism achieved by low-dose total body irradiation (TBI) and anti-CD40L monoclonal antibody (mAb) with donor bone marrow transplantation (BMT) and host T cell depletion overcomes both allo- and autoimmunity...
  54. ncbi Effect of statins on soluble CD40 ligand in hypercholesterolemic Type 2 diabetic patients
    E Santini
    Department of Internal Medicine, University of Pisa, I 56100 Pisa, Italy
    J Endocrinol Invest 31:660-5. 2008
    ..Soluble CD40 ligand (sCD40L), a marker of vascular inflammation, seems to predict vascular damage in patients with Type 2 diabetes...
  55. doi Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study
    Pradeep Tyagi
    Department of Urology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int Urol Nephrol 42:629-35. 2010
    ..To study the hypothesis of detecting bladder inflammation associated with overactive bladder (OAB) through altered urine levels of cytokines, chemokines, and growth factors...
  56. doi Soluble CD40 ligand is predictive of combined cardiovascular morbidity and mortality in patients on haemodialysis at a relatively short-term follow-up
    Giovambattista Desideri
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, Italy
    Nephrol Dial Transplant 26:2983-8. 2011
    We tested the hypothesis that soluble CD40 ligand (sCD40L), a biomarker of proatherogenic inflammation, may be predictive of cardiovascular (CV) events in a subgroup of patients from the RISCAVID study, an observational and prospective ..
  57. pmc Platelet activation in patients with atherosclerotic renal artery stenosis undergoing stent revascularization
    Steven Haller
    Department of Medicine, University of Toledo Medical Center, Toledo, OH 43614, USA
    Clin J Am Soc Nephrol 6:2185-91. 2011
    Soluble CD40 ligand (sCD40L) is a marker of platelet activation; whether platelet activation occurs in the setting of renal artery stenosis and stenting is unknown...
  58. doi Simultaneous blockade of the CD40/CD40L and NF-κB pathways prolonged islet allograft survival
    Xiao Hong Wang
    Department of Renal Transplant, Center of Nephropathy, The First Affiliated Hospital, Medical College, Xi an Jiaotong University, Xi an, Shanxi Province, China
    Transpl Int 25:118-26. 2012
    Activation of NF-κB pathway and co-stimulatory system CD40/CD40L promotes the inflammation, which plays a key role in the failure of islet graft...
  59. doi Combination of IL-1 receptor antagonist, IL-20 and CD40 ligand for the prediction of acute cellular renal allograft rejection
    Xiaoguang Xu
    Organ Transplantation Institute, 309th Hospital of the Chinese People s Liberation Army, 17th Heishanhu Road, Haidian District Beijing, 100091, China
    J Clin Immunol 33:280-7. 2013
    ..The outcome of renal transplantation is difficult to predict, even with an allograft biopsy. The aim of this study was to develop a sensitive, specific and noninvasive method for prediction of acute cellular rejection (ACR)...
  60. ncbi [Effects of electroacupuncture intervention on blood lipid levels and expression of CD 40 L and MMP-9 in the coronary artery tissue in coronary heart disease rats]
    Meng Li
    Anhui College of Chinese Medicine, Hefei, China
    Zhen Ci Yan Jiu 38:123-8. 2013
    ....
  61. doi The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis
    Vincent W S Lee
    Centre for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney at Westmead Hospital, NSW, Australia
    Nephrol Dial Transplant 25:717-30. 2010
    Blockade of CD40-CD40 ligand (CD154) interactions protects against renal injury in adriamycin nephropathy (AN) in immunocompetent mice...
  62. ncbi The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome
    A Aruffo
    Bristol Myers Squibb, Pharmaceutical Research Institute, Seattle, Washington 98121
    Cell 72:291-300. 1993
    ..The gene encoding gp39 was mapped to Xq26, the X chromosome region where the gene responsible for HIM had previously been mapped. These data suggest that a defect in gp39 is the basis of X-linked HIM...
  63. ncbi Nucleotide sequence of the rat CD40 ligand
    K M Hallett
    Transplant Research Laboratory St Luke s Medical Center, Milwaukee, Wisconsin 53215, USA
    DNA Seq 10:405-6. 2000
  64. ncbi Involvement of CD40-CD40L signaling in postischemic lung injury
    Timothy M Moore
    Department of Physiology, University of Alabama College of Medicine, Mobile, Alabama 36688 0002, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1255-62. 2002
    ..Immunoneutralization of either CD40 or CD40L, cell surface proteins important in lymphocyte-endothelial cell proinflammatory events, results in significantly ..
  65. ncbi Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expressing CD154 on the pancreatic beta-cells
    Claus Haase
    Hagedorn Research Institute, Niels Steensens Vej 6, DK 2820 Gentofte, Denmark
    Diabetes 53:2588-95. 2004
    ..To test the effect of activating islet-associated APCs in situ, we generated transgenic mice expressing CD154 (CD40 ligand) under control of the rat insulin promoter (RIP)...
  66. ncbi Blockade of the CD154-CD40 costimulatory pathway prevents the development of experimental autoimmune glomerulonephritis
    John Reynolds
    Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Kidney Int 66:1444-52. 2004
    ..Our hypothesis was that blocking the interaction between CD154 (CD40L) on Th cells and CD40 on antigen-presenting cells should inhibit T-cell activation, and thus the development of EAG...
  67. ncbi The efficacy of CD40 ligand blockade in discordant pig-to-rat islet xenotransplantation is correlated with an immunosuppressive effect of immunoglobulin
    Lars Wennberg
    Karolinska Institute, Department of Transplantation Surgery, Karolinska University Hospital, Huddinge, Sweden
    Transplantation 79:157-64. 2005
    The authors' aim was to evaluate the efficacy of immunosuppression with monoclonal anti-CD40 ligand antibodies (aCD40L) or nonspecific polyclonal intravenous immunoglobulin (IVIG) in the pig-to-rat islet xenotransplantation model.
  68. ncbi Soluble CD40 ligand in acute and chronic heart failure
    Thor Ueland
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Eur Heart J 26:1101-7. 2005
    Inflammatory cytokines may play a pathogenic role in heart failure (HF). CD40-CD40 ligand (CD40L) interactions are important in atherogenesis and based on its role in inflammation we sought to evaluate the role of CD40L in human HF.
  69. ncbi Platelet degranulation is associated with progression of intima-media thickness of the common carotid artery in patients with diabetes mellitus type 2
    Suzanne Fateh-Moghadam
    Medizinische Klinik III, Universitatsklinikum Tubingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    Arterioscler Thromb Vasc Biol 25:1299-303. 2005
    ..Platelets play a key role in atherogenesis and thromboembolic complications in patients with type 2 diabetes...
  70. ncbi Soluble P-selectin and CD40L levels in subjects with prediabetes, diabetes mellitus, and metabolic syndrome--the Chennai Urban Rural Epidemiology Study
    Kuppan Gokulakrishnan
    Dr Mohans M V Diabetes Specialities Centre and Madras Diabetes Research Foundation, Gopalapuram, Chennai 600 086, India
    Metabolism 55:237-42. 2006
    The aim of the study was to determine whether the levels of soluble P-selectin (sP-selectin) and soluble CD40L (sCD40L) are elevated in Asian Indian subjects with impaired glucose tolerance (IGT), diabetes, and metabolic syndrome (MS)...
  71. ncbi Costimulation and autoimmune diabetes in BB rats
    B C Beaudette-Zlatanova
    Department of Medicine, The University of Massachusetts Medical School, Worcester, and Transplantation Research Center, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Transplant 6:894-902. 2006
    ....
  72. ncbi Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy
    Daniela Veber
    Institute of General Pathology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Mangiagalli 31, 20133 Milano, Italy
    J Neuroimmunol 176:24-33. 2006
    ..In keeping with this, an anti-CD40 treatment prevented myelin lesions...
  73. ncbi B cells play a cooperative role via CD40L-CD40 interaction in T cell-mediated experimental autoimmune neuritis in Lewis rats
    Wei Zhu
    Department of Otorhinolaryngology, First Hospital, Jilin University, Changchun, China
    Neurobiol Dis 25:642-8. 2007
    The expression of co-stimulatory molecules CD40 and CD40L was examined over the course of experimental autoimmune neuritis (EAN) induced in Lewis rats by immunization with bovine peripheral nerve myelin...
  74. ncbi Interaction between cytokines and sCD40L in patients with stable and unstable coronary syndromes
    D Tousoulis
    Athens University Medical School, Athens, Greece
    Eur J Clin Invest 37:623-8. 2007
    ..Although sCD40L is part of immune response, the mechanisms regulating its release in different disease states remain unknown...
  75. ncbi Molecular and functional analysis of a novel recombinant clone of rat (Rattus norvegicus) CD40 ligand (CD40L) gene
    Gunes Esendagli
    Department of Basic Oncology, Hacettepe University, Sihhiye, Ankara, 06100, Turkey
    Mol Biol Rep 36:83-9. 2009
    ..In this study, coding sequence of rat CD40 ligand (CD40L, CD154) was obtained from activated splenocytes, amplified, and cloned into a eukaryotic expression ..
  76. doi CD40L stimulation of rat dendritic cells specifically favors the IL-12/IL-10 ratio resulting in a strong T cell stimulatory capacity
    Annelein M Stax
    Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands
    Mol Immunol 45:2641-50. 2008
    ..To investigate the effect of CD40 triggering on rat DC, we cloned the rat CD40L gene and generated murine fibroblasts with stable expression (L-rCD40L)...
  77. doi Generation and characterization of a novel anti-rat CD40L antibody with inhibitory activities in vitro and in vivo
    Annelein M Stax
    Department Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol Methods 335:46-52. 2008
    The CD40-CD40L interaction plays a critical role in cell-mediated immune responses. Blocking this interaction has been shown to be beneficial in the treatment of various diseases studied in murine models...
  78. doi Increased concentrations of soluble CD40 ligand may help to identify type 1 diabetic adolescents and young adults at risk for developing persistent microalbuminuria
    F Chiarelli
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Diabetes Metab Res Rev 24:570-6. 2008
    ..Soluble CD40 ligand (sCD40L) is supposed to be one of the most likely candidates for both retinopathy and nephropathy.
  79. doi Adenovirus-mediated CD40L gene therapy induced both humoral and cellular immunity against rat model of hepatocellular carcinoma
    Tomonori Iida
    Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
    Cancer Sci 99:2097-103. 2008
    ..CD40L (AxCAmCD40L)-mediated gene therapy was studied for treatment of hepatocellular carcinoma (HCC) using CD40 ligand (CD40L) complementary DNA in rats...
  80. ncbi Immunogene therapy by adenovirus vector expressing CD40 ligand for metastatic liver cancer in rats
    Ken Hanyu
    Department of Surgery, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Anticancer Res 28:2785-9. 2008
    We have explored a gene-therapeutic approach to stimulate antitumor immunity by adenoviral-mediated transfer of CD40 ligand (CD40L) to treat metastatic liver cancer in a rat model.
  81. ncbi Primary tumor cells obtained from MNU-induced mammary carcinomas show immune heterogeneity which can be modulated by low-efficiency transfection of CD40L gene
    Gunes Esendagli
    Department of Basic Oncology, Institute of Oncology, Hacettepe University, Ankara, Turkey
    Cancer Biol Ther 8:136-42. 2009
    ..Low-efficiency transfection of CD40 ligand (CD40L) gene enhanced the expression of proinflammatory cytokines in the tumor cells and strengthened ..
  82. doi Enhanced levels of soluble CD40 ligand and C-reactive protein in a total of 312 patients with metabolic syndrome
    Ilkay Tugba Unek
    Department of Internal Medicine, Dokuz Eylul University School of Medicine, 35340 Inciralti, Izmir, Turkiye
    Metabolism 59:305-13. 2010
    ..Increasing evidence indicates that CD40-CD40 ligand interactions constitute an important mediator for vascular inflammation...
  83. doi Modified serum profiles of inflammatory and vasoconstrictive factors in patients with emotional stress-induced acute coronary syndrome during World Cup Soccer 2006
    Ute Wilbert-Lampen
    Medizinische Klinik und Poliklinik I, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Am Coll Cardiol 55:637-42. 2010
    ..We sought to assess whether emotional stress-induced acute coronary syndrome (ACS) is mediated by increased inflammatory and vasoconstrictive mediators...
  84. doi From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis
    John M Lincecum
    ALS Therapy Development Institute, Cambridge, Massachusetts, USA
    Nat Genet 42:392-9. 2010
    ..A therapy using a monoclonal antibody to CD40L was developed that slows weight loss, delays paralysis and extends survival in an ALS mouse model...
  85. doi Immunogene therapy against colon cancer metastasis using an adenovirus vector expressing CD40 ligand
    Tomonori Iida
    Department of Surgery, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Surgery 148:925-35. 2010
    ..We studied CD40 ligand (CD40L)-mediated immunogene therapy for metastatic liver cancer in rats.
  86. doi Soluble CD40L (CD154) is increased in patients with shock
    M Chew
    Department of Intensive Care Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Inflamm Res 59:979-82. 2010
    Recent data suggest that soluble CD40L (sCD40L) plays an important role in murine sepsis...
  87. doi Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease
    Y Li
    Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Mol Oral Microbiol 25:275-92. 2010
    ..In B cells, interleukin-2 (IL-2), macrophage-inhibiting factor, IL-19, IL-21, tumor necrosis factor (TNF), CD40 ligand (CD40L), CD70, bone morphogenetic protein 2 (BMP2), BMP3, and BMP10 were upregulated early; while IL-7, Fas ..
  88. pmc Alloimmune activation enhances innate tissue inflammation/injury in a mouse model of liver ischemia/reperfusion injury
    X Shen
    Department of Surgery, David Geffen School of Medicine University of California, Los Angeles, CA, USA
    Am J Transplant 10:1729-37. 2010
    ..These results provide new evidence that alloreactive CD4 T cells are capable of enhancing innate tissue inflammation and organ injury via an Ag-nonspecific CD154-dependent but IFN-gamma independent mechanism...
  89. pmc Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis
    Dirk Lievens
    Department of Pathology, Maastricht Center for Atherosclerosis Research, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Blood 116:4317-27. 2010
    b>CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells, is also expressed and functional on platelets. We investigated the thrombotic and inflammatory contributions of platelet CD40L in atherosclerosis...
  90. pmc A striking local esophageal cytokine expression profile in eosinophilic esophagitis
    Carine Blanchard
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 127:208-17, 217.e1-7. 2011
    ..Eosinophilic esophagitis (EE) is an emerging worldwide disease that mimics gastroesophageal reflux disease...
  91. doi Ileal immune dysregulation in necrotizing enterocolitis: role of CD40/CD40L in the pathogenesis of disease
    Jiliu Xu
    Division of Pediatric Gastroenterology, USA
    J Pediatr Gastroenterol Nutr 52:140-6. 2011
    ..a CD40-modulated cytokine, has been described, but the role of the IL-10 receptor (IL-10Rβ), CD40, and its ligand CD40L in disease pathogenesis is unknown...
  92. pmc Soluble CD40 ligand and prolactin levels in migraine patients during interictal period
    Sibel Guldiken
    Department of Endocrinology, Trakya University Medical Faculty, Edirne, Turkey
    J Headache Pain 12:355-60. 2011
    ..the relationship between prolactin levels and subclinical atherosclerosis risk factors such as soluble CD40 ligand (sCD40L) and high-sensitivity CRP (hsCRP) in migraine patients during interictal period...
  93. pmc Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L
    Dae Yong Kim
    Department of Pharmacology, Sungkyunkwan University School of Medicine, Suwon, South Korea
    J Neuroinflammation 8:25. 2011
    ..We previously demonstrated the possibility that astrocytes and mast cells interact in vitro and in vivo. This study aimed to investigate the signaling pathways and the role for astrocytes in the interaction of astrocytes and mast cells...
  94. pmc Relationship between markers of platelet activation and inflammation with disease activity in Wegener's granulomatosis
    Gunnar Tomasson
    Boston University BU School of Medicine, and Massachusetts General Hospital, Boston, Massachusetts, USA
    J Rheumatol 38:1048-54. 2011
    ..Our objective was to determine whether measures of platelet activation or inflammation are associated with disease activity in Wegener's granulomatosis (WG)...
  95. doi Abrogation of pathogenic IgG autoantibody production in CD40L gene-deleted lupus-prone New Zealand Black mice
    Evelyn Pau
    Arthritis Centre of Excellence, Toronto Western Research Institute, Toronto, Ontario, Canada
    Clin Immunol 139:215-27. 2011
    New Zealand Black (NZB) mice spontaneously develop a lupus-like autoimmune disease. Since CD40-CD40L interactions are important for B cell class-switch recombination and germinal center formation, we sought to understand the impact of ..
  96. ncbi [Changes of soluble CD40 ligand in patients with hyperlipidemia of blood stasis syndrome and its clinical significance]
    Lu Jin
    Department of Cardiovascular Diseases, Yueyang Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai
    Zhongguo Zhong Xi Yi Jie He Za Zhi 31:315-8. 2011
    To observe changes of soluble CD40 ligand (sCD40L) in patients with hyperlipidemia of blood stasis syndrome and its correlation with blood stasis syndrome integral, P-selectin, and high sensitive creatine reactive protein (hs-CRP), to ..
  97. doi Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG
    Stéphanie Rigaud
    Laboratoire du Développement Normal et Pathologique du Système Immunitaire, INSERM, Unité 768, Hopital Necker Enfants Malades, Paris, France
    Blood 118:252-61. 2011
    ..a hypomorphic hemizygous mutation in XIAP (XIAP(G466X)) that cosegregated with a rare polymorphism in CD40LG (CD40 ligand(G219R))...
  98. doi CD40L deficiency ameliorates adipose tissue inflammation and metabolic manifestations of obesity in mice
    Marjorie Poggi
    Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Arterioscler Thromb Vasc Biol 31:2251-60. 2011
    ..The CD40-CD40L costimulatory dyad plays a pivotal role in immune responses and in diseases such as atherosclerosis and may ..
  99. pmc Partial immune reconstitution of X-linked hyper IgM syndrome with recombinant CD40 ligand
    Ashish Jain
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 118:3811-7. 2011
    X-linked hyper IgM syndrome (XHM) is a combined immune deficiency disorder caused by genetic alterations in CD40 ligand. The purpose of this study was to investigate the safety and efficacy of recombinant CD40 ligand (rCD40L) in the ..

Research Grants2

  1. HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPY
    Henry Murray; Fiscal Year: 2005
    ..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
  2. Host Immunoregulation of Response to Antileishmanial Chemotherapy
    Henry Murray; Fiscal Year: 2007
    ..abstract_text> ..